Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Subscribe|Follow Us On

HLA A*24:02–Restricted T Cell Receptors Cross-Recognize Bacterial and Preproinsulin Peptides in Type 1 Diabetes

September 18, 2024

[Journal of Clinical Investigation] Combinatorial peptide library screening was used to produce a preferred peptide recognition landscape for a patient-derived T cell receptor that recognized the preproinsulin-derived peptide sequence LWMRLLPLL in the context of disease risk allele HLA A*24:02.

Outcomes of Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Amegakaryocytic Thrombocytopenia; a Study on Behalf of the PDWP of the EBMT

September 18, 2024

[Bone Marrow Transplantation] In this retrospective study, scientists analyzed 66 patients with allo-hematopoietic stem cell transplantation, reported in the European Society for Blood and Marrow Transplantation registry. Bone marrow was the most widely used stem cell source followed by peripheral blood, and unrelated umbilical cord blood.

Therapeutic Efficacy of Intracerebral Hematopoietic Stem Cell Gene Therapy in an Alzheimer’s Disease Mouse Model

September 16, 2024

[Nature Communications] Researchers explored the transplantation efficacy of different cell subsets and delivery routes with the goal of favoring the establishment of a stable and exclusive engraftment of hematopoietic stem/progenitor cells and their progeny in the central nervous system of female mice.

Flow Cytometric Expression of Bcl-2, Mcl-1, and Their Ratios Correlates With Primary and Secondary Cytogenetic Changes and Their Combinations in Multiple Myeloma

September 16, 2024

[Annals of Hematology] The authors investigated the relationship between cytogenetic abnormalities and intracellular Bcl-2 and Mcl-1 expression in myeloma plasma cells using flow cytometry.

Transcripts of Repetitive DNA Elements Signal to Block Phagocytosis of Hematopoietic Stem Cells

September 16, 2024

[Science] To investigate the cues mediating grooming versus dooming, scientists screened a panel of 1200 bioactive small molecules in human cells and identified 93 compounds that robustly increased surface calreticulin in a dose-dependent manner.

Association of ADAM Family Members with Proliferation Signaling and Disease Progression in Multiple Myeloma

September 16, 2024

[Blood Cancer Journal] High ADAM8/9/15 expression was associated with high-risk cytogenetic abnormalities and extramedullary disease. Furthermore, ADAM8/15 expression increased with multiple myeloma progression and in relapsed/refractory multuple myeloma compared to untreated patient samples.

Belantamab Mafodotin, Pomalidomide, and Dexamethasone for Triple Class Exposed/Refractory Relapsed Multiple Myeloma: A Subgroup Analysis of the ALGONQUIN Trial

September 16, 2024

[Blood Cancer Journal] Researchers presented a post-hoc subgroup analysis of triple class exposed/refractory (TCE/R) patients treated on the ALGONQUIN study of belantamab mafodotin plus pomalidomide-dexamethasone for relapsed multiple myeloma. Of the 99 patients treated on the ALGONQUIN study, 69 were TCE and 56 were TCR and were included in this analysis.

Post-Thaw CD34+ Cell Recovery Likely Degraded Under Extreme Graft Platelet Concentrations

September 16, 2024

[Bone Marrow Transplantation] A significant negative correction between platelet concentration and postCD34 recovery was observed overall, but upon further analysis only confirmed in the subset with graft platelets 1500–2000 ×109/L.

Cardiac Events Occurring after Allogeneic Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide. Study Conducted on Behalf of the GETH-TC

September 16, 2024

[Bone Marrow Transplantation] This multicenter study investigates the incidence and predictors of cardiac events following allo-HCT with PTCY in 453 AML patients.

Epigenetic Regulation of Hematopoietic Stem Cell Fate

September 16, 2024

[Trends In Cell Biology] The authors review our current understanding of epigenetic regulation in the establishment and maintenance of HSC fate decisions under different physiological conditions.

ISB 2001 Trispecific T Cell Engager Shows Strong Tumor Cytotoxicity and Overcomes Immune Escape Mechanisms of Multiple Myeloma Cells

September 13, 2024

[Nature Cancer] To determine an optimal first-in-human dose for the ongoing clinical trial of evaluating safety and anti-myeloma activity of ISB 2001 in participants with relapsed/refractory multiple myeloma, researchers developed an innovative quantitative systems pharmacology model leveraging preclinical data.

Autoantigen-Specific CD4+ T Cells Acquire an Exhausted Phenotype and Persist in Human Antigen-Specific Autoimmune Diseases

September 10, 2024

[Immunity] The authors characterized autoantigen-specific CD4+ T helper cells in human autoimmune diseases with defined autoantigens by combining human leukocyte antigen-tetramer-based and activation-based multidimensional ex vivo analyses.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.