Keep Current with the Latest in Cell Biology Research

Translational Stem Cell Therapy: Vascularized Skin Grafts in Skin Repair and Regeneration

The authors summarize the current cell therapies used in skin regeneration with a focus on the importance of vascularization and recent progress in 3D fabrication approaches to generate vascularized network in the skin tissue graft.
[Journal of Translational Medicine]
Phua, Q. H., Han, H. A., & Soh, B.-S. (2021). Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration. Journal of Translational Medicine, 19(1), 83. https://doi.org/10.1186/s12967-021-02752-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

In Vivo CRISPR Screening Reveals Nutrient Signaling Processes Underpinning CD8+ T Cell Fate Decisions

Scientists established that nutrient uptake and signaling are key determinants of T cell fate and shape the quantity and quality of memory T cell responses.
[Cell]
Huang, H., Zhou, P., Wei, J., Long, L., Shi, H., Dhungana, Y., Chapman, N. M., Fu, G., Saravia, J., Raynor, J. L., Liu, S., Palacios, G., Wang, Y.-D., Qian, C., Yu, J., & Chi, H. (2021). In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.02.021 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

METTL3-Dependent m6A Modification Programs T Follicular Helper Cell Differentiation

Researchers showed conditional deletion of METTL3 in CD4+ T cells impaired TFH differentiation and germinal center responses in a cell-intrinsic manner in mice.
[Nature Communications]
Yao, Y., Yang, Y., Guo, W., Xu, L., You, M., Zhang, Y.-C., Sun, Z., Cui, X., Yu, G., Qi, Z., Liu, J., Wang, F., Liu, J., Zhao, T., Ye, L., Yang, Y.-G., & Yu, S. (2021). METTL3-dependent m 6 A modification programs T follicular helper cell differentiation. Nature Communications, 12(1), 1333. https://doi.org/10.1038/s41467-021-21594-6 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Pre-Mitotic Genome Re-Organisation Bookends the B Cell Differentiation Process

Scientists elucidated the chromosome conformational changes in B lymphocytes as they differentiated and expanded from a naive, quiescent state into antibody secreting plasma cells.
[Nature Communications]
Chan, W. F., Coughlan, H. D., Zhou, J. H. S., Keenan, C. R., Bediaga, N. G., Hodgkin, P. D., Smyth, G. K., Johanson, T. M., & Allan, R. S. (2021). Pre-mitotic genome re-organisation bookends the B cell differentiation process. Nature Communications, 12(1), 1344. https://doi.org/10.1038/s41467-021-21536-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Multimodal Pooled Perturb-Cite-Seq Screens in Patient Models Define Mechanisms of Cancer Immune Evasion

In patient-derived melanoma cells and autologous tumor-infiltrating lymphocyte co-cultures, scientists profiled transcriptomes and 20 proteins in ~218,000 cells under ~750 perturbations associated with cancer cell-intrinsic immune checkpoint inhibitor resistance
[Nature Genetics]
Frangieh, C. J., Melms, J. C., Thakore, P. I., Geiger-Schuller, K. R., Ho, P., Luoma, A. M., Cleary, B., Jerby-Arnon, L., Malu, S., Cuoco, M. S., Zhao, M., Ager, C. R., Rogava, M., Hovey, L., Rotem, A., Bernatchez, C., Wucherpfennig, K. W., Johnson, B. E., Rozenblatt-Rosen, O., … Izar, B. (2021). Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion. Nature Genetics, 1–10. https://doi.org/10.1038/s41588-021-00779-1 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Affinity-Matured Hla Class II Dimers for Robust Staining of Antigen-Specific CD4+ T Cells

