Hotspot Mutant p53-R273H Inhibits KLF6 Expression to Promote Cell Migration and Tumor Metastasis

Scientists revealed an important role for EGFR–AKT–FOXO1–KLF6–E-cadherin axis in mutant p53-induced cell migration and tumor metastasis.
[Cell Death & Disease]
Sun, S., Chen, H., Sun, L., Wang, M., Wu, X., & Xiao, Z.-X. J. (2020). Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis. Cell Death & Disease, 11(7), 1–9. https://doi.org/10.1038/s41419-020-02814-1 Cite
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miR-135a Inhibits Non-Small Cell Lung Cancer Progression by Suppressing RAB1B Expression and the RAS Pathway

Researchers showed that miR-135a was aberrantly downregulated in non-small cell lung cancer (NSCLC) cells in comparison with normal bronchial epithelial cells, and the expression of miR-135a inhibited proliferation, invasion and metastasis of NSCLC cells in vitro.
[Aging]
Aging | MiR-135a inhibits non-small cell lung cancer progression by suppressing RAB1B expression and the RAS pathway - Full Text. (n.d.). Retrieved July 31, 2020, from https://www.aging-us.com/article/103494/text Cite
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LINC00324 Affects Non-Small Cell Lung Cancer Cell Proliferation and Invasion through Regulation of the miR-139-5p/IGF1R Axis

Scientists demonstrated whether LINC00324 participates in non-small cell lung cancer pathogenesis through other molecular mechanism.
[Molecular and Cellular Biochemistry]
Zhang, M., Lin, B., Liu, Y., Huang, T., Chen, M., Lian, D., Deng, S., & Zhuang, C. (2020). LINC00324 affects non-small cell lung cancer cell proliferation and invasion through regulation of the miR-139-5p/IGF1R axis. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03819-2 Cite
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Comprehensive Analysis of Circular RNA Expression Profiles in Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines

Two cisplatin-resistant non-small cell lung cancer cell lines were established by gradually increasing concentrations of cisplatin in the media. The resulting cell lines possessed high resistance to cisplatin and strong proliferation, migration, and colony formation abilities compared to the parental cells.
[Acta Biochimica Et Biophysica Sinica]
Song, L., Cui, Z., & Guo, X. (n.d.). Comprehensive analysis of circular RNA expression profiles in cisplatin-resistant non-small cell lung cancer cell lines. Acta Biochimica et Biophysica Sinica. https://doi.org/10.1093/abbs/gmaa085 Cite
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Opportunities and Obstacles of Targeted Therapy and Immunotherapy in Small Cell Lung Cancer

The authors review the molecular biology characteristics of small cell lung cancer (SCLC) and discuss the opportunities and obstacles of the current therapy for SCLC patients.
[Journal of Drug Targeting]
Yu, L., Lai, Q., Gou, L., Feng, J., & Yang, J. (2020). Opportunities and obstacles of targeted therapy and immunotherapy in small cell lung cancer. Journal of Drug Targeting, 0(0), 1–11. https://doi.org/10.1080/1061186X.2020.1797050 Cite
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Pulmonary Toxicity of Systemic Lung Cancer Therapy

Pulmonary toxicity from taxanes presents as an ILD‐type reaction characterized by increasing dyspnoea, dry cough, fever and bilateral pulmonary interstitial infiltrates.
[Respirology]
Long, K., & Suresh, K. (n.d.). Pulmonary toxicity of systemic lung cancer therapy. Respirology, n/a(n/a). https://doi.org/10.1111/resp.13915 Cite
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Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
Gu, C., Zhang, Q., Ni, D., Xiao, Q.-F., Cao, L.-F., Fei, C.-Y., Ying, Y., Li, N., & Tao, F. (2020). Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. COPD: Journal of Chronic Obstructive Pulmonary Disease, 0(0), 1–8. https://doi.org/10.1080/15412555.2020.1797657 Cite
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A Single-Cell Atlas of the Human Healthy Airways

Scientists explored the cellular heterogeneity of the human airway epithelium in 10 healthy living volunteers by single-cell RNA profiling. 77,969 cells were collected at 35 distinct locations, from the nose to the 12th division of the airway tree.
[American Journal of Respiratory and Critical Care Medicine]
Deprez, M., Zaragosi, L.-E., Truchi, M., Becavin, C., Ruiz García, S., Arguel, M.-J., Plaisant, M., Magnone, V., Lebrigand, K., Abelanet, S., Brau, F., Paquet, A., Pe’er, D., Marquette, C.-H., Leroy, S., & Barbry, P. (2020). A Single-cell Atlas of the Human Healthy Airways. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201911-2199OC Cite
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Impaired AKT Signaling and Lung Tumorigenesis by PIERCE1 Ablation in KRAS-Mutant Non-Small Cell Lung Cancer

Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers.
[Oncogene]
Roh, J., Lee, J., Sung, Y.-H., Oh, J., Hyeon, D. Y., Kim, Y., Lee, S., Devkota, S., Kim, H. J., Park, B., Nam, T., Song, Y., Kim, Y., Hwang, D., & Lee, H.-W. (2020). Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer. Oncogene, 1–12. https://doi.org/10.1038/s41388-020-01399-5 Cite
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Glycogen Synthase Kinase‐3β Promotes Radiation‐Induced Lung Fibrosis by Regulating β‐Catenin/lin28 Signaling Network to Determine Type II Alveolar Stem Cell Transdifferentiation State

Scientists explored the expressions of cell phenotype markers and differentiation regulators in isolated type II alveolar epithelial stem cells (AEC II) to analyze the correlation between GSK‐3β/TGF‐β1/β‐catenin signaling pathway, lin28/let‐7 balance, and AEC II phenotypes at different injury phases following irradiation.
[FASEB Journal]
Zhang, T., Zhou, J., Yue, H., Du, C., Xiao, Z., Zhao, W., Li, N., Wang, X., Liu, X., Li, Y., Geng, X., Zhang, Y., Li, L., & Tian, J. (n.d.). Glycogen synthase kinase-3β promotes radiation-induced lung fibrosis by regulating β-catenin/lin28 signaling network to determine type II alveolar stem cell transdifferentiation state. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202001518 Cite
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Ubiquilin Proteins Regulate EGFR Levels and Activity in Lung Adenocarcinoma Cells

The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
Kurlawala, Z., Saurabh, K., Dunaway, R., Shah, P. P., Siskind, L. J., & Beverly, L. J. (n.d.). Ubiquilin proteins regulate EGFR levels and activity in lung adenocarcinoma cells. Journal of Cellular Biochemistry, n/a(n/a). https://doi.org/10.1002/jcb.29830 Cite
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Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
Cheng, J., Lin, M., Chu, M., Gong, L., Bi, Y., & Zhao, Y. (2020). Emerging role of FBXO22 in carcinogenesis. Cell Death Discovery, 6(1), 1–7. https://doi.org/10.1038/s41420-020-00303-0 Cite
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