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Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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Miriam Filippi receives IEEE EMBS Early Career Achievement Award 2026
[Eidgenössische Technische Hochschule Zürich] Miriam Filippi, Senior Researcher at the Soft Robotics Lab in the Department of Mechanical and Process Engineering, has been awarded the IEEE EMBS Early Career Achievement Award 2026.
Progressing Regenerative Medicine: Integrating Bioprinting Platforms for Stem Cell Applications
[Stem Cell International] Investigators critically evaluate bioprinting strategies tailored for stem cell applications, including the selection of stem cell sources, bioink formulation, crosslinking methodologies, and dynamic culture systems.
AcroCyte Therapeutics Awarded ARPA ‑H Funding to Advance Scalable Human Organoid Technologies
[AcroCyte Therapeutics, Inc.] AcroCyte Therapeutics Inc. today that it has been selected to receive funding from the Advanced Research Projects Agency for Health (ARPA‑H) to advance scalable human organoid technologies for regenerative medicine applications.
Mapping Mesenchymal Diversity in the Human Small Intestine and Organoids
[Nature Cell Biology] Investigators leveraged single-cell RNA-sequencing data to build a Xenium spatial transcriptomics gene panel covering the cell diversity of the human small intestine. They leveraged this high-resolution atlas to interrogate cell–cell signaling and benchmark PSC-derived human intestinal organoids.
Subcutaneous Transplantation of Lung Organoids Ameliorates Vascular Dementia via the IGFBP7-Ago2 Mediated Lung-Brain Axis
[Journal of Neuroinflammation] Scientists demonstrated that subcutaneous transplantation of lung organoids ameliorated cognitive dysfunction in a mouse model of bilateral common carotid artery stenosis.
Patient-Derived Decidual Organoids Reveal Rhg-CSF-Associated Protective Responses Involving JAK2/STAT3 Signaling in Recurrent Spontaneous Abortion
[Stem Cell Research & Therapy] Scientists established a patient-derived decidual organoid model. In this in vivo recurrent spontaneous abortion model, recombinant human granulocyte colony-stimulating factor (rhG-CSF) exerted protective effects by promoting proliferation, inhibiting apoptosis, and enhancing angiogenesis.
Emergence of Disease-Relevant Aberrant Epithelial Cell States in Human Alveolar Organoids
[American Journal of Respiratory Cell and Molecular Biology] The authors investigated how primary human alveolar epithelial organoids respond to a commonly-used commercial alveolar differentiation media intended to facilitate AT2->AT1 differentiation in isolation and following biased hypoxia-inducible factor 2 activation.
Modeling Tonsil Organoids for Studying Mucosal Immune Responses to SARS-CoV-2 Vaccination
[Tissue Barriers] Researchers established a novel human tonsil organoid platform and stimulated it with the chimpanzee adenovirus serotype 68-19 spike protein SARS-CoV-2 vaccine candidate.
Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction
[Cellular and Molecular Neurobiology] Using cerebral organoids derived from hiPSCs carrying the familial PSEN1 A246E variant, researchers investigated the temporal relationship between amyloid-β dysregulation and spontaneous neuronal activity.
Bioengineering Advances in Pancreatic Cancer Organoids for Reproducible Tumor Microenvironment Modeling
[Iscience] Patient-derived organoids (PDOs) have emerged as efficient model platforms for simulating the tumor microenvironment and preserving tumor heterogeneity and enabling functional testing in vitro. The authors synthesize recent bioengineering advances that upgrade pancreatic cancer PDO platforms.
Human Organoids As Drug Development Tools for Polycystic Kidney Disease
[Nephron] Investigators review important achievements, current limitations, and future strategies, with a focus on translational ‘bench to bedside’ potential of polycystic kidney disease organoids as drug development tools.
Human BBB-Brain Organoid on a Millifluidic Plate for Modeling Brain Parenchymal Pathology-Induced Barrier Dysfunction
[Journal of Advanced Research] Researchers developed an integrated human blood–brain barrier (BBB)-brain organoid-on-a-chip model that replicates physiological interaction and pathological disruption between the BBB and brain parenchyma.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
