[National Multiple Sclerosis Society] Breakthrough Type 1 Diabetes, the Lupus Research Alliance, and the National Multiple Sclerosis Society are jointly seeking applications from investigators across autoimmune and other relevant fields to advance the understanding of autoimmunity with the Common Mechanisms in Autoimmunity Insight Awards.

[Progentos Therapeutics] Progentos Therapeutics announced that the first participant has been dosed in its Phase I/IIa clinical trial of PRO-1562 (NCT07826689), a novel oral small molecule designed to regenerate myelin in patients with demyelinating diseases, like multiple sclerosis.

[National Multiple Sclerosis Society] The National Multiple Sclerosis (MS) Society announced the opening of a request for applications, a targeted funding opportunity to support development and validation of scalable, clinically practical, and implementable MS screening technologies.

[Signal Transduction and Targeted Therapy] The authors integrated single-cell profiles from peripheral blood and kidney graft samples from patients with chronic antibody-mediated rejection, bulk transcriptomic datasets, spectral flow cytometry, multiplex immunofluorescence, high-resolution spatial transcriptomics, and a large blood immune reference spanning autoimmune and inflammatory diseases.

[Gut] Investigators explored whether tissue-Tregs populate the exocrine pancreas and assessed their function in pancreatic diseases.

[Nature Cancer] Scientitst found that basophils suppress early lung metastatic seeding in mice by enhancing antitumor CD8+ T cell immunity through inhibition of Treg cells.

[The Journal of Clinical Investigation] Researchers determined that a novel class of donor-derived CD8+CD44+CD122+ Tregs plays a crucial role in controlling autoimmunity in non-obese diabetic mice with induced mixed chimerism.

[Autophagy] The authors revealed how mitochondrial oxidative stress activates protective mitophagy in autoimmune thyroiditis.

[Cancer Research] To identify the critical immunologic features associated with tumor control and escape, scientists built a mechanistic, structurally identifiable mathematical model of the interactions between CD8+ T cells, Tregs, dendritic cells, and tumor cells deeply rooted in current biological concepts.

[Proceedings of The National Academy of Sciences of The United States of America] Researchers identified Specificity Protein 1-dependent mechanosensing as a previously unrecognized pathway controlling human monocyte activation in the skin and provided mechanistic insight into how tissue stiffness sustains inflammation in systemic sclerosis.

[Proceedings of the National Academy of Sciences of the United States of America] The authors characterized a CD8⁺ Treg subset restricted by HLA-E in hemorrhagic fever with renal syndrome patients and in a murine model.

[Immunology] Investigators evaluated the therapeutic potential of the DNA methyltransferase inhibitor decitabine to mitigate immune pathology and skeletal deterioration in Foxp3-deficient scurfy mice.