Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

E-Cadherin Loss Drives Diffuse-Type Gastric Tumorigenesis via EZH2-Mediated Reprogramming

[Journal Of Experimental Medicine] Researchers discovered CDH1 inactivation in a subset of diffuse-type gastric adenocarcinoma (DGAC) patient tumors. Analyzing single-cell transcriptomes in malignant ascites, they identified two DGAC subtypes: DGAC1 (CDH1 loss) and DGAC2 (lacking immune response).

Deciphering Fibroblast-Induced Drug Resistance in Non-Small Cell Lung Carcinoma through Patient-Derived Organoids in Agarose Microwells

[Lab On A Chip] Investigators introduced an agarose microwell platform designed for patient-derived organoid-based tumor and tumor microenvironment models, enabling rapid drug screening and resistance studies with small sample volumes.

SOX2 and OCT4 Mediate Radiation and Drug Resistance in Pancreatic Tumor Organoids

[Cell Death Discovery] Investigators treated pancreatic tumor organoids with 4 or 8 Gy of radiation, 10 μM of 5-Fluorouracil, and 100 μM 3-Bromopyruvate, a promising anti-cancer drug, as a single treatment modalities, and in combination with RT.

The Benefits of Stem Cell Biology and Tissue Engineering in Low-Earth Orbit

[Stem Cells And Development] Investigators underscore the potential benefits of microgravity on fundamental stem cell properties, highlighting the adaptability of cells to their environment and emphasizing physical stimuli as a key factor influencing cultured cells.

PTCH1-Mutant Human Cerebellar Organoids Exhibit Altered Neural Development and Recapitulate Early Medulloblastoma Tumorigenesis

[Disease Models & Mechanisms] Investigators used cerebellar organoids differentiated from hiPSCs combined with CRISPR/Cas9 gene editing to investigate the earliest molecular and cellular consequences of Patched 1 (PTCH1) mutations on human cerebellar development.

Prediction for Oxaliplatin-Induced Liver Injury Using Patient-Derived Liver Organoids

[Cancer Medicine] Scientists examined the relationship between the clinical signs of oxaliplatin-induced liver injury and the responses of patient-derived liver organoids in vitro.

Effect of Estradiol after Bacterial Infection on the Wnt/β-Catenin Pathway in Bovine Endometrium Epithelial Cells and Organoids

[Theriogenology] Researchers presented the techniques for isolating and culturing primary bovine endometrial epithelial cells, and producing endometrial organoids.

Comparing Stem Cells, Transdifferentiation, and Brain Organoids as Tools for Psychiatric Research

[Translational Psychiatry] The authors contrast advantages and disadvantages of each of these six cell-based methodologies. Neuronal-like cells derived from pluripotent monocytes are presented in more detail as this technique was recently used in psychiatry for the first time.

UC Irvine Advances Stem Cell Research with $4 Million CIRM Grant for Shared Resources Lab

[UCI News] The University of California, Irvine (UCI) received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center. The facility will offer essential technologies and training for the development of novel in vitro stem cell-based modeling that will serve researchers across the campus and the state.

A Pair of Primary Colorectal Cancer-Derived and Corresponding Synchronous Liver Metastasis-Derived Organoid Cell Lines

[Aging-Us] The authors presented paired 3D organoid cell lines of CWH22 and CLM22 with sound background information and the short tandem repeats were identical to those of the normal tissue.

Advanced Lung Organoids for Respiratory System and Pulmonary Disease Modeling

[Journal of Tissue Engineering] Scientists introduce recent progress in the production methods of lung organoids, strategies for improving maturity, functionality, and complexity of organoids, and their application in disease modeling, including respiratory infection and pulmonary fibrosis.

A Human Lymphoma Organoid Model for Evaluating and Targeting the Follicular Lymphoma Tumor Immune Microenvironment

[Cell Stem Cell] The authors described an organoid culture method for cultivating patient-derived lymphoma organoids, which included cells from the native follicular lymphoma tumor microenvironment.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.