Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Drug Screening at Single-Organoid Resolution via Bioprinting and Interferometry

[Nature Communications] Researchers presented a pipeline to generate bioprinted tumor organoids linked to label-free, time-resolved imaging via high-speed live cell interferometry and machine learning-based quantitation of individual organoids.

Nanoengineering of Gold Nanoribbon-Embedded Isogenic Stem Cell-Derived Cardiac Organoids

[Rsc Advances] Scientists presented a proof-of-concept study for the integration of biofunctionalized gold nanoribbons with hiPSC-derived isogenic cardiac organoids to enhance tissue function and maturation.

Effects of Acute Low-Moderate Dose Ionizing Radiation to Human Brain Organoids

[PLOS One] The authors generated brain/cerebral organoids from human iPSCs to study the radiosensitivity of human brain cells, including neurons, astrocytes, and oligodendrocytes.

Engineered Extracellular Matrices Facilitate Brain Organoids from Human Pluripotent Stem Cells

[Annals Of Clinical And Translational Neurology] Investigators generated brain organoids using engineered extracellular matrix comprised of human fibrillar fibronectin supported by a highly porous polymer scaffold.

A T Cell-Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy

[Advanced Science] To facilitate drug discovery combating immunosuppressive pancreatic ductal adenocarcinoma, a high-throughput drug screen platform was established with the newly developed T cell-incorporated pancreatic tumor organoid model.

Fabrication of Oxygen-Carrying Microparticles Functionalized with Liver ECM-Proteins to Improve Phenotypic Three-Dimensional In Vitro Liver Assembly, Function, and Responses

[Biotechnology And Bioengineering] Hepatocytes and hepatic stellate cells exhibited more pronounced phenotypic arrangements when cocultured with laminin-511 and 521 modified chitosan microparticles.

Portable and Integrated Microfluidic Flow Control System Using Off-the-Shelf Components Towards Organs-on-Chip Applications

[Biomedical Microdevices] 3D printing was used to fabricate a custom-designed platform box for mounting the chosen smallest footprint components. A demonstrator system was realized for lung-on-a-chip experiments.

Enhancement of CAR-T Cell Activity against Cholangiocarcinoma by Simultaneous Knockdown of Six Inhibitory Membrane Proteins

[Cancer Communications] Researchers knocked down immune checkpoints and immunosuppressive molecular receptors in CAR-T cells by constructing two clusters of small hairpin RNAs and evaluated the engineered CAR-T cells for antitumor activity both in vitro, using tumor cell lines and cholangiocarcinoma organoid models, and in vivo, using humanized mouse models.

Advances in Stem Cell and Other Therapies for Huntington’s Disease: An Update

[Brain Research Bulletin] The authors summarize the recent research in stem cells, genetic modifications, and organoids as a potential for treatment of Huntington’s disease.

Preclinical Models of Neuroendocrine Prostate Cancer

[Current Protocols] Scientists provide a comprehensive view of the available models for neuroendocrine prostate cancer (NEPC) detailing their strengths and limitations, and describe novel approaches to expand the repertoire of preclinical models to better study, prevent, or reverse NEPC.

Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development

[Stem Cell Reviews And Reports] The authors review the events of early retinal development both in animal embryos and human retinal organoids (hROs) studies, and summarize the application prospect, challenges and cutting-edge techniques of hROs for uncovering the principles and mechanisms of retinal development and related developmental disorder.

Enhancing the Neuroprotective Effect of Squid Outer Skin Astaxanthin Against Rotenone-Induced Neurotoxicity in In-Vitro Model for Parkinson’s Disease

[Food And Chemical Toxicology] Scientists evaluated the effect of astaxanthin in preventing rotenone-induced toxicity of SK-N-SH human neuroblastoma cells in an in vitro model of experimental Parkinsonism.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.