Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
Research advocates were eager to learn who Health and Human Services Secretary Alex Azar would appoint to the board and to see its ideological makeup. On July 31st they got their first look as it gathered online for a one-time meeting run by the National Institutes of Health.
Scientists propose a mechanistic theory of epithelial shells which resemble small-organoid morphologies. Using a 3D surface tension-based vertex model, they reproduced the characteristic shapes from branched and budded to invaginated structures.
Intestinal exposure to inositol trisphosphate and phytate ingestion both promoted recovery following intestinal damage. Remarkably, inositol trisphosphate also induced growth of patient-derived intestinal organoids, stimulated HDAC3-dependent proliferation, and countered butyrate inhibition of colonic growth.
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The authors summarize recent approaches, progresses and challenges in resolving brain organoid’s complexity through single-cell transcriptomics.
[Seminars in Cell & Developmental Biology]
The authors report the directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
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Zafeiriou, M.-P., Bao, G., Hudson, J., Halder, R., Blenkle, A., Schreiber, M.-K., Fischer, A., Schild, D., & Zimmermann, W.-H. (2020). Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nature Communications, 11(1), 3791. https://doi.org/10.1038/s41467-020-17521-w Cite
Researchers presented a simple and minimally invasive fine-needle aspiration-based organoid culture technique using a variety of tumor types including gastrointestinal, thyroid, melanoma, and kidney.
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Vilgelm, A., Bergdorf, K., Wolf, M., Bharti, V., Shattuck-Brandt, R., Blevins, A., Jones, C., Phifer, C., Lee, M., Lowe, C., Hongo, R., Boyd, K., Netterville, J., Rohde, S., Idrees, K., Bauer, J. A., Westover, D., Reinfeld, B., Baregamian, N., … Weiss, V. L. (2020). Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101408 Cite
Scientists developed expandable ovarian cancer organoids in less than three weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumors.
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Nanki, Y., Chiyoda, T., Hirasawa, A., Ookubo, A., Itoh, M., Ueno, M., Akahane, T., Kameyama, K., Yamagami, W., Kataoka, F., & Aoki, D. (2020). Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing. Scientific Reports, 10(1), 12581. https://doi.org/10.1038/s41598-020-69488-9 Cite
The authors report a method to generate ureteric bud organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis.
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The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
[Cell Death & Disease]
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Scientists established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma (LADC). Extensive gene and histopathology profiling show that the tumor organoids retain the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
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Estrogen receptor positive breast cancer organoids and aromatase inhibitor (AI)- or fulvestrant-resistant breast cancer cells were more sensitive to anastrozole plus estradiol than to AI alone.
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Cairns, J., Ingle, J. N., Dudenkov, T. T. M., Kalari, K. R., Carlson, E. E., Na, J., Buzdar, A. U., Robson, M. E., Ellis, M. J., Goss, P. E., Shepherd, L. E., Goodnature, B., Goetz, M. P., Weinshilboum, R. M., Li, H., Bari, M. G., & Wang, L. (2020). Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action. JCI Insight. https://doi.org/10.1172/jci.insight.137571 Cite