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Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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iXCells Biotechnologies Joins International Collaboration to Evaluate Chemotherapeutic Toxicity in Human Organoids
[iXCells Biotechnologies] iXCells Biotechnologies announced it has entered an international collaboration with Rosebud Biosciences, Kantify, and Incite to evaluate off-target chemotherapeutic toxicities in patient-specific organoids
Modeling Pediatric Low-Grade Glioma Heterogeneity Using Human Forebrain Organoids
[Molecular Cancer] Investigators developed two organoid models for pediatric low-grade gliomas, which, after engraftment into mice, exhibited low-grade features.
Patient-Derived Ependymoma and Medulloblastoma Tumoroids: Generation, Biobanking, and Drug Screening
[Nature Protocols] Scientists presented a detailed protocol for the generation and maintenance of pediatric patient-derived tumoroids and pediatric patient-derived xenograft tumoroids directly from primary ependymoma and medulloblastoma tumor specimens,
Primary Human Intestinal Organoids Model Enteric Infection of Monkeypox Virus and Enable Scalable Drug Discovery
[Science Advances] Researchers demonstrated that primary organoids derived from human small intestine and rectal tissues support productive infection by both clade I and II monkeypox virus isolates.
UPR/ATF4/Noxa Pathway Overactivation through SERCA2 Inhibition or ONC201 Treatment Combined with ABT-737 Triggers Apoptosis in Chemoresistant Ovarian Cancer Cells and Patient-Derived Tumor Organoids
[Cell Death & Disease] The authors highlighted that ABT-737, through BCL-xL inhibition and synergy with ER stress inducers, triggers ovarian cancer death, offering promising strategies for overcoming chemoresistance in relapsed ovarian cancer.
Modeling of the Hepatitis B Virus Life Cycle and the Efficacy of Antivirals in Human iPSC-Derived Hepatic Organoids
[Bioscience Trends] Scientists established a hiPSC-derived multilineage hepatic organoid system that robustly supports the complete hepatitis B virus life cycle, including viral entry, replication, covalently closed circular DNA formation, antigen secretion, and production of infectious progeny virus.
Human Airway Organoids As a Versatile Model to Study BSL-4 Virus Replication and Pathogenesis
[Scientific Reports] Researchers generated airway organoids from both clinical donor tissues and commercially available nasal epithelial cells and showed in comparative analyses with whole lung tissue that these organoids are comparable in terms of cell composition.
Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes
[Advanced Science] Investigators examine progress toward bone organoid development within the broader landscape of soft-tissue organoid innovation and then use diabetes-associated skeletal disorders as a representative case study.
Piezoelectric Materials in Bone Organoids
[Advanced Healthcare Materials] The authors advance the central argument that piezoelectric mechanosensing represents a missing but essential biophysical axis in bone organoid development.
Oropouche Virus Infects Human Neural Progenitor Cells and Alters the Growth of Brain Organoids
[Iscience] Investigators presented a self-organized human iPSC-derived epicardium-myocardium organoid that mimics heart vascular plexus development and integration with myocardium sympathetic innervation.
Modeling Embryonic Heart Vascular Plexus Development and Sympathetic Innervation on a Human Heart Organoid
[Iscience] Scientists showed that a strain of Oropouche virus, FG_2020, phylogenetically related to the epidemic strain, efficiently and productively infects human neural progenitor cells and iPSC-derived brain organoids.
Microglia Cause HIV-Induced Transcriptional and Metabolic Changes in Human Neural Organoids
[Communications Biology] Researchers used a three-dimensional microglia-embedded human neural organoid model to investigate HIV-1–induced immunometabolic changes in the brain.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
