[Journal of Clinical Oncology] Researchers conducted a cross-study analysis to determine whether HSC transplantation improves the outcomes of patients with contemporarily defined high-risk AML.

[Clinical Cancer Research] In an open-label, single-arm, multi-center prospective clinical trial, 65 newly diagnosed AML pediatric patients received venetoclax and modified-intensity cytarabine and idarubicin.

[Cancer Research] Researchers investigated the role of nitrosylation, a nitric oxide-induced post-translational modification, in melanoma progression and therapeutic resistance.

[Cell Death Discovery] Analysis of two novel COL3A1 glycine mutations, G189S and G906R, in primary patient fibroblast cultures revealed secretion of misfolded collagen III and intracellular collagen retention leading to lower extracellular collagen levels.

[British Journal of Cancer] Data from advanced melanoma patients rechallenged with ipilimumab+nivolumab after previous ipilimumab-containing treatment were retrieved from the nationwide Dutch Melanoma Treatment Registry.

[Cancer Cell] Researchers showed that abundant stromal lipids from young subcutaneous adipocytes, including phosphatidylcholines, are taken up by melanoma cells, where they upregulate melanoma PI3K-AKT signaling, fatty acid oxidation, oxidative phosphorylation leading to oxidative stress, resulting in decreased metastatic burden.

[Stem Cell Reviews and Reports] The authors consolidate current knowledge on inflammatory bowel disease pathogenesis and treatments, emphasizing the pivotal potential of human intestinal organoids as a robust platform for mechanistic studies and treatment exploration.

[Cellular Signalling] Scientists ascertained that HSP75 was significantly diminished in the intestinal mucosa of ulcerative colitis patients and experimental colitis mice, concomitantly with the disruption of the intestinal epithelial barrier.

[Cellular and Molecular Life Sciences] Investigators revealed that overweight inflammatory bowel disease patients present decreased vitamin D levels in the intestinal epithelium alongside elevated TNF-α levels.

[Advanced Science] Researchers explored the crosstalk between gut microbiota and intestinal stem cells in intestinal mucositis triggered by irinotecan chemotherapy.

[Advanced Science] Scientists revealed that the voltage-gated calcium channel subunit α2δ1-mediated calcium signaling can upregulate the expression of SIRT4, which is highly expressed in α2δ1-positive pancreatic tumor-initiating cells.

[EMBO Molecular Medicine] Researchers designed and characterized a novel induced-recurrence model in which mice xenografted with primary patient-derived glioma initiating/stem cells are treated with a therapeutic regimen closely recapitulating patient standard of care, followed by monitoring until tumours recur.