Scientists discover that hallmarks of aging in HSCs and hematopoiesis begin to accumulate by middle age and that the bone marrow microenvironment at middle age induced and was indispensable for hematopoietic aging.
[Cell Stem Cell]
Young, K., Eudy, E., Bell, R., Loberg, M. A., Stearns, T., Sharma, D., Velten, L., Haas, S., Filippi, M.-D., & Trowbridge, J. J. (2021). Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Cell Stem Cell. https://doi.org/10.1016/j.stem.2021.03.017 Cite
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