Scientists investigated the effects of in vivo PTC596 treatment, which affects BMI-1 activity, in murine model.
[Communications Biology]
0
Category Archives: Pulmonary Cell
Pulmonary Cell NewsPulmonary Cell News is an online publication and email newsletter dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
Identification of a Targetable KRAS-Mutant Epithelial Population in Non-small Cell Lung Cancer
PD-L1 lncRNA Splice Isoform Promotes Lung Adenocarcinoma Progression via Enhancing C-Myc Activity
Employing qRT-PCR, Sanger sequencing, and RNA BaseScope analysis, scientists showed that human lung adenocarcinoma (LUAD) all produce a long non-coding RNA isoform of programmed death-ligand 1 (PD-L1) (PD-L1-lnc) by alternative splicing, regardless if the tumor is positive or negative for the protein PD-L1.
[Genome Biology]
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Repression of the AURKA-CXCL5 Axis Induces Autophagic Cell Death and Promotes Radiosensitivity in Non-Small-Cell Lung Cancer
Researchers showed that Aurora inase A (AURKA) was upregulated in non-small-cell lung cancer (NSCLC) cell lines and tissues and that AURKA overexpression was significantly related to a poor prognosis, tumor stage and lymph node metastasis in NSCLC.
[Cancer Letters]
0
SOD1 Regulates Ribosome Biogenesis in KRAS Mutant Non-small Cell Lung Cancer
Researchers describeed the generation of an inducible Sod1 knockout in KRAS-driven NSCLC mouse model.
[Nature Communications]
0
Physiological and Inflammatory Consequences of High and Low Respiratory Rate in Acute Respiratory Distress Syndrome
In this narrative review, the authors present their point of view over the main experimental and clinical evidence available regarding the effect of respiratory rate on ventilator‐induced lung injury development.
[Acta Anaesthesiologica Scandinavica]
0
Cyclica Teams Up with Top-Tier Academic Institutions to Identify a Repurposed Drug for COVID
Cyclica, in connection with leading Canadian research institutions, had predicted a drug, capmatinib, can be repurposed to attenuate the impact of coronavirus.
[Cyclica]
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Cardialen Announces Positive Results from Low-Voltage MultiPulse Therapy to Terminate Atrial Fibrillation
Cardialen, Inc., has published a first-in-human study in the Journal of the American College of Cardiology: Clinical Electrophysiology titled Novel Low-Voltage MultiPulse Therapy to Terminate Atrial Fibrillation.
[Cardialen (businesswire)]
0
SCAMP3 Is a Mutant EGFR Phosphorylation Target and a Tumor Suppressor in Lung Adenocarcinoma
Scientist used quantitative mass-spectrometry-based phosphoproteomics to identify secretory carrier membrane proteins (SCAMP3) as a target of mutant epidermal growth factor receptor in lung adenocarcinoma and further investigated the role of SCAMP3 in the regulation of lung tumorigenesis.
[Oncogene]
0
HIF-1α Promoted Vasculogenic Mimicry Formation in Lung Adenocarcinoma through NRP1 Upregulation in the Hypoxic Tumor Microenvironment
Researchers explored the role of the HIF-1α/NRP1 axis in mediating lung adenocarcinoma metastasis and vasculogenic mimicry (VM) formation.
[Cell Death & Disease]
0
Distinct Uptake, Amplification, and Release of SARS-CoV-2 by M1 and M2 Alveolar Macrophages
Investigators showed that classically activated M1 alveolar macrophages (AMs) facilitated viral spread; however, alternatively activated M2 AMs limited the spread.
[Cell Discovery]
0
Therapeutic Targeting of ATR Yields Durable Regressions in Small Cell Lung Cancers with High Replication Stress
Using chemical genetic screens, scientists identified inhibition of ataxia telangiectasia and rad3 related (ATR), the primary activator of the replication stress response, and topoisomerase I (TOP1), nuclear enzyme that suppressed genomic instability, as synergistically cytotoxic in small cell lung cancer (SCLC).
[Cancer Cell]
0
