HSC-derived Mixed Lineage Leukemia- acute myeloid leukemia gene fusions was highly resistant to chemotherapy and expressed elevated amounts of the multispecific anion transporter ABCC3.
[Science Translational Medicine]
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Zeisig, B. B., Fung, T. K., Zarowiecki, M., Tsai, C. T., Luo, H., Stanojevic, B., Lynn, C., Leung, A. Y. H., Zuna, J., Zaliova, M., Bornhauser, M., Bonin, M. von, Lenhard, B., Huang, S., Mufti, G. J., & So, C. W. E. (2021). Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia. Science Translational Medicine, 13(582). https://doi.org/10.1126/scitranslmed.abc4822 Cite
From a consecutive cohort of 67 patients with nucleophosmin 1‐mutated (NPM1mut) acute myeloid leukemia , investigators identified 50 who achieved NPM1mut clearance and had parallel multicolour flow cytometry and next generation sequencing.
[British Journal of Haematology]
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Loghavi, S., DiNardo, C. D., Furudate, K., Takahashi, K., Tanaka, T., Short, N. J., Kadia, T., Konopleva, M., Kanagal‐Shamanna, R., Farnoud, N. R., Pierce, S., Khoury, J. D., Jorgensen, J. L., Patel, K. P., Daver, N., Yilmaz, M., Medeiros, L. J., Kantarjian, H., Ravandi, F., & Wang, S. A. (n.d.). Flow cytometric immunophenotypic alterations of persistent clonal haematopoiesis in remission bone marrows of patients with NPM1-mutated acute myeloid leukaemia. British Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjh.17347 Cite
Researchers demonstrated that CD20 controlled the nanoscale organization of receptors on the surface of resting B lymphocytes.
[Proceedings of the National Academy of Sciences of the United States of America]
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Kläsener, K., Jellusova, J., Andrieux, G., Salzer, U., Böhler, C., Steiner, S. N., Albinus, J. B., Cavallari, M., Süß, B., Voll, R. E., Boerries, M., Wollscheid, B., & Reth, M. (2021). CD20 as a gatekeeper of the resting state of human B cells. Proceedings of the National Academy of Sciences, 118(7). https://doi.org/10.1073/pnas.2021342118 Cite
Scientists summarize recent studies investigating the involvement of TAMs in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies.
[Signal Transduction and Targeted Therapy]
Single-cell gene expression profiling with parallel mutation detection demonstrated that the megakaryocyte-primed hematopoietic stem cells subpopulation expanded significantly with enhanced potential in untreated individuals with JAK2V617F+essential thrombocythemia, driven primarily by the JAK2 mutation and elevated interferon signaling.
[Cell Stem Cell]
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Tong, J., Sun, T., Ma, S., Zhao, Y., Ju, M., Gao, Y., Zhu, P., Tan, P., Fu, R., Zhang, A., Wang, D., Wang, D., Xiao, Z., Zhou, J., Yang, R., Loughran, S. J., Li, J., Green, A. R., Bresnick, E. H., … Shi, L. (2021). Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.01.018 Cite
Scientists demonstrated that lysosomal equilibrative nucleoside transporter 3 (ENT3) transport of taurine-conjugated bile acids (TBA) facilitated TBA chemical chaperone function and alleviated endoplasmic reticulum stress in expanding mouse hematopoietic stem and progenitor cells.
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Persaud, A. K., Nair, S., Rahman, M. F., Raj, R., Weadick, B., Nayak, D., McElroy, C., Shanmugam, M., Knoblaugh, S., Cheng, X., & Govindarajan, R. (2021). Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors. Nature Communications, 12(1), 1248. https://doi.org/10.1038/s41467-021-21451-6 Cite
International collaborative clinical trials have led to better understanding of the underlying molecular biology, refined risk-based stratification, and investigated the use of hematopoietic stem cell transplantation.
[Current Oncology Reports]
The authors discuss their approach to relapsed or refractory diffuse large B cell lymphoma patients and the open question of optimal sequencing of autologous transplant , CAR-T therapy, and bispecific antibodies.
[Current Hematologic Malignancy Reports]
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Doraiswamy, A., Shah, M. R., & Bannerji, R. (2021). Immunotherapies Old and New: Hematopoietic Stem Cell Transplant, Chimeric Antigen Receptor T Cells, and Bispecific Antibodies for the Treatment of Relapsed/Refractory Diffuse Large B Cell Lymphoma. Current Hematologic Malignancy Reports. https://doi.org/10.1007/s11899-021-00610-y Cite
Dr. Salvatore Papa, an Assistant Professor in Cancer Research at the University of Leeds, has been awarded Leukaemia & Myeloma Research UK’s research grant to continue his specialist studies into examining how the accumulation of mutated proteins in certain blood cancer cells allows them to multiply repeatedly.
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In November 2020, the FDA granted Regenerative Medicine Advanced Therapy designation for a cellular therapy called AB-205. AB-205 acts promptly to repair injured vascular niches of organs to prevent or reduce severe toxicities in patients who have Hodgkin lymphoma or non-Hodgkin lymphoma undergoing high dose chemotherapy and autologous stem cell transplantation.
[Hackensack University Medical Center (Newswise, Inc.)]
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Using unbiased global sequencing and directed genetic approaches focused on early mammalian development, the authors found that fetal liver macrophage exhibit a unique expression signature that differentiates them from erythroid and adult macrophage cells.