[VivoSim Labs, Inc. ] VivoSim Labs, Inc., a provider of next-generation New Approach Methodologies (NAM) 3D human cellular models for preclinical safety and efficacy, announced that it is extending its human tissue platform beyond toxicology with efficacy testing services built on NAMkind™ disease models of the liver and intestine.

[ Acta Pharmaceuticals, Inc.] Acta Pharmaceuticals, Inc. announced $24 million in total seed financing to advance a pipeline of therapies designed for early intervention in Alzheimer’s disease. Acta’s Combination Therapies program builds on decades of research using Alzheimer’s-in-a-Dish™, laboratory models of human brain cells in mini-organoids and “assembloids”.

[Upstate Medical University] Upstate Medical University has been awarded $1.5 million by New York state to create an advanced research center for brain diseases. Upstate will establish the Biospecimen-iPSC-Organoid Node, which will integrate biospecimens, induced pluripotent stem cells and organoid models to support human-centered neuroscience research.

[Proceedings of the National Academy of Sciences of the United States of America] To overcome limitations of Earth-based models and leverage the unique advantages of space, the authors utilized a panel of glioblastoma-myeloid organoids cultured for 40 days aboard the International Space Station.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers established a human cortical organoid model to investigate CD8⁺ T cell responses to Amyloid-β-induced neurodegenerative stress.

[JHEP Reports] Investigators established a biobank of patient-derived organoids (PDOs) from tumor tissues. A protocol for organoid establishment from cryopreserved tissue was optimised in mice, confirmed in human PDO, and validated across institutions.

[ACS Sensors] Scientists present their lanthanide imaging toolkit which enables direct, quantitative, multiplex imaging of multiple protein targets in cell-line-derived organoids.

[Experimental Hematology & Oncology] The authors compared OncoPro™ and Wnt media across 36 patient-derived tumor organoid lines from various malignancies (colorectal, pancreatic, breast, lung, gastric, gastroesophageal junction, biliary head and neck and unknown primary), assessing establishment success.

[Development] Researchers investigated the transcription factor PAX6's roles in human neurodevelopment using homozygous PAX6 mutant human cerebral organoids.

[Molecular Neurobiology] Investigators used induced pluripotent stem cell-derived human hippocampal organoids at 60 days of development to investigate valproic acid-induced changes in messenger RNA and microRNA profiles.

[Scientific Reports] Scientists evaluated multiple custom-made and commercial cryopreservation containers and media on glioblastoma (GBM) self-renewal, as well as cell viability, structure, and stem cell preservation in large matrix-based GBM organoids and organoids directly from patient tissue.

[Scientific Reports] The authors compared three systems for human lung organoids - animal-derived, animal-free, and scaffold-free - under basal-out, apical-out, and proximally differentiated conditions.