Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
The P-MYH9/USP22/HIF-1α Axis Promotes Lenvatinib Resistance and Cancer Stemness in Hepatocellular Carcinoma
[Signal Transduction and Targeted Therapy] Scientists dissected the underlying mechanism of lenvatinib resistance (LR) and provide effective treatment strategies. They established an HCC model of acquired LR. Cell counting, migration, self-renewal ability, chemoresistance and expression of stemness genes were used to detect the stemness of HCC cells.
Berberine Potentiates Liver Inflammation and Fibrosis in the PI*Z hAAT Transgenic Murine Model
[PLOS One] Investigators explored the therapeutic effects and toxicities of berberine in Pi*Z hepatocytes and Pi*Z transgenic mice.
A FAPα-Activated MRI Nanoprobe for Precise Grading Diagnosis of Clinical Liver Fibrosis
[Nature Communications] Scientists discovered the grading potential of fibroblast activation protein alpha for liver fibrosis through transcriptional analysis and biological assays on clinical liver samples.
Advances in the Understanding of the Role and Mechanism of Action of PFKFB3-Mediated Glycolysis in Liver Fibrosis (Review)
[International Journal of Molecular Medicine] The authors review the research progress on the role and mechanism of action of 6‑phosphofructo‑2‑kinase/fructose‑2,6‑bisphosphatase 3 (PFKFB3)‑mediated glycolysis in the progression of hepatic fibrosis to discuss the role of PFKFB3‑mediated glycolysis in hepatic fibrosis.
Obesity-Drug Pioneers Win Prestigious Lasker Award for Medical Science
[Nature] Three scientists involved in developing the blockbuster anti-obesity drugs that are currently changing the health-care landscape are among the winners of this year’s prestigious Lasker Awards.
Gaudichaudione H Ameliorates Liver Fibrosis and Inflammation by Targeting NRF2 Signaling Pathway
[Free Radical Biology and Medicine] Researchers underscored the potential therapeutic effect of Gaudichaudione H on alleviating hepatic fibrosis and inflammation through the augmentation of NRF2 signaling pathway, providing a promising avenue for the treatment of liver fibrosis and inflammation in clinical settings.
EGCG Suppressed Activation of Hepatic Stellate Cells by Regulating the PLCE1/IP3/Ca2+ Pathway
[European Journal of Nutrition] Investigators suggested that oral administration of (-)-Epigallocatechin-3-O-gallate (EGCG) at a dosage of 200 mg/kg/day for a duration of four weeks exhibits significant therapeutic potential in a murine model of liver fibrosis induced by CCl4.
A Monoclonal Antibody Recognizing CD98 on Human Embryonic Stem Cells Shows Anti-tumor Activity in Hepatocellular Carcinoma Xenografts
[Cancer Immunology Immunotherapy] Researchers generated a panel of monoclonal antibodies against surface proteins on human embryonic stem cells.
HIF-2α Drives Hepatic Kupffer Cell Death and Proinflammatory Recruited Macrophage Activation in Nonalcoholic Steatohepatitis
[Science Translational Medicine] Researchers showed that hypoxia-inducible factor 2α (HIF-2α) mediated nonalcoholic steatohepatitis-associated decreased Kupffer cell growth and efferocytosis by enhancing lysosomal stress.
Wedelolactone Attenuates Liver Fibrosis and Hepatic Stellate Cell Activation by Suppressing the Hippo Pathway
[Rejuvenation Research] Researchers found that wedelolactone (WED) significantly alleviated liver fibrosis and injury by inhibiting the expression of YAP and TAZ. In an in vitro model, WED suppressed the activation of hepatic stellate cells induced by TGF-β1 and the mRNA and protein expression of α-SMA, YAP, and TAZ.
Adipocyte Inflammation Is the Primary Driver of Hepatic Insulin Resistance in a Human iPSC-Based Microphysiological System
[Nature Communications] To address the need for an accurate in vitro model, researchers established an interconnected microphysiological system containing white adipocytes, hepatocytes, and proinflammatory macrophages derived from isogenic human induced pluripotent stem cells.
Epitranscriptomic Regulation of Lipid Oxidation and Liver Fibrosis via ENPP1 mRNA m6A Modification
[Cellular and Molecular Life Sciences] Scientists investigated the causes and consequences of lipid oxidation in liver fibrosis using cultured cells, animal models, and clinical samples.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
