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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Pulmonary Fibroblast Activation during Aspergillus Fumigatus Infection Enhances Lung Defense via Immunomodulation and Tissue Remodeling
[Nature Communications] Researchers employed cell lineage tracing, targeted cell ablation, and single-cell RNA sequencing to monitor fibroblast dynamics upon exposure to Aspergillus fumigatus in immunocompetent and immunosuppressed hosts.
Discovery and Evaluation of a PROTAC Degrader Targeting SAMHD1 for the Treatment of Pulmonary Fibrosis
[Journal of Medicinal Chemistry] Scientists reported the discovery of NP12, the first SAMHD1 degrader with intracellular activity. In a bleomycin-induced pulmonary fibrosis mouse model, NP12 delayed pulmonary fibrosis progression and exerted a protective effect on lung tissue.
BMX Inhibition Overcomes Small Cell Lung Cancer Chemoresistance by Stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 Axis
[Signal Transduction and Targeted Therapy] Investigators revealed that the BMX (bone marrow tyrosine kinase on chromosome X)-E2F1 (E2F transcription factor 1) axis is a pivotal regulator of chemoresistance in small cell lung cancer.
KLF5 Activation Promotes Malignant Transformation to Drive Development of Lung Squamous Cell Carcinoma
[Cancer Research] The authors used genetically engineered organoids to identify the function of KLF5 in tumorigenesis of multiple endodermal epithelial cancers.
Identification of Pinostilbene As a Natural STING Agonist That Triggers FTH1 Degradation via K48-Ubiquitination to Induce Ferroptosis in Non-Small Cell Lung Cancer
[Redox Biology] Researchers identified and characterized novel Stimulator of Interferon Genes (STING) agonist compounds with enhanced therapeutic potential for NSCLC.
A tRNA-Derived Fragment tRF3019a Promotes LUAD Metastasis by Stabilizing hnRNPK and Enhancing MYH11 Expression
[Cellular & Molecular Biology Letters] Investigators found that tRF3019a promoted lung adenocarcinoma progression and metastasis by stabilizing hnRNPK and enhancing hnRNPK-associated transcriptional regulation of myosin heavy chain 11 (MYH11).
EIF4A3-Induced circUBAC2 Promotes Lung Cancer Progression via Regulation of the Hippo Signaling Pathway
[Cellular & Molecular Biology Letters] The authors explored the oncogenic role of circUBAC2 in lung adenocarcinoma (LUAD) progression and found that circUBAC2 drives LUAD progression via YAP signaling.
β-Arrestin and Receptor Tyrosine Kinases in Non-Small Cell Lung Cancer: A Comprehensive Review
[International Journal of Biological Macromolecules] Scientists identify β-arrestin and receptor tyrosine kinases as crucial players in NSCLC progression, metastasis, and treatment resistance.
Vertex Announces US FDA Approval for Label Extensions of ALYFTREK® and TRIKAFTA®, Expanding Availability of These Medicines to ~95% of All People With CF...
[Vertex Pharmaceuticals Incorporated] Vertex Pharmaceuticals Incorporated announced the US FDA has approved expanded use of ALYFTREK® for the treatment of people with cystic fibrosis ages 6 and older with a variant in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is either responsive based on clinical and/or in vitro data or results in production of CFTR protein.
Autocrine SFRP2 (Secreted Frizzled Related Protein 2) Enhances Lung Myofibroblast Fibrogenic Activity by Suppressing PINK1-Mediated Mitophagy Initiation
[Autophagy] Using single-cell RNA sequencing, researchers identified SFRP2 as a critical mediator of profibrotic myofibroblasts in idiopathic pulmonary fibrosis lungs.
E2A Selectively Regulates TGF-β-Induced Apoptosis in KRAS-Mutant Non-Small Cell Lung Cancer
[Molecular Oncology] Investigators identified the transcription factor E2A as a critical mediator of resistance to transforming growth factor-β (TGF-β)-induced apoptosis in mutant KRAS–driven NSCLC.
TNIK Overexpression Is Sufficient for Chemoradiation Resistance in Limited-Stage Small Cell Lung Cancer
[Molecular Cancer Therapeutics] Researchers used patient-derived xenografts to model small cell lung cancer chemoradiation resistance and identified chemoradiation resistance candidate genes using RNA sequencing.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
