Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Fasting-Mimicking Diet-Enriched Bifidobacterium pseudolongum Suppresses Colorectal Cancer by Inducing Memory CD8+ T Cells

[Gut] Scientists investigated how a fasting-mimicking diet (FMD) protected against colorectal cancer (CRC) via gut microbiota modulation. They assessed probiotic species enrichment in FMD-treated CRC mice using fecal metagenomic sequencing.

Terminal Differentiation and Persistence of Effector Regulatory T Cells Essential for Preventing Intestinal Inflammation

[Nature Immunology] Researchers characterized distinct colonic effector Treg cell transcriptional programs. Attenuated T cell receptor (TCR) signaling and acquisition of substantial TCR-independent functionality seemed to facilitate the terminal differentiation of a population of colonic effector Treg cells that were distinguished by stable expression of the immunomodulatory cytokine IL-10.

The Lactate Receptor HCAR1 Drives the Recruitment of Immunosuppressive PMN-MDSCs in Colorectal Cancer

[Nature Immunology] Investigators found that activation of the lactate receptor HCAR1 signaling pathway induced the expression of chemokines CCL2 and CCL7 in colorectal tumor cells, leading to the recruitment of immunosuppressive CCR2+ polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) to the tumor microenvironment.

Stem-Like Memory and Precursors of Exhausted T Cells Share a Common Progenitor Defined by ID3 Expression

[Science Immunology] Researchers demonstrated that during acute infection, the transcriptional regulator inhibitor of DNA binding 3 identifies stem-like T cells uniquely adapted to generate precursors of exhausted T cells in response to chronic infection or cancer.

Monocytes and Interstitial Macrophages Contribute to Hypoxic Pulmonary Hypertension

[Journal of Clinical Investigation] Researchers observed in hypoxia-exposed mice an increase in resident interstitial macrophages, which expanded through proliferation and expressed the monocyte recruitment ligand CCL2. They also observed an increase in CCR2+ macrophages through recruitment, which expressed the protein thrombospondin-1 that functionally activated TGF-beta to cause vascular disease.

In Situ Bioconjugation of Synthetic Peptides onto Universal Chimeric Antigen Receptor T Cells for Targeted Cancer Immunotherapies

[ACS Nano] Investigators demonstrated the versatility and therapeutic potential of “Cyborg” CAR T-cell therapies that utilized synthetic biomaterials to direct CAR T cell activity via highly selective bioconjugation that occurs in vivo.

Harnessing Macrophage-Drug Conjugates for Allogeneic Cell-Based Therapy of Solid Tumors via the TRAIN Mechanism

[Nature Communications] Scientists presented a Macrophage-Drug Conjugate platform technology that enables loading macrophages with ferritin-drug complexes. They first showed that macrophages actively take up human heavy chain ferritin in vitro via macrophage scavenger receptor 1.

B Cells in Non-Lymphoid Tissues

[Nature Reviews Immunology] The authors review the role of B cells in peripheral tissues in homeostasis and disease and discuss the newly identified cellular and molecular signals that are involved in regulating their activity.

HCW Biologics Granted FDA Clearance to Evaluate One of the Company’s Lead Product Candidates in a First-In-Human Phase 1 Clinical Trial

[HCW Biologics, Inc.] HCW Biologics, Inc. announced that it has received clearance for its Investigational New Drug Application from the US FDA to initiate a first-in-human Phase I dose escalation clinical trial to evaluate one of its lead drug candidates, HCW9302, in patients with moderate-to-severe alopecia areata, a common autoimmune disease in humans that currently has no curative FDA approved treatments.

Loss of SGK1 Supports Metastatic Colonization in Hepatocellular Carcinoma by Promoting Resistance to T Cell-Mediated Immunity

[Journal of Hepatology] Utilizing in vivo CRISPR library screening in murine HCC metastasis models under conditions of both intact and depleted T cell immunity, the authors identified genes critical to tumor immune evasion during metastatic colonization, and investigated intrinsic mechanisms.

Engineered Immunomodulatory Extracellular Vesicles from Epithelial Cells with the Capacity for Stimulation of Innate and Adaptive Immunity in Cancer and Autoimmunity

[ACS Nano] To address whether epithelial cell-derived extracellular vesicles (EVs) can be modified to acquire the capacity to induce an immune response, researchers engineered 293T EVs to harbor the immunomodulatory molecules CD80, OX40L, and PD-L1.

CircPRKD3-Loaded Exosomes Concomitantly Elicit Tumor Growth Inhibition and Glioblastoma Microenvironment Remodeling via Inhibiting STAT3 Signaling

[Neuro-Oncology] Investigators evaluated the significance of novel immune-related glioblastoma stem cell-derived exosomal circular RNAs in the glioma microenvironment

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

spot_img