Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

Effect of Hyperhomocysteinemia on a Murine Model of Smoke-Induced Pulmonary Emphysema

[Scientific Reports] A549 cells (human alveolar epithelial cell line) were cultured with homocysteine and exposed to cigarette smoke extract to observe cell viability and expression of proteins related to the endoplasmic reticulum stress.

Overexpression of Decay Accelerating Factor Mitigates Fibrotic Responses to Lung Injury

[American Journal of Respiratory Cell and Molecular Biology] Scientists showed that overexpression of decay accelerating factor in fibrosed lungs limited fibrotic injury by restraining complement dysregulation.

Tumor-Polarized GPX3+ AT2 Lung Epithelial Cells Promote Premetastatic Niche Formation

[Proceedings of the National Academy of Sciences of the United States of America] Researchers identified a tumor-polarized subpopulation of alveolar type 2 (AT2) epithelial cells with increased expression of glutathione peroxidase 3 (GPX3) and high production of interleukin-10 in the premetastatic niche.

Tumor Necrosis Factor-α Coordinates With Transforming Growth Factor-β1 To Induce Epithelial-Mesenchymal Transition and Migration via the Nf-κB/NOX4 Pathway in Bronchial Epithelial Cells

[Molecular Biology Reports] Researchers investigated the effect of the proinflammatory cytokine tumor necrosis factor-α on transforming growth factor-β1-induced epithelial-to-mesenchymal transition and the underlying mechanisms in the human bronchial epithelial cell line, BEAS-2B.

Suppression of circXPO1 Attenuates Cigarette Smoke-Induced Inflammation and Cellular Senescence of Alveolar Epithelial Cells in Chronic Obstructive Pulmonary Disease

[International Immunopharmacology] Researchers investigated the function and fundamental mechanism of a novel circular RNA XPO1 (circXPO1) in cigarette smoke-induced inflammation and cellular senescence of alveolar epithelial cells.

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells

[Langmuir] Scientists utilized selectively modified, biodegradable polymer-based polyplexes to deliver custom, exogenous miR-148b mimics to induce apoptosis in human lung cancer (A549) cells.

Transcriptional Responses to Injury of Regenerative Lung Alveolar Epithelium

[iScience] Researchers mapped all proliferative alveolar epithelial type 2 cells in homeostatic and regenerating murine lungs after injury induced by Streptococcus pneumoniae infection.

House Dust Mite-Induced Akt-ERK1/2-C/Ebp Beta Pathway Triggers CCL20-Mediated Inflammation and Epithelial–Mesenchymal Transition for Airway Remodeling

[FASEB Journal] To investigate the role of C–C chemokine ligand 20 (CCL20) in chronic airway inflammation and remodeling, researchers made a mouse model of CCL20-induced bronchial asthma.

Transcriptomic Data Exploration of Consensus Genes and Molecular Mechanisms between Chronic Obstructive Pulmonary Disease and Lung Adenocarcinoma

[Scientific Reports] Investigators explored the unique and jointly molecular mechanisms in the pathogenesis of COPD and lung adenocarcinoma across several datasets based on a variety of analysis methods.

Measuring Cystic Fibrosis Drug Responses in Organoids Derived From 2D Differentiated Nasal Epithelia

[Life Science Alliance] Scientists described an alternative method of culturing nasal-brushing–derived airway organoids, which were created from an equally differentiated airway epithelial monolayer of a 2D air–liquid interface culture.

Ancestral SARS-CoV-2, but Not Omicron, Replicates Less Efficiently in Primary Pediatric Nasal Epithelial Cells

[PLoS Biology] Researchers used primary nasal epithelial cells (NECs) from children and adults, differentiated at an air–liquid interface to show that the ancestral SARS-CoV-2 replicated to significantly lower titers in the NECs of children compared to those of adults.

Tumor-Polarized GPX3+ AT2 Lung Epithelial Cells Promote Premetastatic Niche Formation

[Proceedings of the National Academy of Sciences of the United States of America] By single-cell sequencing, investigators identified a tumor-polarized subpopulation of alveolar type 2 (AT2) epithelial cells with increased expression of glutathione peroxidase 3 (GPX3) and high production of interleukin-10 in the premetastatic niche.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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