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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Co-Culture of Human AT2 Cells with Fibroblasts Reveals a MUC5B Phenotype: Insights from an Organoid Model
[Molecular Medicine] Researcher analyzed the interaction of primary fibroblasts and alveolar type 2 pneumocytes in the organoid model. Single-cell analysis, histology, and qRT-PCR revealed that fibroblasts expressing high levels of fibrosis markers regulated STAT3 signaling in AT2 cells, which is accompanied by cystic organoid growth and MUC5B expression.
Divergent WNT Signaling and Drug Sensitivity Profiles within Hepatoblastoma Tumors and Organoids
[Nature Communications] To characterize the heterogeneity in hepatoblastoma and identify novel targeted therapies, researchers performed comprehensive analysis of hepatoblastomas and tumor-derived organoids using single-cell RNA-seq/ATAC-seq, spatial transcriptomics, and high-throughput drug profiling.
An Integrated Transcriptomic Cell Atlas of Human Neural Organoids
[Nature] Investigators integrated 36 single-cell transcriptomic datasets spanning 26 protocols into one integrated human neural organoid cell atlas totalling more than 1.7 million cells.
Proximal Tubule Cell Maturation Rate and Function Are Controlled by PPARα Signaling in Kidney Organoids
[Communications Biology] Scientists performed time-course single-cell RNA sequencing of kidney organoids and revealed cell heterogeneity in the maturation rate of the proximal tubule.
Targeting the NOTCH2/ADAM10/TCF7L2 Axis-Mediated Transcriptional Regulation of Wnt Pathway Suppresses Tumor Growth and Enhances Chemosensitivity in Colorectal Cancer
[Advanced Science] Through high-throughput screening of 24 inhibitors on 12 colorectal cancer and three colorectal organoids in this organoid living biobank, adavivint was found to exhibit anti-tumor activity and low toxicity in colorectal organoids, independent of the canonical Wnt/β-catenin signaling.
IL-10RA Governor the Expression of IDO in the Instruction of Lymphocyte Immunity
[British Journal of Cancer] Human bone marrow mesenchymal stem cells with indoleamine 2,3-dioxygenase (IDO) or IL-10RA knockdown were co-cultured with healthy donor T cells to assess immunosuppression. Pancreatic ductal adenocarcinoma organoid anticancer activity was also tested in these co-cultures.
Identification of Nicotinic Acetylcholine Receptor for N-Acetylcysteine to Rescue Nicotine-induced Injury Using Beating Cilia in Primary Tissue Derived Airway Organoids
[Advanced Science] Patient tissue-derived airway organoids for modeling smoking-induced injury, therapeutic investigation, and mechanism studies were developed.
Generating Skin-Derived Precursor-Like Cells from Human-Induced Pluripotent Stem Cell-Derived Skin Organoids
[Experimental Dermatology] Investigators developed a protocol to isolate skin-derived precursor-like cells (SKP-like cells) from human skin organoids. SKP-like cells derived from SKOs exhibited characteristic spheroid morphology and were capable of self-renewal in defined SKP growth medium.
CRISPR-Based Genetic Screens in Human Pluripotent Stem Cells Derived Neurons and Brain Organoids
[Cell and Tissue Research] Investigators discuss current challenges and future directions for using CRISPR-based screens in furthering our understanding of neurological diseases and developing potential therapeutic strategies.
Global 3Rs Winners
[AAALAC International] Anja Hess, PhD student at The International Max Planck Research School for Biology And Computation, has been awarded AAALAC Global 3Rs Award for her work “Single-cell transcriptomics stratifies organoid models of metabolic dysfunction-associated steatotic liver disease".
CRIPTO’s Multifaceted Role in Driving Aggressive Prostate Cancer Unveiled by In Vivo, Organoid, and Patient Data
[Oncogene] Scientists demonstrated that suppressing Cripto in vivo significantly decreased invasive cell behavior in aggressive tumors, highlighting a critical oncogenic function of CRIPTO in advanced prostate cancer.
Organoid Models of Breast Cancer in Precision Medicine and Translational Research
[Molecular Biology Reports] Investigators evalurate a variety of breast cancer (BC) studies performed on organoid culture systems. Additionally, they report the potential of using organoid models in BC translational research, especially in immunotherapy, drug screening, and precision medicine.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
