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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
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Identification of a Common Ketohexokinase-Dependent Link Driving Alcohol Intake and Alcohol-Associated Liver Disease in Mice
[Nature Metabolism] The authors investigated whether alcohol preference and alcohol-associated liver disease are mediated through fructose metabolism by ketohexokinase-A/C.
Regenerating Liver Uses Ammonia to Support De Novo Pyrimidine Synthesis and Cell Proliferation
[Nature Communications] Scientists found that suppression of de novo pyrimidine synthesis prevents proliferation in regenerating liver, suppressing liver regrowth.
Inhibition of NLRP3 Inflammasome Activation Alleviated Liver Injury and Wasting Effect in Tumor-Bearing Mice
[Scientific Reports] RNA-seq data from the liver of Colon26 tumor-bearing mice were used to perform pathway enrichment analysis.
YTHDF1 Mediates KLF2/VSIG4 Axis to Regulate Kupffer Cell Polarization to Alleviate Sepsis-Induced Liver Injury
[Genes & Immunity] The effect of YTH domain N6-methyladenosine RNA binding protein F1 (YTHDF1) on Kupffer cell polarization in sepsis was evaluated.
METTL5 Promotes Fatty Acid Metabolism by Modulating Peroxisome to Promote Hepatocellular Carcinoma Recurrence after Thermal Ablation
[Molecular Therapy] Researchers found that the levels of methyltransferase 5 (METTL5) and 18S rRNA m6A modification were significantly upregulated in post-radiofrequency ablation (RFA) recurrent HCC and were further verified by insufficient RFA models in vitro and in vivo.
Targeting MORF4L1-Mediated DNA Repair Potentiates RT-Induced Antitumor Immunity via cGAS-STING Activation in Hepatocellular Carcinoma
[Cellular & Molecular Immunology] Single-cell and bulk RNA sequencing analyses identified the DNA damage repair gene mortality factor 4-like 1 (MORF4L1) as a critical regulator of hepatocellular carcinoma progression and resistance to radiotherapy.
Diclofenac and Acetaminophen Dim the Acute-Phase Response but Amplify Expression of the Iron Regulator Hepcidin in Liver Cancer Cells
[Cell Systems] Using proteomics and dynamic pathway modeling, investigators showed that diclofenac and acetaminophen directly impact IL-6 signaling by enhancing the induction of the feedback-inhibitor suppressor of cytokine signaling 3.
Hypoxia-Mediated m6a Modulation in Hepatocellular Carcinoma: A Comprehensive Review
[Journal of Translational Medicine] Investigators systematically elucidate the molecular mechanisms by which hypoxia-inducible factor and key m6A-modifying enzymes jointly regulate HCC progression within the hypoxic microenvironment.
Mursla Bio Collaborates with a Leading Global Pharma Company to Advance Biomarker-Guided Precision Medicine in MASH
[Mursla Bio] Mursla Bio announced a collaboration with a leading global pharmaceutical company recognized for its expertise in precision medicine and biomarker-guided drug development.
IL27RA Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma Cells by Regulating TGFβR1
[] Scientists revealed that IL27RA is significantly upregulated in HCC. Both in vitro and in vivo experiments demonstrated that IL27RA knockdown markedly inhibited the proliferation and metastasis of HCC cells.
MEF2D-Expressing Cancer Precursors Reprogram Tissue-Resident Macrophages to Support Liver Tumorigenesis
[Nature Cancer] The authors showed that elevated myocyte enhancer factor 2D (MEF2D)-expressing cancer precursors reprogram liver-resident macrophages, Kupffer cells, to create a growth-supportive environment.
Identification of an Effective Treatment for Liver Fibrosis Based on a Long Acting Easy to Deliver TNF-α-derived Peptide
[Pharmacological Research] The authors designed a tridomain Z-IgBD-P16, by sequentially fusing a platelet-derived growth factor receptor β (PDGFRβ)-specific affibody ZPDGFRβ and two repeats of IgG-binding domain (IgBD) to the N-terminus of P16.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
