Modulation of Preeclampsia by the Cholinergic Anti-Inflammatory Pathway: Therapeutic Perspectives

Investigators summarize reports in the literature regarding the roles of peripheral and reflex cholinergic neuroinflammatory pathways of nicotinic acetylcholine receptors in reprogramming preeclampsia complications in mothers and their progenies.
[Biochemical Pharmacology]
Wedn, A. M., El-Bassossy, H. M., Eid, A. H., & El-Mas, M. M. (2021). Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives. Biochemical Pharmacology, 192, 114703. https://doi.org/10.1016/j.bcp.2021.114703 Cite
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The Role of Interleukin-1β in the Immune Response to Contact Allergens

The authors summarize the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD.
[Contact Dermatitis]
Yeung, K., Mraz, V., Geisler, C., Skov, L., & Bonefeld, C. M. (n.d.). The role of interleukin-1β in the immune response to contact allergens. Contact Dermatitis, n/a(n/a). https://doi.org/10.1111/cod.13955 Cite
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Revolo Biotherapeutics Announces Clinical Trial Authorization to Initiate Phase II Trial of ‘1104 in Allergic Disease in the UK

Revolo Biotherapeutics announced receipt of Clinical Trial Authorization by the Medicines and Healthcare Products Regulatory Agency in the UK to evaluate safety and efficacy of its first-in-class peptide for the treatment of allergic disease, ‘1104, in a Phase II allergen sensitivity study.
[Revolo Biotherapeutics]
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Beyond Celiac Partners with University of Sheffield, UK, to Research Neuropathology of Celiac Disease and Gluten-Related Disorders

Beyond Celiac announced the granting of a two-year established investigator grant award to the University of Sheffield, United Kingdom. The $209,000 investment from Beyond Celiac will make it possible for scientists to expand investigation of the neurological and neuropsychological manifestations of celiac disease and gluten-related disorders.
[Beyond Celiac]
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Hijacking TYRO3 from Tumor Cells via Trogocytosis Enhances NK-Cell Effector Functions and Proliferation

Investigators found that although NK cells did not express endogenous TYRO3 on the cell surface, activated NK cells rapidly acquired TYRO3 from tumor cells via trogocytosis in vitro and in vivo.
[Cancer Immunology Research]
Lu, T., Ma, R., Li, Z., Mansour, A. G., Teng, K.-Y., Chen, L., Zhang, J., Barr, T., Caligiuri, M. A., & Yu, J. (2021). Hijacking TYRO3 from tumor cells via trogocytosis enhances NK-cell effector functions and proliferation. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-1014 Cite
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Modulation of Preeclampsia by the Cholinergic Anti-inflammatory Pathway: Therapeutic Perspectives

Investigators summarize reports in the literature regarding the roles of peripheral and reflex cholinergic neuroinflammatory pathways of nicotinic acetylcholine receptors in reprogramming preeclampsia complications in mothers and their progenies.
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Effector Memory CD4+T Cells in Mesenteric Lymph Nodes Mediate Bone Loss in Food-Allergic Enteropathy Model Mice, Creating IL-4 Dominance

Scientists investigated a non-IgE-mediated food-allergic enteropathy model of ovalbumin (OVA) 23-3 mice expressing OVA-specific T-cell-receptor transgenes.
[Mucosal Immunology]
Ono-Ohmachi, A., Yamada, S., Uno, S., Tamai, M., Soga, K., Nakamura, S., Udagawa, N., Nakamichi, Y., Koide, M., Morita, Y., Takano, T., Itoh, T., Kakuta, S., Morimoto, C., Matsuoka, S., Iwakura, Y., Tomura, M., Kiyono, H., Hachimura, S., & Nakajima-Adachi, H. (2021). Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance. Mucosal Immunology, 1–12. https://doi.org/10.1038/s41385-021-00434-2 Cite
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Essential Role of a ThPOK Autoregulatory Loop in the Maintenance of Mature CD4+ T Cell Identity and Function

The authors described a new autoregulatory loop whereby ThPOK bound to the SilThPOK to maintain its own long-term expression in CD4 T cells.
[Nature Immunology]
Basu, J., Reis, B. S., Peri, S., Zha, J., Hua, X., Ge, L., Ferchen, K., Nicolas, E., Czyzewicz, P., Cai, K. Q., Tan, Y., Fuxman Bass, J. I., Walhout, A. J. M., Grimes, H. L., Grivennikov, S. I., Mucida, D., & Kappes, D. J. (2021). Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function. Nature Immunology, 22(8), 969–982. https://doi.org/10.1038/s41590-021-00980-8 Cite
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LRRK2 Is Required for CD38-Mediated NAADP-Ca2+ Signaling and the Downstream Activation of TFEB (Transcription Factor EB) in Immune Cells

Researchers mechanistically and functionally linked CD38 and LRRK2 as upstream activators of TFEB, a host defense transcription factor and the master transcriptional regulator of the autophagy/lysosome machinery.
[Autophagy]
Nabar, N. R., Heijjer, C. N., Shi, C.-S., Hwang, I.-Y., Ganesan, S., Karlsson, M. C. I., & Kehrl, J. H. (2021). LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells. Autophagy, 0(0), 1–19. https://doi.org/10.1080/15548627.2021.1954779 Cite
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STING Suppresses Bone Cancer Pain via Immune and Neuronal Modulation

Investigators reported that agonists of the immune regulator stimulator of interferon genes (STING) confered remarkable protection against cancer pain, bone destruction, and local tumor burden.
[Nature Communications]
Wang, K., Donnelly, C. R., Jiang, C., Liao, Y., Luo, X., Tao, X., Bang, S., McGinnis, A., Lee, M., Hilton, M. J., & Ji, R.-R. (2021). STING suppresses bone cancer pain via immune and neuronal modulation. Nature Communications, 12(1), 4558. https://doi.org/10.1038/s41467-021-24867-2 Cite
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Pax5 Regulates B Cell Immunity by Promoting PI3K Signaling via PTEN Down-Regulation

Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.
[Science Immunology]
Calderón, L., Schindler, K., Malin, S. G., Schebesta, A., Sun, Q., Schwickert, T., Alberti, C., Fischer, M., Jaritz, M., Tagoh, H., Ebert, A., Minnich, M., Liston, A., Cochella, L., & Busslinger, M. (2021). Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation. Science Immunology, 6(61). https://doi.org/10.1126/sciimmunol.abg5003 Cite
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