Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Caspase 8 Deletion Causes Infection/Inflammation-Induced Bone Marrow Failure and MDS-Like Disease in Mice

[Cell Death & Disease] Caspase 8 (Casp8) is a master regulator of pyroptosis, apoptosis, and necroptosis (PANoptosis). To study the role of PANoptosis in hematopoiesis, scientists generated inducible Casp8 knockout mice.

Immunoglobulin Replacement vs Prophylactic Antibiotics for Hypogammaglobulinemia Secondary to Hematological Malignancy

[Blood Advances] In this randomized controlled feasibility trial conducted in seven hospitals in Australia and New Zealand, scientists enrolled patients with secondary hypogammaglobulinemia with either a history of recurrent/severe infection or an immunoglobulin G level less than 4 g/L.

The DMT1 Isoform Lacking the Iron-Response Element Regulates Normal and Malignant Hematopoiesis via NOTCH Pathway Activation

[FEBS Letters] The authors investigated the function of DMT1 isoform lacking the iron-response element in normal and malignant hematopoiesis.

Small-Molecule α-Lipoic Acid Targets ELK1 to Balance Human Neutrophil and Erythrocyte Differentiation

[Stem Cell Research & Therapy] In vitro culture of isolated CD34+, common myeloid progenitors, and CD34+ CD371 hematopoietic stem progenitor cells were performed to assay the differentiation potential of monocytes, neutrophils, and erythrocytes.

Regulation of Erythroid Differentiation via the HIF1α-NFIL3-PIM1 Signaling Axis under Hypoxia

[Antioxidants & Redox Signaling] Scientists studied the effect and mechanism of hypoxia on erythroid differentiation of K562 cells and observed the effect of hypoxia on early erythropoiesis of zebrafish.

GM-CSF Receptor Expression Determines Opposing Innate Memory Phenotypes at Different Stages of Myelopoiesis

[Blood] Researchers showed that GM-CSF programmmed myeloid committed progenitors to produce trained macrophages but programmed the upstream non-committed LKS+ progenitors to produce tolerized macrophages.

Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia

[Clinical Cancer Research] Investigators performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia cell samples derived from patients with AML.

Role of Reactive Oxygen Species in Myelodysplastic Syndromes

[Cellular & Molecular Biology Letters] The authors review the eminent role of reactive oxygen species in the hematological niche and their profound influence on the progress of myelodysplastic syndromes.

Innate Pharma Announces Advancement of Sanofi-Developed NK Cell Engager SAR443579/IPH6101 Progressing to Phase II for Blood Cancer Patients

[Innate Pharma] Innate Pharma SA announced that the first patient was dosed in the Phase II dose expansion part of the Sanofi-sponsored clinical trial of SAR443579 / IPH6101, evaluating SAR443579 as a monotherapy for the treatment of blood cancers with high unmet needs.

University of Sheffield Funding to Treat Blood Cancer Cells

[BBC] The University of Sheffield was given more than £2.5m funding to look into dormant cancer cells and develop new treatments for myeloma, a type of blood cancer.

Formation of Recurring Transient Ca2+-Based Intercellular Communities during Drosophila Hematopoiesis

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors revealed that tissue scale signaling regulation could arise from local gap-junction mediated cell–cell signaling through the spatiotemporal establishment of an intermediate-scale of transient multicellular communication communities over the course of tissue development.

Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1

[Jama Cardiology] Researchers determined whether clonal hematopoiesis of indeterminate potential was associated with atrial fibrillation, inflammatory and cardiac biomarkers, and cardiac structural changes.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.