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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
A Clinically Effective Model Based on Cell-Free DNA Methylation and Low-Dose CT for Risk Stratification of Pulmonary Nodules
[Cell Reports Medicine] The authors performed genome-wide methylation sequencing on malignant and non-malignant lung tissues and designed a panel of 263 differential DNA methylation regions, which was used for targeted methylation sequencing on blood cell-free DNA in two prospectively collected and retrospectively analyzed multicenter cohorts.
GTSE1-Driven ZEB1 Stabilization Promotes Pulmonary Fibrosis Through the Epithelial-to-Mesenchymal Transition
[Molecular Therapy] Investigators explored the genomic data of patients with idiopathic PF (IPF) and found that GTSE1 expression is elevated in their lung tissues, but rarely expressed in normal lung tissues.
Serum β2-Microglobulin as an Independent Risk Factor for Mortality in Patients with Acute Respiratory Distress Syndrome Caused by Bacterial Infection
[Scientific Reports] Scientists retrospectively enrolled 257 patients with ARDS caused by bacterial infection from January 1, 2015 to February 28, 2021. Patients were followed for up to 28 days and were divided into a survival group and non-survival group according to their clinical outcomes.
Identification of DNA Methylation Markers for Age and Bovine Respiratory Disease in Dairy Cattle: A Pilot Study Based on Reduced Representation Bisulfite Sequencing
[Communications Biology] The authors performed a pilot study to investigate the epigenetic profile of BRD susceptibility in six calves and age-related methylation differences between healthy calves and adult dairy cows using Reduced Representation Bisulfite Sequencing.
The miRNA and PD-1/PD-L1 Signaling Axis: An Arsenal of Immunotherapeutic Targets Against Lung Cancer
[Cell Death Discovery] Investigators explored the role of miRNAs in modulating immunogenic responses against tumors. They discuss various aspects of how manipulating these checkpoints can bias the immune system’s response against lung cancer.
Linkous Advances Lung Cancer Research with Merck Research Laboratories Scientific Engagement and Emerging Discovery Science Program
Amanda Linkous, research associate professor of pharmacology, has been awarded a research grant from the Merck Research Laboratories Scientific Engagement and Emerging Discovery Science...
Il-13 Induces Loss of CFTR in Ionocytes and Reduces Airway Epithelial Fluid Absorption
[Journal of Clinical Investigation] The authors demonstrated that ionocytes can increase liquid absorption through apical CFTR and basolateral barttin/chloride channels, while airway secretory cells mediate liquid secretion through apical CFTR channels and basolateral NKCC1 transporters.
PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function
[Nature Communications] Combination of single-cell RNA-seq, bulk ATAC-seq, and CUT&RUN data demonstrate that PRDM3 and PRDM16 regulate chromatin accessibility at NKX2-1 transcriptional targets critical for perinatal AT2 cell differentiation and surfactant homeostasis.
Analysis and Identification of mRNAsi-Related Expression Signatures via RNA Sequencing in Lung Cancer
[Oncology Letters] Tumor tissue, paracancerous tissue, peripheral blood and lymph node samples were collected from patients with stage I‑III non‑small cell lung cancer and RNA sequencing was performed. The TCGAbiolinks package was used to calculate the mRNAsi for each of these four types of sample.
Durvalumab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer
[New England Journal of Medicine] In a Phase III, double-blind, randomized, placebo-controlled trial, researchers assigned patients to receive durvalumab at a dose of 1500 mg, durvalumab plus tremelimumab at a dose of 75 mg, or placebo every four weeks for up to 24 months.
Nasal Epithelial Gene Expression Identifies Relevant Asthma Endotypes in the ATLANTIS Study
[Thorax] Researchers analyzed nasal epithelial gene expression data from 369 patients with asthma and 58 non-asthmatic controls from the Assessment of Small Airways Involvement in Asthma study. Unsupervised hierarchical clustering was performed on asthma-associated genes.
$15K Award Goes to Researcher for Work Into IPF Disease Risk Factors
[Pulmonary Fibrosis News] A University of Colorado professor has won the 2024 Alton Ochsner Award Relating Smoking and Disease for his work into how genetic and environmental factors, including smoking, contribute to a person’s risk of idiopathic pulmonary fibrosis (IPF)— when the disease is due to unknown causes.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
