Real-Time Lipid Patterns to Classify Viable and Necrotic Liver Tumors

The authors explored whether rapid evaporative ionization mass spectrometry lipid patterns ccould identify human liver tumors and improve the rapid characterization of their underlying metabolic features.
[Laboratory Investigation]
Vaysse, P.-M., Grabsch, H. I., van den Hout, M. F. C. M., Bemelmans, M. H. A., Heeren, R. M. A., Olde Damink, S. W. M., & Porta Siegel, T. (2021). Real-time lipid patterns to classify viable and necrotic liver tumors. Laboratory Investigation, 1–15. https://doi.org/10.1038/s41374-020-00526-w Cite
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Epithelium-Derived Indian Hedgehog Restricts Stromal Expression of ErbB Family Members That Drive Colonic Tumor Cell Proliferation

Scientists found that recombinant EREG, BTC, and NRG1 but not Lgr5 ligand R-Spondin promoted growth and proliferation of Apc double mutant colonic organoids.
[Oncogene]
Westendorp, F., Karpus, O. N., Koelink, P. J., Vermeulen, J. L. M., Meisner, S., Koster, J., Büller, N. V. J. A., Wildenberg, M. E., Muncan, V., & van den Brink, G. R. (2021). Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01633-0 Cite
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Inhibiting CBX4 Efficiently Protects Hepatocellular Carcinoma Cells against Sorafenib Resistance

Hepatocellular carcinom cell lines and a xenograft mouse model with resistance to sorafenib were employed to analyze the effects of miR424 on cancer stem cell characteristics.
[British Journal of Cancer]
Zhao, W., Ma, B., Tian, Z., Han, H., Tang, J., Dong, B., An, G., Cao, B., & Wang, B. (2021). Inhibiting CBX4 efficiently protects hepatocellular carcinoma cells against sorafenib resistance. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01240-6 Cite
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EMBO Installation Grants Support Eight Early-Career Scientists to Establish Independent Laboratories

EMBO has announced the award of Installation Grants to eight scientists in the early stages of setting up their independent laboratories in Lithuania, Poland, Portugal and Turkey.
[EMBO]
Press Release
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Targeting Transdifferentiated Hepatic Stellate Cells and Monitoring the Hepatic Fibrogenic Process by Means of IGF2R-Specific Peptides Designed In Silico

The structural information of the insulin-like growth factor 2 receptor (IGF2R), an overexpressed protein on activated hepatic stellate cells, were used for an in silico screening of novel IGF2R-specific peptide ligands.
[Journal of Materials Chemistry B]
Weber, F., Casalini, T., Valentino, G., Brülisauer, L., Andreas, N., Koeberle, A., Kamradt, T., Contini, A., & Luciani, P. (2021). Targeting transdifferentiated hepatic stellate cells and monitoring the hepatic fibrogenic process by means of IGF2R-specific peptides designed in silico. Journal of Materials Chemistry B. https://doi.org/10.1039/D0TB02372H Cite
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BNIP3-Dependent Mitophagy Promotes Cytosolic Localization of LC3B and Metabolic Homeostasis in the Liver

Investigators showed that BNIP3 is required for glucagon-induced mitophagy in the liver through interaction with processed LC3B; an interaction that is also necessary to localize LC3B out of the nucleus to cytosolic mitophagosomes in response to nutrient deprivation.
[Autophagy]
Springer, M. Z., Poole, L. P., Drake, L. E., Bock-Hughes, A., Boland, M. L., Smith, A. G., Hart, J., Chourasia, A. H., Liu, I., Bozek, G., & Macleod, K. F. (2021). BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2021.1877469 Cite
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Zonal Human Hepatocytes Are Differentially Permissive to Plasmodium falciparum Malaria Parasites

To understand specific host conditions that affect infectivity, the authors studied Plasmodium falciparum parasite liver stage development in relation to the metabolic heterogeneity of fresh human hepatocytes.
[EMBO Journal]
Yang, A. S. P., van Waardenburg, Y. M., van de Vegte-Bolmer, M., van Gemert, G.-J. A., Graumans, W., de Wilt, J. H. W., & Sauerwein, R. W. (2021). Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites. The EMBO Journal, n/a(n/a), e106583. https://doi.org/10.15252/embj.2020106583 Cite
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In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment

Scientists consider the benefits, limitations, and adaptations of specific in vitro approaches to assess DNA damage in the liver, whilst identifying critical advancements required to support a multitude of biochemical endpoints.
[Small]
Llewellyn, S. V., Niemeijer, M., Nymark, P., Moné, M. J., Water, B. van de, Conway, G. E., Jenkins, G. J. S., & Doak, S. H. (n.d.). In Vitro Three-Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, n/a(n/a), 2006055. https://doi.org/https://doi.org/10.1002/smll.202006055 Cite
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Inhibition of Histone Methyltransferase G9a Attenuates Liver Cancer Initiation by Sensitizing DNA-Damaged Hepatocytes to p53-Induced Apoptosis

Using liver-specific G9a-deficient mice, scientists revealed that loss of G9a significantly attenuated liver tumor initiation caused by diethylnitrosamine.
[Cell Death & Disease]
Nakatsuka, T., Tateishi, K., Kato, H., Fujiwara, H., Yamamoto, K., Kudo, Y., Nakagawa, H., Tanaka, Y., Ijichi, H., Ikenoue, T., Ishizawa, T., Hasegawa, K., Tachibana, M., Shinkai, Y., & Koike, K. (2021). Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis. Cell Death & Disease, 12(1), 1–13. https://doi.org/10.1038/s41419-020-03381-1 Cite
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IGFBPs Mediate IGF-1’s Functions in Retinal Lamination and Photoreceptor Development during Pluripotent Stem Cell Differentiation to Retinal Organoids

Researchers investigated the expression of insulin growth factor binding proteins and their role in the generation of human retinal organoids from human pluripotent stem cells.
[Stem Cells]
IGFBPs mediate IGF‐1’s functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids - Zerti - - STEM CELLS - Wiley Online Library. (n.d.). Retrieved January 15, 2021, from https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3331?af=R Cite
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Circular RNA circPSD3 Alleviates Hepatic Fibrogenesis by Regulating the miR-92b-3p/Smad7 Axis

In vitro loss-of-function and gain-of-function analyses suggested that circRNA derived from the Pleckstrin and Sec7 domain-containing 3 (circPSD3) inhibited the activation and proliferation of hepatic stellate cells.
[Molecular Therapy-Nucleic Acids]
Bu, F., Zhu, Y., Chen, X., Wang, A., Zhang, Y., You, H., Yang, Y., Yang, Y., Huang, C., & Li, J. (2021). Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.01.007 Cite
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