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Modified abundance of JPH2 and redistribution of L-type calcium channels were studied in left ventricular hypertrophy in vivo and in cultured adult feline and rat ventricular myocytes.
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Gross Polina, Johnson Jaslyn, Romero Carlos M, Eaton Deborah M, Poulet Claire, Sanchez-Alonso Jose L, Lucarelli Carla, Ross Jean, Gibb Andrew A, Garbincius Joanne F, Lambert Jonathan, Varol Erdem, Yang Yijun, Wallner Markus, Feldsott Eric A, Kubo Hajime, Berretta Remus M, Yu Daohai, Rizzo Victor, … Houser Steven R. (n.d.). Interaction of the Joining Region in Junctophilin-2 with the L-type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.315715 Cite
In rat and mouse models of ischemic heart failure, investigators showed that miR-30d gain of function improves cardiac function, decreases myocardial fibrosis, and attenuates cardiomyocyte apoptosis.
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Li Jin, Salvador Ane M, Li Guoping, Valkov Nedyalka, Ziegler Olivia, Yeri Ashish Suresh, Xiao Chun Yang, Meechoovet Bessie, Alsop Eric, Rodosthenous Rodosthenis S, Kundu Piyusha, Huan TianXiao, Levy Daniel, Tigges John C, Pico Alexander R, Ghiran Ionita, Silverman Michael G, Meng Xiangmin, Kitchen Robert, … Das Saumya. (n.d.). Mir-30d Regulates Cardiac Remodeling by Intracellular And Paracrine Signaling. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317244 Cite
The authors showed that cardiomyocyte-specific deletion of Brd4 in adult mice leads to acute deterioration of cardiac contractile function with mutant animals demonstrating a transcriptomic signature enriched for decreased expression of genes critical for mitochondrial energy production.
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Padmanabhan Arun, Alexanian Michael, Linares-Saldana Ricardo, González-Terán Bárbara, Andreoletti Gaia, Huang Yu, Connolly Andrew J., Kim Wonho, Hsu Austin, Duan Qiming, Winchester Sarah A. B., Felix Franco, Perez-Bermejo Juan A., Wang Qiaohong, Li Li, Shah Parisha P., Haldar Saptarsi M., Jain Rajan, & Srivastava Deepak. (n.d.). BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.047753 Cite
The authors investigated the pathophysiological phenotypes and mechanisms using induced pluripotent stem cell-derived cardiomyocytes from two Brugada syndrome patients carrying a heterozygous SCN5A mutation p.S1812X.
[Frontiers in Cell and Developmental Biology]
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Li, W., Stauske, M., Luo, X., Wagner, S., Vollrath, M., Mehnert, C. S., Schubert, M., Cyganek, L., Chen, S., Hasheminasab, S.-M., Wulf, G., El-Armouche, A., Maier, L. S., Hasenfuss, G., & Guan, K. (2020). Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.592893 Cite
Researchers compared effects of plasma-activated medium with effects of conventional clinical thermal therapy on both lung cancer cells and benign cells for management of malignant pleural effusion.
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In 290 normal subjects from the GeneSTAR Research Study, investigators generated whole genome sequence data from whole blood and RNA sequence data from extracted non-ribosomal RNA from 185 induced pluripotent stem cell-derived megakaryocyte cell lines and 290 blood platelet samples from these subjects.
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Kammers, K., Taub, M., Rodriguez, B., Yanek, L. R., Ruczinski, I., Martin, J., Kanchan, K., Battle, A., Cheng, L., Wang, Z. Z., Johnson, A. D., Leek, J., Faraday, N., Becker, L., & Mathias, R. (n.d.). Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole genome and RNA sequencing. Blood. https://doi.org/10.1182/blood.2020006115 Cite
Researchers indicate p53 as a critical mediator of 5-Fluorouracil (5-FU)-induced cancer stem cell activation via the WNT/β-catenin signaling pathway and highlight the significance of combinatorial treatment of WNT inhibitor and 5-FU as a compelling therapeutic strategy to improve the poor outcomes of current 5-FU-based therapies for colorectal cancer patients.
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5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation | Nature Communications. (n.d.). Retrieved October 23, 2020, from https://www.nature.com/articles/s41467-020-19173-2 Cite
To what extent stromal cells in the tumor microenvironment are transformed by colorectal cancer (CRC) cells is unexplored.To dissect alterations in these non-malignant cells, researchers performed single-cell multiomics sequencing of 21 patients with microsatellite-stable colorectal cancers and 6 cancer-free, elderly individuals.
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Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer: Cancer Cell. (n.d.). Retrieved October 23, 2020, from https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30489-X?rss=yes&utm_source=dlvr.it&utm_medium=twitter Cite
NeuClone Pharmaceuticals Ltd announced its biosimilar candidate of Stelara®, NeuLara, has successfully met all primary and secondary endpoints in a Phase I clinical trial. NeuLara is being developed as a biosimilar of ustekinumab, an antibody targeting interleukin-12 and -23, approved under the brand name Stelara® to treat patients with plaque psoriasis, psoriatic arthritis, Crohn’s disease and ulcerative colitis.
[NeuClone Pharmaceuticals Ltd.]
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Scientists found that cyclic dinucleotides(CDNs) containing adenosine induced a robust CFTR-mediated chloride secretory response together with cAMP-mediated inhibition of Poly I:C-stimulated IFNβ expression. Signal transduction was strictly polarized to the serosal side of the epithelium, dependent on the extracellular and sequential hydrolysis of CDNs to adenosine by the ectonucleosidases ENPP1 and CD73, and occurred via activation of A2B adenosine receptors.
[Proceedings of the National Academy of Sciences of the United States of America]
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Chang, D., Whiteley, A. T., Gwilt, K. B., Lencer, W. I., Mekalanos, J. J., & Thiagarajah, J. R. (2020). Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2015919117 Cite
Scientists used a well-established mouse model of sporadic colorectal cancer induced by azoxymethane to determine the possible role of fragile X mental retardation protein in colorectal cancer.
[Cellular and Molecular Gastroenterology and Hepatology]
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Di Grazia, A., Marafini, I., Pedini, G., Di Fusco, D., Laudisi, F., Dinallo, V., Rosina, E., Stolfi, C., Franzè, E., Sileri, P., Sica, G., Monteleone, G., Bagni, C., & Monteleone, I. (2020). The Fragile X Mental Retardation Protein regulates RIP1K and colorectal cancer resistance to necroptosis. Cellular and Molecular Gastroenterology and Hepatology. https://doi.org/10.1016/j.jcmgh.2020.10.009 Cite