[Microsystems & Nanoengineering] The authors highlights advanced engineering strategies for in vitro vascular microsystems, covering the domains related to rational designs, manufacturing approaches, supporting materials, and organ-specific cell types.

[Nature] New technologies to shuttle drugs into the brain are showing promise in Alzheimer’s disease, cancer, and more.

[Science Advances] In Rab27a/b double knock outmice, the brain vasculature is abnormally scarce, while the blood vessels become dysmorphic and hyperpermeable in the context of brain tumors, including syngeneic glioblastoma.

[Stem Cells] Scientists deleted the whole genomic region of the m⁶A reader YTHDF2 and discovered that YTHDF2 is dispensable for the maintenance, but important for the differentiation of hESCs, especially for the differentiation towards ectoderm.

[Nature Communications] Researchers identified the p53-induced long non-coding RNA LOC644656 as a key regulator of genotoxic stress-induced stem cell maldifferentiation in hESCs.

[Cell Death Discovery] Scientists investigated the effects of shaking cultures on the circadian rhythm of key clock genes in iPSC-embryoid bodies.

[Current Opinion In Genetics & Development] The authors review how embryo and placenta models built from naïve stem cells can be leveraged to obtain mechanistic insights into human implantation and trophoblast invasion.

[Cell Stem Cell] Investigators reported that a knockout of m⁶A writers or overexpression of m⁶A erasers leads to an increased percentage of human primordial germ-like cells induced from ESCs using a 3D aggregate system.

[UniXell Biotech (BioSpace)] Shanghai UniXell Biotechnology Co., Ltd. (UniXell Biotech) announced the successful first administration of its proprietary Parkinson's disease cell drug UX-DA001 in China.

[Applied StemCell] Applied StemCell announced the launch of their first hypoimmunogenic hiPSC products which are designed to empower researchers developing next-generation allogeneic cell therapies.

[Cellino (BioSpace)] Cellino announced that its optical biomanufacturing technology for generating iPSCs has received the FDA’s AMT designation from the Center for Biologics Evaluation and Research.

[Advanced Healthcare Materials] Scientists employed synthetic, matrix metalloproteinase-degradable polyethylene glycol-based hydrogels to define the effect of mechanical and biochemical cues on cardioid development.