Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Neutrophil Extracellular Traps Are Involved in Enhanced Contact Hypersensitivity Response in IL-36 Receptor Antagonist-Deficient Mice

[Scientific Reports] The authors examined the contact hypersensitivity (CHS) response and NET formation in Il36rn−/− mice. Il36rn−/− mice showed enhanced CHS responses, increased infiltration of inflammatory cells, including neutrophils, CD4+ T cells, and CD8+ T cells.

Assessment of DNA Methylation in Porcine Immune Cells Reveals Novel Regulatory Elements Associated with Cell-Specific Gene Expression and Immune Capacity Traits

[BMC Genomics] Scientists performed whole-genome bisulfite sequencing to assess DNA methylation patterns in nine pig immune cell populations: CD21+ and CD21− B cells, four T cell fractions, natural killer and myeloid cells, and neutrophils.

CDCP1 Regulates Retinal Pigmented Epithelial Barrier Integrity for the Development of Experimental Autoimmune Uveitis

[JCI Insight] The authors found that CDCP1 was present on both human and mouse retinal pigmented epithelial cells, a component of the blood-retina barrier, using a new anti-CDCP1 monoclonal antibody that they developed.

CD20+ T Cells: An Emerging T Cell Subset in Human Pathology

[Inflammation Research] Investigators summarises the latest understanding of CD20+ T cells, their presence in various diseases, their putative function and how they may be an ongoing target of CD20-depleting agents.

Elevated Apoptosis and Abnormal Apoptosis Signaling of Regulatory T Cells in Patients with Systemic Lupus Erythematosus

[Lupus] Scientists investigated the apoptosis rate of Tregs and their suppressive activity in patients with SLE and then to recognize the genes and signaling pathways that cause Treg apoptosis.

Myc Inhibition Tips the Immune Balance to Promote Antitumor Immunity

[Cellular & Molecular Immunology] Researchers showed that the adaptive immune system played a vital role in the antitumor effect of pharmacologic inhibition of Myc.

lncRNA-GM Targets Foxo1 to Promote T Cell–Mediated Autoimmunity

[Science Advances] The authors reported that lncRNA-GM polarizes T helper 17 differentiation but inhibits iTreg differentiation by reducing activity of Foxo1, a transcriptional factor that is important in inhibiting TH17 differentiation but promoting Treg generation.

Tumor Microenvironmental Signals Reshape Chromatin Landscapes to Limit the Functional Potential of Exhausted T Cells

[Science Immunology] Investigators found that terminally exhausted T cells had unexpected chromatin features that limit their transcriptional potential.

Cis Interactions between CD2 and Its Ligands on T Cells Are Required for T Cell Activation

[Science Immunology] By generating new knockout mouse strains lacking CD2 or CD48 in the C57BL/6 background, scientists determined that whereas CD2 was necessary on T cells for T cell activation, its ligand CD48 was not required on antigen-presenting cells.

Profiling of Epigenetic Marker Regions in Murine ILCs under Homeostatic and Inflammatory Conditions

[Journal of Experimental Medicine] Marker regions were located in genes with a described function for innate lymphoid cells (ILCs) , such as Tbx21, Gata3, or Il23r, but also in genes that have not been related to ILC biology.

Primate Research Center Head Will Keep Job despite Misconduct, Provoking Shock and Dismay

[ScienceInsider] A decision by the Southwest National Primate Research Center to retain its director with full duties despite a finding that he engaged in research misconduct has sparked disbelief.

Regulatory T Cells in Skeletal Muscle Repair and Regeneration: Recent Insights

[Cell Death & Disease] Tregsregulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.