Scientists revealed an important role for EGFR–AKT–FOXO1–KLF6–E-cadherin axis in mutant p53-induced cell migration and tumor metastasis.
[Cell Death & Disease]
Researchers showed that miR-135a was aberrantly downregulated in non-small cell lung cancer (NSCLC) cells in comparison with normal bronchial epithelial cells, and the expression of miR-135a inhibited proliferation, invasion and metastasis of NSCLC cells in vitro.
Scientists demonstrated whether LINC00324 participates in non-small cell lung cancer pathogenesis through other molecular mechanism.
[Molecular and Cellular Biochemistry]
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Zhang, M., Lin, B., Liu, Y., Huang, T., Chen, M., Lian, D., Deng, S., & Zhuang, C. (2020). LINC00324 affects non-small cell lung cancer cell proliferation and invasion through regulation of the miR-139-5p/IGF1R axis. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03819-2 Cite
Two cisplatin-resistant non-small cell lung cancer cell lines were established by gradually increasing concentrations of cisplatin in the media. The resulting cell lines possessed high resistance to cisplatin and strong proliferation, migration, and colony formation abilities compared to the parental cells.
[Acta Biochimica Et Biophysica Sinica]
The authors review the molecular biology characteristics of small cell lung cancer (SCLC) and discuss the opportunities and obstacles of the current therapy for SCLC patients.
[Journal of Drug Targeting]
Pulmonary toxicity from taxanes presents as an ILD‐type reaction characterized by increasing dyspnoea, dry cough, fever and bilateral pulmonary interstitial infiltrates.
Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
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Gu, C., Zhang, Q., Ni, D., Xiao, Q.-F., Cao, L.-F., Fei, C.-Y., Ying, Y., Li, N., & Tao, F. (2020). Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. COPD: Journal of Chronic Obstructive Pulmonary Disease, 0(0), 1–8. https://doi.org/10.1080/15412555.2020.1797657 Cite
Scientists explored the cellular heterogeneity of the human airway epithelium in 10 healthy living volunteers by single-cell RNA profiling. 77,969 cells were collected at 35 distinct locations, from the nose to the 12th division of the airway tree.
[American Journal of Respiratory and Critical Care Medicine]
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Deprez, M., Zaragosi, L.-E., Truchi, M., Becavin, C., Ruiz García, S., Arguel, M.-J., Plaisant, M., Magnone, V., Lebrigand, K., Abelanet, S., Brau, F., Paquet, A., Pe’er, D., Marquette, C.-H., Leroy, S., & Barbry, P. (2020). A Single-cell Atlas of the Human Healthy Airways. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201911-2199OC Cite
Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers.
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Roh, J., Lee, J., Sung, Y.-H., Oh, J., Hyeon, D. Y., Kim, Y., Lee, S., Devkota, S., Kim, H. J., Park, B., Nam, T., Song, Y., Kim, Y., Hwang, D., & Lee, H.-W. (2020). Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer. Oncogene, 1–12. https://doi.org/10.1038/s41388-020-01399-5 Cite
Scientists explored the expressions of cell phenotype markers and differentiation regulators in isolated type II alveolar epithelial stem cells (AEC II) to analyze the correlation between GSK‐3β/TGF‐β1/β‐catenin signaling pathway, lin28/let‐7 balance, and AEC II phenotypes at different injury phases following irradiation.
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Zhang, T., Zhou, J., Yue, H., Du, C., Xiao, Z., Zhao, W., Li, N., Wang, X., Liu, X., Li, Y., Geng, X., Zhang, Y., Li, L., & Tian, J. (n.d.). Glycogen synthase kinase-3β promotes radiation-induced lung fibrosis by regulating β-catenin/lin28 signaling network to determine type II alveolar stem cell transdifferentiation state. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202001518 Cite
Continue reading “Glycogen Synthase Kinase‐3β Promotes Radiation‐Induced Lung Fibrosis by Regulating β‐Catenin/lin28 Signaling Network to Determine Type II Alveolar Stem Cell Transdifferentiation State”
The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
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Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]