[iScience] Investigators used an cell model of sepsis in vitro to isolate endothelial progenitor cells for better observation.

[eLife] Arpin depletion in human umbilical vein endothelial cells caused the formation of actomyosin stress fibers leading to increased permeability in an Arp2/3-independent manner.

[Clinical Rheumatology] Rheumatoid arthritis-derived fibroblast-like synoviocytes were seeded on type I collagen gel, and human umbilical vein endothelial cells were directly added.

[Science] Researchers investigated germline mutations in GNAI2, which encodes Gαi2, a key component in heterotrimeric G protein signal transduction usually thought to regulate adenylyl cyclase–mediated cyclic adenosine monophosphate production.

[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that ectopic expression of the viral IE1 protein, a target of Pentamer-mediated transcriptional repression, complemented the growth defect of a Pentamer-positive virus.

[Science Advances] The authors reported a series of miRNA-based Lin28A-miRNA proteolysis-targeting chimeras designed to efficiently degrade Lin28A through a ubiquitin-proteasome–dependent mechanism, resulting in up-regulation of mature let-7 family.

[Science Advances] Investigators reported that long-chain acyl-CoA synthase 6 (ACSL6) was highly expressed in liver cancer and correlated with poor prognosis.

[Science Translational Medicine] Using high-dose-rate brachytherapy, the authors treated mice bearing syngeneic tumors with a single fraction of heterogeneous radiation therapy at a dose ranging from 2 to 30 gray.

[Cancer Immunology Research] Investigators explore the current knowledge on how neutrophils in the gut fluctuate between an inflammatory or immunosuppressive state and how they contribute to tumor development.

[UT Southwestern Medical Center] Dr. Zhijian Chen, Professor of Molecular Biology and Director of the Center for Inflammation Research at UT Southwestern Medical Center, has been awarded the Albert Lasker Basic Medical Research Award for his discovery of the cGAS enzyme, which senses invading pathogens and triggers the body’s innate immune system.

[UChicago Medicine] A University of Chicago Medicine patient became the first in the world to receive the drug guselkumab since its approval by the FDA for treating moderate to severe ulcerative colitis.

[Alamos Gold, Inc.] Alamos Gold, Inc. announced a significant contribution to The Princess Margaret Cancer Foundation to create the new Alamos Gold Chair in Gastrointestinal Surgical Oncology. The $2 million contribution over ten years will support the new Chair in making an impact on cancer research aimed at better understanding, diagnosing, and treating gastrointestinal cancers.