Genome Researchers Question Security Provisions in New US Senate Bill

Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science]
Editorial
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Menstrual Flow as a Non-Invasive Source of Endometrial Organoids

The authors presented an alternative technique based on deriving organoids from menstrual flow. They demonstrated that organoids could be derived from gland fragments recovered from menstrual flow.
[Communications Biology]
Cindrova-Davies, T., Zhao, X., Elder, K., Jones, C. J. P., Moffett, A., Burton, G. J., & Turco, M. Y. (2021). Menstrual flow as a non-invasive source of endometrial organoids. Communications Biology, 4(1), 1–8. https://doi.org/10.1038/s42003-021-02194-y Cite
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Modeling Pancreatic Pathophysiology Using Genome Editing of Adult Stem Cell-Derived and Induced Pluripotent Stem Cell (iPSC)-Derived Organoids

Scientists provide highlights on the development of organoid technology, and the use of this culture system to study the pathophysiology of specific mutations in the development of pancreatic and gastric cancer.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Sekine, K., Ogawa, S., Tsuzuki, S., Kobayashi, T., Ikeda, K., Nakanishi, N., Takeuchi, K., Kanai, E., Otake, Y., Okamoto, S., Kobayashi, T., Takebe, T., & Taniguchi, H. (2020). Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media. Scientific Reports, 10(1), 17937. https://doi.org/10.1038/s41598-020-73908-1 Cite
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Building a Stem Cell-Based Primate Uterus

Investigators discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organizing cultures, or by controlled assembly through microfluidic and print-based technologies.
[Communications Biology]
Bergmann, S., Schindler, M., Munger, C., Penfold, C. A., & Boroviak, T. E. (2021). Building a stem cell-based primate uterus. Communications Biology, 4(1), 1–12. https://doi.org/10.1038/s42003-021-02233-8 Cite
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Impedance Measurement System for Assessing the Barrier Integrity of Three-Dimensional Human Intestinal Organoids

Scientists developed an impedance system to measure the change in electrical resistance of 3D HIOs depending on the integrity of the intestinal epithelial cell membrane, which can reflect functionality and maturity.
[Analytical Chemistry]
Ahn, J., Jung, K. B., Kwon, O., Choi, M.-S., Ahn, J.-H., Han, H.-Y., Jung, C.-R., Yoon, S., Son, M.-Y., & Oh, J.-H. (2021). Impedance Measurement System for Assessing the Barrier Integrity of Three-Dimensional Human Intestinal Organoids. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.1c00655 Cite
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Two Vet Med Scholars Awarded Prestigious Canada Research Chairs

The Canadian federal government announced more than 150 new and renewed Canada Research Chairs (CRCs) at institutions across the country. Dr. Jack Chu’s successful CRC Tier II application focused on using stem cells to model human and animal developmental clocks and related disorders.
[University of Calgary]
Press Release
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Five VP&S Teams Awarded Vagelos Precision Medicine Grants

The annual Vagelos Precision Medicine Pilot Grants have been awarded to five teams of VP&S researchers conducting innovative basic science, translational, and clinical research across multiple diseases, from novel cancer therapeutics to health disparities research.
[Columbia University Irving Medical Center]
Press Release
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Generation of Patterned Kidney Organoids That Recapitulate the Adult Kidney Collecting Duct System from Expandable Ureteric Bud Progenitors

Researchers reported the generation of an expandable, 3D branching ureteric bud (UB) organoid culture model that could be derived from primary UB progenitors from mouse and human fetal kidneys, or generated de novo from human PSCs.
[Nature Communications]
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Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions

Using ex vivo cell models, investigators analyzed SARS-Cov2 interactions with kidney tubular cells and assessed direct tubular injury. These models comprised primary human kidney epithelial cells and more quiescent three-dimensional kidney spheroids.
[Clinical Journal of the American Society of Nephrology]
Omer, D., Pleniceanu, O., Gnatek, Y., Namestnikov, M., Cohen-Zontag, O., Goldberg, S., Friedman, Y. E., Friedman, N., Mandelboim, M., Vitner, E., Achdout, H., Avraham, R., Zahavy, E., Israely, T., Mayan, H., & Dekel, B. (2021). Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions. Journal of the American Society of Nephrology. https://doi.org/10.1681/ASN.2020111546 Cite
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Extension of Retinofugal Projections in an Assembled Model of Human Pluripotent Stem Cell-Derived Organoids

Retinal organoids were generated and organized into an in vitro assembloid model of the visual system with cortical and thalamic organoids.
[Stem Cell Reports]
Fligor, C. M., Lavekar, S. S., Harkin, J., Shields, P. K., VanderWall, K. B., Huang, K.-C., Gomes, C., & Meyer, J. S. (2021). Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.05.009 Cite
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Fungal Brain Infection Modeled in a Human-Neurovascular-Unit-on-a-Chip with a Functional Blood-Brain Barrier

Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.
[Nature Biomedical Engineering]
Kim, J., Lee, K.-T., Lee, J. S., Shin, J., Cui, B., Yang, K., Choi, Y. S., Choi, N., Lee, S. H., Lee, J.-H., Bahn, Y.-S., & Cho, S.-W. (2021). Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier. Nature Biomedical Engineering, 1–17. https://doi.org/10.1038/s41551-021-00743-8 Cite
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