PLCγ1 Suppression Promotes the Adaptation of KRAS-Mutant Lung Adenocarcinomas to Hypoxia

Using a lipidomic screen, scientists found that PLCγ1 was suppressed during hypoxia in KRAS-mutant human lung adenocarcinoma cancer cell lines.
[Nature Cell Biology]
Saliakoura, M., Rossi Sebastiano, M., Pozzato, C., Heidel, F. H., Schnöder, T. M., Savic Prince, S., Bubendorf, L., Pinton, P., A. Schmid, R., Baumgartner, J., Freigang, S., Berezowska, S. A., Rimessi, A., & Konstantinidou, G. (2020). PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Nature Cell Biology, 1–14. https://doi.org/10.1038/s41556-020-00592-8 Cite
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CHIP-Mediated CIB1 Ubiquitination Regulated Epithelial–Mesenchymal Transition and Tumor Metastasis in Lung Adenocarcinoma

The expression levels of CIB1 in lung adenocarcinoma tissues and adjacent normal tissues were examined by immunohistochemistry, and the relationship between CIB1 expression and patient clinicopathological characteristics was analyzed.
[Cell Death & Differentiation]
Liu, Y., Zhou, Y., Zhang, P., Li, X., Duan, C., & Zhang, C. (2020). CHIP-mediated CIB1 ubiquitination regulated epithelial–mesenchymal transition and tumor metastasis in lung adenocarcinoma. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-00635-5 Cite
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Consequences of Zmat3 Loss in c-MYC– and Mutant KRAS-Driven Tumorigenesis

To investigate which oncogenic drivers co-operate with Zmat3 loss to promote neoplastic transformation, researchers utilized Zmat3 knockout mice in models of c-MYC-driven lymphomagenesis and KrasG12D-driven lung adenocarcinoma development.
[Cell Death & Disease]
Best, S. A., Vandenberg, C. J., Abad, E., Whitehead, L., Guiu, L., Ding, S., Brennan, M. S., Strasser, A., Herold, M. J., Sutherland, K. D., & Janic, A. (2020). Consequences of Zmat3 loss in c-MYC - and mutant KRAS -driven tumorigenesis. Cell Death & Disease, 11(10), 1–9. https://doi.org/10.1038/s41419-020-03066-9 Cite
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Expression of SARS-CoV-2 Entry Factors in Lung Epithelial Stem Cells and Its Potential Implications for COVID-19

Scientists analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2.
[Scientific Reports]
Valyaeva, A. A., Zharikova, A. A., Kasianov, A. S., Vassetzky, Y. S., & Sheval, E. V. (2020). Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19. Scientific Reports, 10(1), 17772. https://doi.org/10.1038/s41598-020-74598-5 Cite
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Upregulation of KCNQ1OT1 Promotes Resistance to Stereotactic Body Radiotherapy in Lung Adenocarcinoma by Inducing ATG5/ATG12-Mediated Autophagy via miR-372-3p

The differential lncRNAs were screened by microarray assay, then the expression was detected in LUAD tumor tissues and cell lines by qPCR. The influence on radiation response was assessed via in vitro and in vivo assays, and autophagy levels were evaluated by western blot and transmission electron microscopy.
[Cell Death & Disease]
He, H., Song, X., Yang, Z., Mao, Y., Zhang, K., Wang, Y., Su, B., Li, Q., Chen, H., & Li, Y. (2020). Upregulation of KCNQ1OT1 promotes resistance to stereotactic body radiotherapy in lung adenocarcinoma by inducing ATG5/ATG12-mediated autophagy via miR-372-3p. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03083-8 Cite
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Importin 13 Promotes NSCLC Progression by Mediating RFPL3 Nuclear Translocation and hTERT Expression Upregulation

