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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Microplastics Exacerbate Ferroptosis via Mitochondrial Reactive Oxygen Species-Mediated Autophagy in Chronic Obstructive Pulmonary Disease
[Autophagy] Researchers demonstrated that microplastics intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis in vitro and in vivo.
Induction of Necroptosis in Lung Adenocarcinoma by mir‑10b‑5p through Modulation of the PKP3/RIPK3/MLKL Cascade
[Oncology Reports] Scientists elucidated the role and underlying mechanisms of miR‑10b‑5p in regulating necroptosis in the context of LUAD.
ZNF768 Loss Amplifies p53 Action and Reduces Lung Tumorigenesis in Mice
[Oncogene] Investigators reported the generation and characterization of a ZNF768 null mouse model. ZNF768 null mice were viable but showed a growth defect early in life.
The NcRNA/Wnt Axis in Lung Cancer: Oncogenic Mechanisms, Remarkable Indicators, and Therapeutic Targets
[Journal of Translational Medicine] The authors comprehensively review the regulatory mechanisms related to the functions of ncRNAs and the Wnt/β-catenin pathway in lung cancer.
Novel Selective Strategies Targeting the BCL-2 Family to Enhance Clinical Efficacy in ALK-Rearranged Non-Small Cell Lung Cancer
[Cell Death & Disease] Investigators found that dynamic BH3 profiling presented an excellent predictive capacity to anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors, that would facilitate their use in a clinical setting and complementing the readout of standard diagnostic assays.
RNA m7G Methylation Regulators and Targets Significantly Contribute to Chronic Obstructive Pulmonary Disease
[Scientific Reports] The combined roles of m7G methylation regulators were explored in COPD for the first time by integrated bioinformatic methods.
The Role of HDAC3 in Pulmonary Diseases
[Lung] Investigators systematically examine the structural and functional features of histone deacetylase 3 (HDAC3) and discuss its multifaceted contributions to pulmonary pathologies, including lung injury, pulmonary fibrosis, and lung cancer.
SMSbiotech Receives Green Light for Phase I Clinical Trial in Australia, Targeting COPD
[SMSbiotech ] SMSbiotech has announced a significant milestone in its pursuit of its regenerative medicine technology, securing approval to commence a Phase I clinical trial in Australia.
Nebulized 2-Deoxylated Glucose Analogs Inhibit Respiratory Viral Infection in Advanced In Vitro Airway Models
[Scientific Reports] Researchers investigated the antiviral and anti-inflammatory effect of three 2-deoxylated glucose analogs by utilizing advanced in vitro air-liquid interface airway models.
Therapeutic Strategies to Reverse Cigarette Smoke-Induced Ion Channel and Mucociliary Dysfunction in COPD Airway Epithelial Cells
[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors investigated whether the ion channel amplifier nesolicaftor rescued cigarette smoke-induced mucociliary and ion channel dysfunction.
DNA Polymerase Delta 2 Activates Cell Cycle in Lung Adenocarcinoma, Leading to High Malignancy and Poor Prognosis
[Annals of Surgical Oncology] Researchers investigated the relationship between polymerase delta 2 expression and tumor malignancy in lung adenocarcinoma cell lines.
o8g-Modified circPLCE1 Inhibits Lung Cancer Progression via Chaperone-Mediated Autophagy
[Molecular Cancer] Investigators identified differentially expressed circRNAs by RNA high-throughput sequencing and then conducted methylated RNA immunoprecipitation, immunofluorescence analysis, crosslinking immunoprecipitation, and actinomycin D assays to explore circPLCE1 8-oxoguanine (o8G) modification.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
