Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death and in most cases it is often diagnosed at an advanced stage. Many genetic and microenvironmental factors are able to modify the cell cycle inducing carcinogenesis and tumor growth.
Scientists exposed the human alveolar A549 cell line to 0, 200, and 500 μg/mL quartz particles for 24 hours and used gas chromatography–mass spectrometry to measure the volatile metabolites in the headspace air of cells.
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The authors identified a long noncoding RNA LINC00857 that might regulate radio-sensitivity of lung adenocarcinoma cells.
[Molecular Therapy-Nucleic Acids]
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Investigators showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.
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The Janssen Pharmaceutical Companies of Johnson & Johnson announced interim results from the CHRYSALIS study, evaluating amivantamab, a fully human bispecific antibody that targets epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition factor mutations, in combination with the third-generation EGFR tyrosine kinase inhibitor lazertinib in patients with non-small cell lung cancer with EGFR exon 19 deletions or L858R mutations.
[Janssen Global Services, LLC]
Investigators found that miR-196b-5p promoted lung cancer cell proliferation and colony formation by directly targeting tumor suppressor, FAS.
[Cell Death & Disease]
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Huang, X., Xiao, S., Zhu, X., Yu, Y., Cao, M., Zhang, X., Li, S., Zhu, W., Wu, F., Zheng, X., Jin, L., Xie, C., Huang, X., Zou, P., Li, X., & Cui, R. (2020). miR-196b-5p -mediated downregulation of FAS promotes NSCLC progression by activating IL6-STAT3 signaling. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02997-7 Cite
Researchers characterized the contribution of one of the identified genes, MBIP, towards driving tumor invasion and metastasis. They demonstrated that expression of MBIP significantly enhanced the cellular proliferation, migration and invasion of NSCLC cells in vitro and metastasis in vivo.
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CB11 caused cell death via reactive oxygen species-mediated ATM-p53-GADD45α signaling in human non-small-cell lung cancer cells, and diphenyleneiodonium, an NADPH oxidase inhibitor, decreases cell death by inhibiting CB11-mediated ATM signaling.
[British Journal of Cancer]
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A tumor xenograft mouse model was used to determine role of extracellular vesicles-microRNA-130b-3p and its target FOXO3 in lung cancer progression in vivo.
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Guo, Q., Yan, J., Song, T., Zhong, C., Kuang, J., Mo, Y., Tan, J., Li, D., Sui, Z., Cai, K., & Zhang, J. (2020). microRNA-130b-3p Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.09.005 Cite
The authors investigated the anti-tumor functions and the feasible molecular basis of nitidine chloride in NSCLC cells.
[Cell Death Discovery]
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Scientists analyzed the anticancer potential of hmxbato against lung tumor cells, as well as the partial death mechanisms involved.
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Costa, M. S., Gonçalves, Y. G., Borges, B. C., Silva, M. J. B., Amstalden, M. K., Costa, T. R., Antunes, L. M. G., Rodrigues, R. S., Rodrigues, V. de M., de Faria Franca, E., Zoia, M. A. P., de Araújo, T. G., Goulart, L. R., Von Poelhsitz, G., & Yoneyama, K. A. G. (2020). Ruthenium (II) complex cis -[Ru II (ŋ 2 -O 2 CC 7 H 7 O 2 )(dppm) 2 ]PF 6 -hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity. Scientific Reports, 10(1), 15410. https://doi.org/10.1038/s41598-020-72420-w Cite