Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

A Stimulus-Contingent Positive Feedback Loop Enables IFN-β Dose-Dependent Activation of Pro-Inflammatory Genes

[Molecular Systems Biology] Investigators showed that a high dose of IFN-β activated an inflammatory gene expression program in contrast to IFN-λ3, a type III IFN, which elicits only the common antiviral gene program.

The Transcriptional Regulator Sin3A Balances IL-17A and Foxp3 Expression in Primary CD4 T Cells

[EMBO Reports] To further investigate the consequences of conditional Sin3A inactivation in more mature precursors and post-thymic T cells, scientists generated CD4-Cre and CD4-CreERT2 Sin3AF/F mice.

Antitumor T-Cell Function Requires CPEB4-Mediated Adaptation to Chronic Endoplasmic Reticulum Stress

[EMBO Journal] Researchers found that, in effector CD8 T lymphocytes, RNA-binding protein CPEB4 constituted a new branch of the unfolded protein response (UPR) that allowed cells to adapt to sustained endoplasmic reticulum stress, yet remained decoupled from the terminal UPR.

Dectin-1 Signaling on Colonic γδ T Cells Promotes Psychosocial Stress Responses

[Nature Immunology] The authors showed that reduction in specific Lactobacillus species, which are involved in T cell differentiation to protect the host immune system, contributed to stress-induced social-avoidance behavior.

Immunoglobulin G-Dependent Inhibition of Inflammatory Bone Remodeling Requires Pattern Recognition Receptor Dectin-1

[Immunity] Scientists studied immunoglobulin G (IgG)-dependent initiation of resolution of inflammation in cytokine- and autoantibody-driven models of rheumatoid arthritis and found pooled serum IgG sialylation inhibited joint inflammation, whereas inhibition of osteoclastogenesis was sialic acid independent.

A Mast Cell–Thermoregulatory Neuron Circuit Axis Regulates Hypothermia in Anaphylaxis

[Science Immunology] Researchers repored that the immunoglobin E/mast cell-mediated drop in body temperature in mice associated with anaphylaxis required the body’s thermoregulatory neural circuit, which was activated when granule-borne chymase from mast cells was deposited on proximal TRPV1+ sensory neurons and stimulated them via protease-activated receptor-1.

Aging Disrupts MANF-Mediated Immune Modulation during Skeletal Muscle Regeneration

[Nature Aging] Investigators uncovered a new mechanism of immune modulation operating during skeletal muscle regeneration that was disrupted in aged animals and relied on the regulation of macrophage function.

Activatable Near-Infrared Probes for the Detection of Specific Populations of Tumor-Infiltrating Leukocytes In Vivo and in Urine

[Nature Biomedical Engineering] The fluorescence of the probes was activated only in the presence of both tumor and leukocyte biomarkers, which allowed for the imaging of populations of specific tumor-infiltrating leukocytes in mouse models of cancers, with sensitivities and specificities similar to those achieved via flow-cytometric analyses of biopsied tumor tissues.

Short Tandem Repeats Are Important Contributors to Silencer Elements in T Cells

[Nucleic Acids Research] CRISPR-mediated genomic deletions validated the repressive function of distinct silencers involved in the repression of non-T cell genes and genes regulated during T cell differentiation.

CCL5-Producing Migratory Dendritic Cells Guide CCR5+ Monocytes into the Draining Lymph Nodes

[Journal of Experimental Medicine] Using two tracking methods, the authors observed that both CD88hiCD26lomonocytes and CD88CD26hi migratory type 1 and type 2 conventional dendritic cells captured inhaled antigens in the lung and migrated to lymph nodes.

The Role of NOD-Like Receptors in Innate Immunity

[Frontiers In Immunology] Scientists review the current knowledge about NOD-like receptors, including the ligands and conditions that stimulate the NLRs and the outcomes of NLR activation in cells and animals. The NLRs play key roles in diverse functions, ranging from transcription of MHC, molecules to initiation of inflammation.

Genetic Conflicts and the Origin of Self/Nonself-Discrimination in the Vertebrate Immune System

[Trends In Immunology] The authors argue that some of the key evolutionary novelties of adaptive immune systems of vertebrates are descendants of prokaryotic toxin–antitoxin systems, and discuss how the emergence of adaptive immunity gave rise to higher order genetic conflicts between genetic parasites and their vertebrate host.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.