[Cancer Research] Researchers demonstrated that age engenders the development of an immunosuppressive tumor microenvironment, which is linked to phenotypes associated with melanoma metastasis.

[Nature Aging] Researchers provide a review of the interactions between skin exposure, aging hallmarks in the skin, and associated systemic changes, and their implications in treatment and disease.

[Human Molecular Genetics] Scientists showed that SK-MEL-28 SNCA-knockout cells relative to control cells exhibit an (i) increased density of endolysosomes; (ii) increased perinuclear positioning of large endolysosomes; and (iii) decreased levels of the tetraspanins CD9 and CD81.

[ACS Nano] Researchers proposed a strategy to prevent secondary brain injury and complications by modulating immunity and ECM remodeling.

[Cancer Research] Scientists delve into the vascular and stromal components of the TME, their contributions to epithelial–mesenchymal transition and resistance mechanisms, and emerging strategies to target these interactions for improved cancer therapy outcomes.

[Nature Reviews Nephrology] Potential therapeutic strategies for fibrotic diseases include disrupting the formation of the fibrogenic niche, inhibiting fibroblast activation, promoting fibroblast depletion, accelerating fibrosis resolution, or promoting tissue repair and regeneration.

[Cell Death Discovery] Scientists summarize the current progress in understanding the role of regulated cell death in regulated cell death (NAFLD)/Non-alcoholic steatohepatitis (NASH) and associated HCC, explore potential therapeutic strategies and clinical applications, and provide new perspectives and therapeutic targets for treating NAFLD/NASH.

[Cell Death & Disease] In 24 murine spontaneous HCC tissues, researchers observed that the proportion of myeloid-derived suppressor cells (MDSCs) plus macrophages accounts for 40–90% of tumor-infiltrating myeloid cells (TIMs) and SIRPα was highly expressed in TIMs, especially in macrophages and MDSCs.

[iScience] The authors highlights newly discovered factors involved in the dissemination of liver cancer cells and their colonization of distant organs, such as genetic mutations, metastasis-initiating cells, epithelial-mesenchymal transition, and the tumor microenvironment.

[Stem Cell Research & Therapy] Mesenchymal stem cells can treat type 1 diabetes through a variety of immune mechanisms and also play a positive role in the treatment of type 1 diabetes complications.

[Journal of Assisted Reproduction and Genetics] Scientists compare the advantages and limitations of models based on iPSCs and ESCs, with particular attention given to summarizing the results of limited studies on RNA sequencing in individual cells from human and mouse embryoid bodies.

[iScience] Scientists show that BRAF^V600E maintains aberrant DNA and histone methylation patterns in advanced colon cancer, likely preserving the transformed phenotype.