Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Phototoxicity Avoidance Is a Potential Therapeutic Approach for Retinal Dystrophy Caused by EYS Dysfunction

[JCI Insight] Scientists generated retinal organoids from iPSCs derived from patients with eyes shut homolog (EYS)-associated retinal dystrophy.

LPA5-Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation

The effects of lysophosphatidic acid (LPA)5 on intestinal stem cells were corroborated by studies using organoids derived from Lgr5-lineage tracking reporter mice with deletion...

Combination of Bazedoxifene with Chemotherapy and SMAC-Mimetics for the Treatment of Colorectal Cancer

Researchers provided evidence that bazedoxifene inhibited tumour growth via direct interaction with the gp130 receptor to suppress IL-6 and IL-11-mediated STAT3 signalling. Additionally, bazedoxifene...

Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons

[Nature Communications] To understand the mechanistic significance of inter-regional projections on development of neural circuits, researchers investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.

Intestinal Inflammation Marker Calprotectin Regulates Epithelial Intestinal Zinc Metabolism and Proliferation in Mouse Jejunal Organoids

[Biomedicine & Pharmacotherapy] Scientists aimed to characterize the effect of calprotectin on mouse jejunal organoids as a model epithelium, focusing on Zn2+ metabolism and cell proliferation.

Modeling HIV-1 Infection and NeuroHIV in hiPSCs-Derived Cerebral Organoid Cultures

[Journal Of Neurovirology] Researchers generated and characterized several human-induced pluripotent stem cell lines from healthy human donor skin fibroblast cells. hiPSCs were then used for the generation of microglia-containing human cerebral organoids.

Generation of Human Cerebral Organoids with a Structured Outer Subventricular Zone

[Cell Reports] Scientists indicated that increasing the cellular complexity of the organoid microenvironment promoted the emergence of oRG and supported a platform to study the outer radial glia in human pluripotent stem cells-derived brain organoids routinely.

Evaluation of EGFR and COX Pathway Inhibition in Human Colon Organoids of Serrated Polyposis and Other Hereditary Cancer Syndromes

[Familial Cancer] Researchers examined the effects of EGFR and COX pathway inhibition in organoid cultures derived from uninvolved colon and polyps of serrated polyposis syndrome patients. They also compared with organoids representing the hereditary gastrointestinal syndromes, Familial Adenomatous Polyposis and Lynch syndrome.

RFX6 Regulates Human Intestinal Patterning and Function Upstream of PDX1

[Development] To identify how mutations in RFX6 impacted intestinal patterning and function, investigators derived iPSCs from this patient to generate human intestinal organoids.

A Bioactive Calcium Silicate Nanowire-Containing Hydrogel for Organoid Formation and Functionalization

[Materials Horizons] Scientists explored the potential of a composite hydrogel mainly consisting of calcium silicate nanowires and methacrylated gelatin as a substrate for organoid formation and functionalization, specifically for intestinal and liver organoids.

Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction

[Biomaterials Research] Beginning with the basic concepts of organoids, the authors describe strategies for cultivating engineered organoids and discuss the multiple engineering modes to create conditions for breakthroughs in organoid research.

Uncharted Territory: Ethical Questions Cloud Fetal Brain Organoid Research

[Brain Tomorrow] A new development, termed fetal brain organoids or FeBOs, offers an unprecedented opportunity to study the intricate processes of early brain development. However, it also raises complex ethical and legal questions that demand careful consideration.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.