Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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IL-17A Deficiency in HLA-DR3 Transgenic Mice Enriches Beneficial Prevotella Species in Gut to Promote Tregs and Reduce CNS Autoimmunity

July 3, 2026

[Microbiome] Scientists redefined IL-17A's role in immune regulation, emphasizing its ability to directly influence gut microbiota composition and the abundance of Treg-promoting bacteria.

Orca Bio’s TREGZI™ Receives US FDA Approval as First and Only Precision-Engineered Cell Therapy for Allogeneic Transplant in Adults with Hematological Malignancies

July 3, 2026

[Orca Bio] Orca Bio announced the US FDA has approved TREGZI™, for use in matched-donor hematopoietic stem cell transplantation with myeloablative preparative regimen, for hematopoietic and immunologic reconstitution and to improve chronic graft-versus-host disease-free survival, in the treatment of adults with hematological malignancies.

Reactive Species As Regulators of Immune Cell Metabolism, Tolerance, and Autoimmunity

July 3, 2026

[Cell Metabolism] The authors describe how redox imbalance breaks tolerance in systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. They outline targeted strategies that alleviate redox imbalance in autoimmune pathologies.

Harnessing Regulatory T Cells to Modulate Acute Brain Injury: From Mechanisms to Therapy

July 3, 2026

[Molecular Neurobiology] Scientists examine the mechanistic roles of Tregs in modulating central nervous system (CNS)-resident cells such as microglia, astrocytes, and endothelial cells, with emphasis on their capacity to suppress inflammation and support functional recovery.

Transplantation Tolerance Versus Immune Evasion: Mechanistic Divergences and Therapeutic Frontiers for Islet Cell Replacement

July 3, 2026

[Cell Reports Medicine] Transplantation tolerance, a recipient-centric strategy, utilizes central deletional processes through mixed hematopoietic chimerism and thymic repertoire sculpting, complemented by peripheral mechanisms such as T cell anergy, exhaustion, apoptotic deletion, and Treg dominance.

Memory Regulatory T Cells Reprogram Into Protective TFH Cell-Like Effectors in Recurrent Malaria

July 3, 2026

[Nature Immunology] During a primary infection with Plasmodium, Treg cells suppress protective immunity by inhibiting germinal center reactions, thereby impeding the control of parasitemia.

IL-2 Mutein Promotes Antigen-Specific Transplant Acceptance in Mice through Expansion of ST2 Regulatory T Cells

July 3, 2026

[Nature Communications] Researchers investigated the therapeutic efficacy of an IL-2 mutein molecule with enhanced receptor specificity and extended half-life in murine models of solid organ transplantation.

CD4+CD25+ Regulatory T Cells Circumstantially Initiate Transplant Rejection through CXCL15/Neutrophil Axis

July 3, 2026

[Communications Biology] Scientists unexpectedly found that infusion of CD4+CD25+ Tregs plus IL-2 in lymphocyte-deficient mice causes skin and heart allograft rejection, while IL-2 or Treg alone didnot.

Genetically Modulating the RNA-Binding Protein Regnase-1 Reveals Its Critical Role in Regulatory T Cell Homeostasis and Function In Vivo

July 3, 2026

[Cell Death & Disease] Investigators generated a conditional knock-in strain in which a degradation-resistant Regnase-1 mutant (R111A) was selectively expressed in Foxp3+ Tregs as a transgene investigate the roles of Regnase-1 in Tregs.

FAM234A Acts As a Switch Between Th17 and Treg Cell Fate Decisions That Control Inflammatory Bowel Disease

July 3, 2026

[Cellular & Molecular Immunology] In a DSS-induced inflammatory bowel disease model in Rag2-/- mice with either naive WT or Fam234a-deficient CD4+ T cells, mice with Fam234a-deficient CD4+ T cells presented milder symptoms of colitis, accompanied by a decreased ratio of Th17/Treg cells.

Mechanobiology of Regulatory T Cells: How Cellular Mechanics Shape Immune Suppression

June 19, 2026

[npj Biological Physics and Mechanics] The authors propose that Treg efficiency is shaped by cellular mechanics—particularly membrane tension and actin organization—yielding a distinct biophysical signature for antigen-specific suppression.

CD45 As a Multifunctional Target in Immune Regulation and Therapeutic Delivery

June 19, 2026

[Journal of Translational Medicine] The authors summarize the immunoregulatory mechanisms of CD45 across various immune cell subsets and discusses CD45-based therapeutic interventions and drug delivery strategies, bridging basic immunology with therapeutic advancement.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.