[Science Translational Medicine] Scientists showed that ubiquitin-proteasome system disruption in alveolar type 2 epithelial cells amplifies profibrotic signaling to macrophages through macrophage migration inhibitory factor family proteins in several models.

[Molecular Therapy] Researchers identified circPTK2, a fibroblast-specific circular RNA that is significantly upregulated in pulmonary fibrosis patients and experimental models.

[Scientific Reports] Investigators presented a comprehensive workflow for the isolation and culture of primary human AT2 cells, including an efficient enzyme-based lung tissue digestion protocol and automated purification of human alveolar type 2 cells from both healthy and diseased lungs.

[Scientific Reports] The authors investigated the impact of KDM6B on macrophage processes during sepsis-induced acute lung injury and elucidated the underlying molecular mechanisms.

[Cell Research] Researchers performed whole-genome and transcriptome sequencing on 1008 lung adenocarcinoma samples from 954 patients who underwent surgery at Fudan University Shanghai Cancer Center, with comprehensive follow-up data.

[Science Advances] Scientists investigated the real-time link between oligomerization of oncogenic and resistant epidermal growth factor receptor (EGFR) mutants and downstream signaling using a fluorescent protein–based proximity probe and signaling reporter in living cells.

[Cell Reports] The authors identified the circular RNA circATF6, which is specifically downregulated in drug-tolerant persister cells due to regulation by the splicing factor ADAR1.

[Cell Death & Disease] Researchers found that centrosomal microtubule formation was increased in osimertinib-resistant NSCLC cells, and calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) was identified as the key molecule responsible for the change of microtubule morphology.

[Biomedical Engineering Online] Investigators focus on the structure and the composition of supporting cells of organ-on-a-chip, whose most notable feature is its biomimetic representation of the human body.

[Boehringer Ingelheim] China’s National Medical Products Administration has approved JASCAYD^® as the first new treatment for adults with progressive pulmonary fibrosis in more than five years, marking a breakthrough for millions affected by the life-threatening lung condition.

[Nature Communications] Scientists showed that in the liver, the glucocorticoid receptor is required for the metabolic response to caloric restriction.

[Science Advances] Investigators identified chitinase 3-like 1 (CHI3L1) as a key mediator linking immune activation to fibrotic remodeling in metabolic dysfunction-associated steatohepatitis (MASH).