Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Phenotypes of MASLD-Associated Hepatocellular Carcinoma

[Clinical Gastroenterology And Hepatology] Metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis, has emerged as the most common chronic liver disease worldwide and a leading cause of HCC.

Blue Faery Awards Liver Cancer Research Grant

[Blue Faery (PR Newswire, Inc.)] Blue Faery: The Adrienne Wilson Liver Cancer Association announced the annual Blue Faery Award (BFA) for Excellence in Liver Cancer Research. Primary liver cancer, also known as HCC, is the third leading cause of cancer deaths worldwide. Blue Faery created the award to recognize medical professionals who do innovative HCC research.

‘Mini Liver’ Will Grow in Person’s Own Lymph Node in Bold New Trial

[Nature] A person has received an experimental treatment for the first time that, if successful, will lead them to grow an additional ‘miniature liver’. The procedure, developed by the biotechnology firm LyGenesis, marks the beginning of a clinical trial designed for people whose livers are failing, but who have not received an organ transplant.

Diagnostic Performance of PIVKA-II in Identifying Recurrent Hepatocellular Carcinoma following Curative Resection: A Retrospective Cohort Study

[Scientific Reports] A multicenter, retrospective, and observational study was conducted. During the overall follow-up of five years, HCC patients who had curative resection were monitored every three months in the first year post-surgery and every six months thereafter if no recurrence occurred.

cGAS Suppresses Hepatocellular Carcinoma Independent of Its cGAMP Synthase Activity

[Cell Death & Differentiation] The authors revealed that Cyclic GMP–AMP synthase (cGAS) was significantly downregulated in clinical HCC tissues, and its dysregulation contributed to the progression of HCC.

Eureka Therapeutics Announces UCSF Benioff Children’s Hospitals as First California Site for ARYA-2 Clinical Trial Targeting Pediatric Liver Cancers

[Eureka Therapeutics, Inc.] Eureka Therapeutics, Inc., a clinical-stage biotechnology company developing novel T cell therapies to treat cancer, announced the activation of UCSF Benioff Children’s Hospitals as the first California site to join the ARYA-2 clinical trial.

Hepatocyte Regeneration Is Driven by Embryo-Like DNA Methylation Reprogramming

[Proceedings Of The National Academy Of Sciences Of The United States Of America] By following the early stages of this process, investigators observed dramatic programmed changes in the DNA methylation profile, characterized by both de novo and demethylation events, with a subsequent return to the original adult pattern as the liver matures.

Proteomic Analysis of DEN and CCl4-Induced Hepatocellular Carcinoma Mouse Model

[Scientific Reports] Scientists performed proteomic analysis of this model to elucidate its proteomic characteristics. Compared with normal liver tissues, 432 differentially expressed proteins were identified in tumor tissues, among which 365 were up-regulated and 67 were down-regulated.

17β-Estradiol Protects Female Rats from Bilateral Oophorectomy-Induced Nonalcoholic Fatty Liver Disease Induced by Improving Linoleic Acid Metabolism Alteration and Gut Microbiota Disturbance

[Heliyon] The combination of liver transcriptomics and metabolomics analysis revealed that linoleic acid (LA) metabolism, a pivotal pathway in fatty acids metabolism was mainly manipulated during the induction and treatment of nonalcoholic fatty liver disease.

Single-Cell Multiomics Reveals the Interplay of Clonal Evolution and Cellular Plasticity in Hepatoblastoma

[Nature Communications] Scientists used a single-cell multiomic strategy to unravel the molecular determinants of this plasticity. They identified a continuum of hepatoblastoma cell states between hepatocytic, liver progenitor, and mesenchymal differentiation poles, with an intermediate scH/LP population bordering scLP and scH areas in spatial transcriptomics.

TDF and TAF Inhibit Liver Cancer Cell Migration, Invasion via p7TP3

[Scientific Reports] Researchers investigated the the roles and mechanisms of tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), and entecavir on the malignant characteristics of liver cancer cells.

Histone Methyltransferase Suv39h1 Regulates Hepatic Stellate Cell Activation and Is Targetable in Liver Fibrosis

[Gut] The authors investigated the role of Suv39h1, a lysine methyltransferase, in HSC-myofibroblast transition and the implication in liver fibrosis. HSC-specific or myofibroblast-specifiSuv39h1 deletion was achieved by crossbreeding the Suv39h1 f/f mice to the Lrat-Cre mice or the Postn-CreERT2 mice.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!