Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Histone H2A Deubiquitinases in the Transcriptional Programs of Development and Hematopoiesis: A Consolidated Analysis

[International Journal Of Biochemistry & Cell Biology] Researchers address H2A-DUB functions in epigenetic regulation of mammalian development and tissue maintenance by conducting a meta-analysis of 248 genomics datasets from 32 independent studies, focusing on the mouse model and covering ESCs, hematopoietic, and immune cell lineages.

TIM-3 Signaling Hijacks the Canonical Wnt/β-Catenin Pathway to Maintain Cancer Stemness in Acute Myeloid Leukemia

[Blood Advances] Scientists showed that the acute myeloid leukemia-specific autocrine loop constituted of T cell immunoglobulin mucin-3 (TIM-3) and its ligand, galectin-9, drove the canonical Wnt pathway to stimulate self-renewal and propagation of leukemic stem cells.

A Three-Gene Leukemic Stem Cell Signature Score Is Robustly Prognostic in Chronic Myelomonocytic Leukemia

[British Journal Of Haematology] Investigators described a concise three-gene expression signature, leukemic stem cell-3, as an independent and robust prognostic factor for leukemia-free and overall survival in chronic myelomonocytic leukemia.

The NFIA-ETO2 Fusion Blocks Erythroid Maturation and Induces Pure Erythroid Leukemia in Cooperation with Mutant TP53

[Blood] To address the role for the pathogenesis of the disease, investigators expressed the NFIA-ETO2 fusion in murine erythroblasts. They observed that NFIA-ETO2 significantly increased proliferation and impaired erythroid differentiation of murine erythroleuemia cells and of primary fetal liver-derived erythroblasts.

Targeting Pleckstrin-2-Akt Signaling Reduces Proliferation in Myeloproliferative Neoplasm Models

[Journal Of Clinical Investigation] Scientists identified first-in-class Plek2 inhibitors through an in silico high-throughput screening and cell-based assays followed by the synthesis of analogs. The Plek2-specific small molecule inhibitors showed potent inhibitory effects on cell proliferation.

Myeloid-Like B Cells Boost Emergency Myelopoiesis through IL-10 Production during Infection

[Journal Of Experimental Medicine] Researchers studied the impact of dasatinib in chronic myeloid leukemia patients and compared it with patients taking other TKI and healthy controls. They found that patients on dasatinib showed inhibition of both TCR and STAT5 signaling pathways, and reduced expression of T effector pro-inflammatory cytokines.

Differential Inhibition of T Cell Receptor and STAT5 Signaling Pathways Determines the Immunomodulatory Effects of Dasatinib in Chronic Phase Chronic Myeloid Leukemia

[Haematologica] Scientists studied the impact of dasatinib in chronic myeloid leukemia patients and compared with patients taking other tyrosine kinase inhibitors and healthy controls

Transgenic IDH2R172K and IDH2R140Q Zebrafish Models Recapitulated Features of Human Acute Myeloid Leukemia

[Oncogene] Investigators generated zebrafish models ofIDH2R172K and IDH2R140Q AML and reported their pathologic, functional, and transcriptomic features and therapeutic responses to target therapies.

Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD

[Hemasphere] The authors studied mice harboring a germline hypomorphic mutation of one Runx1 allele with a loss-of-function mutation in the other Runx1 allele, which displayed many hematologic characteristics found in human RUNX1-FPD patients.

Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D)

[American Journal of Nephrology] Investigators explored baseline characteristics and predictors of erythropoiesis-stimulating agents (ESA) hyporesponsiveness in a global randomized cardiovascular outcomes study comparing an investigational hypoxia-inducible factor prolyl hydroxylase inhibitor, daprodustat, with conventional (ESA) treatment.

The Effect of High-Dose Vitamin D Supplementation on Hepcidin-25 and Erythropoiesis in Patients with Chronic Kidney Disease

[Bmc Nephrology] Study subjects received either 8000 IU of cholecalciferol daily or a placebo for 12 weeks. Researchers evaluated the change in markers of hepcidin expression, erythropoiesis, and iron status from baseline to week 12 and compared the change between the groups.

Therapeutic Targeting of Tumour Myeloid Cells

[Nature Reviews Cancer] The authors discuss the first generation of myeloid modulators and highlight recent developments in modeling context-specific roles for different myeloid cell subtypes, which can ultimately inform how to drive more successful clinical trials.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.