Keep Current with the Latest in Cell Biology Research

Genome-Wide Gene Expression Analyses of BRCA1– and BRCA2-Associated Breast and Ovarian Tumors

To determine if gene expression analysis has been a successful approach for variant classification, the authors describe the design and comparability of 23 published gene expression studies that have profiled cells from BRCA1– and BRCA2 pathogenic variant carriers.
[Cancers]
Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-Wide Gene Expression Analyses of BRCA1- and BRCA2-Associated Breast and Ovarian Tumours. Cancers, 12(10), 3015. https://doi.org/10.3390/cancers12103015 Cite
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MammaPrint® Approved for Reimbursement in Germany

Agendia, Inc. announced that the Federal Joint Committee approved MammaPrint®, Agendia’s 70-Gene Breast Cancer Recurrence Assay.
[Agendia, Inc.]
Press Release
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Decellularized Extracellular Matrix Scaffolds Identify Full-Length Collagen VI as a Driver of Breast Cancer Cell Invasion in Obesity and Metastasis

The authors describe a method to study whole-tissue extracellular matrix (ECM) effects from disease states associated with metastasis on tumor cell phenotypes and identified the individual ECM proteins and signaling pathways that were driving these effects. They showed that decellularized ECM from tumor-bearing and obese mammary glands drives TNBC cell invasion.
[Science Advances]
Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis | Science Advances. (n.d.). Retrieved October 21, 2020, from https://advances.sciencemag.org/content/6/43/eabc3175 Cite
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The Molecular Basis of Mammary Gland Development and Epithelial Differentiation

Investigators provide an overview of the latest research in the single-cell genomics of mammary gland development, which may help to understand the lineage commitment of mammary stem cells into luminal or basal epithelial cells that constitute the mammary gland.
[Seminars in Cell & Developmental Biology]
Slepicka, P. F., Somasundara, A. V. H., & dos Santos, C. O. (2020). The molecular basis of mammary gland development and epithelial differentiation. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2020.09.014 Cite
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MicroRNA-941 Regulates the Proliferation of Breast Cancer Cells by Altering Histone H3 Ser 10 Phosphorylation

Researchers performed Affymetrix Gene Chip miRNA 4.0 microarray and observed differential regulation of miRNAs (75 upregulated and 199 downregulated) in metastatic MDA-MB-231 cells as compared to immortalized human non-tumorigenic breast epithelial cells.
[Scientific Reports]
Surapaneni, S. K., Bhat, Z. R., & Tikoo, K. (2020). MicroRNA-941 regulates the proliferation of breast cancer cells by altering histone H3 Ser 10 phosphorylation. Scientific Reports, 10(1), 17954. https://doi.org/10.1038/s41598-020-74847-7 Cite
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Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

The authors identified KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused pooled RNAi screen and confirmed the finding by using a genetically engineered mouse model based on conditional and melanocyte-specific deletion of KMT2D.
[Cell Reports]
Maitituoheti, M., Keung, E. Z., Tang, M., Yan, L., Alam, H., Han, G., Singh, A. K., Raman, A. T., Terranova, C., Sarkar, S., Orouji, E., Amin, S. B., Sharma, S., Williams, M., Samant, N. S., Dhamdhere, M., Zheng, N., Shah, T., Shah, A., … Rai, K. (2020). Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108293 Cite
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Response of Human Melanoma Cell Lines to Interferon-Beta Gene Transfer Mediated by a Modified Adenoviral Vector

The AdRGD-PG-hIFNβ vector encoding the human interferon-β cDNA was used to transduce human melanoma cell lines SK-MEL-05 and SK-MEL-147. In vitro, cell death was induced in more than 80% of the cells and correlated with elevated annexinV staining and caspase 3/7 activity.
[Scientific Reports]
David, T. I. P., Cerqueira, O. L. D., Lana, M. G., Medrano, R. F. V., Hunger, A., & Strauss, B. E. (2020). Response of human melanoma cell lines to interferon-beta gene transfer mediated by a modified adenoviral vector. Scientific Reports, 10(1), 17893. https://doi.org/10.1038/s41598-020-74826-y Cite
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Identification of Drivers of Breast Cancer Invasion by Secretome Analysis: Insight Into CTGF Signaling

Scientists combined data from secretome and proteome analysis using mass spectrometry with microarray data from mesenchymal transformed breast cancer cells to elucidate the drivers of epithelial-mesenchymal transition and cell invasion.
[Scientific Reports]
Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling | Scientific Reports. (n.d.). Retrieved October 21, 2020, from https://www.nature.com/articles/s41598-020-74838-8 Cite
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Guanosine Triphosphate Links MYC-Dependent Metabolic and Ribosome Programs in Small Cell Lung Cancer

Investigators demonstrated that primary MYCHigh human small cell lung cancer tumors contain abundant guanosine nucleotides.
[Journal of Clinical Investigation]
Huang, F., Huffman, K., Wang, Z., Wang, X., Li, K., Cai, F., Yang, C., Cai, L., Shih, T. S., Zacharias, L. G., Chung, A. S., Yang, Q., Chalishazar, M. D., Ireland, A. S., Stewart, C. A., Cargill, K. R., Girard, L., Liu, Y., Ni, M., … DeBerardinis, R. (2020). Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small cell lung cancer. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI139929 Cite
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Redox-Resistant SERCA Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice

Scientists hypothesized that sarco(endo)plasmic reticulum calcium ATPase oxidation at C674 would modulate the effects of reactive oxygen species on mitochondrial calcium and mitochondria-dependent apoptosis in cardiac myocytes.
[Circulation]
Goodman Jena B., Qin Fuzhong, Morgan Robert, Chambers Jordan M., Croteau Dominique, Siwik Deborah A., Hobai Ion, Panagia Marcello, Luptak Ivan, Bachschmid Markus, Tong Xiao Yong, Pimentel David R., Cohen Richard A., & Colucci Wilson S. (n.d.). Redox-Resistant SERCA Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.048183 Cite
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Phosphorylation of Msx1 Promotes Cell Proliferation through the Fgf9/18-MAPK Signaling Pathway during Embryonic Limb Development

Investigators demonstrated that Msh homeobox 1 (Msx1) promotes the proliferation of myoblasts and mesenchymal stem cells by enhancing mitogen-activated protein kinase (MAPK) signaling.
[Nucleic Acids Research]
Yang, Y., Zhu, X., Jia, X., Hou, W., Zhou, G., Ma, Z., Yu, B., Pi, Y., Zhang, X., Wang, J., & Wang, G. (n.d.). Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaa905 Cite
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