CCL7 Recruits cDC1 to Promote Antitumor Immunity and Facilitate Checkpoint Immunotherapy to Non-Small Cell Lung Cancer

Researchers demonstrated that CCL7 facilitated anti-PD-1 therapy for the KrasLSL−G12D/+Tp53fl/fl and the KrasLSL−G12D/+Lkb1fl/fl NSCLC mouse models by recruiting conventional DC 1 into the TME to promote T cell expansion.
[Nature Communications]
Zhang, M., Yang, W., Wang, P., Deng, Y., Dong, Y.-T., Liu, F.-F., Huang, R., Zhang, P., Duan, Y.-Q., Liu, X.-D., Lin, D., Chu, Q., & Zhong, B. (2020). CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nature Communications, 11(1), 6119. https://doi.org/10.1038/s41467-020-19973-6 Cite
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Multiplexed CRISPR/CAS9-Mediated Engineering of Pre-Clinical Mouse Models Bearing Native Human B Cell Receptors

Scientists report a one‐step CRISPR/Cas9 KI methodology to combine the insertion of human germline immunoglobulin heavy and light chains at their endogenous loci in mice.
[EMBO Journal]
Wang, X., Ray, R., Kratochvil, S., Melzi, E., Lin, Y.-C., Giguere, S., Xu, L., Warner, J., Cheon, D., Liguori, A., Groschel, B., Phelps, N., Adachi, Y., Tingle, R., Wu, L., Crotty, S., Kirsch, K. H., Nair, U., Schief, W. R., & Batista, F. D. (2020). Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors. The EMBO Journal, n/a(n/a), e105926. https://doi.org/10.15252/embj.2020105926 Cite
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Intestinal Regulatory T Cell Induction by β-Elemene Alleviates the Formation of Fat Tissue-Related Inflammation

Oral administration of β-elemene, contained in various foodstuffs, downregulated expressions of inflammatory cytokines and increased Foxp3+CD4+ T cells in adipose tissue of obese mice.
[iScience]
Zhou, Y., Takano, T., Wang, Y., Li, X., Wang, R., Wakatsuki, Y., Nakajima-Adachi, H., Tanokura, M., Miyakawa, T., & Hachimura, S. (2020). Intestinal Regulatory T Cell Induction by β-Elemene Alleviates the Formation of Fat Tissue-Related Inflammation. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101883 Cite
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The Role of Natural Killer Cell in Gastrointestinal Cancer: Killer or Helper

The authors discuss natural killer cells’ cytotoxicity and modulation function in gastrointestinal cancer and the current application in clinical therapy.
[Oncogene]
Wang, F., Lau, J. K. C., & Yu, J. (2020). The role of natural killer cell in gastrointestinal cancer: killer or helper. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01561-z Cite
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Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis

Using genetically modified mouse models of spontaneous colorectal and lung cancers, researchers found that MTDH promotes cancer progression by facilitating Wnt activation and by inducing cytotoxic T cell exhaustion, respectively.
[Cancer Research]
Shen, M., Xie, S., Rowicki, M., Michel, S., Wei, Y., Hang, X., Wan, L., Lu, X., Yuan, M., Jin, J. F., Jaschinski, F., Zhou, T., Klar, R., & Kang, Y. (2020). Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1876 Cite
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European Commission Approves Janssen’s TREMFYA®▼ (Guselkumab), a First-in-Class Treatment for Active Psoriatic Arthritis (PsA)

The Janssen Pharmaceutical Companies of Johnson & Johnson announced that the European Commission has approved TREMFYA®▼ for the treatment of adult patients with active psoriatic arthritis who have had an inadequate response or who have been intolerant to a prior disease-modifying antirheumatic drug therapy.
[Janssen, Inc.]
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Detection of Immunogenic Cell Death and Its Relevance for Cancer Therapy

Scientists outline methodological approaches for measuring immunogenic cell death markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer regimens, and the identification of optimal therapeutic combinations for the clinical management of cancer.
[Cell Death & Disease]
Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020). Detection of immunogenic cell death and its relevance for cancer therapy. Cell Death & Disease, 11(11), 1–13. https://doi.org/10.1038/s41419-020-03221-2 Cite
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Axl and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Anti-Tumor Immunity

Scientists ablated Axl on tumor cells using CRISPR/Cas9 gene editing, and by targeting Mertk in the tumor microenvironment, they observed distinct functions of TAM as oncogenic kinases as well as inhibitory immune receptors.
[Cancer Research]
Davra, V., Kumar, S., Geng, K., Calianese, D., Mehta, D., Gadiyar, V., Kasikara, C., Lahey, K. C., Chang, Y., Wichroski, M., Gao, C., Lorenzo, M. S. D., Kotenko, S. V., Bergsbaken, T., Mishra, P. K., Gause, W. C., Quigley, M., Spires, T. E., & Birge, R. B. (2020). Axl and Mertk receptors cooperate to promote breast cancer progression by combined oncogenic signaling and evasion of host anti-tumor immunity. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2066 Cite
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Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice

Immune profiling results revealed unique immune diversity following each experimental condition, suggesting each stressor results in distinct circulating immune responses, with clear consequences for deep spaceflight.
[iScience]
Paul, A. M., Cheng-Campbell, M., Blaber, E. A., Anand, S., Bhattacharya, S., Zwart, S. R., Crucian, B. E., Smith, S. M., Meller, R., Grabham, P., & Beheshti, A. (2020). Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101747 Cite
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LncRNA lncLy6C Induced by Microbiota Metabolite Butyrate Promotes Differentiation of Ly6Chigh to Ly6Cint/Neg Macrophages Through lncLy6C/C/EBPβ/Nr4A1 Axis

Researchers found that lncLy6C, a novel ultraconserved lncRNA, promotes differentiation of Ly6Chigh inflammatory monocytes into Ly6Clow/neg resident macrophages.
[Cell Discovery]
Gao, Y., Zhou, J., Qi, H., Wei, J., Yang, Y., Yue, J., Liu, X., Zhang, Y., & Yang, R. (2020). LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6C high to Ly6C int/neg macrophages through lncLy6C /C/EBPβ/Nr4A1 axis. Cell Discovery, 6(1), 1–14. https://doi.org/10.1038/s41421-020-00211-8 Cite
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Pik3c3 Deficiency in Myeloid Cells Imparts Partial Resistance to Experimental Autoimmune Encephalomyelitis Associated with Reduced IL-1β Production

Scientists investigated the role of PIK3C3 in myeloid cell biology using myeloid cell-specific Pik3c3-deficient mice.
[Cellular & Molecular Immunology]
Yang, G., Song, W., Xu, J., Postoak, J. L., Cheng, F., Martinez, J., Zhang, J., Wu, L., & Van Kaer, L. (2020). Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production. Cellular & Molecular Immunology, 1–16. https://doi.org/10.1038/s41423-020-00589-1 Cite
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