Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Ubiquitin Receptor PSMD4/Rpn10 Is a Novel Therapeutic Target in Multiple Myeloma

[Blood] Since proteasome inhibition is a common therapeutic strategy in multiple myeloma (MM), scientists investigated Rpn10, a subunit of the 19S proteasome unit, and found that it is highly expressed in MM cells versus normal plasma cells.

Aging Alters the Cell Cycle Control and Mitogenic Signaling Responses of Human Hematopoietic Stem Cells

[Blood] Investigators isolated highly HSC-enriched CD34+CD38-CD45RA-CD90+CD49f+ cells from cord blood and adult bone marrow and mobilized peripheral blood samples obtained from normal humans spanning seven decades of age.

Flt3- and Tie2-Cre Tracing Identifies Regeneration in Sepsis from Multipotent Progenitors but Not Hematopoietic Stem Cells

[Cell Stem Cell] Researchers analyzed by differentiation tracing, using inducible Tie2- or Flt3-driven Cre recombinase, the roles of mouse HSCs and multipotent progenitors.

Targeted Zinc-Finger Repressors to the Oncogenic HBZ Gene Inhibit Adult T-cell Leukemia (ATL) Proliferation

[NAR Cancer] A series of zinc-finger protein repressors were designed to target within the human T-lymphotropic virus type I (HTLV-I) promoter that drove HTLV-I bZIP factor (HBZ) expression at highly conserved sites covering a wide range of HTLV-I genotypes.

Persistent Hematopoietic Polyclonality after Lentivirus-Mediated Gene Therapy for Fabry Disease

[Molecular Therapy-Methods & Clinical Development] To evaluate the risks of clonal dominance and leukemogenesis, which have been reported in multiple gene therapy trials, investigators conducted a comprehensive DNA insertion site analysis of peripheral blood samples from the five patients in their gene therapy trial.

Characterization and Quantitation of Busulfan DNA Adducts in the Blood of Patients Receiving Busulfan Therapy

[Molecular Therapy-Oncolytics] Scientists used a DNA adductomic approach to characterize DNA adducts formed by reacting busulfan with calf-thymus DNA. Samples collected from 6 patients undergoing busulfan-based chemotherapy prior to allogeneic hematopoietic cell transplantation were analyzed for the presence of busulfan-derived DNA adducts.

Alterations of Cohesin Complex Genes in Acute Myeloid Leukemia: Differential Co-Mutations, Clinical Presentation, and Impact on Outcome

[Blood Cancer Journal] Researchers retrospectively analyzed data from a multi-center cohort of 1615 intensively treated AML patients and identified distinct co-mutational patters for mutations of cohesin subunit SA-2.

Characterization of Myeloproliferative Neoplasms in the Pediatric and Young Adult Population

[British Journal Of Haematology] Investigators compared the genomic features and clinical outcomes between pediatric and young adult patients, and older adults with myeloproliferative neoplasms to gain insight into pathogenesis, disease prognosis, and management.

Impact of Surface Coating and Systemic Anticoagulants on Hemostasis and Inflammation in a Human Whole Blood Model

[Plos One] Scientists investigated the impact of different protocols for surface coating of synthetic material and different anticoagulants on hemostasis and platelet activation in ex vivo human whole blood.

Therapy-Selected Clonal Hematopoiesis and Its Role in Myeloid Neoplasms

[Leukemia Research] The authors review the current knowledge of the genomic landscape of therapy-related myeloid neoplasms, discuss background knowledge of clonal hematopoiesis gained from studies of de novo myeloid neoplasms, and examine the recent literature studying the role of therapeutic selection of clonal hematopoiesis and its evolution under the effects of antineoplastic therapy.

Priothera Announces First Patients Enrolled in Pivotal MO-TRANS Global Phase IIb/III Study with Mocravimod as an Adjunctive and Maintenance Therapy for Patients with Acute...

[Priothera ( Cision US Inc.)] Priothera announced that the first patients have been enrolled in the pivotal MO-TRANS global Phase IIb/III study evaluating mocravimod in AML patients undergoing allogeneic hematopoietic cell transplant.

Distinct Clonal Identities of B-ALLs Arising after Lenolidomide Therapy for Multiple Myeloma

[Blood Advances] Samples from 17 patients with with multiple myeloma treated with lenalidomide, who subsequently developed B-cell acute lymphoblastic leukemia (B-ALL) were evaluated through sequencing, cytogenetics/fluorescence in situ hybridization, immunohistochemical staining, and immunoglobulin heavy chain clonality assessment.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.

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