Indole Hydrazide Compound ZJQ-24 Inhibits Angiogenesis and Induces Apoptosis Cell Death through Abrogation of AKT/mTOR Pathway in Hepatocellular Carcinoma

MTT assays, flow cytometric analysis, Western blotting and immunohistochemistry identified that ZJQ-24 effectively suppressed hepatocellular carcinoma cell proliferation via G2/M phase arrest and caspase-dependent apoptosis but had no cytotoxic on normal cells.
[Cell Death & Disease]
Liu, J., Liu, Y., Zhang, J., Liu, D., Bao, Y., Chen, T., Tang, T., Lin, J., Luo, Y., Jin, Y., & Zhang, J. (2020). Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma. Cell Death & Disease, 11(10), 1–13. https://doi.org/10.1038/s41419-020-03108-2 Cite
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Antigen Presentation, Autoantibody Production, and Therapeutic Targets in Autoimmune Liver Disease

Investigators summarize emerging aspects of antigen presentation, autoantibody production, and the application of novel therapeutic approaches in the characterization and treatment of autoimmune liver diseases.
[Cellular & Molecular Immunology]
Horst, A. K., Kumashie, K. G., Neumann, K., Diehl, L., & Tiegs, G. (2020). Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease. Cellular & Molecular Immunology, 1–20. https://doi.org/10.1038/s41423-020-00568-6 Cite
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microRNA-199a-3p Inhibits Hepatic Apoptosis and Hepatocarcinogenesis by Targeting PDCD4

In an acetaminophen (APAP)-induced acute hepatic injury model, hepatocyte-specific miR-199a-3p knockout aggravated hepatic apoptosis.
[Oncogenesis]
Li, Z., Zhou, Y., Zhang, L., Jia, K., Wang, S., Wang, M., Li, N., Yu, Y., Cao, X., & Hou, J. (2020). microRNA-199a-3p inhibits hepatic apoptosis and hepatocarcinogenesis by targeting PDCD4. Oncogenesis, 9(10), 1–14. https://doi.org/10.1038/s41389-020-00282-y Cite
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EAG1 Enhances Hepatocellular Carcinoma Proliferation by Modulating SKP2 and Metastasis through Pseudopod Formation

Scientists verified that Ether-à-go-go-1 (EAG1) promoted the proliferation of hepatocellular carcinoma both in vitro and in vivo. It promoted cell cycle progression by inhibiting the ubiquitination of SKP2.
[Oncogene]
Chen, J., Xuan, Z., Song, W., Han, W., Chen, H., Du, Y., Xie, H., Zhao, Y., Zheng, S., & Song, P. (2020). EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01522-6 Cite
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The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma

The authors summarize rapidly emerging clinical data on the promise and challenges of implementing immune checkpoint cascades in hepatocellular carcinoma and discuss the unmet need of biomarkers to predict response or resistance to therapy.
[JAMA Oncology]
Pinter, M., Jain, R. K., & Duda, D. G. (2020). The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review. JAMA Oncology. https://doi.org/10.1001/jamaoncol.2020.3381 Cite
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The miR-30a-5p/CLCF1 Axis Regulates Sorafenib Resistance and Aerobic Glycolysis in Hepatocellular Carcinoma

The aberrant glucose metabolism in cancer cells aerobic glycolysis is associated with resistance to chemotherapeutic agents. Drug-resistance cells and tumors were exposed to sorafenib to establish sorafenib-resistance cell lines and tumors.
[Cell Death & Disease]
Zhang, Z., Tan, X., Luo, J., Yao, H., Si, Z., & Tong, J.-S. (2020). The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03123-3 Cite
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Georgia State Start-Up Awarded NIH Grant To Develop Contrast Agent for Early Detection of Liver Disease

Inlighta Biosciences, LLC, a start-up company led by Jenny Yang, Regents’ Professor of Chemistry at Georgia State University, has been awarded a National Institute of Health grant to accelerate development of a magnetic resonance imaging contrast agent to detect liver fibrosis, formation of scar tissue in the liver caused by alcoholic and non-alcoholic fatty liver disease.
[Georgia State University]
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Epigenetic Silencing of ZIC4 Contributes to Cancer Progression in Hepatocellular Carcinoma

Functionally, zic family member 4 (ZIC4) inhibition facilitated the proliferation, migration, invasion, and epithelial-mesenchymal transition in vitro and in vivo. Conversely, ZIC4 overexpression reduced proliferation and invasiveness of hepatoceullar carcinoma cells.
[Cell Death & Disease]
Chen, W., Tang, D., Tang, D., & Dai, Y. (2020). Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma. Cell Death & Disease, 11(10), 1–11. https://doi.org/10.1038/s41419-020-03109-1 Cite
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YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/C-MET Signaling in Liver Tumorigenesis

In yes-associated protein (YAP)S127A-induced tumorigenesis, a gradual replacement of liver sinusoidal endothelial cells by continuous endothelial cells was associated with dynamic changes in the expression of genes involved in paracrine communication.
[Cancer Research]
Thomann, S., Weiler, S. M. E., Marquard, S., Rose, F., Ball, C. R., Tóth, M., Wei, T., Sticht, C., Fritzsche, S., Roessler, S., Torre, C. D. L., Ryschich, E., Ermakova, O., Mogler, C., Kazdal, D., Gretz, N., Glimm, H., Rempel, E., Schirmacher, P., & Breuhahn, K. (2020). YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0242 Cite
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Nonalcoholic Steatohepatitis: The Role of Peroxisome Proliferator-Activated Receptors

The authors summarize and discuss the current literature on nonalcoholic fatty liver disease (NAFLD) as the liver manifestation of the systemic metabolic syndrome and focuses on the role of peroxisome proliferator-activated receptors in the pathomechanisms as well as in the potential targeting of disease.
[Nature Reviews Gastroenterology & Hepatology]
Francque, S., Szabo, G., Abdelmalek, M. F., Byrne, C. D., Cusi, K., Dufour, J.-F., Roden, M., Sacks, F., & Tacke, F. (2020). Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors. Nature Reviews Gastroenterology & Hepatology, 1–16. https://doi.org/10.1038/s41575-020-00366-5 Cite
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BCL11B Suppresses Tumor Progression and Stem Cell Traits in Hepatocellular Carcinoma by Restoring p53 Signaling Activity

In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
[Cell Death & Disease]
Yang, W.-J., Sun, Y.-F., Jin, A.-L., Lv, L.-H., Zhu, J., Wang, B.-L., Zhou, Y., Zhang, C.-Y., Wang, H., Hu, B., Wang, P.-X., Te, L., Pan, B.-S., Zhou, J., Fan, J., Yang, X.-R., & Guo, W. (2020). BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity. Cell Death & Disease, 11(10), 1–13. https://doi.org/10.1038/s41419-020-03115-3 Cite
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