Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Athernal Bio Secures Innovate UK Grant to Advance Cancer Interception in High-Risk Leukaemia
[Athernal Bio (BioSpace)] Athernal Bio announced it has been awarded a grant of nearly £700,000 through Innovate UK’s Growth Catalyst - Investor Partnerships program. The funding will accelerate the development of Athernal’s immunotherapy program, designed to intercept the earliest stages of AML.
Type 1 Interferon Perturbates Clonal Competition by Reshaping Human Blood Development
[Nature Genetics] Researchers studied HSCs, progenitors, and immune cells from patients with myeloproliferative neoplasms at baseline and following IFNα treatment. They deployed single-cell multiomics methods that distinguish the IFNα effects on mutated stem cells from the admixed wild-type HSC.
An Active TCA Cycle State Defines a High-Risk Acute Lymphoblastic Leukemia Subtype
[NPJ Precision Oncology] By constructing a single-cell transcriptional metabolic landscape, investigators identified the tricarboxylic acid cycle as the dominant source of metabolic heterogeneity in leukemic cells, enabling their stratification into three distinct states.
Bone Marrow-Inspired DLL1-Presenting Microparticles Enhance Asymmetric Division and Maintenance of Mouse Hematopoietic Stem and Progenitor Cells
[Stem Cell Reports] Through cell-cell communication analysis of bone marrow single-cell sequencing data, researchers identified the Notch ligand Delta-like protein 1 (DLL1) as a potential regulator in hematopoietic stem and progenitor cell asymmetric division.
Rare Hematopoietic Stem Cells Resilient to Infection-Induced Stress Sense Yet Withstand Inflammation
[Blood] Using combined functional, single-cell transcriptomics and phenotypic analyses, scientists uncovered that BiotinHi HSCs remain highly functional despite expressing strong interferon response signatures.
The Stress-Sensing MARCH5 Axis Governs Blood Cancer Apoptotic Resilience via Tractable Protein-Protein Interactions
[Blood] The authors showed that MARCH5 cooperates with UBE2J2 and MFN2, forming a stress-sensing complex at mitochondria-ER contact sites that restrains apoptosis in response to diverse organellar damage signals. Loss of MARCH5 sensitizes diverse blood cancer cell lines to BCL-2 and BCL-XL inhibition.
The V Foundation for Cancer Research Awards $1.8 Million in Grants to Children’s Hospital of Philadelphia Researchers
[CHOP] Children’s Hospital of Philadelphia (CHOP) announced nearly $2 million in funding from the V Foundation for Cancer Research. The grants were awarded to two research leaders advancing innovative approaches to detecting and treating cancer in children.
Targeting CD38 with Bispecific Antibody XmAb 18968 in Patients with Relapsed/Refractory Acute Myeloid Leukemia and T Cell Acute Lymphoblastic Leukemia
[Leukemia] In this Phase I multicenter clinical trial, researchers evaluated the outcomes of XmAb18968 in adults with relapsed/refractory AML and T cell acute lymphoblastic leukemia.
GAA Engineered to Improve Cellular Uptake Enhances Correction in a Preclinical Hematopoietic Stem Cell Gene Therapy Model of Pompe Disease
[Molecular Therapy] Scientists evaluated the potential of HSC gene therapy to correct acid alpha-glucosidase (GAA) deficiency in a murine model of Pompe disease. To improve lysosomal delivery, they engineered a novel GAA transgene by adding a peptide tag targeting the insulin-like growth factor 2 binding domain.
Resistance Mechanisms and Therapeutic Strategies after Menin Inhibitor Failure in Acute Myeloid Leukemia
[International Immunopharmacology] The authors synthesize evidence on the biological and clinical landscape of menin inhibitor resistance in AML. They address on-target MEN1 mutations, off-target clonal evolution, epigenetic and transcriptional reprogramming, and microenvironment-mediated adaptive signals.
Integration of an Anellovirus Genome in the SKNO-1 Acute Myeloid Leukemia Cell Line
[Microbiology Spectrum] Researchers identified a stably integrated and transcriptionally active anellovirus genome in anAML cell line, providing a unique model to study viral persistence in hematopoietic cells.
CD55 Promotes Hematopoietic Stem and Progenitor Cell Survival in a Mouse Model of Immune-Mediated Aplastic Anaemia
[Blood Advances] Scientists showed that CD55 protects hematopoietic stem and progenitor cells from complement-mediated damage in aplastic anemia, highlighting complement inhibition as a potential therapeutic strategy
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
