Keep Current with the Latest in Cell Biology Research

Black Phosphorus-Based Nanoparticles Induce Liver Cancer Cell Mitochondrial Apoptosis and Immune Cell Tumor Infiltration for Enhancing Dendritic Cell Therapy

[Heliyon] The authors proposed a novel approach utilizing a combination of dendritic cell-based cellular immunotherapy and a photothermal nanoadjuvant black phosphorus nanoparticles.

CD20 CAR T-Cells Safely and Reversibly Ablate B-Cell Follicles in a Nonhuman Primate Model of HIV Persistence

[Molecular Therapy] In simian/human immunodeficiency virus (SHIV)-infected animals, CAR T cells were highly functional with rapid expansion and trafficking to tissue-associated viral sanctuaries including B cell follicles and gut-associated lymphoid tissues.

Stem Cell-Derived CAR T Cells Show Greater Persistence, Trafficking, and Plasma Viral Control Compared to Ex Vivo Transduced CAR T Cells In Vivo

[Molecular Therapy] Using the humanized bone marrow/liver/thymus mouse model and nonhuman primate model of HIV infection, scientists evaluated two CAR-based gene therapy approaches.

Nonsignaling Extracellular Spacer Regulates Tumor Antigen Selectivity of CAR T Cells

[Molecular Therapy Oncology] Investigators developed a CAR T cell therapy targeting prostate stem cell antigen for prostate and pancreatic cancers, showing improved pre-clinical antitumor activity and T cell persistence by optimizing the intracellular co-stimulatory domain.

Idecabtagene Vicleucel Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple Myeloma With Renal Impairment

[Haematologica] Scientists evaluated patients with relapsed multiple myeloma with renal impairment treated with standard of care idecabtagene vicleucel, as outcomes with CAR T cell therapy are unknown in this population.

Emerging Strategies for Nanomedicine in Autoimmunity

[Advanced Drug Delivery Reviews] Investigators focus on leveraging the power of nanomedicine for prevalent autoimmune disorders throughout the body. They expand on three key areas for the development of autoimmunity therapies— avoiding systemic immunosuppression, balancing interactions with the immune system, and elevating current platforms for delivering complex cargoes.

CAR T Therapies in Multiple Myeloma: Unleashing the Future

[Cancer Gene Therapy] Ongoing preclinical and clinical trials are exploring the capabilities of CAR T cells in targeting specific antigens on myeloma cells, offering hope for patients with relapsed/refractory multiple myeloma.

Activated Mesenchymal Stem/Stromal Cells Promote Myeloid Cell Differentiation via CCL2/CCR2 Signaling

[Stem Cell Reports] The authors explored the impact of MSCs on the differentiation of hematopoietic stem/progenitor cells and progenitors through the C-C motif chemokine CCL2/CCR2 signaling pathway.

Osr1-Mediated Mesothelial Transition of Liver Mesenchymal Cells Exacerbates Fibrotic Liver Damage

[Molecular Therapy] Single-cell RNA sequencing with in vivo lineage tracing in non-alcoholic steatohepatitismodel mice reveals a subpopulation of HSCs transitioning back to a state resembling their developmental precursors, mesothelial cells, after liver injury.

Endovascular Transplantation of mRNA-Enhanced Mesenchymal Stromal Cells Results in Superior Therapeutic Protein Expression in Swine Heart

[Molecular Therapy-Methods & Clinical Development] Using a trans-vessel wall device, investigators delivered chemically modified mRNAs and mRNA-enhanced mesenchymal stromal cells expressing Vascular Endothelial Growth Factor A directly to the heart.

Single-Cell Guided Prenatal Derivation of Primary Fetal Epithelial Organoids from Human Amniotic and Tracheal Fluids

[Nature Medicine] Using single-cell analysis, scientists characterized the cellular identities present in human amniotic fluid. Researchers identified and isolated viable epithelial stem/progenitor cells of fetal gastrointestinal, renal and pulmonary origin.

Lactate-Driven Type I Collagen Deposition Facilitates Cancer Stem Cell-Like Phenotype of Head and Neck Squamous Cell Carcinoma

[iScience] Scientists found that lactate increased CSC characteristics of head and neck squamous cell carcinoma by influencing the deposition of type I collagen (Col I). Lactate promoted Col I deposition through two distinct pathways.

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