Category Archives: Pulmonary Cell

Pulmonary Cell News is an online publication and email newsletter dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

Novel lncRNA UPLA1 Mediates Tumorigenesis and Prognosis in Lung Adenocarcinoma

Scientists showed that upregulation promoting LUAD-associated transcript-1 (UPLA1) was highly expressed and regulated important biological functions in lung adenocarcinoma. In vitro experiments revealed that UPLA1 promoted the migration, invasion, and proliferation abilities, and was related to cell cycle arrest, in lung adenocarcinoma cells.
[Cell Death & Disease]
Han, X., Jiang, H., Qi, J., Li, J., Yang, J., Tian, Y., Li, W., Jing, Q., & Wang, C. (2020). Novel lncRNA UPLA1 mediates tumorigenesis and prognosis in lung adenocarcinoma. Cell Death & Disease, 11(11), 1–12. https://doi.org/10.1038/s41419-020-03198-y Cite
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Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

The authors performed a quantitative phosphoproteomic survey of induced pluripotent stem cell-derived alveolar epithelial type 2 cells infected with SARS-CoV-2 at air-liquid interface.
[Molecular Cell]
Hekman, R. M., Hume, A. J., Goel, R. K., Abo, K. M., Huang, J., Blum, B. C., Werder, R. B., Suder, E. L., Paul, I., Phanse, S., Youssef, A., Alysandratos, K. D., Padhorny, D., Ojha, S., Mora-Martin, A., Kretov, D., Ash, P., Verma, M., Zhao, J., … Emili, A. (2020). Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2020.11.028 Cite
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AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small Cell Lung Cancer

AMG 757 efficacy was evaluated in small cell lung cancer (SCLC) cell lines and in orthotopic and patient-derived xenograft mouse SCLC models. Following AMG 757 administration, changes in tumor volume, pharmacodynamic changes in tumor-infiltrating T cells (TILs), and the spatial relationship between the appearance of TILs and tumor histology were examined. Tolerability was assessed in nonhuman primates.
[Clinical Cancer Research]
Giffin, M. J., Cooke, K., Lobenhofer, E. K., Estrada, J. C., Zhan, J., Deegen, P., Thomas, M., Murawsky, C. M., Werner, J., Liu, S., Lee, F., Homann, O., Friedrich, M., Pearson, J. T., Raum, T., Yang, Y., Caenepeel, S., Stevens, J., Beltran, P. J., … Hughes, P. E. (2020). AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small Cell Lung Cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-2845 Cite
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A Fusion of CD63–BCAR4 Identified in Lung Adenocarcinoma Promotes Tumorigenicity and Metastasis

Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]
Bae, K., Kim, J. H., Jung, H., Kong, S.-Y., Kim, Y.-H., Kim, S., Lee, G. K., Lee, J. S., Lee, J. J.-K., Ju, Y. S., Choi, Y.-K., & Yoon, K.-A. (2020). A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-01146-3 Cite
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TGFβ Promotes YAP‐Dependent AXL Induction in Mesenchymal‐Type Lung Cancer Cells

Researchers revealed that the YAP signature, which was highly enriched in mesenchymal‐type lung cancer, was closely correlated to AXL expression in 181 lung cancer cell lines. Moreover, using isogenic lung cancer cell pairs, they also found that doxorubicin treatment induced YAP nuclear translocation in mesenchymal‐type lung cancer cells to induce AXL expression.
[Molecular Oncology]
Choi, J.-Y., Lee, H., Kwon, E.-J., Kong, H.-J., Kwon, O.-S., & Cha, H.-J. (n.d.). TGFβ promotes YAP-dependent AXL induction in mesenchymal-type lung cancer cells. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12857 Cite
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Engineered Mutant α-ENaC Subunit mRNA Delivered by Lipid Nanoparticles Reduces Amiloride Currents in Cystic Fibrosis–Based Cell and Mice Models

