Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Organoid Modeling of Human Fetal Lung Alveolar Development Reveals Mechanisms of Cell Fate Patterning and Neonatal Respiratory Disease

[Cell Stem Cell] Researchers identified an alveolar-fated epithelial progenitor in human fetal lungs, which they grew as self-organizing organoids that modeled key aspects of cell lineage commitment.

LY6D Marks Pre-Existing Resistant Basosquamous Tumor Subpopulations

[Nature Communications] Using computational tools, organoids, and spatial tools, the authors showed that LY6D+ basosquamous cells represented a persister population lying on a central node along the skin lineage-associated spectrum of epithelial states.

Epithelial TGFβ Engages Growth-Factor Signaling to Circumvent Apoptosis and Drive Intestinal Tumorigenesis with Aggressive Features

[Nature Communications] Scientists identified a cohort of early-stage colorectal tumors, with aggressive features and a propensity to disseminate early, that were characterized by high epithelial cell-intrinsic TGFβ signaling.

The Chromatin Remodeler CHD6 Promotes Colorectal Cancer Development by Regulating TMEM65-Mediated Mitochondrial Dynamics via EGF and Wnt Signaling

[Cell Discovery] The authors reported that CHD6 was highly expressed in colorectal cancer, and that CHD6 knockdown inhibited cancer cell proliferation, migration, invasion, and tumorigenesis.

Ex Vivo Chemosensitivity Assay Using Primary Ovarian Cancer Organoids for Predicting Clinical Response and Screening Effective Drugs

[Human Cell] We prepared organoids using the cancer tissue-originated spheroid method from 61 patients with ovarian cancer. Chemosensitivity assays for paclitaxel and carboplatin were performed using the primary organoids from 50 patients who received the chemotherapy.

Engineered Organoids in Oral and Maxillofacial Regeneration

[iScience] The authors summarize the recent progress of novel approaches to engineering oral and maxillofacial organoids. They introduce the necessary components and their roles in forming oral and maxillofacial organoids.

Microglia-Containing Human Brain Organoids for the Study of Brain Development and Pathology

[Molecular Psychiatry] Scientists review the current methods used to generate microglia-containing human brain organoids (MC-HBOs) and provide opinions on the use of MC-HBOs for disease modeling and functional studies.

Crown Bioscience and ERS Genomics Announce Global CRISPR/Cas9 Licensing Agreement for Genome Editing Patents

[ERS Genomics Limited] Crown Bioscience, Inc. and ERS Genomics Ltd. have signed a global license agreement for access to the foundational CRISPR/Cas9 patent portfolio held by ERS, which provides the company full license to operate globally using CRISPR/Cas9 for gene editing.

SARS-CoV-2 Replication in Airway Epithelia Requires Motile Cilia and Microvillar Reprogramming

[Cell] Using primary nasal epithelial organoid cultures, researchers found the SARS-CoV-2 attached to motile cilia via the ACE2 receptor, then traversed the mucus layer, using motile cilia as tracks to access the cell body.

Postdoc Union Reaches Tentative Agreement with University of California

[Science Careers] After weeks of strikes and negotiating involving thousands of early-career researchers across the University of California (UC) system, the union representing UC postdocs and academic researchers announced it has reached a tentative agreement with administrators.

Performance Assessment and Economic Analysis of a Human Liver-Chip for Predictive Toxicology

[Communications Medicine] 870 Liver-Chips were analyzed to determine their ability to predict drug-induced liver injury caused by small molecules identified as benchmarks by the Innovation and Quality consortium, who has published guidelines defining criteria for qualifying preclinical models.

Dialysis Based-Culture Medium Conditioning Improved the Generation of Human Induced Pluripotent Stem Cell Derived-Liver Organoid in a High Cell Density

[Scientific Reports] Investigators developed a simple dialysis-based medium conditioning that fully utilized growth factors accumulation to improve hepatic differentiation of human iPSCs at a high cell density.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.

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