Discovery of Gefitinib-1,2, 3-Triazole Derivatives against Lung Cancer via Inducing Apoptosis and Inhibiting the Colony Formation

A series of 20 novel gefitinib derivatives incorporating the 1,2,3-triazole moiety were designed and synthesized. The synthesized compounds were evaluated for their potential anticancer activity against epidermal growth factor receptor wild-type human NSCLC cells and human lung adenocarcinoma cells as NSCLC.