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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Inflammation Mediated by Gut Microbiome Alterations Promotes Lung Cancer Development and an Immunosuppressed Tumor Microenvironment
[Cancer Immunology Research] Scientists investigated the role of gut microbiome changes in lung adenocarcinoma development using fecal microbiota transfer and delineated a pathway by which gut microbiome alterations incurred by loss of Lcn2 fostered the proliferation of pro-inflammatory bacteria of the genus Alistipes.
Dual Blockade of IL-10 and PD-1 Leads to Control of SIV Viral Rebound following Analytical Treatment Interruption
[Nature Immunology] Twenty-eight antiretroviral therapy-treated, simian immunodeficiency virus (SIV)mac239-infected rhesus macaques were treated with anti-IL-10, anti-IL-10 plus anti-PD-1, or vehicle.
Convergent Evolution of Monocyte Differentiation in Adult Skin Instructs Langerhans Cell Identity
[Science Immunology] Using ablation of embryo-derived Langerhans cells in the murine adult skin and tracking differentiation of incoming monocyte-derived replacements, researchers found intrinsic intraepidermal heterogeneity.
TCF-1 and TOX Regulate the Memory Formation of Intestinal Group 2 Innate Lymphoid Cells in Asthma
[Nature Communications] Based on house dust mite-induced mice asthma models and human samples, the authors applied flow cytometry, parabiosis, in vivo imaging, and adoptive transplantation to confirm the persistence, migration, and function of CD45+lineage–CD90.2+NK1.1–NKp46–ST2–KLRG1+IL-17RB+ memory-like ILC2s.
Tissue-Specific Inducible IL-33 Expression Elicits Features of Eosinophilic Esophagitis
[Journal of Allergy and Clinical Immunology] Scientists utilized a tetracycline-inducible system to express IL-33 in the esophagus by generating two transgenic mice.
TNFSF14+ Natural Killer Cells Prevent Spontaneous Abortion by Restricting Leucine-Mediated Decidual Stromal Cell Senescence
[EMBO Journal] Investigators performed single-cell RNA transcriptomics on endometrial stromal cells and decidual stromal cells and found that cell senescence during decidualization was accompanied by increased levels of the branched-chain amino acid transporter SLC3A2.
Single-Cell Analysis Identifies Distinct Macrophage Phenotypes Associated with Prodisease and Proresolving Functions in the Endometriotic Niche
[Proceedings of The National Academy of Sciences of The United States of America] Using single-cell RNA-Seq in a mouse model, researchers determined the transcriptomic profiles and functions of different macrophages within endometriosis lesions and in the peritoneal cavity.
cGAS Activation in Classical Dendritic Cells Causes Autoimmunity in TREX1-Deficient Mice
[Proceedings of The National Academy of Sciences of The United States of America] In order to determine the type of cells in which cGAS activation drives autoinflammation, the authors generated conditional cGAS knockout mice on the three prime repair exonuclease 1 (TREX1)-/- background.
Endosialin-Positive CAFs Promote Hepatocellular Carcinoma Progression by Suppressing CD8+ T Cell Infiltration
[Journal for ImmunoTherapy of Cancer] Single-cell sequencing and flow cytometry analysis showed that tumor tissues from endosialin knockout mice had increased CD8+ T cell infiltration.
CD98hc Promotes Drug Resistance in Extranodal Natural Killer/T Cell Lymphoma through Tumor Cell–Derived Small Extracellular Vesicles
[Science Signaling] Scientists showed that high abundance of the transmembrane glycoprotein CD98hc in tumor cells and serum small extracellular vessicles was associated with extranodal natural killer/T cell lymphoma progression and drug resistance.
Hepatic Immune Regulation and Sex Disparities
[Nature Reviews Gastroenterology & Hepatology] Investigators discuss the basic mechanisms of sex disparity in hepatic immune regulation and how these mechanisms influence and modify the development of autoimmune liver diseases, genetic liver diseases, portal hypertension and inflammation in chronic liver disease.
Distinct Mucosal Endotypes as Initiators and Drivers of Rheumatoid Arthritis
[Nature Reviews Rheumatology] The authors argue that mucosal sites and their associated microbial strains can contribute to rheumatoid arthritis evolution via distinct pathogenic mechanisms, which can be considered causal mucosal endotypes.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
