Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Impaired Immunosuppressive Role of Myeloid-Derived Suppressor Cells in Acquired Aplastic Anemia

[Haematologica] Myeloid-derived suppressor cells (MDSCs) populations were evaluated in acquired aplastic anemia in which aberrant immune mechanisms contributed to bone marrow destruction.

CKS1 Inhibition Depletes Leukemic Stem Cells and Protects Healthy Hematopoietic Stem Cells in Acute Myeloid Leukemia

[Science Translational Medicine] Researchers studied the role of cyclin-dependent kinase regulatory subunit 1 (CKS1)–dependent protein degradation in primary human acute myeloid leukemia and healthy hematopoiesis xenograft models in vivo.

Successful Outcomes of Second Hematopoietic Stem Cell Transplantation for Graft Failure in Pediatric Patients with Severe Aplastic Anemia

[Scientific Reports] The authors analyzed 10 cases of second hematopoietic stem cell transplantation (HSCT) to treat severe aplastic anemia pediatric patients who suffered from graft failure and concluded that second haploidentical family donors HSCT is an effective treatment.

Decoding Lymphomyeloid Divergence and Immune Hyporesponsiveness in G-CSF-Primed Human Bone Marrow by Single-Cell RNA-Seq

[Cell Discovery] Through unbiased bioinformatics analysis, the authors showed the alterations in the transcriptional landscape of hematopoietic cells in granulocyte colony-stimulating factor (G-CSF)-primed bone marrow, and revealed that G-CSF-induced myeloid-biased differentiation initiated from the stage of lymphoid-primed multipotent progenitors.

Endothelial and Hematopoietic hPSCs Differentiation via a Hematoendothelial Progenitor

[Stem Cell Research & Therapy] Two hESCs and one hiPSC lines were differentiated into a hematoendothelial population, hPSC-ECs and blast colonies via CD144+-embryoid bodies.

Hematopoietic Differentiation Persists in Human iPSCs Defective in De Novo DNA Methylation

[BMC Biology] Researchers investigated if DNA methyltransferase 3A is essential for hematopoietic differentiation of human induced pluripotent stem cells (iPSCs).

Evaluating Immune Response and Metabolic Related Biomarkers Pre-Allogenic Hematopoietic Stem Cell Transplant in Acute Myeloid Leukemia

[PLoS One] Scientists identified patients with acute myeloid leukemia who underwent hematopoietic stem cell transplantation and had existing baseline plasma samples. Using those samples, they studied 65 blood based metabolomic and 61 immune/inflammatory related biomarkers, comparing patients with either long-term overall survival (OS) or short-term OS.

Hematopoiesis of Indeterminate Potential and Atherothrombotic Risk

[Thrombosis and Haemostasis] The authors explore the relationship between mutations in genes causing clonal hematopoiesis of indeterminate potential (CHIP) and atherothrombotic disorders, along with potential mechanisms of enhanced clonal outgrowth and potential therapies and strategies to slow CHIP progression.

Hyaluronic Acid–GPRC5C Signaling Promotes Dormancy in Hematopoietic Stem Cells

[Nature Cell Biology] Using single-cell RNA sequencing, scientists showed a continuous landscape of highly purified human bone marrow hematopoietic stem cells displaying varying degrees of dormancy.

European Medicines Agency Validates Bristol Myers Squibb’s Application for CAR T Cell Therapy Breyanzi in Relapsed or Refractory Large B-Cell Lymphoma after First-Line Therapy

[Bristol Myers Squibb] Bristol Myers Squibb announced that the European Medicines Agency has validated its type II variation application for extension of the indication for Breyanzi to treat adult patients with diffuse large B-cell lymphoma, high grade B-cell lymphoma, primary mediastinal large B-cell lymphoma and follicular lymphoma grade 3B, who are refractory or have relapsed within 12 months of initial therapy and are candidates for hematopoietic stem cell transplant.

PUM1 Mediates the Posttranscriptional Regulation of Human Fetal Hemoglobin

[Blood Advances] Researchers identified Pumilo-1 (PUM1), an RNA binding protein with no previously reported functions in erythropoiesis, as a direct post-transcriptional regulator of β-globin switching.

Lifelong Multilineage Contribution by Embryonic-Born Blood Progenitors

[Nature] Investigators used in situ barcoding and classical fate mapping to assess the developmental and clonal origins of adult blood in mice.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.

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