Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Angiopoietin-2 Inhibition Attenuates Kidney Fibrosis by Hindering Chemokine C-C Motif Ligand 2 Expression and Apoptosis of Endothelial Cells.

[Kidney International] Researchers found in a cohort of 319 patients with chronic kidney disease that plasma angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratios were positively associated with the development of kidney failure.

MiR-182-5p Promotes Hepatocyte-Stellate Cell Crosstalk to Facilitate Liver Regeneration

[Communications Biology] Overexpression of miR-182-5p failed to promote proliferation in hepatocytes, but stimulated proliferation when hepatocytes were cocultured with stellate cells.

A Maternal High-Fat Diet Induces Fetal Origins of NASH-HCC in Mice

[Scientific Reports] Scientists showed that male offspring from high-fat diet-fed dams developed a severe form of nonalcoholic steatohepatitis (NASH), leading to highly vascular tumor formation.

Comparative Analysis of Bilirubin Glucuronidation Activity in Canine and Human Primary Hepatocytes Using a 3D Culture System

[In Vitro Cellular & Developmental Biology - Animal] Bilirubin glucuronidation activity was examined in canine and human primary hepatocyte spheroids formed using a 3D culture system.

CFI-402257, a TTK Inhibitor, Effectively Suppresses Hepatocellular Carcinoma

[Proceedings of the National Academy of Sciences of the United States of America] Investigators reported that a newly developed, orally active small molecule inhibitor targeting threonine tyrosine kinase (TTK) effectively suppressed HCC growth and induced highly aneuploid HCC cells, DNA damage, and micronuclei formation.

S100a16 Deficiency Prevents Hepatic Stellate Cells Activation and Liver Fibrosis via Inhibiting CXCR4 Expression

[Metabolism Clinical and Experimental] Hepatic stellate cells (HSCs) were isolated, and the relationship between S100A16 expression and HSCs activation was studied.

Liver Dysfunction and Energy Storage Mobilization in Traíra, Hoplias malabaricus (Teleostei, Erythrinidae) Induced by Subchronic Exposure to Toxic Cyanobacterial Crude Extract

[Environmental Toxicology] Researchers investigated the liver and hepatocyte structures and the activity of key hepatic functional enzymes with emphasis on energetic metabolism changes after subchronic fish exposure to cyanobacterial crude extract containing microcystins.

Aberrant Iron Distribution via Hepatocyte-Stellate Cell Axis Drives Liver Lipogenesis and Fibrosis

[Cell Metabolism] Scientists showed that non-alcoholic fatty liver disease and steatohepatitis were characterized by iron-deficient hepatocytes and iron overload in hepatic stellate cells.

NXN Suppresses Metastasis of Hepatocellular Carcinoma by Promoting Degradation of Snail through Binding to DUB3

[Cell Death & Disease] The role of nucleoredoxin on HCC proliferation was determined by CCK-8, EdU and colony formation assays in vitro and subcutaneous tumor formation model in vivo.

Inhibition of Polyploidization in Pten-Deficient Livers Reduces Steatosis

[Liver International] Scientists used a liver-specific conditional knockout approach to delete Pten in combination with deletion of E2f7/8, known key inducers of polyploidization.

Long Noncoding RNA CERS6-AS1 Modulates Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma by Promoting the MDM2/p53 Signaling Pathway

[Cell Death Discovery] Scientists investigated the underlying mechanism of the long non-coding RNA CERS6-AS1 in HCC progression.

The m6A Methyltransferase Mettl3 Deficiency Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis

[Molecular Therapy] The authors found that the hepatic stellate cell (HSC)-specific knockout of m6A methyltransferase Mettl3 suppressed HSC activation and significantly alleviated liver fibrosis.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!