Scientists showed that in aging mice myeloid cell bioenergetics were suppressed in response to increased signaling by the lipid messenger prostaglandin E2, a major modulator of inflammation.
[Nature]
Minhas, P. S., Latif-Hernandez, A., McReynolds, M. R., Durairaj, A. S., Wang, Q., Rubin, A., Joshi, A. U., He, J. Q., Gauba, E., Liu, L., Wang, C., Linde, M., Sugiura, Y., Moon, P. K., Majeti, R., Suematsu, M., Mochly-Rosen, D., Weissman, I. L., Longo, F. M., … Andreasson, K. I. (2021). Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature, 1–7. https://doi.org/10.1038/s41586-020-03160-0 Cite
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