Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Acid-Sensing Ion Channel 1a Promotes Alcohol-Associated Liver Disease in Mice via Regulating Endoplasmic Reticulum Autophagy

November 28, 2024

[Acta Pharmacologica Sinica] A mouse model of alcohol-associated liver disease was established using the Gao-Binge method and the AML12 cell line treated with alcohol was used as an in vitro model.

Intestine Epithelial–Specific Hypoxia-Inducible Factor-1α Overexpression Ameliorates Western Diet–Induced MASLD

November 28, 2024

[Hepatology Communications] Metabolic effects of pharmacological activation of hypoxia-inducible factor-1α (HIF-1α) by dimethyloxalylglycine were evaluated in HIF-α luciferase reporter mice.

Myofibroblast-Derived Extracellular Vesicles Facilitate Cancer Stemness of Hepatocellular Carcinoma via Transferring ITGA5 to Tumor Cells

November 22, 2024

[Molecular Cancer] Digital scanning and analysis of the HCC tissue microarray were performed to locate the distribution of integrin α5 (ITGA5) and conduct the prognosis analysis.

PNPLA3(148M) Is a Gain-of-Function Mutation That Promotes Hepatic Steatosis by Inhibiting ATGL-Mediated Triglyceride Hydrolysis

November 22, 2024

[Journal of Hepatology] The authors quantified and compared the physical interactions between α/β hydrolase domain containing protein 5 and patatin-like phospholipase domain-containing protein 3 (PNPLA3)/adipose TG lipase (ATGL) in cultured hepatocytes using NanoBiT complementation assays and immunocytochemistry.

N6-Methyladenosine Modification of Circular RNA circASH2L Suppresses Growth and Metastasis in Hepatocellular Carcinoma through Regulating Hsa-miR-525-3p/MTUS2 Axis

November 22, 2024

[Journal of Translational Medicine] Bioinformatics techniques were used to identify differentially expressed circRNAs in HCC. CircASH2L expression in HCC tissues was assessed through qRT-PCR and in situ hybridization analysis.

Liver Metabolism in Human MASLD: A Review of Recent Advancements Using Human Tissue Metabolomics

November 22, 2024

[Atherosclerosis] The authors review recent metabolomics studies in liver tissue from human MASLD patients, which have predominately focused on lipid metabolism, but also include bile acid, tricarboxylic acid cycle, and branched chain amino acid metabolism.

American Liver Foundation Honors Professor of Medicine Jacquelyn J. Maher, MD with the Distinguished Scientific Achievement Award

November 22, 2024

[American Liver Foundation] American Liver Foundation announced that Dr. Jacquelyn Maher is the winner of its 2024 Distinguished Scientific Achievement Award for her research contributions regarding NAFLD and mechanisms of liver cell toxicity.

Identification of Chikusetsusaponin IVa as a Novel Lysine-Specific Demethylase 1 Inhibitor That Ameliorates High Fat Diet-Induced MASLD in Mice

November 21, 2024

[Acta Pharmacologica Sinica] Researchers investigated the beneficial effects of chikusetsusaponin IVa (CHS) on metabolic dysfunction steatotic liver disease (MASLD) and the underlying mechanisms. MAFLD mouse model was established by the high-fat diet for 6 weeks and then were treated with CHS for another 8 weeks.

β-Catenin Disruption Decreases Macrophage Exosomal α-SNAP and Impedes Treg Differentiation in Acute Liver Injury

November 19, 2024

[JCI Insight] Scientists found that the hepatic Treg proportion and β-catenin expression in hepatic macrophages were associated with acetaminophen and D-galactosamine/ lipopolysaccharide-induced acute liver injury.

DSN1 Interaction with Centromere-Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma

November 19, 2024

[Molecular Carcinogenesis] Researchers utilized The Cancer Genome Atlas, the HCC Cell Database, and other databases to analyze dosage suppressor of NNF1 (DSN1) expression and prognosis in samples from patients with HCC.

SLC1A3 Is a Novel Prognostic Biomarker Associated with Immunity and EMT in Hepatocellular Carcinoma

November 19, 2024

[Discover Oncology] Investigators examined the levels of solute carrier family 1 member 3 (SLC1A3) within HCC and its implications on immunological and epithelial–mesenchymal transition features using the TCGA, ImmPort, and Molecular Signatures databases.

MIST1 Regulates Endoplasmic Reticulum Stress-Induced Hepatic Apoptosis as a Candidate Marker of Fatty Liver Disease Progression

November 15, 2024

Scientists investigated the dynamics of gene expression associated with the progression of liver disease. They analyzed changes in gene expression over time in a...

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!