[Science Advances] Researchers screened HLA-DRB3*02:02 patients with melanoma for tumor-specific CD4 T cells and identified robust New York esophageal squamous cell carcinoma 1/HLA-DRB3*02:02 CD4 T cell activity in both peripheral blood and tumor tissue.

[Molecular Therapy] Investigators described the development of a lentiviral platform based on a novel, detargeted viral fusogen and a membrane-bound targeting moiety to enable in vivo targeted delivery of stably integrating genetic medicines without the need for lymphodepletion.

[Molecular Therapy-Methods & Clinical Development] The authors explored whether AAV mediated gene therapy can achieve durable and functional expression of human FVII in vivo.

[U of T Engineering News] Professors Craig Simmons and Julie Audet, in collaboration with boutIQ solutions Inc., a University of Toronto (U of T) spinout company specializing in AI-driven media optimization, has been awarded a $421,000 research grant through the Stem Cell Network’s 2025 Research Funding Competition.

[STEMCELL Technologies] To help scientists accelerate their workflows, STEMCELL Technologies has commercially launched the STEMprep™ Tissue Dissociator System—a new benchtop instrument that automates, standardizes, and streamlines tissue dissociation.

[Expert Review of Anticancer Therapy] The authors contextualize the emergence of ipilimumab and nivolumab in the adjuvant and neo-adjuvant treatment of resectable stage III melanoma with discussion of pivotal studies, and how they influence the current guidelines.

[Nature Communications] Scientists showed that similar tumors can arise in albino mice bearing only a Braf mutation. Incidence kinetics suggest a stochastic event underlies tumorigenesis in tumors that arise with only a Braf mutation.

[npj Viruses] The authors investigated the involvement of epidermal keratinocytes in rabies virus (RABV) entry. RABV antigen was detected in keratinocytes at inoculation sites in experimentally infected mice and at potential viral entry sites in naturally infected dogs.

[Acta Pharmacologica Sinica] Scientists evaluated TT-012 and found that most BRAF^WT melanoma lines were resistant to TT-012 due to low microphthalmia transcription factor (MITF) transcriptional activity and reduced dependency on MITF for proliferation.

[Development] Investigators established that dendritic Merkel cells express atonal homolog 1a (atoh1a), extend dynamic filopodial processes, and arise in transient waves during zebrafish skin development and regeneration.

[Developmental Cell] Researchers identified receptor-interacting serine/threonine kinase 4 (RIPK4) as an alternative upstream kinase of LATS1/2 in the Hippo pathway through screening a kinome library.

[Molecular Carcinogenesis] The expression of CDKL3 was revealed using clinical human malignant melanoma tissues and normal skin tissues.