Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Changes of Circulating Tumor Cells Expressing CD90 and EpCAM in Early-Phase of Atezolizumab and Bevacizumab for Hepatocellular Carcinoma

[Heliyon] Researchers investigated the cellular characteristics of circulating tumor cells focusing on monitoring during atezolizumab and bevacizumab therapy in patients with HCC. Peripheral blood samples were collected from 10 healthy controls and 40 patients with HCC.

Single-Cell Analysis Revealed That MTIF2 Could Promote Hepatocellular Carcinoma Progression Through Modulating the ROS Pathway

[Heliyon] Gene expression analysis on TIMER 2.0, UALCAN, and GEPIA databases was performed to measure the expression of MTIF2 in HCC tissues. Cell clustering subgroups and annotation were conducted based on the single-cell sequencing data of HCC and paracancerous tissues in the Gene Expression Omnibus database.

Metabolic Phenotyping of Patients with Advanced Chronic Liver Disease for Better Characterization of Cirrhosis Regression

[Journal of Hepatology] Investigators assessed clinical factors, perform genotyping of known variants, and comprehensive metabolic phenotyping to characterize the regression of fibrosis in patients with compensated advanced chronic liver disease.

Biological Impact and Therapeutic Implication of Tumor-Associated Macrophages in Hepatocellular Carcinoma

[Cell Death & Disease] Macrophages can provide cell–cell communication in HCC by secreting exosomes having various types of biomolecules that transfer among cells and change their activity.

FXR Activation Remodels Hepatic and Intestinal Transcriptional Landscapes in Metabolic Dysfunction-Associated Steatohepatitis

[Acta Pharmacologica Sinica] By employing integrated transcriptome profiling of diverse FXR agonists-treated mice, FXR liver-specific knockout mice, and open-source human datasets, scientists determined that hepatic FXR activation effectively ameliorated MASH by reversing the dysregulated metabolic and inflammatory networks implicated in MASH pathogenesis.

Protective Function of Sclerosing Cholangitis on IBD

[Gut] Colitis severity was analyzed in experimental mouse models of colitis and sclerosing cholangitis, and people with IBD and PSC-IBD. Foxp3+ Treg-cell infiltration was assessed by qPCR and flow cytometry.

Function of Mast Cell and Bile-Cholangiocarcinoma Interplay in Cholangiocarcinoma Microenvironment

[Gut] Differential metabolites in the bile from CCA and benign biliary stenosis were identified by metabonomics. Biliary molecules able to induce mast cell degranulation were revealed by in vitro and in vivo experiments, including liquid chromatography-mass spectrometry (MS)/MS and bioluminescence resonance energy transfer assays.

Hepatic IL22RA1 Deficiency Promotes Hepatic Steatosis by Modulating Oxysterol in the Liver

Researchers showed hepatic IL22RA1 is vital in hepatic lipid regulation. IL22RA1 was downregulated in palmitic acid-treated mouse primary hepatocytes, as well as in the...

Alcohol Is Driving a Half-Dozen Types of Cancer in the US, Study Finds

[STAT News] Alcohol has long been classified as a cancer-causing substance, but a recent study gave a clearer sense of just how many cancer cases and deaths may be driven by drinking.

13% of Patients with Dementia May Instead Have Cognitive Decline from Cirrhosis

[VCU Health] About 13% of individuals diagnosed with dementia may suffer instead from reversible cognitive decline caused by advanced liver disease, according to researchers from the Virginia Commonwealth University’s School of Medicine and the Richmond VA Medical Center.

Function of Mast Cell and Bile-Cholangiocarcinoma Interplay in Cholangiocarcinoma Microenvironment

Differential metabolites in the bile from CCA and benign biliary stenosis were identified by metabonomics. Biliary molecules able to induce mast cell degranulation were...

BNIP3-Mediated Mitophagy Boosts the Competitive Growth of Lenvatinib-Resistant Cells via Energy Metabolism Reprogramming in HCC

[Heliyon] Scientists based on a contructed lenvitinib-resistant HCC cells displayed obvious competitive growth dominance over sensitive cells through reprogramming energy metabolism.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

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