Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Cancer Cells Dying from Ferroptosis Impede Dendritic Cell-Mediated Anti-Tumor Immunity

[Nature Communications] The authors presented an inducible model of ferroptosis, distinguishing three phases in the process — ‘initial’ associated with lipid peroxidation, ‘intermediate’ correlated with ATP release, and ‘terminal’ recognized by HMGB1 release and loss of plasma membrane integrity — that serves as tool to study immune cell responses to ferroptotic cancer cells.

Tissue-Resident Memory CD8+ T Cells Possess Unique Transcriptional, Epigenetic and Functional Adaptations to Different Tissue Environments

[Nature Immunology] The diversity of gene expression and genome accessibility by mouse CD8+ tissue-resident memory T cells from distinct organs that responded to viral infection revealed both shared and tissue-specific transcriptional and epigenetic signatures.

Harnessing Anti-Cytomegalovirus Immunity for Local Immunotherapy against Solid Tumors

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated whether intratumoral injection of virus-derived peptide epitopes could activate preexisting antiviral T cell responses locally and promote antitumor responses or antigen spreading.

Differential IL-12 Signaling Induces Human Natural Killer Cell Activating Receptor-Mediated Ligand-Specific Expansion

[Journal of Experimental Medicine] Scientists showed that IL-12 alone could sustain human primary NK cell survival without providing IL-2 or IL-15 but was insufficient to promote human NK cell proliferation.

KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer

[Cancer Immunology Research] Scientists demonstrated that a lysine 4 histone H3 demethylase (KDM5A) impaired epithelial ovarian cancer infiltration by immune cells and inhibited antitumor immune responses.

Glucocorticoid Signaling and Regulatory T Cells Cooperate to Maintain the Hair-Follicle Stem-Cell Niche

[Nature Immunology] By using hair follicles (HFs) to study Treg cell–stem cell crosstalk, the authors showed an unrecognized function of the steroid hormone glucocorticoid in instructing skin-resident Treg cells to facilitate HF stem-cell activation and HF regeneration.

Chimeric Adenoviral (Ad5.F35) and Listeria Vector Prime-Boost Immunization Is Safe and Effective for Cancer Immunotherapy

[NPJ Vaccines] Researchers examined a prime-boost strategy using a chimeric adenoviral vector that resisted pre-existing immunity followed by recombinant Listeria monocytogenes to amplify immunity to the gastrointestinal cancer antigen GUCY2C.

Therapeutic Inhibition of the SRC-Kinase HCK Facilitates T Cell Tumor Infiltration and Improves Response to Immunotherapy

[Science Advances] The authors demonstrated that genetic ablation or therapeutic inhibition of the myeloid-specific hematopoietic cell kinase enabled activity of antagonistic anti–programmed cell death protein 1, anti-CTLA4, or agonistic anti-CD40 immunotherapies in otherwise refractory tumors and augments response in treatment-susceptible tumors.

Signaling Mechanisms and Cellular Functions of SUMO

[Nature Reviews Molecular Cell Biology] Recent progress has increased our understanding of the cellular and pathophysiological roles of small ubiquitin-like modifiers (SUMO) modifications, extending their functions to the regulation of immunity, pluripotency, and nuclear body assembly in response to oxidative stress.

Arming a Killer: Mitochondrial Regulation of CD8+ T Cell Cytotoxicity

[Trends in Cell Biology] Investigators review the multifaceted roles of mitochondria during T cell differentiation, focusing on CD8+ cytotoxic T lymphocytes (CTLs) and consider how mitochondrial dysfunction can contribute to CTL exhaustion.

Appetite for Allergies: Alladapt Banks $119M to Push Immunotherapy through Trials

[Fierce Biotech] Alladapt Immunotherapeutics has refilled the bank balance with $119 million in institutional financing from the likes of Novartis, which will be used to follow the biotech's dream of developing the first FDA-approved therapy to treat the majority of food allergy patients.

Mustang Bio Announces Orphan Drug Designation Granted to MB-106, a CD20-targeted, Autologous CAR T Cell Therapy for the Treatment of Waldenstrom Macroglobulinemia

[Mustang Bio, Inc.] Mustang Bio, Inc. announced that the US FDA has granted Orphan Drug Designation to MB-106, Mustang’s CD20-targeted, autologous CAR T cell therapy for the treatment of Waldenstrom macroglobulinemia, a rare type of B-cell non-Hodgkin lymphoma.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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