Keep Current with the Latest in Cell Biology Research
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Glioblastoma-Instructed Astrocytes Suppress Tumor-Specific T Cell Immunity
[Nature] The authors used single-cell and bulk RNA sequencing of clinical glioblastoma samples and samples from preclinical models, multiplexed immunofluorescence, in vivo CRISPR-based cell-specific genetic perturbations and in vitro mouse and human experimental systems to study the role of astrocytes in the immune response to glioblastoma.
Mutations in NEK1 Cause Ciliary Dysfunction As a Novel Pathogenic Mechanism in Amyotrophic Lateral Sclerosis
[Molecular Neurodegeneration] The authors studied the genetic contribution of NIMA-related kinase 1 (NEK1) to ALS pathogenesis by analyzing the exome sequences of 920 Korean patients with ALS.
A Postsynaptic GPR158-PLCXD2 Complex Controls Spine Apparatus Abundance and Dendritic Spine Maturation
[Developmental Cell] Researchers identified a postsynaptic signaling complex comprising the G protein-coupled receptor- GPR158 and a constitutively active phospholipase C (PLC) family member, PLC X-domain containing 2 (PLCXD2), that controls spine apparatus abundance.
Stathmin-2 Enhances Motor Axon Regeneration after Injury Independent of Its Binding to Tubulin
[Proceedings of The National Academy of Sciences of The United States of America] Scientists determined that stathmin-2 is required for functional recovery and reinnervation of neuromuscular junctions after sciatic nerve crush injury.
Physical Activity Stimulates Clock Neurons of the Day-Active Rodent Arvicanthis ansorgei
[Proceedings of The National Academy of Sciences of The United States of America] By recording from clock neurons, investigators established that physical activity leads to immediate activation of the neurons in the diurnal rodent, Arvicanthis.
Exploring the Complexity of MECP2 Function in Rett Syndrome
[Nature Reviews Neuroscience] Scientists review recent insights from epigenomic, transcriptomic, and proteomic studies that advance the understanding of MECP2 as an interacting hub for DNA, RNA, and transcription factors, orchestrating diverse processes that are crucial for neuronal function.
Filamin A in Focus: Unravelling the Multifaceted Roles of Filamin A in Neurodevelopment and Neurological Disorder
[Brain] The authors delve into filamin A’s multifaceted role in neurodevelopment, with a particular focus on its contributions to neuronal migration, dendritic and axonal growth, and mechanotransduction.
Brain Canada Invests in Six Montreal-Area Platforms to Drive Open Science Innovation
[Brain Canada] Six exceptional research platforms located in Montreal have been awarded funding through Brain Canada's Platform Support Grants program.
Small Molecule and Cell Contact-Inducible Systems for Controlling Expression and Differentiation in Mouse Embryonic Stem Cells
[Development] Scientists characterized three small molecule and two cell contact-inducible systems for gene expression in and differentiation of mESCs.
Oxyresveratrol Enhances Hair Regeneration in Human Dermal Papilla Cell and Androgenetic Alopecia Mouse Model
[Scientific Reports] Researchers evaluated the effects of oxyresveratrol on human follicle dermal papilla cells and an androgenetic alopecia mouse model.
Mesenchymal Stromal Cells for Steroid-Refractory Biopsy-Proven Grade III-IV Acute Graft-Versus-Host Disease with Predominant Gastrointestinal Involvement
[Frontiers in Immunology] This prospective, observational, single-arm, single-center study assessed the efficacy and safety of bone marrow-derived MSCs for treating adult patients with biopsy-proven grade III-IV steroid-refractory acute graft-versus-host disease with predominant GI involvement.
TATA-Box Binding Protein Associated Factor 2 (TAF2) in Hepatocyte Survival and Tumorigenesis
[Hepatology] The authors explored the role of TATA-box binding protein associated factor 2 (TAF2) in HCC regulation using a hepatocyte-specific conditional knockout mouse, TAF2 knockdown and overexpressing human HCC cells, and TAF2 overexpression in mouse liver by hydrodynamic approach.