Keep Current with the Latest in Cell Biology Research

FDA Investigating Serious Risk of T-cell Malignancy Following BCMA-Directed or CD19-Directed Autologous Chimeric Antigen Receptor (CAR) T Cell Immunotherapies

[FDA] The FDA has received reports of T cell malignancies, including chimeric antigen receptor CAR-positive lymphoma, in patients who received treatment with BCMA- or CD19-directed autologous CAR T cell immunotherapies.

Modular Chimeric Cytokine Receptors with Leucine Zippers Enhance the Antitumour Activity of CAR T Cells via JAK/STAT Signaling

[Nature Biomedical Engineering] Investigators showed that replacement of the extracellular domains of heterodimeric cytokine receptors in T cells with two leucine zipper motifs provided optimal Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling.

CAR+ T Cell Lymphoma Post Ciltacabtagene Autoleucel Therapy for Relapsed Refractory Multiple Myeloma

[blood] The authors presented the clinicogenomic characterization of a CARTITUDE-4 patient who developed a CAR+ T cell lymphoma post cilta-cel. Diagnostic and staging workup included biopsy analyses and FDG-PET scan.

Phase I Clinical Trial of Intracerebroventricular Transplantation of Allogeneic Neural Stem Cells in People with Progressive Multiple Sclerosis

[Cell Stem Cell] Scientists reported the analysis of one year of data from the first cohort of 15 patients enrolled in an open-label, first-in-human, dose-escalation Phase I study to determine the feasibility, safety, and tolerability of the transplantation of allogeneic human neural stem/progenitor cells for the treatment of secondary progressive multiple sclerosis.

EpCAM-Targeting CAR-T Cell Immunotherapy Is Safe and Efficacious for Epithelial Tumors

[Science Advances] Researchers demonstrated that EpCAM–CAR-T cells costimulated by Dectin-1 exhibited robust antitumor activity without adverse effects in xenograft mouse models and EpCAM-humanized mice.

Genetically Engineered Transfusable Platelets Using mRNA Lipid Nanoparticles

[Science Advances] Scientists described an approach using platelet-optimized lipid nanoparticles containing mRNA to enable exogenous protein expression in human and rat platelets.

Clonal Hematopoiesis with DNMT3A and PPM1D Mutations Impairs Regeneration in Autologous Stem Cell Transplant Recipients

[Haematologica] Investigators performed targeted DNA sequencing of 457 hematopoietic stem cell grafts collected for autologous stem cell transplantation in myeloma patients and correlated their findings with high-dimensional longitudinal clinical and laboratory data.

Generation of a C57BL/6J Mouse Strain Expressing the CD45.1 Epitope to Improve Hematopoietic Stem Cell Engraftment and Adoptive Cell Transfer Experiments

[Lab Animal] Researchers identified cathepsin E (Ctse) as the most differentially expressed gene between CD8+ T cells of B6 and B6.SJL and demonstrated that the differences reported between these two mouse strains were not due to CTSE.

IL-21-Armored B7H3 CAR-iNKT Cells Exert Potent Antitumor Effects

[iScience] Investigators demonstrated that invariant NKT (iNKT) cells could be efficiently expanded using modified cytokines combination from peripheral blood mononuclear cells.

Surface Modification of Lipid Nanoparticles for Gene Therapy

[The Journal of Gene Medicine] The authors provide an overview of current preclinical approaches in that lipid nanoparticle surface modification was leveraged for cell and tissue targeting by conjugating aptamers, antibodies, and peptides among others.

Dynamic Regulatory Elements in Single-Cell Multimodal Data Implicate Key Immune Cell States Enriched for Autoimmune Disease Heritability

[Nature Genetics] To identify noncoding regions with accessible chromatin that associate with cell-state-defining gene expression patterns, researchers leveraged multimodal single-nucleus RNA and assay for transposase-accessible chromatin sequencing data across 28,674 cells from the inflamed synovial tissue of 12 donors.

Cellular Development and Evolution of the Mammalian Cerebellum

[Nature] The authors generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in human, mouse, and the marsupial opossum.

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