Category Archives: Hematopoiesis

Hematopoiesis News is an online publication and email newsletter that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
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Hematopoiesis News is a weekly newsletter in which we curate the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.

In Vitro Comparison of the Effects of Imatinib and Ponatinib on Chronic Myeloid Leukemia Progenitor/Stem Cell Features

Researchers compared the effects of tyrosine kinase inhibitors belonging to different generations, imatinib and ponatinib, on progenitor/stem cell expansion potential and markers.
[Targeted Oncology]
Tusa, I., Cheloni, G., Poteti, M., Silvano, A., Tubita, A., Lombardi, Z., Gozzini, A., Caporale, R., Scappini, B., Dello Sbarba, P., & Rovida, E. (2020). In Vitro Comparison of the Effects of Imatinib and Ponatinib on Chronic Myeloid Leukemia Progenitor/Stem Cell Features. Targeted Oncology. https://doi.org/10.1007/s11523-020-00741-x Cite
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A Novel Approach to Genetic Engineering of T-Cell Subsets by Hematopoietic Stem Cell Infection with a Bicistronic Lentivirus

Designed novel lentiviral constructs harbored a global promoter regulating mCherry for hematopoietic stem cell selection and a T-cell specific promoter upstream of eGFP.
[Scientific Reports]
Bogert, N. V., Furkel, J., Din, S., Braren, I., Eckstein, V., Müller, J. A., Uhlmann, L., Katus, H. A., & Konstandin, M. H. (2020). A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus. Scientific Reports, 10(1), 13740. https://doi.org/10.1038/s41598-020-70793-6 Cite
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Autologous Hematopoietic Stem Cell Transplantation for Refractory Stiff-Person Syndrome: The UK Experience

Autologous hematopoietic stem cell transplantation was an intensive but well tolerated and effective treatment option for patients with Stiff Person Syndrome refractory to conventional immunotherapy.
[Journal of Neurology]
Kass-Iliyya, L., Snowden, J. A., Thorpe, A., Jessop, H., Chantry, A. D., Sarrigiannis, P. G., Hadjivassiliou, M., & Sharrack, B. (2020). Autologous haematopoietic stem cell transplantation for refractory stiff-person syndrome: the UK experience. Journal of Neurology. https://doi.org/10.1007/s00415-020-10054-8 Cite
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A Novel Approach to Genetic Engineering of T-Cell Subsets by Hematopoietic Stem Cell Infection with a Bicistronic Lentivirus

Two T-cell specific promoters were assessed: the distal Lck—and the CD3δ-promoter. Transduced hematopoietic stem cells were FACS sorted by mCherry expression and transferred into sublethally irradiated C57/BL6 mice.
[Scientific Reports]
Bogert, N. V., Furkel, J., Din, S., Braren, I., Eckstein, V., Müller, J. A., Uhlmann, L., Katus, H. A., & Konstandin, M. H. (2020). A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus. Scientific Reports, 10(1), 13740. https://doi.org/10.1038/s41598-020-70793-6 Cite
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Group 2 Innate Lymphoid Cells Must Partner with the Myeloid–Macrophage Lineage for Long-Term Postviral Lung Disease

Scientists used a mouse model that applied an improved genetic definition of ILC2s via IL-7r–conditional Rora gene targeting and took advantage of a distinct progression from acute illness to chronic disease, based on a persistent type 2 immune response to respiratory infection with a natural pathogen.
[Journal of Immunology]
Wu, K., Wang, X., Keeler, S. P., Gerovac, B. J., Agapov, E. V., Byers, D. E., Gilfillan, S., Colonna, M., Zhang, Y., & Holtzman, M. J. (2020). Group 2 Innate Lymphoid Cells Must Partner with the Myeloid–Macrophage Lineage for Long-Term Postviral Lung Disease. The Journal of Immunology, 205(4), 1084–1101. https://doi.org/10.4049/jimmunol.2000181 Cite
AbstractGraphical Abstract

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COVID-19 Severity Associates with Pulmonary Redistribution of CD1c+ DC and Inflammatory Transitional and Nonclassical Monocytes

Investigators studied the frequencies and activation profiles of dendritic cells and monocytes present in the blood and lung of COVID-19 patients with different clinical severity in comparison with healthy individuals.
[Journal of Clinical Investigation]
Sánchez-Cerrillo, I., Landete, P., Aldave, B., Sánchez-Alonso, S., Sánchez-Azofra, A., Marcos-Jiménez, A., Ávalos, E., Alcaraz-Serna, A., Santos, I. de los, Mateu-Albero, T., Esparcia, L., López-Sanz, C., Martínez-Fleta, P., Gabrie, L., Guerola, L. del C., Fuente, H. de la, Calzada, M. J., González-Álvaro, I., Alfranca, A., … Martín-Gayo, E. (2020). COVID-19 severity associates with pulmonary redistribution of CD1c+ DC and inflammatory transitional and nonclassical monocytes. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140335 Cite
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Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding

Scientists found that differentiation-inactive, multilineage, and lineage-restricted hematopoietic stem cell clones reside in distinct regions of the transcriptional landscape of hematopoiesis.
[Cell Stem Cell]
Pei, W., Shang, F., Wang, X., Fanti, A.-K., Greco, A., Busch, K., Klapproth, K., Zhang, Q., Quedenau, C., Sauer, S., Feyerabend, T. B., Höfer, T., & Rodewald, H.-R. (2020). Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.07.018 Cite
AbstractGraphical Abstract

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Targeted Gene Correction of Human Hematopoietic Stem Cells for the Treatment of Wiskott – Aldrich Syndrome

The authors showed that a CRISPR/Cas9-based genome editing strategy allowed the precise correction of Wiskott-Aldrich syndrome mutations in up to 60% of human hematopoietic stem and progenitor cells, without impairing cell viability and differentiation potential.
[Nature Communications]
Rai, R., Romito, M., Rivers, E., Turchiano, G., Blattner, G., Vetharoy, W., Ladon, D., Andrieux, G., Zhang, F., Zinicola, M., Leon-Rico, D., Santilli, G., Thrasher, A. J., & Cavazza, A. (2020). Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome. Nature Communications, 11(1), 4034. https://doi.org/10.1038/s41467-020-17626-2 Cite
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Unrelated Cord Blood Transplantation with Myeloablative Conditioning for Pediatric Acute Lymphoblastic Leukemia in Remission: Prognostic Factors

In the total patient cohort, five-year leukemia-free survival and overall survival rates after unrelated cord blood transplantation were 61.1% and 67.7%, respectively.
[Bone Marrow Transplantation]
Abstract

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Hemogenyx Partners with UPenn to Study CAR T-Cell Therapy in AML

Hemogenyx Pharmaceuticals has inked a research agreement with the University of Pennsylvania (UPenn) for its CAR T-cell therapy for acute myeloid leukemia (AML).
[Hemogenyx Pharmaceuticals (Precision Oncology News)]
Press Release

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Celyad to Begin Phase I Trial of Donor-Derived CAR T-Cell Therapy for Multiple Myeloma

Celyad Oncology SA announced that the company’s Investigational New Drug (IND) application for CYAD-211, the company’s first-in-class short hairpin RNA-based allogeneic CAR T candidate and second non-gene edited off-the-shelf program, is in effect with the FDA.
[Celyad Oncology SA]
Press Release

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