Category Archives: Organoid

Organoid News is an online publication and email newsletter dedicated to the latest research about and featuring organoids.
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Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.

Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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Anti-Abortion Ethicists and Scientists Dominate Trump’s Fetal Tissue Review Board

Research advocates were eager to learn who Health and Human Services Secretary Alex Azar would appoint to the board and to see its ideological makeup. On July 31st they got their first look as it gathered online for a one-time meeting run by the National Institutes of Health.
[ScienceInsider]
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Collective Cell Mechanics of Epithelial Shells with Organoid-Like Morphologies

Scientists propose a mechanistic theory of epithelial shells which resemble small-organoid morphologies. Using a 3D surface tension-based vertex model, they reproduced the characteristic shapes from branched and budded to invaginated structures.
[Nature Communications]
Rozman, J., Krajnc, M., & Ziherl, P. (2020). Collective cell mechanics of epithelial shells with organoid-like morphologies. Nature Communications, 11(1), 3805. https://doi.org/10.1038/s41467-020-17535-4 Cite
Abstract

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Microbiota-Derived Metabolite Promotes HDAC3 Activity in the Gut

Intestinal exposure to inositol trisphosphate and phytate ingestion both promoted recovery following intestinal damage. Remarkably, inositol trisphosphate also induced growth of patient-derived intestinal organoids, stimulated HDAC3-dependent proliferation, and countered butyrate inhibition of colonic growth.
[Nature]
Wu, S., Hashimoto-Hill, S., Woo, V., Eshleman, E. M., Whitt, J., Engleman, L., Karns, R., Denson, L. A., Haslam, D. B., & Alenghat, T. (2020). Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature, 1–8. https://doi.org/10.1038/s41586-020-2604-2 Cite
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Taming Human Brain Organoids One Cell at a Time

The authors summarize recent approaches, progresses and challenges in resolving brain organoid’s complexity through single-cell transcriptomics.
[Seminars in Cell & Developmental Biology]
Atamian, A., Cordón-Barris, L., & Quadrato, G. (2020). Taming human brain organoids one cell at a time. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2020.05.022 Cite
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Developmental GABA Polarity Switch and Neuronal Plasticity in Bioengineered Neuronal Organoids

The authors report the directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
[Nature Communications]
Zafeiriou, M.-P., Bao, G., Hudson, J., Halder, R., Blenkle, A., Schreiber, M.-K., Fischer, A., Schild, D., & Zimmermann, W.-H. (2020). Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nature Communications, 11(1), 3791. https://doi.org/10.1038/s41467-020-17521-w Cite
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Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids

Researchers presented a simple and minimally invasive fine-needle aspiration-based organoid culture technique using a variety of tumor types including gastrointestinal, thyroid, melanoma, and kidney.
[iScience]
Vilgelm, A., Bergdorf, K., Wolf, M., Bharti, V., Shattuck-Brandt, R., Blevins, A., Jones, C., Phifer, C., Lee, M., Lowe, C., Hongo, R., Boyd, K., Netterville, J., Rohde, S., Idrees, K., Bauer, J. A., Westover, D., Reinfeld, B., Baregamian, N., … Weiss, V. L. (2020). Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101408 Cite
AbstractGraphical Abstract

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Patient-Derived Ovarian Cancer Organoids Capture the Genomic Profiles of Primary Tumors Applicable for Drug Sensitivity and Resistance Testing

Scientists developed expandable ovarian cancer organoids in less than three weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumors.
[Scientific Reports]
Nanki, Y., Chiyoda, T., Hirasawa, A., Ookubo, A., Itoh, M., Ueno, M., Akahane, T., Kameyama, K., Yamagami, W., Kataoka, F., & Aoki, D. (2020). Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing. Scientific Reports, 10(1), 12581. https://doi.org/10.1038/s41598-020-69488-9 Cite
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Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential

The authors report a method to generate ureteric bud organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis.
[Cell Reports]
Mae, S.-I., Ryosaka, M., Sakamoto, S., Matsuse, K., Nozaki, A., Igami, M., Kabai, R., Watanabe, A., & Osafune, K. (2020). Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential. Cell Reports, 32(4). https://doi.org/10.1016/j.celrep.2020.107963 Cite
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miR-3622a-3p Acts as a Tumor Suppressor in Colorectal Cancer by Reducing Stemness Features and EMT through Targeting Spalt-Like Transcription Factor 4

The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
[Cell Death & Disease]
Chang, S., Sun, G., Zhang, D., Li, Q., & Qian, H. (2020). MiR-3622a-3p acts as a tumor suppressor in colorectal cancer by reducing stemness features and EMT through targeting spalt-like transcription factor 4. Cell Death & Disease, 11(7), 1–19. https://doi.org/10.1038/s41419-020-02789-z Cite
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Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening

Scientists established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma (LADC). Extensive gene and histopathology profiling show that the tumor organoids retain the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
[iScience]
Li, Z., Qian, Y., Li, W., Liu, L., Yu, L., Liu, X., Wu, G., Wang, Y., Luo, W., Fang, F., Liu, Y., Song, F., Cai, Z., Chen, W., & Huang, W. (2020). Human lung adenocarcinoma-derived organoid models for drug screening. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101411 Cite
AbstractGraphical Abstract

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Pharmacogenomics of Aromatase Inhibitors in Postmenopausal Breast Cancer and Additional Mechanisms of Anastrozole Action

Estrogen receptor positive breast cancer organoids and aromatase inhibitor (AI)- or fulvestrant-resistant breast cancer cells were more sensitive to anastrozole plus estradiol than to AI alone.
[JCI Insight]
Cairns, J., Ingle, J. N., Dudenkov, T. T. M., Kalari, K. R., Carlson, E. E., Na, J., Buzdar, A. U., Robson, M. E., Ellis, M. J., Goss, P. E., Shepherd, L. E., Goodnature, B., Goetz, M. P., Weinshilboum, R. M., Li, H., Bari, M. G., & Wang, L. (2020). Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action. JCI Insight. https://doi.org/10.1172/jci.insight.137571 Cite
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