Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Anti-PD-1 Therapy Triggers Tfh Cell–Dependent IL-4 Release to Boost CD8 T Cell Responses in Tumor-Draining Lymph Nodes

[Journal Of Experimental Medicine] Researchers showed that anti-PD-1 monoclonal antibody enhanced CD8+ T cell responses in tumor-draining lymph nodes by stimulating cytokine production in follicular helper T cells.

RUNX1 Promotes Angiogenesis in Colorectal Cancer by Regulating the Crosstalk between Tumor Cells and Tumor Associated Macrophages

[Biomarker Research] Scientists investigated the RUNX1 mediated crosstalk between tumor cells and M2 polarized tumor associated macrophages (TAMs) in colorectal cancer, as well as its relationship with neoplastic angiogenesis.

Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes

[Circulation Research] High-throughput RNA sequencing was performed using human monocyte samples from controls and diabetes.

Suppression of the METTL3-m6A-Integrin β1 Axis by Extracellular Acidification Impairs T Cell Infiltration and Antitumor Activity

[Cell Reports] Mechanistically, extracellular acidification significantly impedeD T cell motility by suppressing podosome formation.

Modulating Tumoral Exosomes and Fibroblast Phenotype Using Nanoliposomes Augments Cancer Immunotherapy

[Science Advances] Researchers showed that cancer cell–targeted nanoliposomes that inhibited sequential steps of exosome biogenesis and released from lung cancer cells block the differentiation of lung fibroblasts into cancer associated fibroblasts.

Integrating Single-Cell Multi-Omics and Prior Biological Knowledge for a Functional Characterization of the Immune System

[Nature Immunology] The authors review how the integration of single-cell and spatial multi-omics data with prior knowledge allows us to obtain functional insights, focusing on gene regulatory processes and cell–cell interactions.

MD Anderson Tried — and Failed — to Resolve Research Credit Dispute between Two Scientists, New Documents Show

[STAT News] Early last year, MD Anderson Cancer Center leadership had a contentious dispute between one of its most powerful researchers and a junior scientist over authorship, credit, and charges of verbal abuse. High-ranking officials at the cancer center tried — and failed — to resolve the feud.

Generation of Tolerogenic Dendritic Cells under the Persistent Inflammation Stimulation

[Shock] Researchers generated tolerogenic dendritic cells by exposing them to sublethal lipopolysaccharide for 72 hours while preserving cell viability.

IL-37 Dampens Immunosuppressive Functions of MDSCs via Metabolic Reprogramming in the Tumor Microenvironment

[Cell Reports] The authors established a human leukocyte antigen-I-matched humanized patient-derived xenograft hepatocellular carcinoma (HCC) model and three murine orthotopic HCC models to study the function of IL-37 in the tumor microenvironment.

Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells

[ACS Nano] The authors engineered artificial antigen presenting cells with optimized size, stiffness and activation signals to induce human and mouse CD8+ T memory stem cells in vitro.

Redox Regulation of m6A Methyltransferase METTL3 in β-Cells Controls the Innate Immune Response in Type 1 Diabetes

[Nature Cell Biology] Scientists reported that N6-methyladenosine (m6) was an adaptive β-cell safeguard mechanism that controlled the amplitude and duration of the antiviral innate immune response at type 1 diabetes onset.

The ATR Inhibitor Ceralasertib Potentiates Cancer Checkpoint Immunotherapy by Regulating the Tumor Microenvironment

[Nature Communications] Researchers showed that modeling of intermittent ceralasertib treatment in mouse tumor models revealed CD8+ T-cell dependent antitumor activity, which was separate from the effects on tumor cells.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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