Colon Stroma Mediates an Inflammation-Driven Fibroblastic Response Controlling Matrix Remodeling and Healing

Researchers performed single-cell RNA-sequencing of colon-derived stromal cells and identified distinct classes of fibroblasts with gene signatures that were differentially regulated by chronic inflammation, including IL-11–producing inflammatory fibroblasts.
[PLoS Biology]
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Sialic Acid Blockade in Dendritic Cells Enhances CD8+ T Cell Responses by Facilitating High-Avidity Interactions

Scientists established cultures of murine bone marrow-derived dendritic cells that lacked sialic acid expression using a sialic acid-blocking mimetic Ac53FaxNeu5Ac.
[Cellular and Molecular Life Sciences]
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Regulation of Activated T Cell Survival in Rheumatic Autoimmune Diseases

Investigators review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis.
[Nature Reviews Rheumatology]
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Allergy Therapeutics Announces FDA Clearance of IND Application for Novel Peanut Allergy Vaccine Candidate VLP Peanut

Allergy Therapeutics announced that the FDA cleared the group’s Investigational New Drug application (IND) for its novel virus-like particle (VLP)-based peanut allergy vaccine candidate.
[Allergy Therapeutics (GlobeNewswire, Inc.)]
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Mustang Bio Provides an Update on its IND Application for MB-207, a Lentiviral Gene Therapy for Treatment of X-linked Severe Combined Immunodeficiency (“XSCID”) in Previously Transplanted Patients

Mustang Bio, Inc. announced that the FDA has issued a hold, pending Chemistry, Manufacturing and Controls clearance, on the company’s Investigational New Drug application.
[Mustang Bio, Inc.]
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Skin and Heart Allograft Rejection Solely by Long-Lived Alloreactive TRM Cells in Skin of Severe Combined Immunodeficient Mice

By grafting alloskin or heart into severe combined immunodeficient or Rag2KO mice in which a piece of induced CD4+ and/or CD8+ tissue-resident memory (TRM) cell–containing MHC-matched or syngeneic skin was transplanted in advance, scientists addressed this issue.
[Science Advances]
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Defective Humoral Immunity Disrupts Bile Acid Homeostasis Which Promotes Inflammatory Disease of the Small Bowel

Investigators used a CD19−/− mouse model of antibody-deficiency to demonstrate that a relationship exists between dysbiosis, defects in bile acid homeostasis, and gluten-sensitive enteropathy of the small intestine.
[Nature Communications]
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Tissue-Resident Immune Cells in Humans

Scientists propose a five-point checklist for defining resident immune cell types in humans and describe the currently known features of resident immune cells, their mechanisms of development, and their putative functional roles within various human organs.
[Annual Reviews of Immunology]
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Myeloid Cell TBK1 Restricts Inflammatory Responses

The authors showed that TANK-binding kinase 1 (TBK1) served as a vital regulator of proinflammatory macrophage function and protected against tissue inflammation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Tissue-Resident Memory T Cells in the Urogenital Tract

The understanding of T cell memory responses changed drastically with the discovery that specialized T cell memory populations reside within peripheral tissues at key pathogen entry sites.
[Nature Reviews Nephrology]
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M-CSF Supports Medullary Erythropoiesis and Erythroid Iron Demand Following Burn Injury through Its Activity on Homeostatic Iron Recycling

The authors found M-CSF secretion was increased in burn patients and a murine model of post burn ACI, so they neutralized M-CSF in ACI mice to determine if erythropoiesis was improved.
[Scientific Reports]
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