Category Archives: Pulmonary Cell

Pulmonary Cell News is an online publication and email newsletter dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

An RFC4/Notch1 Signaling Feedback Loop Promotes NSCLC Metastasis and Stemness

To understand how Notch signaling was overactivated to couple tumor metastasis and self-renewal in NSCLC cells, researchers showed that RFC4, directly bound to the Notch1 intracellular domain (NICD1) to competitively abrogate CDK8/FBXW7-mediated degradation of NICD1.
[Nature Communications]
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First Time in Thailand – Chula Successfully Uses Stem-Cell Transplantation to Treat Systemic Sclerosis Patients with Pulmonary Fibrosis

The faculty of medicine at Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society , in collaboration with the Departments of Hematology, Pulmonary and Critical Care Medicine, and Infectious diseases, held a press conference on “Thailand’s first successful treatment of systemic sclerosis patients with pulmonary fibrosis by stem cell transplantation“.
[Chulalongkorn University (Newswise, Inc.)]
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Lung Cancer Organoids Analyzed on Microwell Arrays Predict Drug Responses of Patients within a Week

The authors adapted a mechanical sample processing method to generate lung cancer organoids from surgically resected and biopsy tumor tissues.
[Nature Communications]
Hu, Y., Sui, X., Song, F., Li, Y., Li, K., Chen, Z., Yang, F., Chen, X., Zhang, Y., Wang, X., Liu, Q., Li, C., Zou, B., Chen, X., Wang, J., & Liu, P. (2021). Lung cancer organoids analyzed on microwell arrays predict drug responses of patients within a week. Nature Communications, 12(1), 2581. https://doi.org/10.1038/s41467-021-22676-1 Cite
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Fibroblast CEBPD/SDF4 Axis in Response to Chemotherapy-Induced Angiogenesis through CXCR4

The authors found that cisplatin and 5-fluorouracil could induce fibroblast differentiation toward myofibroblasts via CCAAT/enhancer-binding protein delta and consequently promote proliferation, migration, and in vitro tube formation of vascular endothelial cells and angiogenesis in vivo.
[Cell Death & Discovery]
Chi, J.-Y., Hsiao, Y.-W., Liu, H.-L., Fan, X.-J., Wan, X.-B., Liu, T.-L., Hung, S.-J., Chen, Y.-T., Liang, H.-Y., & Wang, J.-M. (2021). Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4. Cell Death Discovery, 7(1), 1–16. https://doi.org/10.1038/s41420-021-00478-0 Cite
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EGFR-ERK Induced Activation of GRHL1 Promotes Cell Cycle Progression by Up-Regulating Cell Cycle Related Genes in Lung Cancer

Scientists found that GRHL1 was upregulated in non-small cell lung cancer and correlated with poor survival of patients.
[Cell Death & Disease]
He, Y., Gan, M., Wang, Y., Huang, T., Wang, J., Han, T., & Yu, B. (2021). EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer. Cell Death & Disease, 12(5), 1–13. https://doi.org/10.1038/s41419-021-03721-9 Cite
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Potential Role for EZH2 in Promotion of Asthma through Suppression of miR-34b Transcription by Inhibition of FOXO3

Researchers investigated the molecular mechanism of enhancer of zeste homolog 2 (EZH2) in the development of asthma.
[Laboratory Investigation]
Liu, B., Sun, H., Wang, J., Liu, H., & Zhao, C. (2021). Potential role for EZH2 in promotion of asthma through suppression of miR-34b transcription by inhibition of FOXO3. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-021-00585-7 Cite
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Differential Chromatin Binding of the Lung Lineage Transcription Factor NKX2-1 Resolves Opposing Murine Alveolar Cell Fates In Vivo

Scientists reported that the cell-type-specific function of NKX2-1 was attributed to its differential chromatin binding that was acquired or retained during development in coordination with partner transcriptional factors.
[Nature Communications]
Little, D. R., Lynch, A. M., Yan, Y., Akiyama, H., Kimura, S., & Chen, J. (2021). Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo. Nature Communications, 12(1), 2509. https://doi.org/10.1038/s41467-021-22817-6 Cite
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Reversed-Engineered Human Alveolar Lung-on-a-Chip Model

[Proceedings of the National Academy of Sciences of the United States of America]
Huang, D., Liu, T., Liao, J., Maharjan, S., Xie, X., Pérez, M., Anaya, I., Wang, S., Mayer, A. T., Kang, Z., Kong, W., Mainardi, V. L., Garciamendez-Mijares, C. E., Martínez, G. G., Moretti, M., Zhang, W., Gu, Z., Ghaemmaghami, A. M., & Zhang, Y. S. (2021). Reversed-engineered human alveolar lung-on-a-chip model. Proceedings of the National Academy of Sciences, 118(19). https://doi.org/10.1073/pnas.2016146118 Cite
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Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non-small Cell Lung Cancer

Researchers investigated the acquired resistance mechanism of epidermal growth factor receptor kinase domain duplication (EGFR-KDD) against EGFR-tyrosine kinase inhibitors (EGFR TKIs).
[Cancer Research and Treatment]
Lee, C., Kim, M., Kim, D.-W., Kim, T. M., Kim, S., Im, S.-W., Jeon, Y. K., Keam, B., Ku, J.-L., & Heo, D. S. (2021). Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non-Small Cell Lung Cancer. Cancer Research and Treatment. https://doi.org/.0.0.0 Cite
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Lung Carcinoid Tumors with Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) Exhibit Pejorative Pathological Features

[Lung Cancer]
Prieto, M., Chassagnon, G., Lupo, A., Charpentier, M.-C., Cabanne, E., Groussin, L., Wislez, M., Alifano, M., & Fournel, L. (2021). Lung carcinoid tumors with Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) exhibit pejorative pathological features. Lung Cancer, 156, 117–121. https://doi.org/10.1016/j.lungcan.2021.04.024 Cite
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Single-Cell Profiling of Tumor Heterogeneity and the Microenvironment in Advanced Non-small Cell Lung Cancer

we analyze 42 tissue biopsy samples from stage III/IV non-small cell lung cancer (NSCLC) patients by single cell RNA sequencing and present the large scale, single cell resolution profiles of advanced NSCLCs.
[Nature Communications]
Wu, F., Fan, J., He, Y., Xiong, A., Yu, J., Li, Y., Zhang, Y., Zhao, W., Zhou, F., Li, W., Zhang, J., Zhang, X., Qiao, M., Gao, G., Chen, S., Chen, X., Li, X., Hou, L., Wu, C., … Zhou, C. (2021). Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nature Communications, 12(1), 2540. https://doi.org/10.1038/s41467-021-22801-0 Cite
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