[HepaRegeniX] HepaRegeniX announced that the first patient undergoing major liver resection due to liver metastases originating from colorectal cancer has completed the 28 day treatment with darizmetinib (formerly HRX215) in the second pilot part of its ongoing Phase 1b/2a study.

[TriSalus Life Sciences, Inc.] TriSalus Life Sciences, Inc. announced it has received US FDA 510(k) clearance for TriNav® Advance, the newest addition to its Pressure-Enabled Drug Delivery™ (PEDD) portfolio.

[Nature] Investigators showed that exogenous serine-dependent pancreatic ductal adenocarcinoma cells reprogram neighbouring hepatocytes through a CXCL5–CXCR2 axis.

[Journal of Hepatology] Scientists aimed to investigate the systemic factors and cellular mechanisms that promote aged liver regeneration, highlighting the therapeutic potential of lymphotoxin β-based strategies to increase regeneration in aging populations.

[Gut] Researchers investigated whether butyrylcholinesterase (BuChE) regulates fibrosis by modulating acetylcholine bioavailability and identified downstream cholinergic signalling, observing increased hepatic stellate cell activation and fibrosis upon hepatocyte BuChE deletion or inhibition.

[Nature Biomedical Engineering] Investigators showed that in hepatitis B virus (HBV) mouse models, a single dose of CRMA-1001, which employs an optimized epigenetic silencer that represses viral transcription, produced >3-log10 reductions in viral biomarkers, which correlated with de novo methylation of HBV DNA.

[Cell Death & Disease] The authors found that copper-provoked iron vulnerability is not driven by Fenton chemistry-driven ROS damage, but instead induces a cuproptotic-like mechanism, characterized by proteotoxic stress, loss of iron-sulfur cluster enzyme activity, and severe mitochondrial dysfunction in hereditary hemochromatosis.

[EMBO Reports] Scientists identified VGLL4 as a positive regulator of metabolic dysfunction-associated fatty liver disease progression.

[Cellular and Molecular Gastroenterology and Hepatology] Researchers investigated the dual reaction pattern for interactions of Notch signaling with Alk1 and Gata4 pathways, wherein unbalanced Notch signaling in liver sinusoidal endothelial cells leads either to vascular malformations or MASH-like liver fibrosis.

[Ecotoxicology and Environmental Safety] Researchers designed a study to systematically evaluate and clarify the protective effects and mechanisms of Schisandrin B against microcystin-LR-induced hepatotoxicity.

[Ecotoxicology and Environmental Safety] The authors investigated the role of circadian regulation in chronic noise-induced hepatic lipid metabolic alterations using transcriptomic, metabolomic, and genetic approaches.

[Toxicological Sciences] Investigators aimed to delineate the spatial, cellular, and epigenetic determinants of cytochrome P450 2E1 expression in health and in alcohol-related liver disease. They integrated cross-species immunohistochemistry with bulk RNA sequencing, single-cell RNA sequencing, and paired single-nucleus RNA and ATAC sequencing.