[Nature Communications] Researchers showed that basal-like breast cancer harbouring the recurrent 9p21.3–9p24 amplicon, and particularly those that are homologous recombination-defective, overexpress Pumilio RNA binding family member 3.

[Science Advances] Researchers generated a multiplatform single-cell and spatial transcriptomic atlas, identifying male-specific tumor cells that were enriched in male breast cancer, rare in female breast cancer, and associated with poorer disease-free survival.

[Cancer Research] Investigators performed single-cell spatial transcriptomics on primary breast cancer and matched ipsilateral breast tumor recurrence (IBTR) specimens from patients to generate a comprehensive atlas of over 600,000 cells, delivering a high-resolution spatial landscape of IBTR.

[Cell Reports] Scientists reported that hyperglycemia stabilizes BRD4 protein, a bromodomain transcriptional coactivator recognizing histone lysine acetylation, to accelerate breast cancer growth.

[Cancer Letters] Investigators showed that Protein Arginine Methyltransferase 1 is highly expressed in breast cancer and forms a transcriptional activation complex with Y-box binding protein 1.

[JCI Insight] Researchers identified Notch-regulated biomarkers by conducting a pre-surgical window study evaluating endocrine therapy combined with the γ-secretase inhibitor (GSI) MK-0752 in estrogen receptor positive breast cancer.

[British Journal of Cancer] Researchers unveiled an ERα/heterogeneous nuclear ribonucleoprotein C (HNRNPC)/DDX6 axis in estrogen receptor positive breast cancer.

[EMBO Reports] The authors uncovered a previously undescribed post-translational mechanism by which cancer cells inactivate the potent mitochondrial tumor suppressor LACTB in breast cancers

[Biomarker Research] Scientists demonstrated a biomarker-driven approach to treating TNBC through polyamine depletion using TNBC cell lines, ex vivo tumor slices, and in vivo patient-derived xenograft models with low, moderate and high baseline levels of spermidine/spermine N1-acetlytransferase.

[Acta Pharmacologica Sinica] The authors demonstrated that ATPase H+ Transporting Accessory Protein 1 (ATP6AP1) enhances the malignant phenotype of breast cancer cells by upregulating X-linked inhibitor of apoptosis protein (XIAP) expression.

[Ecotoxicology and Environmental Safety] Researchers integrated network toxicology, molecular docking, and in vitro validation to systematically evaluate the potential effects of bisphenol A on estrogen-related tumors, including breast, ovarian, and endometrial cancers.

[Life Sciences] Researchers examined the role of metastasis-associated protein 1 (MTA1) in regulating mammary gland involution using mammary epithelial-specific MTA1 deletion.