Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Ezra Receives 510(k) FDA Clearance For AI That Enhances MRI, Enabling Fast, Low-Cost Scans

[Hepion Pharmaceuticals, Inc.] Hepion Pharmaceuticals, Inc. announced positive topline results from its recently completed Phase II ALTITUDE-NASH clinical trial. ALTITUDE-NASH demonstrated improved physiologic liver function and was well tolerated after four months of treatment in subjects with stage 3 or greater fibrosis based on the AGILE 3+ criteria.

Lysyl Oxidase-Like 3 Restrains Mitochondrial Ferroptosis To Promote Liver Cancer Chemoresistance by Stabilizing Dihydroorotate Dehydrogenase

[Nature Communications] Researchers screened the lysyl-oxidase family to clarify its contribution to chemotherapy resistance in liver cancer.

Hepatic Stellate Cells Maintain Liver Homeostasis Through Paracrine Neurotrophin-3 Signaling That Induces Hepatocyte Proliferation

[Science Signaling] Hepatic stellate cells were a source of neurotrophin-3, which drove hepatocyte proliferation in vitro and in hepatic stellate cell–depleted mice by stimulating the receptor tropomyosin receptor kinase B.

TRIM21 Ameliorates Hepatic Glucose and Lipid Metabolic Disorders in Type 2 Diabetes Mellitus by Ubiquitination of PEPCK1 and FASN

[Cellular And Molecular Life Sciences] Scientists identified tripartite motif-containing protein 21 (TRIM21), a class IV TRIM family member, as a pivotal regulator of hepatic metabolism in type 2 diabetes mellitus.

Double-Negative T Cells Regulate the Progression of Liver Fibrosis Through Th9 Cells Differentiation

[Liver International] Researchers investigated the role and mechanism of double negative T cells in regulating the Th9 cells differentiation in liver fibrosis

Boosting Intracellular Sodium Selectively Kills Hepatocarcinoma Cells and Induces Hepatocellular Carcinoma Tumor Shrinkage in Mice

[Communications Biology] Scientists evaluated Na+ level in hepatocarcinoma cells and HCC allografts and investigated their sensitivity to a forced Na+ influx induced by the Na+ ionophore in comparison to healthy primary hepatocytes and normal tissues.

Single-Cell RNA Sequencing Reveals the Mediatory Role of Cancer-Associated Fibroblast PTN in Hepatitis B Virus Cirrhosis-HCC Progression

[Gut Pathogens] Researchers revealed cancer-associated fibroblasts (CAF) were associated with hepatocarcinogenesis and the functional importance of B cells and CD8 + T cells in modulating CAF in HCC.

BAIAP2L2 Is a Novel Prognostic Biomarker Related to Migration and Invasion of HCC and Associated With Cuprotosis

[Scientific Reports] The expression of BAIAP2L2 in HCC was analyzed using The Cancer Genome Atlas, Gene Expression Omnibus, International Cancer Genome Consortium, and Human Protein Atlas databases and in vitro experiments.

Non-Target GC–MS Analyses of Fecal VOCs in NASH-Hepatocellular Carcinoma Model STAM Mice

[Scientific Reports] Investigators observed that diacetyl induced α-smooth muscle actin, one of the hallmarks of fibrosis, in an ex vivo cultured hepatic section, but not in in vitro hepatic stellate TWNT-1 cells.

Liver Fibrosis-Derived Exosomal miR-106a-5p Facilitates the Malignancy by Targeting SAMD12 and CADM2 in Hepatocellular Carcinoma

[PLOS One] The authors established miRNAs from exosomes associated with liver fibrosis, and to identify potential biomarkers for the prediction of personalized clinical management effectiveness in HCC.

Recent Understandings About Hypertension Management in Type 2 Diabetes: What Are the Roles of SGLT2 Inhibitor, GLP-1 Receptor Agonist, and Finerenone?

[Hypertension Research] The risk of cardiovascular disease increases by three to six-fold with the coexistence of diabetes and hypertension; therefore, the management of blood pressure to prevent cardiovascular disease is a particularly important issue in patients with diabetes.

β-arrestin2 Deficiency Ameliorates S-100-Induced Autoimmune Hepatitis in Mice by Inhibiting Infiltration of Monocyte-Derived Macrophage and Attenuating Hepatocyte Apoptosis

[Acta Pharmacologica Sinica] Experiments showed that β-arrestin2 deficiency attenuated TNF-α-induced primary hepatocyte apoptosis by activating the Akt/GSK-3β pathway.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!