Investigators used a combination of in vivo postpartum breast cancer models and in vitro assays to study the effects of inactivation of the MNK1/2-eIF4E axis on the pro-tumor function of select cells of the TME
[Cancer Research]
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Keep Current with the Latest in Cell Biology Research
Visualizing Extracellular Vesicles and Their Function in 3D Tumor Microenvironment Models
The authors discuss extracellular vesicle (EV) biology in 3D culture correlates of the tumor microenvironment (TME). This includes EV communication between cell types of the TME, differences in EV biogenesis and signaling associated with differing scaffold choices and in scaffold-free 3D cultures and cultivation of the premetastatic niche.
[International Journal of Molecular Sciences]
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CSA Medical Announces Completion of Enrollment in Mechanism of Action Study Utilizing the RejuvenAir® System for COPD Patients with Chronic Bronchitis
CSA Medical, Inc. announced that all subjects have been enrolled in the RejuvenAir® System study. The aim of this study is to determine the mechanism by which Metered CryoSpray reduces the density of goblet cells responsible for over-producing mucus and observe re-growth of healthy cilia in the airways.
[CSA Medical, Inc. (Cision US, Inc.)]
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Mesenchymal Stromal Cells Reduce Evidence of Lung Injury in Patients with ARDS
Scientists carried out a nested cohort study within a Phase IIa safety trial of treatment with allogeneic MSCs for moderate to severe ARDS.
[JCI Insight]
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Mesenchymal Stromal Exosome–Functionalized Scaffolds Induce Innate and Adaptive Immunomodulatory Responses toward Tissue Repair
Biofunctional scaffolds were prepared by immobilizing mesenchymal stromal exosomes onto fibrous polyester materials and allowed cell-mediated delivery of membrane-bound vesicles.
[Science Advances]
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Cross-Tissue Organization of the Fibroblast Lineage
Targeting Epigenetic and Post-Transcriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth
Investigators conducted an in vitro chemical array screen and identified multiple small molecules that interacted with PSF. Several molecules inhibited RNA binding by PSF and decreased prostate cancer cell viability.
[Cancer Research]
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Functional Mapping of Androgen Receptor Enhancer Activity
To characterize the regulatory logic of androgen receptor (AR)-mediated transcription, researchers generated a locus-specific map of enhancer activity by functionally testing all common clinical AR binding sites with Self-Transcribing Active Regulatory Regions sequencing.
[Genome Biology]
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Hyaluronan Synthase 2 (HAS2) Regulates Cell Phenotype and Invadopodia Formation in Luminal-Like Breast Cancer Cells
Researchers showed that the level of hyaluronic acid synthase 2 (HAS2) was positively correlated with the malignant phenotype of breast cancer cells. The increased expression of HAS2 promoted the invasive and migratory abilities of luminal breast cancer cells in vitro, followed by a reduced expression of E-cadherin, β-catenin, and ZO-1, and an elevated expression of N-cadherin and vimentin.
[Molecular and Cellular Biochemistry]
Sheng, Y., Cao, M., Liu, Y., He, Y., Zhang, G., Du, Y., Gao, F., & Yang, C. (2021). Hyaluronan synthase 2 (HAS2) regulates cell phenotype and invadopodia formation in luminal-like breast cancer cells. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-021-04165-7 Cite
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MDM2 Induces EMT via the B-Raf Signaling Pathway through 14-3-3
Scientists demonstrated that the expression levels of MDM2 proto‑oncogene, E3 ubiquitin protein ligase were markedly increased in TGF‑β‑induced epithelial‑to‑mesenchymal transition using quantitative PCR and western blotting.
[Oncology Reports]
Ou, M., Xu, X., Chen, Y., Li, L., Zhang, L., Liao, Y., Sun, W., Quach, C., Feng, J., & Tang, L. (2021). MDM2 induces EMT via the B‑Raf signaling pathway through 14‑3‑3. Oncology Reports, 46(1), 1–19. https://doi.org/10.3892/or.2021.8071 Cite
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miR-4709-3p Inhibits Cell Proliferation by Downregulating TSP50 Expression in Breast Cancer Cells
The authors investigated the regulation of Serine protease 50 (TSP50) expression in breast cancer by predicting and analyzing miRNAs that could target TSP50 mRNA 3′UTR.
[DNA and Cell Biology]
Wang, Y., Xu, S., Wang, S., Song, Z., Zheng, L., Wang, G., Sun, Y., & Bao, Y. (2021). miR-4709-3p Inhibits Cell Proliferation by Downregulating TSP50 Expression in Breast Cancer Cells. DNA and Cell Biology. https://doi.org/10.1089/dna.2020.6260 Cite
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