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Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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Pathways of Epithelial Barrier Breakdown and Remodeling in Esophageal Organoids by Commonly Used Surfactants
[Allergy] The authors investigated the molecular and functional consequences of sodium dodecyl sulfate and cocamidopropyl betaine exposure in primary eosinophilic esophagitis-derived esophageal organoids and air-liquid interface cultures derived from biopsy tissue samples.
Human iPSC-Derived Vascularised Lung Organoids for Modeling COPD and Pulmonary Hypertension
[Cell Proliferation] Using patient-derived vascularised lung organoid, scientists demonstrated that cigarette smoke extract induces pathological features resembling clinical chronic obstructive pulmonary disease, including epithelial disruption and inflammatory responses.
A Single-Organoid Workflow for Quantitative Imaging Classification and Tracking (SWIFT)
[Communications Biology] Researchers developed SWIFT, Single-organoid Workflow for quantitative Imaging classiFication and Tracking, a fast and modular pipeline for quantitative, time-resolved organoid analysis from brightfield images.
Trastuzumab Treatment Is Associated with Ferroptosis-Related Alterations in HER2-Positive Breast Cancer Organoids
[Cancer Chemotherapy and Pharmacology] Patient-derived breast cancer organoids were used to examine trastuzumab-associated ferroptosis-related changes and the possible involvement of p53 signaling.
Organoid Intelligence: A Promising Paradigm for Autism Spectrum Disorder Research
[Molecular Psychiatry] The authors highlight the integration of brain organoids and AI as an emerging “organoid intelligence” approach to uncover autism biology and advance personalized therapeutic discovery.
Greenstone Biosciences Awarded Breakthrough T1D Grant to Advance Islet Cell Platform
[Greenstone Biosciences (Business Wire)] Greenstone Biosciences has been awarded a Breakthrough T1D Industry Discovery and Development Partnership grant to develop a T1D-derived islet cell platform aimed at understanding and protecting insulin-producing β cells in people with type 1 diabetes.
Human Brain Organoids Record the Passage of Time over Multiple Years
[Nature] Investigators developed human brain organoids for 5 years in culture, optimizing growth conditions to extend excitatory neuron viability beyond previous limits.
Dual-Oxygen Pancreatic Cancer Organoids Recapitulate Basal-Classical Heterogeneity Validated by Spatial Transcriptomics
[British Journal of Cancer] Researchers showed that dual-oxygen pancreatic cancer organoids better capture basal–classical tumor heterogeneity, with hypoxia preserving aggressive basal-like cell states found in patient tumors.
Temporal Uncoupling of Radial Glia Lineage Progression in Cortical Organoids
[Nature] Scientists established mosaic analysis with double markers technology in mouse embryonic stem cells to probe radial glial progenitor lineage progression in a self-organizing cortical organoid system.
Elongating Human Heart Organoids Recapitulate Early Cardiac Morphogenesis and Axial Organization
[Developmental Cell] The authors generated elongating heart organoids from hiPSCs that undergo coordinated elongation and looping-like curvature, resembling early cardiac morphogenesis.
Screening Cross-Injury Responses in Skin Organoids Identifies a THBS2-Enriched Pro-Repair Fibroblast State during Regeneration
[Journal of Advanced Research] Researchers established a high-fidelity mouse skin organoid platform to simulate clinically relevant stressors and identify the core regulatory components of the regenerative program.
A Tonsil Organoid Model Reveals Epstein-Barr Virus-Infected Germinal Center B Cell States during Primary Infection
[Proceedings of the National Academy of Sciences of the United States of America] Investigators developed an Epstein–Barr virus human tonsil organoid model to evaluate key B cell states and antiviral responses, including after primary infection.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
