Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma-Brain Organoid Interfaces

May 13, 2026

[Advanced Healthcare Materials] Scientists presented a bioengineered assembloid system that integrates glioblastoma cells encapsulated in self-degradable 5% oxidized alginate microgel with dorsal forebrain organoids to recapitulate early tumor-host interactions during glioblastoma invasion toward the brain.

Accelerating Leigh Syndrome Drug Discovery through Deep Learning Screening in Brain Organoids

April 30, 2026

[Nature Communications] Researchers highlighted azoles as promising candidates for Leigh and demonstrate the potential of combining in silico screens with human brain organoids as new approach methodologies

Retinoic Acid Drives Cell Fate Specification, Maturation, and Retinal Regionality in Human Retinal Organoids

April 30, 2026

[Nature Communications] Scientists showed that temporal and dosage-dependant modulation of retinoic acid during human retinal organoid differentiation induces distinct changes in retinal cell abundance, maturation, and organisation.

Patient-Derived Pediatric Brain Tumor Orthotopic Xenografts and Tumor Organoids Faithfully Recapitulate Primary Tumors

April 30, 2026

[Science Advances] Investigators described the establishment of tumor organoid (TO) and TO xenografts from patient-derived orthotopic xenografts of medulloblastoma, embryonal tumor with multilayer rosettes, and atypical teratoid rhabdoid tumors.

Modeling Medulloblastoma Pathogenesis and Treatment in Human Cerebellar Organoids

April 30, 2026

[Genes & Development] Using c-MYC overexpression as an initiating oncogenic event, researchers demonstrated that these lineage-restricted progenitors are susceptible to neoplastic transformation, generating tumors with group 3 medulloblastoma molecular features in vitro and in vivo.

Automated and Scalable Expansion of Human Liver Organoids for Translational Applications

April 30, 2026

[Journal of Translational Medicine] Investigators presented a novel strategy using an automated bioreactor platform that enables large-scale expansion of human liver organoids.

Induction of Fibrosis in Human Kidney Organoids Delineates Mechanisms and Therapeutic Targets of Fibrotic Kidney Disease

April 30, 2026

[Stem Cell Research & Therapy] Three-dimensional self-organizing kidney organoids containing nephrons and stromal cells were exposed to TGF-β1 cytokine to induce fibrotic remodeling.

Modeling Gliomas with Organoids: Classification, Fidelity, and Guidelines for Translational Neuro-Oncology

April 30, 2026

[Neuro-Oncology] Scientists provide a comprehensive overview of the spectrum of glioma organoid models, recognizing that different systems offer distinct and complementary strengths, and offer practical guidance for selecting appropriate models and analytical readouts based on specific basic and translational research objectives.

Bottom-Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

April 16, 2026

[Advanced Materials] A bottom-up biomaterial-based platform was introduced to program cell state changes in pancreatic cancer organoids by tuning minimal adhesion cues within a synthetic matrix.

Pre-Adaptation of Stem Cell-Derived Islet Organoids to Hypoxia via Zinc Transportation Inhibition Drives Angiogenesis

April 16, 2026

[Cell Stem Cell] The authors demonstrated that chemical inhibition of zinc transportation boosts stem cell-derived islet organoids functional competence, offering a potential strategy to advance pre-adaptation to stress in regenerative medicine.

Early Differential Impact of MeCP2 Mutations on Functional Networks in Rett Syndrome Patient-Derived Human Cortical Organoids

April 16, 2026

[Nature Communications] Researchers focused on neuronal activity in Rett syndrome patient-derived organoids, analyzing two types of MECP2 mutations—a missense mutation and a truncating mutation —using calcium imaging with three-photon microscopy.

Patient-Derived Kidney Organoids Recapitulate ADPKD and Facilitate the Identification of Rho Pathway Inhibitors As Candidate Therapeutics

April 16, 2026

[Cell Reports Medicine] Scientists established expandable, multi-lineage adult renal organoids directly from surgical specimens of autosomal-dominant polycystic kidney disease (ADPKD) patients and healthy donors, creating a three-dimensional high-content screening platform.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.