Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

Dnah9 Mutant Mice and Organoid Models Recapitulate the Clinical Features of Patients with PCD and Provide an Excellent Platform for Drug Screening

[Cell Death & Disease] Investigators constructed an airway organoid of Dnah9 knock-down mice and discovered that it could mimic the key features of the primary cilia dyskinesia phenotypes.

A Bipotential Organoid Model of Respiratory Epithelium Recapitulates High Infectivity of SARS-CoV-2 Omicron Variant

[Cell Discovery] Investigators defined a ‘distal’ differentiation approach to generate alveolar organoids from the same source for the derivation of airway organoids.

Smurf2 Inhibition Enhances Chemotherapy and Radiation Sensitivity in Non-Small-Cell Lung Cancer

[Scientific Reports] To identify novel genes that modulate the response to platinum-based therapy, scientists performed a genome-wide high-throughput ribonucleic acid interference screen via transfection of human lung cancer cells with a viral short hairpin RNA library.

MERTK Activation Drives Osimertinib Resistance in EGFR-Mutant Non-Small Cell Lung Cancer

[Journal of Clinical Investigation] Treatment with MRX-2843, a first-in-class MERTK kinase inhibitor, re-sensitized GAS6-treated NSCLC cells to osimertinib.

Vascular Endothelial Growth Factor Receptor 2 Expression and Immunotherapy Efficacy in Non-Small Cell Lung Cancer

[Cancer Science] Patients with advanced non-small cell lung cancer were treated with immune-checkpoint inhibitors. Scientists analyzed immune and tumor cell staining separately in order to determine their correlation with the objective response rate, progression-free survival and overall survival in patients receiving immune-checkpoint inhibitors.

HIF-1α Mediates Arsenic-Induced Metabolic Reprogramming in Lung Bronchial Epithelial Cells

[Biological Trace Element Research] The authors confirmed the role of HIF-1α in arsenic-induced mitochondrial damage, the effect of HIF-1α siRNA on sodium arsenite-induced glycolysis in human bronchial epithelial cells was examined.

CFTR Reduces the Proliferation of Lung Adenocarcinoma and Is a Strong Predictor of Survival in Both Smokers and Non-Smokers

[Journal of Cancer Research and Clinical Oncology] Scientists systematically analyzed expression signatures of all 48 human ABC transporters in samples from 8562 patients across 14 different cancer types. The association between CFTR (ABCC7) expression and outcomes was analyzed experimentally using knock-downs and pharmacological CFTR stimulation.

An mTOR and DNA-PK Dual Inhibitor CC-115 Hinders Non-Small Cell Lung Cancer Cell Growth

[Cell Death Discovery] Scientists evaluated the activity of CC-115, a potent DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) dual blocker, in different human non-small cell lung cancer cells.

FDA Denies Authorization to Market JUUL Products

[FDA] The US FDA issued marketing denial order to JUUL Labs Inc. for all of their products currently marketed in the United States.

Cullinan Oncology and Taiho Pharmaceutical Complete Agreement for Strategic Collaboration to Jointly Develop and Commercialize CLN-081/TAS6417

[Cullinan Oncology, Inc.] Cullinan Oncology, Inc. a biopharmaceutical company focused on developing a diversified pipeline of targeted therapies for patients with cancer, announced the completion of its agreement with Taiho Pharmaceutical Co., Ltd. signed in May 2022.

BRAF/MEK Inhibition in NSCLC: Mechanisms of Resistance and How to Overcome It

[Clinical and Translational Oncology] Investigators discuss inhibition of BRAF and its downstream effector MEK which constitutes a therapeutic strategy for a subset of patients with NSCLC and is associated with clinical benefit.

Human Lungs Show Limited Permissiveness for SARS-CoV-2 Due to Scarce ACE2 Levels but Virus-Induced Expansion of Inflammatory Macrophages

[European Respiratory Journal] Spectral microscopy, single-cell/-nucleus RNA sequencing or ACE2 ‘gain-of-function’ experiments were applied on infected human lung explants and adult stem cell-derived human lung organoids to correlate ACE2 and related host factors with SARS-CoV-2 tropism, propagation, virulence and immune activation.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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