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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
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SAICAR Drives T Regulatory Cell Differentiation and FOXP3 Maintenance to Promote Immunotherapy Resistance
[Cancer Research] Scientists identified the purine biosynthesis intermediate succinylaminoimidazole carboxamide ribose-5′-phosphate (SAICAR) as a key metabolic driver of Treg induction and resistance to anti–PD-1 immunotherapy.
The Long Noncoding RNA Lnc13 Restrains Inflammatory Responses to Maintain Oral Tolerance to Gluten
[Nature Immunology] In HLA-DQ8 transgenic mice lacking lnc13, unmanipulated gluten ingestion led to molecular signatures resembling human celiac disease and hallmark features of loss of oral tolerance to gluten: increased IFN-γ+ lymphocytes, IL-12+ myeloid cells, cytotoxic intraepithelial immune cells, and crypt hyperplasia in the small intestine.
Foxp3 Drives Context-Dependent Epigenetic Programs That Define Regulatory T Cell Molecular Identity and Function
[Science Immunology] Leveraging Foxp3-transduced conventional T cells as a gain-of-function probe in mice, researchers identified a previously unrecognized subset that acquires endogenous Foxp3 expression, Treg cell–like transcriptomic and chromatin features, and suppressive functions exclusively in vivo.
Impaired Suppressive Effect of FoxP3 Regulatory T Cells on B Cells in Multiple Sclerosis
[Journal of Neuroinflammation] Researchers demonstrated that Tregs exert a robust suppressive effect on B cell proliferation, IL-6 secretion, and NFATc1 which is [1] independent of Ca2+ signaling [2], dependent on direct cell contact, and [3] impaired in multiple sclerosis.
Cellenkos Announces FDA Clearance of Investigational New Drug (IND) Application for Phase Ib/IIa Trial of CK0802 in Steroid-Refractory Graft-versus-Host Disease (GVHD)
[Cellenkos®, Inc. (BioSpace)] Cellenkos®, Inc. announced that the US FDA has cleared its Investigational New Drug application to initiate a Phase 1b/ 2a clinical trial of CK0802 for the treatment of patients with steroid-refractory GVHD.
Merck KGaA, Darmstadt, Germany, Initiates Phase III Study for Enpatoran in Lupus with Active Skin Manifestations
[Merck KGaA] Merck KGaA announced that the first trial participant has been dosed in its Phase III ELOWEN study evaluating enpatoran, an investigational oral therapy for people living with lupus who experience active skin manifestations.
Tissue-Specific Tolerance Mechanisms and Lymph Node Co-Drainage Shape T Cell Immunity in the Upper Digestive System and Pancreatic Cancer Progression
[Cell Reports] High-dose hepatic-secreted OVA triggered antigen-specific T cell deletion, whereas secreted pancreatic and intestinal OVA induced Tregs, revealing immunological ignorance, clonal deletion, and Treg cell generation as tissue-specific tolerance mechanisms.
Costimulation Loss Enhances IL-2-Driven Treg Generation by PI3K-STAT3 Inhibition in CNS Autoimmunity
[EMBO Molecular Medicine] Scientists demonstrated that costimulation blockade paradoxically potentiates IL-2-driven Treg generation by selectively reprogramming intracellular cytokine signaling.
TLR1 Deficiency Associates with Immune Dysregulation and Colitis
[Proceedings of the National Academy of Sciences of the United States of America] Researchers identified a homozygous truncating Toll-like receptor 1 (TLR1) variant associated with immune dysregulation and colitis. The administration of IL-10 significantly alleviated the colitis phenotype associated with TLR1 deficiency in mice.
Loss of the Autoimmune Risk Gene TREX1 Reveals a Convergence of Mechanisms Promoting Immune Tolerance Loss and Antitumor Immunity
[Science Advances] Researchers showed that ablation of the cytosolic DNA exonuclease TREX1 predisposes mice to autoimmunity while promoting robust antitumor immunity. Constitutive TREX1 loss leads to early onset autoimmunity, characterized by multiorgan CD8+ T cell infiltration, myocarditis, and Sjögren’s syndrome–like disease.
Metabolic Adaptations of Immunosuppressive Cells in Cancer: Mechanisms and Therapeutic Targets
[Experimental & Molecular Medicine] Scientists delineate the immunosuppressive cell types within the tumor microenvironment, their key metabolic adaptations and the mechanisms by which they suppress antitumor immunity.
JMJD1C-Mediated Epigenetic Control of Autoimmunity and HIT Antibody Production
[Blood] While JMJD1C was expressed throughout B cell development and was dispensable for normal B-cell development, its deficiency disrupts immune tolerance and promots production of self-reactive antibodies in systemic autoimmune diseases.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
