[Nature Reviews Immunology] Recent genomic and mechanistic studies reveal that peripheral T cell lymphomas frequently ‘hijack’ signaling pathways that normally govern T cell activation at the immunological synapse.

[Nature Communications] Researchers uncovered a role for IgA autoantibodies in Hidradenitis suppurativa, implicating them as central drivers of chronic inflammation, fibrosis, and immune crosstalk across neutrophils, macrophages, fibroblasts, and T cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists presented an in-depth characterization of peripheral and intrathecal immune cell populations in individuals with anti-GAD65 autoimmune neurological syndromes compared with noninflammatory and healthy controls, using multidimensional flow cytometry, histology, and single-cell RNA sequencing combined with immune repertoire profiling.

[Nature Immunology] Researchers identified the transcription factor ZFP148 as a repressor of CD8+ T cell effector differentiation. Cancer patients with lower ZNF148 expression in tumor-infiltrating CD8+ T cells showed improved responsiveness to immunotherapies.

[Nature Cell Biology] The authors identified a COTL1high natural killer subset that mediates immune checkpoint blockade responsiveness in patients with impaired tumour-specific major histocompatibility complex class I.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists profiled peripheral and central T cell responses in patients with multiple system atrophy (MSA), in comparison with Parkinson’s disease and healthy control cohorts. They demonstrated that peripheral T cells from MSA patients are activated and skewed toward cytotoxic and inflammatory phenotypes.

[Immunity] The authors discuss how aging shapes memory T cell compartments—from repertoire contraction and differentiation to altered metabolic, transcriptional, and epigenetic states.

[Trends In Immunology] Although traditionally viewed as rapid and potent innate effectors against infected or transformed cells, NK cells possess adaptive capabilities, such as antigen-specific clonal expansion and the generation of long-lived memory cells.

[University of Buffalo] The FDA has approved the immune checkpoint inhibitor nivolumab in combination with chemotherapy for adults and adolescents 12 and older with previously untreated Stage III/IV classic Hodgkin lymphoma.

[Cancer Immunology Research] Mammaglobin-A (Mam-A) is a tumor-associated antigen expressed in >50% of patients with breast cancer. To evaluate the potential of the Mam-A vaccine, researchers initiated a Phase Ib clinical trial in patients with ER+ breast cancer. Ex vivo enzyme-linked immunospot analysis of peripheral blood mononuclear cells demonstrated that vaccination induces Mam-A–specific T cells in 8 of 13 patients.

[Journal for Immunotherapy of Cancer] The authors trace four phases of cancer vaccine evolution, review the technological advances that enabled the discovery of the dark immunopeptidome, and discuss how these findings challenge established paradigms and reinvigorate interest in shared tumor antigens.

[Cancer Cell International] Investigators highlight recent advances in CD8+ T cell metabolic regulation, the impact of the tumor microenvironment, and therapeutic approaches to reinvigorate exhausted T cells.