The authors investigated the dynamic toxicities of naphthalene-derived secondary organic aerosol in a human bronchial epithelial cell line and identified the chemical components responsible for toxicities.
[Proceedings of the National Academy of Sciences of the United States of America]
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Han, J., Wang, S., Yeung, K., Yang, D., Gu, W., Ma, Z., Sun, J., Wang, X., Chow, C.-W., Chan, A. W. H., & Peng, H. (2020). Proteome-wide effects of naphthalene-derived secondary organic aerosol in BEAS-2B cells are caused by short-lived unsaturated carbonyls. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2001378117 Cite
Vertex Pharmaceuticals Incorporated announced the FDA approved KALYDECO® for use in children with cystic fibrosis ages four months to less than six months old who have at least one mutation in their cystic fibrosis transmembrane conductance regulator gene that is responsive to KALYDECO based on clinical and/or in vitro assay data.
[Vertex Pharmaceuticals Incorporated]
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Investigators showed abnormal upregulation of tumor protein p63 (TP63) and downregulation of miR-184 in idiopathic pulmonary fibrosis. Transforming growth factor beta 1 stimulation of BEAS-2B and A549 cell lines significantly increased the protein levels of Tp63, alpha-smooth muscle actin, and vimentin, but decreased EpCAM protein levels, and promoted viability of both BEAS-2B and A549 cell lines.
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Researchers determined that microRNA-3613-5p plays a crucial role in RELA-mediated post-transcriptional regulation of lung adenocarcinoma cell proliferation.
[Molecular Therapy-Nucleic Acids]
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He, T., Shen, H., Wang, S., Wang, Y., He, Z., Zhu, L., Du, X., Wang, D., Li, J., Zhong, S., Huang, W., & Yang, H. (2020). MicroRNA-3613-5p promotes lung adenocarcinoma cell proliferation through a RELA and AKT/MAPK positive feedback loop. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.024 Cite
Single-cell transcriptome analysis identified brain-derived neurotrophic factor as a STAT3 target gene with newly accessible chromatin in a unique population of regenerating AT2 cells.
[Nature Cell Biology]
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Paris, A. J., Hayer, K. E., Oved, J. H., Avgousti, D. C., Toulmin, S. A., Zepp, J. A., Zacharias, W. J., Katzen, J. B., Basil, M. C., Kremp, M. M., Slamowitz, A. R., Jayachandran, S., Sivakumar, A., Dai, N., Wang, P., Frank, D. B., Eisenlohr, L. C., Cantu, E., Beers, M. F., … Worthen, G. S. (2020). STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nature Cell Biology, 1–14. https://doi.org/10.1038/s41556-020-0569-x Cite
Researchers used a randomized crossover experiment to estimate the effects of ozone exposure on genome-wide DNA methylation of target bronchial epithelial cells, using 17 volunteers, each randomly exposed on two separated occasions to clean air or 0.3-ppm ozone for two hours.
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Bind, M. -a. C., Rubin, D. B., Cardenas, A., Dhingra, R., Ward-Caviness, C., Liu, Z., Mirowsky, J., Schwartz, J. D., Diaz-Sanchez, D., & Devlin, R. B. (2020). Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study. Scientific Reports, 10(1), 15739. https://doi.org/10.1038/s41598-020-72068-6 Cite
Thereby Arg-Gly-Asp-Val-gemcitabine was able to inhibit the invasion, migration and adhesion of serum-starved A549 cells in vitro.
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Exploring the action of RGDV-gemcitabine on tumor metastasis, tumor growth and possible action pathway | Scientific Reports. (n.d.). Retrieved September 25, 2020, from https://www.nature.com/articles/s41598-020-72824-8 Cite
A549 and H1299 cell lines were screened out and their parent cells and drug-resistant cells were co-cultured with human bone marrow mesenchymal stem cells-derived exosomes that had been transfected with miR-193a mimic or si-LRRC1 to detect the colony formation, migration, apoptosis, invasion and proliferation of non-small cell lung cancer cells.
[Cell Death & Disease]
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Wu, H., Mu, X., Liu, L., Wu, H., Hu, X., Chen, L., Liu, J., Mu, Y., Yuan, F., Liu, W., & Zhao, Y. (2020). Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1. Cell Death & Disease, 11(9), 1–14. https://doi.org/10.1038/s41419-020-02962-4 Cite
Researchers showed that increased fibroblast growth factor receptor 1 (FGFR1) promoted tumorigenic progression in precancerous neuroendocrine cells and is required for small cell lung cancer development in vivo.
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Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death and in most cases it is often diagnosed at an advanced stage. Many genetic and microenvironmental factors are able to modify the cell cycle inducing carcinogenesis and tumor growth.
Scientists exposed the human alveolar A549 cell line to 0, 200, and 500 μg/mL quartz particles for 24 hours and used gas chromatography–mass spectrometry to measure the volatile metabolites in the headspace air of cells.
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