Stable ACC1 protein expression suppressed the growth-promoting activity and increased ROS levels with the consumption of NADPH in a primary bone marrow culture, and delayed the onset of acute myeloid leukemia with increases in mature myeloid cells in mouse models.
[Journal of Clinical Investigation]
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The authors discussed the effective implementation of available therapeutic measures and appropriate disease monitoring of core binding factor acute myelogenous leukemia.
[Blood Cancer Journal]
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To examine the ontogeny and function of MS1 cells, researchers developed a cellular model for inducing CD14+ MS1 monocytes from healthy bone marrow hematopoietic stem and progenitor cells.
[Science Translational Medicine]
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Researchers demonstrated the preclinical feasibility, efficacy, and toxicology of the β-globin gene correction in plerixafor-mobilized CD34+ cells from healthy and sickle cell disease patient donors.
[Science Translational Medicine]
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In this cohort study of 966 patients with hematologic cancer and COVID-19, after adjustment for potential confounding factors, convalescent plasma treatment was associated with a significantly improved 30-day mortality in the 143 individuals who received it.
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The authors defined a transcriptional atlas of normal plasma cell (PC) development in secondary lymphoid organs, peripheral blood and bone marrow for comparison with the transcriptional programs of tumor PCs in amyloidosis and multiple myeloma.
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Scientists performed an extensive medicinal chemistry campaign and identified KIN-8194 as a novel dual inhibitor of HCK and BTK. KIN-8194 showed potent and selective in vitro killing of MYD88 mutated lymphoma cells, including ibrutinib resistant BTKCys481Ser expressing cells.
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Aberrant bone marrow-M1/M2 MФ polarization, characterized by increased M1 MФs and decreased M2 MФs and accompanied by impaired megakaryopoiesis-supporting abilities, was found in patients with thrombocytopenia post-allotransplant.
[Signal Transduction and Targeted Therapy]
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The authors prospectively investigated frequency and clinical associations of clonal hematopoiesis (CH) in 200 patients without known hematologic disease undergoing total hip arthroplasty. Prevalence of CH was 50%, including 77 patients with CH of indeterminate potential, and 23 patients harboring CH with lower mutation burden.
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Investigators reported an integrated analysis of 3D genome alterations and differential gene expressions in eighteen newly diagnosed T-lineage acute lymphoblastic leukemia patients and four healthy controls. Patients with HOXA11-A13 expressions, but not other genes in the HOXA cluster, had immature immunophenotype and poor outcomes.
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Investigators review how major sources of systemic inflammation act on and subsequently shape HSCs fate and function. They highlight how lifelong inflammatory exposure contributes to HSC inflammatory-aging and selection of premalignant HSC clones.
[Journal of Experimental Medicine]
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