The authors found that the Ssu72 phosphatase was activated by various T-cell receptor signaling pathways, including the T-cell receptor and IL-2R pathways, and localized at the cell membrane.
[Cellular & Molecular Immunology]
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Lee, J.-K., Koo, S.-Y., Nam, H.-M., Lee, J.-B., Ko, J., Kim, K.-M., Park, E.-J., Kim, T. J., Lee, H., Go, H., & Lee, C.-W. (2021). Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells. Cellular & Molecular Immunology, 1–17. https://doi.org/10.1038/s41423-021-00671-2 Cite
Investigators showed that T cell receptor-stimulated CD8+ T cells increased their expression of ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) to enhance gene expression.
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Researchers examined the role of IL-17D, a poorly understood member in the IL-17 family. Il17d−/− mice were more susceptible to acute colitis, bacterial infection and experimentally induced colon cancer than their wildtype counterparts.
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Huang, J., Lee, H., Zhao, X., Han, J., Su, Y., Sun, Q., Shao, J., Ge, J., Zhao, Y., Bai, X., He, Y., Wang, X., Wang, X., & Dong, C. (2021). Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93. Immunity, 54(4), 673-686.e4. https://doi.org/10.1016/j.immuni.2021.03.018 Cite
The authors employed a multi-omics approach to deconstruct and rebuild the complex interaction of multiple cytokine signaling pathways in NK cells.
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Investigators examined the role of cytotoxic CD8+ T lymphocytes, a type of adaptive immune cells previously identified as amplifiers of axonal perturbation in various models of genetically mediated CNS diseases
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Groh, J., Knöpper, K., Arampatzi, P., Yuan, X., Lößlein, L., Saliba, A.-E., Kastenmüller, W., & Martini, R. (2021). Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline. Nature Aging, 1–11. https://doi.org/10.1038/s43587-021-00049-z Cite
The authors showed that capture and engulfment of cell associated antigens by tissue resident lung cDC1 was inhibited during progression of mouse lung tumors.
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Caronni, N., Piperno, G. M., Simoncello, F., Romano, O., Vodret, S., Yanagihashi, Y., Dress, R., Dutertre, C.-A., Bugatti, M., Bourdeley, P., Del Prete, A., Schioppa, T., Mazza, E. M. C., Collavin, L., Zacchigna, S., Ostuni, R., Guermonprez, P., Vermi, W., Ginhoux, F., … Benvenuti, F. (2021). TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses. Nature Communications, 12(1), 2237. https://doi.org/10.1038/s41467-021-22535-z Cite
Scientists showed that adoptive transfer of regulatory T (Treg) cells largely reversed maternal immune activation-induced phenotypes.
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Xu, Z., Zhang, X., Chang, H., Kong, Y., Ni, Y., Liu, R., Zhang, X., Hu, Y., Yang, Z., Hou, M., Mao, R., Liu, W.-T., Du, Y., Yu, S., Wang, Z., Ji, M., & Zhou, Z. (2021). Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal T reg cells. Nature Neuroscience, 1–13. https://doi.org/10.1038/s41593-021-00837-1 Cite
The authors showed that resident F4/80HighCD206− peritoneal macrophages promptly accumulate on the lesion and form a ‘macrophage barrier’ to shield fibrin clots in place of the lost mesothelium in mice.
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Ito, T., Shintani, Y., Fields, L., Shiraishi, M., Podaru, M.-N., Kainuma, S., Yamashita, K., Kobayashi, K., Perretti, M., Lewis-McDougall, F., & Suzuki, K. (2021). Cell barrier function of resident peritoneal macrophages in post-operative adhesions. Nature Communications, 12(1), 2232. https://doi.org/10.1038/s41467-021-22536-y Cite
Investigators provide a framework for navigating and selecting the appropriate biochemical techniques to explore immunometabolism.
[Nature Reviews Immunology]
Researchers describe a protocol to differentiate human induced pluripotent stem cells into hepatic stellate cells.
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Scientists review the dynamic roles of inflammatory mediators in responses to sterile injury in the context of homeostasis and disease, the clinical implications of dysregulated hepatic immune activity and therapeutic developments to regulate liver-specific immunity.
[Cellular & Molecular Immunology]
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