[Prostate Cancer Foundation] The Prostate Cancer Foundation announced four inaugural Class of 2022 TACTICAL Award recipients. This $30 million program will support cross-disciplinary pioneering research toward the goal of developing 21st Century therapies for the most life-threatening form of prostate cancer.

[Molecular Cell] Scientists reported that PALI1 was upregulated in advanced prostate cancer and competed with JARID2 for binding to the polycomb repressive complex 2 core subunit SUZ12.

[Nature Communications] Researchers reported high levels of androgen receptor chromatin binding heterogeneity in human primary prostate tumors, that overlapped with heterogeneity observed in healthy prostate epithelium.

[Cancer Cell International] Five cohorts from The Cancer Genome Atlas and Gene Expression Omnibus databases were used to perform gene set variation analysis between nonrecurrent and recurrent prostate cancer patients.

[Journal of Proteome Research] The authors investigated the metabolic alterations induced by the Zika virus in prostate epithelial (PNT1a) and adenocarcinoma (PC-3) cells using an untargeted metabolomics approach and high-resolution mass spectrometry.

[Scientific Reports] Four different cell lines, including ACHN, 5637, LNCaP, and PC3 were exposed to diverse concentrations of mesenchymal stem cells-derived exosomes to find IC50 values.

[Scientific Reports] Scientists fabricated the Bismuth oxide (Bi2O3) nanoparticles, functionalized with glutamine and conjugated with Thiosemicarbazide, and then investigated their anticancer mechanism.

[BMC Cancer] Researchers found that LINC00852 was highly expressed in the tissue of prostate cancer using quantitative reverse transcription PCR. CCK-8 assay, colony formation experiment, Transwell migration, and invasion experiments were performed to prove that the upregulation of LINC00852 could promote the proliferation, migration, and invasion of prostate cancer cells in vitro.

[Biochemical and Biophysical Research Communications] Investigators examined the functional and biological roles of phosphorylation. Androgen receptor phosphorylation at Ser815 stabilized homodimer formation in the cytoplasm, interrupting DHT-response nuclear translocation.

[Heliyon] Two different cell models were employed and compared. Small extracellular vesicles from androgen-dependent prostate cancer (PCa) cells (LNCaP) and androgen-independent PCa cells (LNCaP-AI+F cells) were isolated and characterized.

[British Journal of Cancer] The authors discuss the main mesenchymal cell populations of the prostate stroma, highlighting their dynamic role in the transition of the healthy prostate epithelium to cancer.

[Biomerica, Inc.] Biomerica, Inc. announced it has submitted a 510(k) premarket notification to the US FDA for hp+detect™, a new product that detects the presence of the H. pylori bacteria, which infects approximately 35% of the US population.