Keep Current with the Latest in Cell Biology Research
Investigators used a combination of in vivo postpartum breast cancer models and in vitro assays to study the effects of inactivation of the MNK1/2-eIF4E axis on the pro-tumor function of select cells of the TME
6445212 5HBEJTTF items 1 apa default asc 1
The authors discuss extracellular vesicle (EV) biology in 3D culture correlates of the tumor microenvironment (TME). This includes EV communication between cell types of the TME, differences in EV biogenesis and signaling associated with differing scaffold choices and in scaffold-free 3D cultures and cultivation of the premetastatic niche.
[International Journal of Molecular Sciences]
6445212 UBZA6G65 items 1 apa default asc 1
CSA Medical, Inc. announced that all subjects have been enrolled in the RejuvenAir® System study. The aim of this study is to determine the mechanism by which Metered CryoSpray reduces the density of goblet cells responsible for over-producing mucus and observe re-growth of healthy cilia in the airways.
[CSA Medical, Inc. (Cision US, Inc.)]
6445212 nan items 1 apa default asc 1
Scientists carried out a nested cohort study within a Phase IIa safety trial of treatment with allogeneic MSCs for moderate to severe ARDS.
6445212 RVJZRD8Q items 1 apa default asc 1
Biofunctional scaffolds were prepared by immobilizing mesenchymal stromal exosomes onto fibrous polyester materials and allowed cell-mediated delivery of membrane-bound vesicles.
6445212 8JW3XGDA items 1 apa default asc 1
The authors constructed fibroblast atlases by integrating single-cell transcriptomic data from about 230,000 fibroblasts across 17 tissues, 50 datasets, 11 disease states and 2 species.
6445212 JWHLK4AA items 1 apa default asc 1
Investigators conducted an in vitro chemical array screen and identified multiple small molecules that interacted with PSF. Several molecules inhibited RNA binding by PSF and decreased prostate cancer cell viability.
6445212 AR6SQIIF items 1 apa default asc 1
To characterize the regulatory logic of androgen receptor (AR)-mediated transcription, researchers generated a locus-specific map of enhancer activity by functionally testing all common clinical AR binding sites with Self-Transcribing Active Regulatory Regions sequencing.
6445212 RI6IZBC5 items 1 apa default asc 1
Researchers showed that the level of hyaluronic acid synthase 2 (HAS2) was positively correlated with the malignant phenotype of breast cancer cells. The increased expression of HAS2 promoted the invasive and migratory abilities of luminal breast cancer cells in vitro, followed by a reduced expression of E-cadherin, β-catenin, and ZO-1, and an elevated expression of N-cadherin and vimentin.
[Molecular and Cellular Biochemistry]
6445212 RGL736TV items 1 apa default asc 1
Scientists demonstrated that the expression levels of MDM2 proto‑oncogene, E3 ubiquitin protein ligase were markedly increased in TGF‑β‑induced epithelial‑to‑mesenchymal transition using quantitative PCR and western blotting.
The authors investigated the regulation of Serine protease 50 (TSP50) expression in breast cancer by predicting and analyzing miRNAs that could target TSP50 mRNA 3′UTR.
[DNA and Cell Biology]