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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
FGF18 Mediates Fibroblast-Leukemia Crosstalk to Promote Acute Myeloid Leukemia Progression
[Blood] Investigators identified fibroblast‑derived fibroblast growth factor 18 (FGF18) as a novel stromal cytokine that reprograms leukemia-immune interactions.
Menin-MLL Inhibitors Enhance JUND Activity in MLLr Leukemic Cells Contributing to Tumorigenesis and Therapy Resistance
[Blood] Researchers identified JUND as a driver of resistance to menin–MLL inhibitors in MLL-rearranged leukemia, revealing a promising combination strategy to improve therapeutic responses.
Local Oxygen Tension Dictates Hematopoietic Cell Growth and Potency
[Leukemia] Scientists showed that local oxygen levels regulate hematopoietic stem cell growth and potency, identifying oxygen-sensing pathways and PRSS2 as potential targets to improve blood stem cell therapies.
Choline-Dependent Methionine Metabolism Supports Leukemia Progression
[Communications Biology] Using a leukemia suppression model and CRISPR screening, the authors found that the choline transporter SLC44A1 is overexpressed in leukemia patients and impacts leukemogenesis.
Arsenic Exposure Disrupts Human Hematopoiesis by Impairing the Generation and Function of Hematopoietic Stem and Progenitor Cells
[Environmental Toxicology and Pharmacology] Using human iPSCs, investigators examined how sodium arsenite affects the formation of hematopoietic stem and progenitor cells, which are essential for lifelong blood production.
Orelabrutinib Versus Chemoimmunotherapy in Treatment-NaïVe Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Randomized, Phase III Trial
[Signal Transduction and Targeted Therapy] Scientists demonstrated that orelabrutinib significantly improves progression-free survival and response rates over chemoimmunotherapy as a first-line treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma.
CD7 Chimeric Antigen Receptor T Cells in Patients with Relapsed or Refractory CD7-Positive Acute Myeloid Leukemia
[Leukemia] This phase I clinical trial evaluated CD7-targeted CAR-T cell therapy in patients with relapsed/refractory CD7-positive AML. Patients received a single infusion of autologous or donor-derived CD7 CAR-T cells using a standard 3 + 3 dose escalation design across two dose levels
Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms
[Cancer Science] The authors highlight how splicing factor mutations shape clonal hematopoiesis and drive progression toward myeloid neoplasms, revealing age-dependent mechanisms of clonal expansion and leukemogenesis.
Orca Bio’s TREGZI™ Receives US FDA Approval as First and Only Precision-Engineered Cell Therapy for Allogeneic Transplant in Adults with Hematological Malignancies
[Orca Bio] Orca Bio announced FDA approval of TREGZI™ (Orca-T®), a precision-engineered cell therapy for matched-donor hematopoietic stem cell transplantation in adults with hematologic malignancies, designed to improve chronic graft-versus-host disease-free survival.
Mutation-Dependent Responses to Sleep and Exercise in Clonal Haematopoiesis
[Nature] In humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, researchers demonstrated mutation-dependent responses to sleep and exercise in clonal haematopoiesis and showed that mutant cells are uniquely sensitive to lifestyle.
Targeting the METTL1/M7g Axis As a Therapeutic Strategy in Myeloid Leukemia
[Blood] Scientists identified METTL1 as a key regulator of leukemia stem cell self-renewal and homing within bone marrow microenvironment through catalyzing m7G formation on a specific tRNA, tRNAPheGAA, thereby promoting leukemogenesis.
Targeting STAT3-Mediated Lipid Metabolism Reprogramming Overcomes Chemoresistance in Acute Myeloid Leukemia
[Cell Death & Disease] Researchers found that multiple lipid metabolism processes are aberrantly activated in Ara-C resistant AML cells, accompanied by upregulation of JAK-STAT3 signaling and key lipid metabolic regulators, notably SREBP1 and CPT2.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
