Keep Current with the Latest in Cell Biology Research

The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

The emerging role of BMP signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature.
[International Journal of Molecular Sciences]
Ponomarev, L. C., Ksiazkiewicz, J., Staring, M. W., Luttun, A., & Zwijsen, A. (2021). The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology. International Journal of Molecular Sciences, 22(12), 6364. https://doi.org/10.3390/ijms22126364 Cite
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Multifunctional 3D-Printed Wound Dressings

Hydrogel wound dressings carrying antibacterial silver nanoparticles and vascular endothelial growth factor with predetermined release profiles were utilized to study the physiological response of the wound in a mouse model.
[ACS Nano]
Alizadehgiashi, M., Nemr, C. R., Chekini, M., Pinto Ramos, D., Mittal, N., Ahmed, S. U., Khuu, N., Kelley, S. O., & Kumacheva, E. (2021). Multifunctional 3D-Printed Wound Dressings. ACS Nano. https://doi.org/10.1021/acsnano.1c04499 Cite
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Sequential Regulation of Hemogenic Fate and Hematopoietic Stem and Progenitor Cell Formation from Arterial Endothelium by Ezh1/2

Single-cell RNA sequencing across ezh1 genotypes revealed a dropout of ezh1+/− cells among arterial endothelium associated with positive regulation of gene transcription.
[Stem Cell Reports]
Soto, R. A., Najia, M. A. T., Hachimi, M., Frame, J. M., Yette, G. A., Rocha, E. L. da, Stankunas, K., Daley, G. Q., & North, T. E. (2021). Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.05.014 Cite
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Delivery of Endothelial Cell-Laden Microgel Elicits Angiogenesis in Self-Assembling Ultrashort Peptide Hydrogels In Vitro

Scientists used a modular tissue-engineering approach, embedding SUP microgels loaded with human umbilical vein endothelial cells into a 3D SUP hydrogel containing human dermal fibroblast neonatal cells to trigger angiogenesis.
[ACS Applied Materials & Interfaces]
Ramirez-Calderon, G., Susapto, H. H., & Hauser, C. A. E. (2021). Delivery of Endothelial Cell-Laden Microgel Elicits Angiogenesis in Self-Assembling Ultrashort Peptide Hydrogels In Vitro. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.1c03787 Cite
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Molecular Tension in Syndecan-1 Is Regulated by Extracellular Mechanical Cues and Fluidic Shear Stress

Scientists examined the changes in mechanical tension of syndecan-1, a cell surface proteoglycan that is an integral part of the glycocalyx, in response to substrate stiffness and fluidic shear stress.
[Biomaterials]
Le, V., Mei, L., Voyvodic, P. L., Zhao, C., Busch, D. J., Stachowiak, J. C., & Baker, A. B. (2021). Molecular tension in syndecan-1 is regulated by extracellular mechanical cues and fluidic shear stress. Biomaterials, 275, 120947. https://doi.org/10.1016/j.biomaterials.2021.120947 Cite
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A Neutrophil-Mimetic Magnetic Nanoprobe for Molecular Magnetic Resonance Imaging of Stroke-Induced Neuroinflammatio

Inspired by the specific neutrophil–endothelium interaction, investigators designed neutrophil-camouflaged magnetic nanoprobes that can be used to target activated endothelial cells for improved neuroinflammation imaging.
[Biomaterials Science]
Tang, C., Wang, Q., Li, K., Li, X., Wang, C., Xue, L., Ju, C., & Zhang, C. (2021). A neutrophil-mimetic magnetic nanoprobe for molecular magnetic resonance imaging of stroke-induced neuroinflammation. Biomaterials Science. https://doi.org/10.1039/D1BM00566A Cite
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Epigenetic Down-Regulation of microRNA-126 in Scleroderma Endothelial Cells Is Associated with Impaired Responses to VEGF and Defective Angiogenesis

MiR-126 expression, as well as EGFL7, in SSc-MVECs and skin, was significantly down-regulated in association with increased expression of SPRED1 and PIK3R2 and diminished response to VEGF.
[Journal of Cellular and Molecular Medicine]
Wang, Y., Sun, J., & Kahaleh, B. (n.d.). Epigenetic down-regulation of microRNA-126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.16727 Cite
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Strontium–Calcium Phosphate Hybrid Cement with Enhanced Osteogenic and Angiogenic Properties for Vascularised Bone Regeneration

Sr–CPHC facilitated the migration and tube formation of human umbilical vein endothelial cells in vitro and up-regulated the expression of the vascular endothelial growth factor and Angiopoietin-1.
[Journal of Materials Chemistry B]
Wu, X., Tang, Z., Wu, K., Bai, Y., Lin, X., Yang, H., Yang, Q., Wang, Z., Ni, X., Liu, H., & Yang, L. (2021). Strontium–calcium phosphate hybrid cement with enhanced osteogenic and angiogenic properties for vascularised bone regeneration. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00439E Cite
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Not-So-Opposite Ends of the Spectrum: CD8+ T Cell Dysfunction across Chronic Infection, Cancer and Autoimmunity

A better understanding of these CD8+ T cell states may reveal novel strategies to augment clearance of chronic viral infection and cancer and to mitigate self-reactivity leading to tissue damage in autoimmunity.
[Nature Immunology]
Collier, J. L., Weiss, S. A., Pauken, K. E., Sen, D. R., & Sharpe, A. H. (2021). Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity. Nature Immunology, 1–11. https://doi.org/10.1038/s41590-021-00949-7 Cite
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Bifidobacteria-Mediated Immune System Imprinting Early in Life

Scientists showed that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life.
[Cell]
Henrick, B. M., Rodriguez, L., Lakshmikanth, T., Pou, C., Henckel, E., Arzoomand, A., Olin, A., Wang, J., Mikes, J., Tan, Z., Chen, Y., Ehrlich, A. M., Bernhardsson, A. K., Mugabo, C. H., Ambrosiani, Y., Gustafsson, A., Chew, S., Brown, H. K., Prambs, J., … Brodin, P. (2021). Bifidobacteria-mediated immune system imprinting early in life. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.05.030 Cite
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Regulatory T-Cell Phenotypes in Children with Sickle Cell Disease

The authors investigated the impact of hydroxyurea therapy on Tregs in sickle cell disease.
[Pediatric Research]
Zahran, A. M., Saad, K., Elsayh, K. I., Khalaf, S. M., Mahmoud, K. H., Elhoufey, A., & Hetta, H. F. (2021). Regulatory T-cell phenotypes in children with sickle cell disease. Pediatric Research, 1–4. https://doi.org/10.1038/s41390-021-01627-y Cite
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