Keep Current with the Latest in Cell Biology Research

Hematopoietic Stem Cell Transplantation Outcomes for High-Risk AML: A Report From the Children’s Oncology Group

[Journal of Clinical Oncology] Researchers conducted a cross-study analysis to determine whether HSC transplantation improves the outcomes of patients with contemporarily defined high-risk AML.

Venetoclax Plus Modified-Intensity Idarubicin and Cytarabine Treatment As First-Line Treatment for Newly Diagnosed Pediatric Acute Myeloid Leukemia

[Clinical Cancer Research] In an open-label, single-arm, multi-center prospective clinical trial, 65 newly diagnosed AML pediatric patients received venetoclax and modified-intensity cytarabine and idarubicin.

Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors

[Cancer Research] Researchers investigated the role of nitrosylation, a nitric oxide-induced post-translational modification, in melanoma progression and therapeutic resistance.

The Chemical Chaperone 4-Phenylbutyric Acid Rescues Molecular Cell Defects of COL3A1 Mutations That Cause Vascular Ehlers Danlos Syndrome

[Cell Death Discovery] Analysis of two novel COL3A1 glycine mutations, G189S and G906R, in primary patient fibroblast cultures revealed secretion of misfolded collagen III and intracellular collagen retention leading to lower extracellular collagen levels.

Rechallenge of Ipilimumab and Nivolumab in Advanced Melanoma Patients after Previous Ipilimumab-Based Therapy

[British Journal of Cancer] Data from advanced melanoma patients rechallenged with ipilimumab+nivolumab after previous ipilimumab-containing treatment were retrieved from the nationwide Dutch Melanoma Treatment Registry.

Stromal Lipid Species Dictate Melanoma Metastasis and Tropism

[Cancer Cell] Researchers showed that abundant stromal lipids from young subcutaneous adipocytes, including phosphatidylcholines, are taken up by melanoma cells, where they upregulate melanoma PI3K-AKT signaling, fatty acid oxidation, oxidative phosphorylation leading to oxidative stress, resulting in decreased metastatic burden.

Insights into Modeling Inflammatory Bowel Disease from Stem Cell Derived Intestinal Organoids

[Stem Cell Reviews and Reports] The authors consolidate current knowledge on inflammatory bowel disease pathogenesis and treatments, emphasizing the pivotal potential of human intestinal organoids as a robust platform for mechanistic studies and treatment exploration.

Diminution of HSP75 Disrupts Intestinal Epithelial Barrier by Inciting mPTP Opening in Ulcerative Colitis

[Cellular Signalling] Scientists ascertained that HSP75 was significantly diminished in the intestinal mucosa of ulcerative colitis patients and experimental colitis mice, concomitantly with the disruption of the intestinal epithelial barrier.

Vitamin D Enhances the Therapeutic Effect of TNF-α Antibodies through Lipid Metabolism in Overweight IBD Patients

[Cellular and Molecular Life Sciences] Investigators revealed that overweight inflammatory bowel disease patients present decreased vitamin D levels in the intestinal epithelium alongside elevated TNF-α levels.

β-Glucuronidase-Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity through Depleting the Regenerative Epithelial Stem/Progenitor Pool

[Advanced Science] Researchers explored the crosstalk between gut microbiota and intestinal stem cells in intestinal mucositis triggered by irinotecan chemotherapy.

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

[Advanced Science] Scientists revealed that the voltage-gated calcium channel subunit α2δ1-mediated calcium signaling can upregulate the expression of SIRT4, which is highly expressed in α2δ1-positive pancreatic tumor-initiating cells.

A Novel Model of Glioblastoma Recurrence to Identify Therapeutic Vulnerabilities

[EMBO Molecular Medicine] Researchers designed and characterized a novel induced-recurrence model in which mice xenografted with primary patient-derived glioma initiating/stem cells are treated with a therapeutic regimen closely recapitulating patient standard of care, followed by monitoring until tumours recur.

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