Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Activation of the Transcription Factor NFAT5 in the Tumor Microenvironment Enforces CD8+ T Cell Exhaustion

[Nature Immunology] Researchers found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8+ T cells in the context of chronic infections and tumors but was selectively required in tumor-induced CD8M+ T cell exhaustion.

Antigen-Presenting Autoreactive B Cells Activate Regulatory T Cells and Suppress Autoimmune Arthritis in Mice

[Journal Of Experimental Medicine] Using unique tetramers, scientists traced natural autoreactive B cells specific for a defined triple-helical epitope on collagen type-II, constituting a sizeable fraction of the physiological B cell repertoire in mice, rats, and humans.

Single-Cell Immune Profiling of Mouse Liver Aging Reveals Cxcl2+ Macrophages Recruit Neutrophils to Aggravate Liver Injury

[Hepatology] Nine subsets of 89,542 immune cells with unique properties were identified, of which Cxcl2+ macrophages within the monocyte/macrophage subset were preferentially enriched in the aged liver.

Sterile Triggers Drive Joint Inflammation in TNF- and IL-1β-Dependent Mouse Arthritis Models

[EMBO Molecular Medicine] Using two independent transgenic mouse arthritis models, either TNF- or IL-1β dependent, investigators demonstrated that arthritis developed independently of the microbiota and intestinal inflammation.

A Genome-Wide In Vivo CRISPR Screen Identifies Essential Regulators of T Cell Migration to the CNS in a Multiple Sclerosis Model

[Nature Neuroscience] Scientists conducted a genome-wide in vivo CRISPR screen in a rat multiple sclerosis model and identified five essential brakes and 18 essential facilitators of T cell migration to the central nervous system.

Germinal Center Output Is Sustained by HELLS-Dependent DNA-Methylation-Maintenance in B Cells

[Nature Communications] Investigators showed by a newly generated B-cell-specific Hells conditional knockout mouse model that HELLS ((Helicase, Lymphoid Specific) played a pivotal role in T-dependent B cell responses.

Treg-Targeted IL-2/Anti-IL-2 Complex Controls Graft-Versus-Host Disease and Supports Anti-Tumor Effect in Allogeneic Hematopoietic Stem Cell Transplantation

[Haematologica] In dedicated experimental models of allogeneic hematopoietic stem cell transplantation the authors evaluated side-by-side the therapeutic effect of two IL-2/anti-IL-2 complexes designed either to boost Tregs, or alternatively to activate effector T cells Teffs, on GVHD occurrence and tumor relapse.

Distribution Modeling Quantifies Collective TH Cell Decision Circuits in Chronic Inflammation

[Science Advances] Investigators developed a general mathematical framework for the data-driven analysis of collective immune cell dynamics.

Slan+ Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis

[Cancer Immunology Research] Scientists showed that, after coculture with target cells coated with anti-CD20 or anti-CD38, slan+ monocytes mediated trogocytosis, a cell–cell contact dependent, antibody-mediated process that triggers an active, mechanic disruption of target cell membranes.

The Guanine Nucleotide Exchange Factor Rin-Like Controls Tfh Cell Differentiation via CD28 Signaling

[Journal Of Experimental Medicine] Loss of the guanine nucleotide exchange factor Rin-like led to an increase of Tfh in aging, upon in vivo immunization and acute LCMV Armstrong infection in mice, and in human CD4+ T cell in vitro cultures.

Multifaceted Control of T Cell Differentiation by STIM1

[Trends In Biochemical Sciences] Scientists focus on novel STIM (stromal interaction molecule)-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function.

TGF-β Signaling in Health and Disease

[Cell] The authors review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.