Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Germline PTEN Genotype-Dependent Phenotypic Divergence During the Early Neural Developmental Process of Forebrain Organoids

[Molecular Psychiatry] Investigators showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.

Temporal Morphogen Gradient-Driven Neural Induction Shapes Single Expanded Neuroepithelium Brain Organoids with Enhanced Cortical Identity

[Nature Communications] Scientists showed that initiating neural induction in a temporal stepwise gradient guided the generation of brain organoids composed of a single, self-organized apical-out neuroepithelium.

Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects

[Cell] The authors established a human cardioid platform that recapitulated the development of all major embryonic heart compartments, including right and left ventricles, atria, outflow tract, and atrioventricular canal.

Neurodevelopmental Defects in Human Cortical Organoids with N-Acetylneuraminic Acid Synthase Mutation

[Science Advances] Scientists found that N-acetylneuraminic acid synthase mutation resulted in the absence of both sialic acid and protein polysialylation in the cortical organoids and notably reduced the proliferation and expansion of neural progenitors.

Intestinal Paneth Cell Differentiation Relies on Asymmetric Regulation of Wnt Signaling by Daam1/2

[Science Advances] Researchers reported that the Dishevelled-associated activator of morphogenesis 1 (Daam1) and its paralogue Daam2 asymmetrically regulated canonical and noncanonical Wnt signaling.

Joint Epigenome Profiling Reveals Cell-Type-Specific Gene Regulatory Programmes in Human Cortical Organoids

[Nature Cell Biology] The authors combined a 3D genome, RNA, accessibility and methylation sequencing method with immunoFACS and RNA sequencing in cortical organoids to map the cell-type-specific regulatory landscape of human neural development across multiple epigenetic layers.

Detecting Host Responses to Microbial Stimulation Using Primary Epithelial Organoids

[Gut Microbes] Investigators derived organoids from the small intestine from a cohort of healthy individuals. Culturing intestinal epithelium on a flat laminin matrix induced their differentiation, facilitating analysis of microbial responses via the apical membrane normally exposed to the luminal content.

NOTCH3 Signaling Controls Human Trophoblast Stem Cell Expansion and Differentiation

[Development] Using trophoblast stem cells, trophoblast organoids, and primary cytotrophoblasts of early pregnancy, scientists showed that autocrine NOTCH3 signaling controlled human placental expansion and differentiation.

As Scientists Face a Flood of Papers, AI Developers Aim to Help

[Science] Artificial intelligence tools promise to help researchers digest scholarly literature in new ways, but technical and legal barriers may hinder widespread use.

Cancer Organoid-Based Diagnosis Reactivity Prediction (CODRP) Index-Based Anticancer Drug Sensitivity Test in ALK-Rearrangement Positive Non-Small Cell Lung Cancer (NSCLC)

[Journal Of Experimental & Clinical Cancer Research] A drug sensitivity test was performed using patient-derived organoids from the patient tissue and the primary cancer characteristics of pateint-derived organoids were confirmed by pathological comparision with tissue slides.

Inhaled Pulmonary Surfactant Biomimetic Liposomes for Reversing Idiopathic Pulmonary Fibrosis through Synergistic Therapeutic Strategy

[Biomaterials] Inspired by the successful application of pulmonary surfactant (PS) replacement therapy in lung disease treatment, the authors developed PS nano-biomimetic liposomes to utilize its natural transport pathway for targeting AECs while reducing lung tissue clearance.

Deriving Early Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

[Stem Cell Reports] Investigators developed a human brain organoid technique that generated self-organizing, single-rosette cortical organoids with reproducible size and structure at early timepoints.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.