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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Rab43 Mitigates the Inflammatory Response in Acute Lung Injury via MyD88 Ubiquitination
[Scientific Reports] Myeloid-specific Rab43 knockout mice were generated and used to construct a mouse model of acute lung injury after airway administration by lipopolysaccharides.
KMT2D Loss Drives Adeno-to-Squamous Transition and Sensitizes TKI-Resistant Lung Cancer to AURKA Inhibition
[Cell Death & Differentiation] The authors identified loss of the histone methyltransferase KMT2D as a critical event that disrupts adenocarcinoma lineage fidelity and promotes squamous transition.
An H4K12la/CEBPB-AKR1C2 Signaling Axis Modulates the mTOR Pathway to Regulate Cisplatin Resistance in Lung Cancer
[Oncogene] Scientists demonstrated that histone lactylation is closely associated with cisplatin resistance and correlates with poor prognosis of NSCLC.
HDAC6 Orchestrates Metastatic and Immunosuppressive Programs in Small Cell Lung Cancer through S100A2-TGF-β/SMAD and CSF1R Signaling
[Molecular Cancer] Preclinical SCLC models were utilized alongside molecular, cellular, and immunological techniques to elucidate histone deacetylase 6 (HDAC6)'s mechanistic functions.
UCHL1 Stabilizes Twist1 via K11/K63-Linked Deubiquitination to Drive Tumor Metastasis in Non-Small Cell Lung Cancer
[Cell Death Discovery] Scientists demonstrated that ubiquitin C-terminal hydrolase L1 (UCHL1) is upregulated in NSCLC and drives tumor metastatic progression.
Sbno2-Mediated Tissue-Resident Alveolar Macrophages: A Novel Therapeutic Axis for Sepsis-Induced Acute Lung Injury
[Cell Death Discovery] Researchers investigated the role of Sbno2-expressing tissue-resident alveolar macrophages in promoting alveolar epithelial cell regeneration and barrier function in sepsis-induced acute lung injury.
PARP1 Stabilizes FOXN3 to Suppress Pulmonary Fibrosis through p38-Related Feedback Regulation
[Science Advances] Investigators identified poly(ADP-ribose) polymerase–1 (PARP1) as a stabilizing partner of FOXN3, preventing its degradation by blocking p38-mediated phosphorylation.
MRPL17 Is a Critical Regulator of Mitochondrial Function and a Novel Therapeutic Target in Non-Small Cell Lung Cancer
[Cell Death & Disease] Researchers investigated the role of the mitochondrial protein mitochondrial ribosomal protein L17 (MRPL17) in NSCLC, exploring its expression profile, clinical significance, and therapeutic potential.
Dysregulated Alveolar Type 2 Epithelial Cell Proteostasis Promotes Fibrogenic Macrophage Migration Inhibitory Factor-CD74 Signaling
[Science Translational Medicine] Scientists showed that ubiquitin-proteasome system disruption in alveolar type 2 epithelial cells amplifies profibrotic signaling to macrophages through macrophage migration inhibitory factor family proteins in several models.
Methylated circPTK2 As a Driver of Fibroblast Activation in Pulmonary Fibrosis
[Molecular Therapy] Researchers identified circPTK2, a fibroblast-specific circular RNA that is significantly upregulated in pulmonary fibrosis patients and experimental models.
High-Throughput Isolation of Normal and Pulmonary Fibrosis Human Alveolar Epithelial Cells
[Scientific Reports] Investigators presented a comprehensive workflow for the isolation and culture of primary human AT2 cells, including an efficient enzyme-based lung tissue digestion protocol and automated purification of human alveolar type 2 cells from both healthy and diseased lungs.
KDM6B Induces Demethylation of H3K27me3 in MFN1 to Modulate Aberrant Mitophagy in Sepsis-Induced Acute Lung Injury
[Scientific Reports] The authors investigated the impact of KDM6B on macrophage processes during sepsis-induced acute lung injury and elucidated the underlying molecular mechanisms.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
