The genetic reintroduction of BLOC1S1 rescued lysosomal tubulation in liver-specific knockout hepatocytes, but not when KIF5B was concurrently depleted.
The authors discovered that targeting EphA2 suppressed both AKT and JAK1/STAT3 signaling, two separate oncogenic pathways in hepatocelllar carcinoma.
6445212 9MKLXEJU items 1 apa default asc 1
Wang, H., Hou, W., Perera, A., Bettler, C., Beach, J. R., Ding, X., Li, J., Denning, M. F., Dhanarajan, A., Cotler, S. J., Joyce, C., Yin, J., Ahmed, F., Roberts, L. R., & Qiu, W. (2021). Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108765 Cite
Investigators report that TPC2 knockout reduced proliferation of cancer cells in vitro, affected their energy metabolism, and successfully abrogated tumor growth in vivo.
[Cell Chemical Biology]
6445212 DI286A4W items 1 apa default asc 1
Müller, M., Gerndt, S., Chao, Y.-K., Zisis, T., Nguyen, O. N. P., Gerwien, A., Urban, N., Müller, C., Gegenfurtner, F. A., Geisslinger, F., Ortler, C., Chen, C.-C., Zahler, S., Biel, M., Schaefer, M., Grimm, C., Bracher, F., Vollmar, A. M., & Bartel, K. (2021). Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2021.01.023 Cite
Scientists revealed that USP39 was highly expressed in human hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis. USP39 depletion inhibited HCC cell proliferation and metastasis by promoting ZEB1 degradation.
[Cell Death & Differentiation]
6445212 CYCYHEYZ items 1 apa default asc 1
Li, X., Yuan, J., Song, C., Lei, Y., Xu, J., Zhang, G., Wang, W., & Song, G. (2021). Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma. Cell Death & Differentiation, 1–18. https://doi.org/10.1038/s41418-021-00754-7 Cite
Researchers found that SIRT2 was significantly downregulated in livers from advanced NAFLD patients and high‐fat diet (HFD)‐induced non-alcoholic liver disease mice. They revealed that SIRT2 was markedly decreased in obese mice and in palmitate‐treated HepG2 cells.
The authors validated the increased m6A modification and elevated YTHDF1 protein level in sublethal‐heat‐treated hepatocellular carcinoma (HCC) cell lines, HCC patient‐derived xenograft mouse model and patients’ HCC tissues.
6445212 WQBJSVCD items 1 apa default asc 1
Su, T., Huang, M., Liao, J., Lin, S., Yu, P., Yang, J., Cai, Y., Zhu, S., Xu, L., Peng, Z., Peng, S., Chen, S., & Kuang, M. (n.d.). Insufficient Radiofrequency Ablation Promotes Hepatocellular Carcinoma Metastasis through m6A mRNA Methylation Dependent Mechanism. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31766 Cite
Cell proliferation tracing revealed that, at the whole hepatocyte–population level, more proliferation was detected in a subset of midzonal hepatocytes during liver homeostasis, with less proliferation in periportal hepatocytes and minimal proliferation in pericentral hepatocytes.
6445212 QF6R3Y6K items 1 apa default asc 1
He, L., Pu, W., Liu, X., Zhang, Z., Han, M., Li, Y., Huang, X., Han, X., Li, Y., Liu, K., Shi, M., Lai, L., Sun, R., Wang, Q.-D., Ji, Y., Tchorz, J. S., & Zhou, B. (2021). Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science, 371(6532). https://doi.org/10.1126/science.abc4346 Cite
Genetic ablation or depletion of PPM1A in cells, organoids, and mice elicited an enhanced Yes-associated protein (YAP)/TAZ cytoplasmic retention and resulted in the diminished cell proliferation, severe gut regeneration defects in colitis, and impeded liver regeneration upon injury.
1254621 S2DGGRSR items 1 apa default asc 1
Zhou, R., Wu, Q., Wang, M., Irani, S., Li, X., Zhang, Q., Meng, F., Liu, S., Zhang, F., Wu, L., Lin, X., Wang, X., Zou, J., Song, H., Qin, J., Liang, T., Feng, X.-H., Zhang, Y. J., & Xu, P. (2021). The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration. PLOS Biology, 19(2), e3001122. https://doi.org/10.1371/journal.pbio.3001122 Cite
The authors reported the novel of tumor cell-expressed Piwi Like RNA-Mediated Gene Silencing 1 (PIWIL1) in mediating the crosstalk of fatty acid metabolism and immune response of human hepatocellular carcinoma.
[Signal Transduction and Targeted Therapy]
6445212 MFZSRH7U items 1 apa default asc 1
Wang, N., Tan, H.-Y., Lu, Y., Chan, Y.-T., Wang, D., Guo, W., Xu, Y., Zhang, C., Chen, F., Tang, G., & Feng, Y. (2021). PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-021-00485-8 Cite
Can-Fite BioPharma Ltd. announced new data from the Phase II advanced liver cancer study including overall survival of nearly 4 years in two patients who are under namodenoson treatment.
[Can-Fite BioPharma Ltd.]
6445212 nan items 1 apa default asc 1
Arch Biopartners, Inc. announced that the Peter Lougheed Center in Calgary, Alberta has joined the Phase II trial of its lead drug LSALT peptide, targeting the prevention of acute lung injury, acute kidney injury, and other complications caused by inflammation in hospitalized patients with moderate to severe cases of COVID-19.
[Arch Biopartners, Inc.]
6445212 nan items 1 apa default asc 1