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Sangamo Announces Global Collaboration with Novartis to Develop Genomic Medicines for Autism and other Neurodevelopmental Disorders

Sangamo Therapeutics, Inc. announced that it has executed a global licensing collaboration agreement with Novartis to develop and commercialize gene regulation therapies to address three neurodevelopmental targets, including autism spectrum disorder and other neurodevelopmental disorders.
[Sangamo Therapeutics]
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Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome

The authors focus on the therapeutic potential of mesenchymal stem/stromal cells (MSCs). MSCs are available from several tissues, including bone marrow, umbilical cord, and adipose tissue.
[Seminars in Respiratory and Critical Care Medicine]
Byrnes, D., Masterson, C. H., Artigas, A., & Laffey, J. G. (2020). Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome. Seminars in Respiratory and Critical Care Medicine. https://doi.org/10.1055/s-0040-1713422 Cite
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Celularity Announces the Activation of First California Clinical Trial Site following CIRM Grant Award to Advance Treatments for COVID-19

Celularity announced that it has been awarded a $750,000 COVID-19 Project grant by the California Institute for Regenerative Medicine (CIRM), one of the three clinical awards targeting the coronavirus. This grant will support California Institutions participating in the Phase I/II clinical trial of human placental hematopoietic stem cell derived natural killer cells for the treatment of adults with COVID-19.
[Celularity Inc.]
Press Release

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Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes

To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
Liu, C., Kang, L.-N., Chen, F., Mu, D., Shen, S., Wang, K., Hu, J.-X., Xie, J., & Xu, B. (2020). Immediate intracoronary delivery of human umbilical cord mesenchymal stem cells reduces myocardial injury by regulating the inflammatory process via cell-cell contact with T lymphocytes. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0264 Cite
Abstract

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Broccoli Extract Increases Drug-Mediated Cytotoxicity towards Cancer Stem Cells of Head and Neck Squamous Cell Carcinoma

Researchers investigated whether sulforaphane could enhance the chemotherapeutic effects of cisplatin and 5-fluorouracil against head and neck squamous cell carcinomas–cancer stem cells, and its mechanisms of action.
[British Journal of Cancer]
Elkashty, O. A., & Tran, S. D. (2020). Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-1025-1 Cite
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Increased FGF-23 Levels Are Linked to Ineffective Erythropoiesis and Impaired Bone Mineralization in Myelodysplastic Syndromes

Researchers showed that myelodysplastic NUP98‑HOXD13 transgenic mice displayed an abnormally high number of osteoblasts, yet a higher fraction of nonmineralized bone, indicating delayed bone mineralization. This was accompanied by high fibroblast growth factor-23 serum levels, a phosphaturic hormone that inhibits bone mineralization and erythropoiesis.
[JCI Insight]
Weidner, H., Baschant, U., Lademann, F., Colunga, M. G. L., Balaian, E., Hofbauer, C., Misof, B. M., Roschger, P., Blouin, S., Richards, W. G., Platzbecker, U., Hofbauer, L. C., & Rauner, M. (2020). Increased FGF-23 levels are linked to ineffective erythropoiesis and impaired bone mineralization in myelodysplastic syndromes. JCI Insight, 5(15). https://doi.org/10.1172/jci.insight.137062 Cite
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Ocugen Receives Fourth FDA Orphan Drug Designation for the Same Product, OCU400 (AAV-NR2E3) Gene Therapy, for the Treatment of Another Key Inherited Retinal Disease (IRD), PDE6B Gene Mutation-Associated Retinal Diseases

Ocugen, Inc. announced the FDA granted the fourth Orphan Drug Designation for OCU400 in the treatment of PDE6B gene mutation-associated retinal diseases.
[Ocugen, Inc.]
Press Release

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LC3B Upregulation by NANOG Promotes Immune Resistance and Stem-Like Property through Hyperactivation of EGFR Signaling in Immune-Refractory Tumor Cells

Scientists report that the emergence of refractory phenotypes was highly associated with an aberrant macroautophagic/autophagic state of NANOG+ tumor cells and that the autophagic phenotype arises through transcriptional induction of MAP1LC3B/LC3B by NANOG.
[Autophagy]
Kim, S., Cho, H., Hong, S.-O., Oh, S. J., Lee, H.-J., Cho, E., Woo, S. R., Song, J. S., Chung, J.-Y., Son, S. W., Yoon, S. M., Jeon, Y.-M., Jeon, S., Yee, C., Lee, K.-M., Hewitt, S. M., Kim, J.-H., Song, K.-H., & Kim, T. W. (2020). LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1805214 Cite
Abstract

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DRP1 Promotes Lactate Utilization in KRAS‐Mutant Non‐Small Cell Lung Cancer Cells

Scientists developed a lactate‐dependent cell proliferation assay and found that dynamin‐related protein (DRP1), which was highly expressed in KRAS‐mutant non‐small cell lung cancer (NSCLC), was required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.
[Cancer Science]
Hu, M., Zhao, Y., Cao, Y., Tang, Q., Feng, Z., Ni, J., & Zhou, X. (n.d.). DRP1 promotes lactate utilization in KRAS-mutant non-small cell lung cancer cells. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14603 Cite
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Acute Alcohol Intoxication Impairs SHH‐Gli1 Signaling and Activation of Primitive Hematopoietic Precursor Cells in the Early Stage of Host Response to Bacteremia

Investigators determined the effect of alcohol exposure on sonic hedgehog signaling in the regulation of hematopoietic stem cell activation during bacteremia.
[Alcoholism-Clinical and Experimental Research]
Shi, X., Simms, K. J., & Zhang, P. (n.d.). Acute Alcohol Intoxication Impairs SHH-Gli1 Signaling and Activation of Primitive Hematopoietic Precursor Cells in the Early Stage of Host Response to Bacteremia. Alcoholism: Clinical and Experimental Research, n/a(n/a). https://doi.org/10.1111/acer.14429 Cite
Abstract

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High Expression of NEK2 Promotes Lung Cancer Progression and Drug Resistance and Is Regulated by Mutant EGFR

Elevated never in mitosis gene A-related kinase 2 level promoted the rapid cell cycle progression and favors the rapid proliferation of epidermal growth factor receptor-mutant non-small cell lung cancer cells.
[Molecular and Cellular Biochemistry]
Chen, C., Peng, S., Li, P., Ma, L., & Gan, X. (2020). High expression of NEK2 promotes lung cancer progression and drug resistance and is regulated by mutant EGFR. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03854-z Cite
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Synergy between Amyloid-β and Tau in Alzheimer’s Disease

The authors highlight the latest evidence base pertaining to the complex Aβ–tau interaction and underscore its crucial importance to elucidating disease pathogenesis and the design of next-generation Alzheimer’s disease therapeutic trials.
[Nature Neuroscience]
Busche, M. A., & Hyman, B. T. (2020). Synergy between amyloid-β and tau in Alzheimer’s disease. Nature Neuroscience, 1–11. https://doi.org/10.1038/s41593-020-0687-6 Cite
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