Stabilization of Fatty Acid Synthesis Enzyme Acetyl-CoA Carboxylase 1 Suppresses Acute Myeloid Leukemia Development

Stable ACC1 protein expression suppressed the growth-promoting activity and increased ROS levels with the consumption of NADPH in a primary bone marrow culture, and delayed the onset of acute myeloid leukemia with increases in mature myeloid cells in mouse models.
[Journal of Clinical Investigation]
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Core Binding Factor Acute Myelogenous Leukemia-2021 Treatment Algorithm

The authors discussed the effective implementation of available therapeutic measures and appropriate disease monitoring of core binding factor acute myelogenous leukemia.
[Blood Cancer Journal]
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Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Suppressive Myeloid Cell Production from Hematopoietic Progenitors In Vitro

To examine the ontogeny and function of MS1 cells, researchers developed a cellular model for inducing CD14+ MS1 monocytes from healthy bone marrow hematopoietic stem and progenitor cells.
[Science Translational Medicine]
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Development of β-Globin Gene Correction in Human Hematopoietic Stem Cells as a Potential Durable Treatment for Sickle Cell Disease

Researchers demonstrated the preclinical feasibility, efficacy, and toxicology of the β-globin gene correction in plerixafor-mobilized CD34+ cells from healthy and sickle cell disease patient donors.
[Science Translational Medicine]
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Association of Convalescent Plasma Therapy with Survival in Patients with Hematologic Cancers and COVID-19

In this cohort study of 966 patients with hematologic cancer and COVID-19, after adjustment for potential confounding factors, convalescent plasma treatment was associated with a significantly improved 30-day mortality in the 143 individuals who received it.
[JAMA Oncology]
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Tumor Cells in Light-Chain Amyloidosis and Myeloma Show Different Transcriptional Rewiring of Normal Plasma Cell Development

The authors defined a transcriptional atlas of normal plasma cell (PC) development in secondary lymphoid organs, peripheral blood and bone marrow for comparison with the transcriptional programs of tumor PCs in amyloidosis and multiple myeloma.
[Blood]
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The HCK/BTK Inhibitor KIN-8194 Is Active in MYD88 Driven Lymphomas and Overcomes Mutated BTKCys481 Ibrutinib Resistance

Scientists performed an extensive medicinal chemistry campaign and identified KIN-8194 as a novel dual inhibitor of HCK and BTK. KIN-8194 showed potent and selective in vitro killing of MYD88 mutated lymphoma cells, including ibrutinib resistant BTKCys481Ser expressing cells.
[Blood]
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M2 Macrophages, but Not M1 Macrophages, Support Megakaryopoiesis by Upregulating PI3K-AKT Pathway Activity

Aberrant bone marrow-M1/M2 MФ polarization, characterized by increased M1 MФs and decreased M2 MФs and accompanied by impaired megakaryopoiesis-supporting abilities, was found in patients with thrombocytopenia post-allotransplant.
[Signal Transduction and Targeted Therapy]
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CHIP & HIPs: Clonal Hematopoiesis Is Common in Hip Arthroplasty Patients and Associates with Autoimmune Disease

The authors prospectively investigated frequency and clinical associations of clonal hematopoiesis (CH) in 200 patients without known hematologic disease undergoing total hip arthroplasty. Prevalence of CH was 50%, including 77 patients with CH of indeterminate potential, and 23 patients harboring CH with lower mutation burden.
[Blood]
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3D Genome Alterations Associated with Dysregulated HOXA13 Expression in High-Risk T-Lineage Acute Lymphoblastic Leukemia

Investigators reported an integrated analysis of 3D genome alterations and differential gene expressions in eighteen newly diagnosed T-lineage acute lymphoblastic leukemia patients and four healthy controls. Patients with HOXA11-A13 expressions, but not other genes in the HOXA cluster, had immature immunophenotype and poor outcomes.
[Nature Communications]
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Inflammation as a Regulator of Hematopoietic Stem Cell Function in Disease, Aging, and Clonal Selection

Investigators review how major sources of systemic inflammation act on and subsequently shape HSCs fate and function. They highlight how lifelong inflammatory exposure contributes to HSC inflammatory-aging and selection of premalignant HSC clones.
[Journal of Experimental Medicine]
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