In an acetaminophen (APAP)-induced acute hepatic injury model, hepatocyte-specific miR-199a-3p knockout aggravated hepatic apoptosis.
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Scientists verified that Ether-à-go-go-1 (EAG1) promoted the proliferation of hepatocellular carcinoma both in vitro and in vivo. It promoted cell cycle progression by inhibiting the ubiquitination of SKP2.
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The authors summarize rapidly emerging clinical data on the promise and challenges of implementing immune checkpoint cascades in hepatocellular carcinoma and discuss the unmet need of biomarkers to predict response or resistance to therapy.
The aberrant glucose metabolism in cancer cells aerobic glycolysis is associated with resistance to chemotherapeutic agents. Drug-resistance cells and tumors were exposed to sorafenib to establish sorafenib-resistance cell lines and tumors.
[Cell Death & Disease]
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Inlighta Biosciences, LLC, a start-up company led by Jenny Yang, Regents’ Professor of Chemistry at Georgia State University, has been awarded a National Institute of Health grant to accelerate development of a magnetic resonance imaging contrast agent to detect liver fibrosis, formation of scar tissue in the liver caused by alcoholic and non-alcoholic fatty liver disease.
[Georgia State University]
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Functionally, zic family member 4 (ZIC4) inhibition facilitated the proliferation, migration, invasion, and epithelial-mesenchymal transition in vitro and in vivo. Conversely, ZIC4 overexpression reduced proliferation and invasiveness of hepatoceullar carcinoma cells.
[Cell Death & Disease]
In yes-associated protein (YAP)S127A-induced tumorigenesis, a gradual replacement of liver sinusoidal endothelial cells by continuous endothelial cells was associated with dynamic changes in the expression of genes involved in paracrine communication.
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Thomann, S., Weiler, S. M. E., Marquard, S., Rose, F., Ball, C. R., Tóth, M., Wei, T., Sticht, C., Fritzsche, S., Roessler, S., Torre, C. D. L., Ryschich, E., Ermakova, O., Mogler, C., Kazdal, D., Gretz, N., Glimm, H., Rempel, E., Schirmacher, P., & Breuhahn, K. (2020). YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0242 Cite
The authors summarize and discuss the current literature on nonalcoholic fatty liver disease (NAFLD) as the liver manifestation of the systemic metabolic syndrome and focuses on the role of peroxisome proliferator-activated receptors in the pathomechanisms as well as in the potential targeting of disease.
[Nature Reviews Gastroenterology & Hepatology]
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Francque, S., Szabo, G., Abdelmalek, M. F., Byrne, C. D., Cusi, K., Dufour, J.-F., Roden, M., Sacks, F., & Tacke, F. (2020). Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors. Nature Reviews Gastroenterology & Hepatology, 1–16. https://doi.org/10.1038/s41575-020-00366-5 Cite
In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
[Cell Death & Disease]
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Yang, W.-J., Sun, Y.-F., Jin, A.-L., Lv, L.-H., Zhu, J., Wang, B.-L., Zhou, Y., Zhang, C.-Y., Wang, H., Hu, B., Wang, P.-X., Te, L., Pan, B.-S., Zhou, J., Fan, J., Yang, X.-R., & Guo, W. (2020). BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity. Cell Death & Disease, 11(10), 1–13. https://doi.org/10.1038/s41419-020-03115-3 Cite
Scientists developed a defined, animal origin-free (CD-AOF) medium to generate all induced pluripotent stem cell-liver buds. Scientists developed a CD-AOF medium for hepatocytes, endothelial cells, and stage-matched mesenchymal stem cells i.e., septum transversum mesenchyme, in 2D cultures.
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Sekine, K., Ogawa, S., Tsuzuki, S., Kobayashi, T., Ikeda, K., Nakanishi, N., Takeuchi, K., Kanai, E., Otake, Y., Okamoto, S., Kobayashi, T., Takebe, T., & Taniguchi, H. (2020). Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media. Scientific Reports, 10(1), 17937. https://doi.org/10.1038/s41598-020-73908-1 Cite
Scientists showed that a set of three transcription factors, FOXA3, HNF1A, and HNF6, could induce human umbilical vein endothelial cells to directly acquire the properties of human hepatic progenitor cells.
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Inada, H., Udono, M., Matsuda-Ito, K., Horisawa, K., Ohkawa, Y., Miura, S., Goya, T., Yamamoto, J., Nagasaki, M., Ueno, K., Saitou, D., Suyama, M., Maehara, Y., Kumamaru, W., Ogawa, Y., Sekiya, S., & Suzuki, A. (2020). Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells. Nature Communications, 11(1), 5292. https://doi.org/10.1038/s41467-020-19041-z Cite