Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Unrelated Umbilical Cord Blood Can Improve the Prognosis of Haploidentical Hematopoietic Stem Cell Transplantation

[Stem Cell Research & Therapy] Researchers showed that neither acute graft versus host disease (aGVHD) nor chronic GVHD was increased in the umbilical cord blood-haplo hematopoietic stem cell transplantation group, and the engraftment and infection rates were similar between the two groups.

A Primary Hierarchically Organized Patient-Derived Model Enables in Depth Interrogation of Stemness Driven by the Coding and Non-Coding Genome

[Leukemia] Through classical flow sorting and functional analyses, researchers established that a single phenotypic population was highly enriched for leukemic stem cells (LSC). The LSC fraction could be easily isolated and serially expanded in culture or in xenografts while faithfully recapitulating functional, transcriptional and epigenetic features of primary LSCs.

The Genesis and Evolution of Acute Myeloid Leukemia Stem Cells in the Microenvironment: From Biology to Therapeutic Targeting

[Cell Death Discovery] Scientists discuss the relationship between leukeumic stem cells (LSCs), the bone marrow microenvironment, and how understanding the generation and evolution laws of LSCs can facilitate the development of effective therapeutic targets.

Bmi1 Suppresses Protein Synthesis and Promotes Proteostasis in Hematopoietic Stem Cells

[Genes & Development] Researchers deleted Bmi1 from adult hematopoietic cells and found that this slowly depleted HSCs. Rather than inducing senescence, Bmi1 deficiency increased HSC division.

Graphdiyne Oxide Nanosheets Display Selective Anti-Leukemia Efficacy Against DNMT3A-Mutant AML Cells

[Nature Communications] Scientists demonstrated that cell adhesion-related genes were predominantly enriched in DNMT3A-mutant AML cells and identify that graphdiyne oxide displayed an anti-leukemia effect specifically against these mutated cells.

Sleep Exerts Lasting Effects on Hematopoietic Stem Cell Function and Diversity

[Journal of Experimental Medicine] Researchers showed that sleep interruption restructures the epigenome of hematopoietic stem and progenitor cells and increased their proliferation, thus reducing hematopoietic clonal diversity through accelerated genetic drift.

Splenic Red Pulp Macrophages Provide a Niche for CML Stem Cells and Induce Therapy Resistance

[Leukemia] Investigators demonstrated that leukemia stem cells preferentially accumulated in the spleen and contribute to disease progression.

ABAT Gene Expression Associated with the Sensitivity of Hypomethylating Agents in Myelodysplastic Syndrome Through CXCR4/mTOR Signaling

[Cell Death Discovery] It was found that ABAT gene interference increased the sensitivity of HL-60 and THP-1 cells to HMAs treatment, while ABAT overexpression decreased its sensitivity.

Genetically Modified CD7-Targeting Allogeneic CAR-T Cell Therapy With Enhanced Efficacy for Relapsed/Refractory CD7-Positive Hematological Malignancies: A Phase I Clinical Study

[Cell Research] The authors developed healthy donor-derived, CD7-targeting CAR-T cells with genetic modifications to resist fratricide, graft-veruss-host disease and allogeneic rejection, as well as to potentiate antitumor function.

Allogeneic Hematopoietic Cell Transplantation in Patients with Juvenile Myelomonocytic Leukemia in Korea: A Report of the Korean Pediatric Hematology-Oncology Group

[Bone Marrow Transplantation] This multicenter study evaluated the characteristics, outcomes, and prognostic factors of allogeneic hematopoietic cell transplantation (HCT) in recipients with JMML who were diagnosed between 2000 and 2019 in Korea.

Protein Arginine Methyltransferase 1 in the Generation of Immune Megakaryocytes: A Perspective Review

[Journal of Biological Chemistry] Advances in single-cell RNA sequencing analysis from several studies have revealed that bone marrow Megakaryocytess are heterogeneous and can be clustered into three–four subpopulations: a subgroup that is adjacent to the hematopoietic stem cells, a subgroup expressing genes for platelet biogenesis, and a subgroup expressing immune-responsive genes.

Platelet–Acute Leukemia Interactions

[Clinica Chimica Acta] The authors discusses the changes occurring in platelet count, mean platelet volume, platelet distribution width, reticulated platelets, platelet membrane glycoprotein, platelet aggregation, and activation in acute leukemia patients.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.