Keep Current with the Latest in Cell Biology Research

CREB3L4 Promotes Angiogenesis and Tumor Progression in Gastric Cancer through Regulating VEGFA Expression

The upregulation of CREB3L4 in gastic cancer cells increased cell viability, promoted cell proliferation, reduced apoptosis, enhanced cell migration and invasion, and induced the formation of tubule-like endothelial structures, whereas CREB3L4 knockdown impeded tumor cell growth, attenuated cell motility, and prevented human umbilical vein endothelial cells from forming tubule-like structures.
[Cancer Gene Therapy]
Wang, N., Chen, Y., Shi, C., Lin, Z., & Xie, H. (2021). CREB3L4 promotes angiogenesis and tumor progression in gastric cancer through regulating VEGFA expression. Cancer Gene Therapy, 1–12. https://doi.org/10.1038/s41417-021-00305-9 Cite
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Injectable Hydrogel with MSNs/microRNA-21-5p Delivery Enables Both Immunomodification and Enhanced Angiogenesis for Myocardial Infarction Therapy in Pigs

Scientists developed a microRNA-21-5p delivery system using functionalized mesoporous silica nanoparticles with additional intrinsic therapeutic effects.
[Science Advances]
Li, Y., Chen, X., Jin, R., Chen, L., Dang, M., Cao, H., Dong, Y., Cai, B., Bai, G., Gooding, J. J., Liu, S., Zou, D., Zhang, Z., & Yang, C. (2021). Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Science Advances, 7(9), eabd6740. https://doi.org/10.1126/sciadv.abd6740 Cite
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FGF21 Promotes Ischaemic Angiogenesis and Endothelial Progenitor Cells Function under Diabetic Conditions in an AMPK/NAD+-Dependent Manner

The in vivo results showed that FGF21 efficiently improved blood perfusion and ischaemic angiogenesis in both type 1 and type 2 diabetic mice, and these effects were accompanied by enhanced endothelial progenitor cells mobilization and infiltration into ischaemic muscle tissues and increases in plasma stromal cell–derived factor‐1 concentration.
[Journal of Cellular and Molecular Medicine]
Dai, Q., Fan, X., Meng, X., Sun, S., Su, Y., Ling, X., Chen, X., Wang, K., Dai, X., Zhang, C., Da, S., Zhang, G., Gu, C., Chen, H., He, J., Hu, H., Yu, L., Pan, X., Tan, Y., & Yan, X. (n.d.). FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16369 Cite
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Tetraspanin18 Regulates Angiogenesis through VEGFR2 and Notch Pathways

The authors determined that Tspan18, a member of the Tetraspanin family, was expressed in developing vessels but not in mature vasculature in zebrafish and mouse wound healing. Reduction at Tspan18 level resulted in aberrant vascular patterning, impaired vessel stability and defective arterial–venous specification.
[Biology Open]
Li, G. X., Zhang, S., Liu, R., Singh, B., Singh, S., Quinn, D. I., Crump, G., & Gill, P. S. (2021). Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open, 10(2). https://doi.org/10.1242/bio.050096 Cite
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Single-Cell Transcriptomic Profiling and Characterization of Endothelial Progenitor Cells: New Approach for Finding Novel Markers

Scientists assembled five groups of chosen endothelial progenitor cells (EPCs)-related genes/factors using PubMed literature and Gene Ontology databases. This shortened database of EPC factors was fed into publically published transcriptome matrix to compare their expression between endothelial colony-forming cells, HUVECs, and two adult endothelial cell types from the skin and adipose tissue.
[Stem Cell Research & Therapy]
Abdelgawad, M. E., Desterke, C., Uzan, G., & Naserian, S. (2021). Single-cell transcriptomic profiling and characterization of endothelial progenitor cells: new approach for finding novel markers. Stem Cell Research & Therapy, 12(1), 145. https://doi.org/10.1186/s13287-021-02185-0 Cite
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Multiphoton‐Guided Creation of Complex Organ‐Specific Microvasculature

Multiphoton ablation combined with guided endothelial cell growth from pre‐formed microvessels was used to successfully create perfusable and cellularized organ‐specific microvascular structures at anatomic scale within collagen hydrogels.
[Advanced Healthcare Materials]
Rayner, S. G., Howard, C. C., Mandrycky, C. J., Stamenkovic, S., Himmelfarb, J., Shih, A. Y., & Zheng, Y. (n.d.). Multiphoton-Guided Creation of Complex Organ-Specific Microvasculature. Advanced Healthcare Materials, n/a(n/a), 2100031. https://doi.org/https://doi.org/10.1002/adhm.202100031 Cite
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PIWIL1 Governs the Crosstalk of Cancer Cell Metabolism and Immunosuppressive Microenvironment in Hepatocellular Carcinoma

The authors reported the novel of tumor cell-expressed Piwi Like RNA-Mediated Gene Silencing 1 (PIWIL1) in mediating the crosstalk of fatty acid metabolism and immune response of human hepatocellular carcinoma.
[Signal Transduction and Targeted Therapy]
Wang, N., Tan, H.-Y., Lu, Y., Chan, Y.-T., Wang, D., Guo, W., Xu, Y., Zhang, C., Chen, F., Tang, G., & Feng, Y. (2021). PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-021-00485-8 Cite
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New Positive Data from Can-Fite’s Liver Cancer Phase II Clinical Study with Namodenoson

Can-Fite BioPharma Ltd. announced new data from the Phase II advanced liver cancer study including overall survival of nearly 4 years in two patients who are under namodenoson treatment.
[Can-Fite BioPharma Ltd.]
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Peter Lougheed Centre Joins the Phase II Trial of LSALT Peptide for the Treatment of Complications in Hospitalized COVID-19 Patients

Arch Biopartners, Inc. announced that the Peter Lougheed Center in Calgary, Alberta has joined the Phase II trial of its lead drug LSALT peptide, targeting the prevention of acute lung injury, acute kidney injury, and other complications caused by inflammation in hospitalized patients with moderate to severe cases of COVID-19.
[Arch Biopartners, Inc.]
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Considering the Potential for Gene-Based Therapy in Prostate Cancer

Evaluation of research and clinical trials in gene therapy reveals a concentration of activity in prostate cancer research and practice.
[Nature Reviews Urology]
Gregg, J. R., & Thompson, T. C. (2021). Considering the potential for gene-based therapy in prostate cancer. Nature Reviews Urology, 1–15. https://doi.org/10.1038/s41585-021-00431-x Cite
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LONP1 and ClpP Cooperatively Regulate Mitochondrial Proteostasis for Cancer Cell Survival

Researchers identified functional crosstalk between LONP1 and ClpP, two mitochondrial matrix proteases that cooperate to attenuate proteotoxic stress and protect mitochondrial functions for cancer cell survival.
[Oncogenesis]
Lee, Y. G., Kim, H. W., Nam, Y., Shin, K. J., Lee, Y. J., Park, D. H., Rhee, H.-W., Seo, J. K., & Chae, Y. C. (2021). LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival. Oncogenesis, 10(2), 1–14. https://doi.org/10.1038/s41389-021-00306-1 Cite
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