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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
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Cardiolipin Preserves Treg Metabolic Fitness and Immune Homeostasis in the Gut
[Nature Metabolism] Researchers discovered that deleting the cardiolipin-synthesizing enzyme protein tyrosine phosphatase mitochondrial 1 (PTPMT1) in T cells predisposes mice to colitis due to impaired Treg cell function in the absence of dysbiosis.
Current Status of Treg Therapy in Transplantation and Autoimmune Disease
[Immunology] The authors review preclinical and clinical applications of Treg-based therapies, including adoptive Treg transfer, low-dose IL-2, and CAR-Treg therapy. They discuss their effectiveness in modulating immune responses across diverse pathological contexts.
Dendritic Cells As Orchestrators in the Allergen-Specific Immunotherapy of Allergic Diseases
[Clinical Reviews in Allergy & Immunology] Scientists dissect the multi-layered mechanisms through which dendritic cells orchestrate immune tolerance, spanning cytokine signaling, metabolic reprogramming, epigenetic remodeling, and migratory dynamics.
Chaperone-Mediated Autophagy Is Required for Regulatory T Cell Function
[Nature Communications] Using a Treg-specific chaperone-mediated autophagy (CMA)-deficient mouse model, scientists showed that CMA is crucial for maintenance of peripheral tolerance by Tregs. Mice with CMA-defective Tregs display signs of chronic inflammation, which results in reduced survival as they age.
Runx3 Instructs Aire mTEC Development, TSA Gene Expression, and Central Tolerance
[Journal of Autoimmunity] Researchers uncovered new functions for Runx3 in thymic epithelial lineage development and showed Runx3 expression in medullary thymic epithelial cells (mTECs) is required for both Autoimmune Regulator + (Aire+) mTEC development and tissue-specific antigen (TSA) gene expression.
Helicase A Determines the Transcription Program of T17 Lineage Differentiation and Autoimmunity
[Science Advances] Investigators identified a positive correlation between the expression of Dhx9, a nuclear helicase, and TH17 lineage during the progression of autoimmune diseases.
Foxp3 and BATF Cooperatively Direct Cis-Regulatory Programs and Gene Expression for Effector Treg Cell Differentiation
[Immunity] Scientists showed that the master regulator Foxp3 cooperates with BATF to direct cis-regulatory programs and gene expression essential for the differentiation of immunosuppressive effector Treg cells.
Coya Therapeutics Has Been Granted US FDA Fast Track Designation for COYA 302 for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
[Coya Therapeutics, Inc.] Coya Therapeutics, Inc. announced that the US FDA has granted Fast Track Designation for COYA 302, an investigational biologic combination therapy with a dual mechanism of action, for the treatment of amyotrophic lateral sclerosis (ALS).
CD4+ Tregs Drive Post-Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
[Advanced Science] Scientists found that endothelial cells (ECs) upregulate the transcription factor YY1 during post-ischemic vascular regeneration, but this response is blunted in diabetic ECs. They identifited endothelial YY1 as a mediator through which CD4+ Tregs drive angiogenesis in non-diabetic condition.
The Treg-Cell Death Axis in Lung Cancer: Implications for Immune Evasion and Novel Therapeutic Strategies
[Molecular Cancer] The authors propose the Treg-cell death axis as a unifying framework linking immune tolerance, regulated cell death, and immunotherapy resistance in lung cancer. Targeting this axis through may provide opportunities to overcome therapeutic resistance and improve clinical outcomes.
SAICAR Drives T Regulatory Cell Differentiation and FOXP3 Maintenance to Promote Immunotherapy Resistance
[Cancer Research] Scientists identified the purine biosynthesis intermediate succinylaminoimidazole carboxamide ribose-5′-phosphate (SAICAR) as a key metabolic driver of Treg induction and resistance to anti–PD-1 immunotherapy.
The Long Noncoding RNA Lnc13 Restrains Inflammatory Responses to Maintain Oral Tolerance to Gluten
[Nature Immunology] In HLA-DQ8 transgenic mice lacking lnc13, unmanipulated gluten ingestion led to molecular signatures resembling human celiac disease and hallmark features of loss of oral tolerance to gluten: increased IFN-γ+ lymphocytes, IL-12+ myeloid cells, cytotoxic intraepithelial immune cells, and crypt hyperplasia in the small intestine.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
