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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Multi-Zonal Liver Organoids from Human Pluripotent Stem Cells
[Nature] To evaluate hepatic zonal polarity, investigators developed a self-assembling zone-specific liver organoid by co-culturing ascorbate- and bilirubin-enriched hepatic progenitors derived from hiPSCs.
Generation of Human Adult Hepatocyte Organoids with Metabolic Functions
[Nature] Investigators demonstrated that the combined activation of Wnt and STAT3 signalling enabled long-term self-renewal of human adult hepatocyte organoids.
Fate and State Transitions during Human Blood Vessel Organoid Development
[Cell] Scientists inferred a gene regulatory network and use single-cell genetic perturbations to identify transcription factors and receptors involved in cell fate specification, including a role for MECOM in endothelial and mural specification.
Differences in chemotherapeutic drug sensitivity before and after patient-derived tumor organoid construction
[Toxicology and Applied Pharmacology] Tumor tissues were divided into two parts: one part was dissociated into a single-cell suspension, and the other part was used to culture tumor organoids.
Human Assembloid Model of the Ascending Neural Sensory Pathway
[Nature] Scientists established a human ascending somatosensory assembloid, a four-part assembloid generated from hPSCs that integrated somatosensory, spinal, thalamic, and cortical organoids to model the spinothalamic pathway.
Cartilage Repair: Unleashing PRP’s Potential in Organoid Models
[Cytotechnology] Investigators explore the synergistic interaction between platelet-rich plasma and cartilage organoids, a novel three-dimensional in vitro culture system that closely mimic the structural and functional properties of native cartilage.
I Peace Launches Personalized iPS Cell Services and Longevity Treatment in the US
[I Peace, Inc. (Businesswire)] I Peace, Inc. announced the launch of its personalized iPS cell production and longevity-focused rejuvenation therapies in the United States.
Microglia Determine an Immune-Challenged Environment and Facilitate Ibuprofen Action in Human Retinal Organoids
[Journal of Neuroinflammation] The authors generated hiPSC-derived microglia precursor cells and assembled them into retinal organoids.
Robust and Reproducible Human Intestinal Organoid-Derived Monolayer Model for Analyzing Drug Absorption
[Scientific Reports] Researchers developed a reproducible and robust culture method to generate a human intestinal organoid-derived monolayer model that could be applied to study drug absorption through a step-by-step approach.
Subclonal Response Heterogeneity to Define Cancer Organoid Therapeutic Sensitivity
[Scientific Reports] Investigators demonstrated the advantage of evaluating individual patient-derived cancer organoid heterogeneity to enhance the sensitivity of these assays for predicting clinical response.
Loss of Ubiquitin-Specific Protease 11 Mitigates Pulmonary Fibrosis in Human Pluripotent Stem Cell-Derived Alveolar Organoids
[International Journal of Stem Cells] Researchers examined the effects of loss of function of USP11 gene on the progression of pulmonary fibrosis by utilizing 3D cell culture alveolar organoids that replicated the structure and functions of the proximal and distal airways and alveoli.
Generation of Kidney Organoids Derived from Human Expanded Potential Stem Cells
[Cells & Development] A comparative analysis revealed that inhibiting the Hippo-YAP signaling pathway before nephron progenitor cell (NPC) generation effectively increased the number of NPCs, resulting in a more nephron-like structure.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
