Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

A TLR7-Nanoparticle Adjuvant Promotes a Broad Immune Response against Heterologous Strains of Influenza and SARS-CoV-2

[Nature Materials] Researchers describe a polymeric Toll-like receptor 7 agonist nanoparticle (TLR7-NP) adjuvant, which enhanced lymph node targeting, and lead to persistent activation of immune cells and broad immune responses. They tested responses to this TLR7-NP using human tonsil organoids, and other methods.

ERC Proof of Concept Grant for Mina Gouti

[Max Delbrück Center] Organoids have to be fed and cared for continuously so that they can mature. So far, it is mostly a manual process – not suitable for industrial drug screening. Now, the European Research Council (ERC) has awarded Mina Gouti a Proof of Concept Grant to tackle scalability and reproducibility.

Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells

[European Journal Of Medicinal Chemistry] Investigators reported the discovery of a series of new AXL PROTAC degraders. One representative compound 6n potently depleted AXL with a DC50 value of 5 nM in MDA-MB-231 TNBC cells.

Preclinical Patient-Derived Modeling of Castration-Resistant Prostate Cancer Facilitates Individualized Assessment of Homologous Recombination Repair Deficient Disease

[Molecular Oncology] In vitro, castration-resistant prostate cancer (LNCaP) sublines revealed a homologous recombination repair defect and enhanced sensitivity to olaparib and cisplatin due to impaired RAD51 expression and recruitment.

Antibody-Exatecan Conjugates with a Novel Self-Immolative Moiety Overcome Resistance in Colon and Lung Cancer

[Cancer Discovery] The authors designed an antibody-drug conjugates class using a novel self-immolative T moiety for traceless conjugation and release of exatecan, a more potent Topoisomerase I inhibitor with less sensitivity to multidrug resistance.

Polyamine Metabolism Impacts T Cell Dysfunction in the Oral Mucosa of People Living with HIV

[Nature Communications] Mechanistic studies using an in vitro human tonsil organoid infection model revealed that HIV infection of T cells resulted in increased polyamine synthesis, which was dependent on the activities of caspase-1, IL-1β, and ornithine decarboxylase-1.

Using Patient-Derived Organoids to Predict Locally Advanced or Metastatic Lung Cancer Tumor Response: A Real-World Study

[Cell Reports Medicine] Researchers generated 214 cancer organoids from 107 patients, of which 212 are lung cancer organoids , primarily derived from malignant serous effusions.

USP7 Inactivation Suppresses APC-Mutant Intestinal Hyperproliferation and Tumor Development

[Stem Cell Reports] Scientists showed in vivo that deletion of Usp7 in Apc-truncated mice inhibits crypt hyperproliferation and intestinal tumor development.

CDK1 Bridges NF-κB and β-Catenin Signaling in Response to H. pylori Infection in Gastric Tumorigenesis

[Cell Reports] CDK1 phosphorylated and inhibited GSK-3β activity through direct binding with subsequent accumulation and activation of β-catenin. CDK1 silencing or pharmacologic inhibition reversed these effects and impairs tumor organoids and spheroid formation.

Human iPSC-Derived Preclinical Models to Identify Toxicity of Tumor-Specific T Cells with Clinical Potential

[Molecular Therapy-Methods & Clinical Development] Preclinical models with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, epicardial cells, and kidney organoids to investigate toxicity risks of tumor-specific T cells more thoroughly.

Towards a Better Understanding of Diabetes Mellitus Using Organoid Models

[Nature Reviews Endocrinology] The authors review organoid models for studying diabetes mellitus and provide insights into development, hormones and glucose toxicity effects in the pancreas and other organs.

Bone/Cartilage Organoid On-Chip: Construction Strategy and Application

[Bioactive Materials] Scientists propose the concept of bone/cartilage organoid on-chip platform, and summarize the basic modules and current efforts to orchestrate them on a single microfluidic system.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.

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