Keep Current with the Latest in Cell Biology Research

SDF-1α Gene-Activated Collagen Scaffold Drives Functional Differentiation of Human Schwann Cells for Wound Healing Applications

Researchers explored the role of a collagen‐chondroitin sulfate scaffold functionalized with a pro‐angiogenic gene stromal‐derived factor‐1 alpha (SDF‐1α) – an SDF‐1α gene‐activated scaffold on the functional regulation of human Schwann cells.
[Biotechnology and Bioengineering]
Laiva, A. L., O’Brien, F. J., & Keogh, M. B. (n.d.). SDF-1α gene-activated collagen scaffold drives functional differentiation of human Schwann cells for wound healing applications. Biotechnology and Bioengineering, n/a(n/a). https://doi.org/10.1002/bit.27601 Cite
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The Histone H2B Ubiquitin Ligase RNF40 Is Required for HER2-Driven Mammary Tumorigenesis

Scientists utilized human tumor samples, cell culture models, and a mammary carcinoma mouse model with tissue-specific Rnf40 deletion and identified an unexpected tumor-supportive role of RNF40 in HER2-positive breast cancer subtype.
[Cell Death & Disease]
Wegwitz, F., Prokakis, E., Pejkovska, A., Kosinsky, R. L., Glatzel, M., Pantel, K., Wikman, H., & Johnsen, S. A. (2020). The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03081-w Cite
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Anti-GD2-IRDye800CW as a Targeted Probe for Fluorescence-Guided Surgery in Neuroblastoma

Scientists demonstrated specific binding of anti-GD2-IRDye800CW to human neuroblastoma cells in vitro and in vivo using xenograft mouse models.
[Scientific Reports]
Wellens, L. M., Deken, M. M., Sier, C. F. M., Johnson, H. R., de la Jara Ortiz, F., Bhairosingh, S. S., Houvast, R. D., Kholosy, W. M., Baart, V. M., Pieters, A. M. M. J., de Krijger, R. R., Molenaar, J. J., Wehrens, E. J., Dekkers, J. F., Wijnen, M. H. W. A., Vahrmeijer, A. L., & Rios, A. C. (2020). Anti-GD2-IRDye800CW as a targeted probe for fluorescence-guided surgery in neuroblastoma. Scientific Reports, 10(1), 17667. https://doi.org/10.1038/s41598-020-74464-4 Cite
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Identification of Oncolytic Vaccinia Restriction Factors in Canine High-Grade Mammary Tumor Cells Using Single-Cell Transcriptomics

Single-cell RNA-seq performed on two different TNBC cell samples, infected or not with vaccinia virus, highlighted three distinct populations: naïve cells, bystander cells, defined as cells exposed to the virus but not infected and infected cells.
[PLoS Pathogens]
Cambien, B., Lebrigand, K., Baeri, A., Nottet, N., Compin, C., Lamit, A., Ferraris, O., Peyrefitte, C. N., Magnone, V., Henriques, J., Zaragosi, L.-E., Giorgetti-Peraldi, S., Bost, F., Gautier-Isola, M., Rezzonico, R., Barbry, P., Barthel, R., Mari, B., & Vassaux, G. (2020). Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics. PLOS Pathogens, 16(10), e1008660. https://doi.org/10.1371/journal.ppat.1008660 Cite
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Novel Carbon Film Induces Precocious Calcium Oscillation to Promote Neuronal Cell Maturation

Investigators tested the capacity of a carbon material composed of amorphous sp3 carbon backbone, embedded with a percolating network of sp2 carbon domains to sustain neuronal cultures. They found that cortical neurons survive and develop faster on this novel carbon material.
[Scientific Reports]
Ludwig, A., Kesaf, S., Heikkinen, J. J., Sukhanova, T., Khakipoor, S., Molinari, F., Pellegrino, C., Kim, S. I., Han, J. G., Huttunen, H. J., Lauri, S. E., Franssila, S., Jokinen, V., & Rivera, C. (2020). Novel carbon film induces precocious calcium oscillation to promote neuronal cell maturation. Scientific Reports, 10(1), 17661. https://doi.org/10.1038/s41598-020-74535-6 Cite
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Endothelial, Pericyte and Tumor Cell Expression in Glioblastoma Identifies Fibroblast Activation Protein (FAP) as an Excellent Target for Immunotherapy

