[Cell Death Discovery] Investigators discuss the progress achieved in co-culturing tumor organoids with immune cells.

[Cell] Researchers showed that altered expression of the late-onset Alzheimer's disease (AD) biomarker phosphoglycerate dehydrogenase (PHGDH) modulates AD pathology in mice and human brain organoids independent of its enzymatic activity.

[Life Science Alliance] The authors evaluated hiPSC-derived respiratory organoids, which contained respiratory epithelial cells, immune cells, fibroblasts, and vascular endothelial cells, for their potential to model respiratory syncytial virus infection and support pharmaceutical research.

[Lab On A Chip] Researchers presented a versatile organ-on-a-chip platform designed to innervate organoids across diverse tissue types.

[Science Advances] The authors showed that intracellular adenosine triphosphate (ATP) regulated axoplasmic viscosity and protein aggregation in mammalian neurons.

[Science Advances] Researchers showed that during transmitter loading, synaptic vesicles substantially increased in size, which was reversible and required synaptophysin, an abundant membrane protein with an unclear function.

[Blood Cancer Journal] Investigators developed a novel humanized CD19-directed CAR-T approved for Phase I/Ib/II trials. Patients aged 3–25 years were enrolled with relapsed/refractory B-acute lymphoblastic leukemia and ineligible for allogeneic stem cell transplant.

[Science Advances] As small cell lung cancer patient-derived xenograft (PDX) models mimic therapeutic responses, scientists performed genetic screens in chemosensitive PDX models to identify drivers of chemoresistance.

[Acta Pharmacologica Sinica] Researchers investigated the modulatory effects of PD-1 blockade combined with fangchinoline on CD8⁺ T cells within the tumor microenvironment of lung cancer.

[Nature] Researchers constructed high-resolution maps of lineage states, clonal architecture, and the tumor microenvironment using spatially resolved transcriptomics from 55 samples of primary tumor and metastases collected from rapid autopsies of 13 people.

[Molecular Medicine] Investigators explored the specific roles and underlying mechanisms by which endothelial Piezo1 was involved in intestinal ischemia–reperfusion injury.

[Nature] Investigators showed that the core circadian transcription factor BMAL1 regulated circadian-dependent myocardial injury by forming a transcriptionally active heterodimer with a non-canonical partner, hypoxia-inducible factor 2 alpha (HIF2A), in a diurnal manner.