A Latent Subset of Human Hematopoietic Stem Cells Resists Regenerative Stress to Preserve Stemness

Scientists identified distinct subsets of human long-term-HSCs that responded differently to regeneration-mediated stress: an immune checkpoint ligand CD112lo subset that exhibited a transient engraftment restraint before contributing to hematopoietic reconstitution and a primed CD112hi subset that responded rapidly.
[Nature Immunology]
Kaufmann, K. B., Zeng, A. G. X., Coyaud, E., Garcia-Prat, L., Papalexi, E., Murison, A., Laurent, E. M. N., Chan-Seng-Yue, M., Gan, O. I., Pan, K., McLeod, J., Boutzen, H., Zandi, S., Takayanagi, S., Satija, R., Raught, B., Xie, S. Z., & Dick, J. E. (2021). A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-021-00925-1 Cite
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C/EBPβ Is a MYB- and p300-Cooperating Pro-leukemogenic Factor and Promising Drug Target in Acute Myeloid Leukemia

Scientists characterized a group of natural sesquiterpene lactones, previously shown to suppress MYB activity, for their potential to decrease AML cell proliferation.
[Oncogene]
Yusenko, M. V., Trentmann, A., Casolari, D. A., Abdel Ghani, L., Lenz, M., Horn, M., Dörner, W., Klempnauer, S., Mootz, H. D., Arteaga, M. F., Mikesch, J.-H., Andrea, R. J. D., Gonda, T. J., Müller-Tidow, C., Schmidt, T. J., & Klempnauer, K.-H. (2021). C/EBPβ is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01800-x Cite
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miR-204-5p and Platelet Function Regulation: Insight into a Mechanism Mediated by CDC42 and GPIIbIIIa

Human hematopoietic stem cells were differentiated into megakaryocytes, enabling the transfection of miR-204-5p and the recovery of subsequent platelet-like structures.
[Thrombosis and Haemostasis]
Garcia, A., Dunoyer-Geindre, S., Nolli, S., Strassel, C., Reny, J.-L., & Fontana, P. (2021). miR-204-5p and platelet function regulation: insight into a mechanism mediated by CDC42 and GPIIbIIIa. Thrombosis and Haemostasis, 0(AAM). https://doi.org/10.1055/a-1497-9649 Cite
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YTHDF2 Is a Potential Target of AML1/ETO-HIF1α Loop-Mediated Cell Proliferation in t(8; 21) AML

Scientists showed that YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) was highly expressed in t(8;21) acute myeloid leukemia (AML) patients and associated with a higher risk of relapse and inferior relapse-free survival. Knockdown of YTHDF2 in leukemia cells caused an impaired cell proliferation rate in vitro and in mice.
[Oncogene]
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Hematopoietic Stem Cells Retain Functional Potential and Molecular Identity in Hibernation Cultures

The authors describe a powerful seven day HSC hibernation culture system that maintained HSCs as single cells in the absence of a physical niche.
[Stem Cell Reports]
Oedekoven, C. A., Belmonte, M., Bode, D., Hamey, F. K., Shepherd, M. S., Che, J. L. C., Boyd, G., McDonald, C., Belluschi, S., Diamanti, E., Bastos, H. P., Bridge, K. S., Göttgens, B., Laurenti, E., & Kent, D. G. (2021). Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.04.002 Cite
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A 3D iPSC-Differentiation Model Identifies Interleukin-3 as a Regulator of Early Human Hematopoietic Specification

Researchers used induced pluripotent stem cell technology and established a 3D, organoid-like differentiation system maintaining the structural cellular integrity to evaluate the effect of cytokines on embryonic hematopoietic development.
[Haematologica]
Ackermann, M., Haake, K., Kempf, H., Kaschutnig, P., Weiss, A.-C., Nguyen, A. H. H., Abeln, M., Merkert, S., Kühnel, M. P., Hartmann, D., Jonigk, D., Thum, T., Kispert, A., Milsom, M. D., & Lachmann, N. (2021). A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification. Haematologica, 106(5), 1354–1367. https://doi.org/10.3324/haematol.2019.228064 Cite
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T-Cell-Based Immunotherapy of Acute Myeloid Leukemia: Current Concepts and Future Developments

The stellar successes of immunotherapies that harness the power of T cells to treat solid tumors and an improved understanding of the immune systems of patients with hematologic malignancies have led to major efforts to develop immunotherapies for the treatment of patients with AML.
[Leukemia]
Daver, N., Alotaibi, A. S., Bücklein, V., & Subklewe, M. (2021). T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments. Leukemia, 1–21. https://doi.org/10.1038/s41375-021-01253-x Cite
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Platelets and Extracellular Vesicles and Their Cross-Talk with Cancer

The authors summarize the emerging understanding of the complex roles of platelet-derived microvesicles in the development and progression of cancer and cancer co-morbidities.
[Blood]
Lazar, S., & Goldfinger, L. E. (2021). Platelets and extracellular vesicles and their cross-talk with cancer. Blood, blood.2019004119. https://doi.org/10.1182/blood.2019004119 Cite
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Role of Ex Vivo Expanded Mesenchymal Stromal Cells in Determining Hematopoietic Stem Cell Transplantation Outcome

Investigators explore the several mechanisms through which MSCs impact on the supportive activity of the bone marrow niche and regulate hematopoietic stem and progenitor cell homeostasis.
[Frontiers in Cell and Developmental Biology]
Crippa, S., Santi, L., Berti, M., De Ponti, G., & Bernardo, M. E. (2021). Role of ex vivo Expanded Mesenchymal Stromal Cells in Determining Hematopoietic Stem Cell Transplantation Outcome. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.663316 Cite
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3D Bioprinting Allows the Establishment of Long-Term 3D Culture Model for Chronic Lymphocytic Leukemia Cells

The authors exploited for the first time 3D bioprinting to advance in vitro models for chronic lymphocytic leukemia (CLL). They monitored over time CLL cells viability, phenotype and gene expression, thus establishing a reproducible long-term 3D culture model for leukemia.
[Frontiers in Immunology]
Sbrana, F. V., Pinos, R., Barbaglio, F., Ribezzi, D., Scagnoli, F., Scarfò, L., Redwan, I. N., Martinez, H., Farè, S., Ghia, P., & Scielzo, C. (2021). 3D Bioprinting Allows the Establishment of Long-Term 3D Culture Model for Chronic Lymphocytic Leukemia Cells. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.639572 Cite
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Prognostic Factors in Salvage Transplantation for Graft Failure following Allogeneic Hematopoietic Stem Cell Transplantation

Scientists developed a comprehensive prognostic scoring system consisting of patient and comorbidity factors with 470 patients as a training cohort out of 940; these patients underwent salvage stem cell transplantation for graft failure.
[Bone Marrow Transplantation]
Harada, K., Kimura, S., Fuji, S., Najima, Y., Yakushijin, K., Uchida, N., Onizuka, M., Ikegame, K., Yano, S., Shingai, N., Matsuoka, K., Onishi, Y., Sawa, M., Takada, S., Kawakita, T., Fukuda, T., Kanda, J., Atsuta, Y., & Nakasone, H. (2021). Prognostic factors in salvage transplantation for graft failure following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation, 1–11. https://doi.org/10.1038/s41409-021-01310-0 Cite
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