[Molecular Therapy] Researchers evaluated CRISPR/Cas9 and CRISPR/Cas12a for gene knock-in at the immunoglobulin heavy chain locus in non-human primate hematopoietic stem and progenitor cells.

[Leukemia] The authors generated a transgenic mouse model, Phf6^R274XTg, expressing a patient-derived truncated Phf6 mutation specifically in hematopoietic lineages.

[Blood Cancer Discovery] By reconstructing epigenetic ontogeny in juvenile myelomonocytic leukemia (JMML), investigators identified a postnatal maturation state of JMML stem cells with high transcriptional plasticity indicative of oncofetal reprogramming in high-risk disease.

[Stem Cells] Investigators evaluated the hematopoietic effects of eltrombopag using umbilical cord blood-derived hematopoietic progenitor cells and a humanized hematopoiesis model in immunodeficient mice.

[Hematology] An immune-mediated aplastic anemia mouse model was established and treated with sovleplenib. Hematopoietic function was assessed via peripheral blood counts and bone marrow mononuclear cell counts.

[Cancer Discovery] The authors developed CRISPR-based methods to directly correct DNMT3A^R882 mutations in leukemic cells obtained from patients.

[Expert Opinion on Investigational Drugs] The authors summarize the biology, preclinical data, and emerging clinical data in the development of novel bromodomain and extra-terminal domain inhibitor.

[Shorla Oncology (Businesswire)] Shorla Oncology announced that the US FDA has approved the company’s oncology drug, Nelarabine Injection, in a larger vial size, 375mg/75mL, for adult and pediatric patients with T cell acute lymphoblastic leukemia and T cell lymphoblastic lymphoma.

[Archives of Biochemistry and Biophysics] Scientists showed the healing process of skin wounds in diabetic rats was notably delayed, but this delay was mitigated by the administration of adipose-derived MSC-derived exosomes.

[Human Cell] Researchers produced conditioned medium using primary cultures from human adipose-derived MSCs. This medium was used as treatment in a culture of keratinocyte cell line from adult human skin to investigate the modulation of their dynamics.

[Biochemistry and Biophysics Reports] The authors investigated the pro-angiogenic role and potential mechanisms of ectopic endometrial MSC-derived exosomes.

[Cell Death Discovery] The authors investigated the therapeutic potential of MSCs in managing the excess proinflammatory response and maintaining immune homeostasis in Plasmodium berghei ANKA infected C57BL/6 mice, an experimental cerebral malaria disease model.