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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
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Dr. Josep Maria Ribera Recognised with EHA Clinical Excellence Award
[Josep Carreras Leukemia Research Institute] Dr. Josep Maria Ribera, head of the Acute Lymphoblastic Leukaemia laboratory at the Josep Carreras Leukemia Research Institute, has been awarded the prestigious EHA Clinical Excellence Award 2026.
Human Hematopoietic Stem Cells Remember Inflammatory Stress
[Nature] Investigators developed xenograft inflammation–recovery models and performed single-cell multiomics on xenografted human hematopoietic stem cells.
Sphingosine-1-Phosphate Receptor Modulators Resensitize FLT3-ITD Acute Myeloid Leukemia Cells with NRAS Mutations to FLT3 Inhibitors
[Leukemia] Scientists studied sphingosine-1-phosphate and FLT3 co-targeting to overcome FLT3 inhibitor resistance in NRAS-mutated FLT3-ITD AML cells.
A Novel CD7-Directed Antibody-Drug Conjugate Targeting BCL-XL with Potent Anti-Leukemic Activity in T-Cell Acute Lymphoblastic Leukemia
[Leukemia] Researchers reported the design of a novel anti-hCD7 mAb-based antibody-drug conjugate carrying a BCL-XL-selective inhibitor that circumvents this significant limitation.
Reversible Loss of Hematopoietic Stem Cells Transplant Potency by Chronic Salmonella Infection
[Cell Reports] Scientists showed that chronic Salmonella infection significantly impair stem and progenitor cells of the bone marrow. As early as 14 days post-infection, the transplantation potency of HSC is depleted.
Prognostic Impact of Variant Allele Frequency in Intensively Treated Patients with NPM1-Mutated AML: A PETHEMA Study
[Blood] Researchers analyzed 688 intensively treated NPM1-mutated AML integrating variant allele frequency, mutation order, and clonal architecture inferred by PyClone and ClonEvol.
Therapeutic Outcomes in VEXAS Syndrome: A Multicenter Comparative Cohort of Allogeneic Hematopoietic Stem Cell Transplantation and Hypomethylating Agents
[American Journal of Hematology] Investigators conducted a multicenter, retrospective analysis of 66 patients diagnosed with VEXAS syndrome treated with hypomethylating agents or allogeneic HSC transplantation.
Discovery of BEND4 As a Novel Single-Gene Prognostic Marker and Therapeutic Target for Adverse AML
[npj Precision Oncology] The authors used transcriptome analyses of primary AML cohorts and identified BEN domain-containing protein 4 (BEND4) as significantly overexpressed in adverse cytogenetic risk.
Evolving Landscape of Targeted Immunotherapeutic Interventions and CAR-T Therapy for Acute Myeloid Leukemia
[npj Precision Oncology] Scientists provide a comprehensive overview of the evolving landscapes of immunotherapeutic strategies, challenges, and breakthroughs in tackling AML.
Targeting ZMIZ1 Induces Differentiation in Acute Myeloid Leukemia via Chromatin Remodeling
[Signal Transduction and Targeted Therapy] Researchers identified Zinc finger MIZ domain-containing protein 1 (ZMIZ1) as a previously unrecognized transcriptional co-regulator that enforces differentiation blockade in AML from a targeted CRISPR-Cas9 screen.
A Kinetics-Based Model of Haematopoiesis Reveals Extrinsic Regulation of Skewed Lineage Output from Stem Cells
[Nature Cell Biology] By performing single-cell transplantations of over 1,000 highly purified murine long-term HSCs combined with in-depth phenotyping of their clonal progeny, scientists defined kinetics-based reconstitution parameters which aligned HSCs into a single hierarchical trajectory reflective of functional potency.
Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome
[Blood] To understand the connection between chromatin accessibility and GATA1, investigators comprehensively studied erythropoiesis in Stag2∆ mice.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
