Transcriptomic Analyses of Gastrulation-Stage Mouse Embryos with Differential Susceptibility to Alcohol

Scientists profiled gene expression in gastrulation-stage embryos from two commonly used, genetically similar mouse substrains, C57BL/6J and C57BL/6NHsd, that differed in alcohol sensitivity.
[Disease Models & Mechanisms]
Boschen, K. E., Ptacek, T. S., Berginski, M. E., Simon, J. M., & Parnell, S. E. (2021). Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol. Disease Models & Mechanisms, 14(6). https://doi.org/10.1242/dmm.049012 Cite
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Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis

The authors showed that CD4+ T cells from patients with psoriasis and psoriatic arthritis exhibit increased production of IL-17 but decreased expression of IL-2 and PD-1.
[Journal of Immunology]
Hofmann, S. R., Carlsson, E., Kapplusch, F., Carvalho, A. L., Liloglou, T., Schulze, F., Abraham, S., Northey, S., Russ, S., Surace, A. E. A., Yoshida, N., Tsokos, G. C., & Hedrich, C. M. (2021). Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2100240 Cite
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pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis

Researchers performed a phenome-wide association study and reported that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduced GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously reported.
[Journal of Immunology]
Xie, L., McKenzie, C. I., Qu, X., Mu, Y., Wang, Q., Bing, N., Naidoo, K., Alam, M. J., Yu, D., Gong, F., Ang, C., Robert, R., Marques, F. Z., Furlotte, N., Hinds, D., Gasser, O., Team, 23andMe Research, Xavier, R. J., & Mackay, C. R. (2021). pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2001363 Cite
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m6A Demethylase ALKBH5 Controls CD4+ T Cell Pathogenicity and Promotes Autoimmunity

Investigators reported that m6A eraser AlkB homolog 5, but not FTO, maintained the ability of naïve CD4+ T cells to induce adoptive transfer colitis.
[Science Advances]
Zhou, J., Zhang, X., Hu, J., Qu, R., Yu, Z., Xu, H., Chen, H., Yan, L., Ding, C., Zou, Q., Ye, Y., Wang, Z., Flavell, R. A., & Li, H.-B. (2021). m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity. Science Advances, 7(25), eabg0470. https://doi.org/10.1126/sciadv.abg0470 Cite
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Mechanisms Underlying Divergent Responses of Genetically Distinct Macrophages to IL-4

The authors evaluated effects of >50 million single-nucleotide polymorphisms and short insertions/deletions provided by five inbred strains of mice on the responses of macrophages to interleukin-4 (IL-4), a cytokine that plays pleiotropic roles in immunity and tissue homeostasis.
[Science Advances]
Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4 | Science Advances. (n.d.). Retrieved June 18, 2021, from https://advances.sciencemag.org/content/7/25/eabf9808 Cite
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PolyTLR7/8a-Conjugated, Antigen-Trapping Gold Nanorods Elicit Anticancer Immunity against Abscopal Tumors by Photothermal Therapy-Induced In Situ Vaccination

Scientists demonstrated that PTT-induced in situ vaccination cancer therapy can elicit potent antitumor immunity against disseminated and metastatic tumors.
[Biomaterials]
Liu, X., Su, Q., Song, H., Shi, X., Zhang, Y., Zhang, C., Huang, P., Dong, A., Kong, D., & Wang, W. (2021). PolyTLR7/8a-conjugated, antigen-trapping gold nanorods elicit anticancer immunity against abscopal tumors by photothermal therapy-induced in situ vaccination. Biomaterials, 275, 120921. https://doi.org/10.1016/j.biomaterials.2021.120921 Cite
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FibroGen and HiFiBiO Announce Transformative Partnership to Advance Next-Generation Therapies for Patients with Cancer and Autoimmune Disease

FibroGen, Inc. and HiFiBiO Therapeutics, a private, multinational clinical-stage biotherapeutics company with expertise in immune modulation and single cell science announced a partnership covering three HiFiBiO programs.
[FibroGen, Inc.]
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Kytopen Awarded NIH Grant of Up to $2M to Unlock the Power of Engineered Natural Killer (NK) Cells via Flowfect® Platform

Kytopen announced it was awarded a SBIR Fast Track grant from the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institute of Health. Kytopen is eligible for up to $2M over the course of the three-year award as project milestones are successfully completed within the Phase I and Phase II portions of the grant.
[Kytopen]
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Improving Antitumor Immunity Using Antiangiogenic Agents: Mechanistic Insights, Current Progress, and Clinical Challenges

The authors discuss synergies between antiangiogenic agents and cancer immunotherapy based on results from preclinical and translational studies.
[Cancer Communications]
Li, S.-J., Chen, J.-X., & Sun, Z.-J. (n.d.). Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges. Cancer Communications, n/a(n/a). https://doi.org/10.1002/cac2.12183 Cite
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Revisiting Steroidogenesis and Its Role in Immune Regulation with the Advanced Tools and Technologies

Investigators review the role of steroidogenesis in regulating inflammation and immunity, discuss the unresolved questions, and how this area can bring another golden age of steroid hormone research with the development of new tools and technologies and advancement of the scientific methods.
[Genes & Immunity]
Chakraborty, S., Pramanik, J., & Mahata, B. (2021). Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies. Genes & Immunity, 1–16. https://doi.org/10.1038/s41435-021-00139-3 Cite
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Enhanced Anti-Tumor Response Elicited by a Novel Oncolytic HSV-1 Engineered with an Anti-PD-1 Antibody

Scientists generated a recombinant herpes simplex virus type 1 (HSV-1), HSV-aPD-1, carrying a full-length humanized anti-PD-1 monoclonal antibody that replicated and expressed anti-PD-1 mAbs in tumor cells in vitro and in vivo.
[Cancer Letters]
Tian, C., Liu, J., Zhou, H., Li, J., Sun, C., Zhu, W., Yin, Y., & Li, X. (2021). Enhanced anti-tumor response elicited by a novel oncolytic HSV-1 engineered with an anti-PD-1 antibody. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.06.005 Cite
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