Short‐term cultures of glioma neural stem cells were compared to cultures of healthy astrocytes and neurons using flow cytometry. Glioblastoma tissues were dissociated and analysed by high‐parameter flow cytometry and single‐cell transcriptomics.
[Clinical & Translational Immunology]
Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy - Ebert - 2020 - Clinical & Translational Immunology - Wiley Online Library. (n.d.). Retrieved October 19, 2020, from https://onlinelibrary.wiley.com/doi/10.1002/cti2.1191 Cite
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Orion Biotechnology Successfully Completes Phase I Clinical Trial of a First-in-Class Precision Engineered Ligand Analog for HIV Prevention

Orion Biotechnology Canada Ltd. announced the results of their Phase I study of OB-002H which is an investigational candidate microbicide for HIV prevention.
[Orion Biotechnology Canada Ltd.]
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Anti-GD2-IRDye800CW as a Targeted Probe for Fluorescence-Guided Surgery in Neuroblastoma

Scientists implemented a xenograft model of patient-derived neuroblastoma organoids with differential GD2 expression and showed that even low GD2 expressing tumors still provided an adequate real-time fluorescence signal.
[Scientific Reports]
Wellens, L. M., Deken, M. M., Sier, C. F. M., Johnson, H. R., de la Jara Ortiz, F., Bhairosingh, S. S., Houvast, R. D., Kholosy, W. M., Baart, V. M., Pieters, A. M. M. J., de Krijger, R. R., Molenaar, J. J., Wehrens, E. J., Dekkers, J. F., Wijnen, M. H. W. A., Vahrmeijer, A. L., & Rios, A. C. (2020). Anti-GD2-IRDye800CW as a targeted probe for fluorescence-guided surgery in neuroblastoma. Scientific Reports, 10(1), 17667. https://doi.org/10.1038/s41598-020-74464-4 Cite
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Donor-Derived CD19 CAR-T Cell Therapy of Relapse of CD19-Positive B-ALL Post Allotransplant

Forty-three subjects with B-cell acute lymphoblastic leukemia relapsing post allotransplant received CAR-T cells were analyzed.
[Leukemia]
Zhang, C., Wang, X.-Q., Zhang, R.-L., Liu, F., Wang, Y., Yan, Z.-L., Song, Y.-P., Yang, T., Li, P., Wang, Z., Ma, Y.-Y., Gao, L., Liu, Y., Gao, L., Kong, P.-Y., Liu, J., Tan, X., Zhong, J. F., Chen, Y.-Q., … Zhang, X. (2020). Donor-derived CD19 CAR-T cell therapy of relapse of CD19-positive B-ALL post allotransplant. Leukemia, 1–8. https://doi.org/10.1038/s41375-020-01056-6 Cite
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Multiscale Fluorescent Tracking of Immune Cells in the Liver with a Highly Biocompatible Far-Red Emitting Polymer Probe

A newly-designed water-soluble far-red emitting polymer probe, 19K-6H, with a large Stokes shift, was thus evaluated for the tracking of primary immune CD8 T cells. 19K-6H-labelled primary CD8 T cells were injected to mice in a classical model of immune mediated hepatitis.
[Scientific Reports]
Multiscale fluorescent tracking of immune cells in the liver with a highly biocompatible far-red emitting polymer probe | Scientific Reports. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41598-020-74621-9 Cite
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First Patient Dosed in Phase II Trial to Treat Complications in COVID-19

Arch Biopartners, Inc. announced it has dosed the first patient in the Phase II trial of its lead drug LSALT peptide, targeting prevention of acute lung injury, acute kidney injury and other complications caused by inflammation in hospitalized patients with moderate to severe cases of COVID-19.
[Arch Biopartners, Inc.]
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