Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Subscribe|Follow Us On

Lupus Foundation of America Awards Grants to Early Career Scientists Advancing Understanding of Lupus and Targeted Treatment Pathways

August 14, 2026

[Lupus Foundation of America] The Lupus Foundation of America announced the recipients of the 2026 Gary S. Gilkeson Career Development Award. The two-year grant supports early career scientists at a pivotal time in their professions, providing funding for critical research studies and mentorship to foster the growth of the lupus research field.

UV Irradiation Drives Lineage-Specific MITF-Mediated Transcription of PD-L1 to Confer Immune Tolerance to UV-Mutated Melanocytes

August 14, 2026

[Immunity] Researchers investigated whether melanocyte-intrinsic transcriptional program(s) underlie immune tolerance to mutations resulting from UV radiation exposure.

Metabolic-Epigenetic Crosstalk in Innate Immune Cell Plasticity Within the Tumor Microenvironment

August 14, 2026

[Experimental & Molecular Medicine] Emerging evidence highlights the intricate interplay between metabolic reprogramming and epigenetic modifications in macrophages, neutrophils, and other innate immune populations within the tumor microenvironment.

A Regulatory T Cell-Biased IL-2 Mutein Inhibits the Development of Allergen-Specific Th2 Cells and Allergic Asthma

August 14, 2026

[Journal of Allergy and Clinical Immunology] Investigators explored the effects of the IL-2 mutein Fc.mut24 on allergen-induced type 2 airway inflammation. Fc.mut24 therapy prevented allergic airway inflammation when delivered before type 2 effector T cell priming but was insufficient to overcome established allergen-specific type 2 responses.

Metabolic Rewiring of the Dendritic Cell-T Cell Axis: Tumor-Derived Barriers and Therapeutic Opportunities

August 14, 2026

[Experimental & Molecular Medicine] Scientists propose a framework that overlays the cancer-immunity cycle with major metabolic checkpoints, including glucose and amino acid competition, acidosis and lipid overload, to clarify how distinct metabolic stresses create immune bottlenecks at different stages of the anti-tumour response.

Receptor-Tethered Orthogonal IL-2 Enhances Regulatory T Cell Therapy

August 14, 2026

[Journal of Experimental Medicine] Researchers found that infusions of orthogonal IL-2 failed to enhance Tregs expressing a corresponding orthoIL-2 receptor in a mouse model of autoimmune diabetes. Engineering Tregs with an orthoIL-2 tethered to its receptor achieved selective autocrine signaling.

Intratumoral Regulatory T-Cell Ablation Mediates Tumor Control Systemically Without Autoimmunity

August 14, 2026

[Cancer Research] Investigators used intratumoral delivery (IT) of diphtheria toxin in Foxp3DTR mice to deplete Tregs within tumor tissues while leaving peripheral Tregs intact. Mechanistically, IT Tregs suppressed antitumor T cell responses by blocking the acquisition and presentation of tumor antigen by conventional type II dendritic cells.

A Novel CAF Population Coordinates Hyper-Suppressive Regulatory T Cell Recruitment and Localization in Lung Cancer

August 13, 2026

[Nature Immunology] Researchers identified a population of immunomodulatory cancer-associated fibroblasts (CAFs) that play a pivotal role in shaping the lung tumor microenvironment by driving the recruitment of a highly immunosuppressive subset of CXCR3+ Treg cells.

TIF1γ Regulates Stability of Regulatory T Cells during Inflammation

August 13, 2026

[Nature Immunology] Scientists showed that TIF1γ-deficient Treg cells lose Foxp3 expression and acquire effector phenotypes in a cell-intrinsic manner upon inflammatory challenge.

Immunomodulatory Effects of Regulatory T Cells Promote MSC Recruitment and Improve Titanium Osseointegration

August 13, 2026

[Acta Biomaterialia] Investigators found that adoptive transfer of Tregs to wild-type mice significantly decreased pro-inflammatory macrophage polarization and cytokine production both in vivo and in vitro.

Fecal Microbiome Transplant in Food Allergy in Humans and Mice Identifies a Role for Bile Acid Metabolites in Oral Tolerance

August 13, 2026

[Science Translational Medicine] Scientists evaluated, in a Phase I open-label trial, the safety and efficacy of oral encapsulated fecal microbiome transplantation (FMT) in 15 adults with peanut allergies. In responders, FMT increased tolerogenic RORγt+ Tregs and decreased T helper 2 cells.

Milk Osteopontin Alters the Infant Microbiome to Drive DC Hematopoiesis and Disease Tolerance

August 13, 2026

[Cell] Researchers demonstrated that the absence of milk-derived osteopontin (OPN), highly expressed in colostrum, predisposes neonatal mice to viral and bacterial severe lower respiratory infections, consequent to disrupted dendritic cell hematopoiesis in the developing liver and lung.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.