Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Spermine Enhances Antiviral and Anticancer Responses by Stabilizing DNA Binding with the DNA Sensor cGAS

[Immunity] Scientists investigated how indiscriminate DNA sensors, such as cyclic GMP-AMP synthase (cGAS), made the self-nonself distinction.

Persistent Virus-Specific and Clonally Expanded Antibody-Secreting Cells Respond to Induced Self-antigen in the CNS

[Acta Neuropathologica] The authors profiled B cells from the central nervous system (CNS) of murine models of intracranial viral infections and autoimmunity, and identified a population of clonally expanded, antibody-secreting cells that had undergone class-switch recombination and extensive somatic hypermutation following intracranial infection with attenuated lymphocytic choriomeningitis virus.

Targeted Modulation of Immune Cells and Tissues Using Engineered Biomaterials

[Nature Reviews Bioengineering] Scientists review recent advances in biomaterials-based strategies, focusing on targeting of lymphoid tissues, circulating leukocytes, tissue-resident immune cells and immune cells at disease sites.

Targeting Protein Phosphatases in Cancer Immunotherapy and Autoimmune Disorders

[Nature Reviews Drug Discovery] The authors discuss recent progress in phosphatase drug discovery, with emphasis on the development of selective modulators that exhibit biological activity. The roles and regulation of protein phosphatases in immune cells and their potential as powerful targets for immuno-oncology and autoimmunity indications are assessed.

Galectin-7 Reprograms Skin Carcinogenesis by Fostering Innate Immune Evasive Programs

[Cell Death & Differentiation] Researchers demonstrated a critical role for galectin-7, a β-galactoside-binding protein preferentially expressed in skin tissue, during non-melanoma skin cancerdevelopment.

Graft-versus-Host Disease Is Locally Maintained in Target Tissues by Resident Progenitor-Like T Cells

[Immunity] Researchers showed, using multiple approaches including parabiosis of mice with graft-versus-host disease (GVHD), that GVHD was primarily maintained locally within diseased tissues.

BET Inhibitors Rescue Anti-PD1 Resistance by Enhancing TCF7 Accessibility in Leukemia-Derived Terminally Exhausted CD8+ T Cells

[Leukemia] Ex vivo treatment of cells from acute myeloid leukemia (AML) mice and AML patients with bromodomain and extra-terminal domain (BET) inhibitors reversed CD8+ T cell exhaustion by restoring proliferative capacity and expansion of the more functional precursor-exhausted T cells.

IFNγ Signaling in Cytotoxic T Cells Restricts Anti-tumor Responses by Inhibiting the Maintenance and Diversity of Intra-Tumoral Stem-Like T Cells

[Nature Communications] The authors reported that specific deletion of IFNγR in CD8 T cells promoted tumor control in a mouse model of melanoma, and provide evidence of a negative feedback loop whereby IFNγ depletes stem-like T cells to restrict anti-tumor immunity.

YTHDF2 Orchestrates Tumor-Associated Macrophage Reprogramming and Controls Antitumor Immunity through CD8+ T Cells

[Nature Immunology] Selectively targeting YTHDF2 in tumor-associated macrophages (TAMs) using a Toll-like receptor 9 agonist-conjugated small interfering RNA reprogrammed TAMs toward an antitumoral phenotype, restrained tumor growth, and enhanced the efficacy of PD-L1 antibody therapy.

Blocking Common γ Chain Cytokine Signaling Ameliorates T Cell–Mediated Pathogenesis in Disease Models

[Science Translational Medicine] Scientists reported that a xenogeneic graft-versus-host disease (GVHD) mouse model recapitulated hallmarks of acute and chronic GVHD, with T cell expansion/infiltration into tissues and liver fibrosis, as well as hallmarks of immune aplastic anemia, with bone marrow aplasia and peripheral cytopenia.

An Evolved AAV Variant Enables Efficient Genetic Engineering of Murine T Cells

[Cell] To enable targeted knockins in murine T cells, we evolved Ark313, a synthetic adeno-associated virus (AAV) that exhibited high transduction efficiency in murine T cells. They performed a genome-wide knockout screen and identified QA2 as an essential factor for Ark313 infection.

NET Formation Is Independent of Gasdermin D and Pyroptotic Cell Death

[Science Signaling] Through experiments with known physiological activators of neutrophil extracellular traps (NET) formation and ligands that activated canonical and noncanonical inflammasome signaling pathways, the authors demonstrated that Gsdmd-deficient mouse neutrophils were as competent as wild-type mouse neutrophils in producing NETs.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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