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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
ISG15 Deficiency in Hepatic Stellate Cells Promotes TGFĪ²2-Induced Liver Fibrosis by Counteracting CREB1 ISGylation
[Gut] Researchers examined the role of interferon-stimulated gene 15 (ISG15) in the activation of hepatic stellate cells and liver fibrosis.
Tfr2 Is Necessary for Acute Iron-Dependent Hepcidin Induction in Mice with Tfr1-Deficient Hepatocytes
[Blood] Investigators generated transferrin receptor (Tfr)cAlb-Cre;Tfr2Alb-Cre mice with hepatocyte-specific ablation of both Tfr1 and Tfr2 to study their effects on iron homeostasis.
Ligustilide Alleviates Hepatic Fibrosis by Targeting the Mesenchymal Homeobox 1 (MEOX1)- Transcriptional Enhanced Associate Domain Factor 2 (TEAD2) Signalling Axis
[British Journal of Pharmacology] The authors investigated if ligustilide can ameliorate hepatic fibrosis by targeting MEOX1 and exploring the underlying mechanism.
lncRNA, miRNA, and mRNA Dynamics in Cholangiocyte-to-Immature Hepatocyte Differentiation in Liver Regeneration
[Scientific Data] Scientists established the liver ductal organoids from three C57BL/6 mice, and induced the differentiation of cholangiocyte into immature hepatocyte to carry out the transcriptome sequencing.
Atractylon Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis with Increasing SLC39A14 Expression
[Scientific Reports] Researchers evaluated the antitumor activity of Atractylon, a bioactive molecule extracted from a Chinese herb of the genus Atractylodes. The results showed Atractylon inhibited proliferation of HCC cells by arresting them at G2/M phase of cell cycle and suppressed their migration and invasion.
The Circadian Gene CHRONO Drives Hepatocellular Carcinoma Proliferation via G1/S Cell Cycle Transition
[Biochemical and Biophysical Research Communications] Investigators provided the first functional evidence that CHRONO acts as a pro-proliferative regulator in HCC, suggesting that modulation of CHRONO may suppress tumor growth.
The Role of E3 Ubiquitin Ligases and Deubiquitinating Enzymes in Hepatocellular Carcinoma
[Cell Biology and Toxicology] Scientists elaborate on the functions of key ubiquitin ligases (E3) of MDM2, Ī²-TrCP, and SCF complexes, which modulate cell cycle progression, apoptosis, metabolic reprogramming, and drug resistance in HCC.
USC Researchers Launch Study of the Most Complex Lab-Grown Kidney Structures
[Keck School of Medicine of USC] A $2.1 million grant from CIRM supports the new project designed to understand how mature lab-grown kidney structures, which combine the kidneyās filtering and urine-collecting components, can improve the study of disease and development of therapies.
JOSD1 Drives Hepatocellular Carcinoma Malignancy by Modulating the Ubiquitination-Lactylation Switch on PGAM1
[Gut] Researchers elucidated the function of the deubiquitinase JOSD1 in modulating post-translational modification crosstalk and its impact on tumour glycolysis, progression, and immunotherapy response in HCC.
FXR-YAP Signalling Maintains Biliary Epithelial Cell Identity and Preserves Liver Homeostasis
[Nature Metabolism] Investigators showed that biliary epithelial cells safeguard biliary barrier integrity and restrain bile acid-induced fibrogenesis through a cell-intrinsic mechanism involving farnesoid-X-receptor (FXR)āYAP signaling.
Targeting of the Nuclear RNA Exosome to Chromatin by HP1 Affects the Transcriptional Programs of Liver Cells
[Nature Communications] The authors uncovered a direct interaction between heterochromatin protein 1 (HP1) and nuclear RNA exosome complexes, major RNA decay machineries.
Mitochondrial Fusion Heterogeneity Drives Bidirectional Tumor Phenotypic Transition in Combined Hepatocellular-Cholangiocarcinoma
[Proceedings of the National Academy of Sciences of the United States of America] Scientists induced mosaic impairment of mitochondrial fusion in mouse liver under tumorigenic conditions and unexpectedly identified the formation of combined hepatocellular-cholangiocarcinoma, a monoclonal tumor displaying features of both HCC and intrahepatic cholangiocarcinoma.
The publications featured inĀ Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
