Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Acquisition of Epithelial Plasticity in Human Chronic Liver Disease

[Nature] Investigators performed single-nucleus RNA sequencing on 47 liver biopsies from patients with different stages of metabolic dysfunction-associated steatotic liver disease to establish a cellular map of the liver during disease progression.

Neutrophil Extracellular Traps Activate Hepatic Stellate Cells and Monocytes via NLRP3 Sensing in Alcohol-Induced Acceleration of MASH Fibrosis

[Gut] Researchers found that alcohol binges in MASH increased liver injury and fibrosis. Liver transcriptomic profiling revealed differential expression of genes involved in extracellular matrix reorganisation, neutrophil activation and inflammation compared with alcohol or the MASH diet alone.

Angiocrine Signaling in Sinusoidal Homeostasis and Liver Diseases

[Journal of Hepatology] Scientists summarize the crosstalk between liver sinusoidal endothelial cells, HSCs, hepatocytes, cholangiocytes, and immune cells in health and disease and comment on potential novel therapeutic methods for treating liver diseases.

New Funding Provided for Research into Fatty Liver Disease at UT Health and for New Building

[Texas Public Radio] University of Texas (UT) School of Public Health San Antonio received nearly $3 million in new funding on May 20th. Almost $2 million will go into research for hepatic steatosis, commonly known as fatty liver disease.

Comprehensive Prognostic and Immunological Analysis of Cullin2 in Pan-Cancer and Its Identification in Hepatocellular Carcinoma

[Aging] Various databases were applied to observe the CUL2 expression. Kaplan-Meier and Spearman correlation analyses were employed to investigate the potential links between CUL2 level, patient prognosis, and the infiltration of immune cells.

Establishment of Homotrimer Collagen Type I Signature and Its Association with Clinical Manifestation and Tertiary Lymphoid Structures Formation in Liver Cancer

[Heliyon] Using transcriptional and immunoflourance method, investigators established homocol signautre, which was able to transcriptionally and histologically detect homotrimeric collagen type I.

hiPSC-Derived Macrophages Improve Drug Sensitivity and Selectivity in a Macrophage-Incorporating Organoid Culture Model

[Biofabrication] Researchers created macrophage-containing organoid co-culture models by directly incorporating hiPSC-derived pre-macrophages into organoid and scaffold cell models.

Reproducible Generation of Human Liver Organoids (HLOs) on a Pillar Plate Platform via Microarray 3D Bioprinting

[Lab On A Chip] Microarray 3D bioprinting, a droplet-based printing technology, was used to generate a large number of small organoids on the pillar plate for predictive hepatotoxicity assays.

Adipocyte HSL Is Required for Maintaining Circulating Vitamin A and RBP4 Levels During Fasting

[EMBO Reports] Investigators showed that fasting affected retinoid mobilization in a tissue-specific manner, and that hormone-sensitive lipase in adipose tissue is required to maintain serum concentrations of retinol and RBP4 during fasting in mice.

CBX1 Is Involved in Hepatocellular Carcinoma Progression and Resistance to Sorafenib and Lenvatinib via IGF-1R/AKT/SNAIL Signaling Pathway

[Hepatology International] Bioinformatics approaches were harnessed to scrutinize Chromobox Homolog 1's (CBX1’s) expression profile, its association with tumor staging, and its potential impact on patient outcomes across various cancers.

CD47, a Novel YAP Target Gene, Contributes to Hepatic Stellate Cell Activation and Liver Fibrosis Induced by High-Fat Diet

[Heliyon] The authors employed single-cell RNA sequencing analysis to investigate CD47 expression in HSCs from mice subjected to a high-fat diet. CD47 silencing in HSCs markedly inhibited the expression of fibrotic genes and promoted apoptosis.

m6A Demethylation of FOSL1 mRNA Protects Hepatoma Cells against Necrosis Under Glucose Deprivation

[Cell Death & Differentiation] Scientists found that glucose deprivation reduced m6A modification levels. Increasing m6A modification resulted in increased hepatoma cell necrosis under glucose deprivation, whereas decreasing m6A modification had an opposite effect.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!