Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Hepatic MC3R Is a Regulator of Lipid Droplet Autophagy and Liver Steatosis

April 23, 2025

[Autophagy] Scientists reported that global mc3r knockout mice developed obesity with increased hepatic triglyceride accumulation and blunted hepatocellular autophagosome-lysosome docking, leading to defective lipid droplet clearance.

Increased Risk of Hepatocellular Carcinoma in HBeAg-Negative Indeterminate Phase Compared to HBeAg-Negative Chronic Infection

April 23, 2025

[Hepatology] In patients with indeterminate phase HBeAg-negative chronic hepatitis B, those with normal alanine aminotransferase (ALT) and high hepatitis B virus (HBV) DNA showed a higher HCC risk than those with abnormal ALT and low HBV DNA, with no difference between treated and untreated patients in either group.

Intratumoral Self-Assembly of Renal-Clearable Gold Nanoparticles As Precise Photothermal Nanomedicine for Liver Tumor Therapy

April 23, 2025

[Science Advances] Investigators reported a biosafe therapeutic photothermal therapy strategy to treat liver tumors precisely through the intratumoral self-assembly of renal-clearable ultrasmall renal-clearable gold nanoparticles at the tumor site via host-guest interactions.

Construction of Highly Vascularized Hepatic Spheroids of Primary Hepatocytes via Pro-Angiogenic Strategy In Vitro

April 22, 2025

[Biofabrication] Scientists achieved vascularization of hepatic spheroids containing freshly isolated primary hepatocytes by incorporating fibroblasts as a source of paracrine factors to induce angiogenesis.

PPARα Regulates ER-Lipid Droplet Protein Calsyntenin-3β to Promote Ketogenesis in Hepatocytes

April 22, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that Clstn3b expression was induced in the liver by the nuclear receptor PPARα in settings of high lipid utilization, including fasting and ketogenic diet feeding.

Pregnane X Receptor Alleviates Sepsis-Induced Liver Injury through Activation of Yes-Associated Protein in Mice

April 17, 2025

[Acta Pharmacologica Sinica] Scientists investigated the role of pregnane X receptor in sepsis-induced liver injury and the underlying mechanisms.

Chronic Intermittent Hypoxia Alleviates Alcohol-Related Liver Injury via Downregulation of Hepatic Hypoxia-Inducible Factor-2α

April 17, 2025

[American Journal of Physiology-Gastrointestinal and Liver Physiology] As an approach to investigate the relationship between alcohol-enhanced obstructive sleep apnea and alcohol-related liver disease (ALD) development/progression in vivo Gao-binge ALD and chronic intermittent hypoxia mouse models were established.

Integrated Liver-Secreted and Plasma Proteomics Identify a Predictive Model That Stratifies MASH

April 17, 2025

[Cell Reports Medicine] Researchers assessed plasma and liver from 266 obese individuals spanning the metabolic-associated steatotic liver disease spectrum. Ninety-six human livers were precision-cut, and mass spectrometry-based proteomics identified 3,333 proteins in the liver-secretion medium, of which 107 were differentially secreted in metabolic-associated steatohepatitis (MASH) compared with no pathology.

HIF-1α/LTBP2 Axis Activate HSCs to Promote Liver Fibrosis by Interacting with LOXL1 via the ERK Pathway

April 17, 2025

[Cellular and Molecular Life Sciences] The authors elucidated the function and mechanism of latent transforming growth factor beta binding protein 2 (LTBP2) in hepatic stellate cells activation and liver fibrosis.

NS3 of Hepatitis C Virus Drives Hepatocellular Carcinoma Progression through a Novel RNA-Interference Pathway

April 15, 2025

[Journal of Cell Communication and Signaling] Researchers employed transcriptome sequencing to explore the role of non-structural protein 3 (NS3) in promoting HCC progression by comparing gene expression profiles between hepatitis C virus-infected HCC tissues and healthy liver controls.

BIRC2 Blockade Facilitates Immunotherapy of Hepatocellular Carcinoma

April 15, 2025

[Molecular Cancer] Genome-wide CRISPR/Cas9 screening was conducted to identify tumor-intrinsic genes pivotal for immune escape. In vitro and in vivo models demonstrated the role of baculoviral IAP repeat-containing protein 2 (BIRC2) in protecting HCC cells from immune killing.

ELANE Enhances KEAP1 Protein Stability and Reduces NRF2-Mediated Ferroptosis Inhibition in Metabolic Dysfunction-Associated Fatty Liver Disease

April 14, 2025

[Cell Death & Disease] Scientists used mice of Elane-knockout and wild-type, and their primary mouse hepatocytes to establish metabolic-associated fatty liver disease (MAFLD) models in vivo and in vitro for elucidating the role of Elane in ferroptosis of hepatocytes and MAFLD development.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!