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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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USC Researchers Launch Study of the Most Complex Lab-Grown Kidney Structures
[Keck School of Medicine of USC] A $2.1 million grant from CIRM supports the new project designed to understand how mature lab-grown kidney structures, which combine the kidney’s filtering and urine-collecting components, can improve the study of disease and development of therapies.
An In Vitro Menstrual Cycle Using Organoids Captures Epithelial Cell Transitions during Menstruation and Regeneration of the Human Endometrium
[Cell Stem Cell] Investigators used human endometrial organoids to establish an in vitro menstrual cycle protocol that recapitulates cyclical epithelial dynamics.
Electrodeposition-Optimized PEDOT Interfaces on Printed Circuit Boards for Stable, Low-Impedance Organoid Electrophysiology
[ACS Applied Materials & Interfaces] Researchers introduced PEDOT-coated printed circuit board electrodes as a biosensing platform for low-noise recording of organoid electrical activity.
Robust Generation of Distal Respiratory Airway Organoids by an Engineered Cuboid Chip
[Journal of Nanobiotechnology] Scientists developed a robust differentiation protocol to derive distal respiratory airway organoids from hPSCs and investigated their role in the treatment of chronic obstructive pulmonary disease.
Accessory Inner Segment-Like Structures Develop in Human Retinal Organoids
[Stem Cell Reviews and Reports] Investigators determined whether retinal organoids exhibit an accessory inner segment-like structure, to support future in vitro studies of its role in photoreceptor structure and disease.
Organoids in Cancer Therapy: Translational Applications and Clinical Promise
[Molecular Cancer] The authors summarize the multidimensional applications of organoids in translational cancer therapy, critically discuss their advantages and current limitations, and outline key directions for future development.
Organoids As Platforms for Infectious Disease Research
[Nature Reviews Bioengineering] Scientists explore the diverse applications of human organoids in investigating organ-specific infections and disease manifestations across major physiological systems with a primary emphasis on viral pathogens.
Advanced In Vitro Cardiac Models for Drug Evaluation: Integration of Organoids, Engineered Tissues, and Microphysiological Systems
[Microsystems & Nanoengineering] The authors review highlights recent progress in biomimetic platforms that more faithfully recapitulate the structure and function of the human myocardium, including engineered three-dimensional tissues, chambered ventricular constructs, self-organizing cardiac organoids, and microphysiological systems.
Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma-Brain Organoid Interfaces
[Advanced Healthcare Materials] Scientists presented a bioengineered assembloid system that integrates glioblastoma cells encapsulated in self-degradable 5% oxidized alginate microgel with dorsal forebrain organoids to recapitulate early tumor-host interactions during glioblastoma invasion toward the brain.
Accelerating Leigh Syndrome Drug Discovery through Deep Learning Screening in Brain Organoids
[Nature Communications] Researchers highlighted azoles as promising candidates for Leigh and demonstrate the potential of combining in silico screens with human brain organoids as new approach methodologies
Retinoic Acid Drives Cell Fate Specification, Maturation, and Retinal Regionality in Human Retinal Organoids
[Nature Communications] Scientists showed that temporal and dosage-dependant modulation of retinoic acid during human retinal organoid differentiation induces distinct changes in retinal cell abundance, maturation, and organisation.
Patient-Derived Pediatric Brain Tumor Orthotopic Xenografts and Tumor Organoids Faithfully Recapitulate Primary Tumors
[Science Advances] Investigators described the establishment of tumor organoid (TO) and TO xenografts from patient-derived orthotopic xenografts of medulloblastoma, embryonal tumor with multilayer rosettes, and atypical teratoid rhabdoid tumors.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