The authors identified RFPL3 as a potential import cargo for IPO13, which was found to be overexpressed in NSCLC cells and tissues.
[Cell Death & Disease]
Zohud, B. A., Guo, P., Zohud, B. A., Li, F., Hao, J. J., Shan, X., Yu, W., Guo, W., Qin, Y., & Cai, X. (2020). Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation. Cell Death & Disease, 11(10), 1–15. https://doi.org/10.1038/s41419-020-03101-9 Cite
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Aberrant Super-Enhancer Landscape Reveals Core Transcriptional Regulatory Circuitry in Lung Adenocarcinoma

By integrating profiles of H3K27Ac chromatin immunoprecipitation sequencing from normal adult lung and lung adenocarcinoma cell lines, researchers revealed that widespread alterations of the super-enhancer were present during lung carcinogenesis.
[Oncogenesis]
Zhang, T., Song, X., Zhang, Z., Mao, Q., Xia, W., Xu, L., Jiang, F., & Dong, G. (2020). Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma. Oncogenesis, 9(10), 1–12. https://doi.org/10.1038/s41389-020-00277-9 Cite
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ERK3/MAPK6 Is Required for KRAS-Mediated NSCLC Tumorigenesis

Investigators uncovered that ERK3, a ubiquitously expressed atypical MAPK, was required for KRAS-mediated NSCLC tumors. ERK3 is highly expressed in lung cancers, and oncogenic KRAS led to the activation and stabilization of the ERK3 protein.
[Cancer Gene Therapy]
Bogucka, K., Marini, F., Rosigkeit, S., Schloeder, J., Jonuleit, H., David, K., Schlackow, M., & Rajalingam, K. (2020). ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis. Cancer Gene Therapy, 1–16. https://doi.org/10.1038/s41417-020-00245-w Cite
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Exploitation of the Chick Embryo Chorioallantoic Membrane (CAM) as a Platform for Anti-Metastatic Drug Testing

The authors report a physiologically relevant assay enabling quantitative analysis of metastatic capacity of tumor cells following implantation into the CAM. Engraftment of as few as 103 non-small cell lung cancer and prostate cancer cell lines was sufficient for both primary tumor and metastasis formation.
[Scientific Reports]
Pawlikowska, P., Tayoun, T., Oulhen, M., Faugeroux, V., Rouffiac, V., Aberlenc, A., Pommier, A. L., Honore, A., Marty, V., Bawa, O., Lacroix, L., Scoazec, J. Y., Chauchereau, A., Laplace-Builhe, C., & Farace, F. (2020). Exploitation of the chick embryo chorioallantoic membrane (CAM) as a platform for anti-metastatic drug testing. Scientific Reports, 10(1), 16876. https://doi.org/10.1038/s41598-020-73632-w Cite
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Biomimetic Microenvironmental Preconditioning Enhance Neuroprotective Properties of Human Mesenchymal Stem Cells Derived From Wharton’s Jelly (WJ-MSCs)

WJ-MSCs were encapsulated in 3D hydrogels derived from human fibrin or platelet lysate and the oxygen level was adjusted to physiological normoxia (5% O2).
[Scientific Reports]
Biomimetic microenvironmental preconditioning enhance neuroprotective properties of human mesenchymal stem cells derived from Wharton’s Jelly (WJ-MSCs) | Scientific Reports. (n.d.). Retrieved October 13, 2020, from https://www.nature.com/articles/s41598-020-74066-0 Cite
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S6K1 Blockade Overcomes Acquired Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer

The role of S6K1 in tyrosine kinase inhibitor resistance was determined in in vitro gain-and-loss of function studies and confirmed in subcutaneous and orthotopic mouse lung cancer models.
[Oncogene]
Shen, H., Wang, G.-C., Li, X., Ge, X., Wang, M., Shi, Z.-M., Bhardwaj, V., Wang, Z.-X., Zinner, R. G., Peiper, S. C., Aplin, A. E., Jiang, B.-H., & He, J. (2020). S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01497-4 Cite
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