Category Archives: Hepatic Cell

Hepatic Cell News is an online publication and email newsletter covering the top research on hepatocytes and liver diseases.
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The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. The newsletter covers areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma

Three metastasis-associated circRNAs identified in a previous circRNA-sequencing study were screened and validated in two hepatocellular carcinoma (HCC) cohorts. CircRPN2 was downregulated in highly metastatic HCC cell lines and HCC tissues with metastasis.
[Cancer Research]
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Recapitulating Hepatitis E Virus–Host Interactions and Facilitating Antiviral Drug Discovery in Human Liver–Derived Organoids

Scientists demonstrated that 3D cultured organoids from fetal and adult human liver with cholangiocyte or hepatocyte phenotype supported hepatitis E virus replication.
[Science Advances]
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The Portrait of Liver Cancer Is Shaped by Mitochondrial Genetics

The authors showed that mitochondrial DNA of the normal liver shaped tumor progression, histology, and immune environment prior to the acquisition of oncogenic mutation.
[Cell Reports]
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Ascletis Announces US IND Approval of ASC22 (Envafolimab), a Subcutaneously Administered PD-L1 Antibody for Functional Cure of Chronic Hepatitis B

Ascletis Pharma, Inc. announced the Investigational New Drug (IND) application approval by US FDA and initiation of global development of ASC22, a first-in-class, subcutaneously administered PD-L1 antibody for functional cure of chronic hepatitis B.
[Ascletis Pharma, Inc.]
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TriSalus Life Sciences Announces Collaboration with the University of Colorado Anschutz Medical Campus to Advance Research on Innovative Immuno-Oncology Treatments for Patients with Liver and Pancreatic Tumors

TriSalus Life Sciences® announced a strategic research collaboration with the University of Colorado Anschutz Medical Campus to advance research of immuno-oncology treatments for patients with liver and pancreatic tumors.
[TriSalus Life Sciences®]
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Sox9/CXCL5 Axis Facilitates Tumor Cell Growth and Invasion in Hepatocellular Carcinoma

Investigators observed that the increase of Sox9 significantly promoted hepatocellular carcinoma cell growth and invasion in cell cultures, whereas knockdown of Sox9 showed the opposite effects, suggesting that Sox9 may regulate the proliferation and invasion of hepatoma cells in an autocrine manner.
[FEBS Journal]
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The Mitochondrial β-Oxidation Enzyme HADHA Restrains Hepatic Glucagon Response by Promoting β-Hydroxybutyrate Production

The authors showed that glucagon challenge impaired the expression of HADHA. Liver-specific HADHA overexpression reversed hepatic gluconeogenesis in mice, while HADHA knockdown augmented glucagon response.
[Nature Communications]
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Dexmedetomidine Promotes Apoptosis and Suppresses Proliferation of Hepatocellular Carcinoma Cells via microRNA-130a/EGR1 Axis

Investigators determined whether dexmedetomidine might have directly regulated miR-130a/early growth response 1 (EGR1) axis in hepatocellular carcinoma and explored the related mechanisms.
[Cell Death Discovery]
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Single-Cell Biology Uncovers Apoptotic Cell Death and Its Spatial Organization as a Potential Modifier of Tumor Diversity in Hepatocellular Carcinoma

Researchers investigated whether apoptotic cell death and its spatial architecture was linked to tumor molecular heterogeneity using single-cell in situ hybridization analysis.
[Hepatology]
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Responsiveness of PNPLA3 and Lipid-Related Transcription Factors Is Dependent upon Fatty Acid Profile in Primary Bovine Hepatocytes

The authors determined if patatin-like phospholipase domain-containing protein 3 (PNPLA3), as well as other lipases, transcription factors, or fatty acid (FA)-mediated genes, were regulated by FA mimicking liver lipid accumulation and liver lipid clearing (RECOV) or singular FA physiologically found in dairy cows at 0.5 mM of circulating RECOV.
[Scientific Reports]
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RNF43/ZNRF3 Loss Predisposes to Hepatocellular-Carcinoma by Impairing Liver Regeneration and Altering the Liver Lipid Metabolic Ground-State

Using hepatocyte-, hepatoblast- and ductal cell-derived organoids, investigators demonstrated that the differentiation defects and lipid alterations were, in part, cell-autonomous.
[Nature Communications]
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