Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Direct RNA Sequencing of Astronaut Blood Reveals Spaceflight-Associated m6A Increases and Hematopoietic Transcriptional Responses

[Nature Communications] Scientists reported key genetic pathways, including changes in erythrocyte regulation, stress induction, and immune changes affected by spaceflight.

An Autoinhibitory Switch of the LSD1 Disordered Region Controls Enhancer Silencing

[Molecular Cell] The authors demonstrated how the intrinsically disordered region of the corepressor LSD1 excluded transcription factor association, acting as a dynamic conformational switch that tuned repression of active cis-regulatory elements.

Longitudinal Magnetic Resonance Imaging Tracking of Transplanted Neural Progenitor Cells in the Spinal Cord Utilizing the Bright-Ferritin Mechanism

[Stem Cells Translational Medicine] Investigators applied a novel bright-ferritin magnetic resonance imaging mechanism to track human neural progenitor cells (hNPC) transplants longitudinally and on demand in the rat spinal cord. They genetically modified hNPCs to stably overexpress human ferritin.

Efficient Site-Specific Integration of Large Genes in Mammalian Cells via Continuously Evolved Recombinases and Prime Editing

[Nature Biomedical Engineering] The authors showed that phage-assisted continuous evolution enhances prime-editing-assisted site-specific integrase gene editing, which coupled the programmability of prime editing with the ability of recombinases to precisely integrate large DNA cargoes exceeding 10 kilobases.

Stepwise Dual-Release Microparticles of BMP-4 and SCF in Induced Pluripotent Stem Cell Spheroids Enhance Differentiation into Hematopoietic Stem Cells

[Journal of Controlled Release] Scientists developed two gelatin microparticles with different release patterns and two HSC-related growth factors conjugated to them.

The Expression of Galectin-9 Correlates with mTOR and AMPK in Murine Colony-Forming Erythroid Progenitors

[European Journal of Haematology] The bone marrow cells in adult C57BL/6J mice were collected and analyzed in vitro.

In Vivo Ablation of NF-κB Cascade Effectors Alleviates Disease Burden in Myeloproliferative Neoplasms

[Blood] Investigators systematically ablated NF-κB signaling effectors to identify core dependencies using a series of primary samples and syngeneic and patient–derived xenograft mouse models.

ctDNA Improves Prognostic Prediction for Patients with Relapsed/Refractory MM Receiving Ixazomib, Lenalidomide, and Dexamethasone

[Blood] The authors performed targeted-capture sequencing using bone marrow plasma cells and ctDNA of 261 RRMM cases uniformly treated with ixazomib, lenalidomide, and dexamethasone in a multicenter, prospective, observational study.

The Tumor Suppressor Fat1 Is Dispensable for Normal Murine Hematopoiesis

[Journal of Leukocyte Biology] Investigators used the Vav-iCre strain to construct conditional knockout mice where Fat1 expression was deleted at the HSC stage.

Iron Overload: The Achilles Heel of β-Thalassemia

[Transfusion Clinique et Biologique] Scientists discuss clinical management, current treatments, and future directions for thalassemia, focusing on iron overload and its complications.

Shattuck Labs Announces Orphan Drug Designation Granted by the US Food and Drug Administration (FDA) for SL-172154 for the Treatment of Acute Myeloid Leukemia...

[Shattuck Labs] Shattuck Labs, Inc. announced that the US FDA has granted orphan drug designation to lead clinical candidate SL-172154 for the treatment of AML.

Cellular and Humoral Immunogenicity against SARS-CoV-2 Vaccination or Infection Is Associated with the Memory Phenotype of T- and B-lymphocytes in Adult Allogeneic Hematopoietic Cell...

[International Journal of Hematology] Scientists conducted a cross-sectional study to evaluate cellular and humoral immunogenicity against SARS-CoV-2 vaccination or infection and examined how lymphocyte subpopulations in peripheral blood correlate with cellular and humoral immunogenicity in adult allogeneic hematopoietic cell transplantation recipients.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.