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Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Clinical Outcomes and Histologic Findings of Patients With Hepatocellular Carcinoma With Durable Partial Response or Durable Stable Disease After Receiving Atezolizumab Plus Bevacizumab
[International Journal of Clinical Oncology] The IMbrave150 study's atezo-bev group was analyzed. PR or SD per RECIST v1.1 lasting more than 6 months was defined as durable. For histologic analysis, a comparable real-world group of patients from Japan and Taiwan who had undergone resection of residual tumors after atezo-bev was investigated.
An Atlas of the Human Liver Diurnal Transcriptome and Its Perturbation by Hepatitis C Virus Infection
[Nature Communications] Investigators unravelled the rhythmic transcriptome and epigenome of human hepatocytes using male human liver chimeric mice.
Donation of Asia’s First World-Class Medical Device to the HKU Li Ka Shing Faculty of Medicine Histotripsy Technology: A Non-Invasive, Painless, Highly Efficient Surgery...
[The University of Hong Kong] With a generous donation from the Li Ka Shing Foundation, the LKS Faculty of Medicine at the University of Hong Kong will be the first institution in Asia to introduce the groundbreaking Histotripsy system, using state-of-the-art histotripsy technology for clinical trials, offering Hong Kong liver cancer patients access to non-invasive, painless and highly effective treatment.
SLC13A3 Is a Major Effector Downstream of Activated β-Catenin in Liver Cancer Pathogenesis
[Nature Communications] Scientists identified SLC13A3 as a drug-targetable effector downstream of β-catenin in liver cancer. SLC13A3 expression was elevated in human liver cancer samples with gain of function mutant CTNNB1, the gene encoding β-catenin.
Patient-Derived Organoid Models to Decode Liver Pathophysiology
[Trends In Endocrinology and Metabolism] Investigators discuss state-of-the-art patient-derived liver organoid models, recent technological advancements, and strategies to enhance their clinical impact.
Glucagon Promotes Increased Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Humans with Fatty Liver Disease
[Cell Metabolism] Researchers assessed in vivo rates of hepatic mitochondrial oxidation, gluconeogenesis, and β-hydroxybutyrate turnover by positional isotopomer NMR tracer analysis in individuals with metabolic-dysfunction-associated steatotic liver (MASL) and MASL disease compared with BMI-matched control participants with no hepatic steatosis.
Global Isonicotinylome Analysis Identified SMAD3 Isonicotinylation Promotes Liver Cancer Cell Epithelial–Mesenchymal Transition and Invasion
[iScience] Using proteomic technology, the authors identified 11,442 Kinic sites across 2,792 proteins and demonstrated that Kinic of non-histone proteins is involved in multiple function pathways.
Efficacy and Safety of Resmetirom, a Selective Thyroid Hormone Receptor-β Agonist, in the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Systematic Review...
[Scientific Reports] Authors conducted a systematic review and meta-analysis aimed to evaluate the effectiveness and safety of resmetirom compared to a placebo in the treatment of MASLD.
DRD4 Promotes Chemo-Resistance and Cancer Stem Cell-Like Phenotypes by Mediating the Activation of the Akt/β-Catenin Signaling Axis in Liver Cancer
[British Journal of Cancer] To investigate the gene and protein expression profiles of DRD4 in liver cancer stem cells (LCSCs) and non-LCSCs, we utilized transcriptome sequencing and Western blotting analysis. Bioinformatics analysis and immunohistochemistry were employed to assess the correlation between DRD4 expression levels and the pathological characteristics of liver cancer patients.
A Broadly Cross-Reactive I-Body to AMA1 Potently Inhibits Blood and Liver Stages of Plasmodium Parasites
[Nature Communications] Scientists identified an i-body, a humanised single-domain antibody-like molecule that recognises a conserved pan-species conformational epitope in AMA1 with low nanomolar affinity and inhibits the binding of the RON2 ligand to AMA1.
PCPE-1, a Brown Adipose Tissue-Derived Cytokine, Promotes Obesity-Induced Liver Fibrosis
[EMBO Journal] The authors identified the secreted-type pro-fibrotic protein, procollagen C-endopeptidase enhancer-1 (PCPE-1), as a brown adipose tissue (BAT)-derived adipokine that promotes liver fibrosis in a murine obesity-induced MASH model. BAT-specific or systemic PCPE-1 depletion in mice ameliorated liver fibrosis, whereas, PCPE-1 gain of function in BAT enhanced hepatic fibrosis.
EPDR1 Promotes PD-L1 Expression and Tumor Immune Evasion by Inhibiting TRIM21-Dependent Ubiquitylation of IkappaB Kinase-β
[EMBO Journal] Researchers identified ependymin-related protein 1 (EPDR1) as an important tumor-intrinsic regulator of PD-L1 expression and tumor immune evasion.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
