Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2-SLC7A11 Signaling Pathway

January 24, 2025

[Advanced Science] Scientists observed that Gaudichaudione H enhanced the sensitivity of HCC cells to disulfidptosis, which was dependent on the activation of NRF2-SLC7A11 pathway.

Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease – The Molecular Role of Fatty Acids Versus Sugars in Human Metabolism and Disease Progression

January 24, 2025

[Advances in Nutrition] The authors examine the mechanistic pathways through which dietary fatty acids and sugars contribute the development of hepatic inflammation and fibrosis, offering a nuanced understanding of their respective roles in metabolic dysfunction-associated steatotic liver disease progression.

Metabolic Dysfunction-Associated Steatotic Liver Disease in Children

January 24, 2025

[Gut] Emerging data indicate that steatosis can be present in children under six years of age. The intricate interplay of genetics may inform future therapeutics and prognostication, with the PNPLA3 gene showing the most evidence for association with the risk and severity of steatotic liver disease and steatohepatitis.

TREM2 Promotes the Formation of a Tumor-Supportive Microenvironment in Hepatocellular Carcinoma

January 23, 2025

[Journal of Experimental & Clinical Cancer Research] Researchers investigated the role of triggering receptor expressed on myeloid cells 2 (TREM2+) macrophages in various mouse HCC models. They investigated the role of TREM2+ macrophages in promoting the malignant phenotypes of HCC cells.

Identification of Glycogen Synthase Kinase 3alpha/beta as a Host Factor Required for Hepatitis B Virus Transcription Using High-Throughput Screening

January 23, 2025

[Hepatology] Researchers established a Hepatitis B virus (HBV)-based-reporter gene expression system that mimicked HBV replication from transcription to virus egress. They screened 1,827 FDA-approved compounds and identified glycogen synthase kinase 3alpha/beta inhibitors as anti-HBV compounds.

Targeting Aldolase A in Hepatocellular Carcinoma Leads to Imbalanced Glycolysis and Energy Stress due to Uncontrolled FBP Accumulation

January 21, 2025

[Nature Metabolism] Using functional genomic screening, scientists revealed that liver cancer cells showed a unique sensitivity toward aldolase A (ALDOA) depletion. Targeting glycolysis by disrupting the catalytic activity of ALDOA led to severe energy stress and cell cycle arrest in murine and human hepatocellular carcinoma cell lines.

Nikang Therapeutics® Announces First Patient Dosed in a Phase Ib/II Study of NKT2152 in Combination With Standard-Of-Care in First-Line Regimen for Hepatocellular Carcinoma

January 21, 2025

[NiKang Therapeutics,^® Inc.] NiKang Therapeutics,® Inc. announced that the first patient has been dosed in the global randomized Phase I/II clinical study evaluating NKT2152, a highly potent, selective and orally bioavailable small molecule HIF2α inhibitor, in combination with standard-of-care regimen of atezolizumab and bevacizumab in the first-line treatment of patients with HCC.

SLC13A2 Promotes Hepatocyte Metabolic Remodeling and Liver Regeneration by Enhancing De Novo Cholesterol Biosynthesis

January 20, 2025

[EMBO Journal] Researchers screened metabolic genes differentially regulated during liver regeneration, and reported that sodium-dependent dicarboxylate transporter 1 (SLC13A2), a transporter for the tricarboxylic acid cycle intermediates, was decreased in rapid response to partial hepatectomy in mice and recovered along restoration of liver mass and function.

USP25 Directly Interacts with and Deubiquitinates PPARα to Increase PPARα Stability in Hepatocytes and Attenuate High-Fat Diet-Induced MASLD in Mice

January 20, 2025

[Cell Death & Differentiation] Analysis of mRNA profiling data showed that both human and mouse metabolic dysfunction-associated steatotic liver disease (MASLD) were associated with reduced expression of ubiquitin-specific peptidase 25 (USP25) in hepatocytes.

Transcriptome Analysis of Liver Injury of Fatty Liver Disease Induced by ALDH2 Deficiency

January 20, 2025

[Scientific Reports] Researchers investigated the combined effects of aldehyde dehydrogenase 2 (ldh2) deficiency and high ethanol-producing Klebsiella pneumoniae on non-alcoholic fatty liver disease liver injury, transcriptome analyses to unearth potential mechanisms and therapeutic targets.

Iron Metabolism in a Mouse Model of Hepatocellular Carcinoma

January 20, 2025

[Scientific Reports] To investigate iron metabolism during liver carcinogenesis, researchers employed a model of chronic carbon tetrachloride injections in liver-specific p53-deficient mice to induce liver fibrosis, cirrhosis, and subsequent carcinogenesis.

Pellino 3 E3 Ligase Promotes Starvation-Induced Autophagy to Prevent Hepatic Steatosis

January 20, 2025

[Science Advances] Genetic deletion of pellino 3 in mice impaired fasting-induced autophagy in the liver and enhanced starvation-induced hepatic steatosis by reducing autophagy-mediated clearance of lipid droplets.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!