Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Microglial Over-Pruning of Synapses during Development in Autism-Associated SCN2A-Deficient Mice and Human Cerebral Organoids

[Molecular Psychiatry] Scientists reported that Scn2a-deficient mice had impaired learning and memory, accompanied by reduced synaptic transmission and lower spine density in neurons of the hippocampus.

Electroacoustic Responsive Cochlea-on-a-Chip

[Advanced Materials] Scientists presented a novel cochlear organoids integrated conductive hydrogel biohybrid system with cochlear implant electroacoustic stimulation for cochlea-on-a-chip construction and high-throughput drug screening.

Bioengineering Toolkits for Potentiating Organoid Therapeutics

[Advanced Drug Delivery Reviews] Researchers described engineering strategies and alternative biocompatible materials that could facilitate the practical applications of organoids in regenerative medicine.

Activation of the PI3K/AKT Signaling Pathway by ARNTL2 Enhances Cellular Glycolysis and Sensitizes Pancreatic Adenocarcinoma to Erlotinib

[Molecular Cancer] Investigators examined the levels of various cancer hallmarks and identified glycolysis as the primary risk factor for overall survival in pancreatic cancer.

Neuropathogenesis-on-Chips for Neurodegenerative Diseases

[Nature Communications] The authors explore the interconnected pathogenic features of different types of neurodegenerative disease (ND), discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model.

New Canada Research Chairs Advance Research in Regenerative Medicine, Sustainable Housing, and More

[University of Toronto] New ways of growing human tissues outside the body, developed by Professor Alison McGuigan and her team, will help expand the ability of researchers to understand and control cell behavior.

Patient Derived Tumoroids of High Grade Neuroendocrine Neoplasms for More Personalized Therapies

Investigators established patient-derived tumoroids from biobanked tissue samples of advanced high-grade gastroenteropancreatic neuroendocrine neoplasms patients and applied this model for targeted rapid ex vivo...

We Should Be Open About Organoid Research to Avoid a Backlash

Research that involves creating "mini-organs" from human cells, including those from fetuses, may leave people uncomfortable – so the best approach is to explain...

Mass Spectrometry Imaging and Histology for the Analysis of Budding Intestinal Organoids

[Analytical Chemistry] Murine intestinal organoids were used to evaluate embedding in gelatin, carboxymethylcellulose (CMC)-gelatin-CMC-sucrose, or hydroxypropyl methylcellulose and polyvinylpyrrolidone solutions.

SOX17 Enables Immune Evasion of Early Colorectal Adenomas and Cancers

[Nature] Researchers investigated how naive colon cancer organoids that were engineered in vitro to harbour Apc-null, KrasG12D and Trp53-null (AKP) mutations adapted to the in vivo native colonic environment.

JAK/STAT3 Represents a Therapeutic Target for Colorectal Cancer Patients with Stromal-Rich Tumors

[Journal Of Experimental & Clinical Cancer Research] Scientists investigated the use of JAK inhibitors for anti-cancer activity in coloretal cancer cell lines, mouse model organoids and patient-derived organoids.

Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle-Shaped Microfluidic Device

[Advanced Healthcare Materials] After examining various dermal ECM molecules, investigators found that pluripotent stem cell-derived skin organoids generated in collagen type I supplemented with laminin 511 exhibited increased growth compared to conventional free-floating condition, but failed to induce complete skin differentiation due in part to necrosis.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.

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