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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Prolonged Airway Explant Culture Enables Study of Health, Disease, and Viral Pathogenesis
[Science Advances] Investigators described methods to culture human large airway explants, small airway explants, and precision-cut lung slices for at least 14 days.
In Vivo Functional Screens Reveal KEAP1 Loss As a Driver of Chemoresistance in Small Cell Lung Cancer
[Science Advances] As small cell lung cancer patient-derived xenograft (PDX) models mimic therapeutic responses, scientists performed genetic screens in chemosensitive PDX models to identify drivers of chemoresistance.
Fangchinoline-Mediated Autophagy Inhibition Amplifies Antigen Presentation and PD-1 Blockade Efficacy in Lung Cancer
[Acta Pharmacologica Sinica] Researchers investigated the modulatory effects of PD-1 blockade combined with fangchinoline on CD8+ T cells within the tumor microenvironment of lung cancer.
Proteostasis Landscapes of Cystic Fibrosis Variants Reveal Drug Response Vulnerability
[Proceedings of The National Academy of Sciences of The United States of America] Using high-throughput interactomics, Rosetta simulations, and biochemical trafficking assays, scientists showed that poorly responsive cystic fibrosis variants experienced diverse misfolding pathways caused by structural defects in the core of a nucleotide-binding domain.
A METTL3-NFE2L3 Axis Mediates Tumor Stemness and Progression in Lung Adenocarcinoma
[Science Advances] Investigators identified that OV6+ tumor cells exhibited stem-like characteristics and were notably enriched in patients with non–major pathological response, closely associated with resistance to combination therapies.
Mechanism of Etoposide Resistance in Small Cell Lung Cancer and the Potential Therapeutic Options
[Medical Oncology] A small cell lung cancer cell line with etoposide-acquired resistance, H1048-ER, was constructed through a concentration gradient increasing method, and its resistance to etoposide was investigated in vitro and in a zebrafish model.
Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma
[Clinical Reviews in Allergy & Immunology] The authors systematically examine the roles of IL-4 and IL-13, key drivers of type-2 inflammation, in airway remodeling and their potential as therapeutic targets.
The Extracellular Matrix Protein Periostin Is Required for Wound Repair in Primary Human Airway Epithelia
[American Journal of Physiology-Lung Cellular and Molecular Physiology] Scientists investigated the role of periostin in airway epithelial and lung fibroblast wound repair using an in vitro' wound model.
RNase1-Driven ALK-Activation Is an Oncogenic Driver and Therapeutic Target in Non-Small Cell Lung Cancer
[Signal Transduction and Targeted Therapy] Scientists reported a non-canonical role of human secretory ribonuclease 1 (RNase1), which bound to and activated wild-type ALK in lung cancer cells, thereby triggering its downstream signaling pathway.
Induction of IL6/STAT3-Dependent TRAIL Expression That Contributes to the Therapeutic Efficacy of Osimertinib in EGFR Mutant NSCLC Cells
[Oncogene] Investigators found that osimertinib and other EGFR tyrosine kinase inhibitors increased the expression of umor necrosis factor-related apoptosis-inducing ligand (TRAIL) primarily in EGFR mutant NSCLC cell lines.
AHSA1-HSP90AA1 Complex Stabilized IFI6 and TGFB1 Promotes Mitochondrial Stability and EMT in EGFR-Mutated Lung Adenocarcinoma under Osimertinib Pressure
[Cell Death & Disease] Researchers found that the overexpression of IFI6 under the influence of the activator of HSP90AA1 ATPase Activity 1 (AHSA1)-HSP90AA1 complex significantly enhanced osimertinib resistance in epidermal growth factor receptor (EGFR)-mutated LUAD cells.
CCN1 Is a Therapeutic Target Upregulated in EML4-ALK Mutant Lung Adenocarcinoma Reversibly Resistant to Alectinib
[Cell Death & Disease] By performing RNA sequencing on reversible drug-resistant cell line to examine changes in transcriptional profile, significant change in CCN1 was detected after withdrawal and repeated administration of alectinib.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
