Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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Cellenkos Receives FDA Fast Track Designation for CK0803 in Amyotrophic Lateral Sclerosis (ALS)

August 28, 2026

[Cellenkos, Inc. (PR Newswire)] Cellenkos, Inc. announced that the US FDA has granted Fast Track designation to CK0803 for the treatment of Amyotrophic Lateral Sclerosis (ALS). CK0803 is an investigational, allogeneic, cord blood-derived Treg cell therapy engineered to express high levels of CXCR3 and CD11a.

T Cell Fate Is Dictated by Different Antigen-Presenting Cells in Response to Dietary Versus Gut Epithelial Self-Antigen

August 28, 2026

[Immunity] Researchers compared ovalbumin (OVA)-specific T cell fates using mice fed OVA, or expressing secreted, cytosolic (c), or transmembrane epithelial OVA. BATF3+ antigen-presenting cells were indispensable for CD4+ T cell proliferation only in cOVA mice, yet they drove Treg cell differentiation across all epithelial OVA models.

CD137 Agonists in Mice Suppress Germinal Center Responses by Increasing the Immunosuppressive Activity of Follicular Regulatory T-Cells

August 28, 2026

[EMBO Journal] Investigators showed that agonistic anti-CD137 monoclonal antibodies target multiple CD137-expressing cell types, including activated CD8⁺ T-cells, Tregs, follicular Tregs, and follicular dendritic cells.

CD97/ADGRE5 Attenuates the Induction of Adaptive Type 2 Immune Responses in Allergic Asthma

August 28, 2026

[Nature Communications] Scientists investigated the function of CD97/ADGRE5, expressed in mouse and human immune and lung epithelial cells, in allergic asthma. A single CD97 antibody treatment before allergen sensitization worsens allergic responses, highlighting a role for CD97 in early immune regulation.

Unconventional Role of Hydroxymethylglutaryl-CoA Synthase 1 in Driving Pathogenic T17 Cell Immunity and Autoimmune Diseases

August 28, 2026

[Science Advances] Scientists demonstrated that HMGCS1, a cholesterol biosynthesis precursor enzyme, was highly induced by inflammatory cytokines and preferentially expressed by pathogenic T helper 17 cells in vitro and in vivo.

Reduced SRSF1 Expression Correlates with LCK Exon Skipping and Impaired Treg Induction in Immune Thrombocytopenia

August 28, 2026

[Blood] Researchers showed that CD4+ naive T cells from patients with immune thrombocytopenia exhibit diminished T cell receptor signaling and impaired in vitro Treg induction relative to healthy controls.

Metabolic Switch: Lymphocytes and the Onset of T Cell-Mediated Autoimmunity

August 28, 2026

[Cellular & Molecular Immunology] The authors highlight immunometabolism as a key mechanism in autoimmunity. Immunometabolic pathways represent a new avenue for precision immunotherapy, although challenges persist in targeting cells specifically without systemic toxicity.

H3.3 Chaperone Hira Primes the Effector Program and Function of Regulatory T Cells

August 28, 2026

[Science Advances] Scientists showed that the histone variant H3.3 is enriched in tissue Tregs compared to splenic Tregs and its chaperone Hira is a critical regulator of Treg effector program.

Epigenetic Regulation of B Cell Tolerance and Dysfunction in Autoimmune Disease

August 28, 2026

[Nature Reviews Immunology] Investigators describe the molecular mechanisms by which multiple epigenetic layers, encompassing DNA methylation, histone modification, chromatin remodelling, non-coding RNA regulation and RNA modification, collectively regulate normal B cell function and, when dysregulated, contribute to autoimmune pathogenesis.

Lupus Foundation of America Awards Grants to Early Career Scientists Advancing Understanding of Lupus and Targeted Treatment Pathways

August 14, 2026

[Lupus Foundation of America] The Lupus Foundation of America announced the recipients of the 2026 Gary S. Gilkeson Career Development Award. The two-year grant supports early career scientists at a pivotal time in their professions, providing funding for critical research studies and mentorship to foster the growth of the lupus research field.

UV Irradiation Drives Lineage-Specific MITF-Mediated Transcription of PD-L1 to Confer Immune Tolerance to UV-Mutated Melanocytes

August 14, 2026

[Immunity] Researchers investigated whether melanocyte-intrinsic transcriptional program(s) underlie immune tolerance to mutations resulting from UV radiation exposure.

Metabolic-Epigenetic Crosstalk in Innate Immune Cell Plasticity Within the Tumor Microenvironment

August 14, 2026

[Experimental & Molecular Medicine] Emerging evidence highlights the intricate interplay between metabolic reprogramming and epigenetic modifications in macrophages, neutrophils, and other innate immune populations within the tumor microenvironment.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.