Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Gradient to Sectioning CUBE Workflow for the Generation and Imaging of Organoids with Localized Differentiation

[Communications Biology] Researchers presented a workflow for culturing organoids with morphogen gradient using a CUBE culture device, followed by sectioning samples with the CUBE to retain information on gradient direction.

Acute Liver Steatosis Translationally Controls the Epigenetic Regulator MIER1 to Promote Liver Regeneration in a Study with Male Mice

[Nature Communications] Physiologically, liver acute lipid accumulation induced the phosphorylation of eukaryotic translation initiation factor 2, which consequently attenuated Mier1 translation. MIER1 downregulation in turn promoted cell cycle gene expression and regeneration through chromatin remodeling.

Generation of Hypothalamic Neural Stem Cell-Like Cells In Vitro from Human Pluripotent Stem Cells

[Stem Cell Reports] Scientists differentiated retina and anterior neural fold homeobox(RAX)::VENUS knockin hESCs into hypothalamic organoids and sorted RAX+ cells from mature organoids. The isolated RAX+ cells formed neurospheres and exhibited self-renewal and multipotency.

Generation of Functional Thymic Organoids From Human Pluripotent Stem Cells

[Stem Cell Reports] Researchers showed the generation of thymic epithelial cells in vitro in isogenic stem cell-derived thymic organoids, consisting of thymic epithelial progenitors, hematopoietic progenitor cells, and mesenchymal cells, differentiated from the same hPSC line.

O2 Variant Chip to Simulate Site-Specific Skeletogenesis from Hypoxic Bone Marrow

[Science Advances] Scientists cultured bone marrow mesenchymal stem cells in a 3D chip and implanted them into rabbit defect models of low-oxygen cartilage and high-oxygen calvaria bone in order to simulate site-specific skeletogenesis from hypoxic bone marrow.

Potent Antitumor Activity of Ensartinib in MET Exon 14 Skipping-Mutated Non-Small Cell Lung Cancer

[Cancer Letters] Molecular simulation was conducted to evaluate ensartinib c-MET interaction, and cell lines, patient-derived organoids, and xenograft models were used to test the effectiveness of ensartinib.

Oxypalmatine Regulates Proliferation and Apoptosis of Breast Cancer Cells by Inhibiting PI3K/AKT Signaling and Its Efficacy Against Breast Cancer Organoids

[Phytomedicine] Patient-derived organoid models were constructed to assess the therapeutic efficiency of Oxypalmatine in breast cancer.

Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids

[Molecular Pharmaceutics] Researchers used airway organoids to screen a chemical library of autophagic modulators to identify compounds that could potentially be used to fight against infections by a broad range of coronaviruses.

Advances in In Vitro Models of Neuromuscular Junction: Focusing on Organ-on-a-Chip, Organoids, and Biohybrid Robotics

[Advanced Materials] The authors review recent developments in in vitro neuromuscular junction (NMJ) models with 2D or 3D cultures, from organ-on-a-chip and organoids, to biohybrid robotics. They also introduce related derivative techniques for functional analysis of the NMJ.

NSW Government Backs University-Led Consortium on Drug Discovery

[The University of Sydney] The University of Sydney will lead the establishment of the NSW Organoid Innovation Centre, a new multi-institution facility that will apply the latest stem-cell techniques to accelerate drug discovery and design.

Light-Stimulated Insulin Secretion from Pancreatic Islet-Like Organoids Derived from Human Pluripotent Stem Cells

[Molecular Therapy] Investigators reported a novel optogenetic regulatory system for insulin secretion in human pluripotent stem cell-derived pancreatic islet-like organoids using monster-opto-Stromal interaction molecule 1.

Synthetic Enforcement of STING Signaling in Cancer Cells Appropriates the Immune Microenvironment for Checkpoint Inhibitor Therapy

[Science Advances] Scientists found in human and murine colorectal cancer (CRC) models that the superior antitumor immune response of mismatch repair–deficient CRC required tumor cell–intrinsic activation of cGAS-STING signaling triggered by genomic instability.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.