The authors explored whether rapid evaporative ionization mass spectrometry lipid patterns ccould identify human liver tumors and improve the rapid characterization of their underlying metabolic features.
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Scientists found that recombinant EREG, BTC, and NRG1 but not Lgr5 ligand R-Spondin promoted growth and proliferation of Apc double mutant colonic organoids.
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Westendorp, F., Karpus, O. N., Koelink, P. J., Vermeulen, J. L. M., Meisner, S., Koster, J., Büller, N. V. J. A., Wildenberg, M. E., Muncan, V., & van den Brink, G. R. (2021). Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01633-0 Cite
Hepatocellular carcinom cell lines and a xenograft mouse model with resistance to sorafenib were employed to analyze the effects of miR424 on cancer stem cell characteristics.
[British Journal of Cancer]
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EMBO has announced the award of Installation Grants to eight scientists in the early stages of setting up their independent laboratories in Lithuania, Poland, Portugal and Turkey.
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The structural information of the insulin-like growth factor 2 receptor (IGF2R), an overexpressed protein on activated hepatic stellate cells, were used for an in silico screening of novel IGF2R-specific peptide ligands.
[Journal of Materials Chemistry B]
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Weber, F., Casalini, T., Valentino, G., Brülisauer, L., Andreas, N., Koeberle, A., Kamradt, T., Contini, A., & Luciani, P. (2021). Targeting transdifferentiated hepatic stellate cells and monitoring the hepatic fibrogenic process by means of IGF2R-specific peptides designed in silico. Journal of Materials Chemistry B. https://doi.org/10.1039/D0TB02372H Cite
Investigators showed that BNIP3 is required for glucagon-induced mitophagy in the liver through interaction with processed LC3B; an interaction that is also necessary to localize LC3B out of the nucleus to cytosolic mitophagosomes in response to nutrient deprivation.
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Springer, M. Z., Poole, L. P., Drake, L. E., Bock-Hughes, A., Boland, M. L., Smith, A. G., Hart, J., Chourasia, A. H., Liu, I., Bozek, G., & Macleod, K. F. (2021). BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2021.1877469 Cite
To understand specific host conditions that affect infectivity, the authors studied Plasmodium falciparum parasite liver stage development in relation to the metabolic heterogeneity of fresh human hepatocytes.
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Yang, A. S. P., van Waardenburg, Y. M., van de Vegte-Bolmer, M., van Gemert, G.-J. A., Graumans, W., de Wilt, J. H. W., & Sauerwein, R. W. (2021). Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites. The EMBO Journal, n/a(n/a), e106583. https://doi.org/10.15252/embj.2020106583 Cite
Scientists consider the benefits, limitations, and adaptations of specific in vitro approaches to assess DNA damage in the liver, whilst identifying critical advancements required to support a multitude of biochemical endpoints.
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Llewellyn, S. V., Niemeijer, M., Nymark, P., Moné, M. J., Water, B. van de, Conway, G. E., Jenkins, G. J. S., & Doak, S. H. (n.d.). In Vitro Three-Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, n/a(n/a), 2006055. https://doi.org/https://doi.org/10.1002/smll.202006055 Cite
Using liver-specific G9a-deficient mice, scientists revealed that loss of G9a significantly attenuated liver tumor initiation caused by diethylnitrosamine.
[Cell Death & Disease]
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Nakatsuka, T., Tateishi, K., Kato, H., Fujiwara, H., Yamamoto, K., Kudo, Y., Nakagawa, H., Tanaka, Y., Ijichi, H., Ikenoue, T., Ishizawa, T., Hasegawa, K., Tachibana, M., Shinkai, Y., & Koike, K. (2021). Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis. Cell Death & Disease, 12(1), 1–13. https://doi.org/10.1038/s41419-020-03381-1 Cite
Researchers investigated the expression of insulin growth factor binding proteins and their role in the generation of human retinal organoids from human pluripotent stem cells.
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IGFBPs mediate IGF‐1’s functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids - Zerti - - STEM CELLS - Wiley Online Library. (n.d.). Retrieved January 15, 2021, from https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3331?af=R Cite
In vitro loss-of-function and gain-of-function analyses suggested that circRNA derived from the Pleckstrin and Sec7 domain-containing 3 (circPSD3) inhibited the activation and proliferation of hepatic stellate cells.
[Molecular Therapy-Nucleic Acids]
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