Keep Current with the Latest in Cell Biology Research

Distinct Cellular Dynamics Associated with Response to CAR-T Therapy for Refractory B Cell Lymphoma

[Nature Medicine] Researchers performed single-cell transcriptome sequencing of 105 pretreatment and post-treatment peripheral blood mononuclear cell samples, and infusion products collected from 32 individuals with large B cell lymphoma treated with CD19 CAR-T products.

Chimeric Antigen Receptor T Cell Therapy for Relapsed and Refractory Thyroid Cancer

[Experimental Hematology & Oncology] Scientists showed a relapsed and refractory thyroid cancer patient treated with thyroid-stimulating hormone receptor + (TSHR) CD19 CAR-T, a combination of two 2nd generation CAR-T molecules targeting both TSHR and CD19.

Genetically Modified CD7-Targeting Allogeneic CAR T Cell Therapy with Enhanced Efficacy for Relapsed/Refractory CD7-Positive Hematological Malignancies: A Phase I Clinical Study

[Cell Research] Scientists developed healthy donor-derived, CD7-targeting CAR-T cells with genetic modifications to resist fratricide, graft-versus-host disease and allogeneic rejection, as well as to potentiate antitumor function.

Single-Cell Spatiotemporal Analysis Reveals Cell Fates and Functions of Transplanted Mesenchymal Stromal Cells during Bone Repair

[Stem Cell Reports] The authors developed a single-cell 3D spatial correlation (sc3DSC) method to track transplanted MSCs based on deep tissue microscopy of fluorescent nanoparticles (fNPs) and immunofluorescence of key proteins.

Allogeneic Hematopoietic Cell Transplantation Can Overcome the Adverse Prognosis Indicated by Secondary-Type Mutations in De Novo Acute Myeloid Leukemia

[Bone Marrow Transplantation] In 394 patients diagnosed with de novo acute myeloid leukemia who had a normal karyotype, the genetic profiling via targeted deep sequencing of 45 genes revealed 59 patients carrying secondary-type mutations.

CBFA2T3-GLIS2 Model of Pediatric Acute Megakaryoblastic Leukemia Identifies FOLR1 as a CAR T Cell Target

[Journal of Clinical Investigation] Researchers developed CAR T cells directed against one of the targets, FOLR1, and demonstrated their pre-clinical efficacy against CBFA2T3-GLIS2 acute megakaryoblastic leukemia using in vitro and xenograft models.

Tanshinone IIA-Loaded Nanoparticle and Neural Stem Cell Therapy Enhances Recovery in a Pig Ischemic Stroke Mode

[Stem Cells Translational Medicine] Researchers evaluated the potential of Tan IIA drug-loaded nanoparticles to improve iPSC-derived neural stem cells engraftment and efficacy, thus potentially leading to enhanced cellular, tissue, and functional recovery in a translational pig ischemic stroke model.

Therapeutic Targets and Biomarkers of Tumor Immunotherapy: Response versus Non-Response

[Signal Transduction and Targeted Therapy] The authors describe the efforts to manipulate the immune system against cancer and discuss different targets and cell types that can be exploited to promote the antitumor immune response.

Towards Precision Oncology with Patient-Derived Xenografts

[Nature Reviews Clinical Oncology] Investigators discuss examples from the past decade of the use of patient-derived xenograft models for precision oncology, from translational research to drug discovery.

Neurona Therapeutics Presents Clinical Case Study from First Human Trial of Regenerative Cell Therapy, NRTX-1001, in Adults with Drug-Resistant Focal Epilepsy

[Neurona Therapeutics] Neurona Therapeutics announced the presentation of a clinical case study from the initial dose cohort of the Phase I/II first-in-human epilepsy clinical trial of its lead program, NRTX-1001.

Artiva Biotherapeutics Announces FDA Allowance of IND for AB-201, a HER2-Targeted CAR-NK for the Treatment of Solid Tumors

[Artiva Biotherapeutics, Inc.] Artiva Biotherapeutics, Inc. announced that the US FDA has cleared the company’s investigational new drug (IND) application for AB-201. AB-201 is an allogeneic HER2-targeted CAR NK cell therapy for the treatment of solid tumors in the outpatient setting with the option for repeat dosing.

Snail Maintains the Stem/Progenitor State of Skin Epithelial Cells and Carcinomas through the Autocrine Effect of Matricellular Protein Mindin

[Cell Reports] In models of cutaneous squamous cell carcinoma, investigators discovered a non-epithelial-mesenchymal transition function for the transcription factor Snail in maintaining the stemness of epidermal keratinocytes.

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