Airway dehydration and impaired mucociliary clearance in cystic fibrosis is proposed to result in tonic epithelial sodium channel (ENaC) activity, which drives amiloride-sensitive electrogenic sodium absorption. Decreasing sodium absorption by inhibiting ENaC can reverse airway surface liquid dehydration. Researchers inhibited endogenous heterotrimeric ENaC channels by introducing inactivating mutant ENaC α mRNA.
[Science Advances]
Mukherjee, A., MacDonald, K. D., Kim, J., Henderson, M. I., Eygeris, Y., & Sahay, G. (2020). Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis–based cell and mice models. Science Advances, 6(47), eabc5911. https://doi.org/10.1126/sciadv.abc5911 Cite
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Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

The authors established a screening strategy to identify drugs that reduce angiotensin converting enzyme 2 levels in human ESC-derived cardiac cells and lung organoids.
[Cell Stem Cell]
Samuel, R. M., Majd, H., Richter, M. N., Ghazizadeh, Z., Zekavat, S. M., Navickas, A., Ramirez, J. T., Asgharian, H., Simoneau, C. R., Bonser, L. R., Koh, K. D., Garcia-Knight, M., Tassetto, M., Sunshine, S., Farahvashi, S., Kalantari, A., Liu, W., Andino, R., Zhao, H., … Fattahi, F. (2020). Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.11.009 Cite
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Medicinal Potential of Mycelium and Fruiting Bodies of an Arboreal Mushroom Fomitopsis officinalis in Therapy of Lifestyle Diseases

Researchers aimed to investigate the antiproliferative activity of mycelium extracts and F. officinalis sporocarps against the the DU145 prostate cancer cell line, a melanoma cell line and a lung cancer cell line.
[Scientific Reports]
Fijałkowska, A., Muszyńska, B., Sułkowska-Ziaja, K., Kała, K., Pawlik, A., Stefaniuk, D., Matuszewska, A., Piska, K., Pękala, E., Kaczmarczyk, P., Piętka, J., & Jaszek, M. (2020). Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases. Scientific Reports, 10(1), 20081. https://doi.org/10.1038/s41598-020-76899-1 Cite
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Scutellarin Ameliorates Pulmonary Fibrosis through Inhibiting NF-κB/NLRP3-Mediated Epithelial–Mesenchymal Transition and Inflammation

Investigators discovered that scutellarin suppressed inflammation and epithelial–mesenchymal transition in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling.
[Cell Death & Disease]
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation | Cell Death & Disease. (n.d.). Retrieved November 19, 2020, from https://www.nature.com/articles/s41419-020-03178-2 Cite
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ADAM17 Deficiency Protects Against Pulmonary Emphysema

Histological, immunohistochemical, immunofluorescence and molecular analyses, as well as lung function tests, were performed to assess pulmonary emphysema, inflammation and alveolar cell apoptosis.
[American Journal of Respiratory Cell and Molecular Biology]
ADAM17 Deficiency Protects Against Pulmonary Emphysema | American Journal of Respiratory Cell and Molecular Biology | Articles in Press. (n.d.). Retrieved November 19, 2020, from https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2020-0214OC Cite
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OTUD7B Suppresses Smac Mimetic-Induced Lung Cancer Cell Invasion and Migration via Deubiquitinating TRAF3

Scientists assessed lung cancer cell elongation, invasion and migration under treatment with the Smac mimetic LCL161. Functional analyses (in vitro and in vivo) were performed to detect the contribution of NIK and OTUD7B to LCL161-induced cell invasion and migration. The role of OTUD7B in regulation of the TRAF3/NIK/NF-κB pathway under LCL161 treatment was analysed by immunoblotting, immunoprecipitation, luciferase and ubiquitin assays, shRNA silencing and plasmid overexpression. Expression levels of OTUD7B, NIK and TRAF3 in tissue samples from lung cancer patients were examined by immunohistochemistry.
[Journal of Experimental & Clinical Cancer Research]
Zhang, B., Yang, C., Wang, R., Wu, J., Zhang, Y., Liu, D., Sun, X., Li, X., Ren, H., & Qin, S. (2020). OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3. Journal of Experimental & Clinical Cancer Research, 39(1), 244. https://doi.org/10.1186/s13046-020-01751-3 Cite
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