Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

WITec Announces Paper Award 2022 Winners

[Oxford Instruments] The WITec Paper Awards 2022 have been given to scientists from the US, Germany and China, recognizing their work in cement chemistry, pharmacy and methane hydrate chemistry.

Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging Variants

[mBio] Scientists reported an organoid culture system of the nasal epithelium. They derived nasal organoids from easily accessible nasal epithelial cells with a perfect establishment rate.

Hypoxia-Induced HMGB1 Promotes Glioma Stem Cells Self-Renewal and Tumorigenicity via RAGE

[iScience] Investigators reported that HMGB1 was overexpressed in human glioblastoma specimens. Hypoxia promoted the expression and secretion of HMGB1 in glioma stem cells

Direct Visualization of the Transition Status during Neural Differentiation by Dual-Fluorescent Reporter Human Pluripotent Stem Cells

[Stem Cell Reports] Investigators induced the differentiation of cortical neurons from dual-reporter human iPSCs, successfully visualizing cell-fate conversion in 2D culture and 3D organoids.

Intestinal Epithelial Responses to IL-17 in Adult Stem Cells-Derived Human Intestinal Organoids

[Journal of Crohn's and Colitis] Investigators found that organoid-forming efficiency, cell viability and proliferation of enteroids were decreased in proportion to interleukin-17A (IL-17) concentration.

Thymidine Kinase 1 Mediates the Synergistic Antitumor Activity of Ubenimex and Celecoxib via Regulation of Cell Cycle in Colorectal Cancer

[Journal of Pharmacology and Experimental Therapeutics] Scientists revealed that ubenimex and/or celecoxib exerted anti–colon cancer effects in vitro and in vivo, and the efficacy was significantly enhanced when the two drugs were combined.

Label-Free Three-Photon Imaging of Intact Human Cerebral Organoids for Tracking Early Events in Brain Development and Deficits in Rett Syndrome

[eLife] The authors demonstrated label-free three-photon imaging of whole, uncleared intact organoids to assess early events of early human brain development.

NeuroD Research Group Awarded the Sargenti Research Grant

[NeuroD Lab] Elena Daoutsali and Ronald Buijsen from the NeuroD research group were awarded the Sargenti Research Grant, organized by the Neuroscience Research Theme. The grant was for the field of neurodegenerative diseases and made possible through a donation from the legacy of mr. Sargenti to the Leiden University Fund.

Functional Neuronal Circuitry and Oscillatory Dynamics in Human Brain Organoids

[Scientific Reports] The authors extended gastruloid culture conditions to capture features of embryonic blood development through a combination of immunophenotyping, detailed transcriptomics analysis, and identification of blood stem/progenitor cell potency.

Understanding Immune-Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform

[Advanced Science] The authors reported the development of a human brain organoid microphysiological analysis platform to discover the dynamic process of immune-driven brain aging.

Gut Microbiota-Derived Metabolites Confer Protection against SARS-CoV-2 Infection

[Gut Microbes] Researchers defined multiple pathways by which the gut microbiome protects mammalian hosts from SARS-CoV-2 intranasal infection, both locally and systemically, via production of short-chain fatty acids.

Using 2D and 3D Pluripotent Stem Cell Models to Study Neurotropic Viruses

[Frontiers in Virology] The authors review the current state of technology in stem cell-based modeling of the central nervous system and how these models can be used to determine viral tropism and identify cellular phenotypes to investigate virus-host interactions and facilitate drug screening.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.

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