Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

SCARB2 Drives Hepatocellular Carcinoma Tumor Initiating Cells via Enhanced MYC Transcriptional Activity

[Nature Communications] Scientists performed a metabolic gene CRISPR/Cas9 knockout library screen in tumorspheres derived from HCC cells and found that deletion of scavenger receptor class B member 2 (SCARB2) suppressed the cancer stem cell-like properties of HCC cells.

Adenosine A2A Receptor Is a Tumor Suppressor of NASH-Associated Hepatocellular Carcinoma

[Cell Reports Medicine] Researchers reported that anti-obesogenic and anti-inflammatory functions of adenosine A2A receptor significantly restrain HCC development. Adora2a deletion in mice triggered obesity, non-alcoholic steatohepatitis (NASH), and systemic inflammation.

Combination of an ACLY Inhibitor with a GLP-1R Agonist Exerts Additive Benefits on Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Mice

[Cell Reports Medicine] Investigators found that combining an inhibitor of liver ATP citrate lyase (ACLY), bempedoic acid, and the GLP-1R agonist liraglutide reduced liver steatosis, hepatocellular ballooning, and hepatic fibrosis in a mouse model of nonalcoholic steatohepatitis.

METTL5-Mediated 18S rRNA m6A Modification Promotes Oncogenic mRNA Translation and Intrahepatic Cholangiocarcinoma Progression

[Molecular Therapy] Investigators found that 18S rRNA m6A modification and its methyltransferase METTL5 were aberrantly upregulated in intrahepatic cholangiocarcinoma and associated with poorer survival.

An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

[eLife] Investigators reported a fundamental and unexpected role of neutrophils as the predominant phagocyte responsible for the clearance of apoptotic hepatic cells in the steady state.

LncRNA Tug1 Relieves the Steatosis of SelenoF-Knockout Hepatocytes via Sponging miR-1934-3p

[Cell Biology And Toxicology] The authors uncovered that the potent non-coding RNA Tug1, which was related to metabolic enzymes, regulated hepatocytes steatosis induced by sodium palmitate via miR-1934-3p absorbing.

First Wilson Disease Patient Receives Gene Therapy at UC Davis Health

[UC Davis Health] Researchers at UC Davis Health have infused their first Wilson Disease patient with a gene therapy as part of a groundbreaking new clinical trial. The treatment has the potential to address the underlying cause of the disease.

ARF6 Promotes Hepatocellular Carcinoma Proliferation through Activating STAT3 Signaling

[Cancer Cell International] Immunohistochemistry and western blotting were used to detect the expression level of ADP ribosylation factor 6 (ARF6) in HCC tissues. Investigators analyzed the clinical significance of ARF6 in primary HCC patients.

HSDL2 Knockdown Promotes the Progression of Cholangiocarcinoma by Inhibiting Ferroptosis through the P53/SLC7A11 Axis

[World Journal of Surgical Oncology] Human hydroxysteroid dehydrogenase-like 2 (HSDL2) expression levels in cholangiocarcinoma cells and tissues were determined by quantitative real-time polymerase chain reaction, western blotting, and immunohistochemistry.

Enhancing HCC Treatment: Innovatively Combining HDAC2 Inhibitor with PD-1/PD-L1 Inhibition

[Cancer Cell International] The authors review the application of ideal histone deacetylases 2 (HDAC2) inhibitors with solid anti-tumor efficacy in combination with immunotherapy for HCC.

Therapeutic Blockade of ER Stress and Inflammation Prevents NASH and Progression to HCC

[Science Advances] Scientists used single-nucleus RNA sequencing to characterize a mouse model that mimicked human nonalcoholic steatohepatitis (NASH)–driven HCC, the MUP-uPA mouse fed a high-fat diet.

Direct Mechanical Exposure Initiates Hepatocyte Proliferation

[JHEP Reports] Mouse liver perfusion was used to identify the effects of interstitial flow on hepatocyte proliferation ex vivo. Isolated hepatocytes in vitro were further exposed to varied shear stresses directly.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!