[Analytical Chemistry] Researchers presented a novel workflow to enable interlaboratory studies, comprising live-cell imaging and single-cell isolation, followed by freeze-drying, international shipping, reconstitution, and untargeted lipidomics analysis.

[New England Journal of Medicine] In this Phase III, double-blind, placebo-controlled trial, we randomly assigned participants in a 1:1:1:1 ratio to receive orforglipron at one of three doses or placebo once daily for 40 weeks.

[New England Journal of Medicine] Investigators conducted a Phase I–II study of zimislecel in persons with type 1 diabetes. In part A, participants received a half dose of zimislecel as a single infusion into the portal vein, with an option for a second half dose within two years. In parts B and C, participants received a full dose of zimislecel as a single infusion.

[Cell Reports] Scientists summarize the updated understanding of glucose metabolism in mature β and stem cell-derived β (SC-β) cells, highlighting a potential metabolic defect underlying SC-β immaturity.

[Amplia Therapeutics] Amplia has received US ethics approval to initiate a Phase II clinical trial of narmafotinib in combination with FOLFIRINOX chemotherapy for advanced pancreatic cancer patients.

The Trump administration has dealt a sharp blow to work on H.I.V. vaccines, terminating a $258 million program whose work was instrumental to the...

[Signal Transduction and Targeted Therapy] Scientists highlighted the importance of natural killer cell heterogeneity and TSC22D3 in immune-mediated hypersensitivity disorders, offering potential therapeutic targets for severe cutaneous adverse drug reactions and related conditions.

[ACS nano] Researchers developed a calcium phosphate (CaP)-covered nanovaccine (NV) based on hepatitis B core antigen derived virus-like particles (HBc VLPs), optimized for mucosal delivery applications.

[ACS Nano] This gelatin microcarrier-based vaccine, combined with localized alternating magnetic field-induced hyperthermia, effectively promotes dendritic cell recruitment, enhances immune responses, and effectively inhibits tumor growth.

[Environment International] Researchers characterized the effect of triclosan on cytokine responses of peripheral blood mononuclear cells.

[Cancer Research] Investigators integrated single-cell RNA-sequencing and T cell receptor-sequencing to comprehensively characterize the tumor immune microenvironment (TIME) of head and neck squamous cell carcinoma biopsies prior to a Phase II neoadjuvant immunotherapy clinical trial.

[Advanced Healthcare Materials] Scientists presented a promising strategy for efficient cancer therapy by utilizing ultrasound-regulated nanodrug-hitchhiking macrophages.