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Dysregulated Alveolar Type 2 Epithelial Cell Proteostasis Promotes Fibrogenic Macrophage Migration Inhibitory Factor-CD74 Signaling
[Science Translational Medicine] Scientists showed that ubiquitin-proteasome system disruption in alveolar type 2 epithelial cells amplifies profibrotic signaling to macrophages through macrophage migration inhibitory factor family proteins in several models.
Methylated circPTK2 As a Driver of Fibroblast Activation in Pulmonary Fibrosis
[Molecular Therapy] Researchers identified circPTK2, a fibroblast-specific circular RNA that is significantly upregulated in pulmonary fibrosis patients and experimental models.
High-Throughput Isolation of Normal and Pulmonary Fibrosis Human Alveolar Epithelial Cells
[Scientific Reports] Investigators presented a comprehensive workflow for the isolation and culture of primary human AT2 cells, including an efficient enzyme-based lung tissue digestion protocol and automated purification of human alveolar type 2 cells from both healthy and diseased lungs.
KDM6B Induces Demethylation of H3K27me3 in MFN1 to Modulate Aberrant Mitophagy in Sepsis-Induced Acute Lung Injury
[Scientific Reports] The authors investigated the impact of KDM6B on macrophage processes during sepsis-induced acute lung injury and elucidated the underlying molecular mechanisms.
Genomic and Transcriptomic Dynamics in the Stepwise Progression of Lung Adenocarcinoma
[Cell Research] Researchers performed whole-genome and transcriptome sequencing on 1008 lung adenocarcinoma samples from 954 patients who underwent surgery at Fudan University Shanghai Cancer Center, with comprehensive follow-up data.
Steric Disruption of EGFR Oligomerization Overcomes Therapy Resistance in Non-Small Cell Lung Cancer
[Science Advances] Scientists investigated the real-time link between oligomerization of oncogenic and resistant epidermal growth factor receptor (EGFR) mutants and downstream signaling using a fluorescent protein–based proximity probe and signaling reporter in living cells.
circATF6 Triggers Calcium Overload to Synergize with EGFR-TKI in Non-Small Cell Lung Cancer via Modulation of Proteostasis
[Cell Reports] The authors identified the circular RNA circATF6, which is specifically downregulated in drug-tolerant persister cells due to regulation by the splicing factor ADAR1.
Cytoskeletal Remodeling via CAMSAP3 Downregulation Drives Resistance to Osimertinib in NSCLC Cells
[Cell Death & Disease] Researchers found that centrosomal microtubule formation was increased in osimertinib-resistant NSCLC cells, and calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) was identified as the key molecule responsible for the change of microtubule morphology.
Application and Prospects of Lung Organ-on-a-Chip in the Development of New Drugs
[Biomedical Engineering Online] Investigators focus on the structure and the composition of supporting cells of organ-on-a-chip, whose most notable feature is its biomimetic representation of the human body.
JASCAYD® (Nerandomilast) Receives First Regulatory Approval for Progressive Pulmonary Fibrosis in China
[Boehringer Ingelheim] China’s National Medical Products Administration has approved JASCAYD® as the first new treatment for adults with progressive pulmonary fibrosis in more than five years, marking a breakthrough for millions affected by the life-threatening lung condition.
Hepatic Metabolic Reprogramming in Male Mice during Short-Term Caloric Restriction Involves Enhanced Glucocorticoid Rhythms
[Nature Communications] Scientists showed that in the liver, the glucocorticoid receptor is required for the metabolic response to caloric restriction.
Decoding the CHI3L1/IL-13Rα2 Signaling Nexus in MASH-Fibrosis Pathogenesis
[Science Advances] Investigators identified chitinase 3-like 1 (CHI3L1) as a key mediator linking immune activation to fibrotic remodeling in metabolic dysfunction-associated steatohepatitis (MASH).

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