Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Intracellular Domain of Epithelial Cell Adhesion Molecule Induces Wnt Receptor Transcription to Promote Colorectal Cancer Progression

[Journal of Biomedical Science] Scientists used patient-derived organoids and xenografts, and various colorectal cancer cell lines were used to study the roles of epithelial cell adhesion molecule and its intracellular domains in Wnt receptor expression.

Biofabrication Strategies for Cardiac Tissue Engineering

[Current Opinion In Biotechnology] Investigators review recent cardiac engineering technologies ranging from microscaled organoids, millimeter-scaled heart-on-a-chip platforms, in vitro ventricle models sized to the fetal heart, larger cardiac patches seeded with billions of cells, and associated biofabrication technologies used to produce these models.

3D Embedded Bioprinting of Large-Scale Intestine with Complex Structural Organization and Blood Capillaries

[Biofabrication] A centimeter-scale intestine tissue that contains intestinal features, such as hollow tubular structure, capillaries and tightly connected epithelium with in vivo-like ring folds, crypt-villi, and microvilli is constructed by 3D embedding bioprinting.

A Positive Feedback Loop Between PFKP and C-Myc Drives Head and Neck Squamous Cell Carcinoma Progression

[Molecular Cancer] Investigators assessed the expression levels of PFKP and c-Myc in tumor and adjacent normal tissues from 120 HNSCC patients. A series of in vitro and in vivo experiments were performed to explore the impact of the feedback loop between PFKP and c-Myc on HNSCC progression.

Identification and Validation of Tumor-Specific T Cell Receptors From Tumor Infiltrating Lymphocytes Using Tumor Organoid Co-Cultures

[Cancer Immunology Immunotherapy] Tumor organoids-enriched tumor infiltrating lymphocytes (oeT) were obtained by repeatedly stimulation of autologous patient-derived organoids in vitro.

Characterization, In Vitro Elderly Digestion, and Organoids Cell Uptake of Curcumin-Loaded Nanoparticles

[Food Chemistry] Curcumin-loaded nanoparticles based on octyl succinate hydrate starch and sodium caseinate were prepared and the in vitro elderly digestion and absorption fate was investigated.

Galway Researcher Elected to Prestigious Scientific Body

[Silicon Republic] University of Galway researcher Prof Uri Frank has been elected a member of the European Molecular Biology Organization in recognition of his life sciences research over the past two decades.

CL429 Enhances the Renewal of Intestinal Stem Cells by Upregulating TLR2-YAP1

[International Immunopharmacology] Knockdown of YAP1 significantly attenuated the radioprotective effect of CL429 on intestinal organoids, indicating that CL429-mediated intestinal radioprotection is dependent on YAP1.

NF-κB Inhibitor Alpha Controls SARS-CoV-2 Infection in ACE2-Overexpressing Human Airway Organoids

[Scientific Reports] Researchers described an adult stem cell-derived human airway organoid model overexpressing the ACE2 receptor that supported robust viral replication while maintaining 3D architecture and cellular diversity of the airway epithelium.

Cancer Organoids 2.0: Modelling the Complexity of the Tumour Immune Microenvironment

[Nature Reviews Cancer] The authors discuss currently available and rapidly evolving 3D tumour organoid models that capture important immune features of the TME. They highlight diverse opportunities for organoid-based investigations of tumour immunity, drug development and precision medicine.

Engineered Matrices Reveal Stiffness-Mediated Chemoresistance in Patient-Derived Pancreatic Cancer Organoids

[Nature Materials] Researchers designed and engineered matrices that recapitulated the key hallmarks of the PDAC tumour extracellular matrix. They showed that patient-derived PDAC organoids developed resistance to several clinically relevant chemotherapies when cultured within high-stiffness matrices mechanically matched to in vivo tumors.

Intestinal Organoids to Model Salmonella Infection and Its Impact on Progenitors

[Scientific Reports] Given that intestinal organoids growth was sustained by stem cells and progenitors activity, scientists used this model to document the effects of Salmonella Typhimurium infection on epithelial proliferation and differentiation and compared it to an in vivo model of Salmonella infection in mice.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.