Expression and Role of p16 and GLUT1 in Malignant Diseases and Lung Cancer: A Review

Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death and in most cases it is often diagnosed at an advanced stage. Many genetic and microenvironmental factors are able to modify the cell cycle inducing carcinogenesis and tumor growth.
[Thoracic Cancer]
Pezzuto, A., D’Ascanio, M., Ricci, A., Pagliuca, A., & Carico, E. (n.d.). Expression and role of p16 and GLUT1 in malignant diseases and lung cancer: A review. Thoracic Cancer, n/a(n/a). https://doi.org/10.1111/1759-7714.13651 Cite
Full Article
Bookmark

No account yet? Register

0
Share

A Novel Lung Alveolar Cell Model for Exploring Volatile Biomarkers of Particle-Induced Lung Injury

Scientists exposed the human alveolar A549 cell line to 0, 200, and 500 μg/mL quartz particles for 24 hours and used gas chromatography–mass spectrometry to measure the volatile metabolites in the headspace air of cells.
[Scientific Reports]
Chuang, H.-C., Tsai, S.-W., Shie, R.-H., Lu, Y.-C., Song, S.-R., Huang, S.-H., Peng, H.-Y., & Yang, H.-Y. (2020). A novel lung alveolar cell model for exploring volatile biomarkers of particle-induced lung injury. Scientific Reports, 10(1), 15700. https://doi.org/10.1038/s41598-020-72825-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Silencing of lncRNA LINC00857 Enhances BIRC5-Dependent Radio-Sensitivity of Lung Adenocarcinoma Cells by Recruiting NFκB1

The authors identified a long noncoding RNA LINC00857 that might regulate radio-sensitivity of lung adenocarcinoma cells.
[Molecular Therapy-Nucleic Acids]
Han, F., Yang, S., Wang, W., Huang, X., Huang, D., & Chen, S. (2020). Silencing of lncRNA LINC00857 enhances BIRC5-dependent radio-sensitivity of lung adenocarcinoma cells by recruiting NFκB1. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.020 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Matrix Metalloprotease-7 Mediates Nucleolar Assembly & Intra-Nucleolar Cleaving p53 in Gefitinib Resistant Cancer Stem Cells

Investigators showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.
[iScience]
Yu, W.-H., Wu, E., Li, Y., Hou, H.-H., Yu, S. C., Huang, P.-T., Kuo, W.-H., Qi, D., & Yu, C.-J. (2020). Matrix metalloprotease-7 mediates nucleolar assembly & intra-nucleolar cleaving p53 in gefitinib resistant cancer stem cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101600 Cite
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Janssen Presents Findings from Global, Multi-Center Trial Examining Amivantamab in Combination with Lazertinib in Patients with EGFR-Mutated Non-Small Cell Lung Cancer

The Janssen Pharmaceutical Companies of Johnson & Johnson announced interim results from the CHRYSALIS study, evaluating amivantamab, a fully human bispecific antibody that targets epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition factor mutations, in combination with the third-generation EGFR tyrosine kinase inhibitor lazertinib in patients with non-small cell lung cancer with EGFR exon 19 deletions or L858R mutations.
[Janssen Global Services, LLC]
Press Release
Bookmark

No account yet? Register

0
Share

miR-196b-5p-Mediated Downregulation of FAS Promotes NSCLC Progression by Activating IL6-STAT3 Signaling

Investigators found that miR-196b-5p promoted lung cancer cell proliferation and colony formation by directly targeting tumor suppressor, FAS.
[Cell Death & Disease]
Huang, X., Xiao, S., Zhu, X., Yu, Y., Cao, M., Zhang, X., Li, S., Zhu, W., Wu, F., Zheng, X., Jin, L., Xie, C., Huang, X., Zou, P., Li, X., & Cui, R. (2020). miR-196b-5p -mediated downregulation of FAS promotes NSCLC progression by activating IL6-STAT3 signaling. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02997-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

MBIP (MAP3K12 Binding Inhibitory Protein) Drives NSCLC Metastasis by JNK-Dependent Activation of MMPs

Researchers characterized the contribution of one of the identified genes, MBIP, towards driving tumor invasion and metastasis. They demonstrated that expression of MBIP significantly enhanced the cellular proliferation, migration and invasion of NSCLC cells in vitro and metastasis in vivo.
[Oncogene]
Ochieng, J. K., Kundu, S. T., Bajaj, R., Leticia Rodriguez, B., Fradette, J. J., & Gibbons, D. L. (2020). MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01463-0 Cite
Abstract
Bookmark

No account yet? Register

0
Share

CB11, a Novel Purine-Based PPARɣ Ligand, Overcomes Radio-Resistance by Regulating ATM Signaling and EMT in Human Non-Small-Cell Lung Cancer Cells

CB11 caused cell death via reactive oxygen species-mediated ATM-p53-GADD45α signaling in human non-small-cell lung cancer cells, and diphenyleneiodonium, an NADPH oxidase inhibitor, decreases cell death by inhibiting CB11-mediated ATM signaling.
[British Journal of Cancer]
Kim, T. W., Hong, D.-W., Park, J. W., & Hong, S. H. (2020). CB11, a novel purine-based PPARɣ ligand, overcomes radio-resistance by regulating ATM signalling and EMT in human non-small-cell lung cancer cells. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01088-w Cite
Abstract
Bookmark

No account yet? Register

0
Share

microRNA-130b-3p Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis

A tumor xenograft mouse model was used to determine role of extracellular vesicles-microRNA-130b-3p and its target FOXO3 in lung cancer progression in vivo.
[Molecular Therapy-Oncolytics]
Guo, Q., Yan, J., Song, T., Zhong, C., Kuang, J., Mo, Y., Tan, J., Li, D., Sui, Z., Cai, K., & Zhang, J. (2020). microRNA-130b-3p Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.09.005 Cite
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Nitidine Chloride Possesses Anticancer Property in Lung Cancer Cells through Activating Hippo Signaling Pathway

The authors investigated the anti-tumor functions and the feasible molecular basis of nitidine chloride in NSCLC cells.
[Cell Death Discovery]
Zhang, J., Wu, L., Lian, C., Lian, S., Bao, S., Zhang, J., Wang, P., Ma, J., & Li, Y. (2020). Nitidine chloride possesses anticancer property in lung cancer cells through activating Hippo signaling pathway. Cell Death Discovery, 6(1), 1–9. https://doi.org/10.1038/s41420-020-00326-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Ruthenium (II) Complex cis-[RuII2-O2CC7H7O2)(dppm)2]PF6-hmxbato Induces ROS-Mediated Apoptosis in Lung Tumor Cells Producing Selective Cytotoxicity

Scientists analyzed the anticancer potential of hmxbato against lung tumor cells, as well as the partial death mechanisms involved.
[Scientific Reports]
Costa, M. S., Gonçalves, Y. G., Borges, B. C., Silva, M. J. B., Amstalden, M. K., Costa, T. R., Antunes, L. M. G., Rodrigues, R. S., Rodrigues, V. de M., de Faria Franca, E., Zoia, M. A. P., de Araújo, T. G., Goulart, L. R., Von Poelhsitz, G., & Yoneyama, K. A. G. (2020). Ruthenium (II) complex cis -[Ru II (ŋ 2 -O 2 CC 7 H 7 O 2 )(dppm) 2 ]PF 6 -hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity. Scientific Reports, 10(1), 15410. https://doi.org/10.1038/s41598-020-72420-w Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share