Keep Current with the Latest in Cell Biology Research
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Extracellular Vesicles Powered Cancer Immunotherapy: Targeted Delivery of Adenovirus-Based Cancer Vaccine in Humanized Melanoma Model
[Journal of Controlled Release] Researchers proposed the systemic administration of the adenovirus-based cancer vaccine complexed in extracellular vesicles. The antineoplastic properties of the oncolytic vaccine were evaluated in xenograft MUG Mel-2 melanoma mice.
Scaffold-Based Tissue Engineering Strategies for Urethral Repair and Reconstruction
[Biofabrication] Tissue-engineered urethral scaffolds that combined cells or bioactive factors with a biomaterial to mimic the native microenvironment of the urethra, offering a promising approach to urethral reconstruction.
Effects of Microgravity on Human iPSC-Derived Neural Organoids on the International Space Station
[Stem Cells Translational Medicine] Researchers developed a unique organoid strategy for modeling specific regions of the brain that were affected by neurodegenerative diseases. Organoids were cultured using a sealed cryovial culture method on the International Space Station and a parallel set that remained on Earth.
First Patient Takes Part in New Phase I Clinical Trial for Patients with Recurrent Glioblastoma
[UCLH NHS Foundation Trust] Paul Read is the first patient to be recruited to a new clinical trial that has opened at University College London Hospitals NHS Foundation Trust (UCLH). Scans revealed a 50 per cent reduction in his tumor at the end of treatment.
ESSA Pharma Announces Termination of Phase II Study Evaluating Masofaniten Combined with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer
[ESSA Pharma, Inc.] ESSA Pharma, Inc. announced that it has made the decision to terminate the Phase II clinical trial evaluating masofaniten combined with enzalutamide versus enzalutamide single agent in patients with metastatic CRPC naïve to second-generation anti-androgens.
Interactions and Communications in the Prostate Tumour Microenvironment: Evolving Towards Effective Cancer Therapy
[Journal of Drug Targeting] Scientists discuss the various mechanisms by which the tumor microenvironment influences prostate cancer progression. The roles of different cells, cytokines, chemokines, and growth factors in modulating the immune response and prostate tumour growth are discussed.
Recent Advances in Basic Research on Prostate Cancer: Where We Are Heading?
[International Journal of Urology] The authors provide an overview of recent basic research in prostate cancer, focusing on two main areas: prostate cells and their tumor microenvironments.
Cell-Autonomous IL6ST Activation Suppresses Prostate Cancer Development via STAT3/ARF/p53-Driven Senescence and Confers an Immune-Active Tumor Microenvironment
[Molecular Cancer] Scientists constitutively activated interleukin-6 cytokine family signal transducer (IL6ST) signaling in the prostate epithelium of a Pten-deficient prostate cancer mouse model in vivo and examined IL6ST expression in large cohorts of prostate cancer patients.
The Emerging Role of Gut Hormones
[Molecules and Cells] Investigators discuss the role of the gut as an endocrine organ, emphasizing the stimuli, the newly discovered functions, and the clinical significance of gut-secreted hormones.
Human iPSC-Derived Neural Stem Cells Displaying Radial Glia Signature Exhibit Long-Term Safety in Mice
[Nature Communications] The authors demonstrated that hiPSC-neural stem/progenitor cells adopted a radial glia-associated signature, sharing key epigenetic and transcriptional characteristics with human fetal neural stem cells while exhibiting divergent profiles from glioblastoma stem cells.
Intracavernosal Mesenchymal Stem Cell Therapy in Ischemic Priapism: An Experimental Study
[International Urology and Nephrology] 30 male Wistar albino rats were divided into three groups: sham, priapism, and priapism + MSC treatment. The experimental groups were also divided into 1 and 12 hour subgroups of ischaemic priapism.
Characterization of RNA Editing and Gene Therapy with a Compact CRISPR-Cas13 in the Retina
[Proceedings of The National Academy of Sciences of The United States of America] Investigators reported significant transcriptomic signatures of Cas13bt3 expression in retinal cells and show all-in-one adeno-associated virus gene therapy with Cas13bt3 can effectively silence VEGFA mRNA in human retinal organoids and humanized VEGF transgenic mouse models.