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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
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Leukemia Escapes Immunity by Imposing a Type 1 Regulatory Program on Neoantigen-Specific CD4+ T Cells
[Blood] Using clinical a novel mouse model, researchers showed that neoantigen-specific CD4+ T cells are induced to adopt type 1 regulatory (Tr1) function in the leukemia microenvironment.
Prostaglandin E-EP2/EP4 Signaling Induces the Tumor-Infiltrating Treg Phenotype for Tumor Growth
[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that prostaglandin E2 (PGE2) produced in tumor microenvironment directly acts on its receptor EP2/EP4 on Tregs to induce the tumor-infiltrating Treg phenotype.
Immunomodulation of UVB-Induced Regulatory T Cells Prevents the Establishment of Squamous Cell Carcinoma
[Journal for Immunotherapy of Cancer] Scientists showed that the manipulation of ultraviolet-induced regulatory T cells prevents early cutaneous squamous cell carcinoma establishment.
A “Function-First” Approach to Identify Regulatory T Cell-Targeting Antibodies for Immunotherapy
[Cancer Immunology Research] To generate antibodies specific for tumor-associated Tregs, lymphocytes were isolated from tumor-bearing mice and panned against the n-CoDeR phage antibody library.
Pyroptosis Modulates Multiple Immune Cell Populations in Targeted Therapy-Treated Melanoma
[Cancer Immunology Research] Using single-cell RNA-sequencing and flow cytometry in BRAFi + MEKi treated melanoma, researchers showed herein that isogenic Gsdme knockout tumors show decreased infiltration with T cells, natural killer cells, and regulatory T cells compared to control tumors.
The Frequency of Regulatory T-Cells in Hashimoto’s Thyroiditis and Graves’ Disease
[Clinical and Experimental Medicine] Investigators compared the number of CD4/CD25/FOXP3 T regulatory cells in the different forms of autoimmune thyroid diseases and in the normal population.
Cellular Immune Endophenotypes Separating Early and Late-Onset Myasthenia Gravis
[JCI Insight] Analyzing two independent cohorts,researchers identified distinct immunological differences driven by three main lymphocyte populations. Lower frequencies of mucosa-associated invariant T cells and naïve CD8 T cells were observed in late-onset myasthenia, suggesting enhanced immune senescence.
Caspase-3 Deficiency Inhibits the Development and Anti-Tumor Response of Bone Marrow-Derived Dendritic Cells
[Discover Oncology] Scientists investigated the impact of Caspase-3 gene deletion on bone marrow-derived dendritic cells (BMDCs) and their anti-tumor functions. BMDCs were generated in vitro using GM-CSF and IL-4 from Caspase-3 knockout and heterozygous mouse progenitors.
Macrophage-Derived Exosomes in Autoimmune Diseases: Mechanistic Insights and Therapeutic Implications
[Immunologic Research] The authors compile current evidence regarding the involvement of macrophage-derived exosomes in autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus, emphasizing their potential as both biomarkers and therapeutic agents.
Imfinzi Approved in the US As First and Only Perioperative Immunotherapy for Patients with Early Gastric and Gastroesophageal Cancers
[Astrazeneca] AstraZeneca’s Imfinzi in combination with standard-of-care fluorouracil, leucovorin, oxaliplatin, and docetaxel chemotherapy has been approved in the US for the treatment of adult patients with resectable, early-stage and locally advanced gastric and gastroesophageal junction cancers.
Lysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation
[Nature Communications] Scientists demonstrated that lysosomal acidity and cathepsin L activity in eosinophils are elevated in asthmatic patients and mouse models.
Antigen-Specific B Cell Response Regulation by IL-10-Producing Tolerogenic Dendritic Cells
[Science Advances] Researchers showed that IL-10–producing tolerogenic dendritic cells regulate B cell responses through direct and indirect mechanisms.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
