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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Molecular Mechanisms in Liver Repair and Regeneration: From Physiology to Therapeutics
[Signal Transduction and Targeted Therapy] The authors link molecular insights to therapeutic frontiers, systematically charting the trajectory from fundamental physiological mechanisms to innovative clinical applications in liver repair and regeneration.
Hepatocellular Carcinoma: Signaling Pathways and Therapeutic Advances
[Signal Transduction and Targeted Therapy] The authors provide a comprehensive review of cellular signaling pathways, their therapeutic potential, and the development of more effective therapeutics for HCC.
Hyodeoxycholic Acid Ameliorates Cholestatic Liver Fibrosis by Facilitating m6A-Regulated Expression of a Novel Anti-Fibrotic Target ETV4
[Journal of Hepatology] Researchers evaluated protective effects of hyodeoxycholic acid (HDCA) against cholestatic liver fibrosis and explored whether ETV4 was a novel anti-fibrotic target involving in the therapeutic effects of HDCA.
The Anti-PD-L1/CTLA-4 Bispecific Antibody KN046 plus Lenvatinib in Advanced Unresectable or Metastatic Hepatocellular Carcinoma: A Phase II Trial
[Nature Communications] Investigators evaluated the efficacy and safety of KN046 combined with lenvatinib in patients with advanced HCC, and explored the potential response biomarkers.
Retrograde Mitochondrial Signaling Governs the Identity and Maturity of Metabolic Tissues
[Science] The authors reported that dysfunctional mitochondrial quality control engaged a retrograde signaling program that impaired cellular identity and maturity in β-cells, hepatocytes, and brown adipocytes.
Differential Transport Pathways of Saturated and Unsaturated Fatty Acid Esters in Male Mouse Hepatocytes
[Nature Communications] Scientists found the secretion of unsaturated fatty acid but not saturated fatty acid esters was retarded in a male mouse hepatic endoplasmic reticulum stress model.
ALF Announces 2024 Recipients of Liver Scholar and Postdoctoral Research Fellowship Awards
[American Liver Foundation] American Liver Foundation (ALF) announced the recipients of its 2024 Liver Scholar and Postdoctoral Research Fellowship Awards. The ALF Research Program supported 20 early career scientists and cutting-edge research projects in 2024 for a total of $950,000.
Current Landscape of Adoptive Cell Therapy and Challenge to Develop “Off-The-Shelf” Therapy for Hepatocellular Carcinoma
[Journal of Gastroenterology and Hepatology] The authors discuss the current status and promise of adoptive cell therapy (ACT) research in HCC, focusing on challenges in off-the-shelf ACT using primary cells or induced pluripotent stem cells with or without genetic engineering.
Muscle-Derived Small Extracellular Vesicles Induce Liver Fibrosis During Overtraining
[Cell Metabolism] Investigators showed that overtraining induced hepatic fibrosis. Lactate bodies induced hepatocyte apoptosis followed by hepatic stellate cell activation via myeloid cell leukemia sequence 1-BAX/BAK signaling.
Liver Diseases: Epidemiology, Causes, Trends, and Predictions
[Signal Transduction and Targeted Therapy] Scientists highlight the multifaceted mechanisms underlying the initiation and progression of liver diseases, spanning molecular and cellular levels to organ networks.
Periductal Fibroblasts Participate in Liver Homeostasis, Fibrosis, and Tumorigenesis
[Journal of Experimental Medicine] Researchers identified Cd34 and Dpt as hepatic fibroblast–specific genes. Depletion of Cd34+ fibroblasts increased the frequency of the ductal epithelial cells under homeostasis and accelerated the progression of intrahepatic cholangiocarcinoma.
Transcription of Hepatitis B Surface Antigen Shifts from cccDNA to Integrated HBV DNA during Treatment
[Journal of Clinical Investigation] Scientists applied a novel multiplex droplet digital PCR that identified the dominant source of hepatitis B surface antigen mRNAs to 3436 single cells from paired liver biopsies from ten people with chronic hepatitis B and HIV receiving nucleos(t)ide analogues.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
