Category Archives: Hepatic Cell

Hepatic Cell News is an online publication and email newsletter covering the top research on hepatocytes and liver diseases.
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The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. The newsletter covers areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

microRNA-199a-3p Inhibits Hepatic Apoptosis and Hepatocarcinogenesis by Targeting PDCD4

In an acetaminophen (APAP)-induced acute hepatic injury model, hepatocyte-specific miR-199a-3p knockout aggravated hepatic apoptosis.
[Oncogenesis]
Li, Z., Zhou, Y., Zhang, L., Jia, K., Wang, S., Wang, M., Li, N., Yu, Y., Cao, X., & Hou, J. (2020). microRNA-199a-3p inhibits hepatic apoptosis and hepatocarcinogenesis by targeting PDCD4. Oncogenesis, 9(10), 1–14. https://doi.org/10.1038/s41389-020-00282-y Cite
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EAG1 Enhances Hepatocellular Carcinoma Proliferation by Modulating SKP2 and Metastasis through Pseudopod Formation

Scientists verified that Ether-à-go-go-1 (EAG1) promoted the proliferation of hepatocellular carcinoma both in vitro and in vivo. It promoted cell cycle progression by inhibiting the ubiquitination of SKP2.
[Oncogene]
Chen, J., Xuan, Z., Song, W., Han, W., Chen, H., Du, Y., Xie, H., Zhao, Y., Zheng, S., & Song, P. (2020). EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01522-6 Cite
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The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma

The authors summarize rapidly emerging clinical data on the promise and challenges of implementing immune checkpoint cascades in hepatocellular carcinoma and discuss the unmet need of biomarkers to predict response or resistance to therapy.
[JAMA Oncology]
Pinter, M., Jain, R. K., & Duda, D. G. (2020). The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review. JAMA Oncology. https://doi.org/10.1001/jamaoncol.2020.3381 Cite
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The miR-30a-5p/CLCF1 Axis Regulates Sorafenib Resistance and Aerobic Glycolysis in Hepatocellular Carcinoma

The aberrant glucose metabolism in cancer cells aerobic glycolysis is associated with resistance to chemotherapeutic agents. Drug-resistance cells and tumors were exposed to sorafenib to establish sorafenib-resistance cell lines and tumors.
[Cell Death & Disease]
Zhang, Z., Tan, X., Luo, J., Yao, H., Si, Z., & Tong, J.-S. (2020). The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03123-3 Cite
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Georgia State Start-Up Awarded NIH Grant To Develop Contrast Agent for Early Detection of Liver Disease

Inlighta Biosciences, LLC, a start-up company led by Jenny Yang, Regents’ Professor of Chemistry at Georgia State University, has been awarded a National Institute of Health grant to accelerate development of a magnetic resonance imaging contrast agent to detect liver fibrosis, formation of scar tissue in the liver caused by alcoholic and non-alcoholic fatty liver disease.
[Georgia State University]
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Epigenetic Silencing of ZIC4 Contributes to Cancer Progression in Hepatocellular Carcinoma

Functionally, zic family member 4 (ZIC4) inhibition facilitated the proliferation, migration, invasion, and epithelial-mesenchymal transition in vitro and in vivo. Conversely, ZIC4 overexpression reduced proliferation and invasiveness of hepatoceullar carcinoma cells.
[Cell Death & Disease]
Chen, W., Tang, D., Tang, D., & Dai, Y. (2020). Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma. Cell Death & Disease, 11(10), 1–11. https://doi.org/10.1038/s41419-020-03109-1 Cite
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YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/C-MET Signaling in Liver Tumorigenesis

In yes-associated protein (YAP)S127A-induced tumorigenesis, a gradual replacement of liver sinusoidal endothelial cells by continuous endothelial cells was associated with dynamic changes in the expression of genes involved in paracrine communication.
[Cancer Research]
Thomann, S., Weiler, S. M. E., Marquard, S., Rose, F., Ball, C. R., Tóth, M., Wei, T., Sticht, C., Fritzsche, S., Roessler, S., Torre, C. D. L., Ryschich, E., Ermakova, O., Mogler, C., Kazdal, D., Gretz, N., Glimm, H., Rempel, E., Schirmacher, P., & Breuhahn, K. (2020). YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0242 Cite
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Nonalcoholic Steatohepatitis: The Role of Peroxisome Proliferator-Activated Receptors

The authors summarize and discuss the current literature on nonalcoholic fatty liver disease (NAFLD) as the liver manifestation of the systemic metabolic syndrome and focuses on the role of peroxisome proliferator-activated receptors in the pathomechanisms as well as in the potential targeting of disease.
[Nature Reviews Gastroenterology & Hepatology]
Francque, S., Szabo, G., Abdelmalek, M. F., Byrne, C. D., Cusi, K., Dufour, J.-F., Roden, M., Sacks, F., & Tacke, F. (2020). Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors. Nature Reviews Gastroenterology & Hepatology, 1–16. https://doi.org/10.1038/s41575-020-00366-5 Cite
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BCL11B Suppresses Tumor Progression and Stem Cell Traits in Hepatocellular Carcinoma by Restoring p53 Signaling Activity

In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
[Cell Death & Disease]
Yang, W.-J., Sun, Y.-F., Jin, A.-L., Lv, L.-H., Zhu, J., Wang, B.-L., Zhou, Y., Zhang, C.-Y., Wang, H., Hu, B., Wang, P.-X., Te, L., Pan, B.-S., Zhou, J., Fan, J., Yang, X.-R., & Guo, W. (2020). BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity. Cell Death & Disease, 11(10), 1–13. https://doi.org/10.1038/s41419-020-03115-3 Cite
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Generation of Human Induced Pluripotent Stem Cell-Derived Liver Buds with Chemically Defined and Animal Origin-Free Media

Scientists developed a defined, animal origin-free (CD-AOF) medium to generate all induced pluripotent stem cell-liver buds. Scientists developed a CD-AOF medium for hepatocytes, endothelial cells, and stage-matched mesenchymal stem cells i.e., septum transversum mesenchyme, in 2D cultures.
[Scientific Reports]
Sekine, K., Ogawa, S., Tsuzuki, S., Kobayashi, T., Ikeda, K., Nakanishi, N., Takeuchi, K., Kanai, E., Otake, Y., Okamoto, S., Kobayashi, T., Takebe, T., & Taniguchi, H. (2020). Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media. Scientific Reports, 10(1), 17937. https://doi.org/10.1038/s41598-020-73908-1 Cite
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Direct Reprogramming of Human Umbilical Vein- and Peripheral Blood-Derived Endothelial Cells into Hepatic Progenitor Cells

Scientists showed that a set of three transcription factors, FOXA3, HNF1A, and HNF6, could induce human umbilical vein endothelial cells to directly acquire the properties of human hepatic progenitor cells.
[Nature Communications]
Inada, H., Udono, M., Matsuda-Ito, K., Horisawa, K., Ohkawa, Y., Miura, S., Goya, T., Yamamoto, J., Nagasaki, M., Ueno, K., Saitou, D., Suyama, M., Maehara, Y., Kumamaru, W., Ogawa, Y., Sekiya, S., & Suzuki, A. (2020). Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells. Nature Communications, 11(1), 5292. https://doi.org/10.1038/s41467-020-19041-z Cite
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