[MAIA Biotechnology, Inc.] MAIA Biotechnology, Inc. announced that it has reached an enrollment milestone with 150 patients treated with ateganosine sequenced with an immune checkpoint inhibitor in the ongoing Phase 2 and pivotal Phase 3 clinical trials of its novel telomere-targeting agent ateganosine as a treatment for NSCLC.

[Nature] Investigators generated long-term adult human distal lung organoids from intact tissue fragments in 3D air–liquid interface culture, which co-preserved epithelial and stromal components with endogenous lung-resident immune cells.

[Nature] Scientists developed dual-recombinase-mediated lineage-tracing techniques in mice to demonstrate that alveolar type 2 cells migrate into injured bronchioles and transdifferentiate into club cells and ciliated cells, thereby actively contributing to airway regeneration.

[Journal of advanced research] Investigators aimed to identify potential uridine-associated targets in pulmonary fibrosis and to determine whether uridine is associated with matrix metalloproteinase 7 (MMP7)-related immune cell infiltration.

[Angiogenesis] Researchers identified the vascular endothelial growth factor (VEGF)-A splice variant VEGF165b as a crucial endogenous protector against acute lung injury/acute respiratory distress syndrome.

[Cellular Signalling] Scientists investigated the crosstalk between sequestosome 1 (SQSTM1/p62) and nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating cellular senescence and epithelial-mesenchymal transition (EMT) in inorganic arsenic (As)-exposed alveolar type II cells.

[Toxicology] The authors investigated the impact of heated cigarette smoke extract (CSE) on human bronchial epithelial BEAS-2B cells and their released extracellular vesicles, comparing the results with those previously reported for burned CSE.

[Proceedings of the National Academy of Sciences of the United States of America] Using normal lung organoids, investigators defined how chronic cigarette smoke condensate exposure drives two separate stem cell populations to evolve premalignant states harboring progressive epigenetic and linked transcriptomic abnormalities in the absence of major driver mutations.

[Journal for Immunotherapy of Cancer] Researchers sought to identify tumor-intrinsic mediators of KRAS-driven immune evasion and therapeutic resistance in lung adenocarcinoma by defining the role of proteinase 3 (PRTN3) in immune regulation, its regulation and function, and the therapeutic effect of its inhibition.

[Pharmacological Research] Scientists identified a previously unrecognized exosomal long non-coding RNA–mediated immunoregulatory axis targeted by the natural compound Ophiopogonin D in NSCLC.

[Molecular Oncology] Investigators elucidated the role of epithelial cell adhesion molecule (EpCAM), a critical signaling molecule, in drug resistance and its mechanistic association with AXL, a receptor tyrosine kinase.

[Respiratory Research] In this study, by integrating bioinformatics analysis and experimental validation, scientists investigated the role of the proprotein convertase FURIN in promoting malignant phenotypes of lung adenocarcinoma and explored its potential regulatory mechanisms in ferroptosis.