Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Particulate Matter 10 Exposure Affects Intestinal Functionality in Both Inflamed 2D Intestinal Epithelial Cell and 3D Intestinal Organoid Models

[Frontiers In Immunology] The authors established chronically inflamed intestinal epithelium models utilizing two-dimensional (2D) human intestinal epithelial cells and 3D human intestinal organoids in order to examine the deleterious effects of particulate matter (PM) 10 in human intestine-like in vitro models.

Council Calls for Transparent, Equitable, and Open Access to Scholarly Publications

[Council of the European Union] The Council has adopted conclusions on the ‘high quality, transparent, open, trustworthy and equitable scholarly publishing’, in which it calls for immediate and unrestricted open access in publishing research involving public funds.

Thousands of Early-Career NIH Researchers Forming Union for First Time

[Nature News] Thousands of early-career researchers at the US National Institutes of Health (NIH) have kick-started the process of forming a union. They are calling on the agency — the world’s largest biomedical funder — to raise pay and improve benefits, as well as to bolster its policies and procedures on harassment and excessive workloads.

Divergent Metabolic Programmes Control Two Populations of MAIT Cells That Protect the Lung

[Nature Cell Biology] Following pulmonary immunization with a Salmonella vaccine strain, mouse MAIT cells expanded as separate CD127Klrg1+ and CD127+Klrg1 antigen-adapted populations that differed in terms of their transcriptome, function and localization in lung tissue.

Spatial Dysregulation of T Follicular Helper Cells Impairs Vaccine Responses in Aging

[Nature Immunology] Scientists showed that T follicular helper (TFH) cell localization was critical for the quality of the antibody response and for the expansion of the follicular dendritic cell network upon immunization.

Monocyte-Derived IL-6 Programs Microglia to Rebuild Damaged Brain Vasculature

[Nature Immunology] Cerebrovascular repair did not occur in interluekin (IL)-6 knockouts or in mice lacking microglial IL-6Ra expression, and single-cell transcriptomic analyses revealed faulty repair-associated microglia programming in the absence of IL-6 signaling.

Quantitative Control of Ets1 Dosage by a Multi-Enhancer Hub Promotes Th1 Cell Differentiation and Protects from Allergic Inflammation

[Immunity] Mathematical modeling identified a highly connected multi-enhancer hub at the Ets1 locus, comprising a noncoding regulatory element that was a hotspot for sequence variation associated with allergic disease in humans.

Mettl3-m6A-Creb1 Forms an Intrinsic Regulatory Axis in Maintaining iNKT Cell Pool and Functional Differentiation

[Cell Reports] Conditional ablation of Mettl3 in CD4+CD8+ double-positive thymocytes impaired invariant natural killer T cell proliferation, differentiation, and cytokine secretion.

PD-L1 Checkpoint Blockade Promotes Regulatory T Cell Activity That Underlies Therapy Resistance

[Science Immunology] Researchers identified preferential activation and enhanced suppressive capacity of regulatory T cells in αPD-L1 therapy–resistant solid tumor–bearing mice.

Adoptive Treg Therapy with Metabolic Intervention via Perforated Microneedles Ameliorates Psoriasis Syndrome

[Science Advances] Treg cells administered through perforated microneedle substantially ameliorated psoriasis syndrome with the assistance of fatty acid–mediated metabolic intervention in a psoriasis mouse model.

Ovol1/2 Loss-Induced Epidermal Defects Elicit Skin Immune Activation and Alter Global Metabolism

[EMBO Reports] The authors demonstrated that inducible and simultaneous ablation of transcription factor-encoding Ovol1 and Ovol2 in adult epidermis results in barrier dysregulation through impacting epithelial-mesenchymal plasticity and inflammatory gene expression.

Steroid Receptor Coactivator 3 Is a Key Modulator of Regulatory T Cell–Mediated Tumor Evasion

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Using an aggressive E0771 mouse breast cell line syngeneic immune-intact murine model, scientists observed that breast tumors were “permanently eradicated” in a genetically engineered tamoxifen-inducible Treg-cell-specific SRC-3 knockout female mouse that did not possess a systemic autoimmune pathological phenotype.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.