Keep Current with the Latest in Cell Biology Research
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Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis
[Cancer Research] Researchers demonstrated that age engenders the development of an immunosuppressive tumor microenvironment, which is linked to phenotypes associated with melanoma metastasis.
Skin Health and Biological Aging
[Nature Aging] Researchers provide a review of the interactions between skin exposure, aging hallmarks in the skin, and associated systemic changes, and their implications in treatment and disease.
Alpha-Synuclein Modulates the Positioning of Endolysosomes in Melanoma Cells
[Human Molecular Genetics] Scientists showed that SK-MEL-28 SNCA-knockout cells relative to control cells exhibit an (i) increased density of endolysosomes; (ii) increased perinuclear positioning of large endolysosomes; and (iii) decreased levels of the tetraspanins CD9 and CD81.
Inflammatory Oriented Nanospheres-Reconstructed Extracellular Matrix in Ischemic Stroke
[ACS Nano] Researchers proposed a strategy to prevent secondary brain injury and complications by modulating immunity and ECM remodeling.
Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment
[Cancer Research] Scientists delve into the vascular and stromal components of the TME, their contributions to epithelial–mesenchymal transition and resistance mechanisms, and emerging strategies to target these interactions for improved cancer therapy outcomes.
Fibroblast Activation and Heterogeneity in Fibrotic Disease
[Nature Reviews Nephrology] Potential therapeutic strategies for fibrotic diseases include disrupting the formation of the fibrogenic niche, inhibiting fibroblast activation, promoting fibroblast depletion, accelerating fibrosis resolution, or promoting tissue repair and regeneration.
Killing Hepatocellular Carcinoma in the NAFLD/NASH Stage: A Comprehensive Perspective on Targeting Regulated Cell Death
[Cell Death Discovery] Scientists summarize the current progress in understanding the role of regulated cell death in regulated cell death (NAFLD)/Non-alcoholic steatohepatitis (NASH) and associated HCC, explore potential therapeutic strategies and clinical applications, and provide new perspectives and therapeutic targets for treating NAFLD/NASH.
SIRPα Blockade Therapy Potentiates Immunotherapy by Inhibiting PD-L1+ Myeloid Cells in Hepatocellular Carcinoma
[Cell Death & Disease] In 24 murine spontaneous HCC tissues, researchers observed that the proportion of myeloid-derived suppressor cells (MDSCs) plus macrophages accounts for 40–90% of tumor-infiltrating myeloid cells (TIMs) and SIRPα was highly expressed in TIMs, especially in macrophages and MDSCs.
Metastatic Hepatic Carcinoma: Mechanisms, Emerging Therapeutics, and Future Perspectives
[iScience] The authors highlights newly discovered factors involved in the dissemination of liver cancer cells and their colonization of distant organs, such as genetic mutations, metastasis-initiating cells, epithelial-mesenchymal transition, and the tumor microenvironment.
The Role and Mechanism of Mesenchymal Stem Cells in Immunomodulation of Type 1 Diabetes Mellitus and Its Complications: Recent Research Progress and Challenges: A...
[Stem Cell Research & Therapy] Mesenchymal stem cells can treat type 1 diabetes through a variety of immune mechanisms and also play a positive role in the treatment of type 1 diabetes complications.
Embryoid Bodies As a Model System for Exploring Early Human Embryonic Development
[Journal of Assisted Reproduction and Genetics] Scientists compare the advantages and limitations of models based on iPSCs and ESCs, with particular attention given to summarizing the results of limited studies on RNA sequencing in individual cells from human and mouse embryoid bodies.
BRAFV600E Maintains the CpG Island Methylator Phenotype and DNA Methylation of PRC2 Target Genes in Colon Cancer
[iScience] Scientists show that BRAFV600E maintains aberrant DNA and histone methylation patterns in advanced colon cancer, likely preserving the transformed phenotype.