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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Inhalable Polymeric PROTAC Nanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis
[Journal of the American Chemical Society] Researchers developed an inhalable enzyme-activated polymeric proteolysis-targeting chimera (PROTAC) nanococktail that enables concurrent degradation of two key profibrotic signaling regulators in fibrotic lungs.
Foxe1 Deficiency Impairs Thyroid Fate While Supporting Lung Differentiation
[EMBO Reports] By using mouse stem cell lines, scRNA-seq, and transcriptomic and chromatin accessibility profiling, scientists showed that Foxe1 knockout impairs Nkx2-1+ cell differentiation and maturation into thyroid follicular-like cells.
Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis
[Cancer Discovery] Investigators discovered that breast cancer–derived lung metastases stimulate the proliferation of alveolar type II (AT2) cells in their vicinity and reprogram them into lipid feeder cells in mice and patients using spatial analysis.
KLF15 Activates PGC1α to Rewire Mitochondrial Homeostasis and Overcome Cisplatin Resistance in Lung Adenocarcinoma
[Cell Death Discovery] The authors demonstrated that the transcription factor KLF15 governs cisplatin sensitivity by orchestrating mitochondrial biogenesis and redox homeostasis.
TMEM33 Regulates the Proliferation and Migration of Lung Adenocarcinoma by Promoting the PI3K/AKT/mTOR Signaling Pathway
[Cancer Cell International] Researchers identified TMEM33 as a driver of lung adenocarcinoma progression, promoting tumor growth and migration through activation of the PI3K/AKT/mTOR signaling pathway.
Acquired Resistance to First-Line Osimertinib Is Heterogeneous in EGFR-Mutant Advanced Non-Small Cell Lung Cancer
[Scientific Reports] Investigators showed that acquired resistance to first-line osimertinib in EGFR-mutant lung cancer arises through diverse mechanisms, underscoring the need for molecular profiling to guide subsequent therapy.
Extracellular Vesicles As Diagnostic and Prognostic Biomarkers in Non-Small Cell Lung Cancer
[Expert Review of Molecular Diagnostics] Scientists highlight extracellular vesicles as promising liquid biopsy biomarkers for non-small cell lung cancer, with potential to improve early diagnosis, prognosis, and personalized treatment monitoring.
Targeting the Senescence‒Autophagy Axis via p16INK4a Inhibition Alleviates Pulmonary Fibrosis
[Signal Transduction and Targeted Therapy] Researchers identified p16 as a mechanistically defined regulator of fibrosis progression and suggested that modulating this axis may offer new opportunities for therapeutic intervention in idiopathic pulmonary fibrosis.
Z226407860 Attenuates HDM-Induced Airway Epithelial Injury and ROS Accumulation via RBX1 Inhibition
[Bioorganic Chemistry] Investigators identified RING-box protein 1 (RBX1) as a critical regulator of airway epithelial injury, whose expression is markedly elevated in asthma.
Plasma Signals of Lung Tumor Promotion for Molecular Cancer Prevention
[Cell] Scientists addressed the origins of the signature, first determining that basal, club, neuroendocrine, and AT2 epithelial lineages were competent to form EGFR-driven lung adenocarcinoma, with conserved keratin 8+ alveolar intermediate cell-like states observed within the alveolar niche.
High-Throughput Screening Identifies a Critical Role of the SPOP-PABPC1 Axis in Lung Adenocarcinoma Progression
[Proceedings of the National Academy of Sciences of the United States of America] Through an integrated screening combining bioinformatics, transcriptomics, and clinical prognostic analysis, the authors identified E3 ubiquitin ligase SPOP as a key tumor suppressor in lung adenocarcinoma.
Carnosol Targets KAT2B/H3K18la Axis to Regulate Histone Lactylation and Inhibit Proliferation of Lung Cancer Cells
[Biochemical Pharmacology] Using multiple experimental approaches, including the Cell Counting Kit-8 assay, colony formation assay, flow cytometry, RNA sequencing, and Western blot analysis, investigators systematically evaluated the in vitro effects of Carnosol on lung cells
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
