Mechano-Modulatory Synthetic Niches for Liver Organoid Derivation

Scientists demonstrated the establishment of biopsy-derived human liver organoids without the use of animal components at any step of the process. Their approach opens up exciting perspectives for the establishment of protocols for liver organoid-based regenerative medicine.
[Nature Communications]
Sorrentino, G., Rezakhani, S., Yildiz, E., Nuciforo, S., Heim, M. H., Lutolf, M. P., & Schoonjans, K. (2020). Mechano-modulatory synthetic niches for liver organoid derivation. Nature Communications, 11(1), 3416. https://doi.org/10.1038/s41467-020-17161-0 Cite
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Suppressing DRP1-Mediated Mitochondrial Fission and Mitophagy Increases Mitochondrial Apoptosis of Hepatocellular Carcinoma Cells in the Setting of Hypoxia

Hepatocellular carcinoma (HCC) cells were subjected to hypoxia and then mitophagy was quantified. The role of dynamin-related protein 1 (DRP1) in hypoxia-induced HCC mitophagy was determined
[Oncogenesis]
Lin, X.-H., Qiu, B.-Q., Ma, M., Zhang, R., Hsu, S.-J., Liu, H.-H., … Chen, R.-X. (2020). Suppressing DRP1-mediated mitochondrial fission and mitophagy increases mitochondrial apoptosis of hepatocellular carcinoma cells in the setting of hypoxia. Oncogenesis, 9(7), 1–13. https://doi.org/10.1038/s41389-020-00251-5 Cite
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How Scientific Societies Are Weathering the Pandemic’s Financial Storm

As meetings worldwide have been called off, postponed or moved online because of the pandemic, organizations are trying to weather the cost of cancelling meetings while grappling with the long-term effects that the pandemic could have on their activities and on the research community.
[Nature]
Editorial

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‘I Feel Like I Am Not Welcome’: Medical, Doctoral Students from Abroad Grapple with Uncertainty from New ICE Rules

International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT]
Press Release

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Assembly Biosciences Announces FDA Fast Track Designation Granted to ABI-H2158 for the Treatment of Chronic Hepatitis B Virus Infection

Assembly Biosciences, Inc. have announced that the US FDA has granted Fast Track designation to ABI-H2158 (2158) for the treatment of patients with chronic hepatitis B infection. 2158 is Assembly’s second-generation core inhibitor, which is being evaluated in an ongoing global Phase II trial.
[Assembly Biosciences, Inc.]
Press Release

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Enanta Pharmaceuticals Announces Clinical Trial Progress for EDP-514, its Lead Core Inhibitor for Hepatitis B Virus

Enanta Pharmaceuticals, Inc., a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, has announced advancements in its hepatitis B virus program evaluating EDP-514 across different patient populations.
[Enanta Pharmaceuticals, Inc.]
Press Release

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Mechano-Modulatory Synthetic Niches for Liver Organoid Derivation

Scientists demonstrated the establishment of biopsy-derived human liver organoids without the use of animal components at any step of the process. Their approach opens up exciting perspectives for the establishment of protocols for liver organoid-based regenerative medicine.
[Nature Communications]
Sorrentino, G., Rezakhani, S., Yildiz, E., Nuciforo, S., Heim, M. H., Lutolf, M. P., & Schoonjans, K. (2020). Mechano-modulatory synthetic niches for liver organoid derivation. Nature Communications, 11(1), 3416. https://doi.org/10.1038/s41467-020-17161-0 Cite
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‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
[Science]
Editorial

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The Emerging Role of Ferroptosis in Non-Cancer Liver Diseases: Hype or Increasing Hope?

Researchers summarize the central molecular machinery of ferroptosis, describe the role of ferroptosis in non-cancer hepatic disease conditions and discuss the potential to manipulate ferroptosis as a therapeutic strategy.
[Cell Death & Disease]
The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope? | Cell Death & Disease. (n.d.). Retrieved July 9, 2020, from https://www.nature.com/articles/s41419-020-2732-5 Cite
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Celastrol Inhibits Ezrin-Mediated Migration of Hepatocellular Carcinoma Cells

Scientists showed that ROCK2 is a novel target of celastrol and inhibition of ROCK2 suppressed elicited ezrin activation and liver cancer cell migration.
[Scientific Reports]
Du, S., Song, X., Li, Y., Cao, Y., Chu, F., Durojaye, O. A., … Ding, X. (2020). Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells. Scientific Reports, 10(1), 11273. https://doi.org/10.1038/s41598-020-68238-1 Cite
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US Bars International Students from Online-Only Learning in Fall

Since higher education institutions ended in-person classes in March due to the COVID-19 pandemic, there has been uncertainty over what classes will look like in the fall. Universities will soon have to come up with an answer.
[The Scientist]
Editorial

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SLC46A1 Contributes to Hepatic Iron Metabolism by Importing Heme in Hepatocytes

The recombinant adeno-associated virus vectors were used to hepatic-specifically inhibit SLC46A1 expression to observe its effects on hepatic iron metabolism. The abilities of SLC46A1 in importing heme and folate, and consequent alterations of iron content in hepatocytes were determined and effects of iron on SLC46A1 expression were investigated both in vitro and in vivo.
[Metabolism-Clinical and Experimental]
Li, H., Wang, D., Wu, H., Shen, H., Lv, D., Zhang, Y., … Li, M. (2020). SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes. Metabolism, 154306. https://doi.org/10.1016/j.metabol.2020.154306 Cite
Abstract

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