Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

Building a Human Lung from Pluripotent Stem Cells to Model Respiratory Viral Infections

[Respiratory Research] The authors propose a guideline using iPSCs to create all the disease-relevant cell types. iPSCs can be differentiated into lung epithelium, innate immune cells, endothelial cells, and fibroblasts at a large scale, recapitulating in vivo functions and providing genetic tractability.

Mendoza, Weiss Receive $2.6 Million Grant to Study Biomechanics of Lung Tumors

[Huntsman Cancer Institute] Dr. Michelle Mendoza and Dr. Jeffrey Weissare the recipients of a $2.6 million grant from the National Institutes of Health to research how tension in lung tissue affects the growth and distribution of tumors.

Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small-Cell Lung Cancer: The Phase II Baltic Study

[Clinical Cancer Research] The Phase II, multiarm, signal-searching BALTIC study assessed novel treatment combinations for platinum-refractory/resistant extensive-stage small-cell lung cancer.

PRMT1 Promotes Warburg Effect by Regulating the PKM2/PKM1 Ratio in Non-Small Cell Lung Cancer

[Cell Death & Disease] Researchers discovered that protein arginine methyltransferase 1 (PRMT1) was highly expressed under conditions of glucose sufficiency. PRMT1 induced an increase in the PKM2/PKM1 ratio through upregulation of PTBP1, in turn, promoting aerobic glycolysis in NSCLC.

NOP2 Facilitates EZH2-Mediated Epithelial–Mesenchymal Transition by Enhancing EZH2 mRNA Stability via m5C Methylation in Lung Cancer Progression

[Cell Death & Disease] Lentivirus-mediated overexpression of NOP2 in vitro resulted in enhanced migration and invasion capabilities of lung cancer cells, while in vivo experiments demonstrated its ability to promote the growth and metastasis of xenograft tumors.

A Fibroblast-Dependent TGFβ1/sFRP2 Noncanonical Wnt Signaling Axis Promotes Epithelial Metaplasia in Idiopathic Pulmonary Fibrosis

[Journal of Clinical Investigation] Scientists administered the fibroblast-selective TGFβ1 signaling inhibitor, epigallocatechin gallate, to interstitial lung disease patients undergoing diagnostic lung biopsy and conducted single-cell RNA sequencing on spare tissue.

SHR-A1811 (Antibody-Drug Conjugate) in Advanced HER2-Mutant Non-Small Cell Lung Cancer: A Multicenter, Open-Label, Phase I/II Study

[Signal Transduction and Targeted Therapy] A dose-escalation and expansion, phase I/II study was conducted to assess the novel antibody-drug conjugate SHR-A1811 in pretreated HER2-altered advanced NSCLC.

The Impact of Tertiary Lymphoid Structures on Tumor Prognosis and the Immune Microenvironment in Non-Small Cell Lung Cancer

[Scientific Reports] Scientists accessed The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases to obtain mRNA sequencing data and clinical information as the TCGA cohort, and used our own sample of 53 advanced non-small cell lung cancer as a study cohort.

Alveolar Fibroblast Lineage Orchestrates Lung Inflammation and Fibrosis

[Nature] Scientists showed that lung-specialized alveolar fibroblasts took on multiple molecular states with distinct roles in facilitating responses to fibrotic lung injury.

Medical College of Wisconsin Set to Lead Key Initiative as Part of EDA Tech Hub Phase II Funding

[Wisconsin BioHealth Tech Hub (PR Newswire)] The US Economic Development Administration has awarded $49 million to the Wisconsin BioHealth Tech Hub, a transformative initiative to make Wisconsin a national leader in personalized medicine by accelerating biomedical innovation, growing jobs, and bringing new products to market.

Anti-CCL2 Therapy Reduces Oxygen Toxicity to the Immature Lung

[Cell Death Discovery] Researchers studied macrophage and neutrophil profiles in tracheal aspirates of preterm infants less than 29 weeks´ gestation requiring mechanical ventilation.

Identification of a Combined Hypoxia and Lactate Metabolism Prognostic Signature in Lung Adenocarcinoma

[BMC Pulmonary Medicine] Transcriptomic sequencing data and patient clinical information specific to lung adenocarcinoma were obtained from comprehensive repositories of The Cancer Genome Atlas and Gene Expression Omnibus.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!