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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
UCLA Researchers Awarded $3.2 Million NIH Grant to Develop AI Tool for More Personalized Liver Cancer Treatment
[UCLA Health] UCLA researchers Drs. Jason Chiang and Kyung Sung were awarded a $3.2 million NCI grant to develop AI-driven imaging technology for improved Y90 treatment planning in liver cancer.
Multimodal Sequencing Identifies Synergistic Mechanisms Driving Resistance to Neoadjuvant Nivolumab Treatment in Hepatocellular Carcinoma
[Molecular Cancer] Scientists identified a complex network of immune suppression and lipid metabolic reprogramming that contributes to immunotherapy resistance in liver cancer.
Integrative Analyses Elucidate Transcriptional Regulatory Functions of Risk Alleles for Metabolic Liver Disease
[Nature Genetics] Researchers mapped chromatin accessibility in human MASLD liver nuclei, revealing enrichment of risk variants within cell-type-specific regulatory elements bound by lineage-determining transcription factors.
Fructose 1-Phosphate Inhibits Mannose Phosphate Isomerase to Suppress Hepatocellular Carcinogenesis
[Signal Transduction and Targeted Therapy] Investigators reported that fructose suppresses HCC through fructose 1-phosphate-mediated inhibition of mannose phosphate isomerase in the context of fructose-1,6-bisphosphate aldolase B deficiency.
Claudin-1 Targeting Suppresses Tumor Growth, Invasion, and Metastasis in Patient-Derived Cholangiocarcinoma Models
[Science Translational Medicine] Using single-cell RNA sequencing and spatial transcriptomics of tissues of patients with CCA, researchers showed that CLDN1 expression is up-regulated in cancer cells and is associated with stemness and cell fate.
Hyperactivated Glycolysis Drives Spatially Patterned Kupffer Cell Depletion in MASLD
[Elife] Scientists sought to elucidate the metabolic basis of Kupffer cell (KC) death during metabolic dysfunction-associated steatotic liver disease (MASLD). Using metabolomics, immunostaining, and flow cytometry, they evaluated metabolic alterations and KC death throughout early MASLD progression.
Activation of Methionine Metabolism Mediated by HNF4Ī± Confers Ferroptosis Resistance in Hepatocellular Carcinoma
[Cell Death Discovery] The authors explored the mechanisms of epithelial HCC cells (EC) acquire resistance to ferroptosis. Transcriptomics and metabolomics analyses revealed that the cysteine and methionine metabolic pathway is associated with the resistance of EC to ferroptosis inducer imidazole ketone erastin.
m6a Modification-Mediated lncRNA UNC5B-AS1 Enhances HCC Progression through miR-760/IL6 Axis
[Scientific Reports] Researchers found that the m6A modification sites are highly abundant on UNC5B-AS1, and methylase WT1-associated protein enhances UNC5B-AS1 stability through m6A reader-YTHDF1 and up-regulates its expression in HCC.
Hepatic Lipoprotein Production, Cardiometabolic Phenotypes, and Subtypes of Steatotic Liver Disease
[Circulation Research] Scientists explore a deeper understanding of hepatic lipid and lipoprotein homeostasis in MASLD for several reasons connected with some of the molecular and signaling adaptations occurring in obesity and type 2 diabetes.
Neutrophil Extracellular Traps: A Central Player in Liver Diseases
[Hepatology Communications] The authors discuss recent findings related to neutrophil extracellular traps in inflammatory and fibrotic liver diseases as well as liver cancer.
Glycine: The Missing Link between Carbohydrate and Xenobiotic Metabolism in the Maturing Human Hepatocyte
[iScience] Researchers examined the remodeling of central and xenobiotic metabolism during the glycine-supplemented differentiation of iPSCs into hepatocyte-like cells and HepG2 into a metabolically active form.
ISG15 Deficiency in Hepatic Stellate Cells Promotes TGFĪ²2-Induced Liver Fibrosis by Counteracting CREB1 ISGylation
[Gut] Researchers examined the role of interferon-stimulated gene 15 (ISG15) in the activation of hepatic stellate cells and liver fibrosis.
The publications featured inĀ Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
