Keep Current with the Latest in Cell Biology Research
[British Journal of Cancer] The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.
Plasma Extracellular Vesicle circRNA Signature and Resistance to Abiraterone in Metastatic Castration-Resistant Prostate Cancer
[British Journal of Cancer] 582 mCRPC patients undergoing first-line abiraterone therapy from four institutions were sorted by three phases: discovery, training, and validation.
[International Journal of Radiation Oncology*Biology*Physics] Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.
Estrogens Drive the Endoplasmic Reticulum-Associated Degradation and Promote Proto-Oncogene c-Myc Expression in Prostate Cancer Cells by Androgen Receptor/Estrogen Receptor Signaling
[Journal of Cell Communication and Signaling] Scientists investigated the regulatory effects of estrogens on endoplasmic reticulum (ER)-associated degradation (ERAD) and unfolded protein response (UPR) and their impacts on prostate carcinogenesis.
Up-Regulation of FGF7 Induced Intra-Vesical Prostatic Protrusion of Benign Prostatic Hyperplasia via the ERK1/2 Signaling Pathway
[Gerontology] To explore the molecular mechanism of intra-vesical prostatic protrusion (IPP) formation, investigators performed RNA sequencing on prostate tissue stromal cells obtained from IPP-derived primary cultures.
Identification of Molecular Subtypes and a Prognostic Signature Based on Chromatin Regulators Related Genes in Prostate Cancer
[Frontiers in Genetics] Researchers identified prostate cancer (PCa) subtypes and constructed a gene signature that could predict the recurrence-free survival of PCa patients based on chromatin regulators genes.
[Toxicology and Applied Pharmacology] The authors demonstrated that three out of four tested prostate cancer cell lines pretreated with mycotoxin deoxynivalenol increased tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-induced apoptosis detected with flow cytometry.
Viscosalactone B, a Natural LSD1 Inhibitor, Inhibits Proliferation In Vitro and In Vivo against Prostate Cancer Cells
[Investigational New Drugs] Viscosalactone B was first identified as a novel lysine-specific demethylase 1 (LSD1) inhibitor. Viscosalactone B isolated from Withania Somnifera displayed antiproliferative activity against PC3, DU145, C42B, PC3/MDVR, DU145/MDVR, and C42B/MDVR cells.
[PATHOLOGY RESEARCH AND PRACTICE] Scientists investigated the role and molecular mechanism of glioblastoma downregulated RNA (GLIDR) in prostate cancer (PCa) cells. The results showed that GLIDR expression levels were higher in PCa samples and cells than in control.
The Role of miRNA in Prostate Cancer Diagnosis, Prognosis, and Treatment Response: A Narrative Review
[Future Oncology] The authors describe the current evidence regarding the accuracy and efficacy of miRNAs as biomarkers for prostate cancer.
[Expert Review of Anticancer Therapy] Investigators analyze the current imaging and treatment options for neuroendocrine Prostate Cancer, and to highlight future potential treatment strategies.
Recent Advances in Prostate Cancer: WNT Signaling, Chromatin Regulation, and Transcriptional Coregulators
[Asian Journal of Andrology] Scientists review the roles of noncanonical wingless-type MMTV integration site family (WNT) signaling pathways, chromatin remodelers, and epigenetic enzymes in the development and progression of prostate cancer.