[Molecular Targeting Technologies, Inc. (BioSpace)] Molecular Targeting Technologies, Inc. (MTTI) announced that it has been awarded a $3.17 million, five-year National Cancer Institute grant to advance the development of ¹⁷⁷Lu-EBRGD, an investigational radiopharmaceutical targeting integrin αvβ3, for NSCLC.

[Puma Biotechnology, Inc.] Puma Biotechnology, Inc. announced the initiation of its ALISertib in CAncer (ALISCA®-Lung2) Phase II trial of alisertib in combination with paclitaxel for the treatment of patients with advanced small cell lung cancer.

[bioAffinity Technologies, Inc.] bioAffinity Technologies, Inc. announced that the Hong Kong Intellectual Property Department has granted a patent for the Company’s proprietary platform technology for predicting the likelihood of lung cancer using flow cytometry and fluorescent markers to characterize cell populations in sputum.

[Nature Communications] The authors identified activation of the de novo pathway of pyrimidine synthesis as a central contributor of CF lung remodeling.

[Science Advances] Scientists showed that secreted ORF8, a SARS-CoV-2 accessory protein, drives inflammatory lung pathology by increasing macrophage permissiveness to infection, triggering pyroptosis, and amplifying viral replication in alveolar epithelial cells.

[Ecotoxicology and Environmental Safety] Researchers investigated the effects and underlying mechanisms of phthalic acid (PTA) on pulmonary fibrogenesis using human lung fibroblast IMR-90 cells chronically exposed to environmentally relevant concentrations of PTA (0–60 μg/L) for 14 days.

[Chinese Medical Journal] The authors investigated the relationship between B-cell receptor-associated protein 31 (BAP31) and ferroptosis in acute lung injury by administering lipopolysaccharide directly into the lungs of both wild-type mice and transgenic mice overexpressing BAP31, followed by collection of lung tissues 24 h post-injection for transcriptomic analysis.

[Journal of Natural Medicines] Scientists investigated the effects of ginsenoside Rd on primary normal human bronchial epithelial cells cultured under air–liquid interface conditions.

[Cancer Cell] Investigators demonstrated that γδ T cells are effective at tarlatamab (delta-like ligand 3-CD3 bispecific T cell engager)-redirected small cell lung cancer (SCLC) killing and that zoledronate, an FDA-approved compound, can sensitize SCLC cells to γδ T cell-mediated killing

[Science translational medicine] Scientists found that SCRMP, a SCLC cisplatin resistance–associated microprotein, was up-regulated in cisplatin-resistant SCLC tissues and cell lines, and its elevated expression strongly correlated with impaired platinum response and unfavorable survival outcomes in patients.

[Science Advances] Researchers showed that epidermal growth factor receptor (EGFR) inhibition in EGFR-mutated lung cancer transiently down-regulates tyrosyl-DNA phosphodiesterase 1 (TDP1), a repair enzyme that resolves abortive topoisomerase I cleavage complexes (TOP1ccs).

[Pharmaceutical Research] The authors seek to critically synthesize the available scientific data on biosurfactants as potential therapeutic agents for improving lung function and modulating inflammatory processes in the respiratory diseases.