[British Journal of Cancer] The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.

[British Journal of Cancer] 582 mCRPC patients undergoing first-line abiraterone therapy from four institutions were sorted by three phases: discovery, training, and validation.

[International Journal of Radiation Oncology*Biology*Physics] Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.

[Journal of Cell Communication and Signaling] Scientists investigated the regulatory effects of estrogens on endoplasmic reticulum (ER)-associated degradation (ERAD) and unfolded protein response (UPR) and their impacts on prostate carcinogenesis.

[Gerontology] To explore the molecular mechanism of intra-vesical prostatic protrusion (IPP) formation, investigators performed RNA sequencing on prostate tissue stromal cells obtained from IPP-derived primary cultures.

[Frontiers in Genetics] Researchers identified prostate cancer (PCa) subtypes and constructed a gene signature that could predict the recurrence-free survival of PCa patients based on chromatin regulators genes.

[Toxicology and Applied Pharmacology] The authors demonstrated that three out of four tested prostate cancer cell lines pretreated with mycotoxin deoxynivalenol increased tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-induced apoptosis detected with flow cytometry.

[Investigational New Drugs] Viscosalactone B was first identified as a novel lysine-specific demethylase 1 (LSD1) inhibitor. Viscosalactone B isolated from Withania Somnifera displayed antiproliferative activity against PC3, DU145, C42B, PC3/MDVR, DU145/MDVR, and C42B/MDVR cells.

[PATHOLOGY RESEARCH AND PRACTICE] Scientists investigated the role and molecular mechanism of glioblastoma downregulated RNA (GLIDR) in prostate cancer (PCa) cells. The results showed that GLIDR expression levels were higher in PCa samples and cells than in control.

[Future Oncology] The authors describe the current evidence regarding the accuracy and efficacy of miRNAs as biomarkers for prostate cancer.

[Expert Review of Anticancer Therapy] Investigators analyze the current imaging and treatment options for neuroendocrine Prostate Cancer, and to highlight future potential treatment strategies.

[Asian Journal of Andrology] Scientists review the roles of noncanonical wingless-type MMTV integration site family (WNT) signaling pathways, chromatin remodelers, and epigenetic enzymes in the development and progression of prostate cancer.