[Advanced Materials] A detailed analysis of scaffolds coated with specific membrane components or entire cell membranes is presented, with applications in skin and wound healing, bone regeneration, neural repair, and vascular grafts.

[Molecular Cancer] The authors review the roles of cancer-associated fibroblasts within the TME during cancer progression and the development of cachexia.

[] Gel4Med, Inc., announced it has been awarded highly competitive funding from the National Institutes of Health (NIH) Small Business Innovation Research program to support the continued development of its advanced wound care and surgical reconstruction portfolio.

[American Journal of Clinical Dermatology] Scientists outline mechanisms driving resistance to anti-PD-1 therapy, including both tumor-intrinsic and tumor-extrinsic factors, and discuss biomarkers relevant to clinical practice in melanoma.

[Genome Biology] Researchers generated helicase, lymphoid-specific (HELLS) and DNA methyltransferase 3A and B (DNMT3A/B) knockout hPSCs and reported telomere-to-telomere maps of whole genome bisulfite sequencing data combined with ATAC-sequencing.

[Journal of Hepatology] Researchers discovered that targeting the mevalonate pathway promotes ferroptosis in HCC by impairing CoQ10 synthesis and selenoprotein translation.

[Cell Reports] Scientists characterized the specific residues of IκBα that allow the generation of separation-of-function mutants that are defective for either NF-κB-related or chromatin-related activities.

[Journal of Clinical Investigation] Investigators demonstrated that NFAT5 is critical for the survival and proliferation of intestinal epithelial cells and that its deficiency accelerates chemically induced or spontaneous colitis in mice.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Pathogens can hijack intestinal stem cell (ISC) functions to their advantage and establish infections. In this review, the authors explore the mechanisms used by pathogens to exploit ISCs.

[Oncogenesis] Using multiple human and murine CRC models, researchers revealed that GSK-3 inhibition strongly sensitized to BH3 mimetic-induced killing.

[Oncogene] The authors used liquid chromatography/mass spectrometry analyses on Drosophila CRC tumor models to identify multiple metabolites in the glucuronidation pathway as upregulated in trametinib-resistant RAS/APC/P53 tumors compared to trametinib-sensitive Ras^G12V single mutant tumours.

[C-Path] Critical Path Institute’s^® (C-Path) Translational Therapeutics Accelerator announced a $200,000 grant to Dr. Carlos Subauste to advance a promising new therapy for IBD.