Scientists showed that upregulation promoting LUAD-associated transcript-1 (UPLA1) was highly expressed and regulated important biological functions in lung adenocarcinoma. In vitro experiments revealed that UPLA1 promoted the migration, invasion, and proliferation abilities, and was related to cell cycle arrest, in lung adenocarcinoma cells.
[Cell Death & Disease]
The authors performed a quantitative phosphoproteomic survey of induced pluripotent stem cell-derived alveolar epithelial type 2 cells infected with SARS-CoV-2 at air-liquid interface.
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Hekman, R. M., Hume, A. J., Goel, R. K., Abo, K. M., Huang, J., Blum, B. C., Werder, R. B., Suder, E. L., Paul, I., Phanse, S., Youssef, A., Alysandratos, K. D., Padhorny, D., Ojha, S., Mora-Martin, A., Kretov, D., Ash, P., Verma, M., Zhao, J., … Emili, A. (2020). Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2020.11.028 Cite
AMG 757 efficacy was evaluated in small cell lung cancer (SCLC) cell lines and in orthotopic and patient-derived xenograft mouse SCLC models. Following AMG 757 administration, changes in tumor volume, pharmacodynamic changes in tumor-infiltrating T cells (TILs), and the spatial relationship between the appearance of TILs and tumor histology were examined. Tolerability was assessed in nonhuman primates.
[Clinical Cancer Research]
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Giffin, M. J., Cooke, K., Lobenhofer, E. K., Estrada, J. C., Zhan, J., Deegen, P., Thomas, M., Murawsky, C. M., Werner, J., Liu, S., Lee, F., Homann, O., Friedrich, M., Pearson, J. T., Raum, T., Yang, Y., Caenepeel, S., Stevens, J., Beltran, P. J., … Hughes, P. E. (2020). AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small Cell Lung Cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-2845 Cite
Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]
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Bae, K., Kim, J. H., Jung, H., Kong, S.-Y., Kim, Y.-H., Kim, S., Lee, G. K., Lee, J. S., Lee, J. J.-K., Ju, Y. S., Choi, Y.-K., & Yoon, K.-A. (2020). A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-01146-3 Cite
Researchers revealed that the YAP signature, which was highly enriched in mesenchymal‐type lung cancer, was closely correlated to AXL expression in 181 lung cancer cell lines. Moreover, using isogenic lung cancer cell pairs, they also found that doxorubicin treatment induced YAP nuclear translocation in mesenchymal‐type lung cancer cells to induce AXL expression.
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Choi, J.-Y., Lee, H., Kwon, E.-J., Kong, H.-J., Kwon, O.-S., & Cha, H.-J. (n.d.). TGFβ promotes YAP-dependent AXL induction in mesenchymal-type lung cancer cells. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12857 Cite
Airway dehydration and impaired mucociliary clearance in cystic fibrosis is proposed to result in tonic epithelial sodium channel (ENaC) activity, which drives amiloride-sensitive electrogenic sodium absorption. Decreasing sodium absorption by inhibiting ENaC can reverse airway surface liquid dehydration. Researchers inhibited endogenous heterotrimeric ENaC channels by introducing inactivating mutant ENaC α mRNA.
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Mukherjee, A., MacDonald, K. D., Kim, J., Henderson, M. I., Eygeris, Y., & Sahay, G. (2020). Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis–based cell and mice models. Science Advances, 6(47), eabc5911. https://doi.org/10.1126/sciadv.abc5911 Cite
The authors established a screening strategy to identify drugs that reduce angiotensin converting enzyme 2 levels in human ESC-derived cardiac cells and lung organoids.
[Cell Stem Cell]
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Samuel, R. M., Majd, H., Richter, M. N., Ghazizadeh, Z., Zekavat, S. M., Navickas, A., Ramirez, J. T., Asgharian, H., Simoneau, C. R., Bonser, L. R., Koh, K. D., Garcia-Knight, M., Tassetto, M., Sunshine, S., Farahvashi, S., Kalantari, A., Liu, W., Andino, R., Zhao, H., … Fattahi, F. (2020). Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.11.009 Cite
Researchers aimed to investigate the antiproliferative activity of mycelium extracts and F. officinalis sporocarps against the the DU145 prostate cancer cell line, a melanoma cell line and a lung cancer cell line.
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Fijałkowska, A., Muszyńska, B., Sułkowska-Ziaja, K., Kała, K., Pawlik, A., Stefaniuk, D., Matuszewska, A., Piska, K., Pękala, E., Kaczmarczyk, P., Piętka, J., & Jaszek, M. (2020). Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases. Scientific Reports, 10(1), 20081. https://doi.org/10.1038/s41598-020-76899-1 Cite
Investigators discovered that scutellarin suppressed inflammation and epithelial–mesenchymal transition in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling.
[Cell Death & Disease]
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Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation | Cell Death & Disease. (n.d.). Retrieved November 19, 2020, from https://www.nature.com/articles/s41419-020-03178-2 Cite
Histological, immunohistochemical, immunofluorescence and molecular analyses, as well as lung function tests, were performed to assess pulmonary emphysema, inflammation and alveolar cell apoptosis.
[American Journal of Respiratory Cell and Molecular Biology]
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ADAM17 Deficiency Protects Against Pulmonary Emphysema | American Journal of Respiratory Cell and Molecular Biology | Articles in Press. (n.d.). Retrieved November 19, 2020, from https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2020-0214OC Cite
Scientists assessed lung cancer cell elongation, invasion and migration under treatment with the Smac mimetic LCL161. Functional analyses (in vitro and in vivo) were performed to detect the contribution of NIK and OTUD7B to LCL161-induced cell invasion and migration. The role of OTUD7B in regulation of the TRAF3/NIK/NF-κB pathway under LCL161 treatment was analysed by immunoblotting, immunoprecipitation, luciferase and ubiquitin assays, shRNA silencing and plasmid overexpression. Expression levels of OTUD7B, NIK and TRAF3 in tissue samples from lung cancer patients were examined by immunohistochemistry.
[Journal of Experimental & Clinical Cancer Research]
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Zhang, B., Yang, C., Wang, R., Wu, J., Zhang, Y., Liu, D., Sun, X., Li, X., Ren, H., & Qin, S. (2020). OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3. Journal of Experimental & Clinical Cancer Research, 39(1), 244. https://doi.org/10.1186/s13046-020-01751-3 Cite