Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

PLGA-Nano-Encapsulated Disulfiram Inhibits Hypoxia-Induced NFκB, Cancer Stem Cells and Targets Glioblastoma in Vitro and in Vivo

[Molecular Cancer Therapeutics] The in vitro anti-glioblastoma (GBM) stem cell activity of disulfiram (DS) and in vivo anti-GBM efficacy of poly lactic-co-glycolic acid nanoparticle-encapsulated DS were examined.

Optimization of Production and Characterization of a Recombinant Soluble Human Cripto-1 Protein Inhibiting Self-Renewal of Cancer Stem Cells

[Journal of Cellular Biochemistry] A functional form of soluble Cripto-1 was found to be difficult to obtain because of the 12 cysteine residues in the protein which impaired the folding process.

The Role of Cancer Stem Cell-Derived Exosomes in Cancer Progression

[Stem Cell International] Scientists review how CSC-exosomes exert the above effects based on the above two aspects and explore their mechanism of action.

ARL2 Is Required for Homologous Recombination Repair and Colon Cancer Stem Cell Survival

[Febs Open Bio] ARL2 expression was positively associated with the expression of all 6 RAD51 family genes, which are essential for homologous recombination repair.

LGR4 Cooperates with PrPc to Endow the Stemness of Colorectal Cancer Stem Cells Contributing to Tumorigenesis and Liver Metastasis

[Cancer Letters] Researchers reported that a leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) cooperated with CD44 and PrPc; the latter contributes significantly to metastatic capacity and defines the stemness characteristics of colorectal CSCs.

TFEB and TFE3 Depletion Increases Cancer Stem Cell Characteristics and EMT in Triple-Negative Breast Cancer

[FASEB Journal] Scientists showed that knockout of TFEB and combined knockout of TFEB and TFE3 resulted in an increase in stem cell character and epithelial-mesenchymal transition, which could correlate to increased tumor metastasis and poorer prognosis.

FDA Limits Use of J&J Vaccine, Citing Safety Concerns

[The Scientist] The US FDA has limited the use of Johnson & Johnson’s single-shot coronavirus vaccine due to the small risk of developing a rare and potentially life-threatening blood clotting disorder.

Autophagy in PDGFRα+ Mesenchymal Cells Is Essential for Intestinal Stem Cell Survival

[Proceedings of the National Academy of Sciences of the United States of America] Autophagy was required for PDGFRα+ mesenchymal cells (PMC) metabolism and ileum stem cell and mammalian survival. Failure to maintain PMCs through autophagy may therefore contribute to inflammatory bowel diseases.

Revealing the Mechanisms of Weishi Huogu I Capsules Used for Treating Osteonecrosis of the Femoral Head Based on Systems Pharmacology with One Mechanism Validated...

[Journal of Ethnopharmacology] The effects of Weishi Huogu I capsule compounds identified through the systematic pharmacology analysis of the osteogenic transformation of human umbilical MSCs were validated in vitro.

Fast-Curing Injectable Microporous Hydrogel for In Situ Cell Encapsulation

[ACS Applied Bio Materials] When applied for in situ cell encapsulation, encapsulated human dermal fibroblasts and human MSCs were able to rapidly spread and proliferate in the pore space of the hydrogel.

Drug Repositioning of Polaprezinc for Bone Fracture Healing

[Communications Biology] Polaprezinc induced upregulation of osteogenesis-related genes and enhanced the osteogenic potential of human bone marrow-derived MSCs and osteoclast differentiation potential of mouse bone marrow-derived monocytes.

Oxidized High Mobility Group B-1 Enhances Metastability of Colorectal Cancer via Modification of Mesenchymal Stem/Stromal Cells

[Cancer Science] When bone marrow-MSCs pretreated with oxidized high mobility group box-1 were co-cultured with syngeneic cancer cells, cell proliferation and stemness of cancer cells were increased, and tumorigenesis and drug resistance were promoted.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

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