Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

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UBC Medicine Researchers Awarded More Than $39 Million in CIHR Funding

August 17, 2026

[The University of British Columbia] UBC Faculty of Medicine researchers have been awarded more than $39 million in federal funding through the Canadian Institutes of Health Research (CIHR) Project Grant: Spring 2026 competition.

$1 Million Grant Fuels Research on Precise Cancer Radiation

August 14, 2026

[University of Missouri School of Medicine] Researchers from the University of Missouri School of Medicine recently received a $1 million grant from the National Institutes of Health to study the latest technology in cancer research.

Human HSPCs Clones Balance Stochastic Diversification with Cytokine-Induced Differentiation

August 4, 2026

[Blood] Investigators introduced clonal Hematopoietic stem and progenitor cell tracker (cHSPCTrack), an in vitro framework for serially tracking clonal differentiation and fate acquisition from human HSPCs extracted from circulation.

MLL3 and MLL4 Sustain Hematopoietic Stem Cell Multipotency by Opposing a B Cell Default State

August 4, 2026

[Blood] In this study, researchers conditionally deleted Mll3, Mll4, or both genes together to determine how each gene controls divergent hematopoietic stem cell fate decisions.

A Selective CK1α Degrader Targets Acute Myeloid Leukemia and Spares Normal Hematopoietic Cells

August 4, 2026

[Cancer Research] Investigators developed and evaluated PinA1, a molecular glue degrader targeting casein kinase 1⍺ (CK1⍺), in preclinical AML models.

Targeting ACSF2 Overcomes Ara-C Resistance in Acute Myeloid Leukemia via the Cholesterol Metabolism-ERK Signaling Axis

August 4, 2026

[Leukemia] Researchers identified ACSF2 as a key metabolic determinant of cytarabine (Ara-C) resistance. ACSF2 inhibition suppresses Ara-C-resistant AML cell proliferation, restores Ara-C sensitivity in vitro and in vivo.

MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis

August 4, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Scientists defined a regulatory mechanism in which MORC2 modulates hypoxia-inducible factor (HIF)-1α stability via HDAC4 mediated deacetylation, shedding light on hematopoiesis and HIF-related disorders.

A Phase I/Ib Study of the All-Oral Regimen CC-486 and Venetoclax in Acute Myeloid Leukemia

August 4, 2026

[Blood Advances] In this single center open label, Phase 1/1b study, researchers investigated CC-486 and venetoclax in relapsed and refractory AML and newly diagnosed patients.

Extracellular Vesicles in Acute Myeloid Leukemia: Opportunities and Obstacles for Therapeutic Advancement

August 4, 2026

[Journal of Biochemical and Molecular Toxicology] The authors synthesize and discuss recent discoveries on the roles and therapeutic potential of extracellular vesicles in AML.

Mechanistic Insights Into Gene Regulation Driving Normal and Malignant Hematopoietic Development from Embryonic and Induced Pluripotent Stem Cell Differentiation

August 4, 2026

[Experimental Hematology] The following review highlights how embryonic and iPSC models are uncovering the gene regulatory mechanisms that drive normal and malignant blood cell development, advancing regenerative medicine and leukemia research.

Sumitomo Pharma America Announces Enzomenib (DSP-5336) Receives FDA Orphan Drug Designation for Treatment of Acute Lymphoblastic Leukemia

August 4, 2026

[Sumitomo Pharma America, Inc.] Sumitomo Pharma America, Inc. announced that the US FDA has granted orphan drug designation to enzomenib for the treatment of patients with acute lymphoblastic leukemia.

NWO Awards Ten Veni Grants to Promising UM Researchers

July 22, 2026

[Maastricht University] As many as ten young UM researchers have been awarded a Veni grant worth up to €320,000 from the Netherlands Organisation for Scientific Research (NWO).

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.