Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Clonal Evolution of Long-Term Expanding Head and Neck Cancer Organoid: Impact on Treatment Response for Personalized Therapeutic Screening

[Oral Oncology] To investigate whether head and neck cancer organoids could maintain the genetic characteristics of their original tumors and elucidate the clonal evolution process during a long-term passage, researchers performed targeted sequencing, covering 377 cancer-related genes and adopted a sub-clonal fraction model.

Stem Cell-Derived Organoid Models for SARS-CoV-2 and Its Molecular Interaction with Host Cells

[Molecular Biology Reports] There is an urgent need for physiological models to study SARS-CoV-2 infection during the pandemic. Human stem cell-derived organoids can provide insight into understanding the SARS-CoV-2 cell entry molecular mechanism.

Spatiotemporal, Optogenetic Control of Gene Expression in Organoids

[Nature Methods] Scientists combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns.

Scalable Generation of Pre-Vascularized and Functional Human Beige Adipose Organoids

[Advanced Science] A scalable system was proposed to generate pre-vascularized and functional human beige adipose tissue organoids using the human stromal vascular fraction of white adipose tissue as a source of adipose and endothelial progenitors.

Human Organoids Are Superior to Cell Culture Models for Intestinal Barrier Research

[Frontiers in Cell and Developmental Biology] Investigators performed a detailed functional characterization of human intestinal organoid cultures under different conditions with the aim to suggest an optimized ex-vivo model to further analyze inflammation-induced intestinal epithelial barrier dysfunction.

Cigarette Smoke Restricts the Ability of Mesenchymal Cells to Support Lung Epithelial Organoid Formation

[Frontiers in Cell and Developmental Biology] The authors assessed the effect of cigarette smoke-exposure and the endoplasmic reticulum stress inducer Thapsigargin on Wnt/β-catenin signaling activation in MRC-5 fibroblasts, and on their ability to support lung epithelial organoid formation.

The TRIPLEX Study: Use of Patient-Derived Tumor Organoids as an Innovative Tool for Precision Medicine in Triple-Negative Breast Cancer

[BMC Cancer] The TRIPLEX study was a single-center observational study conducted to investigate the feasibility of generating patient-derived tumor organoids from triple negative breast cancer and to evaluate their ability to predict clinical response.

Vaginal Bacteria Elicit Acute Inflammatory Response in Fallopian Tube Organoids

[Reproductive Sciences] To facilitate in vitro mechanistic studies in pelvic inflammatory disease and subsequent tubal factor infertility, researchers established patient tissue derived fallopian tube organoids.

Application of Organoids in Regenerative Medicine

[Stem Cells] Scientists review the available applications of organoids in regenerative medicine and the current challenges concerning this field.

Self-Organizing Models of Human Trunk Organogenesis Recapitulate Spinal Cord and Spine Co-Morphogenesis

[Nature Biotechnology] Scientists reported the generation of human trunk-like structures that modeled the co-morphogenesis, patterning and differentiation of the human spine and spinal cord.

Cyclic Stretching Triggers Cell Orientation and Extracellular Matrix Remodeling in a Periodontal Ligament 3d in Vitro Model

[Advanced Healthcare Materials] Researchers developed a customized bioreactor that allowed dynamic loading of periodontal ligament-derived fibroblasts. A collagen-based hydrogel mixture was optimized to maintain structural integrity and constant cell growth during stretching.

A Microwell Platform for High-Throughput Longitudinal Phenotyping and Selective Retrieval of Organoids

[Cell Systems] Investigators developed a microwell-based method that enabled high-throughput quantification of image-based parameters for organoids grown from single cells, which could further be retrieved from their microwells for molecular profiling.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.