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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
KEAP1 and STK11/LKB1 Alterations Enhance Vulnerability to ATR Inhibition in KRAS Mutant Non-Small Cell Lung Cancer
[Cancer Cell] Investigators demonstrated that KEAP1-NRF2 pathway drives a compensatory modulation of ATM- and Rad3-Related (ATR)-CHK1 signaling, enhancing vulnerability to ATR inhibitors, particularly in the setting of increased replication stress associated with LKB1 loss.
Asiaticoside Mitigates Chronic Obstructive Pulmonary Disease by Modulating TRIM27 Stability and Activating PGC-1α/Nrf2 Signaling
[Applied Biochemistry and Biotechnology] The pharmacological influences of asiaticoside in COPD were probed. COPD mice were exposed to cigarette smoke, and BEAS-2B cells were treated with cigarette smoke extract for in vitro studies.
Upstream Bio Announces First Patient Dosed in Phase II Clinical Trial of Verekitug in Chronic Obstructive Pulmonary Disease (COPD)
Upstream Bio, Inc. announced that the first patient has been dosed in the company’s Phase II clinical trial evaluating verekitug in patients with COPD,...
Nanodrug Modulates Premetastatic Niche and Suppresses Metastatic Lung Adenocarcinoma Via Programmed Cell Death Ligand 1 Blockade and STING Pathway Activation
[ACS Nano] Scientists developed a premetastatic niche-targeted nanodrug by coating programmed cell death protein 1 (PD-1)-high expressed T cell membranes on the surface of STING activator 2′3′-cGAMP-loaded PLGA@MnO2 nanoparticles (PSMP) for suppressing metastatic LUAD.
Hippo Pathway Controls Biopterin Metabolism to Shield Adjacent Cells from Ferroptosis in Lung Cancer
[EMBO Reports] Analysis of human lung adenocarcinoma and murine models revealed that cancer cells display heterogeneous YAP/TAZ activation levels within tumors. Murine lung cancer cells with high YAP/TAZ activity grow rapidly but are sensitive to ferroptosis, a cell death induced by lipid peroxidation.
Proteome Changes Associated With Effect of High Dose Single-Fractionation Radiation on Lung Adenocarcinoma Cell Lines
[Scientific Reports] Researchers investigated high-dose radiation-induced proteomic changes in the lung adenocarcinoma cell line HCC-44, grown adherently, and in the cell line A549, grown as adherent cells or spheroids.
Efficacy Analysis of Endostar Combined With Chemoradiotherapy and Immune Checkpoint Inhibitors in Locally Advanced Non-Small Cell Lung Cancer
[Discover Oncology] Investigators evaluated the efficacy and adverse reactions of recombinant human endostatin combined with chemoradiotherapy and immune drugs in patients with locally advanced non-small cell lung cancer who could not undergo surgery.
Recent Advances and Challenges of Cellular Immunotherapies in Lung Cancer Treatment
[Experimental Hematology & Oncology] The authors highlight recent advances and challenges in the use of cellular immunotherapies for the treatment of lung cancer, which might stimulate new ideas for the further development of cellular immunotherapies.
Exploring the Potential of PLGA Nanoparticles for Enhancing Pulmonary Drug Delivery
[Molecular Pharmaceutics] Scientists evaluate the advantages of poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles for pulmonary drug delivery, with a focus on their potential to enhance inhalation therapy formulations.
Association of Electronic Cigarette Use and Risk of COPD: A Systematic Review and Meta-Analysis
[NPJ Primary Care Respiratory Medicine] This systematic review and meta-analysis assess the relationship between e-cigarette use and odds of having COPD.
Hippo Pathway Controls Biopterin Metabolism to Shield Adjacent Cells from Ferroptosis in Lung Cancer
[EMBO Reports] Analysis of human lung adenocarcinoma and murine models revealed that cancer cells display heterogeneous YAP/TAZ activation levels within tumors. Murine lung cancer cells with high YAP/TAZ activity grow rapidly but are sensitive to ferroptosis, a cell death induced by lipid peroxidation.
TFIIB-Related Factor 2 Inhibits Lung Squamous Carcinoma Cell Apoptosis through SLC8A3-Mediated Mitochondrial Homeostasis
[Cell Death & Disease] Flow cytometry, protein blotting, and in vivo experiments were performed to assess the function of TFIIB-related factor 2 in lung squamous carcinoma.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
