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Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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Personalized Pharmacokinetic-Pharmacodynamic Guided Therapy via an Induced Pluripotent Stem Cell-Derived Multi-Organoid Platform in NF1-Mutant Breast Cancer
[Signal Transduction and Targeted Therapy] Investigators presented a personalized treatment model using a patient-derived Networking Organoid Culture System composed of intestinal, liver, and kidney organoids differentiated from iPSCs of an NF1-mutant breast cancer patient.
The Research Advances of Crosstalk between Cancer-Associated Fibroblasts and Tumor Cells Using Co-Culture Organoids
[Cell Death & Disease] The authors recapitulate the proposed methods for cultivating organoids consisted of tumor cells and cancer-associated fibroblasts (CAFs) as well as molecular mechanisms involving in regulating variety of CAF subgroups.
Brain Organoids in Environmental Neurotoxicology: Applications, Mechanisms, and Future Perspectives
[Cell Biology and Toxicology] Scientists explore the utility of brain organoids in environmental neurotoxicology, which address critical limitations of traditional models by recapitulating key aspects of human brain development, including 3D cytoarchitecture, multilineage cellular heterogeneity, and functional network activity.
The Emergence of Multiple Testicular Cell Lineages in Human Stem Cell-Derived Testis-Like Organoids
[Development] Researchers provided the first comprehensive transcriptional profile of hiPSC-derived testis-like organoids.
Advanced Human Organoid-on-Chip with Physiological Cellular Complexity Reveals Bidirectional Secretion Patterns
[Iscience] To understand how different epithelial cell types and external stimuli shape the asymmetric secretion of immune regulators, researchers established and characterized a human intestinal organoid-on-chip model.
Greenstone Biosciences and Neolaia Bio Announce Strategic Collaboration Using iPSC-Derived Macrophages and Human Gut Organoids to Advance IBD Drug Development
[Greenstone Biosciences (BioSpace)] Greenstone Biosciences announced a strategic collaboration with Neolaia Bio, who provide its proprietary drug candidates and discovery expertise, while Greenstone Biosciences will evaluate these compounds using hiPSC-derived macrophages and patient-relevant gut organoid models.
comBO: A Combined Human Bone and Lympho-Myeloid Bone Marrow Organoid for Preclinical Modeling of Hematopoietic Disorders
[Cell Stem Cell] Investigators introduced combined bone and lympho-myeloid bone marrow organoid (comBO), a scalable iPSC-derived system that generated osteolineage, vascular, lymphoid, and myeloid compartments within a single organoid.
Pulmonary Organoid Models Demonstrate Compositionally Driven Epithelial Plasticity and Immune Polarization
[iScience] The authors presented a lung organoid model that varies immune, epithelial, and mesenchymal inputs to reveal how composition dictates epithelial plasticity and macrophage polarization.
Human Microglia in Brain Assembloids Display Region-Specific Diversity and Respond to Hyperexcitable Neurons Carrying SCN2A Mutation
[Science Advances] Scientists developed hiPSC–derived organoid and assembloid models integrated with microglia, allowing in-depth exploration of microglial heterogeneity and neuroimmune interactions in human cell–based models.
Multi-Lineage Hepatic Organoids Reveal Toxic Exosome Mediated Indirect Hepatotoxicity
[Nature Communications] Investigators constructed 3D multi-lineage hepatic organoids comprising five liver cell types derived from hESCs, and in a screen of 58 hepatotoxic drugs, identified imipramine as an inducer of indirect hepatotoxicity.
Establishing Mouse Forebrain Organoids As Models of Intrinsic Cortical Network Assembly
[Stem Cell Reports] Scientists generated dorsal and ventral forebrain organoids from mPSCs and tracked their development using longitudinal electrophysiology.
Immune-Instructive Bone Organoids via Non-Immunogenic Plant-Based Bioinks for Enhanced Bone Repair
[Matter] Scientists proposed a non-immunogenic, xeno-free, and cytokine-free plant-derived bioink composed of aloe vera gel, laponite nanoclay, and gelatin methacrylate for constructing immune-instructive bone organoids.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
