Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Choroid Plexus Defects in Down Syndrome Brain Organoids Enhance Neurotropism of SARS-CoV-2

[Science Advances] Scientists demonstrated that the choroid plexus (ChP)-like epithelium facilitated infection and replication of SARS-CoV-2 in cortical neurons and that this is increased in Down syndrome (DS) established brain organoids from DS and isogenic euploid iPSC that consist of a core of functional cortical neurons surrounded by a functional ChP-like epithelium.

iPSC-Derived Hindbrain Organoids to Evaluate Escitalopram Oxalate Treatment Responses Targeting Neuropsychiatric Symptoms in Alzheimer’s Disease

[Molecular Psychiatry] Researchers generated hindbrain organoids containing serotonergic neurons using hiPSCs. They laid the groundwork for the application of hindbrain organoids to evaluate individual differences in disease progression, neuropsychiatric symproms development, and pharmacological treatment response.

Characterization of Patient-Derived Intestinal Organoids for Modelling Fibrosis in Inflammatory Bowel Disease

[Inflammation Research] Scientists induced and characterized an inflammation-mediated fibrosis in patient-derived organoids issued from crypts isolated from colonic mucosal biopsies of inflammatory bowel disease pediatric patients and age matched-control subjects.

Melatonin and Resveratrol Alleviate Molecular and Metabolic Toxicity Induced by Bisphenol A in Endometrial Organoids

[Reproductive Toxicology] Investigators comprehensively characterized the morphological, molecular and metabolic responses of porcine endometrial organoids to bisphenol A and assessed the potential protective effects of melatonin and resveratrol.

Interferon-γ Induces Combined Pyroptotic Angiopathy and APOL1 Expression in Human Kidney Disease

[Cell Reports] Using human kidney organoids, primary endothelial cells, and patient samples, researchers demonstrated that IFN-γ induced pyroptotic angiopathy in combination with APOL1 expression.

EGFR and HER2 Hyper-Activation Mediates Resistance to Endocrine Therapy and CDK4/6 Inhibitors in ER+ Breast Cancer

[Cancer Letters] Cetuximab treatment overcame tumor resistance to fulvestrant and abemaciclib in FAR and EGFR-overexpressing breast cancer spheroids and xenografts. Likewise, patient-derived organoids from individuals with ER + mBC, progressing on palbociclib, exhibited up-regulation of EGFR and HER2 pathways.

Enhancing IgA-Mediated Neutrophil Cytotoxicity Against Neuroblastoma by CD47 Blockade

[Journal For Immunotherapy of Cancer] In vitro killing assays showed enhanced IgA-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) by neutrophils targeting neuroblastoma cell lines and organoids in comparison to IgG. Notably, when combined with CD47 blockade, both IgG and IgA therapy were enhanced, though the combination with IgA resulted in the greatest improvement of ADCC.

Hepatic Spheroid-on-a-Chip: Fabrication and Characterization of a Spheroid-Based in Vitro Model of the Human Liver for Drug Screening Applications

[Biomicrofluidics] Researchers demonstrated an innovative microfluidic device for the formation, culture, and testing of hepatocyte spheroids, which comprises a large array of patterned microwells for hosting hepatic spheroid culture in a reproducible and organized format in a dynamic fluidic environment.

Wnt/β-Catenin Signaling Is a Therapeutic Target in Anaplastic Thyroid Carcinoma

[Endocrine] Scientists identified whether Wnt inhibitors could be potential therapeutic agents for anaplastic thyroid carcinoma (ATC) patients with limited treatment options. They used 4 ATC spheroid cell lines and two primary patient-derived ATC organoid cultures.

A Novel Thin Plate Spline Methodology to Model Tissue Surfaces and Quantify Tumor Cell Invasion in Organ-on-Chip Models

[Slas Discovery] Investigators applied an analytical approach to an adapted organ-on-chip developed by Emulate, Inc., utilizing a two-channel system with endothelial cells in the bottom channel and colorectal cancer patient-derived organoids in the top channel.

A Microfluidic Chip-Based Automated System for Whole-Course Monitoring the Drug Responses of Organoids

[Analytical Chemistry] Scientists a multifunctional microfluidic chip was developed to perform all procedures of organoid-based drug response tests, including establishment, culturing, drug treatment, and ATP monitoring of organoids. An ATP sensor was developed to facilitate the first successful attempt on whole-course monitoring the growth status of fragile organoids.

RUMI Scientific announces Receipt of Two-Year Phase II SBIR Award totaling $1.9 Million to Accelerate Discovery and Development of Novel Therapeutic Candidates for the...

[Rumi Scientific, Inc. (Globe Newswire)] RUMI Scientific, Inc. announced it has received a Phase II Small Business Innovation Research grant from the National Institutes of Mental Health totaling $1.9 MM. RUMI’s organoid platform utilizes an unbiased phenotypic approach to target drug discovery for CNS and other diseases.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.

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