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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Mitochondrial Abnormalities as a Target of Intervention in Acute Myeloid Leukemia
[Frontiers In Oncology] The authors discuss the dual role mitophagy plays in AML survival, the importance of targeting mitophagy to treat AML, and current progress in the area.
FLT3 is Genetically Essential for ITD-Mutated Leukemic Stem Cells but Dispensable for Human Hematopoietic Stem Cells
[Blood] Scientists established FLT3 as an ideal therapeutic target where ITD+ leukemic stem cells were eradicated upon FLT3 deletion, while HSCs were spared.
Rigel’s Fostamatinib Being Studied by National Institute of Health in Patients with Sickle Cell Disease
[Rigel Pharmaceuticals, Inc.] Rigel Pharmaceuticals, Inc. announced the first patient has been enrolled in a Phase 1 study evaluating the safety and tolerability of escalating doses of fostamatinib, the company's oral spleen tyrosine kinase inhibitor, in patients with sickle cell disease.
Human Oncostatin M Deficiency Underlies an Inherited Severe Bone Marrow Failure Syndrome
[Journal of Clinical Investigation] The authors identified three young individuals from a consanguineous family presenting with inherited severe bone marrow failure syndromes characterized by profound anemia, thrombocytopenia, and neutropenia.
Inhibition of DEK Restores Hematopoietic Stem Cell Function in Fanconi Anemia
[Journal of Experimental Medicine] Scientists reported that HSCs relaxed the global chromatin by downregulating the expression of a chromatin architectural protein, DEK, in response to replication stress.
Olutasidenib in Combination with Azacitidine Induces Durable Complete Remissions in Patients with Relapsed or Refractory mIDH1 Acute Myeloid Leukemia: A Multicohort Open-Label Phase I/II...
[Journal of Hematology & Oncology] Investigators presented a pooled analysis from multiple cohorts of the Phase I/II trial of patients with relapsed/refractory AML who received combination olutasidenib and azacitidine therapy.
An Epigenetic Pathway Regulates MHC-II Expression and Function in B Cell Lymphoma Models
[Journal of Clinical Investigation] Scientists elucidated how BRCA1 associated protein 1 (BAP1) was involved in transcriptional regulation of MHC-II expression and how BAP1 impacted B cell lymphoma tumor growth via regulating tumor microenvironment and immune cell infiltration.
Generating Allogeneic CAR-NKT Cells for Off-the-Shelf Cancer Immunotherapy with Genetically Engineered HSP Cells and Feeder-Free Differentiation Culture
[Nature Protocols] Researchers introduced an ex vivo feeder-free culture method to differentiate gene-engineered hematopoietic stem and progenitor cells into allogeneic invariant natural killer T cells and their CAR-armed derivatives.
Common Hereditary Variants of the APOE Gene and Posttransplant Outcome in Acute Myeloid Leukemia
[Blood] Researchers performed apolipoprotein E (APOE) genotyping in two contemporary cohorts of 348 and 447 patients with AML who had received allogeneic HSCT and evaluated associations of recipient and donor APOE genetic variation with posttransplant outcome.
Precision Medicine for High-Risk Gene Fusions in Pediatric AML: A Focus on KMT2A, NUP98, and GLIS2 Rearrangements
[Blood] The authors discuss the current molecular landscape and functional characterization of three of the most lethal childhood AML fusion-oncogene driven subtypes harboring KMT2A, NUP98, or CBFA2T3::GLIS2 rearrangements.
CPSF6-RARγ Interacts with Histone Deacetylase 3 to Promote Myeloid Transformation in RARG-Fusion Acute Myeloid Leukemia
[Nature Communications] Using the most prevalent retinoic acid receptor gamma (RARG) fusion, CPSF6-RARG (CR), as a representative, scientists revealed that the CR fusion, enhanced the expansion of myeloid progenitors, impaired their maturation and synergized with RAS mutations to drive more aggressive myeloid malignancies.
Oncogenic Role of RARG Rearrangements in Acute Myeloid Leukemia Resembling Acute Promyelocytic Leukemia
[Nature Communications] Scientists showed that RARG fusions disrupted myeloid differentiation and promoted proliferation and self-renewal of hematopoietic stem and progenitor cells by upregulating BCL2 and ATF3.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
