Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

MiR204 Potentially Promotes Non-Alcoholic Fatty Liver Disease by Inhibition of cpt1a in Mouse Hepatocytes

[Communications Biology] The expression of miR204 was increased in mice with isocitrate dehydrogenase deficiency, which regulated carnitine palmitoyltransferase 1a (cpt1a) synthesis, inhibiting fatty acid β-oxidation.

Glial Cell Derived Neurotrophic Factor Prevents Western Diet and Palmitate-Induced Hepatocyte Oxidative Damage and Death through SIRT3

[Scientific Reports] Researchers found that western diet (WD)-feeding increased hepatic lipid peroxidation in control mice and, ,in vitro palmitate induced oxidative stress and impaired the mitophagic clearance of damaged mitochondria in hepatocytes.

FASN Inhibition Targets Multiple Drivers of Nash by Reducing Steatosis, Inflammation and Fibrosis in Preclinical Models

[Scientific Reports] Researchers tested pharmacological inhibition of fatty acid synthase (FASN) in human cell culture and in three diet induced mouse models of NASH.

Emerging Role of Carboxylesterases in Nonalcoholic Fatty Liver Disease

[Biochemical Pharmacology] The authors provide an overview of the relationship between carboxylesterases (CESs) and NAFLD, and discuss the role and potential value of CESs in the treatment and prevention of NAFLD.

MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling To Facilitate Metastasis in Hepatocellular Carcinoma

[Cancer Research] Researchers investigated whether RNA binding proteins (RBPs) were important regulators of HCC metastasis.The RBP MEX3C was found to be significantly upregulated in highly metastatic HCC and correlated with poor prognosis in HCC.

Melanoma Differentiation Associated Gene-9/Syndecan Binding Protein (MDA-9/SDCBP) Promotes Hepatocellular Carcinoma

[Hepatology] To unravel the function of MDA-9 in HCC, scientists generated and characterized a transgenic mouse with hepatocyte-specific overexpression of MDA-9.

ncRNAs-Mediated High Expression of TICRR Promotes Tumor Cell Proliferation and Migration and Is Correlated With Poor Prognosis and Tumor Immune Infiltration of Hepatocellular Carcinoma

[Molecular Therapy-Nucleic Acids] Scientists demonstrated through a series of experiments that TICRR facilitated the proliferation and metastasis of liver cancer cells in vitro.

Vaccination-Based Immunotherapy To Target Profibrotic Cells in Liver and Lung

[Cell Stem Cell] Researchers tested whether specific immunization against endogenous proteins, strongly expressed in fibrogenic cells but highly restricted in quiescent fibroblasts, could elicit an antigen-specific cytotoxic T cell response to ameliorate organ fibrosis.

Preclinical Investigation of Artesunate as a Therapeutic Agent for Hepatocellular Carcinoma via Impairment of Glucosylceramidase-Mediated Autophagic Degradation

[Experimental and Molecular Medicine] Experiments revealed an association between autophagic activity and glucosylceramidase expression in clinical HCC samples, tumor tissues from a rat model of inflammation-induced HCC, an orthotopic mouse model, and human HCC cell lines.

Interleukin-33 Facilitates Liver Regeneration through Serotonin-Involved Gut-Liver Axis

[Hepatology] The authors investigated the role of interleukin-33 in liver regeneration after partial hepatectomy, to elucidate its underlying mechanisms.

Immunobiology of the Biliary Tract System

[Journal of Hepatology] The author provides an overview of emerging knowledge on the immunobiology of the biliary tract system, with a particular emphasis on the role of distinct immune cells in biliary disorders.

Inside the New Institute Looking at Early Cancer

[University of Cambridge] The Institute will see as many as 120 scientists from a broad spectrum of disciplines across the University – working together under one roof to understand the fundamental biology of how cancer develops and how it evolves, and applying that knowledge to pioneer new methods.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!