SMYD3 Promotes Hepatocellular Carcinoma Progression by Methylating S1PR1 Promoters

Researchers reported that SET and MYND domain-containing protein 3 (SMYD3) expression in hepatocellular carcinoma (HCC) was an independent prognostic factor for survival and promoted the proliferation and migration of HCC cells.
[Cell Death & Disease]
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Eureka Therapeutics Announces Initiation of Phase I/II ARYA-3 Clinical Trial of GPC3 Targeting ARTEMIS® T Cell Therapy in Liver Cancer

Eureka Therapeutics, Inc. announced the initiation of a Phase I/II clinical trial of ECT204, a GPC3 targeting ARTEMIS® T-cell therapy for the treatment of hepatocellular carcinoma, the predominant type of liver cancer.
[Eureka Therapeutics, Inc.]
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Use of Human Tissue Stem Cell-Derived Organoid Cultures to Model Enterohepatic Circulation

Researchers demonstrated that mature stem cell-derived intestinal and liver organoid cultures each express functional molecules that modulate bile acid uptake and recycling.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Blutt, S. E., Crawford, S., Bomidi, C., Zeng, X.-L., Broughman, J., Robertson, M., Coarfa, C., Tessier, M. E., Savidge, T. C., Hollinger, F. B., Curley, S., Donowitz, M., & Estes, M. K. (2021). Use of Human Tissue Stem Cell-Derived Organoid Cultures to Model Enterohepatic Circulation. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00177.2021 Cite
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CD8+ Tissue-Resident Memory T Cells Promote Liver Fibrosis Resolution by Inducing Apoptosis of Hepatic Stellate Cells

Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.
[Nature Communications]
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Circular Noncoding RNA hsa_circ_0005986 as a Prognostic Biomarker for Hepatocellular Carcinoma

Scientists evaluated the expression of a recently identified circRNA, hsa_circ_0005986; determineD its clinical significance; and evaluateD its potential as a biomarker of hepatocellular carcinoma.
[Scientific Reports]
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Modeling Alcohol-Associated Liver Disease in a Human Liver-Chip

Investigators leveraged a triculture human Liver-Chip with biomimetic hepatic sinusoids and bile canaliculi to model ALD employing human-relevant blood alcohol concentrations and multimodal profiling of clinically relevant endpoints.
[Cell Reports]
Nawroth, J. C., Petropolis, D. B., Manatakis, D. V., Maulana, T. I., Burchett, G., Schlünder, K., Witt, A., Shukla, A., Kodella, K., Ronxhi, J., Kulkarni, G., Hamilton, G., Seki, E., Lu, S., & Karalis, K. C. (2021). Modeling alcohol-associated liver disease in a human Liver-Chip. Cell Reports, 36(3). https://doi.org/10.1016/j.celrep.2021.109393 Cite
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Dynamin-Related Protein 1 Deficiency Accelerates Lipopolysaccharide-Induced Acute Liver Injury and Inflammation in Mice

Researchers hypothesized that dynamin-related protein 1 defects were a causal factor directly involved in liver disease development and stimulated liver disease progression.
[Communications Biology]
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PPM1G Promotes the Progression of Hepatocellular Carcinoma via Phosphorylation Regulation of Alternative Splicing Protein SRSF3

Scientists showed that the PPM1G, a protein phosphatase, regulated the phosphorylation of SRSF3 in hepatocellular carcinoma (HCC) and contributed to the proliferation, invasion, and metastasis of HCC.
[Cell Death & Disease]
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EGFR Activation Limits the Response of Liver Cancer to Lenvatinib

The combination of the epidermal growth factor receptor (EGFR) inhibitor gefitinib and lenvatinib displayed potent anti-proliferative effects in vitro in liver cancer cell lines that expressed EGFR.
[Nature]
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The Aetiology and Molecular Landscape of Insulin Resistance

Scientists hypothesized that deregulation in the maintenance of the pool of coenzyme A might play a crucial role in the pathogenesis of nonalcoholic fatty liver disease.
[Experimental and Molecular Medicine]
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Bromodomain-Containing Protein BRPF1 Is a Therapeutic Target for Liver Cancer

Gene ablation or pharmacological inactivation of BRPF1 (bromodomain and PHD finger containing 1) significantly attenuated hepatocellular carcinoma cell growth in vitro and in vivo.
[Communications Biology]
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