Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
The Molecular Impact of miR-326 in Acute Lymphoblastic Leukemia and Its Cross Talk with P53
[Annals of Hematology] Scientists revealed that miR-326 exhibited a multifunctional anti-tumor behavior, affecting various aspects of drug resistance, stemness, and apoptosis in cancer, particularly in the context of acute lymphoblastic leukemia.
miR-142 Deficit in T Cells During Blast Crisis Promotes Chronic Myeloid Leukemia Immune Escape
[Nature Communications] Scientists reported on IL-6-driven miR-142 deficit occurring in T cells during blast crisis (BC) transformation. Correcting miR-142 deficit restored T cell immune activity, leading to leukemic stem cell elimination and prolonged survival of BC chronic myeloid leukemia murine models.
PSTK Inhibition Activates cGAS-STING, Precipitating Ferroptotic Cell Death in Leukemic Stem Cells
[Blood] A phenotypic CRISPR-Cas9 screen in AML identified dependence on phosphoseryl-tRNA kinase (PSTK), an atypical kinase required for the biosynthesis of all selenoproteins. In vivo, PSTK inhibition impaired AML cell growth and leukemic stem cell self-renewal.
Blockade of TSP-1/CD47 Signal Axis Promotes Donor Hematopoietic Engraftment by Improving SEC/MK Niche Function
[iScience] Researchers investigated the possibility of improving donor engraftment by blocking the thrombospondin-1 (TSP-1)/CD47 pathway in mouse models of total body irradiation-conditioned syngeneic HSC transplantation.
HMPL-306 in Relapsed or Refractory IDH1- and/or IDH2-Mutated Acute Myeloid Leukemia: A Phase I Study
[Med] This Phase I study of HMPL-306, an oral, small-molecule dual inhibitor of mutated isocitrate dehydrogenase 1/2 (mIDH1/2) investigated the safety and preliminary efficacy of HMPL-306 for the treatment of patients with relapsed/refractory acute myeloid leukemia with mIDH1/2.
MDM2 Inhibition Is Associated with the Emergence of TP53-Altered Clonal Hematopoiesis
[NPJ Precision Oncology] Scientists reported a 51-year-old female with murine double minute 2(MDM2)-amplified, TP53-wild type adenoid cystic carcinoma who was treated with a MDM2 inhibitor and developed persistent pancytopenia despite drug discontinuation.
Treatment Failure Patterns in Early Versus Late Introduction of CAR T-Cell Therapy in Large B-Cell Lymphoma
[Bone Marrow Transplantation] This study compared patterns of disease relapse and progression across patients receiving CAR-T as second-line versus third or subsequent lines. Their results indicated favorable outcomes with CAR-T irrespective of treatment line.
Targeting ABCD1-ACOX1-MET/IGF1R Axis Suppresses Multiple Myeloma
[Leukemia] Scientists revealed a specific metabolic vulnerability of multiple myeloma cells and identified a targetable axis linking very long chain fatty acid metabolism to the regulation of MET proto-oncogene (MET) and insulin-like growth factor 1 receptor (IGF1R) activity.
GATA2 Mutated Allele Specific Expression Is Associated with a Hyporesponsive State of HSC in GATA2 Deficiency Syndrome
[Blood Cancer Journal] To elucidate how GATA2 germline mutations mutations affect hematopoietic homeostasis, researchers created a knock-in mouse model expressing the recurrent Gata2 R396Q missense mutation.
Niche-Derived Semaphorin 4A Safeguards Functional Identity of Myeloid-Biased Hematopoietic Stem Cells
[Nature Aging] The authors identified an extrinsic factor, semaphorin 4A, which non-cell-autonomously conferred myeloid-biased hematopoietic stem cells resilience to inflammatory stress.
SNORD113–114 Cluster Maintains Hematopoietic Stem Cell Self-Renewal via Orchestrating the Translation Machinery
[Nature Cell Biology] Researchers performed ultra-low-input Ribo-seq in HSCs, progenitor and lineage cells, and revealed HSC-specific translated genes involved in rRNA processing.
HoxBlinc lncRNA Reprograms CTCF-Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98-Rearranged Leukemia
[Journal of Clinical Investigation] Scientists reported that a Hoxb-associated lncRNA HoxBlinc was aberrantly activated in NUP98-PHF23 fusion-driven leukemias.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.