Hepatic Cell News | Science News

In Vitro Grafting of Hepatic Spheroids and Organoids on a Microfluidic Vascular Bed

June 24, 2022

[Angiogenesis] The authors introduced a platform for routine grafting of liver and other tissues on an in vitro grown microvascular bed. The platform consisted of 64 microfluidic chips patterned underneath a 384-well microtiter plate.

Apolipoprotein F Is Reduced in Humans with Steatosis and Controls Plasma Triglyceride-Rich Lipoprotein Metabolism

June 24, 2022

[Hepatology] To identify liver-regulated pathways linking intra-hepatic and plasma triglyceride metabolism, scientists performed transcriptomic analysis of liver biopsies from two independent cohorts of obese patients.

A Randomized, Placebo-Controlled Clinical Trial of Hydrogen/Oxygen Inhalation for Non-Alcoholic Fatty Liver Disease

June 24, 2022

[Journal of Cellular and Molecular Medicine] Researchers investigated the effect of hydrogen/oxygen inhalation on non-alcoholic fatty liver disease subjects and explored the mechanism from the perspective of hepatocyte autophagy.

Proteomic Analysis Reveals USP7 as a Novel Regulator of Palmitic Acid-Induced Hepatocellular Carcinoma Cell Death

June 24, 2022

[Cell Death & Disease] Scientists used a proteomics approach to circumvent the mechanism for lipotoxicity using hepatocellular carcinoma cells as a model.

ANKFN1 Plays Both Protumorigenic and Metastatic Roles in Hepatocellular Carcinoma

June 24, 2022

[Oncogene] Silencing ANKFN1 expression suppressed HCC cell proliferation, migration, invasion, and metastasis in vitro and subcutaneous tumorigenesis in vivo.

FoxO3 Restricts Liver Regeneration by Suppressing the Proliferation of Hepatocytes

June 24, 2022

[NPJ Regenerative Medicine] The authors demonstrated that FoxO3 deletion accelerated liver regeneration primarily by limiting polyploidization and promoting the proliferation of hepatocytes during liver regeneration.

Polygonum Multiflorum Thunb. Induces Hepatotoxicity in SD Rats and Hepatocyte Spheroids by Disrupting the Metabolism of Bilirubin and Bile Acid

June 24, 2022

[Journal of Ethnopharmacology] The manifestations of liver injury triggered by P. multiflorum and the associated metabolic enzymes/transporters in the metabolic pathways of bilirubin and bile acid were investigated to elucidate the mechanism and target of the hepatotoxicity of P. multiflorum and related components.

Hepatic Encephalopathy

June 24, 2022

[Nature Reviews Disease Primers] Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease. Severity classification and diagnostic approaches regarding mild forms of HE are still a matter of debate.

Echosens and Novo Nordisk Announce Partnership to Increase Awareness and Advance Early Diagnosis of NASH

June 24, 2022

[Echosens] Echosens and Novo Nordisk A/S announced a partnership to advance early diagnosis of non-alcoholic steatohepatitis (NASH) and increase awareness of the disease among patients, healthcare providers, and other stakeholders.

Apolipoprotein F Is Reduced in Humans with Steatosis and Controls Plasma Triglyceride-Rich Lipoprotein Metabolism

June 23, 2022

[Hepatology] To identify liver-regulated pathways linking intra-hepatic and plasma triglyceride metabolism, scientists performed transcriptomic analysis of liver biopsies from two independent cohorts of obese patients.

A Randomized, Placebo-Controlled Clinical Trial of Hydrogen/Oxygen Inhalation for Non-Alcoholic Fatty Liver Disease

June 23, 2022

[Journal of Cellular and Molecular Medicine] Researchers investigated the effect of hydrogen/oxygen inhalation on non-alcoholic fatty liver disease subjects and explored the mechanism from the perspective of hepatocyte autophagy.

Proteomic Analysis Reveals USP7 as a Novel Regulator of Palmitic Acid-Induced Hepatocellular Carcinoma Cell Death

June 23, 2022

[Cell Death & Disease] Scientists used the proteomics approach to circumvent the mechanism for lipotoxicity using hepatocellular carcinoma cells as a model.