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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Evaluating Neuroprivacy Concerns in Human Brain Organoid Research
[Trends In Biotechnology] The authors explored the implications of neuroprivacy in human brain organoid research, detailing different interpretations of this right.
Induced Pluripotent Stem Cell-Derived Parathyroid Organoids Resemble Parathyroid Morphology and Function
[Advanced Science] Investigators parathyroid organoids were successfully generated from hiPSCs. At the end of the 20 days of differentiation, the parathyroid organoids exhibited distinct parathyroid morphology.
Targeting ALDH1A1 to Enhance the Efficacy of KRAS-Targeted Therapy through Ferroptosis
[Redox Biology] KRAS inhibitors' efficacy was significantly improved in sensitive or drug-resistant cells, patient-derived organoids, and xenograft models by ALDH1A1 knockout, loss of enzyme function, or inhibitor.
Tuft Cells Act As Regenerative Stem Cells in the Human Intestine
[Nature] By combining analysis of primary human intestinal resection material and intestinal organoids, the authors identified four distinct human tuft cell states, two of which overlap with their murine counterparts.
CALB2 Drives Pancreatic Cancer Metastasis through Inflammatory Reprogramming of the Tumor Microenvironment
[Journal of Experimental & Clinical Cancer Research] Co-culture systems containing cancer-associated fibroblasts (CAFs) and patient-derived organoids in vitro and in vivo were employed to elucidate the effects of CALB2-activated CAFs on pancreatic ductal adenocarcinoma malignancy.
Establishment of Goat Mammary Organoid Cultures Modeling the Mammary Gland Development and Lactation
[Journal of Animal Science and Biotechnology] Scientists developed a protocol to established a culture system for mammary organoids in dairy goats to model the mammary gland development and lactation process.
IFNγ Induces Epithelial Reprogramming Driving CXCL11-Mediated T Cell Migration
[Journal of Leukocyte Biology] Using a 3D co-culture system based on human intestinal epithelial organoids, scientists explored the capacity of IFNγ-exposure to reprogram intestinal epithelia and thereby directly modulate lymphocyte responses.
Non-Invasive Label-Free Imaging Analysis Pipeline for In Situ Characterization of 3D Brain Organoids
[Scientific Reports] Enabled by a microfluidic-based culture of 3D cell systems and a novel 3D quantitative phase imaging method, investigators demonstrated the ability to perform non-destructive high-resolution quantitative image analysis of the organoid.
Human Trophoblast Organoids for Improved Prediction of Placental ABC Transporter-Mediated Drug Transport
[Toxicology and Applied Pharmacology] Researchers trophoblast organoids were cultured from human placental villi and developed into three-dimension structures with cavities. Trophoblast organoids exhibited transporter expression and localization comparable to that in villous tissue, indicating their physiological relevance for modeling drug transport.
Novel Human iPSC Models of Neuroinflammation in Neurodegenerative Disease and Regenerative Medicine
[Trends In Immunology] The authors review new advancements in the differentiation of hiPSCs into glial, neural, and blood–brain barrier cell types, and the integration of these cells into complex organoids and chimeras.
NIH Awards $7.5 Million to Ankur Singh for Pioneering Human Immune Organoid Research
[Georgia Tech] The National Institutes of Health (NIH) has awarded $7.5 million to Ankur Singh, Carl Ring Family Professor in the George W. Woodruff School of Mechanical Engineering and professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory, for his pioneering research in creating functional models of the human immune system in the lab.
Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids
[Journal of Medicinal Chemistry] Researchers designed a series of dual LSD1-HDAC inhibitors. One of those compounds demonstrate significant antitumor activity against colorectal cancer, better than irinotecan, and effectively inhibits growth in patient-derived colorectal cancer organoids.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
