Advances in Immunotherapy for Hepatocellular Carcinoma

The authors provide up-to-date information on the best use of currently available immunotherapies in hepatocellular carcinoma and the therapeutic strategies under development.
[Nature Reviews Gastroenterology & Hepatology]
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Bmal1 Inhibits Phenotypic Transformation of Hepatic Stellate Cells in Liver Fibrosis via IDH1/α-KG-Mediated Glycolysis

Scientists showed that glycolysis was significantly enhanced, while the expression of brain and muscle arnt-like protein-1 (Bmal1) was downregulated in fibrotic liver tissues of mice, primary Hepatic stellate cells (HSCs), and transforming growth factor-β1 (TGF-β1)-induced LX2 cells.
[Acta Pharmaceutica Sinica B]
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TriSalus Life Sciences and MD Anderson Announce Strategic Research Collaboration to Evaluate Treatment of Solid Tumors

The University of Texas MD Anderson Cancer Center and TriSalus Life Sciences®, announced a strategic research collaboration to evaluate the treatment of tumors of the pancreas and liver by integrating interventional delivery of SD-101, an investigational toll-like receptor 9 agonist, in combination with checkpoint inhibition immunotherapy.
[TriSalus Life Sciences]
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Synergistic Effect of the TLR5 Agonist CBLB502 and Its Downstream Effector IL-22 against Liver Injury

Scientists investigated the protective mechanism of CBLB502 in the liver using models of ischemia-reperfusion injury and concanavalin A induced immuno-hepatitis.
[Cell Death & Disease]
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The Pah-R261Q Mouse Reveals Oxidative Stress Associated with Amyloid-Like Hepatic Aggregation of Mutant Phenylalanine Hydroxylase

Researchers showed that Pah-R261Q hepatic tissue exhibited large ubiquitin-positive, amyloid-like oligomeric aggregates of mutant phenylalanine hydroxylase that colocalized with selective autophagy markers.
[Nature Communications]
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Mechanical Homeostasis of Liver Sinusoid Is Involved in the Initiation and Termination of Liver Regeneration

Researchers found that mechanical homeostasis, which is crucial for organ morphogenesis and functioned in various phenomena, played essential roles in liver regeneration for both initiation and termination of liver regeneration, which is regulated by cytokine networks.
[Communications Biology]
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A Selective HDAC8 Inhibitor Potentiates Antitumor Immunity and Efficacy of Immune Checkpoint Blockade in Hepatocellular Carcinoma

The authors demonstrated that selective HDAC8 inhibition elicited effective and durable responses to immune-checkpoint blockade by co-opting adaptive immunity through enhancer reprogramming.
[Science Translational Medicine]
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Loss-of-Function Genetic Screening Identifies ALDOA as an Essential Driver for Liver Cancer Cell Growth under Hypoxia

Scientists identified aldolase A (ALDOA), a key enzyme in glycolysis and gluconeogenesis, as an essential driver for HCC cell growth under hypoxia.
[Hepatology]
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CD47-Mediated Hedgehog/SMO/GLI1 Signaling Promotes Mesenchymal Stem Cell Immunomodulation in Mouse Liver Inflammation

Investigators found that mesenchymal stem cell CD47 and macrophage signal regulatory protein alpha expression were increased after LPS stimulation.
[Hepatology]
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Biological Nanotherapeutics for Liver Disease

Researchers discuss the cellular sources of EV, provide a concise overview of their potential use in diverse processes, and outline several promising applications for the use of EV based therapeutics for liver diseases.
[Hepatology]
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Global Changes to HepG2 Cell Metabolism in Response to Galactose Treatment

Scientists performed transcriptomic and metabolomic analyses on human hepatocellular carcinoma cells adapted to either glucose or galactose as the aldohexose source.
[American Journal of Physiology-Cell Physiology]
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