Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Targeting the Tumor Microenvironment for Treating Double Refractory Chronic Lymphocytic Leukemia

[Blood] The authors propose that the targeted modulation of the tumor microenvironment provides new therapeutic options for this group of "double refractory" patients.

CD8+ T Cell Differentiation and Dysfunction Inform Treatment Response in Acute Myeloid Leukemia

[Blood] Researchers leveraged a multimodal approach encompassing high-dimensional flow cytometry and single-cell transcriptomics and found that early memory CD8+ T cells were associated with therapy response and exhibit a bifurcation into two distinct terminal end states.

Mapping Variant Effects on Anti-Tumor Hallmarks of Primary Human T Cells With Base-Editing Screens

[Nature Biotechnology] Base editing of PIK3CD and PIK3R1 variants in T cells with an engineered T cell receptor specific to a melanoma epitope or in different generations of CD19 chimeric antigen receptor T cells demonstrated that discovered gain of function variants enhanced signaling, cytokine production and lysis of cognate melanoma and leukemia cell models, respectively.

HIV-1 RNA in Extracellular Vesicles Is Associated with Neurocognitive Outcomes

[Nature Communications] In a cross-sectional study of 84 HIV+ individuals of whom 43 were followed longitudinally, investigators found that HIV-1 RNAs are present in extracellular vesicles derived from cerebrospinal fluid and serum of all individuals.

Gastric Cancer Immune Microenvironment Score Predicts Neoadjuvant Chemotherapy Efficacy and Prognosis

[Journal of Pathology Clinical Research] Investigators verified the predictive value of tumor-infiltrating immune cells on the treatment response to neoadjuvant chemotherapy (NACT) and the prognosis of patients with advanced gastric cancer, and explored the impact of NACT on the tumor immune microenvironment.

PI3K/HSCB Axis Facilitates FOG1 Nuclear Translocation to Promote Erythropoiesis and Megakaryopoiesis

[eLife] Investigators identified heat shock cognate B as an indispensable protein for friend of GATA 1 (FOG1) nuclear translocation during erythropoiesis of K562 human erythroleukemia cells and cord-blood-derived human CD34+CD90+HSCs, as well as during megakaryopoiesis of the CD34+CD90+HSCs.

EVIDENCE Meta-Analysis: Evaluating Minimal Residual Disease as an Intermediate Clinical Endpoint for Multiple Myeloma

[Blood] This meta-analysis was based on the FDA guidance for considerations for a meta-analysis of minimal residual disease (MRD) as a clinical endpoint and evaluates MRD-negativity as an early endpoint reasonably likely to predict long-term clinical benefit.

RUNX1 C-terminal Mutations Impair Blood Cell Differentiation by Perturbing Specific Enhancer-Promoter Networks

[Blood Advances] Researchers characterized RUNX1 mutations outside of the runt homology domain. Their analysis of the patient data sets revealed that mutations within the C-terminus frequently occur in hematopoietic disorders.

BRG1/BRM Inhibitor Targets AML Stem Cells and Exerts Superior Preclinical Efficacy Combined with BET or Menin Inhibitor

[Blood] Investigators showed that FHD-286 induced differentiation and lethality in AML cells with MLL1 rearrangement or mutant NPM1, concomitantly causing perturbed chromatin accessibility and repression of c-Myc, PU.1, and CDK4/6.

The Glutaminase Inhibitor CB-839 Targets Metabolic Dependencies of JAK2-Mutant Hematopoiesis in MPN

[Blood Advances] Scientists showed that CB-839 strongly reduced the mitochondrial respiration rate of bone marrow cells from JAK2-V617F mutant mice, demonstrating a marked dependence of these cells on glutamine-derived ATP production.

SDHAF1 Confers Metabolic Resilience to Aging Hematopoietic Stem Cells by Promoting Mitochondrial ATP Production

[Cell Stem Cell] Researchers reported that HSCs acquired metabolic resilience that promoted cell survival. High-resolution real-time ATP analysis with glucose tracing and metabolic flux analysis revealed that old HSCs reprogrammed their metabolism to activate the pentose phosphate pathway.

Biological Relevance of Alternative Splicing in Hematologic Malignancies

[Molecular Medicine] Investigators provide an extensive overview of the biological relevance of aberrant isoforms of genes involved in the regulation of apoptosis, activation of key cellular signaling pathways, and cell metabolism.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.

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