Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Lymphoid Cell Development from Fetal Hematopoietic Progenitors and Human Pluripotent Stem Cells

[Immunological Reviews] The authors examine lymphoid development from non-hematopoietic stem cell progenitor cells and technological advances in the differentiation of human lymphoid cells from PSCs for clinical translation.

Human T Cell Generation Is Restored in CD3δ Severe Combined Immunodeficiency through Adenine Base Editing

[Cell] Delivery of mRNA encoding a laboratory-evolved adenine base editing and guide RNA into a CD3δ severe combined immunodeficiency patient’s hematopoietic stem and progenitor cells resulted in a 71.2% ± 7.85% correction of the pathogenic mutation.

Clonal Hematopoiesis and Dysregulation of the Immune System

[Nature Reviews Immunology] Scientists review the observational and mechanistic studies describing the connection between clonal hematopoiesis (CH) and pathological immune dysfunction, the effects of CH-associated genetic alterations on the function of myeloid and lymphoid cells, and the clinical and therapeutic implications of CH as a target for immunomodulation.

Single-Cell Dissection of Human Hematopoietic Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

[Science Immunology] Using single cell transcriptomics, scientists longitudinally profiled bone marrow and blood samples from patients with aplastic anemia undergoing allogeneic HSC transplantation with G-CSF–mobilized grafts.

Hematopoietic Stem Cells Preferentially Traffic Misfolded Proteins to Aggresomes and Depend on Aggrephagy to Maintain Protein Homeostasis

[Cell Stem Cell] Investigators showed that in contrast to most cells that primarily utilize the proteasome to degrade misfolded proteins, HSCs preferentially traffic misfolded proteins to aggresomes in a Bag3-dependent manner and depend on aggrephagy, a selective form of autophagy, to maintain proteostasis in vivo.

Targeting Pleckstrin-2/Akt Signaling Reduces Proliferation in Myeloproliferative Neoplasm Models

[Journal Of Clinical Investigation] Researchers revealed a Plek2/Akt complex that drove cell proliferation and could be targeted by a class of antiproliferative compounds for myeloproliferative neoplasm therapy.

m6A-Driven SF3B1 Translation Control Steers Splicing to Direct Genome Integrity and Leukemogenesis

[Molecular Cell] Scientists identified a conserved epitranscriptomic program that steers SF3B1 levels to counteract leukemogenesis. Their analysis of human and murine pre-leukemic myelodysplastic syndrome (MDS) cells revealed dynamic regulation of SF3B1 protein abundance, which affected MDS-to-leukemia progression in vivo.

The Novel GATA1-Interacting Protein HES6 Is an Essential Transcriptional Cofactor for Human Erythropoiesis

[Nucleic Acids Research] Through gene expression profiling, investigators found HES6 as an abundant cofactor expressed at gene level during human erythropoiesis.

Myeloid Cells from Langerhans Cell Histiocytosis Patients Exhibit Increased Vesicle Trafficking and an Altered Secretome Capable of Activating NK Cells

[Haematologica] Scientists used an in vitro differentiation system and RNA-sequencing to compare monocyte-derived dendritic cells from Langerhans cell histiocytosis patients to those derived from healthy controls or patients with Crohn’s disease, a non-histiocytic inflammatory disease.

The Menin Inhibitor Revumenib in KMT2A-Rearranged or NPM1-Mutant Leukemia

[Nature] Researchers described the results of the first-in-human Phase I clinical trial investigating revumenib, a potent and selective oral inhibitor of the menin–KMT2A interaction, in patients with relapsed or refractory acute leukemia.

BCL7A Is Silenced by Hypermethylation to Promote Acute Myeloid Leukemia

[Biomarker Research] Scientists studied the switch/sugar non-fermenting (SWI/SNF) subunit BCL7A, which was found to be recurrently mutated in lymphomas, but whose role in acute myeloid malignancies is currently unknown.

Clonal Hematopoiesis and Dysregulation of the Immune System

[Oncotargets And Therapy] The authors focus on the burden of relapsed/refractory pediatric B cell acute lymphoblastic leukemia (B-ALL), the limitations of current strategies, the emerging paradigms for the role of CAR-T in r/r B-ALL, the local perspectives on the health economics and future direction of CAR-T therapies in pediatric patients.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.