[Nature Communications] Researchers established a human iPSC-derived cholangiocyte-like cell organoid model that can be infected by human cytomegalovirus, which results in reduced organoid growth, a deformed structure, and a loss of barrier function.

[Advanced Science] To illuminate early changes in Alzheimer's disease, researchers developed a cerebrocortical organoid model with improved methodology.

[Advanced Science] Scientists generated fetal-like tendon organoids from adult tendon stem/progenitor cells using a serum-free 3D culture system that recapitulated the in vivo microenvironment.

[Bioactive Materials] Investigators introduced a spatiotemporal microneedle platform that synergistically combines protoporphyrin IX-mediated sonodynamic therapy for precise tumor eradication with chondral organoid-driven regeneration, leveraging differential mechanical cues for lineage-specific guidance.

[Advanced Healthcare Materials] The authors presented a tooth-bone integrated organoid strategy that synchronously reconstructs bone and dental implant structures in vitro, aiming to achieve dual restoration of structure and function post-implantation.

[Aging Cell] Researchers introduced mouse bladder epithelium-derived organoids (mBEDOs) as a scalable platform to model urothelial aging. mBEDOs from aged mice recapitulate key features of age-associated cellular reprogramming, including oxidative stress, senescence, and DNA damage.

[Cell Reports] To promote hair cell maturation, scientists tested the effects of the thyroid hormone thyroxine on Prestin expression in human cochlear organoids.

[Journal of Colloid and Interface Science] Investigators developed a cancer patient-derived organoid platform for evaluating hydrophilic metallic MoS₂ nanosheets in colorectal cancer.

[Cell Communication and Signaling] Researchers established the first long-term, genetically stable human vaginal epithelial organoids using a tailored Matrigel-based culture medium that preserves the native stratified squamous architecture.

[Stem Cell Reports] Using automated live-cell single-molecule tracking in intestinal organoid models, scientists revealed an expression-level-independent decrease in the fraction of immobile sex-determining region Y box 9 (SOX9) molecules during differentiation from ∼48% to ∼38%, largely dependent on DNA binding.

[Biomaterials Advances] The authors integrate cutting-edge technologies such as organ-on-a-chip and CRISPR/Cas9 gene editing to summarize the multidimensional generation strategy of breast cancer organoids and discuss the clinical value of translation from diagnosis to therapy.

[Gameto] Gameto announced that it has exclusively licensed additional intellectual property from Harvard University related to the induction of meiosis in human cells. This meiosis-induction approach will be integrated with its proprietary ovarian organoid platform to induce human oogonia to enter early meiotic stages in vitro.