Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer

[Cancer Research] Two angiogenic factors, OPN and SERPINE1, were decreased in Cd248LacZ/LacZ pericytes, and supplementation with both factors rescued their proliferation and endothelial cell tube formation-promoting ability.

Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents

[Communications Biology] The authors described the cellular complexity of human alveolar and tracheobronchial air liquid interface tissue models during SARS-CoV-2 and influenza A virus infections.

Methylene Blue, Mycophenolic Acid, Posaconazole, and Niclosamide Inhibit SARS-CoV-2 Omicron Variant BA.1 Infection of Human Airway Epithelial Organoids

[Current Opinion in Microbiology] Investigators demonstrated the susceptibility of the Omicron variant BA.1 to four repurposable drugs, Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide in post-exposure treatments of primary human airway cell cultures.

Mount Sinai Awarded Three-Year Grant to Explore Therapeutic Approaches to KRAS Mutant Lung Tumors

[Imaging Technology News] Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.

The circRERE/miR-144-3p/TLR2/MMP9 Signaling Axis in COPD Pulmonary Monocytes Promotes the EMT of Pulmonary Epithelial Cells

[Biochemical and Biophysical Research Communications] Using a co-culture system, scientists identified that the TLR2/MMP9 axis in pulmonary monocytes promoted the epithelial mesenchymal transition (EMT) of pulmonary epithelial cells.

Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma

[American Journal of Respiratory Cell and Molecular Biology] In cultured human bronchial epithelial cells, cadherin-26 knockdown inhibited IL-13 induced IL-4Rα and IL-13Rα1 upregulation and suppressed downstream Jak1 and Stat6 phosphorylation.

Copper(II) Cation and Bathophenanthroline Coordination Enhance Therapeutic Effects of Naringenin Against Lung Tumor Cells

[Biometals] Scientists investigated the effects of copper (Cu) (II), naringenin, binary Cu(II)-naringenin complex, and the Cu(II)-naringenin containing bathophenanthroline as an auxiliary ligand on adenocarcinoma human alveolar basal epithelial cells (A549 cells) that were used as models for the study of drug therapies against lung cancer.

Club Cells Employ Regeneration Mechanisms During Lung Tumorigenesis

[Nature Communications] Researchers employed lineage-tracing mouse models to investigate the cell of origin of Eml4-Alk lung adenocarcinoma, and showed that Club and alveolar type 2 cells gave rise to tumors.

Decreased Humoral Immune Response in the Bronchi of Rapid Decliners With Chronic Obstructive Pulmonary Disease

[Respiratory Research] Scientists determined the expression of markers of inflammation in COPD patients with rapid functional decline in comparison to slow or no decliners.

Down-Regulated m6A Reader FTO Destabilizes PHF1 That Triggers Enhanced Stemness Capacity and Tumor Progression in Lung Adenocarcinoma

[Cell Death Discovery] Investigators found that human plant homeodomain finger protein 1 (PHF1) was down-regulated in lung adenocarcinoma samples and low PHF1 expressions correlated with unfavorable clinical characteristics.

βIII-Tubulin Suppression Enhances the Activity of Amuvatinib To Inhibit Cell Proliferation in C-Met Positive Non-Small Cell Lung Cancer Cells

[Cancer Medicine] Researchers showed that activity of the multi-kinase inhibitor Amuvatinib was enhanced by βIII-tubulin suppression in independent NSCLC cell lines.

Identification of Exosomal circRNA CD226 as a Potent Driver of Non-Small Cell Lung Cancer Through miR-1224-3p/High Mobility Group At-Hook 2 Axis

[Anti-Cancer Drugs] Researchers unraveled the precise function of circRNA CD226 in NSCLC pathogenesis.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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