Organoid Modeling of Zika and Herpes Simplex Virus 1 Infections Reveals Virus-Specific Responses Leading to Microcephaly

Scientists used human brain organoids to study the mechanisms underlying microcephaly caused by Zika virus and herpes simplex virus.
[Cell Stem Cell]
Krenn, V., Bosone, C., Burkard, T. R., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Christoff, R. R., Garcez, P. P., Mirazimi, A., & Knoblich, J. A. (2021). Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.03.004 Cite
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Volastra Therapeutics Partners with Microsoft to Advance Metastatic Cancer Research

Volastra Therapeutics announced it will collaborate with Microsoft to develop tools that help detect drivers of cancer metastasis. The collaboration will develop automated machine learning tools capable of rapidly and accurately integrating insights across multiple datasets, including pathology slides and 3D tumor-derived organoids.
[Volastra Therapeutics (BusinessWire, Inc.)]
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Modeling Human Retinoblastoma Using Embryonic Stem Cell-Derived Retinal Organoids

The authors present a protocol to establish a novel human retinoblastoma organoid model derived from genetically engineered human embryonic stem cells.
[STAR Protocols]
Liu, H., Hua, Z.-Q., & Jin, Z.-B. (2021). Modeling human retinoblastoma using embryonic stem cell-derived retinal organoids. STAR Protocols, 2(2), 100444. https://doi.org/10.1016/j.xpro.2021.100444 Cite
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Symbiotic Polyamine Metabolism Regulates Epithelial Proliferation and Macrophage Differentiation in the Colon

Scientists showed that microbial polyamines reinforce colonic epithelial proliferation and regulate macrophage differentiation.
[Nature Communications]
Nakamura, A., Kurihara, S., Takahashi, D., Ohashi, W., Nakamura, Y., Kimura, S., Onuki, M., Kume, A., Sasazawa, Y., Furusawa, Y., Obata, Y., Fukuda, S., Saiki, S., Matsumoto, M., & Hase, K. (2021). Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon. Nature Communications, 12(1), 2105. https://doi.org/10.1038/s41467-021-22212-1 Cite
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Increased p53 Signaling Impairs Neural Differentiation in HUWE1-Promoted Intellectual Disabilities

Investigators identified p53 signaling as the central process altered in HUWE1-promoted X-linked intellectual disability syndromes.
[Cell Reports Medicine]
Aprigliano, R., Aksu, M. E., Bradamante, S., Mihaljevic, B., Wang, W., Rian, K., Montaldo, N. P., Grooms, K. M., Fordyce Martin, S. L., Bordin, D. L., Bosshard, M., Peng, Y., Alexov, E., Skinner, C., Liabakk, N.-B., Sullivan, G. J., Bjørås, M., Schwartz, C. E., & van Loon, B. (2021). Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities. Cell Reports Medicine, 100240. https://doi.org/10.1016/j.xcrm.2021.100240 Cite
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Bioengineering of the Digestive Tract: Approaching the Clinic

Scientists succinctly illustrate the three technologies that are closer to clinical translation—namely, human intestinal organoids, sphincter bioengineering and decellularization
[Cytotherapy]
Speer, A. L., Ren, X., McNeill, E. P., Aziz, J. M., Muir, S. M., Marino, D. I., Dadhich, P., Sawant, K., Ciccocioppo, R., Asthana, A., Bitar, K. N., & Orlando, G. (2021). Bioengineering of the digestive tract: approaching the clinic. Cytotherapy. https://doi.org/10.1016/j.jcyt.2021.02.006 Cite
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Generation of Human Pluripotent Stem Cell-Derived Fused Organoids with Oligodendroglia and Myelin

Scientists provide a step-by-step protocol for generating fused forebrain organoids derived from human pluripotent stem cells.
[STAR Protocols]
Kim, H., & Jiang, P. (2021). Generation of human pluripotent stem cell-derived fused organoids with oligodendroglia and myelin. STAR Protocols, 2(2), 100443. https://doi.org/10.1016/j.xpro.2021.100443 Cite
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Understanding the Cellular Origin and Progression of Esophageal Cancer Using Esophageal Organoids

Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches
[Cancer Letters]
Sachdeva, U. M., Shimonosono, M., Flashner, S., Cruz-Acuña, R., Gabre, J. T., & Nakagawa, H. (2021). Understanding the cellular origin and progression of esophageal cancer using esophageal organoids. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.03.031 Cite
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Modelling Hereditary Diffuse Gastric Cancer Initiation Using Transgenic Mouse-Derived Gastric Organoids and Single-Cell Sequencing

Using single‐cell RNA sequencing, researchers explored the transcriptional landscape of a murine organoid model of hereditary diffuse gastric cancer to characterize the impact of CDH1 loss in early tumorigenesis.
[Journal of Pathology]
Dixon, K., Brew, T., Farnell, D., Godwin, T. D., Cheung, S., Chow, C., Ta, M., Ho, G., Bui, M., Douglas, J. M., Campbell, K. R., El‐Naggar, A., Kaurah, P., Kalloger, S. E., Lim, H. J., Schaeffer, D. F., Cochrane, D., Guilford, P., & Huntsman, D. G. (n.d.). Modelling hereditary diffuse gastric cancer initiation using transgenic mouse-derived gastric organoids and single-cell sequencing. The Journal of Pathology, n/a(n/a). https://doi.org/https://doi.org/10.1002/path.5675 Cite
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Cannibalized Erythroblasts Accelerate Developmental Neurogenesis by Regulating Mitochondrial Dynamics

To investigate the role of junctional β-catenin in heme signaling, researchers employed neural organoids with stabilized intercellular junctions and an enhanced capacity for the recruitment of free cytoplasmic β-catenin.
[Cell Reports]
Özsoy, Ş., Vujovic, F., Simonian, M., Valova, V., Hunter, N., & Farahani, R. M. (2021). Cannibalized erythroblasts accelerate developmental neurogenesis by regulating mitochondrial dynamics. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108942 Cite
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Enhanced Anti-Cancer Activity of Andrographis with Oligomeric Proanthocyanidins through Activation of Metabolic and Ferroptosis Pathways in Colorectal Cancer

Scientists demonstrated the enhanced anti-cancer activity between two botanical extracts in terms of their ability to inhibit cancer cell growth, suppress colony formation and induce apoptosis. They validated these findings in subcutaneous xenograft models and in patient derived primary epithelial 3D organoids.
[Scientific Reports]
Shimura, T., Sharma, P., Sharma, G. G., Banwait, J. K., & Goel, A. (2021). Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer. Scientific Reports, 11(1), 7548. https://doi.org/10.1038/s41598-021-87283-y Cite
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