DRP1 Promotes Lactate Utilization in KRAS‐Mutant Non‐Small Cell Lung Cancer Cells

Scientists developed a lactate‐dependent cell proliferation assay and found that dynamin‐related protein (DRP1), which was highly expressed in KRAS‐mutant non‐small cell lung cancer (NSCLC), was required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.
[Cancer Science]
Hu, M., Zhao, Y., Cao, Y., Tang, Q., Feng, Z., Ni, J., & Zhou, X. (n.d.). DRP1 promotes lactate utilization in KRAS-mutant non-small cell lung cancer cells. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14603 Cite
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High Expression of NEK2 Promotes Lung Cancer Progression and Drug Resistance and Is Regulated by Mutant EGFR

Elevated never in mitosis gene A-related kinase 2 level promoted the rapid cell cycle progression and favors the rapid proliferation of epidermal growth factor receptor-mutant non-small cell lung cancer cells.
[Molecular and Cellular Biochemistry]
Chen, C., Peng, S., Li, P., Ma, L., & Gan, X. (2020). High expression of NEK2 promotes lung cancer progression and drug resistance and is regulated by mutant EGFR. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03854-z Cite
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Complement and Tissue Factor-Enriched Neutrophil Extracellular Traps Are Key Drivers in COVID-19 Immunothrombosis

The authors investigated how complement interacted with the platelet/neutrophil extracellular traps (NETS)/thrombin axis, using COVID-19 specimens, cell-based inhibition studies and NETs/human aortic endothelial cell co-cultures.
[Journal of Clinical Investigation]
Skendros, P., Mitsios, A., Chrysanthopoulou, A., Mastellos, D. C., Metallidis, S., Rafailidis, P., Ntinopoulou, M., Sertaridou, E., Tsironidou, V., Tsigalou, C., Tektonidou, M. G., Konstantinidis, T., Papagoras, C., Mitroulis, I., Germanidis, G., Lambris, J. D., & Ritis, K. (2020). Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI141374 Cite
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Inhibition of Mitophagy Drives Macrophage Activation and Anti-bacterial Defense during Sepsis

Scientists showed that lipopolysaccharide in combination with IFNγ, inhibited PINK1-dependent mitophagy in macrophages through a STAT1-dependent activation of the inflammatory caspases 1 and 11.
[Journal of Clinical Investigation]
Patoli, D., Mignotte, F., Deckert, V., Dusuel, A., Dumont, A., Rieu, A., Jalil, A., Dongen, K. V., Bourgeois, T., Gautier, T., Magnani, C., Guern, N. L., Mandard, S., Bastin, J., Djouadi, F., Schaeffer, C., Guillaumot, N., Narce, M., Nguyen, M., … Thomas, C. (2020). Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI130996 Cite
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Immune-Mobilising Monoclonal T Cell Receptors Mediate Specific and Rapid Elimination of Hepatitis B-Infected Cells

The ability of immune mobilising monoclonal T cell receptors Against Virus-envelope to activate and redirect polyclonal T cells towards cells containing integrated HBV and cells infected with hepatitis B virus was assessed using cytokine secretion assays and imaging‐based killing assays.
[Hepatology]
Fergusson, J. R., Wallace, Z., Connolly, M. M., Woon, A. P., Suckling, R. J., Hine, D. W., Barber, C., Bunjobpol, W., Choi, B.-S., Crespillo, S., Dembek, M., Dieckmann, N., Donoso, J., Godinho, L. F., Grant, T., Howe, D., McCully, M. L., Perot, C., Sarkar, A., … Knox, A. (n.d.). Immune-mobilising monoclonal T cell receptors mediate specific and rapid elimination of Hepatitis B-infected cells. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31503 Cite
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Cerebrospinal Fluid Features in SARS-CoV-2 RT-PCR Positive Patients

Scientists observed neither SARS-CoV-2 RNA in the cerebrospinal fluid, nor intrathecal IgG synthesis, but did observe signs of blood-brain barrier disruption.
[Clinical infectious Diseases]
Bellon, M., Schweblin, C., Lambeng, N., Cherpillod, P., Vazquez, J., Lalive, P. H., Schibler, M., & Deffert, C. (n.d.). Cerebrospinal fluid features in SARS-CoV-2 RT-PCR positive patients. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1165 Cite
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Neutrophil Extracellular Traps Amplify Neutrophil Recruitment and Inflammation in Neutrophilic Asthma by Stimulating the Airway Epithelial Cells to Activate the TLR4/NF-κB Pathway and Secrete Chemokines

