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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
A Novel Snake Venom C-Type Lectin-Like Protein Modulates Blood Coagulation by Targeting Von Willebrand Factor and Coagulation Factor IX
[Scientific Reports] A novel C-type lectin-like proteins, termed protocetin, with molecular weight of 29.986 kDa, was purified from the Protobothrops mucrosquamatus venom. It consists of α- and β-chains, with 67% similarity in their N-terminal sequence.
Classification and Risk Stratification in T-Lineage Acute Lymphoblastic Leukemia
[Blood] Investigators highlight ongoing efforts to identify reliable prognostic biomarkers and underscores the potential of genomics-based classification to guide future T-ALL treatment strategies.
Mucosal-Associated Invariant T Cells Are Functionally Impaired in Pediatric and Young Adult Patients Following Allogeneic Hematopoietic Stem Cell Transplantation and Their Recovery Correlates with...
[Haematologica] Investigators retrospectively studied Mucosal-associated invariant T (MAIT)-cell recovery in 145 consecutive children and young adults with hematologic malignancies undergoing allogeneic-HSCT between April 2019 and May 2022, from unrelated matched donor, with standard graft-versus-host-disease prophylaxis, or HLA-haploidentical donor after in vitro αβT/CD19-cell depletion, without post-HSCT pharmacological prophylaxis.
Clonal Hematopoiesis and Hematological Malignancy
[Journal of Clinical Investigation] The authors give an overview of the spectrum of clonal hematopoiesis driver mutations, what is known about their pathophysiology, and how this informs the risk of incident myeloid malignancy.
Catherine Robin Receives Grant for Reducing Animal Experiments
[Hubretch Institute] Catherine Robin, group leader at the Hubrecht Institute, has received a grant from the KNAW 3R-fund. This fund supports research aimed at reducing, refining, or replacing the use of animals in scientific studies.
Cellular Taxonomy of the Preleukemic Bone Marrow Niche of Acute Myeloid Leukemia
[Leukemia] Using our AML-murine model, researchers performed single-cell RNA-sequencing of preleukemic BMM cells. They found normal HSC-regulating LepR+ mesenchymal stem cells, and endothelial cells were decreased, along with increases in CD55+ fibroblasts and pericytes.
RNA m5C Oxidation by TET2 Regulates Chromatin State and Leukaemogenesis
[Nature] Investigators showed that chromatin-associated retrotransposon RNA 5-methylcytosine (m5C) can be recognized by the methyl-CpG-binding-domain protein MBD6, which guided deubiquitination of nearby monoubiquitinated Lys119 of histone H2A to promote an open chromatin state.
MERTK Inhibition Selectively Activates a DC–T-Cell Axis to Provide Anti-Leukemia Immunity
[Leukemia] Host Mertk knock-out or MERTK inhibitor MRX-2843 increased CD8α+ dendritic cells with enhanced antigen-presentation capacity in the leukemia microenvironment and inhibited leukemogenesis.
Impact of Soluble BCMA and Non-T-Cell Factors on Refractoriness to BCMA-Targeting T-Cell Engagers in Multiple Myeloma
[Blood] Scientists leveraged whole genome sequencing and in vitro assays to demonstrate that soluable (s)BCMA may independently predict primary refractoriness to anti-BCMA therapies. In addition to sBCMA, tumor burden and surface BCMA antigen density collectively influence anti-BCMA TCE cytotoxic efficacy.
MERTK Inhibition Selectively Activates a DC–T Cell Axis to Provide Anti-Leukemia Immunity
[Leukemia] Scientists probed anti-leukemia immune mechanisms and evaluated roles for TYRO3 and AXL in the leukemia microenvironment. Host Mertk knock-out or MERTK inhibitor MRX-2843 increased CD8α+ dendritic cells with enhanced antigen-presentation capacity in the leukemia microenvironment and inhibited leukemogenesis.
The Present and Future for CAR-T Cell Therapy in Adult B Cell ALL
[Blood] Overall, CAR-T therapy signifies a paradigm shift in B-ALL management, with the potential for improved remission and survival in a historically challenging patient population.
Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia
[Blood] Investigators described a novel mechanism of oncogene activation whereby focal copy number loss of an intronic element within the FTO gene led to aberrant expression of IRX3, an oncogene in T cell acute lymphoblastic leukemia
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
