Category Archives: Hepatic Cell

Hepatic Cell News is an online publication and email newsletter covering the top research on hepatocytes and liver diseases.
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The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. The newsletter covers areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

SMYD3 Promotes Hepatocellular Carcinoma Progression by Methylating S1PR1 Promoters

Researchers reported that SET and MYND domain-containing protein 3 (SMYD3) expression in hepatocellular carcinoma (HCC) was an independent prognostic factor for survival and promoted the proliferation and migration of HCC cells.
[Cell Death & Disease]
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Eureka Therapeutics Announces Initiation of Phase I/II ARYA-3 Clinical Trial of GPC3 Targeting ARTEMIS® T Cell Therapy in Liver Cancer

Eureka Therapeutics, Inc. announced the initiation of a Phase I/II clinical trial of ECT204, a GPC3 targeting ARTEMIS® T-cell therapy for the treatment of hepatocellular carcinoma, the predominant type of liver cancer.
[Eureka Therapeutics, Inc.]
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Use of Human Tissue Stem Cell-Derived Organoid Cultures to Model Enterohepatic Circulation

Researchers demonstrated that mature stem cell-derived intestinal and liver organoid cultures each express functional molecules that modulate bile acid uptake and recycling.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Blutt, S. E., Crawford, S., Bomidi, C., Zeng, X.-L., Broughman, J., Robertson, M., Coarfa, C., Tessier, M. E., Savidge, T. C., Hollinger, F. B., Curley, S., Donowitz, M., & Estes, M. K. (2021). Use of Human Tissue Stem Cell-Derived Organoid Cultures to Model Enterohepatic Circulation. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00177.2021 Cite
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CD8+ Tissue-Resident Memory T Cells Promote Liver Fibrosis Resolution by Inducing Apoptosis of Hepatic Stellate Cells

Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103−CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.
[Nature Communications]
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Circular Noncoding RNA hsa_circ_0005986 as a Prognostic Biomarker for Hepatocellular Carcinoma

Scientists evaluated the expression of a recently identified circRNA, hsa_circ_0005986; determineD its clinical significance; and evaluateD its potential as a biomarker of hepatocellular carcinoma.
[Scientific Reports]
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Modeling Alcohol-Associated Liver Disease in a Human Liver-Chip

Investigators leveraged a triculture human Liver-Chip with biomimetic hepatic sinusoids and bile canaliculi to model ALD employing human-relevant blood alcohol concentrations and multimodal profiling of clinically relevant endpoints.
[Cell Reports]
Nawroth, J. C., Petropolis, D. B., Manatakis, D. V., Maulana, T. I., Burchett, G., Schlünder, K., Witt, A., Shukla, A., Kodella, K., Ronxhi, J., Kulkarni, G., Hamilton, G., Seki, E., Lu, S., & Karalis, K. C. (2021). Modeling alcohol-associated liver disease in a human Liver-Chip. Cell Reports, 36(3). https://doi.org/10.1016/j.celrep.2021.109393 Cite
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Dynamin-Related Protein 1 Deficiency Accelerates Lipopolysaccharide-Induced Acute Liver Injury and Inflammation in Mice

Researchers hypothesized that dynamin-related protein 1 defects were a causal factor directly involved in liver disease development and stimulated liver disease progression.
[Communications Biology]
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PPM1G Promotes the Progression of Hepatocellular Carcinoma via Phosphorylation Regulation of Alternative Splicing Protein SRSF3

Scientists showed that the PPM1G, a protein phosphatase, regulated the phosphorylation of SRSF3 in hepatocellular carcinoma (HCC) and contributed to the proliferation, invasion, and metastasis of HCC.
[Cell Death & Disease]
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EGFR Activation Limits the Response of Liver Cancer to Lenvatinib

The combination of the epidermal growth factor receptor (EGFR) inhibitor gefitinib and lenvatinib displayed potent anti-proliferative effects in vitro in liver cancer cell lines that expressed EGFR.
[Nature]
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The Aetiology and Molecular Landscape of Insulin Resistance

Scientists hypothesized that deregulation in the maintenance of the pool of coenzyme A might play a crucial role in the pathogenesis of nonalcoholic fatty liver disease.
[Experimental and Molecular Medicine]
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Bromodomain-Containing Protein BRPF1 Is a Therapeutic Target for Liver Cancer

Gene ablation or pharmacological inactivation of BRPF1 (bromodomain and PHD finger containing 1) significantly attenuated hepatocellular carcinoma cell growth in vitro and in vivo.
[Communications Biology]
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