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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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Direct Relief and the Pfizer Foundation Announce New Grantees in Fifth Year of Infectious Disease Program
[Direct Relief] Direct Relief and The Pfizer Foundation announced the third cohort of the Innovation Awards in Community Health, supporting infectious disease prevention and management in underserved communities.
Consolidator Grant Supports Long-Term Research on Brain Infections
[Karolinska Institutet] Federico Iovino has been awarded a five-year consolidator grant from Karolinska Institutet for his research on bacterial infections that affect the brain. The funding will enable long-term planning in studies of conditions such as meningitis and encephalitis.
Maternal Helminths Rewire the Microbiota to Promote Offspring Antiviral Immunity
[Cell Host & Microbe] Researchers discovered that maternal helminths, an evolutionarily conserved mammalian partner lost in industrialized societies, confer broad and lasting protection against respiratory viruses in offspring. Analysis of chronically helminth-infected human populations reveals gut microbiota enriched for tryptophan metabolic capacity.
Affinity-Matured B Cell Responses Neutralizing Type-I Interferons Underlie Severe Viral Infections
[Cell] Researchers reported that autoantibodies neutralizing type-I interferon-positive patients with life-threatening COVID-19 pneumonia harbor circulating type-I IFN-specific B cells indistinguishable from patients bearing T cell tolerance defects of genetic origin.
MELK Inhibition Disrupts Actin Cytoskeleton and Broadly Restricts Human Coronavirus Infections
[Nature Communications] Investigators identified maternal embryonic leucine zipper kinase (MELK) as a common kinase required for the infections of multiple human coronaviruses currently circulating in the population. Inhibition of MELK activity by OTSSP167 exhibits broad antiviral effects in human airway organoids as well as in mice under a prophylactic setting.
HIV-1 Signaling Remodels Nuclear Pores to License Infection
[Nature] Investigators showed that HIV-1 capsid nuclear import at the nuclear pore complex (NPC) is a bottleneck to resting T cell infection, but that HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to drive nuclear import and licence infection.
Human Sand Fly Challenge Elicits Saliva-Specific Innate and Type 1-Polarized Immunity That Promotes Leishmania Killing
[Communications Biology] Scientists identified two Lu. longipalpis salivary proteins, LJM19 and LJL143, which elicit type 1 cytokine responses in cells from exposed individuals and which correlate with enhanced killing of Leishmania parasites in co-cultured macrophages.
NV-387 for The Treatment of Measles is Granted Orphan Drug Designation by The US FDA
[NanoViricides, Inc. (BioSpace)] NanoViricides, Inc. announced that its clinical stage, broad-spectrum, antiviral drug NV-387 has been granted an Orphan Drug Designation by the US FDA. NV-387 is the only drug candidate that has demonstrated strong in vivo activity against lethal infection with the Measles virus in a humanized animal model study.
Tissue Reservoirs of HIV: The Hidden Protective Role of Lymphoid and Myeloid Cells
[Reviews in Medical Virology] The authors analyzed the body's primary systems that serve as safe harbour sites for human Immunodeficiency Virus (HIV), including the monocyte/macrophage, lymphatic system, nervous system, respiratory system, reproductive system, and urinary system.
The Expanding Organ Tropism of Herpes Simplex Virus Type 1
[Reviews in Medical Virology] Scientists discuss current findings linking Herpes simplex virus type 1 (HSV-1) to a broad spectrum of organs, including the heart, lungs, intestines, and liver, as well as several clinical effects and diseases, which demand an in-depth analysis of HSV-1 pathogenesis with a critical focus on its pressing clinical implications.
An Ad5-Vectored Platform Generating Self-Assembling VLPs Elicits Potent Mucosal Immunity against Influenza a Virus and SARS-CoV-2
[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed Ad5-Envp- virus-like particles (VLP,) a chimeric adenoviral platform enabling spontaneous in vivo assembly of envelope protein-displaying VLPs using advanced technology. Intranasal administration of a single-dose Ad5-HA-VLP confers long-lasting protection against influenza A strains.
Vaccination Generates Broadly Cross-Neutralizing Antibodies to the HIV Env Apex
[Nature] Investigators identified a vaccination strategy using heterologous HIV envelope glycoprotein trimers covalently coupled to liposomes for multivalent display that resulted in the elicitation of cross-neutralizing HIV serum antibody responses in all trimer-liposome-immunized non-human primates.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
