Nanoparticles were assessed in vivo for retention, bio-distribution and immunoreactivity. Cyclodextrin molecules via polyethylene glycol induced a temporary blood monocyte response and was cleared effectively from the body through the urine system in mice.
[Journal of Cellular and Molecular Medicine]
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The immuno‐reactivity of polypseudorotaxane functionalized magnetic CDMNP‐PEG‐CD nanoparticles - Lan - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved November 24, 2020, from https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16109 Cite
The authors summarize the discovery and development of Tregs, and discuss the outstanding challenges of Treg cell therapy and its future prospects for routine use in liver transplantation.
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Regulatory T Cell Therapy Following Liver Transplantation - Yu - - Liver Transplantation - Wiley Online Library. (n.d.). Retrieved November 24, 2020, from https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/lt.25948 Cite
Scientists review the recent findings in post-translational modifications in macrophages and T cells and speculate whether they could be of use in the effort to develop therapeutics for immune-related diseases.
CD34‐CD42b platelet‐targeting bispecific antibodies were designed to simultaneously recognize HSCs and platelets. After inhalation delivery, PT‐BsAbs reached the lungs and conjoined HSCs and platelets.
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Liu, M., Lutz, H., Zhu, D., Huang, K., Li, Z., Dinh, P.-U. C., Gao, J., Zhang, Y., & Cheng, K. (n.d.). Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury. Advanced Science, n/a(n/a), 2002127. https://doi.org/https://doi.org/10.1002/advs.202002127 Cite
Scientists identified a new phase of functional compensation following acute liver injury that occurs prior to cellular proliferation.
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Functional compensation precedes recovery of tissue mass following acute liver injury | Nature Communications. (n.d.). Retrieved November 24, 2020, from https://www.nature.com/articles/s41467-020-19558-3 Cite
Scientists demonstrated that a lead cyclic dinucleotide carrier formulation can enhance stimulator of interferon gene activation in vivo in a model of intratumoral immunotherapy.
[Advanced Healthcare Materials]
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Amphiphilic Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING Agonists - Nguyen - - Advanced Healthcare Materials - Wiley Online Library. (n.d.). Retrieved November 24, 2020, from https://onlinelibrary.wiley.com/doi/10.1002/adhm.202001056 Cite
Researchers identified the E3 ubiquitin ligase Peli1 as an important regulator of T cell metabolism and antitumor immunity. Peli1 ablation profoundly promotes tumor rejection, associated with increased tumor‐infiltrating CD4 and CD8 T cells.
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The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses | The EMBO Journal. (n.d.). Retrieved November 24, 2020, from https://www.embopress.org/doi/abs/10.15252/embj.2020104532 Cite
Scientists studied the effects of high-dose per fraction radiotherapy with and without anti-Gr-1 using syngeneic murine allograft prostate cancer models. The dynamic change of immune populations, including tumor-infiltrating lymphocytes, T-regulatory cells, and myeloid-derived suppressive cells was evaluated using flow cytometry and immunohistochemistry.
[Clinical Cancer Research]
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High-Dose per Fraction Radiotherapy Induces Both Anti-Tumor Immunity and Immunosuppressive Responses in Prostate Tumors | Clinical Cancer Research. (n.d.). Retrieved November 24, 2020, from https://clincancerres.aacrjournals.org/content/early/2020/11/20/1078-0432.CCR-20-2293 Cite
To increase the efficacy of AT1413 as a therapeutic antibody, researchers generated two different formats of bispecific T-cell engaging antibodies to both CD43s and CD3ε.
[Cancer Immunology Immunotherapy]
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Melanoma cells can be eliminated by sialylated CD43 × CD3 bispecific T cell engager formats in vitro and in vivo | SpringerLink. (n.d.). Retrieved November 24, 2020, from https://link.springer.com/article/10.1007/s00262-020-02780-9 Cite
Researchers examined expression of RIPK1 protein and mRNA in both human and mouse atherosclerotic lesions, and using loss-of-function approaches in vitro in macrophages and endothelial cells to measure inflammatory responses. They administered weekly injections of RIPK1 anti-sense oligonucleotides to Apoe-/- mice fed a cholesterol-rich diet for eight weeks.
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Karunakaran Denuja, Nguyen My-Anh, Geoffrion Michele, Vreeken Dianne, Lister Zachary, Cheng Henry S., Otte Nicola, Essebier Patricia, Wyatt Hailey, Kandiah Joshua W., Jung Richard, Alenghat Francis J., Mompeon Ana, Lee Richard, Pan Calvin, Gordon Emma, Rasheed Adil, Lusis Aldons J., Liu Peter, … Rayner Katey J. (n.d.). RIPK1 Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.118.038379 Cite
Scientists report an alternative mechanism of targeted protein degradation, in which a small molecule induced the highly specific, reversible polymerization of a target protein, followed by its sequestration into cellular foci and subsequent degradation.
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Słabicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S. S., Di Genua, C., Donovan, K. A., Sperling, A. S., Hunkeler, M., Tsai, J. M., Sharma, R., Guirguis, A., Zou, C., Chudasama, P., Gasser, J. A., Miller, P. G., Scholl, C., Fröhling, S., Nowak, R. P., … Ebert, B. L. (2020). Small-molecule-induced polymerization triggers degradation of BCL6. Nature, 1–5. https://doi.org/10.1038/s41586-020-2925-1 Cite