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Pulmonary Cell News
Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Super Multiple Primary Lung Cancers Harbor High-Frequency BRAF and Low-Frequency EGFR Mutations in the MAPK Pathway
[NPJ Precision Oncology] Researchers defined lung cancer with five or more primary lesions as super multiple primary lung cancer (MPLCs). Elucidating the genomic characteristics of this special MPLC subtype could help reduce disease burden and understand tumor evolution.
Spatial Transcriptomics of the Respiratory System
[Annual Review of Physiology] The authors review the most commonly used spatial analysis workflows, highlighting their advantages and limitations, and outline recent developments in machine learning and artificial intelligence that will augment how we interpret spatial data.
Multifaceted Roles of Mitochondria in Asthma
[Cell Biology and Toxicology] Investigators describe the changes in mitochondrial function in response to various exposure factors across different cell types and other relevant factors in the context of asthma, utilizing a new mitochondrial terminology framework that encompasses cell-dependent mitochondrial characteristics, molecular features, mitochondrial activity, function, and behavior.
A Lentiviral Toolkit to Monitor Airway Epithelial Cell Differentiation Using Bioluminescence
[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors used a lentiviral reporter gene approach to transduce primary human basal cells with bioluminescence reporter constructs to monitor airway epithelial differentiation longitudinally.
Suppression of Metastasis and Angiogenesis by Taxifolin Ruthenium- p-cymene Loaded PLGA Nanoparticles in Lung Carcinoma
[Molecular Pharmaceutics] Taxifolin ruthenium-p-cymene nanoparticle effectively alleviated lung cancer by activating p53-mediated apoptosis and preventing angiogenesis and metastasis by decreasing the VEGF/β-catenin pathway.
Nivolumab NSCLC Approval Expanded to Perioperative Setting
[Med] The US FDA has expanded the approval of nivolumab for the treatment of certain patients with resectable NSCLC.
TRβ Activation Confers AT2-to-AT1 Cell Differentiation and Anti-Fibrosis During Lung Repair via KLF2 and CEBPA
[Nature Communications] Investigators found that thyroid hormone was decreased in multiple models of lung injury but was essential for lung regeneration. Moreover, thyroid hormone receptor α promoted cell proliferation, while TRβ fueled cell maturation in lung regeneration.
A Clinically Effective Model Based on Cell-Free DNA Methylation and Low-Dose CT for Risk Stratification of Pulmonary Nodules
[Cell Reports Medicine] The authors performed genome-wide methylation sequencing on malignant and non-malignant lung tissues and designed a panel of 263 differential DNA methylation regions, which was used for targeted methylation sequencing on blood cell-free DNA in two prospectively collected and retrospectively analyzed multicenter cohorts.
GTSE1-Driven ZEB1 Stabilization Promotes Pulmonary Fibrosis Through the Epithelial-to-Mesenchymal Transition
[Molecular Therapy] Investigators explored the genomic data of patients with idiopathic PF (IPF) and found that GTSE1 expression is elevated in their lung tissues, but rarely expressed in normal lung tissues.
Serum β2-Microglobulin as an Independent Risk Factor for Mortality in Patients with Acute Respiratory Distress Syndrome Caused by Bacterial Infection
[Scientific Reports] Scientists retrospectively enrolled 257 patients with ARDS caused by bacterial infection from January 1, 2015 to February 28, 2021. Patients were followed for up to 28 days and were divided into a survival group and non-survival group according to their clinical outcomes.
Identification of DNA Methylation Markers for Age and Bovine Respiratory Disease in Dairy Cattle: A Pilot Study Based on Reduced Representation Bisulfite Sequencing
[Communications Biology] The authors performed a pilot study to investigate the epigenetic profile of BRD susceptibility in six calves and age-related methylation differences between healthy calves and adult dairy cows using Reduced Representation Bisulfite Sequencing.
The miRNA and PD-1/PD-L1 Signaling Axis: An Arsenal of Immunotherapeutic Targets Against Lung Cancer
[Cell Death Discovery] Investigators explored the role of miRNAs in modulating immunogenic responses against tumors. They discuss various aspects of how manipulating these checkpoints can bias the immune system’s response against lung cancer.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
