Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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Unraveling CD8 Lineage Decisions Reveals That Functionally Distinct CD8+ T Cells Are Selected by Different MHC-I Thymic Peptides

January 23, 2026

[Nature Immunology] The authors reported that encoding CD8 co-receptors in both Cd4 and Cd8 gene loci modulates major histocompatibility complex class I T cell antigen receptor signaling duration to generate all potential CD8+ T cell subsets.

Regulatory T-Cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth

January 23, 2026

[Cancer Immunology Research] In a murine lung cancer model induced by Lewis lung carcinoma cells, scientists found that P2RX7 enhanced the suppressive capacity of tumor-infiltrating Tregs, promoting tumor growth.

Congress Set to Restore $10 Million in Funding for Lupus Research

January 20, 2026

[Lupus Research Alliance] The Lupus Research Alliance announced major legislative wins on behalf of the lupus community in the recently-introduced federal spending bill. The spending bill restores $10 million for the Department of Defense Lupus Research Program and protects robust investment in the National Institutes of Health.

The Aryl Hydrocarbon Receptor: Structure, Signaling, Physiology, and Pathology

January 16, 2026

[Signal Transduction and Targeted Therapy] The authors review the involvement of aryl hydrocarbon receptor in pathologies such as cancer and autoimmune and inflammatory diseases and its potential as a therapeutic target.

TRIP13 Promotes the Expansion and Immunosuppression of CD4Foxp3 Regulatory T Cells by Sustaining HAT1 Stability

January 16, 2026

[Cell Death & Disease] Using RNA-seq profiling of TNFR2+ and TNFR2-deficient Treg cells, researchers identified that Trip13 is required for promoting TNF-TNFR2 pathway-mediated Treg expansion.

Reprogramming Immunity to Rewrite the Story of Type 1 Diabetes

January 16, 2026

[Medical University of South Carolina] With $1 million in funding from Breakthrough T1D, Dr. Leonardo Ferreira and his collaborators will explore a new approach to treating type 1 diabetes. Dr. Ferreira brings to the field his expertise in engineering the immune system by creating chimeric antigen receptors, that help Tregs to find their targets.

Coya Therapeutics Announces Results of Investigator-Initiated Study of LD IL-2 and CTLA4-Ig Demonstrating Treg Enhancement and Cognitive Stability in Frontotemporal Dementia Patients

January 16, 2026

[Coya Therapeutics, Inc. ] Coya Therapeutics, Inc. announced positive results of an investigator-initiated proof of concept open-label study with low-dose IL-2 and CTLA4-Ig combination treatment in nine patients with Frontotemporal Dementia. Data demonstrated enhanced Treg numbers and function and cognitive function stability.

Microbiota-Induced T Cell Plasticity Enables Immune-Mediated Tumor Control

January 14, 2026

[Nature] Scientists used a gut commensal microorganism, segmented filamentous bacteria (SFB), to investigate how colonization with this microbe affects the efficacy of immune checkpoint blockade in restraining distal growth of tumours sharing antigen with SFB.

Intermittent Ketogenic Diet Promotes Treg Differentiation and Alleviates Crohn’s Disease via the β-Hydroxybutyrate Driven AHCY-DNMT1-Foxp3 Axis

January 14, 2026

[Journal of Crohn'S & Colitis] In an IL-10 knockout model, scientists reported that an intermittent ketogenic diet improves intestinal barrier function and reshapes the gut microbiota.

Neutrophils As Critical Orchestrators of Chronic Inflammation

January 13, 2026

[Cellular & Molecular Immunology] Increasing knowledge on neutrophil behavior in the context of chronic inflammation may offer novel insights into disease pathology and, potentially, the identification of novel therapeutic targets.

RAS/MEK/PI3K Pathway Inhibition Augments Response to CD40 Agonism by Targeting CD11b+ Bregs Thereby Overcoming Melanoma PD1-Resistance

January 13, 2026

[Nature Communications] Scientists showed that combined treatment with a RAS/PI3K/AKT-pathway inhibitor rigosertib, and/or a MEK1/2 inhibitor trametinib, plus aCD40, overcomes the immune checkpoint blockade resistance of BRAFwtNRASwt and BRAFwtNRASmut melanoma tumors growing in C57BL/6 mice.

Stability and Progressive Differentiation of TFR Cells Are Intrinsically and Extrinsically Controlled by TFH Programs

January 13, 2026

[Nature Immunology] Investigators found that follicular regulatory T cells undergo progressive differentiation through progenitor, early effector, and late effector stages.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.