Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
MCRS1 Sensitizes T Cell–Dependent Immunotherapy by Augmenting MHC-I Expression in Solid Tumors
[Journal of Experimental Medicine] Researchers uncovered that MCRS1 sensitized cancer cells to T cell immunity by transcriptionally subverting MHC-I suppression. This enhanced the effectiveness of α-PD-1 therapy in mice and humans, paving the way for further improvement in immunotherapy against solid tumors.
Insulin-Like Growth Factor 2 Drives Fibroblast-Mediated Tumor Immunoevasion and Confers Resistance to Immunotherapy
[Journal of Clinical Investigation] Using mice with systemic or fibroblast-specific deletion of insulin-like growth factor 2 (IGF2), scientists demonstrated that IGF2 deficiency enhanced the infiltration and cytotoxic activity of CD8+ T cells, leading to a reduction in tumor burden.
Tumor Cell-Derived Spermidine Promotes a Pro-Tumorigenic Immune Microenvironment in Glioblastoma via CD8+ T Cell Inhibition
[Journal of Clinical Investigation] Investigators demonstrated that the polyamine metabolite spermidine (SPD) was elevated in the glioblastoma tumor microenvironment. Exogenous administration of SPD drove tumor aggressiveness in an immune-dependent manner in pre-clinical mouse models via reduction of CD8+ T cell frequency and reduced cytotoxic function.
Selective Regulation of IFN-γ and IL-4 Co-Producing Unconventional T Cells by Purinergic Signaling
[Journal of Experimental Medicine] Scientists showed that MAIT, γδT, and NKT cells expressed P2RX7 and were sensitive to P2RX7-mediated cell death. Mouse peripheral T-bet+ MAIT1, γδT1, and NKT1 cells, especially in the liver, co-express ARTC2 and P2RX7.
NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma
[Cancer Discovery] The authors demonstrated that NOTCH1, an understudied oncogene in hepatocellular carcinoma, elicits sexually dimorphic anti-tumor immunity and response to FDA-approved immunotherapies.
Salmonella Cancer Therapy Metabolically Disrupts Tumours at the Collateral Cost of T Cell Immunity
[EMBO Molecular Medicine] Researchers used distal T cell receptor and IFNγ reporter mice and a colorectal cancer model to interrogate T cell activity during bacterial cancer therapy with attenuated Salmonella enterica Typhimurium.
TNFR2 Blockade Promotes Antitumoral Immune Response in PDAC by Targeting Activated Treg and Reducing T Cell Exhaustion
[Journal of Immunotherapy of Cancer] Scientists hypothesized that TNFR2 inhibition using a blocking monoclonal antibody could shift the Treg-effector T cell balance in pancreatic ductal adenocarcinoma, thus enhancing antitumoral responses.
Neurotrophic Factor Neuritin Modulates T Cell Electrical and Metabolic State for the Balance of Tolerance and Immunity
[eLife] Researchers identified a novel immune function of the neurotrophic factor Nrn1 in regulating the T cell metabolic state in a cell context-dependent manner and modulating the outcome of an immune response.
IL-37 Suppresses CNS Autoimmunity by Increasing the Frequency of Treg Cells and Reducing CD4+ T Cell-Derived IL-10 Production
[Journal of Neuroinflammation] Investigators examined the effect of IL-37 in an experimental autoimmune encephalomyelitis model after disease onset to determine if it was protective.
Gut Microbiota Contributes to the Intestinal and Extraintestinal Immune Homeostasis by Balancing Th17/Treg Cells
[International Immunopharmacology] The authors provided an overview of gut microbiota, along with Th17/Treg cell differentiation and cytokine production.
Quell Therapeutics Achieves Milestone for Type 1 Diabetes CAR-Treg Cell Therapy Program
[Quell Therapeutics, Ltd.] Quell Therapeutics, Ltd. announced that AstraZeneca has selected a candidate to progress in the Type 1 Diabetes Treg cell therapy program.
The Glucocorticoid Receptor Potentiates Aldosterone-Induced Transcription by the Mineralocorticoid Receptor
[Proceedings of The National Academy of Sciences of The United States of America] Researchers analyzed the impact of glucocorticoid receptor coexpression on mineralocorticoid receptor genome-wide transcriptional responses and chromatin binding upon activation by aldosterone and glucocorticoids, both physiological ligands of this receptor.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
