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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Thymic Epithelial Organoids Mediate T-Cell Development
[Development] Scientist identified conditions enabling mouse thymic epithelial progenitor cell proliferation and development into organoids with diverse cell populations and transcriptional profiles resembling in vivo thymic epithelial cells (TECs) more closely than traditional TEC cultures.
Characterizing the Effects of Triclosan and Triclocarban on the Intestinal Epithelial Homeostasis Using Small Intestinal Organoids
[Journal of Hazardous Materials] A novel 3D intestinal organoid model was utilized to investigate that exposure to TCS/TCC led to a compromised self-renewal and differentiation of intestinal stem cells.
Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β Cell Pyroptosis Upon Viral Infection
[Cell Stem Cell] Investigators utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples, revealing an accumulation of proinflammatory macrophages.
Inhibition of Sterol O-Acyltransferase 1 Blocks Zika Virus Infection in Cell Lines and Cerebral Organoids
[Communications Biology] Researchers systematically investigated the neutral lipid–synthesizing enzymes diacylglycerol O-acyltransferases and the sterol O-acyltransferase 1 in orthoflavivirus infection.
Resistance to SARS-CoV-2 Infection in Camelid Nasal Organoids Is Associated with Lack of ACE2 Expression
[NPJ Viruses] The authors investigated the susceptibility of camelids to SARS-CoV-2 using novel well-differentiated camelid nasal organoids. They showed that camelid nasal organoids are highly susceptible to Middle East respiratory syndrome coronavirus infection, but not to infection with different SARS-CoV-2 variants.
Thymic Epithelial Organoids Mediate T Cell Development
[Development] Researchers identified conditions enabling mouse thymic epithelial progenitor cell proliferation and development into organoids with diverse cell populations and transcriptional profiles resembling in vivo thymic epithelial cells (TECs) more closely than traditional TEC cultures.
Melatonin Mitigates Chemotherapy-Induced Small Intestinal Atrophy in Rats and Reduces Cytotoxicity in Murine Intestinal Organoids
[PLOS One] The authors elucidated the potential of melatonin and misoprostol to reduce 5-fluorouracil-induced small intestinal mucositis. Morphological and cellular changes in the jejunum, along with colonic faecal water content were quantified in rats as markers for chemotherapy-induced mucositis.
Hyperglycemic Environments Directly Compromise Intestinal Epithelial Barrier Function in an Organoid Model and Hyaluronan (∼35 kDa) Protects via a Layilin Dependent Mechanism
[Matrix Biology] Intestinal organoids derived from mouse colon were grown in normal glucose media (5 mM) or high glucose media (25 mM) to study the impact of hyperglycemic stress on the intestinal barrier.
Salivary Gland Organoid Transplantation as a Therapeutic Option for Radiation-Induced Xerostomia
[Current Stem Cell Research & Therapy] Human salivary gland stem cells were isolated from the salivary gland tissues and cultured in both Matrigel and collagen. Investigators compared the gene and protein expression patterns of salivary gland–specific markers and measured amylase activity in the two types of human salivary gland organoids.
NSF Invests $14M in Bioengineered Systems and Ethical Biocomputing Research
[National Science Foundation] The US National Science Foundation (NSF) has invested $14 million in seven interdisciplinary research projects through the Emerging Frontiers in Research and Innovation: Biocomputing through EnGINeering Organoid Intelligence program.
Life Sciences Facility Launched in Cardiff
[Scientist Live] Global life science and 3D biology pioneers Molecular Devices has launched a new life sciences facility in Cardiff, dedicated to research, development and industrial-scale manufacture of organoids.
Organoid as a Promising Tool for Primary Liver Cancer Research: A Comprehensive Review
[Cell & Bioscience] Investigators summarize the progress of research on liver cancer organoids and their potential application as disease models.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
