Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

An Unconventional Cancer-Promoting Function of Methamphetamine in Hepatocellular Carcinoma

[Life Science Alliance] Scientists found a higher HCC incidence in methamphetamine (METH) abusers. METH promoted cellular proliferation, migration, and invasion in two human-derived HCC cells.

Hepatic TNFRSF12A Promotes Bile Acid-Induced Hepatocyte Pyroptosis through NFκB/Caspase-1/GSDMD Signaling in Cholestasis

[Cell Death Discovery] Human hepatoma PLC/PRF/5-ASBT and THP1 cell lines or primary mouse hepatocytes were used for mechanistic studies. Hepatic TNFRSF12A expression was markedly increased in obstructive cholestasis or primary biliary cholangitis patients.

YAP1 Suppression Inhibits Autophagy and Improves the Efficacy of Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma

[Experimental Cell Research] YAP1 expression and autophagy constituted positive feedback, in which YAP1 inhibition decreased the autophagy activity in liver tumor cells by hepatocyte-specific Yap1 knockout mice.

EGFR and Lyn Inhibition Augments Regorafenib Induced Cell Death in Sorafenib Resistant 3D Tumor Spheroid Model

[Cellular Signalling] Investigators utilized sorafenib resistant Huh7 cell line and LX2 hepatic stellate cell line to establish a sorafenib resistant 3D tumor spheroid model which could be used to test second-line treatment options.

Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma Progression

[Oncology Reports] Scientists discuss the relationship of protein tyrosine phosphatases (PTPs) with inflammatory cytokines and chemotherapy/targeted drug resistance, providing detailed information on how PTPs can modulate inflammatory reactions and drug resistance to influence progression in HCC.

The Transcription Factor ATF3 Switches Cell Death from Apoptosis to Necroptosis in Hepatic Steatosis in Male Mice

[Nature Communications] The authors show that hepatic steatosis aggravation shifts the hepatocellular death mode from apoptosis to necroptosis, causing increased hepatocellular death.

Tuning the Corona-Core Ratio of Polyplex Micelles for Selective Oligonucleotide Delivery to Hepatocytes or Hepatic Immune Cells

[Biomaterials] Applying Raman-spectroscopy and dynamic in silico modeling on the polyplex micelles, researchers determined the corona-core ratio (CCR) and visualized the possible micellar structure with varying CCR.

NFYAv1 is a Tumor-Promoting Transcript Associated with Poor Prognosis of Hepatocellular Carcinoma

[Medical Science Monitor] RNA-seq data from the Genotype-Tissue Expression Project and TCGA were analyzed in combination. In vitro cellular and molecular studies were conducted using SK-Hep-1 and Hep3B cells.

Experimental and Computational Studies of Silver(I) Dibenzoylmethane-Based Complexes, Interaction with DNA/RNA/BSA Biomolecules, and In Vitro Cytotoxic Activity

[Journal Of Inorganic Biochemistry] Ag(I) ion was found to be coordinated with the ligand's oxygens in almost a linear fashion in complex, while in complex it adopted a tetrahedral geometry.

Damon Runyon Cancer Research Foundation Awards over $4.3M to Top Young Scientists

[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has announced its newest class of Damon Runyon Fellows, 14 exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

Murine Breast Cancers Disorganize the Liver Transcriptome in a Zonated Manner

[Communications Biology] Using spatial transcriptomics, the authors investigated the abundance and zonation of hepatic genes in cancer-bearing mice. They found that breast cancers affected liver zonation in various distinct manners depending on biological pathways.

Cell and Cell-Derivative-Based Therapy for Liver Diseases; Current Approaches and Future Promises

[Expert Review Of Gastroenterology & Hepatology] Owing to several shortcomings like finite numbers of healthy organ donors, lifelong immunosuppression, and complexity of orthotopic liver transplantation, cell and cell-derivities therapies have emerged as a potential therapeutic alternative for a broad range of liver diseases.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!