Researchers produced affinity-matured class II dimers that stain antigen-specific T cells better than conventional multimers in both in vitro and ex vivo analyses.
[Nature Biotechnology]
Sugata, K., Matsunaga, Y., Yamashita, Y., Nakatsugawa, M., Guo, T., Halabelian, L., Ohashi, Y., Saso, K., Rahman, M. A., Anczurowski, M., Wang, C.-H., Murata, K., Saijo, H., Kagoya, Y., Ly, D., Burt, B. D., Butler, M. O., Mak, T. W., & Hirano, N. (2021). Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4 + T cells. Nature Biotechnology, 1–10. https://doi.org/10.1038/s41587-021-00836-4 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Cholesterol Loading Suppresses the Atheroinflammatory Gene Polarization of Human Macrophages Induced by Colony Stimulating Factors

Scientists generated human macrophages in the presence of either macrophage-colony stimulating factor or granulocyte–macrophage-colony stimulating factor to obtain M-MØ and GM-MØ.
[Scientific Reports]
Lappalainen, J., Yeung, N., Nguyen, S. D., Jauhiainen, M., Kovanen, P. T., & Lee-Rueckert, M. (2021). Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors. Scientific Reports, 11(1), 4923. https://doi.org/10.1038/s41598-021-84249-y Cite
Full Article
Bookmark

No account yet? Register

0
Share

SARS-CoV-2 Engages Inflammasome and Pyroptosis in Human Primary Monocytes

Scientists showed that SARS-CoV-2 engaged inflammasome and triggered pyroptosis in human monocytes, experimentally infected, and from patients under intensive care.
[Cell Death Discovery]
Ferreira, A. C., Soares, V. C., de Azevedo-Quintanilha, I. G., Dias, S. da S. G., Fintelman-Rodrigues, N., Sacramento, C. Q., Mattos, M., de Freitas, C. S., Temerozo, J. R., Teixeira, L., Damaceno Hottz, E., Barreto, E. A., Pão, C. R. R., Palhinha, L., Miranda, M., Bou-Habib, D. C., Bozza, F. A., Bozza, P. T., & Souza, T. M. L. (2021). SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-021-00428-w Cite
Full Article
Bookmark

No account yet? Register

0
Share

Effector and Stem-Like Memory Cell Fates Are Imprinted in Distinct Lymph Node Niches Directed by CXCR3 Ligands

Scientists developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate.
[Nature Immunology]
Duckworth, B. C., Lafouresse, F., Wimmer, V. C., Broomfield, B. J., Dalit, L., Alexandre, Y. O., Sheikh, A. A., Qin, R. Z., Alvarado, C., Mielke, L. A., Pellegrini, M., Mueller, S. N., Boudier, T., Rogers, K. L., & Groom, J. R. (2021). Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands. Nature Immunology, 1–15. https://doi.org/10.1038/s41590-021-00878-5 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Immunomodulating Nano-Adaptors Potentiate Antibody-Based Cancer Immunotherapy

Investigators built up a versatile antibody immobilization platform by conjugating anti-IgG antibody onto the nanoparticle surface.
[Nature Communications]
Jiang, C.-T., Chen, K.-G., Liu, A., Huang, H., Fan, Y.-N., Zhao, D.-K., Ye, Q.-N., Zhang, H.-B., Xu, C.-F., Shen, S., Xiong, M.-H., Du, J.-Z., Yang, X.-Z., & Wang, J. (2021). Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy. Nature Communications, 12(1), 1359. https://doi.org/10.1038/s41467-021-21497-6 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Single-Cell Analyses Reveal the Clonal and Molecular Aetiology of Flt3L-Induced Emergency Dendritic Cell Development

Researchers examined the aetiology of the Flt3 ligand (Flt3L)-mediated increase of type 1 conventional dendritic cells.
[Nature Cell Biology]
Lin, D. S., Tian, L., Tomei, S., Amann-Zalcenstein, D., Baldwin, T. M., Weber, T. S., Schreuder, J., Stonehouse, O. J., Rautela, J., Huntington, N. D., Taoudi, S., Ritchie, M. E., Hodgkin, P. D., Ng, A. P., Nutt, S. L., & Naik, S. H. (2021). Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development. Nature Cell Biology, 1–13. https://doi.org/10.1038/s41556-021-00636-7 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share