Category Archives: Immune Regulation

Immune Regulation News is an online publicaiton and email newsletter covering research into the regulation, suppression, and modulation of the immune system.
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For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

Ssu72 Is a T-cell Receptor-Responsive Modifier That Is Indispensable for Regulatory T Cells

The authors found that the Ssu72 phosphatase was activated by various T-cell receptor signaling pathways, including the T-cell receptor and IL-2R pathways, and localized at the cell membrane.
[Cellular & Molecular Immunology]
Lee, J.-K., Koo, S.-Y., Nam, H.-M., Lee, J.-B., Ko, J., Kim, K.-M., Park, E.-J., Kim, T. J., Lee, H., Go, H., & Lee, C.-W. (2021). Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells. Cellular & Molecular Immunology, 1–17. https://doi.org/10.1038/s41423-021-00671-2 Cite
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UTX Promotes CD8+ T Cell-Mediated Antiviral Defenses but Reduces T Cell Durability

Investigators showed that T cell receptor-stimulated CD8+ T cells increased their expression of ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) to enhance gene expression.
[Cell Reports]
Mitchell, J. E., Lund, M. M., Starmer, J., Ge, K., Magnuson, T., Shpargel, K. B., & Whitmire, J. K. (2021). UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability. Cell Reports, 35(2). https://doi.org/10.1016/j.celrep.2021.108966 Cite
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Interleukin-17D Regulates Group 3 Innate Lymphoid Cell Function through Its Receptor CD93

Researchers examined the role of IL-17D, a poorly understood member in the IL-17 family. Il17d−/− mice were more susceptible to acute colitis, bacterial infection and experimentally induced colon cancer than their wildtype counterparts.
[Immunity]
Huang, J., Lee, H., Zhao, X., Han, J., Su, Y., Sun, Q., Shao, J., Ge, J., Zhao, Y., Bai, X., He, Y., Wang, X., Wang, X., & Dong, C. (2021). Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93. Immunity, 54(4), 673-686.e4. https://doi.org/10.1016/j.immuni.2021.03.018 Cite
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Deconvoluting Global Cytokine Signaling Networks in Natural Killer Cells

The authors employed a multi-omics approach to deconstruct and rebuild the complex interaction of multiple cytokine signaling pathways in NK cells.
[Nature Immunology]
Wiedemann, G. M., Santosa, E. K., Grassmann, S., Sheppard, S., Le Luduec, J.-B., Adams, N. M., Dang, C., Hsu, K. C., Sun, J. C., & Lau, C. M. (2021). Deconvoluting global cytokine signaling networks in natural killer cells. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-021-00909-1 Cite
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Accumulation of Cytotoxic T Cells in the Aged CNS Leads to Axon Degeneration and Contributes to Cognitive and Motor Decline

Investigators examined the role of cytotoxic CD8+ T lymphocytes, a type of adaptive immune cells previously identified as amplifiers of axonal perturbation in various models of genetically mediated CNS diseases
[Nature Aging]
Groh, J., Knöpper, K., Arampatzi, P., Yuan, X., Lößlein, L., Saliba, A.-E., Kastenmüller, W., & Martini, R. (2021). Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline. Nature Aging, 1–11. https://doi.org/10.1038/s43587-021-00049-z Cite
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TIM4 Expression by Dendritic Cells Mediates Uptake of Tumor-Associated Antigens and Anti-tumor Responses

The authors showed that capture and engulfment of cell associated antigens by tissue resident lung cDC1 was inhibited during progression of mouse lung tumors.
[Nature Communications]
Caronni, N., Piperno, G. M., Simoncello, F., Romano, O., Vodret, S., Yanagihashi, Y., Dress, R., Dutertre, C.-A., Bugatti, M., Bourdeley, P., Del Prete, A., Schioppa, T., Mazza, E. M. C., Collavin, L., Zacchigna, S., Ostuni, R., Guermonprez, P., Vermi, W., Ginhoux, F., … Benvenuti, F. (2021). TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses. Nature Communications, 12(1), 2237. https://doi.org/10.1038/s41467-021-22535-z Cite
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Rescue of Maternal Immune Activation-Induced Behavioral Abnormalities in Adult Mouse Offspring by Pathogen-Activated Maternal Treg Cells

Scientists showed that adoptive transfer of regulatory T (Treg) cells largely reversed maternal immune activation-induced phenotypes.
[Nature Neuroscience]
Xu, Z., Zhang, X., Chang, H., Kong, Y., Ni, Y., Liu, R., Zhang, X., Hu, Y., Yang, Z., Hou, M., Mao, R., Liu, W.-T., Du, Y., Yu, S., Wang, Z., Ji, M., & Zhou, Z. (2021). Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal T reg cells. Nature Neuroscience, 1–13. https://doi.org/10.1038/s41593-021-00837-1 Cite
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Cell Barrier Function of Resident Peritoneal Macrophages in Post-Operative Adhesions

The authors showed that resident F4/80HighCD206− peritoneal macrophages promptly accumulate on the lesion and form a ‘macrophage barrier’ to shield fibrin clots in place of the lost mesothelium in mice.
[Nature Communications]
Ito, T., Shintani, Y., Fields, L., Shiraishi, M., Podaru, M.-N., Kainuma, S., Yamashita, K., Kobayashi, K., Perretti, M., Lewis-McDougall, F., & Suzuki, K. (2021). Cell barrier function of resident peritoneal macrophages in post-operative adhesions. Nature Communications, 12(1), 2232. https://doi.org/10.1038/s41467-021-22536-y Cite
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A Guide to Interrogating Immunometabolism

Investigators provide a framework for navigating and selecting the appropriate biochemical techniques to explore immunometabolism.
[Nature Reviews Immunology]
Voss, K., Hong, H. S., Bader, J. E., Sugiura, A., Lyssiotis, C. A., & Rathmell, J. C. (2021). A guide to interrogating immunometabolism. Nature Reviews Immunology, 1–16. https://doi.org/10.1038/s41577-021-00529-8 Cite
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Directed Differentiation of Human Induced Pluripotent Stem Cells to Hepatic Stellate Cells

Researchers describe a protocol to differentiate human induced pluripotent stem cells into hepatic stellate cells.
[Nature Protocols]
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Inflammatory Processes in the Liver: Divergent Roles in Homeostasis and Pathology

Scientists review the dynamic roles of inflammatory mediators in responses to sterile injury in the context of homeostasis and disease, the clinical implications of dysregulated hepatic immune activity and therapeutic developments to regulate liver-specific immunity.
[Cellular & Molecular Immunology]
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