Formation of neutrophil extracellular traps (NETs) and neutrophil swarming was seen in a mouse model of neutrophilic asthma. Additionally, NETs were found to stimulate airway cells to express CXCL1, CXCL2, and CXCL8 via the TLR4/NF-κB pathway, which recruits neutrophils to the inflammation site.
[Aging]
Aging | Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines - Full Text. (n.d.). Retrieved August 7, 2020, from https://www.aging-us.com/article/5f2427ad6c2ca900075aeb68/text Cite
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Inhibitory Effect of MicroRNA-608 on Lung Cancer Cell Proliferation, Migration, and Invasion by Targeting BRD4 through the JAK2/STAT3 Pathway

Investigators determined the fundamental mechanism of microRNA-608 in the development of lung cancer.
[Bosnian Journal of Basic Medical Sciences]
Xu, W., Sun, D., Wang, Y., Zheng, X., Li, Y., Xia, Y., & Teng, Y. (2020). Inhibitory effect of microRNA-608 on lung cancer cell proliferation, migration, and invasion by targeting BRD4 through the JAK2/STAT3 pathway. Bosnian Journal of Basic Medical Sciences, 20(3), 347–356. https://doi.org/10.17305/bjbms.2019.4216 Cite
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Daiichi Sankyo Announces Clinical Trial Collaboration with AstraZeneca to Evaluate Patritumab Deruxtecan (U3-1402) in Combination with TAGRISSO in EGFR-Mutated Non-Small Cell Lung Cancer

Daiichi Sankyo Company, Limited announced that it has entered into a clinical trial collaboration with AstraZeneca to evaluate the combination of patritumab deruxtecan, a HER3 directed DXd antibody drug conjugate, and TAGRISSO, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with EGFR-mutated advanced or metastatic non-small cell lung cancer.
[Daiichi Sankyo Company, Limited]
Press Release

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Inhibition of PIKfyve Kinase Prevents Infection by Zaire Ebolavirus and SARS-CoV-2

Scientists describe potent inhibitory effects on content release and infection by chimeric vesicular stomatitis virus containing the envelope proteins of Zaire ebolavirus or SARS-CoV-2 elicited by Apilimod and Vacuolin-1, small-molecule inhibitors of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve.
[Proceedings of the National Academy of Sciences of the United States of America]
Kang, Y.-L., Chou, Y., Rothlauf, P. W., Liu, Z., Soh, T. K., Cureton, D., Case, J. B., Chen, R. E., Diamond, M. S., Whelan, S. P. J., & Kirchhausen, T. (2020). Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2007837117 Cite
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Novel Multiparameter Correlates of Coxiella burnetii Infection and Vaccination Identified by Longitudinal Deep Immune Profiling

Using a vaccine-challenge model in HLA-DR transgenic mice, investigators demonstrated significant alterations in circulating T-cell and innate immune populations that distinguished vaccinated from naïve mice within ten days, and persisted until at least 35 days post-vaccination.
[Scientific Reports]
Reeves, P. M., Raju Paul, S., Baeten, L., Korek, S. E., Yi, Y., Hess, J., Sobell, D., Scholzen, A., Garritsen, A., De Groot, A. S., Moise, L., Brauns, T., Bowen, R., Sluder, A. E., & Poznansky, M. C. (2020). Novel multiparameter correlates of Coxiella burnetii infection and vaccination identified by longitudinal deep immune profiling. Scientific Reports, 10(1), 13311. https://doi.org/10.1038/s41598-020-69327-x Cite
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Quantitative Evaluation of Protective Antibody Response Induced by Hepatitis E Vaccine in Humans

Vaccine-induced antibodies exhibited a high degree of clonal diversity, recognized five conformational antigenic sites of the genotype 1 HEV p239 antigen, and cross-reacted with other genotypes.
[Nature Communications]
Wen, G.-P., He, L., Tang, Z.-M., Wang, S.-L., Zhang, X., Chen, Y.-Z., Lin, X., Liu, C., Chen, J.-X., Ying, D., Chen, Z.-H., Wang, Y.-B., Luo, W.-X., Huang, S.-J., Li, S.-W., Zhang, J., Zheng, Z.-Z., Zhu, J., & Xia, N.-S. (2020). Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans. Nature Communications, 11(1), 3971. https://doi.org/10.1038/s41467-020-17737-w Cite
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