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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
HepaRegeniX Doses First Patient in Phase Ib Trial with Small Molecule Inhibitor HRX-215 to Promote Liver Regeneration
[HepaRegeniX (GlobeNewswire)] HepaRegeniX announced that the first patient has been dosed in their Phase Ib clinical trial of its lead candidate HRX-215. The trial is evaluating the safety and efficacy of HRX-215, an orally available small-molecule inhibitor of MKK4, in patients undergoing partial liver resection due to liver metastases deriving from colorectal cancer.
US FDA Approves Expanded Indication for AbbVie’s MAVYRET® (Glecaprevir/Pibrentasvir) as First and Only Treatment for People with Acute Hepatitis C Virus
[AbbVie ] AbbVie announced that the US FDA approved a label expansion for MAVYRET®, an oral pangenotypic direct acting antiviral therapy. It is now approved for the treatment of adults and pediatric patients three years and older with acute or chronic hepatitis C virus infection without cirrhosis or with compensated cirrhosis.
Hepatitis B Virus Core Protein Promotes Liver Cancer Progression by Stabilizing CANX and Suppressing IRF7 Transcription
[Acta Pharmaceutica Sinica B] Investigators showed that the expression of calnexin was significantly increased in hepatitis B virus-associated liver cancer, and its upregulation was relevant to the unfavorable survival of patients with the tumor.
TERN-501 Monotherapy and Combination Therapy with TERN-101 in Metabolic Dysfunction-Associated Steatohepatitis: The Randomized Phase IIa DUET Trial
[Nature Medicine] DUET was a 12-week, randomized, double-blind, placebo-controlled, multicenter Phase IIa study investigating the efficacy, safety, and pharmacodynamics and pharmacokinetics of once-daily TERN-501 as monotherapy or combined with TERN-101, in patients with presumed metabolic dysfunction-associated steatohepatitis.
Reproductive State Controls Transcription in the Murine Liver, with Implications for Breast Cancer Liver Metastasis
[Proceedings of The National Academy of Sciences of The United States of America] Investigators employed transcriptomic profilingg and identified elevated hepatocyte proliferation and anabolic metabolism gene signatures during lactation, consistent with the liver being a major producer of substrates needed for milk production.
Immunopathogenic Mechanisms and Immunoregulatory Therapies in MASLD
[Cellular & Molecular Immunology] Scientists provide an in-depth discussion of current data related to the immunological mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) and summarize the effects of current and experimental therapies on immunoregulation in MASLD.
Endoplasmic Reticulum Stress Sensor Protein PERK in Hepatic Stellate Cells Promotes the Progression of Hepatocellular Carcinoma via P38δ MAPK/IL-1β Axis
[Scientific Reports] Researchers clarified the process of IL-1β production via PERK in hepatic stellate cells and explored the mechanism underlying MASH-related HCC progression.
Cholangiocytes Contribute to Hepatocyte Regeneration after Partial Liver Injury during Growth Spurt in Zebrafish
[Nature Communications] Researchers designed two partial liver injury models in zebrafish, which were investigated during growth spurts: 1) partial ablation, killing half the hepatocytes; and 2) partial hepatectomy, removing half a liver lobe. In both injuries, de novo hepatocytes emerg alongside existing ones.
The Hepatocyte Traffic Network in the Human Hepatitis a Virus Biological Cycle from an Evolutionary Perspective
[Communications Biology] Scientists proposed that hepatocytes cloaked in exosomes biogenesis may follow not only an endosomal sorting complex required for transport-mediated pathway but also the syndecan-syntenin-ALIX pathway.
Immune Microenvironment in Hepatocellular Carcinoma: From Pathogenesis to Immunotherapy
[Cellular & Molecular Immunology] The authors discuss the latest findings shedding light on the direct or indirect roles of immune cells and fibroblastic-like cells, such as hepatic stellate cells, in the pathogenesis of HCC.
A Novel Oncogene, Leucine-Rich Repeat Protein 1, Mediates Hypoxia-Induced Hepatocellular Carcinoma Progression
[Functional & Integrative Genomics] With findings in bioinformatic analysis, researchers further validated the involvement of leucine rich repeats protein 1 (LRR1) in HCC progression by cellular experiments. The expression of LRR1 is significantly upregulated in HCC compared to normal liver tissues and cell line.
Liver Macrophages: Development, Dynamics, and Functions
[Cellular & Molecular Immunology] The authors discuss the major populations of macrophages resident in the liver, their location, functions, development, and role in maintaining the liver in the face of injury and infection.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
