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The Prostate Cancer Foundation Announces Inaugural $30 Million TACTICAL Awards Program for Innovative Prostate Cancer Research

[Prostate Cancer Foundation] The Prostate Cancer Foundation announced four inaugural Class of 2022 TACTICAL Award recipients. This $30 million program will support cross-disciplinary pioneering research toward the goal of developing 21st Century therapies for the most life-threatening form of prostate cancer.

PALI1 Promotes Tumor Growth through Competitive Recruitment of PRC2 to G9A-Target Chromatin for Dual Epigenetic Silencing

[Molecular Cell] Scientists reported that PALI1 was upregulated in advanced prostate cancer and competed with JARID2 for binding to the polycomb repressive complex 2 core subunit SUZ12.

Extensive Androgen Receptor Enhancer Heterogeneity in Primary Prostate Cancers Underlies Transcriptional Diversity and Metastatic Potential

[Nature Communications] Researchers reported high levels of androgen receptor chromatin binding heterogeneity in human primary prostate tumors, that overlapped with heterogeneity observed in healthy prostate epithelium.

Identification and Validation of an E2F-Related Gene Signature for Predicting Recurrence-Free Survival in Human Prostate Cancer

[Cancer Cell International] Five cohorts from The Cancer Genome Atlas and Gene Expression Omnibus databases were used to perform gene set variation analysis between nonrecurrent and recurrent prostate cancer patients.

Unraveling the Metabolic Alterations Induced by Zika Infection in Prostate Epithelial (PNT1a) and Adenocarcinoma (PC-3) Cell Lines

[Journal of Proteome Research] The authors investigated the metabolic alterations induced by the Zika virus in prostate epithelial (PNT1a) and adenocarcinoma (PC-3) cells using an untargeted metabolomics approach and high-resolution mass spectrometry.

The Effect of Mesenchymal Stem Cells-Derived Exosomes on the Prostate, Bladder, and Renal Cancer Cell Lines

[Scientific Reports] Four different cell lines, including ACHN, 5637, LNCaP, and PC3 were exposed to diverse concentrations of mesenchymal stem cells-derived exosomes to find IC50 values.

Synthesize of Bi2O3/Gln-TSC Nanoparticles and Evaluation of Their Toxicity on Prostate Cancer Cells and Expression of CASP8, BAX, and Bcl-2 Genes

[Scientific Reports] Scientists fabricated the Bismuth oxide (Bi2O3) nanoparticles, functionalized with glutamine and conjugated with Thiosemicarbazide, and then investigated their anticancer mechanism.

The LINC00852/miR-29a-3p/JARID2 Axis Regulates the Proliferation and Invasion of Prostate Cancer Cell

[BMC Cancer] Researchers found that LINC00852 was highly expressed in the tissue of prostate cancer using quantitative reverse transcription PCR. CCK-8 assay, colony formation experiment, Transwell migration, and invasion experiments were performed to prove that the upregulation of LINC00852 could promote the proliferation, migration, and invasion of prostate cancer cells in vitro.

Ser815 Phosphorylation Stabilizes the Androgen Receptor Homodimer and Stimulates ER-Stress Induced Cell Death

[Biochemical and Biophysical Research Communications] Investigators examined the functional and biological roles of phosphorylation. Androgen receptor phosphorylation at Ser815 stabilized homodimer formation in the cytoplasm, interrupting DHT-response nuclear translocation.

Prostate Cancer Small Extracellular Vesicles Participate in Androgen-Independent Transformation of Prostate Cancer by Transferring let-7a-5p

[Heliyon] Two different cell models were employed and compared. Small extracellular vesicles from androgen-dependent prostate cancer (PCa) cells (LNCaP) and androgen-independent PCa cells (LNCaP-AI+F cells) were isolated and characterized.

Stromal Cells in Prostate Cancer Pathobiology: Friends or Foes?

[British Journal of Cancer] The authors discuss the main mesenchymal cell populations of the prostate stroma, highlighting their dynamic role in the transition of the healthy prostate epithelium to cancer.

Sosei Heptares Enters R&D Agreements with the University of Oxford and KU Leuven to Identify and Validate Key GPCRs Driving Gastrointestinal and Immune Disorders

[Biomerica, Inc.] Biomerica, Inc. announced it has submitted a 510(k) premarket notification to the US FDA for hp+detect, a new product that detects the presence of the H. pylori bacteria, which infects approximately 35% of the US population.

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