Identification of a Targetable KRAS-Mutant Epithelial Population in Non-small Cell Lung Cancer

Scientists investigated the effects of in vivo PTC596 treatment, which affects BMI-1 activity, in murine model.
[Communications Biology]
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PD-L1 lncRNA Splice Isoform Promotes Lung Adenocarcinoma Progression via Enhancing C-Myc Activity

Employing qRT-PCR, Sanger sequencing, and RNA BaseScope analysis, scientists showed that human lung adenocarcinoma (LUAD) all produce a long non-coding RNA isoform of programmed death-ligand 1 (PD-L1) (PD-L1-lnc) by alternative splicing, regardless if the tumor is positive or negative for the protein PD-L1.
[Genome Biology]
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Repression of the AURKA-CXCL5 Axis Induces Autophagic Cell Death and Promotes Radiosensitivity in Non-Small-Cell Lung Cancer

Researchers showed that Aurora inase A (AURKA) was upregulated in non-small-cell lung cancer (NSCLC) cell lines and tissues and that AURKA overexpression was significantly related to a poor prognosis, tumor stage and lymph node metastasis in NSCLC.
[Cancer Letters]
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SOD1 Regulates Ribosome Biogenesis in KRAS Mutant Non-small Cell Lung Cancer

Researchers describeed the generation of an inducible Sod1 knockout in KRAS-driven NSCLC mouse model.
[Nature Communications]
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Physiological and Inflammatory Consequences of High and Low Respiratory Rate in Acute Respiratory Distress Syndrome

In this narrative review, the authors present their point of view over the main experimental and clinical evidence available regarding the effect of respiratory rate on ventilator‐induced lung injury development.
[Acta Anaesthesiologica Scandinavica]
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Cyclica Teams Up with Top-Tier Academic Institutions to Identify a Repurposed Drug for COVID

Cyclica, in connection with leading Canadian research institutions, had predicted a drug, capmatinib, can be repurposed to attenuate the impact of coronavirus.
[Cyclica]
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Cardialen Announces Positive Results from Low-Voltage MultiPulse Therapy to Terminate Atrial Fibrillation

Cardialen, Inc., has published a first-in-human study in the Journal of the American College of Cardiology: Clinical Electrophysiology titled Novel Low-Voltage MultiPulse Therapy to Terminate Atrial Fibrillation.
[Cardialen (businesswire)]
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SCAMP3 Is a Mutant EGFR Phosphorylation Target and a Tumor Suppressor in Lung Adenocarcinoma

Scientist used quantitative mass-spectrometry-based phosphoproteomics to identify secretory carrier membrane proteins (SCAMP3) as a target of mutant epidermal growth factor receptor in lung adenocarcinoma and further investigated the role of SCAMP3 in the regulation of lung tumorigenesis.
[Oncogene]
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HIF-1α Promoted Vasculogenic Mimicry Formation in Lung Adenocarcinoma through NRP1 Upregulation in the Hypoxic Tumor Microenvironment

Researchers explored the role of the HIF-1α/NRP1 axis in mediating lung adenocarcinoma metastasis and vasculogenic mimicry (VM) formation.
[Cell Death & Disease]
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Distinct Uptake, Amplification, and Release of SARS-CoV-2 by M1 and M2 Alveolar Macrophages

Investigators showed that classically activated M1 alveolar macrophages (AMs) facilitated viral spread; however, alternatively activated M2 AMs limited the spread.
[Cell Discovery]
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Therapeutic Targeting of ATR Yields Durable Regressions in Small Cell Lung Cancers with High Replication Stress

Using chemical genetic screens, scientists identified inhibition of ataxia telangiectasia and rad3 related (ATR), the primary activator of the replication stress response, and topoisomerase I (TOP1), nuclear enzyme that suppressed genomic instability, as synergistically cytotoxic in small cell lung cancer (SCLC).
[Cancer Cell]
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