[Small Methods] Researchers showed a tunable polyethylene glycol-based hydrogel system functionalized with RGD and HAVDI peptides to simulate varying matrix stiffness and N-cadherin ligation.

[Developmental Cell] Scientists showed that β cell dysfunction in type 2 diabetes patients and diabetic mice correlates with elevated nucleolar stress and reduced expression of BAF60C, a switching defective/sucrose nonfermenting chromatin-remodeling factor.

[Stem Cell Reports] Scientists presented a robust cell-sorting-based purification strategy to enhance stem cell-derived beta (SC-beta) cell purity. They identified CD133 as a beta cell-enriched surface marker capable of distinguishing SC-beta cells from SC-alpha cells.

[Cell Host & Microbe] Through 16S rDNA sequencing of PDAC tumors from 40 patients and screening of probiotic strains, investigators identified Bifidobacterium longum as capable of colonizing tumors and invading PDAC cells.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that in PDAC cell lines with amplified MYC, MondoA is required for viability, facilitating proliferation while suppressing apoptosis in vitro and in vivo.

[Cancer Science] Researchers found that circ-0030167 plays a critical regulatory role in mitophagy and ferroptosis in pancreatic cancer. Circ-0030167 enhanced the stability of IGFBP1 protein through direct molecular interaction.

[Apoptosis] The authors summarize recent advances in understanding mitochondria-associated programmed cell death in β cells and its contribution to type 2 diabetes mellitus (T2DM) pathophysiology.

[Uppsala University] Does autoimmunity play a role in the development of cancer? Why is it that some people with an increased risk of developing cancer never do? Dr. Nils Landegren is part of an international team of researchers that has been awarded the equivalent of SEK 225 million through the Cancer Grand Challenges research initiative to study this.

[University of Oklahoma] A $1.7 million grant from the National Institutes of Health will allow a University of Oklahoma researcher to continue investigating a protein that may help explain why lupus develops and how it might be treated more precisely.

[Blood] Recent data have led to a better understanding of the role of myeloid cells and T cells, including tissue-resident T-cells, in the pathophysiology of graft-versus-host disease, CAR-T cell associated immunotoxicities and immune-related adverse events.

[Signal Transduction and Targeted Therapy] Cytotoxic CD4+ T lymphocytes play pivotal roles across a broad spectrum of diseases, including cancer, infectious diseases, autoimmune disorders, and cardiovascular diseases.

[Cell] Investigators performed multi-omic profiling of 110 healthy participants through the ImmunoMicrobiome study. They generated multimodal data of the immune system, microbiome, and metabolome as a resource for the field.