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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Accessible Homeostatic Gastric Organoids Reveal Secondary Cell Type-Specific Host-Pathogen Interactions in Helicobacter pylori Infections
[Nature Communications] Investigators introduced a patterned homeostatic human gastric organoid-on-a-chip system with bilateral access that was capable of modeling H. pylori niche establishment and persistent colonization of the gastric epithelium.
Nephron Progenitor Fate Is Modulated by Angiotensin Type 1 Receptor Signaling in Human Kidney Organoids
[Stem Cells] To explore how angiotensin type 1 receptor (AT1R) signaling modulated nephron progenitor fate specification, researchers used iPSC derived human kidney organoids treated with angiotensin II or the AT1R blocker losartan during differentiation.
m6A Deficiency Impairs Hypothalamic Neurogenesis of Feeding-Related Neurons in Mice and Human Organoids and Leads to Adult Obesity in Mice
[Cell Stem Cell] Researchers showed that deletion of m6A writer Mettl14 in the mouse embryonic hypothalamus led to adult obesity, with impaired glucose-insulin homeostasis and increased energy intake.
Recapitulating Hypoxic Metabolism in Cartilaginous Organoids via Adaptive Cell-Matrix Interactions Enhances Histone Lactylation and Cartilage Regeneration
[Nature Communications] Scientists engineered a cell-adaptable supramolecular hydrogel that accommodated the extensive volumetric and morphological changes of encapsulated mesenchymal stromal cells, facilitating the rapid formation of large multicellular cartilaginous organoids.
Establishment and Molecular Characterization of Patient-Derived Organoids for Primary Central Nervous System Lymphoma
[Leukemia] Investigators developed a culture method for patient-derived primary central nervous system lymphoma organoids and evaluated the organoids through extensive molecular characterisation, histopathological analysis, single-nucleus RNA sequencing, bulk RNA sequencing and whole-exome sequencing.
Vascular Network-Inspired Diffusible Scaffolds for Engineering Functional Midbrain Organoids
[Cell Stem Cell] Investigators presented vascular network-inspired diffusible scaffolds to mimic physiological diffusion physics for generating functional organoids and phenotyping their drug response.
Ethical Considerations for Advancing Research Using Organoid Models Derived from the Placenta
[Human Reproduction Update] The authors offer valuable insights into the ethical landscape surrounding the derivation of tissues or products from pregnancies, and their further application, highlighting areas that require attention and discussion within both the scientific community and the broader society.
Comprehensive Genomic Dependency Landscape of a Human Colon Cancer Organoid
[Communications Biology] Scientists comprehensively characterized genetic dependencies present in a colon cancer organoid avatar, and validated tumor-specific selectivity of select pharmacologic agents.
Dynamic Culture System Advances the Applications of Breast Cancer Organoids for Precision Medicine
[Scientific Reports] Researchers developed a fluid system that built on the conventional organoid “dome” culture method, which continuously and stably supplied the nutrients for the growth of breast cancer organoids.
Unveiling Radiobiological Traits and Therapeutic Responses of BRAFV600E-Mutant Colorectal Cancer via Patient-Derived Organoids
[Journal of Experimental & Clinical Cancer Research] The authors harnessed the fidelity of patient-derived organoids to dissect the molecular landscape of radiosensitivity, with a particular emphasis on BRAFV600E mutations.
High-Dimensional Signaling Analysis of Organoids
[Current Opinion in Cell Biology] Scientists review the recent advances in high-dimensional analysis of cell signalling in organoids. Single-cell technologies provide cell-type specific analysis of multiple biochemical modalities, enabling a deeper understanding of the signalling mechanisms driving cell-fate dynamics.
A Skin Organoid-Based Infection Platform Identifies an Inhibitor Specific for HFMD
[Nature Communications] Scientists used hiPSC-derived skin organoids as a model for EV-A71 infection and found that multiple cell types within the skin organoids, including epidermal cells, hair follicle cells, fibroblasts, and nerve cells, expressed EV-A71 receptors and were susceptible to EV-A71 infection.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
