Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Optimized Gene Transduction in Human Lung Organoids: A High-Efficiency Method for Advanced Research Applications
[Communications Biology] The authors optimized a method to enhance lentiviral vector transduction efficiency by physically disrupting the organoids to increase surface area, followed by spinoculation to apply shear force during cell dissociation.
Poly(2-alkyl-2-oxazoline) Hydrogels as Synthetic Matrices for Multicellular Spheroid and Intestinal Organoid Cultures
[Biomacromolecules] Researchers studied poly(2-alkyl-2-oxazoline) hydrogels with differing compressive moduli for their potential to support 3D cell growth.
Integrative Analysis of Patient-Derived Tumoroids and Ex Vivo Organoid Modeling of ARID1A Loss in Bladder Cancer Reveals Therapeutic Molecular Targets
[Cancer Letters] With a view to discover effective treatment options for AT-rich interactive domain-containing protein 1A (ARID1A)-deficient bladder cancer patients, scientists set out to identify targetable effectors dysregulated consequent to ARID1A deficiency.
Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition
[Cancer Research] Scientists developed a CRISPR screening pipeline in three-dimensionally grown patient-derived tumor organoid models.
Establishment of a Bat Lung Organoid Culture Model for Studying Bat-Derived Infectious Diseases
[Scientific Reports] Scientists established a culture method of bat lung organoid (BLO) from Rousettus leschenaultia that died of natural causes. The generated BLO successfully recapitulated the characteristics of pulmonary epithelial structure and morphology.
Clinical Applications of Human Organoids
[Nature Medicine] The authors showcase pivotal achievements in epithelial organoid research and technologies and provide an outlook for the future of organoids in advancing human health and medicine.
Uterine Organoids Reveal Insights into Epithelial Specification and Plasticity in Development and Disease
[Proceedings of The National Academy of Sciences of The United States of America] Using mouse genetic models, neonatal endometrial organoids, and assembloids, researchers uncovered parallels between normal epithelial differentiation and pathological states, highlighting conserved pathways that governed uterine epithelial fate decisions.
Tofacitinib and Budesonide Treatment Affect Stemness and Chemokine Release in IBD Patient-Derived Colonoids
[Scientific Reports] Researchers investigated cellular effects of pan-Janus Kinase inhibitor tofacitinib and the corticosteroid budesonide on uninflamed and TNF + Poly(I:C) stimulated human colon organoids from healthy donors and inflammatory bowel disease-patients.
UAEU Inaugurates Stem Cells Research Centre to Advance Regenerative Medicine
[Kazinform International News Agency] Under the patronage and in the presence Zaki Nusseibeh, Cultural Adviser to the UAE President and Chancellor of the United Arab Emirates University (UAEU), UAEU inaugurated the Stem Cells Research Centre, the first of its kind in the academic world in the UAE.
Synergistic Combination of Orally Available Safe-in-Man Pleconaril, AG7404, and Mindeudesivir Inhibits Enterovirus Infections in Human Cell and Organoid Cultures
[Cellular and Molecular Life Sciences] Researchers identified a synergistic combination of orally available, safe-in-man pleconaril, AG7404, and mindeudesivir, that at non-toxic concentrations effectively inhibited enterovirus replication in human cell and organoid cultures.
Patient-Derived Organoids and Xenografts Uncover Therapeutic Vulnerabilities in Colorectal Signet Ring Cell Carcinomas
[Clinical Cancer Research] Scientists derived nine patient-derived organoid and patient-derived xenograft models from colorectal signet ring cell carcinoma patients. Detailed histopathological characterization confirmed the fidelity of these models to the original tumors.
Modeling Sporadic Progressive Supranuclear Palsy in 3D Midbrain Organoids: Recapitulating Disease Features for In Vitro Diagnosis and Drug Discovery
[Annals of Neurology] The midbrain organoids (MOs) were generated by pooling iPSCs from four patients with sporadic probable progressive supranuclear palsy-Richardson's syndrome and compared them with MOs from three healthy control subjects.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.