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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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CDK1-Mediated Phosphorylation of APE1 Drives Synthetic Lethality, p53-Dependent Metastasis, and Immune Sensitization in NSCLC
[Cell Death & Disease] Researchers identified a previously unrecognized regulatory link between cyclin-dependent kinase 1 (CDK1) and apurinic/apyrimidinic endonuclease 1 (APE1) in NSCLC.
Triglyceride Enhancs NSCLC Metastasis via Lipid β-oxidation by RhoA-Driven Cytoskeletal Remodeling in ECM-Constrained Microenvironments
[British Journal of Cancer] Scientists reported that elevated serum triglycerides promotes NSCLC metastasis through a lipid β-oxidation–RhoA–cytoskeletal axis. They suggest that targeting lipid catabolism and cytoskeletal dynamics may represent a therapeutic strategy for hypertriglyceridemia-associated NSCLC.
A Novel Bispecific Antibody Targeting Frizzled7/PD-L1 Overcomes NSCLC Resistance to Atezolizumab by Reprogramming Tumor Microenvironment
[NPJ Precision Oncology] Investigators elucidated the role of Frizzled7 in shaping the immunosuppressive tumor microenvironment and develop a novel bispecific antibody that co-targets Fzd7 and programmed cell death ligand 1.
The Telomeric DNA Damage Response As a Therapeutic Target in Idiopathic Pulmonary Fibrosis
[EMBO Molecular Medicine] Researchers identified telomeric DNA damage signaling as a driver of idiopathic pulmonary fibrosis, with targeted inhibition reversing key molecular and fibrotic features of disease.
Targeting the S100A2-RAGE Pathway Restores AT2 Cell Identity and Mitigates Lung Fibrosis
[American Journal of Respiratory Cell and Molecular Biology] Scientists indicated that S100A2 is a key driver of epithelial dysfunction in lung fibrosis, promoting loss of alveolar type 2 epithelial (AT2) identity, aberrant basal fate acquisition, and persistent epithelial injury.
The Ferroptosis Inhibitor NUPR1 Coordinates the Mitochondrial Response to Oxidative Stress and Cell Metabolism during COPD Pathogenesis in the Lung
[American Journal of Physiology-Lung Cellular and Molecular Physiology] Investigators demonstrated that nuclear protein 1 (NUPR1) inhibition exacerbates iron accumulation, enhances lipid peroxidation, impairs mitochondrial function, disrupts cellular metabolism, and increases oxidative stress in lung epithelial cells.
USP22 Enhances Mitochondrial Biogenesis via Stabilizing MYBBP1A in Non-Small Cell Lung Cancer
[Cancer Letters] Researchers reported the novel finding that ubiquitin-specific protease 22 (USP22), a key regulator of protein ubiquitination and transcriptional activity, regulates mitochondrial protein expression, and oxidative phosphorylation.
LINC00673 Upregulation and rs9914618 Polymorphism: Associations with Risk and Prognosis of Lung Squamous Cell Carcinoma
[Expert Review of Molecular Diagnostics] The authors identified LINC00673 upregulation and the rs9914618 variant as potential biomarkers of lung squamous cell carcinoma risk and prognosis.
TRDMT1 Slows Lung Cancer Growth by Stabilizing TFRC mRNA and Triggering Ferroptosis Cell Death
[Journal of Biological Chemistry] Investigators identified TRDMT1 (DNMT2), an m5C methyltransferase, as a tumor suppressor in LUAD. It was found that TRDMT1 expression is significantly lower in LUAD tissues, and this reduction is associated with poor prognosis in patients.
TXNDC15 Suppresses Lung Adenocarcinoma Progression by Inducing NEK4-Dependent G2/M Entry Blockade
[Biochemical and Biophysical Research Communications] Scientists showed that Thioredoxin domain-containing (TXNDC)15 is downregulated in LUAD and predicts better survival. Functional assays revealed that TXNDC15 suppresses proliferation by inducing G2/M phase arrest.
Collaborative Functionality Between Three Types of Inflammation in Idiopathic Pulmonary Fibrosis
[Nature Immunology] The authors highlight how distinct inflammatory programs work together within the fibrotic lung niche to drive the progression of idiopathic pulmonary fibrosis.
Dysplastic Basal-Like Cells in Alveolar Repair and Regeneration
[Seminars in Cell & Developmental Biology] Researchers highlight how dysplastic basal-like cells emerge after severe lung injury, linking abnormal alveolar repair to failed regeneration and chronic lung disease progression.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
