[Advanced Science] High-frequency amplification of the 17p11.2 chromosomal region in osteosarcoma represents a key molecular event driving malignant progression. Investigators focused on the key gene COPS3 in this region, delving into its molecular mechanisms regulating cancer stemness.

[Cancer Letters] Researchers demonstrated that mesenchymal glioblastoma stem cells exhibit a preferential expression and secretion of the protein LY96.

[Cell & Bioscience] Scientists elucidated the molecular mechanism by which ALYREF regulates the long non-coding RNA cancer susceptibility 19 (CASC19) through m5C modification and its impact on colorectal cancer malignancy.

[British Journal of Haematology] A truncated derivative of fibroblast growth factor receptor-1 (FGFR1) (tnFGFR1) independently transforms haematopoietic stem cells, leading to a stem cell-like leukaemia/lymphoma syndrome.

[Journal of Translational Medicine] The authors provide a comprehensive characterization of the neuropilin-1–IL-6–STAT3 axis as a fundamental driver of bladder cancer stemness.

[Journal of Translational Medicine] Researchers showed that eugenoplatin, a novel DNA-damaging agent that can also target cancer stem cells, could be of great therapeutic value for triple-negative breast cancer patients.

[Cancer Biology & Medicine] Scientists elucidated the influence of BEX2 on colorectal cancer (CRC) stemness and the interaction with the Hh signaling pathway, potentially uncovering innovative therapeutic strategies for combating CRC.

[Journal of Neuro-Oncology] Mouse glioma cells and human patient–derived glioma stem cells were treated with pan-Akt inhibitor or β-catenin inhibitor to evaluate effects on cell viability, apoptosis, β-catenin transcriptional activity, and Wnt gene and protein expression.

[The Prostate] Identifying downstream calcitonin-regulated genes may provide clinically useful biomarkers. Immunohistochemistry was performed to assess zinc finger protein-like 1 localization with neuroendocrine and stem cell markers.

[Biochemical and Biophysical Research Communications] The authors systematically evaluate the literature to functionally define a distinct class of cancer stemness-modulating circRNAs in colorectal cancer.

[Can-Fite BioPharma, Ltd. (Globe Newswire)] Can-Fite BioPharma, Ltd. announced results from its Phase IIa open-label study evaluating namodenoson in patients with advanced pancreatic ductal adenocarcinoma who had progressed following prior systemic therapies.

[International Journal of Oral Science] Scientists revealed that loss of Gli3 alone in dental mesenchymal root progenitor cells caused shortened roots and that concurrent loss of Gli2 and Gli3 exacerbated root malformations, concomitant with profound impairments in cell proliferation and multilineage differentiation.