Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

Astrotech Corporation Announces Advancement in Detection of Lung Infections The BreathTest-1000

[Astrotech Corporation] Astrotech Corporation subsidiary, BreathTech Corporation announced that, based on analysis of data from testing of breath samples procured during our library development, the BreathTest-1000TM lung disease screening instrument can clearly distinguish between infected and healthy breath samples.

Alveolar Cell Fate Selection and Lifelong Maintenance of AT2 Cells by FGF Signaling

[Nature Communications] Researchers demonstrated that alveolar cell fate specification was, in fact, dictated by a classic growth factor signal, the same FGF signaling pathway that controlled the earlier steps of airway budding and branching and also initiated subsequent budding.

PEAR1 Regulates Expansion of Activated Fibroblasts and Deposition of Extracellular Matrix in Pulmonary Fibrosis

[Nature Communications] Scientists presented that platelet endothelial aggregation receptor 1 (PEAR1) in fibroblasts may serve as a target for pulmonary fibrosis therapy.

Role of Secondary Organic Matter on Soot Particle Toxicity in Reconstituted Human Bronchial Epithelia Exposed at the Air–Liquid Interface

[Environmental Science & Technology] The authors combined the generation of well-controlled and chemically defined synthetic reference aerosols with state-of-the-art cell cultures, particle exposure, and analysis to identify specific aerosol properties adversely affecting respiratory health.

Emodin Inhibiting Epithelial-Mesenchymal Transition in Pulmonary Fibrosis through the C-MYC/miR-182-5p/ZEB2 Axis

[Phytotherapy Research] Investigators demonstrated that Emodin attenuated pulmonary fibrosis induced by bleomycin in mice, and inhibited epithelial-mesenchymal transition, meanwhile downregulated c-MYC, upregulated miR-182-5p, and downregulated ZEB2 in vitro and in vivo.

Effective-Component Compatibility of Bufei Yishen Formula III Ameliorated COPD by Improving Airway Epithelial Cell Senescence by Promoting Mitophagy via the NRF2/PINK1 Pathway

[BMC Pulmonary Medicine] Scientists investigated the mechanisms of effective-component compatibility of Bufei Yishen formula III in chronic obstructive pulmonary disease rats from the aspect of airway epithelial cell senescence.

MET Kinase Inhibitor Reverses Resistance to Entrectinib Induced by Hepatocyte Growth Factor in Tumors with NTRK1 or ROS1 Rearrangements

[Cancer Medicine] Researchers investigated whether growth factors that may be produced by the microenvironment affect sensitivity of NTRK1-rearranged colon cancer KM12SM cells and ROS1-rearranged NSCLC HCC78 cells to entrectinib both in vitro and in vivo.

Anwuligan Inhibits the Progression of Non-small Cell Lung Cancer via Let-7c-3p/PI3K/AKT/mTOR Axis

[Cancer Medicine] Scientists found that anwuligan inhibited the growth and metastasis of NSCLC cells in vivo and in vitro by upregulating the expression of let-7c-3p, which could regulate the PI3K/AKT/mTOR signaling pathway.

CD47 Blockade Improves the Therapeutic Effect of Osimertinib in Non-small Cell Lung Cancer

[Frontiers of Medicine] Investigators explored a rational combination strategy for enhancing the osimertinib efficacy and found that it induced higher CD47 expression, an important anti-phagocytic immune checkpoint, via the NF-κB pathway.

Emerging Role of Chemokines in Small Cell Lung Cancer: Road Signs for Metastasis, Heterogeneity, and Immune Response

[Seminars in Cancer Biology] The authors summarize and highlight recent findings that establish the role of chemokines in SCLC growth and metastasis, and sophisticated intratumor heterogeneity.

Molecular Mechanisms of Cell Death in Bronchopulmonary Dysplasia

[Apoptosis] Investigators elucidate the mechanism of bronchopulmonary dysplasia (BPD), focusing on the multiple types of programmed cell death in BPD and their molecular mechanisms, which are mainly based on experimental results obtained in rodents.

Mitophagy Bridges DNA Sensing With Metabolic Adaption To Expand Lung Cancer Stem-Like Cells

[EMBO Reports] The authors identified hypermitophagy as a feature of human lung CSCs, promoting metabolic adaption via the Notch1-AMPK axis to drive CSC expansion.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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