Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Phosphofructokinase P Fine-Tunes T Regulatory Cell Metabolism, Function, and Stability in Systemic Autoimmunity

[Science Advances] In Treg cells, a CRISPR-Cas9–enabled Pfkp deletion recapitulated the metabolism of Camk4−/− Treg cells, and improved their function and stability in vitro and in vivo.

BioNTech and Ryvu Therapeutics Enter into Global Collaboration to Develop and Commercialize Immuno-Modulatory Small Molecule Candidates

[BioNTech and Ryvu Therapeutics] The two companies have entered into a multi-target research collaboration for several small molecule immunotherapy programs as well as an exclusive license agreement for Ryvu’s STING agonist portfolio as standalone small molecules.

mTORC1 Links Pathology in Experimental Models of Still’s Disease and Macrophage Activation Syndrome

[Nature Communications] Single-cell RNA sequencing in a murine model of Still’s disease showed preferential activation of mechanistic target of rapamycin complex 1 (mTORC1) in monocytes; both mTOR inhibition and monocyte depletion attenuated disease severity.

Distinct Changes in Endosomal Composition Promote NLRP3 Inflammasome Activation

[Nature Immunology] Researchers demonstrated that NLR family pyrin domain containing protein 3 (NLRP3) inflammasome activators primarily converged on disruption of endoplasmic reticulum–endosome membrane contact sites (EECS).

GPSM1 Impairs Metabolic Homeostasis by Controlling a Pro-inflammatory Pathway in Macrophages

[Nature Communications] Mice with myeloid-specific G-protein-signaling modulator 1 (GPSM1) ablation were protected against high fat diet-induced insulin resistance, glucose dysregulation, and liver steatosis via repression of adipose tissue pro-inflammatory states.

The Influenza-Injured Lung Microenvironment Promotes MRSA Virulence, Contributing to Severe Secondary Bacterial Pneumonia

[Cell Reports] By conditioning Staphylococcus aureus (MRSA) ex vivo in bronchoalveolar lavage fluid collected from mice at various time points of influenza infection, investigators found that the influenza-injured lung microenvironment dynamically induced MRSA to increase cytotoxin expression, while decreasing metabolic pathways.

Antigen-Presenting T Cells Provide Critical B7 Co-stimulation for Thymic iNKT Cell Development via CD28-Dependent Trogocytosis

[Cell Reports] Mechanistically, antigen-presenting T cells provided co-stimulation through an unconventional mechanism, acquiring B7 molecules via CD28-dependent trogocytosis from B7-expressing thymic epithelial cells, dendritic cells, and B cells, and providing critical B7 co-stimulation to developing iNKT cells.

STAT3 Gain-of-Function Mutations Connect Leukemia With Autoimmune Disease by Pathological NKG2Dhi CD8+ T Cell Dysregulation and Accumulation

[Immunity] The authors analyzed patients and mice with germline STAT3 gain-of-function (GOF) mutations, and found that these mutations drove the accumulation of effector CD8+ T cell clones highly expressing NKG2D, the receptor for stress-induced MHC-class-I-related molecules.

Identification of aceNKPs, a Committed Common Progenitor Population of the ILC1 and NK Cell Continuum

[Proceedings of the National Academy of Sciences of the United States of America] Using novel polychromic mice to achieve higher phenotypic resolution, scientists have characterized bone marrow progenitors that were committed to the group 1 ILC lineage.

Early T-Bet Promotes LFA1 Upregulation Required for CD8+ Effector and Memory T Cell Development

[Journal of Experimental Medicine] Researchers showed that, following vaccination with a replication-deficient strain of Toxoplasma gondii, CD8+ T cell expression of T-bet was required for optimal expansion of parasite-specific effector CD8+ T cells.

The Lysosomal Ragulator Complex Activates NLRP3 Inflammasome In Vivo via HDAC6

[EMBO Journal] Deficiency of Lamtor1, an essential component of the Ragulator complex, abrogated NLRP3 inflammasome activation in murine macrophages and human monocytic cells.

Lupus Foundation of America Announces Recipients of the Gary S. Gilkeson Career Development Award

[Lupus Foundation of America] The Gary S. Gilkeson Career Development Award was designed for fellows and clinicians with the goal of supporting early career scientists and providing mentorship during a critical time in their lupus research career.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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