[Proceedings of the National Academy of Sciences of the United States of America] The authors systematically deciphered the precise interaction mechanism between SNORD78 and the m⁶A reader IMP2 in colorectal cancer.

[NPJ Precision Oncology] As one of the Cullin RING Ligase 4 adapters, DNA damage-binding protein 1 - and CUL4 correlation factor 13 (DCAF13) appeared strongly expressed in different tumors. Scientists' findings confirm enhanced expression of DCAF13 in tissues of colorectal cance origin and related cell.

[Cell Death & Disease] Researchers showed that extracellular matrix stiffness drives colorectal cancer progression by activating Piezo1-dependent cholesterol synthesis.

[Journal of Translational Medicine] Investigators uncovered a previously uncharacterized Beclin1-dependent EGFR/β-catenin regulatory cascade in colorectal cancer.

[Biology Direct] Scientists found methyltransferase-like protein-1 (METTL1), the key m7G methyltransferase, is highly expressed in colorectal cancer tissues via whole-transcriptome sequencing, qRT-PCR and immunohistochemical analysis.

[Molecular Carcinogenesis] To assess the impact of zinc finger protein 695 (ZNF695) on colorectal cancer tumor progression, the authors generated a xenograft model utilizing nude mice.

[Biochemical and Biophysical Research Communications] Investigators aim to discuss the future potential of prime editing as a new generation of genome engineering to identify precise approaches to correct TP53 mutations in colorectal cancer.

[The American Society for Clinical Pathology] The American Society for Clinical Pathology (ASCP), in collaboration with Pfizer and with participation from the American Society of Clinical Oncology, announced the recipients of its metastatic colorectal cancer Quality Improvement Grant Program.

[AcroCyte Therapeutics, Inc.] AcroCyte Therapeutics Inc. today that it has been selected to receive funding from the Advanced Research Projects Agency for Health (ARPA‑H) to advance scalable human organoid technologies for regenerative medicine applications.

[Nature Cell Biology] Investigators leveraged single-cell RNA-sequencing data to build a Xenium spatial transcriptomics gene panel covering the cell diversity of the human small intestine. They leveraged this high-resolution atlas to interrogate cell–cell signaling and benchmark PSC-derived human intestinal organoids.

[Journal of Neuroinflammation] Scientists demonstrated that subcutaneous transplantation of lung organoids ameliorated cognitive dysfunction in a mouse model of bilateral common carotid artery stenosis.

[Stem Cell Research & Therapy] Scientists established a patient-derived decidual organoid model. In this in vivo recurrent spontaneous abortion model, recombinant human granulocyte colony-stimulating factor (rhG-CSF) exerted protective effects by promoting proliferation, inhibiting apoptosis, and enhancing angiogenesis.