Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Organoids as a Tool to Study Homeostatic and Pathological Immune–Epithelial Interactions in the Gut

[Clinical & Experimental Immunology] Researchers provided an overview of how intestinal organoids are being co-cultured with immune cells leading to substantial advances in our understanding of immune–epithelial interactions in the gut.

Spatial Distribution of Tumor-Associated Macrophages in an Orthotopic Prostate Cancer Mouse Model

[Pathology and Oncology Research] Researchers examined the spatial-temporal dynamics of three different immune cell types infiltrating tumors using QuPath image analysis software. Immunohistochemistry staining revealed that F4/80+ tumor-associated macrophages were the most abundant immune cells in all groups, irrespective of time or treatment.

Respiratory Complex I Regulates Dendritic Cell Maturation in Explant Model of Human Tumor Immune Microenvironment

[Journal For Immunotherapy Of Cancer] Scientists established a patient-derived explant culture model of breast cancer, which retained the immune contexture of the primary tumor, recapitulating cytokine profiles and CD8+ T cell cytotoxic activity.

Surface-Functionalized Microgels as Artificial Antigen-Presenting Cells to Regulate Expansion of T Cells

[Advanced Materials] Investigators showed that microgels with tailored surface biochemical properties can serve as aAPCs to mediate T cell activation and expansion.

Blockade of TGF-β and PD-L1 by Bintrafusp Alfa Promotes Survival in Preclinical Ovarian Cancer Models by Promoting T Effector and NK Cell Responses

[British Journal Of Cancer] The authors tested whether coordinated blockade of TGF-β and PD-L1 with bintrafusp alfa could provoke anti-tumour immune responses in preclinical high-grade serous ovarian cancer models.

CCR5 and Inflammatory Storm

[Ageing Research Reviews] Scientists illuminate the regulatory axes modulating signaling pathways in inflammatory cells by providing a comprehensive overview of the pathogenic processes associated with CCR5 and its ligands across various disorders.

Long COVID Linked to Signs of Ongoing Inflammatory Responses in Blood

[New Scientist] People with long-COVID after a serious COVID-19 infection have raised levels of many immune molecules in their blood. Better understanding how these molecules can vary could lead to more targeted treatments

Evolution of T Cells in the Cancer-Resistant Naked Mole-Rat

[Nature Communications] Using single-cell transcriptomics, researchers found that that naked mole rats had a large circulating population of γδT cells, which in mice and humans mostly reside in peripheral tissues and induce anti-cancer cytotoxicity.

OTUD5 Promotes the Inflammatory Immune Response by Enhancing MyD88 Oligomerization and Myddosome Formation

[Cell Death & Differentiation] Researchers identified OTUD5 acted as an essential regulator for MyD88 oligomerization and Myddosome formation. OTUD5 directly interacted with MyD88 and cleaved its K11-linked polyubiquitin chains at Lys95, Lys231 and Lys250.

TL1A Is an Epithelial Alarmin That Cooperates with IL-33 for Initiation of Allergic Airway Inflammation

[Journal Of Experimental Medicine] Investigators demonstrated that TNF-like ligand 1A was an epithelial alarmin, constitutively expressed in alveolar epithelium at steady state in both mice and humans, which cooperates with IL-33 for early induction of IL-9high ILC2s during the initiation of allergic airway inflammation.

Joint-Specific Memory, Resident Memory T Cells and the Rolling Window of Opportunity in Arthritis

[Nature Reviews Rheumatology] In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis, the immune system targets certain joints but not others. The pattern of joints affected varies by disease and by individual, with flares most commonly involving joints that were previously inflamed.

Novel T Cell Exhaustion Gene Signature to Predict Prognosis and Immunotherapy Response in Thyroid Carcinoma From Integrated RNA-Sequencing Analysis

[Scientific Reports] The authors constructed an eight-gene prognostic signature, and developed a risk score named the exhaustion-related gene score to forecast both prognosis and immunotherapy response in thyroid carcinoma.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.