Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

MCRS1 Sensitizes T Cell–Dependent Immunotherapy by Augmenting MHC-I Expression in Solid Tumors

[Journal of Experimental Medicine] Researchers uncovered that MCRS1 sensitized cancer cells to T cell immunity by transcriptionally subverting MHC-I suppression. This enhanced the effectiveness of α-PD-1 therapy in mice and humans, paving the way for further improvement in immunotherapy against solid tumors.

Insulin-Like Growth Factor 2 Drives Fibroblast-Mediated Tumor Immunoevasion and Confers Resistance to Immunotherapy

[Journal of Clinical Investigation] Using mice with systemic or fibroblast-specific deletion of insulin-like growth factor 2 (IGF2), scientists demonstrated that IGF2 deficiency enhanced the infiltration and cytotoxic activity of CD8+ T cells, leading to a reduction in tumor burden.

Tumor Cell-Derived Spermidine Promotes a Pro-Tumorigenic Immune Microenvironment in Glioblastoma via CD8+ T Cell Inhibition

[Journal of Clinical Investigation] Investigators demonstrated that the polyamine metabolite spermidine (SPD) was elevated in the glioblastoma tumor microenvironment. Exogenous administration of SPD drove tumor aggressiveness in an immune-dependent manner in pre-clinical mouse models via reduction of CD8+ T cell frequency and reduced cytotoxic function.

Selective Regulation of IFN-γ and IL-4 Co-Producing Unconventional T Cells by Purinergic Signaling

[Journal of Experimental Medicine] Scientists showed that MAIT, γδT, and NKT cells expressed P2RX7 and were sensitive to P2RX7-mediated cell death. Mouse peripheral T-bet+ MAIT1, γδT1, and NKT1 cells, especially in the liver, co-express ARTC2 and P2RX7.

NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma

[Cancer Discovery] The authors demonstrated that NOTCH1, an understudied oncogene in hepatocellular carcinoma, elicits sexually dimorphic anti-tumor immunity and response to FDA-approved immunotherapies.

Salmonella Cancer Therapy Metabolically Disrupts Tumours at the Collateral Cost of T Cell Immunity

[EMBO Molecular Medicine] Researchers used distal T cell receptor and IFNγ reporter mice and a colorectal cancer model to interrogate T cell activity during bacterial cancer therapy with attenuated Salmonella enterica Typhimurium.

TNFR2 Blockade Promotes Antitumoral Immune Response in PDAC by Targeting Activated Treg and Reducing T Cell Exhaustion

[Journal of Immunotherapy of Cancer] Scientists hypothesized that TNFR2 inhibition using a blocking monoclonal antibody could shift the Treg-effector T cell balance in pancreatic ductal adenocarcinoma, thus enhancing antitumoral responses.

Neurotrophic Factor Neuritin Modulates T Cell Electrical and Metabolic State for the Balance of Tolerance and Immunity

[eLife] Researchers identified a novel immune function of the neurotrophic factor Nrn1 in regulating the T cell metabolic state in a cell context-dependent manner and modulating the outcome of an immune response.

IL-37 Suppresses CNS Autoimmunity by Increasing the Frequency of Treg Cells and Reducing CD4+ T Cell-Derived IL-10 Production

[Journal of Neuroinflammation] Investigators examined the effect of IL-37 in an experimental autoimmune encephalomyelitis model after disease onset to determine if it was protective.

Gut Microbiota Contributes to the Intestinal and Extraintestinal Immune Homeostasis by Balancing Th17/Treg Cells

[International Immunopharmacology] The authors provided an overview of gut microbiota, along with Th17/Treg cell differentiation and cytokine production.

Quell Therapeutics Achieves Milestone for Type 1 Diabetes CAR-Treg Cell Therapy Program

[Quell Therapeutics, Ltd.] Quell Therapeutics, Ltd. announced that AstraZeneca has selected a candidate to progress in the Type 1 Diabetes Treg cell therapy program.

The Glucocorticoid Receptor Potentiates Aldosterone-Induced Transcription by the Mineralocorticoid Receptor

[Proceedings of The National Academy of Sciences of The United States of America] Researchers analyzed the impact of glucocorticoid receptor coexpression on mineralocorticoid receptor genome-wide transcriptional responses and chromatin binding upon activation by aldosterone and glucocorticoids, both physiological ligands of this receptor.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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