Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Tracking Dynamic Variations of Reactive Oxygen Species and Temperature during Ferroptosis-Induced Hepatic Stellate Cell Activation

July 2, 2026

[ACS Nano] Researchers uncovered a reactive oxygen species-mediated crosstalk between ferroptotic liver cancer cells and hepatic stellate cells that may promote liver fibrosis.

Therapeutic Targeting of AREL1 in Hepatic Stellate Cells Attenuates MASH-Related Liver Fibrosis

July 2, 2026

[Nature Communications] Scientists identified AREL1 as a key driver of hepatic stellate cell activation in MASH-related fibrosis and showed that targeted AREL1 silencing with vitamin A–guided nanoparticles significantly reduces liver fibrosis.

EGFR N-Glycosylation Catalyzed by NDST2 Promotes Lenvatinib Resistance in Hepatocellular Carcinoma

July 2, 2026

[Cancer Research] Using patient-derived organoids (PDOs) and orthotopic HCC xenograft models, investigators uncovered a role for EGFR in lenvatinib resistance.

Postoperative Exosomal Mir-1246 Fuels Hepatocellular Carcinoma Metastasis via BMP9-SMAD7 Axis Suppression

July 2, 2026

[Cancer Letters] The authors found that HCC cells cultured with postoperative serum exhibited enhanced anoikis resistance, invasion, migration, and increased potential for lung metastasis compared to those cultured with preoperative serum.

Proteolytic EphA2 Fragments Cooperatively Promote Hepatocellular Carcinoma Progression

July 2, 2026

[Cell Death & Disease] Scientists investigated their roles in hepatocarcinogenesis and malignant progression. Western blotting and membrane biotinylation assays revealed that EphA2-C-terminal fragment was present in HCC cells co-expressing EphA2 and MT1-MMP.

Hypoimmunogenic iPSC-Derived Hepatic Organoids Featuring a Functional Vascular Network

July 2, 2026

[Scientific Reports] Researchers combined tissue engineering with hypoimmunogenic iPSC technology to generate off-the-shelf hepatic organoids that integrate parenchymal and non-parenchymal cells.

CNOT9 Affects Hepatocellular Carcinoma Proliferation and Cell Cycle through the PTEN/AKT/P53 Signaling Pathway

July 2, 2026

[Human Cell] Investigators identified CCR4-NOT transcription complex subunit 9 (CNOT9) as a driver of liver cancer progression, promoting proliferation and cell cycle progression through the PTEN/AKT/p53 signaling pathway.

Unveiling the Role of Aldosterone in Metabolic Dysfunction-Associated Steatotic Liver Disease

July 2, 2026

[Reviews in Endocrine & Metabolic Disorders] Scientists investigate aldosterone's role in metabolic dysfunction, linking it to adipose tissue dysfunction, systemic insulin resistance, and the development and progression of metabolic dysfunction–associated steatotic liver disease.

Stravitz‑Sanyal Liver Institute at VCU Opens Clinical Research Imaging Center to Advance Liver Disease Treatments

July 2, 2026

[Virginia Commonwealth University] A new imaging center at the Stravitz‑Sanyal Institute for Liver Disease and Metabolic Health at Virginia Commonwealth University will help researchers develop better treatments for liver disease

A First-in-Class Pulsatile FXR Agonist for Bile-Acid-Related Liver Diseases

June 19, 2026

[Nature] Researchers developed linafexor, a first-in-class pulsatile farnesoid X receptor (FXR) agonist that mimics natural bile acid signaling, delivering potent liver disease benefits while avoiding the toxicity associated with sustained FXR activation.

Unraveling the HGF/MET Axis in Mallory-Denk Body Pathogenesis Associated with Liver Fibrosis through Single-Cell Transcriptomics

June 19, 2026

[Signal Transduction and Targeted Therapy] Using single-nucleus RNA sequencing, researchers identified significant cellular heterogeneity and a distinct hepatocyte subpopulation, termed Mallory-Denk body-associated hepatocytes.

S100A10-ANXA2 Tetramer Inhibition Hampers Hepatic Stellate Cell Activation in Human MASLD Organoids

June 19, 2026

[EMBO Molecular Medicine] Investigators inhibited A2t using its inhibitor, A2ti-1, in human hepatic stellate cells and in human multilineage liver organoids modeling Metabolic dysfunction-Associated Steatotic Liver Disease.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!