Keep Current with the Latest in Cell Biology Research
The porcine small intestinal epithelial cell line IPEC-J2 was used to assess the ameliorative effects of alginate oligosaccharide on tumour necrosis factor-α-induced intestinal epithelial cell injury.
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Investigators generated muscle stem cell‐specific androgen receptor and estrogen receptor 2 double knockout mice and pharmacologically inhibited the hypothalamic–pituitary–gonadal axis to mimic decreased serum levels of sex steroid hormones in aged mice.
[Journal of Cachexia Sarcopenia and Muscle]
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Kim, J.-H., Park, I., Shin, H. R., Rhee, J., Seo, J.-Y., Jo, Y.-W., Yoo, K., Hann, S.-H., Kang, J.-S., Park, J., Kim, Y. L., Moon, J.-Y., Choi, M. H., & Kong, Y.-Y. (n.d.). The hypothalamic–pituitary–gonadal axis controls muscle stem cell senescence through autophagosome clearance. Journal of Cachexia, Sarcopenia and Muscle, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcsm.12653 Cite
Scientists report that SON, a chromosome 21-encoded DNA- and RNA-binding protein, inhibits megakaryocytic differentiation by suppressing RUNX1 and the megakaryocytic gene expression program.
[Cancer Gene Therapy]
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Vukadin, L., Kim, J.-H., Park, E. Y., Stone, J. K., Ungerleider, N., Baddoo, M. C., Kong, H. K., Richard, A., Tran, J., Giannini, H., Flemington, E. K., Lim, S.-T. S., & Ahn, E.-Y. E. (2020). SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia. Cancer Gene Therapy, 1–16. https://doi.org/10.1038/s41417-020-00262-9 Cite
The authors observed altered interactions between coactivator-associated arginine methyltransferase 1 (CARM1) and AMP-activated protein kinase (AMPK) and its network, including forkhead box protein O1, during muscle disuse.
This report describes the effects of full-length, wild-type APC (fl-APC) on cell-cell adhesion genes and p120-catenin isoform switching in SW480 colon cancer cells: fl-APC increased the expression of genes implicated in cell-cell adhesion, whereas the expression of negative regulators of E-cadherin were decreased.
[Molecular Biology of the Cell]
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PMV Pharmaceuticals, Inc. announced dosing of the first patient in its Phase I/II clinical trial evaluating PC14586, the company’s investigational lead compound that targets the Y220C mutant of p53.
[PMV Pharmaceuticals, Inc.]
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Researchers identified nine distinct major clusters including myeloid‐derived cells, fibroblast/fibro/adipogenic progenitors, and skeletal muscle stem cells in glycerol‐injured skeletal muscle.
[Journal of Cachexia Sarcopenia and Muscle]
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Xu, Z., You, W., Chen, W., Zhou, Y., Nong, Q., Valencak, T. G., Wang, Y., & Shan, T. (n.d.). Single-cell RNA sequencing and lipidomics reveal cell and lipid dynamics of fat infiltration in skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcsm.12643 Cite
Scientists explored the investigative mechanism of salidroside on LPS-induced acute lung injury/acute respiratory distress syndrome.
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Zheng, L., Su, J., Zhang, Z., Jiang, L., Wei, J., Xu, X., & Lv, S. (2020). Salidroside regulates inflammatory pathway of alveolar macrophages by influencing the secretion of miRNA-146a exosomes by lung epithelial cells. Scientific Reports, 10(1), 20750. https://doi.org/10.1038/s41598-020-77448-6 Cite
The authors utilized confluent Caco‐2 cell monolayers as in vitro model of intestinal epithelial cells to investigate the potential role of autophagy in the pathophysiology of cryptosporidiosis.
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Priyamvada, S., Jayawardena, D., Bhalala, J., Kumar, A., Anbazhagan, A. N., Alrefai, W. A., Borthakur, A., & Dudeja, P. K. (n.d.). Cryptosporidium parvum infection induces autophagy in intestinal epithelial cells. Cellular Microbiology, n/a(n/a), e13298. https://doi.org/https://doi.org/10.1111/cmi.13298 Cite
The authors discuss the recent advances in the field of epigenetics of non-melanoma skin cancer. Particularly, the role of DNA methylation, histone hyperacetylation and non-coding RNA such as long-chain noncoding RNAs, circular RNAs and miRNA in the disease progression are summarized.
[Seminars in Cancer Biology]
To address the role of the internalization mode, scientists performed infection studies at low temperature as a tool to interfere with endocytic pathways. Successful Herpes simplex virus-1 entry in primary human keratinocytes and HaCaT cells were observed even at 7°C, although delayed compared to infection at 37°C.
[Journal of Virology]