[Ryvu Therapeutics] Ryvu Therapeutics annnounced that the first patient has been dosed in the JASPIS-01 study, a Phase II clinical trial investigating dapolsertib for the treatment of patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

[RNA Biology] Researchers performed a genome-wide polysome profiling analysis in sorafenib-treated HCC cells and demonstrated that, despite global translation repression, a set of different genes remained efficiently translated or were even translationally induced.

[Hepatology] Investigators confirmed that senescence markers and pathways were increasingly expressed in hepatocytes as alcohol-related liver disease progressed towards alcohol-associated hepatitis (AH); this was partially reversed following AH resolution.

[Nature Materials] Scientists reported that the anisotropy of stress fields was a critical factor triggering a phenotypic transition in fibroblast cells, outweighing the role of stress amplitude, a factor previously described to modulate such a transition.

[iScience] Researchers showed that PTBP1 and numb alternative splicing was critical for ECM stiffness induced epithelial cell spreading and proliferation as well as for mesenchymal stem cell differentiation into osteoblasts on a stiff matrix.

[Cell Reports] Investigators showed that TFE3 expression drove the metastatic phenotype in melanoma cell lines and tumors. Deletion of TFE3 in microphthalmia-associated transcription factor (MITF)-low melanoma cell lines suppressed their ability to migrate and metastasize.

[Journal of Translational Medicine] Investigators developed DMC-GF, a novel GLUT1-based curcumin derivative, to enhance brain specificity and metabolic stability compared to its predecessor DMC-BH.

[Stem Cell Research & Therapy] Scientists investigated a novel resistance mechanism involving glioblastoma stem cells and the polarization of M2-type macrophages, mediated by the extracellular vesicle-based transfer of Clusterin.

[Molecular Oncology] The susceptibility of the colon cancer circulating tumor cell (CTC)-derived cell line CTC-MCC-41 to AKT and mammalian target of rapamycin (mTOR) inhibitors was evaluated.

[Scientific Reports] The authors integratively performed DNA methylome and transcriptome combined with single-nucleus RNA sequencing to investigate DNA methylation and gene expression patterns of nasopharyngeal carcinoma and CSCs.

[World Journal of Clinical Oncology] Scientists investigated the role of Octamer transcription factor 4 in pancreatic CSCs and its effect on pancreatic cancer cell proliferation, migration, drug sensitivity, and stemness maintenance.

[Journal of the Egyptian National Cancer Institute] The authors provide insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfully.