Scientists report a non-conventional, T cell-intrinsic function for Nod2 in suppression of Th17 immunity and experimental uveitis.
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Napier, R. J., Lee, E. J., Davey, M. P., Vance, E. E., Furtado, J. M., Snow, P. E., Samson, K. A., Lashley, S. J., Brown, B. R., Horai, R., Mattapallil, M. J., Xu, B., Callegan, M. C., Uebelhoer, L. S., Lancioni, C. L., Vehe, R. K., Binstadt, B. A., Smith, J. R., Caspi, R. R., & Rosenzweig, H. L. (2020). T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis. Nature Communications, 11(1), 5406. https://doi.org/10.1038/s41467-020-18961-0 Cite
The authors present a proton-driven nanotransformer-based vaccine, comprising a polymer–peptide conjugate-based nanotransformer and loaded antigenic peptide.
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Gong, N., Zhang, Y., Teng, X., Wang, Y., Huo, S., Qing, G., Ni, Q., Li, X., Wang, J., Ye, X., Zhang, T., Chen, S., Wang, Y., Yu, J., Wang, P. C., Gan, Y., Zhang, J., Mitchell, M. J., Li, J., & Liang, X.-J. (2020). Proton-driven transformable nanovaccine for cancer immunotherapy. Nature Nanotechnology, 1–12. https://doi.org/10.1038/s41565-020-00782-3 Cite
identify a unique granulocyte subset, with characteristics of an immature neutrophil, that had neuroprotective properties and drove CNS axon regeneration in vivo, in part via secretion of a cocktail of growth factors.
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Scientists found that the metabolic sensor peroxisome proliferator-activated receptor gamma was highly expressed in ILC2s of the lung and adipose tissue and increased responsiveness to IL-33.
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Using a model of cutaneous allergen exposure, scientists showed that allergens directly activated TRPV1 + sensory neurons leading to itch and pain behaviors.
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Perner, C., Flayer, C. H., Zhu, X., Aderhold, P. A., Dewan, Z. N. A., Voisin, T., Camire, R. B., Chow, O. A., Chiu, I. M., & Sokol, C. L. (2020). Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.001 Cite
Apellis Pharmaceuticals, Inc. and Swedish Orphan Biovitrum AB announced a strategic collaboration to accelerate the advancement of systemic pegcetacoplan, a targeted C3 therapy, for the treatment of multiple rare diseases with high unmet need that impact more than 275,000 patients globally.
[Apellis Pharmaceuticals, Inc.]
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Scientists look into the advancements in microfluidic technologies applied to researches on immune checkpoint blockade treatment and its potential shift from proof-of-principle stage to clinical application.
[Cancer Gene Therapy]
By mapping the long-term development of CD8+ T cell families derived from single naive precursors, scientists found that fate decisions made during the acute phase of murine cytomegalovirus infection could alter the level of memory inflation by more than 1,000-fold.
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Grassmann, S., Mihatsch, L., Mir, J., Kazeroonian, A., Rahimi, R., Flommersfeld, S., Schober, K., Hensel, I., Leube, J., Pachmayr, L. O., Kretschmer, L., Zhang, Q., Jolly, A., Chaudhry, M. Z., Schiemann, M., Cicin-Sain, L., Höfer, T., Busch, D. H., Flossdorf, M., & Buchholz, V. R. (2020). Early emergence of T central memory precursors programs clonal dominance during chronic viral infection. Nature Immunology, 1–11. https://doi.org/10.1038/s41590-020-00807-y Cite
Investigators summarize emerging aspects of antigen presentation, autoantibody production, and the application of novel therapeutic approaches in the characterization and treatment of autoimmune liver diseases.
[Cellular & Molecular Immunology]
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Scientists demonstrated that apoptosis induced by JQ1 was solely attributed to the pro-apoptotic protein Bim. Conversely, cell-cycle regulation by JQ1 was associated with multiple Myc-associated gene targets.
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Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation: Cell Reports. (n.d.). Retrieved October 23, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31279-1 Cite
Scientists report that ubiquitin-specific protease 19 acted as an anti-inflammatory switch that inhibited inflammatory responses and promoted M2-like macrophage polarization.
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Liu, T., Wang, L., Liang, P., Wang, X., Liu, Y., Cai, J., She, Y., Wang, D., Wang, Z., Guo, Z., Bates, S., Xia, X., Huang, J., & Cui, J. (2020). USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-00567-7 Cite