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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
The Next Generation of Immunotherapies for Lung Cancers
[Nature Reviews Clinical Oncology] Scientists provide an overview of emerging immunotherapies in clinical development for NSCLC and/or small cell lung cancer, including novel immune-checkpoint modulators, immune cell engagers, adoptive cell therapies, and therapeutic cancer vaccines.
Lactate Dehydrogenase B Facilitates Disulfidptosis and Exhaustion of Tumor-Infiltrating CD8+ T Cells
[Nature Cell Biology] Researchers demonstrated that lactate dehydrogenase B facilitates intratumoural CD8+ T cell disulfidptosis and exhaustion, leading to impaired antitumour immunity.
The T follicular helper/T follicular helper regulatory pathway in FVIII immune responses in mice.
[Blood] Investigators reported that FVIII immunization significantly increases the follicular regulatory T cells in the spleens of FVIII inhibitor-producing FVIIInull mice compared to saline-treated controls and non-inhibitor-producing animals.
Active Chemical Messenger-Driven Immune Activation via Electrochemical Patch for Tumor Vaccination.
[ACS nano] Taking hypochlorous acid (HClO) as a model chemical messenger, a wearable bioelectronic patch capable of electrocatalytically generating HClO to activate immunity for in situ tumor vaccination was designed.
Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell population expansion.
[Molecular systems biology] Iterative model predictions and sequential co-stimulation experiments revealed how complex non-monotonic integration of BCR and CD40 signals controls positive and negative selection of B-cells.
Sustained macrophage reprogramming is required for CD8+ T cell-dependent long-term tumor eradication.
[Cancer immunology research] Researchers uncovered the vulnerability of transient tumor-associated macrophages reprogramming and show that it can be overcome by repeated myeloid cell treatment administrations to sustain efficient antitumor immune responses.
AREG+ Regulatory T Cells Mediating Myocardial Repair and Neovascularization after Myocardial Infarction
[Molecular Medicine] Scientists demonstrated that Treg activation promotes tissue repair and improves cardiac function after acute myocardial infarction, although it does not significantly impact angiogenesis or endothelial cell behaviors.
Immunological Insights into Role of Th9 and Treg Cell Homeostasis and Cytokines Dynamics in the Progression of Diabetic Nephropathy
[International Reviews of Immunology] Scientists unveiled immune cell and cytokine intricacies in diabetic nephropathy (DN). The high T helper 9/Treg ratio in type 2 diabetes mellitus and DN suggests immune tolerance loss, potentially influencing DN development.
Exploring the Molecular Mechanisms of Lactylation-Related Biological Functions and Immune Regulation in Sepsis-Associated Acute Kidney Injury
[Clinical and Experimental Medicine] Scientists found the potential roles of lactylation-related genes in sepsis-associated acute kidney injury pathogenesis, particularly their association with immune regulation and cell-type specificity.
Integrated Transcriptomic, Metabolomic, and Lipidomic Analyses Reveal a Unique Lipid Profile of Regulatory T Cells upon Activation
[Immunobiology] Investigators combined transcriptomic, metabolomic, and lipidomic analyses to dissect the metabolic dynamics of Tregs upon activation.
Therapeutic Potential of Polyphenols in Targeting Th17/Treg Balance for Intestinal Barrier Maintenance
[Food Science & Nutrition] The authors highlight how the Th17/Treg balance affects intestinal permeability, and recent findings regarding possible effects and the molecular mechanism of polyphenols in regulating the Th17/Treg balance, to provide new potential therapeutic strategies for damaged intestinal barrier treatment preclinically and clinically.
Quell Therapeutics Achieves Key Milestone in Its CAR-Treg Cell Therapy Program for Inflammatory Bowel Disease
[Quell Therapeutics, Ltd.] Quell Therapeutics, Ltd. announced that AstraZeneca has selected a lead Treg cell therapy candidate to progress from the Inflammatory Bowel Disease program.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
