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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Differential Roles of Human CD4+ and CD8+ Regulatory T Cells in Controlling Self-rReactive Immune Responses
[Nature Immunology] Scientists analyzed the relative contributions of CD4+ regulatory T cells expressing Forkhead box protein P3 and CD8sup>+ regulatory T cells expressing killer cell immunoglobulin-like receptors to the control of autoreactive T and B lymphocytes in human tonsil-derived immune organoids.
ETV7 Limits the Antiviral and Antitumor Efficacy of CD8+ T Cells by Diverting their Fate Toward Exhaustion
[Nature Cancer] Scientists demonstrated a decisive role for ETS variant 7 (ETV7) in driving CD8+T cell terminal exhaustion and revealed that ETV7 may be a promising target and biomarker for improving the efficacy of cancer immunotherapy.
Endothelial Sting-jak1 Interaction Promotes Tumor Vasculature Normalization and Antitumor Immunity
[Journal of Clinical Investigation] Investigators demonstrated that endothelial stimulator of interferon genes (STING) expression was critical for STING agonist-induced antitumor activity. STING activation in endothelium promoted vessel normalization and CD8+ T cell infiltration but not IFN-γ or CD4+ T cells.
Engineered Antigen-Specific T Regulatory Cells Suppress Autoreactivity to the Anti-Glomerular Basement Membrane Disease Antigen
[Kidney international] Scientists investigated whether Tregs engineered to express glomerular basement membrane-T cell receptors specific for α3(IV)NC1135- 145 better suppress autoimmunity.
Personalized Nanovaccine Based on STING-Activating Nanocarrier for Robust Cancer Immunotherapy
[ACS Nano] Investigators developed a minimalist nanovaccine that exploits a dual immunofunctional polymeric nanoplatform to encapsulate ovalbumin via electrostatic interaction when the nanocarrier served as both STING agonist and immune adjuvant in dendritic cells.
Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression
[ACS Nano] Researchers underscored the potential of particle-based therapy to reverse autoimmunity in disease-relevant models without compromising immune competence, setting it apart from existing treatments.
Increased SOAT2 Expression in Aged Regulatory T Cells is Associated with Altered Cholesterol Metabolism and Reduced Anti-Tumor Immunity
[Nature Communications] Researchers found that an endoplasmic reticulum transmembrane enzyme, sterol O-acyltransferase 2 (SOAT2), was overexpressed in regulatory T cells from elderly patients with lung squamous cell carcinoma.
Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy
[Cancer Research] Researchers analyzed the tumor-infiltrating lymphocytes in murine models of brain metastasis that responded to anti-CTLA-4 monoclonal antibody (mAb) to anti-PD-1 mAb.
ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer
[Cancer Research] Investigators showed that combining DNA methyltransferase and poly (ADP-ribose) polymerase inhibitors upregulated expression of the nucleic-acid sensor NFX1-type zinc finger-containing 1 protein (ZNFX1).
T Cells in Cardiac Health and Disease
[Journal of Clinical Investigation] The authors explore the diverse roles of T cell subsets, including Th1, Th17, γδ T cells, and Tregs, in myocardial inflammatory processes such as autoimmune myocarditis and myocardial infarction.
Trump Administration’s Abrupt Cancellation of Scientific Meetings Prompts Confusion, Concern
[Stat] A flurry of scientific gatherings and panels across federal science agencies were canceled on Jan. 22, at a time of heightened sensitivity about how the Trump administration will shift the agencies’ policies and day-to-day affairs.
AbbVie and Neomorph Announce Collaboration to Develop Molecular Glue Degraders for Oncology and Immunology
[AbbVie (PR Newswire)] AbbVie and Neomorph, Inc. announced a collaboration and option-to-license agreement to develop novel molecular glue degraders for multiple targets across oncology and immunology.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
