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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
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Complement C5a Fosters Tumor-Promoting Immunity by Recruiting Regulatory T Cells in Hepatocellular Carcinoma
[Cancer Letters] Investigators utilized CRISPR/Cas9 technology to knock out complements proteins C3 or C5 in mouse liver cancer cells. They demonstrated that C5ar1 knockout significantly reduced the infiltration of Tregs and M2-like tumor-associated macrophages into the tumor immune microenvironment.
Metabolic Sensor AMPK Licenses Intestinal CD103 DCs to Induce T Responses
[Science Advances] Researchers characterized the metabolic properties of intestinal conventional dendritic cells (DCs) and defined the role of AMP-activated kinase (AMPK) signaling in their differentiation and ability to induce Tregs.
Intercalated Cells Contribute to the Immune Responses in Renal Autoimmune Disease
[Journal of Autoimmunity] To investigate the molecular mechanisms by which intercalated cells crosstalk with immune cells during autoimmune kidney injury, scientists depleted Foxp3+ Tregs by injecting diphtheria toxin into male and female Foxp3-DTR mice.
Optimizing CRISPR-Cas9-Mediated TCR Knockout in Primary Mouse CD8+, CD4+, and Regulatory T Cells
[Scientific Reports] Researchers presented an optimized CRISPR–Cas9 RNP-based genome editing pipeline for T cells, beginning with human Jurkat cells and extending to primary mouse CD4⁺, CD8⁺, and Tregs. They demonstrated efficient Trac editing in primary mouse Tregs, reaching up to 85% knockout.
Regulatory T Cells As Drivers of CNS Remyelination: Neuro-Immune Cross-Talk and Comparative Insights from Mammalian and Zebrafish Models
[International Reviews of Immunology] Recent research shows that Tregs affect oligodendrocyte lineage progression, microglial and astrocytic responses, and the milieu around the demyelination site in order to perform remyelination.
Mechanistic Study of IL-17 Inhibitors in Alleviating Inflammation in Ankylosing Spondylitis by Regulating Treg Cell Function through Modulation of the Ahr Signaling Pathway
[Human Cell] Scientists explored whether IL-17 inhibitors alleviate inflammation in ankylosing spondylitis by modulating the aryl hydrocarbon receptor (Ahr) signaling pathway to influence Treg function.
A Tolerogenic mRNA-LNP Vaccine Alleviates Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis
[Science Bulletin] The authors developed a candidate tolerogenic messenger RNA-lipid nanoparticle vaccine for Multiple Sclerosis (MS) encoding a tandem fusion of epitopes derived from three MS-associated myelin antigens.
GentiBio Secures NIH Backing for Allogeneic Engineered Treg Therapy in Type 1 Diabetes
[GentiBio, Inc. (AllSci)] GentiBio, Inc. has received a USD 1.07 million NIH Phase II grant from the National Institute of Diabetes and Digestive and Kidney Diseases to advance an allogeneic, off-the-shelf engineered Treg therapy for newly diagnosed type 1 diabetes. q
CD4+CD25+FOXP3+ Regulatory T Cells to Protect against Graft-Versus-Host Disease
[Blood] The authors discuss the history, preclinical studies, and successful translation of CD4+CD25+FoxP3+ Tregs in the context of allogeneic hematopoietic cell transplantation.
UV Irradiation Drives Lineage-Specific MITF-Mediated Transcription of PD-L1 to Confer Immune Tolerance to UV-Mutated Melanocytes
[Immunity] Researchers investigated whether melanocyte-intrinsic transcriptional program(s) underlie immune tolerance to mutations resulting from UV radiation exposure.
Defined Human Clostridia Consortia Reverse Colitis via Dual Effects of Tryptophan Metabolites on Microbiota and Immunity
[Cell Host & Microbe] The authors investigated the therapeutic efficacy of two live biotherapeutic products, human Clostridia consortia 17-mix and 11-mix, by treating established colitis in murine models. Both LBPs exhibited therapeutic effects in T cell-mediated chronic colitis models induced by human microbiota and in pathobiont-driven gnotobiotic colitis models.
The SLC15A4-TASL Complex Is Essential for Lupus Development in Mice
[Proceedings of the National Academy of Sciences of the United States of America] Using three complementary mouse models reflecting distinct causes of lupus-like disease, scientists show that disruption of the SLC15A4–TASL complex broadly prevents autoimmunity, including immune activation, pathogenic B cell responses, and autoantibody production.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
