An RFC4/Notch1 Signaling Feedback Loop Promotes NSCLC Metastasis and Stemness

To understand how Notch signaling was overactivated to couple tumor metastasis and self-renewal in NSCLC cells, researchers showed that RFC4, directly bound to the Notch1 intracellular domain (NICD1) to competitively abrogate CDK8/FBXW7-mediated degradation of NICD1.
[Nature Communications]
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First Time in Thailand – Chula Successfully Uses Stem-Cell Transplantation to Treat Systemic Sclerosis Patients with Pulmonary Fibrosis

The faculty of medicine at Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society , in collaboration with the Departments of Hematology, Pulmonary and Critical Care Medicine, and Infectious diseases, held a press conference on “Thailand’s first successful treatment of systemic sclerosis patients with pulmonary fibrosis by stem cell transplantation“.
[Chulalongkorn University (Newswise, Inc.)]
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Lung Cancer Organoids Analyzed on Microwell Arrays Predict Drug Responses of Patients within a Week

The authors adapted a mechanical sample processing method to generate lung cancer organoids from surgically resected and biopsy tumor tissues.
[Nature Communications]
Hu, Y., Sui, X., Song, F., Li, Y., Li, K., Chen, Z., Yang, F., Chen, X., Zhang, Y., Wang, X., Liu, Q., Li, C., Zou, B., Chen, X., Wang, J., & Liu, P. (2021). Lung cancer organoids analyzed on microwell arrays predict drug responses of patients within a week. Nature Communications, 12(1), 2581. https://doi.org/10.1038/s41467-021-22676-1 Cite
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Fibroblast CEBPD/SDF4 Axis in Response to Chemotherapy-Induced Angiogenesis through CXCR4

The authors found that cisplatin and 5-fluorouracil could induce fibroblast differentiation toward myofibroblasts via CCAAT/enhancer-binding protein delta and consequently promote proliferation, migration, and in vitro tube formation of vascular endothelial cells and angiogenesis in vivo.
[Cell Death & Discovery]
Chi, J.-Y., Hsiao, Y.-W., Liu, H.-L., Fan, X.-J., Wan, X.-B., Liu, T.-L., Hung, S.-J., Chen, Y.-T., Liang, H.-Y., & Wang, J.-M. (2021). Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4. Cell Death Discovery, 7(1), 1–16. https://doi.org/10.1038/s41420-021-00478-0 Cite
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EGFR-ERK Induced Activation of GRHL1 Promotes Cell Cycle Progression by Up-Regulating Cell Cycle Related Genes in Lung Cancer

Scientists found that GRHL1 was upregulated in non-small cell lung cancer and correlated with poor survival of patients.
[Cell Death & Disease]
He, Y., Gan, M., Wang, Y., Huang, T., Wang, J., Han, T., & Yu, B. (2021). EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer. Cell Death & Disease, 12(5), 1–13. https://doi.org/10.1038/s41419-021-03721-9 Cite
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Potential Role for EZH2 in Promotion of Asthma through Suppression of miR-34b Transcription by Inhibition of FOXO3

Researchers investigated the molecular mechanism of enhancer of zeste homolog 2 (EZH2) in the development of asthma.
[Laboratory Investigation]
Liu, B., Sun, H., Wang, J., Liu, H., & Zhao, C. (2021). Potential role for EZH2 in promotion of asthma through suppression of miR-34b transcription by inhibition of FOXO3. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-021-00585-7 Cite
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Differential Chromatin Binding of the Lung Lineage Transcription Factor NKX2-1 Resolves Opposing Murine Alveolar Cell Fates In Vivo

Scientists reported that the cell-type-specific function of NKX2-1 was attributed to its differential chromatin binding that was acquired or retained during development in coordination with partner transcriptional factors.
[Nature Communications]
Little, D. R., Lynch, A. M., Yan, Y., Akiyama, H., Kimura, S., & Chen, J. (2021). Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo. Nature Communications, 12(1), 2509. https://doi.org/10.1038/s41467-021-22817-6 Cite
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Reversed-Engineered Human Alveolar Lung-on-a-Chip Model

[Proceedings of the National Academy of Sciences of the United States of America]
Huang, D., Liu, T., Liao, J., Maharjan, S., Xie, X., Pérez, M., Anaya, I., Wang, S., Mayer, A. T., Kang, Z., Kong, W., Mainardi, V. L., Garciamendez-Mijares, C. E., Martínez, G. G., Moretti, M., Zhang, W., Gu, Z., Ghaemmaghami, A. M., & Zhang, Y. S. (2021). Reversed-engineered human alveolar lung-on-a-chip model. Proceedings of the National Academy of Sciences, 118(19). https://doi.org/10.1073/pnas.2016146118 Cite
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Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non-small Cell Lung Cancer

Researchers investigated the acquired resistance mechanism of epidermal growth factor receptor kinase domain duplication (EGFR-KDD) against EGFR-tyrosine kinase inhibitors (EGFR TKIs).
[Cancer Research and Treatment]
Lee, C., Kim, M., Kim, D.-W., Kim, T. M., Kim, S., Im, S.-W., Jeon, Y. K., Keam, B., Ku, J.-L., & Heo, D. S. (2021). Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non-Small Cell Lung Cancer. Cancer Research and Treatment. https://doi.org/.0.0.0 Cite
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Lung Carcinoid Tumors with Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) Exhibit Pejorative Pathological Features

[Lung Cancer]
Prieto, M., Chassagnon, G., Lupo, A., Charpentier, M.-C., Cabanne, E., Groussin, L., Wislez, M., Alifano, M., & Fournel, L. (2021). Lung carcinoid tumors with Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) exhibit pejorative pathological features. Lung Cancer, 156, 117–121. https://doi.org/10.1016/j.lungcan.2021.04.024 Cite
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Single-Cell Profiling of Tumor Heterogeneity and the Microenvironment in Advanced Non-small Cell Lung Cancer

we analyze 42 tissue biopsy samples from stage III/IV non-small cell lung cancer (NSCLC) patients by single cell RNA sequencing and present the large scale, single cell resolution profiles of advanced NSCLCs.
[Nature Communications]
Wu, F., Fan, J., He, Y., Xiong, A., Yu, J., Li, Y., Zhang, Y., Zhao, W., Zhou, F., Li, W., Zhang, J., Zhang, X., Qiao, M., Gao, G., Chen, S., Chen, X., Li, X., Hou, L., Wu, C., … Zhou, C. (2021). Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nature Communications, 12(1), 2540. https://doi.org/10.1038/s41467-021-22801-0 Cite
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