Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

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Five Global Teams Awarded $125 Million to Take on the Toughest Challenges at the Frontiers of Cancer Science

March 6, 2026

[Cancer Grand Challenges (Business Wire)] Cancer Grand Challenges, a global initiative co-founded by the National Cancer Institute in the US and Cancer Research UK, announced a major $125m commitment to propel cancer research into uncharted territory.

Blackstone Life Sciences Announces a Co-Funding Agreement for Acute Myeloid Leukemia

March 3, 2026

[Blackstone Life Sciences] Blackstone Life Sciences announced a research and development funding agreement to advance the clinical development of bleximenib (JNJ-75276617), an investigational oral menin inhibitor, for AML.

Bnip3lb-Driven Mitophagy Maintains Fate of the Embryonic Hematopoietic Stem Cell Pool

March 3, 2026

[Nature Communications] The authors showed that newly specified hematopoietic stem and progenitor cells (HSPCs) achieve this unique state by precise spatio-temporal regulation of reactive oxygen species via Bnip3lb-associated developmentally-programmed mitophagy, a distinct autophagic regulatory mechanism from that of adult HSPCs.

Porous Microscaffold Enables Spontaneous Hematopoietic Cell Differentiation and Continuous Macrophage Production from hPSCs for Therapy

March 3, 2026

[Biomaterials] Investigators presented a porous microscaffold that enables robust hematopoietic differentiation from human pluripotent stem cell-derived mesoderm.

Mutant SRSF2-Associated Impaired Erythropoiesis Is Defined by Increased mTORC1 Signaling Due to FYN Missplicing

March 3, 2026

[Leukemia] Using mouse models and primary human samples, researchers investigated the impact of SRSF2 mutations on erythropoiesis. They found reduced erythropoiesis in Srsf2^P95H versus wild-type mice upon stress-induced erythropoiesis.

In Vivo Modeling of Stress Erythropoiesis through Targeted Gene Editing of Rat Hematopoietic Stem Cells

March 3, 2026

[Blood Advances] To explore the regulation of erythropoiesis in the bone marrow in response to anemia, investigators studied the role of E-cadherin in the erythroid lineage of rats.

GATA1 Drives Human Erythropoiesis via Liquid-Liquid Phase Separation

March 3, 2026

[FASEB Journal] Researchers showed that GATA1 forms dynamic nuclear condensates in HEK293T, HUDEP2 progenitors, and erythroleukemia cells, as well as concentration-dependent droplets in vitro.

Targeting ABCD1 Inhibits Peroxisomal Fatty Acid Oxidation to Selectively Eliminate Acute Myeloid Leukemia Cells

March 3, 2026

[Blood] Investigators demonstrated that AML cells upregulate the peroxisomal very-long-chain fatty acid transporter ABCD1 and increase endogenous levels of peroxisomal fatty acid oxidation relative to healthy hematopoietic cells.

IMPDH Inhibition Enhances Cytarabine Efficacy in SAMHD1-Expressing Leukaemia Cells via Guanine Nucleotide Depletion

March 3, 2026

[Molecular Oncology] Scientists showed that approved drugs inhibiting inosine-5′-monophosphate dehydrogenase (IMPDH)—mycophenolic acid and ribavirin—imbalance deoxyribonucleoside triphosphate pools and increase ara-C efficacy in SAMHD1-proficient, but not deficient, leukaemic cells.

Potential Utility of PPARγ Agonists in Targeting Chronic Myeloid Leukemia Stem Cells

March 3, 2026

[Annals of Hematology] Researchers investigated the impact of adding pioglitazone to imatinib therapy in 26 newly diagnosed chronic-phase chronic myeloid leukemia patients. Results suggested that pioglitazone may enhance early molecular response and suppress leukemia stem cells-associated genes.

Aging through the Looking-Glass: The Different Flavours of Clonal Haematopoiesis

March 3, 2026

[Aging Cell] Scientists provide an overview of the current literature on intersections of different forms of clonal haematopoiesis (CH), the clinical implications of these, and a perspective on how CH enhances our understanding of the biology of aging.

A STAT3 Degrader Demonstrates Efficacy in Venetoclax Resistant Acute Myeloid Leukemia

February 17, 2026

[Leukemia] Scientists showed overexpression of signal transducer and activator of transcription 3 (STAT3) alone in a transgenic murine model induces a myeloid malignancy with a short latency period and inflammatory upregulation supporting STAT3’s role in inducing leukemogenesis.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.