The upregulation of CREB3L4 in gastic cancer cells increased cell viability, promoted cell proliferation, reduced apoptosis, enhanced cell migration and invasion, and induced the formation of tubule-like endothelial structures, whereas CREB3L4 knockdown impeded tumor cell growth, attenuated cell motility, and prevented human umbilical vein endothelial cells from forming tubule-like structures.
[Cancer Gene Therapy]
Wang, N., Chen, Y., Shi, C., Lin, Z., & Xie, H. (2021). CREB3L4 promotes angiogenesis and tumor progression in gastric cancer through regulating VEGFA expression. Cancer Gene Therapy, 1–12. https://doi.org/10.1038/s41417-021-00305-9 Cite
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