[FDA] The FDA has received reports of T cell malignancies, including chimeric antigen receptor CAR-positive lymphoma, in patients who received treatment with BCMA- or CD19-directed autologous CAR T cell immunotherapies.

[Nature Biomedical Engineering] Investigators showed that replacement of the extracellular domains of heterodimeric cytokine receptors in T cells with two leucine zipper motifs provided optimal Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling.

[blood] The authors presented the clinicogenomic characterization of a CARTITUDE-4 patient who developed a CAR+ T cell lymphoma post cilta-cel. Diagnostic and staging workup included biopsy analyses and FDG-PET scan.

[Cell Stem Cell] Scientists reported the analysis of one year of data from the first cohort of 15 patients enrolled in an open-label, first-in-human, dose-escalation Phase I study to determine the feasibility, safety, and tolerability of the transplantation of allogeneic human neural stem/progenitor cells for the treatment of secondary progressive multiple sclerosis.

[Science Advances] Researchers demonstrated that EpCAM–CAR-T cells costimulated by Dectin-1 exhibited robust antitumor activity without adverse effects in xenograft mouse models and EpCAM-humanized mice.

[Science Advances] Scientists described an approach using platelet-optimized lipid nanoparticles containing mRNA to enable exogenous protein expression in human and rat platelets.

[Haematologica] Investigators performed targeted DNA sequencing of 457 hematopoietic stem cell grafts collected for autologous stem cell transplantation in myeloma patients and correlated their findings with high-dimensional longitudinal clinical and laboratory data.

[Lab Animal] Researchers identified cathepsin E (Ctse) as the most differentially expressed gene between CD8+ T cells of B6 and B6.SJL and demonstrated that the differences reported between these two mouse strains were not due to CTSE.

[iScience] Investigators demonstrated that invariant NKT (iNKT) cells could be efficiently expanded using modified cytokines combination from peripheral blood mononuclear cells.

[The Journal of Gene Medicine] The authors provide an overview of current preclinical approaches in that lipid nanoparticle surface modification was leveraged for cell and tissue targeting by conjugating aptamers, antibodies, and peptides among others.

[Nature Genetics] To identify noncoding regions with accessible chromatin that associate with cell-state-defining gene expression patterns, researchers leveraged multimodal single-nucleus RNA and assay for transposase-accessible chromatin sequencing data across 28,674 cells from the inflamed synovial tissue of 12 donors.

[Nature] The authors generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in human, mouse, and the marsupial opossum.