Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Proximity between LAG-3 and the T Cell Receptor Guides Suppression of T Cell Activation and Autoimmunity
[Cell] To exploit LAG-3’s proximity to T cell receptor (TCR) and maximize LAG-3-dependent T cell suppression, scientists developed an Fc-attenuated LAG-3/TCR inhibitory bispecific antibody to bypass the requirement of cognate peptide-MHC class II.
Chemosensor Receptors Are Lipid-Detecting Regulators of Macrophage Function in Cancer
[Nature Immunology] Researchers conducted an unbiased genome-wide CRISPR screen of primary macrophages. Their study confirmed the function of known regulators in tumor associated macrophage responses and revealed new insights into the behavior of these cells.
A Genome-Wide Association Study Integrated With Single-Cell and Bulk Profiles Uncovers Susceptibility Genes for Nasopharyngeal Carcinoma Involved in Tumorigenesis Via Regulation of T Cells
[Genome Biology] Scientists performed in-depth bioinformatic analysis and functional experiments for EOMES, finding that the nasopharyngeal carcinoma-risk alleles of four functional SNPs upregulate EOMES expression by promoting the activity of regulatory elements in T cells.
PD-1 Receptor Deficiency Enhances CD30 T Cell Function in Melanoma
[Nature Immunology] The authors demonstrated that PD-1 deficiency enhances the function of Treg cells through expression of a compensatory network of coinhibitory receptors.
Regulatory T Cells Attenuate Chronic Inflammation and Cardiac Fibrosis in Hypertrophic Cardiomyopathy
[Science Translational Medicine] Scientists reported that postmortem and explanted human hypertrophic cardiomyopathy (HCM) hearts exhibited chronic focal leukocyte infiltration and prominent activation of immune cells. Gene set enrichment analysis revealed that active immune responses were present in the mid- and late-stage HCM human hearts and in mouse hearts from several HCM mouse models.
Myeloid MAS-Driven Macrophage Efferocytosis Promotes Resolution in Ischemia-Stressed Mouse and Human Livers
[Science Translational Medicine] Researchers showed that mice with systemic, Kupffer cell–specific, or myeloid cell–specific Mas1 deficiency were vulnerable to liver ischemia-reperfusion injury.
Beyond T Cell Subsets: Stemness and Adaptation Redefining Immunity and Immunotherapy
[Cellular & Molecular Immunology] Targeting stem-like CD4+ T cells offers great therapeutic potential: disrupting their persistence could mitigate autoimmune pathology and transplant rejection, whereas enhancing their effector capacity could improve antitumor immunity.
Pattern Recognition Receptors: Function, Regulation, and Therapeutic Potential
[Signal Transduction and Targeted Therapy] The authors explore the therapeutic potential of targeting pattern recognition receptors in treating infectious, inflammatory, autoimmune, and malignant diseases, underscoring their importance in advancing immunological research and precision medicine.
Earendil Labs Announces Initiation of a Phase I Study of a Half-Life Extended Novel Anti-TL1A Antibody
[Earendil Labs (BioSpace)] Earendil Labs announced that it has completed cohort 1 dosing in a Phase I trial for a novel anti-TL1A antibody (HXN-1001). HXN-1001 is a half-life extended next-generation anti-TL1A antibody for the treatment of patients with inflammatory bowel diseases, including ulcerative colitis, Crohn's disease, and other immunological disorders.
SAMSN1 Causes Sepsis Immunosuppression by Inducing Macrophages to Express Coinhibitory Molecules That Cause T Cell Exhaustion via KEAP1-NRF2 Signaling
[Chinese Medical Journal] Genetic deletion of Sterile Alpha Motif, Src Homology 3 domain and nuclear localization signal 1 (SAMSN1) in a murine sepsis model improves T cell survival, elevates T cell cytolytic activity, and activates T cell signaling transduction.
FLT3 Ligand Regulates Expansion of Regulatory T Cells Induced by Regulatory Dendritic Cells Isolated from Gut-Associated Lymphoid Tissues through the Notch Pathway
[Chinese Medical Journal] In vivo experiments established that fms-like tyrosine kinase 3 ligand (FLT3L) promoted regulatory dendritic cell expansion and restored Treg balance in dextran sulfate sodium-induced colitis models, thereby ameliorating colitis symptoms in mice.
Rescuing Dendritic Cell Interstitial Motility Sustains Antitumour Immunity
[Nature] Through longitudinal analysis of human and mouse tumours, researchers observed a progressive decrease in migratory conventional dendritic cells in the tumour draining lymph nodes during tumour progression.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
