Category Archives: Pulmonary Cell

Pulmonary Cell News is an online publication and email newsletter dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

Genome Researchers Question Security Provisions in New US Senate Bill

Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science]
Editorial
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Praedicare Inc. Receives Grant to Evaluate Potential New Drug Regimens for Tuberculosis

Praedicare Inc., announced it has been awarded a two-year, $2.8 million grant by the Bill & Melinda Gates Foundation to evaluate novel Tuberculosis (TB) drug regimens using Praedicare’s in vitro hollow fiber model of TB in identifying potential new drug regimens that shorten treatment times for the disease.
[Praedicare Inc. (BusinessWire, Inc.)]
Press Release
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PulmoSIM Therapeutics Granted Orphan Drug Designation for PT001 by the FDA to Treat Pulmonary Arterial Hypertension

PulmoSIM Therapeutics, announced that the US FDA has granted orphan drug designation for asset PT001 for the treatment of Pulmonary Arterial Hypertension.
[PulmoSIM Therapeutics, Inc.]
Press Release
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CF Foundation Launches New Collaboration with Deep Science Ventures to Overcome Challenges to Developing Genetic Therapies for CF

CF Foundation announced a new collaboration with venture creator Deep Science Ventures, focused on uncovering and designing new technologies with the potential to overcome challenges to developing genetic therapies for cystic fibrosis.
[CF Foundation (BuisnessWire, Inc.)]
Press Release
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PGC-1α Mediates a Metabolic Host Defense Response in Human Airway Epithelium during Rhinovirus Infections

Researchers observed that early Human rhinoviruses (HRV)-C15 infection induced a transitory barrier-protective metabolic state characterized by glycolysis that ultimately became exhausted as the infection progresses and led to cellular damage.
[Nature Communications]
Michi, A. N., Yipp, B. G., Dufour, A., Lopes, F., & Proud, D. (2021). PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections. Nature Communications, 12(1), 3669. https://doi.org/10.1038/s41467-021-23925-z Cite
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Airway Basal Stem Cells Reutilize the Embryonic Proliferation Regulator, Tgfβ-Id2 Axis, for Tissue Regeneration

Using temporal single-cell transcriptomics of developing murine airway progenitors and genetic validation experiments, scientists found that TGF-β signaling decelerated cell cycle by inhibiting Id2 and contributed to slow-cycling basal cell specification during development.
[Developmental Cell]
Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration. (2021). Developmental Cell. https://doi.org/10.1016/j.devcel.2021.05.016 Cite
AbstractGraphical Abstract
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Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza

Using isogenic mutants of Streptococcus pneumoniae , investigators showed that Pneumococcal surface protein A – glyceraldehyde-3-phosphate dehydrogenase – mediated binding to lung cells increased pneumococcal localization in the lower airway, and this was enhanced as a result of pneumolysin exposure or co-infection with influenza A virus.
[Cell Reports]
Park, S.-S., Gonzalez-Juarbe, N., Riegler, A. N., Im, H., Hale, Y., Platt, M. P., Croney, C., Briles, D. E., & Orihuela, C. J. (2021). Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza. Cell Reports, 35(11). https://doi.org/10.1016/j.celrep.2021.109267 Cite
Full ArticleGraphical Abstract
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Single-Cell RNA Sequencing Identify SDCBP in ACE2-Positive Bronchial Epithelial Cells Negatively Correlates with COVID-19 Severity

Since angiotensin-converting enzyme 2 (ACE2)-positive cells were hosts for COVID-19, researchers focussed on this cell type to explore the underlying mechanisms of COVID-19.
[Journal of Cellular and Molecular Medicine]
Ma, D., Liu, S., Hu, L., He, Q., Shi, W., Yan, D., Cao, Y., Zhang, G., Wang, Z., Wu, J., & Jiang, C. (n.d.). Single-cell RNA sequencing identify SDCBP in ACE2-positive bronchial epithelial cells negatively correlates with COVID-19 severity. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16714 Cite
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AMPK Activates Parkin Independent Autophagy and Improves Post Sepsis Immune Defense against Secondary Bacterial Lung Infections

Scientists showed acquired Parkin and AMPK deficiency in leukocytes of post-sepsis immunosuppression from human subjects and mice.
[Scientific Reports]
Bone, N. B., Becker, E. J., Husain, M., Jiang, S., Zmijewska, A. A., Park, D.-W., Chacko, B., Darley-Usmar, V., Grégoire, M., Tadie, J.-M., Thannickal, V. J., & Zmijewski, J. W. (2021). AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections. Scientific Reports, 11(1), 12387. https://doi.org/10.1038/s41598-021-90573-0 Cite
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Remodeling of Bronchial Epithelium Caused by Asthmatic Inflammation Affects Its Response to Rhinovirus Infection

Investigators analyzed gene expression response in in vitro differentiated bronchial epithelium exposed to cytokines and next infected with Human rhinoviruses 16.
[Scientific Reports]
Jakiela, B., Rebane, A., Soja, J., Bazan-Socha, S., Laanesoo, A., Plutecka, H., Surmiak, M., Sanak, M., Sladek, K., & Bochenek, G. (2021). Remodeling of bronchial epithelium caused by asthmatic inflammation affects its response to rhinovirus infection. Scientific Reports, 11(1), 12821. https://doi.org/10.1038/s41598-021-92252-6 Cite
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Tissue-Resident Macrophages Provide a Pro-tumorigenic Niche to Early NSCLC Cells

To explore the diversity of the macrophage compartment in human non-small cell lung carcinoma (NSCLC) lesions, researchers performed single-cell RNA sequencing of tumour-associated leukocytes.
[Nature]
Casanova-Acebes, M., Dalla, E., Leader, A. M., LeBerichel, J., Nikolic, J., Morales, B. M., Brown, M., Chang, C., Troncoso, L., Chen, S. T., Sastre-Perona, A., Park, M. D., Tabachnikova, A., Dhainaut, M., Hamon, P., Maier, B., Sawai, C. M., Agulló-Pascual, E., Schober, M., … Merad, M. (2021). Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature, 1–7. https://doi.org/10.1038/s41586-021-03651-8 Cite
Abstract
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