Scientists showed that inhibiting lipid synthesis and metabolic signaling that were dependent on sterol-regulatory-element-binding proteins in Treg cells unleashed effective antitumor immune responses without autoimmune toxicity.
[Nature]
Lim, S. A., Wei, J., Nguyen, T.-L. M., Shi, H., Su, W., Palacios, G., Dhungana, Y., Chapman, N. M., Long, L., Saravia, J., Vogel, P., & Chi, H. (2021). Lipid signalling enforces functional specialization of T reg cells in tumours. Nature, 1–6. https://doi.org/10.1038/s41586-021-03235-6 Cite
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