[Nature Communications] Researchers uncovered human-specific mechanisms that govern α and β cell fate allocation, advancing the generation of stem cell-derived islets for diabetes research and cell therapy.

[European Journal of Pharmacology] Scientists showed that trichostatin A alleviates acute pancreatitis by restoring autophagic flux through modulation of the ERK/FoxO3a signaling pathway.

[Gut] Investigators identified a GSK3β^high/NFATc1^high subtype of pancreatic cancer that drives DNA repair and cisplatin resistance, revealing a targetable vulnerability for precision therapy.

[Gut] The authors revealed that LY6D marks a persistent gastric-like cell state that drives pancreatic cancer initiation and metastasis.

[Molecular Cell] Scientists demonstrated that histone deacetylase 5 (HDAC5) mediates the deacetylation of forkhead box A1 (FOXA1) at lysine residue 270, leading to repression of FOXA1’s global chromatin occupancy.

[Oncogene] Researchers investigated whether DNA methyltransferase 3 beta (DNMT3B) is a novel splicing target of epithelial splicing regulatory proteins 1 (ESRP1) and the alteration of isoform pattern determines the aggressiveness of pancreatic cancer.

[Cell Communication and Signaling] Investigators aimed to elucidate the functional roles of these proteins in collective invasion and PDAC metastasis.

[Cell Biology and Toxicology] The authors identified that S100A11 (K3, K55) and ANXA2 are significantly lactylated in PDAC tissues. Lactate-induced lactylation of S100A11 at K3 and K55 inhibits FBXW11-mediated ubiquitination and proteasomal degradation, thereby stabilizing the protein.

[PloS One] Scientists showed that lactate-induced lactylation drives pancreatic cancer metastasis by stabilizing the S100A11/ANXA2 membrane repair complex.

[Cancer Biology & Therapy] The authors highlight how integrated single-cell and spatial transcriptomics are transforming the study of pancreatic cancer, revealing tumor microenvironment complexity and advancing precision oncology.

[] EMA’s human medicines committee (CHMP) has started a phased review of data on daraxonrasib, a medicine intended for the treatment of metastatic pancreatic cancer. A phased review aims to accelerate the assessment of a medicine by evaluating the data in phases, as they become available.

[Cell Research] Investigators reported the development of a defined, serum-free culture system, termed 6iL/E4, that enables the derivation and long-term self-renewal of ESCs across diverse mammalian species.