Keep Current with the Latest in Cell Biology Research

Mapping the Chromatin Accessibility Landscape of Zebrafish Embryogenesis at Single-Cell Resolution by SPATAC-Seq

[Nature Cell Biology] Using SPATAC-seq, scientists profiled chromatin accessibility in more than 800,000 individual nuclei across 20 developmental stages spanning the sphere stage to the early larval protruding mouth stage.

Long-Term Culture of Human Pluripotent Stem Cells in Xeno-Free Condition Using Functional Polymer Films

[Advanced Materials] Scientists engineered a fully synthetic, xeno-free culture substrate, whose surface composition was tailored systematically for xeno-free culture of hPSCs.

Sequence-to-Expression Approach to Identify Etiological Non-Coding DNA Variations in P53 and cMYC-Driven Diseases

[Human Molecular Genetics] Researchers designed in vitro experiments to uncover the significance of occupancy and competitive binding between P53 and cMYC on common target genes.

PRC2-AgeIndex as a Universal Biomarker of Aging and Rejuvenation

[Nature Communications] The authors showed that low-methylated regions which were highly bound by polycomb repressive complex 2 (PRC2) in embryonic stem cells gained methylation with age in all examined somatic mitotic cells.

Reevaluation by the CRISPR/Cas9 Knockout Approach Revealed That Multiple Pluripotency-Associated lncRNAs Are Dispensable for Pluripotency Maintenance While Snora73a/B Is Essential for Pluripotency Exit

[Science China Life Sciences] Investigators employed CRISPR/Cas9-mediated knockout technology to explore the functions of eight lncRNAs previously reported to promote pluripotency in mouse ESCs.

The Differential Developmental Neurotoxicity of Valproic Acid on Anterior and Posterior Neural Induction of Human Pluripotent Stem Cells

[International Journal of Stem Cells] Researchers investigated the effects of valproic acid in a model where human pluripotent stem cells differentiate into anterior or posterior neural tissues.

O-GlcNAcase Regulates Pluripotency States of Human Embryonic Stem Cells

[Stem Cell Reports] Scientists showed that naive hESCs displayed lower levels of O-linked N-acetylglucosamine than primed hESCs.

Efficient and Reproducible Generation of Human iPSC-Derived Cardiomyocytes and Cardiac Organoids in Stirred Suspension Systems

[Nature Communications] The authors reported a robust stirred suspension cardiac differentiation protocol and performed extensive morphological and functional characterization of the resulting bioreactor-differentiated iPSC-cardiomyocytes.

Polycomb Function in Early Mouse Development

[Cell Death & Differentiation] Scientists discuss the functions and molecular mechanisms of both polycomb repressive complex 1 (PRC1) and PRC2 during early mouse embryo development, integrating new studies with existing knowledge.

Pioneering Code of Practice Released for Use of Stem Cell-Based Embryo Models in Research

[The University of Cambridge] The University of Cambridge, in partnership with the Progress Educational Trust, has led work to create the first ever UK guidelines for the generation and use of stem cell-based embryo models in research.

Research Progress on the Immunological Functions of Piezo1 a Receptor Molecule That Responds to Mechanical Force

[International Immunopharmacology] The authors explore the physiological functions and regulatory mechanisms of Piezo1 and its impact on innate and adaptive immunity. This may offer new insights into diagnostics and therapeutics for the prevention and treatment of diseases and surgical infections.

The Role of Chimeric Antigen Receptor T Cell Therapy in Immune-Mediated Neurological Diseases

[Annals of Neurology] Scientists present the state-of-the-art and future directions of the use of CAR-T in immune-mediated neurological dieases

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