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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
MAFB: A Key Regulator of Myeloid Commitment Involved in Hematological Diseases
[Cell Death Discovery] The authors summarize current knowledge on both physiological and pathological roles of MAFB and highlight the impact of its deregulation on hematological cancer initiation and progression.
TP53-Mutant Variant Allele Frequency and Cytogenetics Determine Prognostic Groups in MDS/AML for Transplantation
[Blood Advances] The authors analyzed 240 patients with TP53-mutated myelodysplastic syndrome (MDS) or AML who underwent HSC transplantation.
Microbial Cancer Immunotherapy Reprograms Hematopoiesis to Enhance Myeloid-Driven Anti-Tumor Immunity
[Cancer Cell] Scientists demonstrated that Bacillus Calmette-Guérin administered in the bladder colonizes the bone marrow and, in both mice and humans, reprograms HSPCs to alter and amplify myelopoiesis.
Human Autoimmunity at Single Cell Resolution in Aplastic Anemia before and after Effective Immunotherapy
[Nature Communications] To better understand its pathophysiology, researchers applied advanced single cell methodologies, including mass cytometry, single-cell RNA, and TCR/BCR sequencing, to patient samples from a clinical trial of immunosuppression and growth factor stimulation.
SMYD3 Activates Fatty Acid β-Oxidation to Promote Self-Renewal of Leukemia Stem Cells
[Cancer Research] Researchers validated the critical role of the histone methyltransferase SET and MYND domain-containing 3 (SMYD3) in the maintenance of leukemia stem cells in chronic myeloid leukemia.
Novel Roles for CREG1 in Hematopoiesis Revealed by Single-Cell RNA Sequencing
[Cell & Bioscience] Researchers utilized single-cell RNA sequencing (scRNA-seq) to investigate the function of cellular repressor of E1A stimulated genes 1 (CREG1) in hematopoietic development in adult zebrafish.
The Transcription Factor HOXA9 Induces Expression of the Chromatin Modifier SMYD3 to Drive Leukemogenesis
[Journal of Biological Chemistry] Scientists identified that SET and MYND domain-containing protein 3 (SMYD3) was overexpressed in acute myeloid leukemia (AML) and predicted a poor prognosis for AML patients.
SFRP1 and SFRP2 Jointly Regulate Normal and Malignant Hematopoietic Progenitors by Influencing Mesenchymal Cells in the Hematopoietic Niche
[Biochemical and Biophysical Research Communications] Researchers showed that secreted frizzled-related proteins 1/2 (SFRP1/2) functions as a niche factor for both normal and malignant HSPCs by acting on mesenchymal stromal cells.
FOXP1 Contributes to Murine Hematopoietic Stem Cell Functionality
[Experimental Hematology] Investigators showed that loss of hematopoietic-specific factor forkhead box P1 (FOXP1) expression leads to attrition of the HSC and multipotent progenitor (MPP)-1 compartment in parallel with enhancement of myeloid-biased MPP3 in adult bone marrow and fetal liver.
Myeloablative Radioligand Therapy Targeting C-X-C Motif Chemokine Receptor 4 in Advanced Multiple Myeloma
[Clinical Nuclear Medicine] Scientists determined the myeloablative efficacy of C-X-C motif chemokine receptor 4 (CXCR4) radioligand therapy in multiple myeloma patients and assessed the safety profile of this treatment.
Effect of Supplementation with Vitamin D on Biochemical Markers of Iron Status and Erythropoiesis in Older People: BEST-D Trial
[British Journal of Nutrition] Using placebo-controlled randomization, investigators assessed the effects of supplementation with vitamin D on biochemical markers of iron status and erythropoiesis in community-dwelling older people living in the United Kingdom.
Intra-Bone Marrow Diversity of Endothelial Cells and Its Impact on Hematopoietic Stem Cell Development and Maintenance
[Experimental Hematology] The authors provide an overview of the bone marrow vasculature and discuss how the heterogeneous vasculature contributes to bone formation and HSC maintenance.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
