Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

VEGFA mRNA-LNP Promotes Biliary Epithelial Cell-to-Hepatocyte Conversion in Acute and Chronic Liver Diseases and Reverses Steatosis and Fibrosis

[Communications Biology] Scientists showed in mice that hepatocyte proliferation is spatiotemporally regulated in each liver lobular zone during pregnancy, with transient proliferation of periportal and pericentral hepatocytes during mid and late gestation, respectively.

Hepatoprotective Effects of Aspirin on Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats by Reducing Inflammation Levels and PD-L1 Expression

[Scientific Reports] Researchers clarified whether aspirin exerted its anti-HCC effect by inhibiting PD-L1 expression. The rat model of HCC was established by drinking 0.01% diethylnitrosamine, and aspirin was given by gavage.

RNA Helicase DDX5 Modulates Sorafenib Sensitivity in Hepatocellular Carcinoma via the Wnt/β-Catenin–Ferroptosis Axis

[Cell Death & Disease] Researchers elucidated the role of DDX5 in sensitizing HCC to sorafenib, offering new therapeutic strategies.

The C-type Lectin COLEC10 Is Predominantly Produced by Hepatic Stellate Cells and Involved in the Pathogenesis of Liver Fibrosis

[Cell Death & Disease] Investigators found the C-type lectins including Colec10 and Colec11 were not produced by hepatocytes but predominantly produced by hepatic stellate cells, especially quiescent ones in the mice livers. In vitro overexpression of COLEC10 in LX-2 cells promotes the mRNA expression of extracellular matrix components including COL1A1, COL1A2 and COL3A1 and the extracellular matrix degradation enzyme MMP2.

Algernon Pharmaceuticals Receives Notice of Intention to Grant from Chinese Patent Office for Repirinast to Treat NASH and NAFLD

[Algernon Pharmaceuticals, Inc.] Algernon Pharmaceuticals, Inc. announced that it had received a notice of intention to grant from the Chinese Patent Office for patent applicationentitled “Compositions and Methods for Treating Non-Alcoholic Steatohepatitis” with NP-251.

Ergothioneine Suppresses Hepatic Stellate Cell Activation via Promoting Foxa3-Dependent Potentiation of the Hint1/Smad7 Cascade and Improves CCl4-Induced Liver Fibrosis in Mice

[Food & Function] Scientists reported that in LX-2 HSCs, ergothioneine upregulated the expression of Hint1 and Smad7 and suppressed their activation provoked by TGFβ1.

Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

[Advanced Science] The suitability of the microfluidic device for dynamic 3D cell culture was tested by growing human hepatocytes in the device under controlled fluid flow for a 14-day period.

Identification and Validation of Candidate Clinical Signatures of Apolipoprotein L Isoforms in Hepatocellular Carcinoma

[Scientific Reports] Apolipoprotein isoforms were explored for their associations with HCC. Diagnostic, and prognostic significance and mechanisms were explored using GSE14520 cohorts from The Cancer Genome Atlas database.

VEGFA mRNA-LNP Promotes Biliary Epithelial Cell-to-Hepatocyte Conversion in Acute and Chronic Liver Diseases and Reverses Steatosis and Fibrosis

[Cell Stem Cell] To overcome this hurdle, scientists proposed vascular-endothelial-growth-factor A (VEGFA) as a therapeutic means to accelerate biliary epithelial-cell-to-hepatocyte conversion.

Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis

[ACS Nano] Researchers developed an hepatic stellate cell- and microbiome-specific delivery system for Dihydrotanshinone I by conjugating prebiotic-like cyclodextrin with vitamin A, utilizing PEG2000 as a linker.

GPNMB+Gal-3+ Hepatic Parenchymal Cells Promote Immunosuppression and Hepatocellular Carcinogenesis

[EMBO Journal] A comprehensive single-cell transcriptome sequencing was applied to profile rat models of toxin-induced liver tumorigenesis and HCC patients.

METTL9-SLC7A11 Axis Promotes Hepatocellular Carcinoma Progression Through Ferroptosis Inhibition

[Cell Death Discovery] Researchers showed that methyltransferase-like proteins 9 (METTL9) expression was elevated in HCC, and its high expression was associated with poor survival outcomes. Knockdown of METTL9 observed a significant inhibition of HCC cell viability, migration, and invasion both in vitro and in vivo.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!