Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation

[Cancer Discovery] Investigators describes a novel animal model carrying a recurrent TET2 missense mutation, frequently found in clonal hematopoiesis and leukemic patients.

Combining Nilotinib and PD-L1 Blockade Reverses CD4+ T Cell Dysfunction and Prevents Relapse in Acute B-cell Leukemia

[Blood] Single-cell RNA-sequence analysis revealed that B-ALL induces a unique subset of CD4+ T cells with both cytotoxic and helper functions.

Predictive Factors and Outcomes After Allogeneic Stem-Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil

[Transplantation and Cellular Therapy ] Investigators described outcomes and examine risk factors for overall survival, leukemia-free survival, cumulative incidence of relapse, non-relapse mortality and graft-versus-host disease after allogeneic stem-cell transplantation for acute lymphoblastic leukemia in Brazilian centers.

B Cell Antigen Receptor Expression and Phosphatidylinositol 3-Kinase Signaling Regulate Genesis and Maintenance of Mouse Chronic Lymphocytic Leukemia

[Haematologica] By ablating the B cell antigen receptor in chronic lymphocytic leukemia (CLL) cells from TCL1 transgenic mice, the authors showed that CLL cells cannot survive without BCR signaling and are lost within eight weeks in diseased mice.

Sorting Nexin 24 Is Required for α-Granule Biogenesis and Cargo Delivery in Megakaryocytes

[Haematologica] The authors investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be involved in platelet α-granule biogenesis by undertaking transcriptome analysis of control platelets and platelets harboring a DNA-binding variant of FLI1.

Platelet-Inspired Intravenous Nanomedicine for Injury-Targeted Direct Delivery of Thrombin to Augment Hemostasis in Coagulopathies

[ACS Nano] Scientists reported on the design and evaluation of thrombin-loaded injury-site-targeted lipid nanoparticles that could specifically localize at an injury site via platelet-mimetic anchorage to the von Willebrand factor and collagen.

Fate Mapping of Hematopoietic Stem Cells Reveals Two Pathways of Native Thrombopoiesis

[Nature Communications] Researchers chart native lineage pathways emanating from HSCs and define their physiological regulation by computationally integrating experimental approaches for fate mapping, mitotic tracking, and single-cell RNA sequencing.

Metabolic Regulation of Hematopoietic Stem Cells

[HemaSphere] The authors discuss recent insights into the regulatory roles of cellular metabolism in HSCs. Understanding the metabolic requirements of healthy HSCs is of critical importance to the development of new therapies for hematological disorders.

Gastruloids as In Vitro Models of Embryonic Blood Development with Spatial and Temporal Resolution

[Scientific Reports] Recently, scientists adapted gastruloid culture conditions to promote cardiovascular development. In this work, they extended these conditions to capture features of embryonic blood development through a combination of immunophenotyping, detailed transcriptomics analysis, and identification of blood stem/progenitor cell potency.

Synergistic Prostaglandin E Synthesis by Myeloid and Endothelial Cells Promotes Fetal Hematopoietic Stem Cell Expansion in Vertebrates

[EMBO Journal] Researchers showed that in the zebrafish embryo, prostaglandin E2 synthesis genes are expressed by distinct stromal cell populations, myeloid, and endothelial cells of the caudal hematopoietic tissue.

CRISPR–Cas9-Mediated Gene Editing of the BCL11A Enhancer for Pediatric β0/β0 Transfusion-Dependent β-Thalassemia

[Nature Medicine] The authors report the preliminary results of an ongoing phase I/II trial evaluating safety and efficacy of gene editing therapy in children with blood transfusion-dependent β-thalassemia.

Orca Bio Announces the Precision-T Phase III Study Is Open and Enrolling Patients at Transplant Centers across the US

[Orca Bio] Orca Bio announced Precision-T, its pivotal Phase III study, is open, enrolling and treating patients at clinical trial sites including Stanford Health Care, City of Hope, Winship Cancer Institute of Emory University, Sarah Cannon Research Institute, Ronald Reagan UCLA Medical Center and Oregon Health & Science University.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.