Scientists explored the efficacy of two protocols to decellularize porcine liver tissue using varying combinations of commonly used chemical agents such as Triton X-100, Sodium Dodecyl Sulphate and ammonium hydroxide.
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Scientists review current models of multidisciplinary care teams and introduce a framework for building a comprehensive NAFLD program based on real-world experience within their institution.
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The authors highlight how lipids, carbohydrates, and proteins dynamically change and orchestrate liver regeneration. They discuss translational studies in which metabolic intervention has been used to treat chronic liver diseases.
[Trends in Endocrinology and Metabolism]
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Researchers discuss how the hepatic microenvironment adapts to pathologies characterized by chronic inflammation and metabolic alterations. They illustrate how these immunological or metabolic changes alter immunosurveillance and thus hinder or promote the development of primary liver cancer.
[Nature Reviews Cancer]
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Arrowhead Pharmaceuticals, Inc. announced that it was granted Breakthrough Therapy designation by the US FDA for ARO-AAT, also known as TAK-999, the company’s second-generation investigational RNA interference therapeutic being co-developed with Takeda Pharmaceutical Company Limited as a treatment for the rare genetic liver disease associated with alpha-1 antitrypsin deficiency.
[Arrowhead Pharmaceuticals, Inc. (BusinessWire, Inc.)]
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Through overexpressing TMEM220 in hepatocellular carcinoma cell lines, scientists found that the proliferation of cancer cells was significantly slowed down and metastasis was significantly reduced.
[Cancer Gene Therapy]
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Researchers explored the mechanistic role of super-enhancers linking cytokine TNFα with chemokine amplification in alcoholic hepatitis.
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Scientists identified the role of tribbles homolog 2 (TRIB2) to relieve oxidative damage via reducing the availability of ubiquitin that was essential for the ubiquitination and subsequent degradation of glutathione peroxidase 4.
[Cell Death Discovery]
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In a subset of 94 patients with hepatocellular carcinoma (HCC), a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor.
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In the presence of NOXA, BIM-deficient hepatocellular carcinoma cells could be in turn strongly sensitized for cell death induction by the combination of sorafenib with TNF-related apoptosis-inducing ligand .
[Cell Death & Disease]
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Researchers reported that SET and MYND domain-containing protein 3 (SMYD3) expression in hepatocellular carcinoma (HCC) was an independent prognostic factor for survival and promoted the proliferation and migration of HCC cells.
[Cell Death & Disease]
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