Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
From a Drug Repositioning to a Structure-Based Drug Design Approach To Tackle Acute Lymphoblastic Leukemia
[Nature Communications] Scientists presented the development of a potent inhibitor of deoxycytidine kinase by applying an iterative multidisciplinary approach, which relied on computational design coupled with experimental evaluations.
Young Donor Hematopoietic Stem Cells Revitalize Aged or Damaged Bone Marrow Niche by Transdifferentiating Into Functional Niche Cells
[Aging Cell] Researchers showed that disabling HSCs based on disrupting autophagy accelerated niche aging in mice, whereas transplantation of young, but not aged or impaired, donor HSCs normalized niche cell populations and restored niche factors in host mice carrying an artificially harassed niche.
Deletion of CD36 Exhibits Limited Impact on Normal Hematopoiesis and the Leukemia Microenvironment
[Cellular & Molecular Biology Letters] Differential expression data of CD36 during human and mouse normal hematopoiesis were examined and compared. Cd36 knockout mice were evaluated for blood analysis, hematopoietic stem cells and progenitors function and phenotype analyses, and T cells in vitro expansion and phenotypes in comparison with wild type (WT) mice.
Mutation Spectrum of FLT3 and Significance of Non-Canonical FLT3 Mutations in Hematological Malignancy
[British Journal of Haematology] Investigators profiled the spectrum of Fms-like tyrosine kinase 3 (FLT3) mutations in 869 consecutively newly diagnosed AML, myelodysplastic syndrome, and acute lymphoblastic leukemia patients.
Single-Cell Gene and Isoform Expression Analysis Reveals Signatures of Aging in Hematopoietic Stem and Progenitor Cells
[Communications Biology] Researchers presented an integrated short- and long-read single-cell RNA-seq analysis of hematopoietic stem and progenitor cells. They demonstrated that over half of genes detected in standard short-read single-cell analyses were expressed as multiple, often functionally distinct, isoforms, including many transcription factors and key cytokine receptors.
Cell-Cell Interactome of the Hematopoietic Niche and Its Changes in Acute Myeloid Leukemia
[iScience] Scientists presented a high-resolution characterisation of the bone marrow (BM) niche in health and AML by establishing a single-cell gene expression database of 339,381 BM cells.
DHX9-Mediated Pathway Contributes to the Malignant Phenotype of Myelodysplastic Syndromes
[iScience] The authors analyzed the expression of DHX9 and its clinical significance in 120 Myelodysplastic syndrome (MDS) patients and 42 non-MDS controls. Lentivirus-mediated DHX9 knockdown experiments were performed to investigate its biological function.
Neurodegenerative Disease After Hematopoietic Stem Cell Transplantation in Metachromatic Leukodystrophy
[Annals Of Clinical And Translational Neurology] Three metachromatic leukodystrophy patients treated with hematopoietic stem cell transplantation with a progressive clinical course despite stable white matter pathology were clinically and radiologically analyzed.
GATA2 Deficiency: Predisposition to Myeloid Malignancy and Hematopoietic Cell Transplantation
[Current Hematologic Malignancy Reports] Scientists review the clinical manifestations of GATA2 deficiency, characterization of the hematologic abnormalities and progression to myeloid malignancy, and current hematopoietic cell transplantation practices and outcomes.
NIH Toughens Enforcement of Delayed Clinical Trials Reporting
[Science] The US National Institutes of Health (NIH) delivered a stern warning to two in-house clinical researchers who had broken an important rule. They had failed to submit the results of two clinical trials they had overseen to ClinicalTrials.gov, a database meant to inform the public about human studies and their results.
Metabolic Adaptation to Tyrosine Kinase Inhibition in Leukemia Stem Cells
[Blood] Researchers performed a comprehensive evaluation of metabolic adaptation to tyrosine kinase inhibitor treatment and its role in chronic myelogenous leukemia hematopoietic stem and progenitor cell persistence.
A Novel Stemness Classification in Acute Myeloid Leukemia by the Stemness Index and the Identification of Cancer Stem Cell-Related Biomarkers
[Frontiers In Immunology] The authors characterized stem cell-related gene expression and identified stemness biomarker genes in acute myeloid leukemia. They calculated the stemness index based on transcription data using the one-class logistic regression algorithm for patients in the training set.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.