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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Dual Therapy with Corticosteroid Ablates the Beneficial Effect of DP2 Antagonism in Chronic Experimental Asthma
Using a preclinical model of chronic experimental asthma, investigators demonstrated that rhinovirus-induced exacerbations increased prostaglandin D2 release, mucus production, transforming growth factor-β1 and type-2...
ErbB Deletion Effect on Pulmonary Intracellular Surfactant Distribution
[Experimental Lung Research] Scientists hypothesized that ErbB4 deletion affected the ultrastructure of alveolar epithelial type II cells, specifically lamellar bodies and the intracellular distribution of the immunomodulating hydrophilic surfactant proteins (SP)-A and the hydrophobic SP-B.
Preclinical Studies on the Antitumor and Non-Toxic Effect of Combining Pirfenidone with Vinorelbine and Carboplatin in Non-Small Cell Lung Cancer
[International Journal of Cancer] Researchers performed preclinical studies on the combination of pirfenidone with vinorelbine, or with vinorelbine plus carboplatin, in NSCLC.
Efficacy and Mechanism of Combining Radiotherapy and Immunotherapy in Stage IV Non-Small Cell Lung Cancer
[Current Treatment Options In Oncology] Scientists explore the efficacy and safety of combining radiotherapy with immunotherapy in the treatment of stage IV NSCLC, delving into the intricacies of their underlying mechanism.
Merus Announces FDA Approval of BIZENGRI® (zenocutuzumab-zbco) for NRG1+ Pancreatic Adenocarcinoma and NRG1+ Non–Small Cell Lung Cancer (NSCLC) Based on Safety and Efficacy Data...
[Merus, N.V.] Merus, N.V. announced that the US FDA approved BIZENGRI®, a treatment indicated for adults with pancreatic adenocarcinoma or NSCLC that are advanced unresectable or metastatic and harbor a neuregulin 1 (NRG1) gene fusion who have disease progression on or after prior systemic therapy.
CCDC34 Maintains Stemness Phenotype Through β-Catenin-Mediated Autophagy and Promotes EGFR-TKI Resistance in Lung Adenocarcinoma
[Cancer Gene Therapy] Scientists found that CCDC34 may be associated with lung adenocarcinoma stemness through weighted gene co-expression network analysis.
Co-Culture of Human AT2 Cells with Fibroblasts Reveals a MUC5B Phenotype: Insights from an Organoid Model
[Molecular Medicine] Researcher analyzed the interaction of primary fibroblasts and alveolar type 2 pneumocytes in the organoid model. Single-cell analysis, histology, and qRT-PCR revealed that fibroblasts expressing high levels of fibrosis markers regulated STAT3 signaling in AT2 cells, which is accompanied by cystic organoid growth and MUC5B expression.
Ficolin-1 Ameliorates Pulmonary Fibrosis via Directly Binding to TGF-β1
[Journal of Translational Medicine] The expression of ficolin-1 in the plasma of idiopathic pulmonary fibrosis and connective tissue disease- interstitial lung disease patients was first determined.
Impact of Fluid Balance on the Development of Lung Injury
[American Journal of Respiratory and Critical Care Medicine] Thirty-nine healthy female pigs, divided into four groups, were ventilated for 48 hours with high or low mechanical power; and high or low targeted fluid balance.
The Role of PM2.5 Exposure in Lung Cancer: Mechanisms, Genetic Factors, and Clinical Implications
[EMBO Molecular Medicine] The authors summarize the current understanding of how exposure to PM2.5 induces lung carcinogenesis and accelerates lung cancer development.
Obesity-Specific Improvement of Lung Cancer Outcomes and Immunotherapy Efficacy with Metformin
[JNCI-Journal of The National Cancer Institute] Investigators hypothesized that metformin could benefit obese and overweight patients with NSCLC. They retrospectively analyzed two clinical cohorts and employed complementary mouse models to test their hypothesis. One cohort included NSCLC patients with overweight BMI and non-overweight BMI who underwent lobectomy.
A STAT3–STING–IFN Axis Controls the Metastatic Spread of Small Cell Lung Cancer
[Nature Immunology] Researchers showed that, while STAT3 deletion restricted primary tumor growth, it paradoxically enhanced metastatic spread by promoting immune evasion.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
