Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Pathogenic GATA2 Genetic Variants Utilize an Obligate Enhancer Mechanism to Distort a Multilineage Differentiation Program

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists used a GATA2-deficient progenitor rescue system to analyze how genetic variation influences GATA2 functions.

KCTD5 Regulates Ikaros Degradation Induced by Chemotherapeutic Drug Etoposide in Hematological Cells

[Biological Chemistry] Researchers showed that chemotherapeutic drug etoposide reduced the protein levels of several isoforms of Ikaros including IK1, IK2 and IK4, but not IK6 or IK7, by accelerating protein degradation, in leukemic cells.

Iron Dysregulation and Inflammatory Stress Erythropoiesis Associates with Long-Term Outcome of COVID-19

[Nature Immunology] Researchers assessed 214 individuals infected with SARS-CoV-2, with varying disease severity, for one year from COVID-19 symptom onset to determine the early correlates of post-acute sequelae.

Leukemogenesis Occurs in a Microenvironment Enriched by Extracellular Microvesicles/Exosomes: Recent Discoveries and Questions to Be Answered

[Leukemia] Leukemogenesis occurs and progresses in extracellular microvesicles enriched microenvironments. The authors present a current point of view on this topic and review some selected most recent discoveries and papers.

BC Cancer Researchers Recognized With 2023 Canadian Cancer Society Challenge Grants

[BC Cancer Research] Congratulations to the BC Cancer researchers who are recipients of the 2023 Canadian Cancer Society Challenge Grants Competition. The grants provided through the competition support cancer research projects across the cancer continuum and across disciplines, with an ultimate goal of solving a problem in cancer that is meaningful to people affected by or at risk of cancer.

Runx1+ Vascular Smooth Muscle Cells Are Essential for Hematopoietic Stem and Progenitor Cell Development In Vivo

[Nature Communications] Researchers identified a subpopulation of NG2+Runx1+ perivascular cells that display a sclerotome-derived vascular smooth muscle cell transcriptomic profile.

Rituximab Added to Conditioning Regimen Significantly Improves Erythroid Engraftment in Major Incompatible ABO-Group Hematopoietic Stem Cell Transplantation

[Bone Marrow Transplantation] Investigators evaluated the efficacy of pre-transplant infusion of rituximab in patients with ABO-incompatibility in improving red blood cell engraftment after HSC transplantation, measured by time to reach transfusion independence.

Ferritin-Mediated Mitochondrial Iron Homeostasis Is Essential for the Survival of Hematopoietic Stem Cells and Leukemic Stem Cells

[Leukemia] Scientists reported that conditional deletion of ferritin heavy chain 1 in the hematopoietic system reduced the number and repopulation capacity of HSCs.

Rheological Properties of Blood in Multiple Myeloma Patients

[Scientific Reports] Researchers compared morphology and blood rheology parameters in patients with multiple myeloma and healthy individuals.

An Iron Rheostat Controls Hematopoietic Stem Cell Fate

[Cell Stem Cell] Investigators uncovered a role for transitory free cytoplasmic iron as a rheostat for adult stem cell fate control. They found that hematopoietic stem and multipotent progenitor cells harbored comparatively small amounts of free iron.

Immune-Onc Therapeutics Announces Orphan Drug Designation Granted by USFDA for IO-202 (Anti-LILRB4) for the Treatment of Chronic MyelomonocyticLeukemia (CMML)

[Immune-Onc Therapeutics, Inc.] Immune-Onc Therapeutics, Inc. announced that the US FDA has granted Orphan Drug Designation for IO-202 for the treatment of chronic myelomonocytic leukemia (CMML).

Targeting TNF/IL-17/MAPK Pathway in hE2A-PBX1 Leukemia: Effects of OUL35, KJ-Pyr-9, and CID44216842

[Haematologica] Investigators established a stable and heritable zebrafish line expressing human E2A-PBX1 (hE2APBX1) for high-throughput drug screening.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.