Using a lipidomic screen, scientists found that PLCγ1 was suppressed during hypoxia in KRAS-mutant human lung adenocarcinoma cancer cell lines.
[Nature Cell Biology]
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Saliakoura, M., Rossi Sebastiano, M., Pozzato, C., Heidel, F. H., Schnöder, T. M., Savic Prince, S., Bubendorf, L., Pinton, P., A. Schmid, R., Baumgartner, J., Freigang, S., Berezowska, S. A., Rimessi, A., & Konstantinidou, G. (2020). PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Nature Cell Biology, 1–14. https://doi.org/10.1038/s41556-020-00592-8 Cite
The expression levels of CIB1 in lung adenocarcinoma tissues and adjacent normal tissues were examined by immunohistochemistry, and the relationship between CIB1 expression and patient clinicopathological characteristics was analyzed.
[Cell Death & Differentiation]
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To investigate which oncogenic drivers co-operate with Zmat3 loss to promote neoplastic transformation, researchers utilized Zmat3 knockout mice in models of c-MYC-driven lymphomagenesis and KrasG12D-driven lung adenocarcinoma development.
[Cell Death & Disease]
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Best, S. A., Vandenberg, C. J., Abad, E., Whitehead, L., Guiu, L., Ding, S., Brennan, M. S., Strasser, A., Herold, M. J., Sutherland, K. D., & Janic, A. (2020). Consequences of Zmat3 loss in c-MYC - and mutant KRAS -driven tumorigenesis. Cell Death & Disease, 11(10), 1–9. https://doi.org/10.1038/s41419-020-03066-9 Cite
Scientists analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2.
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The differential lncRNAs were screened by microarray assay, then the expression was detected in LUAD tumor tissues and cell lines by qPCR. The influence on radiation response was assessed via in vitro and in vivo assays, and autophagy levels were evaluated by western blot and transmission electron microscopy.
[Cell Death & Disease]
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He, H., Song, X., Yang, Z., Mao, Y., Zhang, K., Wang, Y., Su, B., Li, Q., Chen, H., & Li, Y. (2020). Upregulation of KCNQ1OT1 promotes resistance to stereotactic body radiotherapy in lung adenocarcinoma by inducing ATG5/ATG12-mediated autophagy via miR-372-3p. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03083-8 Cite
The authors identified RFPL3 as a potential import cargo for IPO13, which was found to be overexpressed in NSCLC cells and tissues.
[Cell Death & Disease]
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Zohud, B. A., Guo, P., Zohud, B. A., Li, F., Hao, J. J., Shan, X., Yu, W., Guo, W., Qin, Y., & Cai, X. (2020). Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation. Cell Death & Disease, 11(10), 1–15. https://doi.org/10.1038/s41419-020-03101-9 Cite
By integrating profiles of H3K27Ac chromatin immunoprecipitation sequencing from normal adult lung and lung adenocarcinoma cell lines, researchers revealed that widespread alterations of the super-enhancer were present during lung carcinogenesis.
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Investigators uncovered that ERK3, a ubiquitously expressed atypical MAPK, was required for KRAS-mediated NSCLC tumors. ERK3 is highly expressed in lung cancers, and oncogenic KRAS led to the activation and stabilization of the ERK3 protein.
[Cancer Gene Therapy]
The authors report a physiologically relevant assay enabling quantitative analysis of metastatic capacity of tumor cells following implantation into the CAM. Engraftment of as few as 103 non-small cell lung cancer and prostate cancer cell lines was sufficient for both primary tumor and metastasis formation.
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Pawlikowska, P., Tayoun, T., Oulhen, M., Faugeroux, V., Rouffiac, V., Aberlenc, A., Pommier, A. L., Honore, A., Marty, V., Bawa, O., Lacroix, L., Scoazec, J. Y., Chauchereau, A., Laplace-Builhe, C., & Farace, F. (2020). Exploitation of the chick embryo chorioallantoic membrane (CAM) as a platform for anti-metastatic drug testing. Scientific Reports, 10(1), 16876. https://doi.org/10.1038/s41598-020-73632-w Cite
WJ-MSCs were encapsulated in 3D hydrogels derived from human fibrin or platelet lysate and the oxygen level was adjusted to physiological normoxia (5% O2).
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Biomimetic microenvironmental preconditioning enhance neuroprotective properties of human mesenchymal stem cells derived from Wharton’s Jelly (WJ-MSCs) | Scientific Reports. (n.d.). Retrieved October 13, 2020, from https://www.nature.com/articles/s41598-020-74066-0 Cite
The role of S6K1 in tyrosine kinase inhibitor resistance was determined in in vitro gain-and-loss of function studies and confirmed in subcutaneous and orthotopic mouse lung cancer models.
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Shen, H., Wang, G.-C., Li, X., Ge, X., Wang, M., Shi, Z.-M., Bhardwaj, V., Wang, Z.-X., Zinner, R. G., Peiper, S. C., Aplin, A. E., Jiang, B.-H., & He, J. (2020). S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01497-4 Cite