[Oncogene] Gain and loss of function studies demonstrated that chromobox homolog 2 (CBX2) significantly promoted colorectal cancer (CRC) progression and chemoresistance in cell lines, patient-derived CRC organoids and xenografts.

[American Journal of Hematology] The authors provide a contemporary review on HSC transplantation for myelodysplastic neoplasms and myelofibrosis, highlighting up-to-date insights into disease biology, standard of care, and recommendations, as well as open avenues.

[Stem Cell Reports] Investigators showed that naive PSCs from inbred mouse strains exhibited strain-specific susceptibility to locus-specific deregulation of imprinting marks during reprogramming and upon exposure to a mitogen-activated protein kinase inhibitor, a common approach to maintain naive pluripotency.

[Journal of Cell Science] Scientists investigated how the actin cytoskeleton was regulated in different pluripotency states. They observed a drastic reorganization during the transition from ground-state naïve mESCs into converted prime epiblast stem cells.

[Science Advances] Scientists hypothesized that the lysine demethylase ubiquitously transcribed tetratricopeptide repeat containing Y-linked (UTY) decreased methylation uniquely in male valvular interstitial cells responding to nanoscale ECM cues to promote an osteoblast-like cell phenotype.

[ACS Nano] Investigators demonstrated that chemical modification of MSCs with anti-VCAM1 and polydopamine significantly enhanced MSC survival and promoted cardiac repair.

[Scientific Reports] Researchers discovered that melatonin inhibited cancer cell proliferation, migration, and invasion, as well as reduced PD-L1 expression in cancer cells.

[Cancer Discovery] Scientists reported that an epigenetically altered MSC niche, termed high risk MSC, existed prior to serous tubal intraepithelial carcinoma lesion formation.

[Leukemia] Scientists found that the kdm4b−/− mutant zebrafish developed an ineffective erythropoiesis-like defect, including impaired terminal maturation and apoptosis of erythroblasts, as confirmed by observations in Kdm4b−/− mutant mice.

[Clinical Cancer Research] Investigators assessed the benefit of adjuvant aspirin in resected PIK3CA-mutated colon cancer patients. Patients with resected colon cancer stage II and III harbouring an activating PIK3CA mutation were included.

[Leukemia] This retrospective study of essential thrombocythemia and polycythemia vera patients diagnosed before age 25 evaluated complication rates and impact of cytoreductive drugs on outcomes.

[Journal For Immunotherapy of Cancer] This Phase II study evaluated the efficacy and safety of combining neoadjuvant durvalumab with docetaxel, oxaliplatin, and S-1, followed by surgery and adjuvant durvalumab plus S-1 chemotherapy, for resectable locally advanced gastric cancer.