Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Dual-Targeting Macrophages and Hepatic Stellate Cells by Modified Albumin Nanoparticles for Liver Cirrhosis Treatment

[ACS Applied Materials & Interfaces] Researchers developed a novel modified nanoparticle system in which Sorafenib was encapsulated by palmitic acid-modified albumin and further modified with chondroitin sulfate.

Regulatory T Cell: A Double-Edged Sword From Metabolic-Dysfunction-Associated Steatohepatitis to Hepatocellular Carcinoma

[eBioMedicine] Recent studies have unveiled distinct behaviors of Tregs at different stages of metabolic-dysfunction-associated steatotic liver disease (MASLD), suggesting a dual role in the pathogenesis. The authors explore the fate of Tregs from MASLD to HCC, offering recent insights into potential targets for clinical intervention.

‘There’s Still A Long Way To Go’: Wei Zhang, MD, PhD, on Stigmatizing Language in Liver Transplant Centers

[HCPLive] Although stigmatizing language for substance use disorders has emerged as a major topic of concern across multiple fields in recent years, in many instances, recommendations from medical societies advocating for patient-centered language have not been implemented in practice.

Multi-Million Dollar Federal Grant Creates New Drug Discovery Center at Pitt

[University of Pittsburgh] Liver disease researchers and clinicians at the University of Pittsburgh School of Medicine and UPMC will use a $7.8 million grant to create a new drug discovery center called the Pitt Translational Center for Microphysiology Systems.

SOCS5-RBMX Stimulates SREBP1-Mediated Lipogenesis to Promote Metastasis in Steatotic HCC ith HBV-Related Cirrhosis

[NPJ Precision Oncology] Hematoxylin-eosin staining of 245 HCC samples revealed a special HCC subtype characterized by HBV-related cirrhosis and intratumoral steatosis without fatty liver background, defined as steatotic HCC with HBV-related cirrhosis.

Differential Responses of Hepatopancreas Transcriptome Between Fast and Slow Growth in Giant Freshwater Prawns (Macrobrachium rosenbergii) Fed a Plant-Based Diet

[Scientific Reports] Two hundred shrimp were fed SBM for 90 days, and specific growth rate was determined individually. Fast- and slow-growing shrimp, with the highest and lowest 5% SGRs, respectively, were sampled to determine haemolymph chemistry and carcass composition.

miR-548ag Promotes DPP4 Expression in Hepatocytes Through Activation of TLR(7/8)/NF-κB Pathway

[International Journal Of Obesity] Male C57BL/6J mice were fed normal chow diet or high-fat diet (HFD) for 12 weeks. For a duration of six weeks, NCD mice received intraperitoneal injections of a miR-548ag mimic, while HFD mice and db/db mice were administered intraperitoneal injections of a miR-548ag inhibitor.

A Spatial Map of Hepatic Mitochondria Uncovers Functional Heterogeneity Shaped by Nutrient-Sensing Signaling

[Nature Communications] The authors combineed intravital microscopy, spatial proteomics, and functional assessment to investigate mitochondrial heterogeneity in the context of liver zonation.

A Neuroligin-2-YAP Axis Regulates Progression of Pancreatic Intraepithelial Neoplasia

[Advanced Materials] Researchers successfully engineered an adenosine 5′-triphosphate-responsive manganese-based bacterial material that exhibitd an exceptional ability to synergistically activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING pathway.

Serum Amyloid a Promotes Glycolysis of Neutrophils During PD-1 Blockade Resistance in Hepatocellular Carcinoma

[Nature Communications] Investigators utilized a panel of 16 serum factors to show that a circulating level of serum amyloid A  > 20.0 mg/L has the highest accuracy in predicting anti-PD-1 resistance in hepatocellular carcinoma.

TET1 Inhibits Liver Fibrosis by Blocking Hepatic Stellate Cell Activation

[Journal Of Gastroenterology And Hepatology] Scientists investigated that the involvement of hydroxymethylase ten–eleven translocation 1 (TET1) in HSC activation and liver fibrosis. It was revealed that TET1 levels were downregulated in the livers in mouse models of liver fibrosis and patients with cirrhosis, as well as activated HSCs in comparison to quiescent HSCs.

KIF18A Inactivates Hepatic Stellate Cells and Alleviates Liver Fibrosis through the TTC3/Akt/mTOR Pathway

[Cellular And Molecular Life Sciences] Researchers observed a decrease in the expression of KIF18A in fibrotic liver tissues compared to healthy liver tissues, which exhibited a negative correlation with the activation of HSCs.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

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