Investigators found hepatic lipocalin 2 (LCN2) expression and serum LCN2 level markedly increased and correlated with disease severity and portal hypertension in patients with alcoholic hepatitis.
6445212 8998GYPK items 1 apa default asc 1
Investigators provide succinct insights into the molecular mechanisms responsible for lipotoxicity in non-alcoholic fatty liver disease (NAFLD), including ER and oxidative stress, autophagy, lipoapotosis and inflammation. They highlight the role of CD36/FAT fatty acid translocase in NAFLD pathogenesis.
[Cell Death & Disease]
The authors highlight how insights into hepatocyte regeneration and biology in vivo can inform in vitro studies to propagate primary hepatocytes with signals in liver regeneration and to generate hepatocytes de novo from pluripotent stem cells.
[Cellular and Molecular Gastroenterology and Hepatology]
6445212 ZLTIK677 items 1 apa default asc 1
In this study, scientists knocked down the NSUN2 gene in HepG2 cells by CRISPR/Cas9 technology and performed high-throughput RNA-BisSeq. An important tumor-related lncRNA H19 was identified to be targeted by NSUN2.
6630899 X55CFMHV items 1 apa default asc 1
Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
6630899 3JECYCPJ items 1 apa default asc 1
Investigators evaluated in vitro the expression and the biological function of DCLK1 in intrahepatic cholangiocarcinom (CCA) and perihilar CCA.
6445212 CXQ899RD items 1 apa default asc 1
Nevi, L., Matteo, S. D., Carpino, G., Zizzari, I., Safarikia, S., Ambrosino, V., Costantini, D., Overi, D., Giancotti, A., Monti, M., Bosco, D., Peppo, V. D., Oddi, A., Rose, A. M. D., Melandro, F., Bragazzi, M. C., Faccioli, J., Massironi, S., Grazi, G. L., … Alvaro, D. (n.d.). DCLK1, a putative novel stem cell marker in human cholangiocarcinoma. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31571 Cite
The hepatocellular carcinoma ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages.
6445212 UD3L53YC items 1 apa default asc 1
Sharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., Erdal, S., Teo, H. M., Khalilnezhad, A., Chakarov, S., Lim, T. K. H., Fui, A. C. Y., Chieh, A. K. W., Chung, C. P., Bonney, G. K., … DasGupta, R. (2020). Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.08.040 Cite
Scientists determined that phosphate and tensin homology deleted on chromosome ten (PTEN) deficiency promoted protein synthesis and proteasome subunit expression and proteolytic activity, creating a dependency on the proteasome for cancer cell growth and survival.
[Science Translational Medicine]
Investigators performed immunoprecipitation-mass spectrometry analysis of hepatocellular carcinoma (HCC) tissues. A vital oncoprotein, Y-box binding protein 1 (YB-1), was shown to interact with β2-adrenergic receptor (β2-AR) in HCC cells.
IL-1α was sufficient to activate cultured fibroblasts and primary hepatic stellate cells in vitro, and IL-1α was elevated in the sera and liver of cachectic, suggesting a mechanism by which chronic IL-1R signaling could be leading to cachexia-associated fibrosis.
GENFIT are a late-stage biopharmaceutical company dedicated to improving the lives of patients with metabolic and liver diseases. They have announced the first patient first visit for ELATIVE, the global, pivotal, Phase III study evaluating elafibranor in Primary Biliary Cholangitis (PBC).