[Development] Investigators showed that the mouse fetal liver and fetal circulation contained a transient population of Pax3 lineage cells with hallmarks of hematopoietic progenitors and the potential to generate both myeloid and erythroid cells.

[Circulation Research] Tamoxifen-inducible Cre genetic mouse models were used to permit either transcription factor 21 (Tcf21) gene deletion or its enforced expression in adult cardiac fibroblasts. Histological analyses were used, as well as transcriptomic analysis to determine the consequences of TCF21 gain-of-function and loss-of-function in vivo.

[Circulation Research] Researchers explored whether a vaccine targeting fibroblast activation protein could eliminate myofibroblasts in chronic cardiac stress model mice and reduce cardiac fibrosis.

[Nature] Scientists discovered that fructose supplementation enhanced tumour growth in animal models of melanoma, breast cancer, and cervical cancer without causing weight gain or insulin resistance.

[Nature] Researchers used single-cell profiling on patient biopsies across the disease continuum and found that a distinct population of tumour-associated macrophages with elevated levels of SPP1 transcripts became enriched with the progression of prostate cancer to metastatic CRPC.

Using a preclinical model of chronic experimental asthma, investigators demonstrated that rhinovirus-induced exacerbations increased prostaglandin D2 release, mucus production, transforming growth factor-β1 and type-2...

[Experimental Lung Research] Scientists hypothesized that ErbB4 deletion affected the ultrastructure of alveolar epithelial type II cells, specifically lamellar bodies and the intracellular distribution of the immunomodulating hydrophilic surfactant proteins (SP)-A and the hydrophobic SP-B.

[International Journal of Cancer] Researchers performed preclinical studies on the combination of pirfenidone with vinorelbine, or with vinorelbine plus carboplatin, in NSCLC.

[Current Treatment Options In Oncology] Scientists explore the efficacy and safety of combining radiotherapy with immunotherapy in the treatment of stage IV NSCLC, delving into the intricacies of their underlying mechanism.

[Merus, N.V.] Merus, N.V. announced that the US FDA approved BIZENGRI®, a treatment indicated for adults with pancreatic adenocarcinoma or NSCLC that are advanced unresectable or metastatic and harbor a neuregulin 1 (NRG1) gene fusion who have disease progression on or after prior systemic therapy.

[PeerJ] To bridge the gaps between basic research and pharmaceutical as well as clinical applications, efforts have been made to develop organoids from tissue-derived stem cells or pluripotent stem cells. The authors summarize the status of organoid development and applications and highlight recent progress and limitations.

[Current HIV/Aids Reports] The authors review the role of innate immune cells in shaping the viral reservoir and maintenance of long-term viral control of spontaneous Elite and Viremic HIV controllers.