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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Liver Regeneration CRISPR Screen Identifies E3 Ligase NEURL1B Regulates Hepatocyte Mitosis by Destabilizing Microtubule Organizing Centers
[Gastroenterology] To understand how hepatocytes cope with mitotic challenges, the authors established a high-quality in vivo CRISPRi screen in regenerating mouse liver. By cross-referencing with gene essentiality data in cell lines, they identified genes required specifically by hepatocytes for proliferation.
CXCR4-Targeted Dual Softener for Inducing Senescence Therapy in Hepatic Fibrosis
[Proceedings of the National Academy of Sciences of the United States of America] Scientists developed an activated hepatic stellate cells (aHSCs)-targeted nanoplex that activates the stimulator of interferon genes pathway to induce senescence in aHSCs, while promoting endogenous immune surveillance-mediated clearance of aHSCs.
Hepatocellular Carcinoma Organoids Enable Drug Discovery and Combination Therapy across Heterogeneous Tumors
[Cell Reports] Researchers developed a patient-derived liver cancer organoid platform for high-throughput drug screening, identifying promising drug candidates and combination therapies across heterogeneous tumors.
K49 Acetylation of ACSL4 Antagonizes Its Ubiquitination Degradation and Promotes Tumorigenesis in Hepatocellular Carcinoma
[Cancer Letters] Investigators reported a previously unknown mechanism of acyl CoA synthetase 4 (ACSL4) regulation involving acetylation at the lysine 49 (K49) site by the acetyltransferase MOF.
PTEN-AKT2 Regulates Mixed Lineage Liver Cancer Development and Sensitizes Cancer Cells to TGFĪ² Treatment
[Oncogene] Using lineage-specific liver-targeted PTEN-deficient mouse models, we demonstrate that PTEN loss drives cellular dedifferentiation and tumorigenesis, a process that is critically dependent on AKT2.
AKR1B10 Drives Lenvatinib Resistance in Hepatocellular Carcinoma by Suppressing Ferroptosis via NQO1/GPX4 Axis
[Journal of Gastroenterology and Hepatology] Researchers investigated the interaction between ferroptosis and lenvatinib resistance in HCC and explores the underlying mechanisms.
Epigenetic Regulation in Liver Fibrosis: Focus on the Chromatin Accessibility Landscape
[European Journal of Pharmacology] Investigators highlight how dynamic chromatin accessibility regulates hepatic stellate cell activation and extracellular matrix deposition, revealing epigenetic targets for treating liver fibrosis.
NIH Awards $7.5 Million to Study Whether āForever Chemicalsā Increase the Risk of Liver and Endometrial Cancers
[Keck School of Medicine of USC] Researchers at the Keck School of Medicine of USC and USC Norris Comprehensive Cancer Center have received two grants from the National Institutes of Health (NIH) totaling $7.5 million to study whether exposure to per- and polyfluoroalkyl substances (PFAS) increases the risk of liver cancer and endometrial cancer.
Liver Organoids: From Disease Modeling to Regenerative Medicine
[Cell Proliferation] The authors systematically summarize current fabrication strategies, disease-modeling utilities and regenerative potentials of liver organoids, alongside the major challenges and future directions.
Scalable Synthetic Peptide Hydrogel Enables Self-Organized Luminal Cavity Architecture Within hiPSC 3D Colonies Supporting Functional Hepatocyte Differentiation
[Bioactive Materials] Scientists reported a scalable synthetic peptide hydrogel platform that enables hiPSCs to self-organize into long-term, proliferative luminal cavity architectures within 3D colonies.
Leveraging IGF Signaling to Improve the Spatial Organization and Regenerative Potential of iPSC-Derived Vascularized Liver Organoids
[Science Advances] Researchers developed vascularized liver organoids by integrating hiPSCāderived hepatoblasts and endothelial cells into decellularized scaffolds functionalized with an anti-CD31 aptamerābased vascular coating agent.
The Circadian Clock Controls Hepatic Stellate Cell Activation via a BMAL1/CK1Īµ/REV-ERBĪ±/Transgelin Signaling Pathway
[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that although the liver clock is generally maintained during human disease progression from a fatty liver to fibrosis, changes in circadian gene amplitude occur in people with obesity.
The publications featured inĀ Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
