[Cleveland Clinic] The Women’s Alzheimer’s Movement (WAM) at Cleveland Clinic awarded grants for three of the most promising research projects in the field of gut-brain interactions, menopause, and sarcopenia.

[Nature Communications] Researchers identified astrocyte-derived kynurenic acid (KYNA), a neuroactive metabolite known to modulate multiple neurotransmitter receptor systems, including the N-methyl-D-aspartate receptor (NMDA), as a mediator of cognitive dysfunction in the context of aberrant astrocyte activity.

[Nature Communications] Investigators reported a synthetic peptidomimetic foldamer, M4, as a potent modulator of amyloid-β (Aβ) 42 aggregation. Biophysical analyses demonstrate that M4 binds Aβ with high affinity, inhibits oligomer formation, and remodels pre-existing aggregates.

[Advanced Healthcare Materials] Scientists presented a bioengineered assembloid system that integrates glioblastoma cells encapsulated in self-degradable 5% oxidized alginate microgel with dorsal forebrain organoids to recapitulate early tumor-host interactions during glioblastoma invasion toward the brain.

[BJC reports] Researchers addressed the therapeutic relevance of glioblastoma (GBM)’s molecular characterization, focusing on whether a proneural-vs-mesenchymal classification may describe GBM heterogeneity, correlate to stemness and CD44, and have a prognostic value in terms of temozolomide resistance.

[Communications Biology] Investigators developed an integrative discovery strategy to identify natural compounds that mitigate endoplasmic reticulum (ER)-stress-associated phenotypes across cellular and organismal models.

[Communications Biology] Scientists reported the generation of hiPSC-derived cerebellar organoids that are characterized by induction of rhombomere 1 cellular identity and followed by derivation of typical neuronal and glial cell types of the cerebellum.

[Scientific Reports] Investigators hypothesised that immunogenic cell death or cGAS-STING pathway activation could be involved. They evaluated cell death, damage-associated molecular patterns, RT1a exposure, and cGAS-STING activation 24 h after irradiation.

[Discover Oncology] The authors provide a comprehensive overview of current knowledge on the role of cathepsins in glioblastoma biology.

[Journal of Nanobiotechnology] Investigators provided a basis for further development of combination immunotherapy strategies for poorly immunogenic breast cancer, including strategies to improve responses to checkpoint blockade.

[Molecular Therapy] With the goal of enhancing oncolytic virotherapy independently of E2, scientists designed a treatment strategy that combines oncolytic Vesicular stomatitis virus with the NF-κB inhibitors IKK16 and Sulfasalazine and found that both drugs improved virus replication in TNBC cell lines and patient samples.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that BRCA1P1 expression varies across multiple cancer cell types, with no significant association with BRCA1 or BRCA2 somatic mutations in breast and ovarian tumors.