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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Clinical Multi-Dimensional Prognostic Nomogram for Predicting the Efficacy of Immunotherapy in NSCLC
[Scientific Reports] Scientists integrated clinical parameters, radiomic features, and immune signature data from NSCLC patients receiving immunotherapy to construct a multi-dimensional prediction model to better predict the efficacy of immunotherapy.
A Proposed Approach to Pulmonary Long COVID: A Viewpoint
[European Respiratory Journal] Investigators hypothesised that patients with long COVID with a predominance of pulmonary symptoms have airway pathology that can be detected using conventional as well as emerging technologies.
Exploring the Oncogenic Potential of Aiolos in Lung Cancer through OTUB1-Mediated Ubiquitination
[Heliyon] Research indicated that Aiolos overexpression enhances these cellular processes, suggesting its potential contribution to the advancement of the disease. However, the precise mechanisms underlying these effects require further investigation.
Comprehensive Analysis of scRNA-Seq and Bulk RNA-Seq Reveals Ubiquitin Promotes Pulmonary Fibrosis in Chronic Pulmonary Diseases
[Scientific Reports] Single-cell transcriptome data of human and mouse from GEO database were integrated by “Harmony” algorithm. The data was standardized and normalized by using “Seurat” package, and “SingleR” algorithm was used for cell grouping annotation.
Modelling SARS-CoV-2 Infection in a Human Alveolus Microphysiological System
[Access Microbiology] The authors describe the adaptation of a human alveolus microphysiological system model consisting of primary human alveolar epithelial and lung microvascular endothelial cells to study infection with SARS-CoV-2 at Biosafety Level 3 facility.
Characterization of Pre- and On-Treatment Soluble Immune Mediators and the Tumor Microenvironment in NSCLC Patients Receiving PD-1/L1 Inhibitor Monotherapy
[Cancer Immunology Immunotherapy] Among 183 patients with advanced or recurrent NSCLC who received immune checkpoint inhibitors (ICI) monotherapy, researchers analyzed 110 patients whose pre- and post-treatment plasma samples were available. Seventy-three soluble immune mediators were measured at ICI initiation and six weeks later.
Morphine Promotes Non-Small Cell Lung Cancer Progression by Downregulating E-Cadherin via the PI3K/AKT/mTOR Pathway
[Scientific Reports] Scientists employed immunofluorescence staining to evaluate E-cadherin expression in A549 and Lewis lung cancer cell lines and immunohistochemistry to evaluate E-cadherin expression in nude mice tumors.
Glutathione Inhibits Lung Cancer Development by Reducing Interleukin-6 Expression and Reversing the Warburg Effect
[Mitochondrion] 30 patients with pulmonary nodules were treated with GSH intravenously for ten days at a dose of 1.8 g/d, followed by oral administration of the drug at a dose of 0.4 g three times daily for six months.
Cell-Free and Extrachromosomal DNA Profiling of Small Cell Lung Cancer
[Trends In Molecular Medicine] The authors discuss how these cfDNA profiling modalities can be harnessed to expand the clinical applications of liquid biopsy in SCLC.
The Development of Lung Tissue Engineering: From Biomaterials to Multicellular Systems
[Advanced Healthcare Materials] The introduction of lung structure and lung injury are stated briefly at first. After that, the lung tissue-engineered constructs are categorized into three types: acellular, monocellular, and multicellular systems.
Key Lawmakers Are Wary of Giving FDA More Cash to Crack Down on E-Cigs
[STAT News] Powerful House lawmakers from both parties are skeptical of the Food and Drug Administration’s pitch to start collecting fees from e-cigarette companies, similar to how the agency assesses them on tobacco firms.
Spatially Resolved Whole-Transcriptomic and Proteomic Profiling of Lung Cancer and Its Immune-Microenvironment According to PD-L1 Expression
[Cancer Immunology Research] Using a Digital Spatial Profiling, investigators performed proteomic and whole-transcriptomic analyses of tumor cells and immune cells in spatially matched areas based on tumor PD-L1 expression and the status of the immune microenvironment.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
