Keep Current with the Latest in Cell Biology Research

CBX2 As a Therapeutic Target in Colorectal Cancer: Insights into the Altered Chromatin Accessibility via RUNX1-CBX2-MAP4K1 Axis

[Oncogene] Gain and loss of function studies demonstrated that chromobox homolog 2 (CBX2) significantly promoted colorectal cancer (CRC) progression and chemoresistance in cell lines, patient-derived CRC organoids and xenografts.

Allogeneic Stem Cell Transplant for Myelofibrosis and Myelodysplastic Syndromes: A Contemporary Review

[American Journal of Hematology] The authors provide a contemporary review on HSC transplantation for myelodysplastic neoplasms and myelofibrosis, highlighting up-to-date insights into disease biology, standard of care, and recommendations, as well as open avenues.

Genetic Variation Modulates Susceptibility to Aberrant DNA Hypomethylation and Imprint Deregulation in Naive Pluripotent Stem Cells

[Stem Cell Reports] Investigators showed that naive PSCs from inbred mouse strains exhibited strain-specific susceptibility to locus-specific deregulation of imprinting marks during reprogramming and upon exposure to a mitogen-activated protein kinase inhibitor, a common approach to maintain naive pluripotency.

Ground-State Pluripotent Stem Cells Are Characterized by Rac1-Dependent Cadherin-Enriched F-Actin Complexes Icon for the Forest of Biologists

[Journal of Cell Science] Scientists investigated how the actin cytoskeleton was regulated in different pluripotency states. They observed a drastic reorganization during the transition from ground-state naïve mESCs into converted prime epiblast stem cells.

Y Chromosome-Linked UTY Modulates Sex Differences in Valvular Fibroblast Methylation in Response to Nanoscale Extracellular Matrix Cues

[Science Advances] Scientists hypothesized that the lysine demethylase ubiquitously transcribed tetratricopeptide repeat containing Y-linked (UTY) decreased methylation uniquely in male valvular interstitial cells responding to nanoscale ECM cues to promote an osteoblast-like cell phenotype.

Adhesion-Assisted Antioxidant-Engineered Mesenchymal Stromal Cells for Enhanced Cardiac Repair in Myocardial Infarction

[ACS Nano] Investigators demonstrated that chemical modification of MSCs with anti-VCAM1 and polydopamine significantly enhanced MSC survival and promoted cardiac repair.

Melatonin Suppresses PD-L1 Expression and Exerts Antitumor Activity in Hepatocellular Carcinoma

[Scientific Reports] Researchers discovered that melatonin inhibited cancer cell proliferation, migration, and invasion, as well as reduced PD-L1 expression in cancer cells.

Aged and BRCA Mutated Stromal Cells Drive Epithelial Cell Transformation

[Cancer Discovery] Scientists reported that an epigenetically altered MSC niche, termed high risk MSC, existed prior to serous tubal intraepithelial carcinoma lesion formation.

KDM4B Modulates Autocrine IL6 in Erythroblasts to Prevent Ineffective Erythropoiesis

[Leukemia] Scientists found that the kdm4b−/− mutant zebrafish developed an ineffective erythropoiesis-like defect, including impaired terminal maturation and apoptosis of erythroblasts, as confirmed by observations in Kdm4b−/− mutant mice.

Adjuvant Aspirin Treatment in PIK3CA Mutated Colon Cancer Patients: The SAKK 41/13 – Prospective Randomized Placebo-Controlled Double-Blind Trial

[Clinical Cancer Research] Investigators assessed the benefit of adjuvant aspirin in resected PIK3CA-mutated colon cancer patients. Patients with resected colon cancer stage II and III harbouring an activating PIK3CA mutation were included.

Impact of Treatment for Adolescent and Young Adults with Essential Thrombocythemia and Polycythemia Vera

[Leukemia] This retrospective study of essential thrombocythemia and polycythemia vera patients diagnosed before age 25 evaluated complication rates and impact of cytoreductive drugs on outcomes.

Phase II Study of Neoadjuvant Durvalumab Plus Docetaxel, Oxaliplatin, and S-1 with Surgery, and Adjuvant Durvalumab Plus S-1 for Resectable Locally Advanced Gastric Cancer

[Journal For Immunotherapy of Cancer] This Phase II study evaluated the efficacy and safety of combining neoadjuvant durvalumab with docetaxel, oxaliplatin, and S-1, followed by surgery and adjuvant durvalumab plus S-1 chemotherapy, for resectable locally advanced gastric cancer.

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