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PIM1 Accelerates Prostate Cancer Cell Motility by Phosphorylating Actin Capping Proteins

Researchers identified capping proteins CAPZA1 and CAPZB2 as PIM1 substrates, and showed that phosphorylation of either of them led to increased adhesion and migration of human prostate cancer cells.
[Cell Communication and Signaling]
Santio, N. M., Vainio, V., Hoikkala, T., Mung, K. L., Lång, M., Vahakoski, R., Zdrojewska, J., Coffey, E. T., Kremneva, E., Rainio, E.-M., & Koskinen, P. J. (2020). PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins. Cell Communication and Signaling, 18(1), 121. https://doi.org/10.1186/s12964-020-00618-6 Cite
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Proenkephalin+ Regulatory T Cells Expanded by Ultraviolet B Exposure Maintain Skin Homeostasis with a Healing Function

Scientists found that skin Treg cells possessing a healing function were expanded by UVB exposure with the expression of an endogenous opioid precursor, proenkephalin.
[Proceedings of the National Academy of Sciences of the United States of America]
Shime, H., Odanaka, M., Tsuiji, M., Matoba, T., Imai, M., Yasumizu, Y., Uraki, R., Minohara, K., Watanabe, M., Bonito, A. J., Fukuyama, H., Ohkura, N., Sakaguchi, S., Morita, A., & Yamazaki, S. (2020). Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2000372117 Cite
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CD146, from a Melanoma Cell Adhesion Molecule to a Signaling Receptor

The authors review the reports describing the newly identified ligands of CD146 and discuss the implications of these findings in establishing novel strategies for cancer therapy.
[Signal Transduction and Targeted Therapy]
Wang, Z., Xu, Q., Zhang, N., Du, X., Xu, G., & Yan, X. (2020). CD146, from a melanoma cell adhesion molecule to a signaling receptor. Signal Transduction and Targeted Therapy, 5(1), 1–15. https://doi.org/10.1038/s41392-020-00259-8 Cite
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TYME Announces Outcome of Interim Futility Review for HopES Sarcoma Phase II Study

Tyme Technologies, Inc. announced a positive outcome of an interim futility review for the HopES Sarcoma Phase II clinical trial that is evaluating TYME’s lead cancer metabolism-based candidate, SM-88, as a potential oral treatment for patients with Ewing’s Sarcoma and other high-risk sarcomas.
[Tyme Technologies, Inc. (BusinessWire, Inc.)]
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Aligned Nanofiber Scaffolds Improve Functionality of Cardiomyocytes Differentiated from Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells

Researchers focused on using Wnt inhibitors to study the differentiation of human iPSC-cardiac progenitor cells under 2D or 3D culture conditions.
[Scientific Reports]
Ding, M., Andersson, H., Martinsson, S., Sabirsh, A., Jonebring, A., Wang, Q.-D., Plowright, A. T., & Drowley, L. (2020). Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells. Scientific Reports, 10(1), 13575. https://doi.org/10.1038/s41598-020-70547-4 Cite
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Cytotoxic Effects of a Triterpene-Enriched Fraction of Cecropia Pachystachya on the Human Hormone-Refractory Prostate Cancer PC3 Cell Line

The analysis of nuclear morphology of PC3 cells treated with triterpene-enriched fraction increased the number of cells with large and regular nuclei suggesting senescence induction, which was supported by β-galactosidase overexpression.
Cytotoxic effects of a triterpene‐enriched fraction of Cecropia pachystachya on the human hormone-refractory prostate cancer PC3 cell line - ScienceDirect. (n.d.). Retrieved August 11, 2020, from https://www.sciencedirect.com/science/article/pii/S0753332220307447?via%3Dihub Cite
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Intraarticular Injection of Liposomal Adenosine Reduces Cartilage Damage in Established Murine and Rat Models of Osteoarthritis

Scientists report that injection of liposomal suspensions of either adenosine or a selective A2AR agonist, CGS21680, significantly reduced osteoarthritis (OA) cartilage damage in a murine model of obesity-induced OA.
[Scientific Reports]
Corciulo, C., Castro, C. M., Coughlin, T., Jacob, S., Li, Z., Fenyö, D., Rifkin, D. B., Kennedy, O. D., & Cronstein, B. N. (2020). Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis. Scientific Reports, 10(1), 13477. https://doi.org/10.1038/s41598-020-68302-w Cite
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Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-Human Primates

Researchers used primate pluripotent stem-cell-derived cardiomyocytes that mimicked fetal cardiomyocytes in vitro to discover hundreds of endogenous retrovirus transcripts from the primate-specific MER41 family.
[Developmental Cell]
Wilson, K. D., Ameen, M., Guo, H., Abilez, O. J., Tian, L., Mumbach, M. R., Diecke, S., Qin, X., Liu, Y., Yang, H., Ma, N., Gaddam, S., Cunningham, N. J., Gu, M., Neofytou, E., Prado, M., Hildebrandt, T. B., Karakikes, I., Chang, H. Y., & Wu, J. C. (2020). Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.07.006 Cite
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Russia’s Fast-Track Coronavirus Vaccine Draws Outrage Over Safety

Russia’s president Vladimir Putin announced that the country’s health regulator had become the world’s first to approve a coronavirus vaccine for widespread use – but scientists worldwide have condemned the decision as dangerously rushed.
[Nature News]
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Carnosine Suppresses Human Glioma Cells under Normoxic and Hypoxic Conditions Partly via Inhibiting Glutamine Metabolism

In this study, researchers investigated the effects of carnosine on human glioma U87 and U251 cell lines under normoxia and hypoxia.
[Acta Pharmacologica Sinica]
Fang, Y., Wu, M., Chen, H., Wen, T., Lyu, J., & Shen, Y. (2020). Carnosine suppresses human glioma cells under normoxic and hypoxic conditions partly via inhibiting glutamine metabolism. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-020-0488-1 Cite
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The Epigenomics of Sarcoma

Scientists review current and potential future approaches for the development of sarcoma therapies based on this emerging understanding of chromatin dysregulation.
[Nature Reviews Cancer]
Nacev, B. A., Jones, K. B., Intlekofer, A. M., Yu, J. S. E., Allis, C. D., Tap, W. D., Ladanyi, M., & Nielsen, T. O. (2020). The epigenomics of sarcoma. Nature Reviews Cancer, 1–16. https://doi.org/10.1038/s41568-020-0288-4 Cite
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