Keep Current with the Latest in Cell Biology Research

Engineering In Vitro Vascular Microsystems

[Microsystems & Nanoengineering] The authors highlights advanced engineering strategies for in vitro vascular microsystems, covering the domains related to rational designs, manufacturing approaches, supporting materials, and organ-specific cell types.

Brain Drugs Can Now Cross the Once Impenetrable Blood-Brain Barrier

[Nature] New technologies to shuttle drugs into the brain are showing promise in Alzheimer’s disease, cancer, and more.

Immune Cell Infiltration into Brain Tumor Microenvironment Is Mediated by Rab27-Regulated Vascular Wall Integrity

[Science Advances] In Rab27a/b double knock outmice, the brain vasculature is abnormally scarce, while the blood vessels become dysmorphic and hyperpermeable in the context of brain tumors, including syngeneic glioblastoma.

Transcriptomic Analysis of the m6A Reader YTHDF2 in the Maintenance and Differentiation of Human Embryonic Stem Cells

[Stem Cells] Scientists deleted the whole genomic region of the m6A reader YTHDF2 and discovered that YTHDF2 is dispensable for the maintenance, but important for the differentiation of hESCs, especially for the differentiation towards ectoderm.

p53-Inducible lncRNA LOC644656 Causes Genotoxic Stress-Induced Stem Cell Maldifferentiation and Cancer Chemoresistance

[Nature Communications] Researchers identified the p53-induced long non-coding RNA LOC644656 as a key regulator of genotoxic stress-induced stem cell maldifferentiation in hESCs.

Shaking Culture Attenuates Circadian Rhythms in Induced Pluripotent Stem Cells during Osteogenic Differentiation through the TEAD-Fbxl3-CRY Axis

[Cell Death Discovery] Scientists investigated the effects of shaking cultures on the circadian rhythm of key clock genes in iPSC-embryoid bodies.

Stem Cell Models of Human Embryo Implantation and Trophoblast Invasion

[Current Opinion In Genetics & Development] The authors review how embryo and placenta models built from naïve stem cells can be leveraged to obtain mechanistic insights into human implantation and trophoblast invasion.

IGF2BP1 Restricts the Induction of Human Primordial Germ Cell Fate in an M6a-Dependent Manner

[Cell Stem Cell] Investigators reported that a knockout of m6A writers or overexpression of m6A erasers leads to an increased percentage of human primordial germ-like cells induced from ESCs using a 3D aggregate system.

UniXell Biotechnology Announces the First Patient Dosed with UX-DA001, an Investigational Autologous iPSC Based Cell Therapy for the Treatment of Parkinson’s Disease, in Its...

[UniXell Biotech (BioSpace)] Shanghai UniXell Biotechnology Co., Ltd. (UniXell Biotech) announced the successful first administration of its proprietary Parkinson's disease cell drug UX-DA001 in China.

Applied StemCell Launches Two New Hypoimmunogenic hiPSC Products to Accelerate Allogeneic Cell Therapy Development

[Applied StemCell] Applied StemCell announced the launch of their first hypoimmunogenic hiPSC products which are designed to empower researchers developing next-generation allogeneic cell therapies.

Cellino’s iPSC Manufacturing Technology Receives FDA Advanced Manufacturing Technology (AMT) Designation

[Cellino (BioSpace)] Cellino announced that its optical biomanufacturing technology for generating iPSCs has received the FDA’s AMT designation from the Center for Biologics Evaluation and Research.

Mechanically and Chemically Defined PEG Hydrogels Improve Reproducibility in Human Cardioid Development

[Advanced Healthcare Materials] Scientists employed synthetic, matrix metalloproteinase-degradable polyethylene glycol-based hydrogels to define the effect of mechanical and biochemical cues on cardioid development.

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