Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

OMRF Scientist Awarded $3.4 Million to Investigate Immune Cells

[Oklahoma Medical Research Foundation] The National Institutes of Health recently awarded Dr. Xiao-Hong Sun a $3.4 million grant to continue unraveling mysteries about innate lymphoid cells, including whether they may offer clues about the differences in immune reactions between children and adults.

Myeloid OTULIN Deficiency Couples RIPK3-Dependent Cell Death to Nlrp3 Inflammasome Activation and IL-1β Secretion

[Science Immunology] Scientists identified OTULIN deficiency as a cellular condition that licenses RIPK3-mediated cell death in murine macrophages, leading to Nlrp3 inflammasome activation and subsequent IL-1β secretion.

Enhanced CD19 Activity in B Cells Contributes to Immunodeficiency in Mice Deficient in the ICF Syndrome Gene Zbtb24

[Cellular & Molecular Immunology] Investigators showed that mice deficient in Zbtb24 in the hematopoietic lineage recapitulated the major clinical features of patients with immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome.

CTRP4/Interleukin-6 Receptor Signaling Ameliorates Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation

[Journal of Clinical Investigation] Researchers demonstrated that Th17 cell-associated experimental autoimmune encephalomyelitis was greatly exacerbated in C1q/TNF related protein 4 (CTRP4)-/- mice compared to WT mice due to increased Th17 cell infiltration.

Engineered IL-7 Synergizes with IL-12 Immunotherapy to Prevent T Cell Exhaustion and Promote Memory without Exacerbating Toxicity

[Science Advances] Scientists showed that the combination of engineered, tumor matrix-binding IL-7 and IL-12 achieves remarkable anticancer effects by activating complementary pathways without inducing any additive immunotoxicity.

Unrestrained Cleavage of Roquin-1 by MALT1 Induces Spontaneous T Cell Activation and the Development of Autoimmunity

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that autoimmunity, caused by conventional T cells expressing constitutively active MALT1 paracaspase, was triggered by cleavage of a single substrate, the RNA-binding protein Roquin-1.

Ginseng-Derived Nanoparticles Reprogram Macrophages to Regulate Arginase-1 Release for Ameliorating T Cell Exhaustion in Tumor Microenvironment

[Journal of Experimental & Clinical Cancer Research] By regulating the mTOR-T-bet axis, ginseng-derived nanoparticles reprogramed macrophages to regulate arginase-1 release, which further ameliorated T cell exhaustion in tumor microenvironment.

MDSCs-Derived GPR84 Induces CD8+ T Cell Senescence via p53 Activation to Suppress the Antitumor Response

[Journal for Immunotherapy of Cancer] Scientists showed that the transfer of G-protein-coupled receptor 84 (GPR84) from myeloid-derived suppressor cells (MDSCs) to CD8+ T cells via the exosomes attenuated the antitumor response.

PD-1 Inhibits T Cell Actin Remodeling at the Immunological Synapse Independently of Its Signaling Motifs

[Science Signaling] Researchers investigated the mechanisms underlying programmed cell death molecule 1 (PD-1)–mediated inhibition. Their findings suggest an alternative mechanism by which PD-1 regulated immune responses.

The USP7-STAT3-Granzyme-Par-1 Axis Regulates Allergic Inflammation by Promoting Differentiation of IL-5-Producing Th2 Cells

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors found that granzyme A- and B-producing Th2 cells played a key role in the promotion of pathogenic Th2 cells via protease-activated receptor (Par)-1 and induced the phosphorylation of p38 mitogen-activated protein kinase.

AIM/CD5L Ameliorates Autoimmune Arthritis by Promoting Removal of Inflammatory DAMPs at the Lesions

[Journal of Autoimmunity] Investigators showed that apoptosis inhibitor of macrophage (AIM) protein regulated arthritis by promoting removal of lesional danger-associated molecular patterns (DAMPs) both physiologically and therapeutically.

University of Bonn Receives Three ERC Consolidator Grants

[University of Bonn] Another big success for the University of Bonn in securing grants from the European Research Council (ERC), with three researchers receiving an ERC Consolidator Grant: Drs. Jan Hasenauer, Florian I. Schmidt, and Evgeny Shinder.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.