Cancer Stem Cell News
Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Subscribe|Follow Us On
Endodermal Organoids Along Two Axes: Single-Organ Fidelity, Inter-Organ Reconstruction, and the Unbuilt Gut-Lung Frontier
[Stem Cell Reviews and Reports] Scientists review the organoid work across the gut, liver, and lung and propose that the two orthogonal axes of advancement be analyzed separately.
Developmental Xenocortication Using Human-Derived Organoids in Mice
[Nature] The authors established a transplantation platform using a genetic strategy to effectively deplete glutamatergic neurons from mouse neocortex and hippocampus (apallial) and neonatally engraft the cortical cavity with human stem-cell-derived cortical organoids to generate xenocortical mice.
Quantitative Imaging of Dynamic Processes in Intestinal Organoids
[Nature Protocols] The authors present protocols for long-term imaging and quantitative analysis of intestinal organoids. They outline strategies for optimizing organoid health, imaging conditions, and experimental interventions to ensure efficient downstream analysis,
Three-Dimensional Tissue Models Replace Traditional Animal Frameworks in Medical Research
[AZO Life Sciences] With support from a $72,419 grant, University of Arkansas at Little Rock researcher Dr. Sujan Ghosh is developing a 3D tissue scaffold that more closely mimics the microscopic architecture of the human small intestine.
Aptar Pharma and Massachusetts General Hospital Collaborate on Platform to Establish Predictive, Data-Driven Model for Advancing Nose-to-Brain Drug Delivery
[AptarGroup, Inc.] AptarGroup, Inc. announced that it has signed an agreement for a research collaboration led by Dr. Alice Stanton from Massachusetts General Hospital to advance the science of nose-to-brain drug delivery.
hiPSC-Derived Organoids and Organ-on-Chip Systems: New Frontiers in Neural Tube Defect Research
[Stem Cell Reviews and Reports] Scientists synthesize evidence on the genetic, environmental, and morphogenetic mechanisms associated with neural tube defects and evaluate the applications and limitations of human organoid and organoid-on-chip models in this field.
H3K27M Drives OPC Stemness and Intrathecal Therapeutic Vulnerability in Brainstem Glioma Organoids
[Cell Stem Cell] Researchers established a patient-derived brainstem glioma organoid platform with high success. Multi-omics and functional assays revealed that diffuse midline gliomas maintain oligodendrocyte precursor cell (OPC) stemness by dysregulating ACTIVIN signaling.
Evaluation of Anti-Tumor Drugs by Simulating Physiological Absorption and Metabolism with a Multi-Organoid System
[Cell Systems] The authors established an intestine-liver-tumor multi-organoid system to simulate in vivo absorption and metabolism, which allows for more physiologically relevant evaluations of drug efficacy and toxicity.
Elongating Human Heart Organoids Recapitulate Early Cardiac Morphogenesis and Axial Organization
[Developmental Cell] Scientists generated elongating heart organoids from hiPSCs that undergo coordinated elongation and looping-like curvature, resembling early cardiac morphogenesis.
Elucidating the Role of DEAF1 in Neurodevelopment and Shared Molecular Pathways in High-Risk Autism Genes Using Cortical Organoids
[Science Advances] Investigators showed that a DEAF1 mutation in hESCs disrupts chromatin accessibility at neuronal gene loci, leading to significant transcriptional alterations.
Multicellular Rosette Formation Guides Epithelial Tissue Assembly in Pancreatic Ductal Adenocarcinoma Cell Organoids
[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that the transition from a disordered mesenchymal state to a columnar epithelial structure in branched pancreatic ductal adenocarcinoma organoids is associated with rosette formation.
Pathways of Epithelial Barrier Breakdown and Remodeling in Esophageal Organoids by Commonly Used Surfactants
[Allergy] The authors investigated the molecular and functional consequences of sodium dodecyl sulfate and cocamidopropyl betaine exposure in primary eosinophilic esophagitis-derived esophageal organoids and air-liquid interface cultures derived from biopsy tissue samples.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
