Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Unraveling the Hepatic Stellate Cells Mediated Mechanisms in Aging’s Influence on Liver Fibrosis

[Scientific Reports] The study involved 32 albino rats categorized into four groups: young controls, young with liver fibrosis, old controls, and old with liver fibrosis. Various parameters including serum ALT, adiponectin, leptin, and cholesterol levels were evaluated.

An Unbiased Ranking of Murine Dietary Models Based on Their Proximity to Human Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

[Nature Metabolism] Researchers showed that Western diets aligned closely with human metabolic dysfunction-associated steatohepatitis (MASH); high cholesterol content, extended study duration and/or genetic manipulation of disease-promoting pathways are required to intensify liver damage and accelerate significant fibrosis development.

MicroRNA-141-Regulated KLK10 and TNFSF-15 Gene Expression in Hepatoblastoma Cells as a Novel Mechanism in Liver Carcinogenesis

[Scientific Reports] Investigators identified the role of miR-141 and its potential functions in liver carcinogenesis. The level of miR-141 in HepG2 and HuH7 cells was assessed using quantitative real-time PCR and compared with its expression in normal hepatocytes.

The HHEX-ABI2/SLC17A9 Axis Induces Cancer Stem Cell-Like Properties and Tumorigenesis in HCC

[Journal of Translational Medicine] Investigators reported that HHEX was a novel CSCs target for hepatocellular carcinoma (HCC). They found that HHEX was overexpressed in HCC tissues and high expression of HHEX was associated with poor survival.

Spaceflight Induces Changes in Gene Expression Profiles Linked to Insulin and Estrogen

[Communications Biology] Scientists found spaceflight induced changes in insulin and estrogen signaling in rodents and humans. Murine changes were most prominent in the liver, where they observed inhibition of insulin and estrogen receptor signaling with concomitant hepatic insulin resistance and steatosis.

A New Label Free Spiral Sensor Using Impedance Spectroscopy to Characterize Hepatocellular Carcinoma in Tissue and Serum Samples

[Scientific Reports] Investigators developed a spiral sensor implemented on a printed circuit board technology that utilized impedance spectroscopy and applied it to 24 tissues and sera samples as proof of concept.

MLK3 Promotes Prooncogenic Signaling in Hepatocellular Carcinoma via TGFβ Pathway

[Oncogene] To understand MLK3’s role in HCC, researchers utlized carcinogen-induced HCC model and compared between wild-type and MLK3 knockout mice. Their studies showed that MLK3 kinase activity is upregulated in HCC, and MLK3 deficiency alleviates HCC progression.

Alantolactone Attenuates High-Fat Diet-Induced Inflammation and Oxidative Stress in Non-Alcoholic Fatty Liver Disease

[Nutrition & Diabetes] C57BL/6 mice were fed a high-fat diet (HFD) to induce NAFLD. After 16 weeks, Ala was administered by gavage to observe its effect on NAFLD. RNA sequencing of liver tissues was performed to investigate the mechanism.

Lipotoxic Hepatocyte Derived LIMA1 Enriched Small Extracellular Vesicles Promote Hepatic Stellate Cells Activation via Inhibiting Mitophagy

[Cellular & Molecular Biology Letters] High-fat diet (HFD) mice model was constructed to confirm the expression of LIMA1. The relationship between LIMA1-enriched LTH-small extracellular vesicles and LX2 activation was evaluated by measurement of fibrotic markers and related genes.

CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects

[Advanced Science] CD9 was decreased in the fatty livers of patients and upregulated upon glucagon receptor activation. Deficiency of CD9 in the liver exacerbated diet-induced hepatic steatosis via complement factor D regulated fatty acid metabolism.

SNX16 Is Required for Hepatocellular Carcinoma Survival via Modulating the EGFR-AKT Signaling Pathway

[Scientific Reports] Researchers delved into SNX16’s regulation of the EGFR-AKT signaling cascade mechanism. SNX16 overexpression in HCC correlated with poor patient survival; enhancing proliferation, migration, invasion, and tumorigenicity, while SNX16 knockdown suppressed these processes.

£30M Clinical Study Will Enhance the Understanding of NASH Cirrhosis

[MSN] The most extensive clinical study into liver cirrhosis ever conducted worldwide has been announced by Newcastle University, University of Edinburgh and leading research-driven global biopharmaceutical company, Boehringer Ingelheim.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!