Scientists explored the efficacy of two protocols to decellularize porcine liver tissue using varying combinations of commonly used chemical agents such as Triton X-100, Sodium Dodecyl Sulphate and ammonium hydroxide.
[Scientific Reports]
Category Archives: Hepatic Cell
Hepatic Cell NewsHepatic Cell News is an online publication and email newsletter covering the top research on hepatocytes and liver diseases.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. The newsletter covers areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
Photocrosslinkable Liver Extracellular Matrix Hydrogels for the Generation of 3D Liver Microenvironment Models
Multi-Disciplinary Clinic Models: A Paradigm of Care for Management of Non-alcoholic Fatty Liver Disease (NAFLD)
Metabolic Hallmarks of Liver Regeneration
The authors highlight how lipids, carbohydrates, and proteins dynamically change and orchestrate liver regeneration. They discuss translational studies in which metabolic intervention has been used to treat chronic liver diseases.
[Trends in Endocrinology and Metabolism]
The Immunological and Metabolic Landscape in Primary and Metastatic Liver Cancer
Researchers discuss how the hepatic microenvironment adapts to pathologies characterized by chronic inflammation and metabolic alterations. They illustrate how these immunological or metabolic changes alter immunosurveillance and thus hinder or promote the development of primary liver cancer.
[Nature Reviews Cancer]
Arrowhead Pharmaceuticals Receives Breakthrough Therapy Designation from US FDA for ARO-AAT for the Treatment of Alpha-1 Antitrypsin Deficiency Associated Liver Disease
Arrowhead Pharmaceuticals, Inc. announced that it was granted Breakthrough Therapy designation by the US FDA for ARO-AAT, also known as TAK-999, the company’s second-generation investigational RNA interference therapeutic being co-developed with Takeda Pharmaceutical Company Limited as a treatment for the rare genetic liver disease associated with alpha-1 antitrypsin deficiency.
[Arrowhead Pharmaceuticals, Inc. (BusinessWire, Inc.)]
Downregulation of TMEM220 Promotes Tumor Progression in Hepatocellular Carcinoma
Super Enhancer Regulation of Cytokine-Induced Chemokine Production in Alcoholic Hepatitis
Researchers explored the mechanistic role of super-enhancers linking cytokine TNFα with chemokine amplification in alcoholic hepatitis.
[Nature Communications]
TRIB2 Desensitizes Ferroptosis via βTrCP-Mediated TFRC Ubiquitiantion in Liver Cancer Cells
Scientists identified the role of tribbles homolog 2 (TRIB2) to relieve oxidative damage via reducing the availability of ubiquitin that was essential for the ubiquitination and subsequent degradation of glutathione peroxidase 4.
[Cell Death Discovery]
Low Serum Magnesium Concentration Is Associated with the Presence of Viable Hepatocellular Carcinoma Tissue in Cirrhotic Patients
In a subset of 94 patients with hepatocellular carcinoma (HCC), a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor.
[Scientific Reports]
BH3-Only Protein Expression Determines Hepatocellular Carcinoma Response to Sorafenib-Based Treatment
In the presence of NOXA, BIM-deficient hepatocellular carcinoma cells could be in turn strongly sensitized for cell death induction by the combination of sorafenib with TNF-related apoptosis-inducing ligand .
[Cell Death & Disease]
SMYD3 Promotes Hepatocellular Carcinoma Progression by Methylating S1PR1 Promoters
Researchers reported that SET and MYND domain-containing protein 3 (SMYD3) expression in hepatocellular carcinoma (HCC) was an independent prognostic factor for survival and promoted the proliferation and migration of HCC cells.
[Cell Death & Disease]
