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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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Four-Dimensional Molecular Mapping from a Spatial Snapshot Reveals the Dynamics of Hair Follicle Organogenesis
[Cell] Researchers developed 3D DNase-Enhanced Expression Profiling, a deep-tissue spatial transcriptomics approach that reconstructs the four-dimensional dynamics of hair follicle development from a single tissue snapshot.
Chemotactic Self-Organization Captures the Dynamics of Mammalian Hair Follicle Patterning
[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that chemotactic self-organization governs mammalian hair follicle patterning, explaining how distinct hair patterns emerge across species.
Biofunctionalization of Bacterial Cellulose with FucoPol Enhances Keratinocyte Activity and Wound Closure
[ACS Applied Bio Materials] The authors enhanced bacterial cellulose wound dressings with FucoPol, boosting keratinocyte activity and accelerating wound closure for improved skin repair.
Cytosolic EZH2-IMPDH2 Complexes Regulate Melanoma Progression and Metastasis via GTP
[Molecular Cell] Investigators uncovered a methyltransferase-independent role for enhancer of zeste homolog 2 (EZH2) in melanoma, showing that cytosolic EZH2–IMPDH2 complexes drive GTP synthesis, tumor progression, and metastasis.
Matrix Stiffness Drives Squamous Cell Carcinoma Progression via a Piezo1-Mediated Mechanotransduction Feedback Loop
[Journal of Advanced Research] Researchers showed that matrix stiffness fuels squamous cell carcinoma progression through a self-reinforcing Piezo1–RCC2–YAP mechanotransduction loop, identifying Piezo1 as a potential therapeutic target.
A ZDHHC3-USP5-PTRF Axis Links Palmitoylation to Ferroptosis-Associated Phenotypes in Melanoma
[Cell Death & Disease] Scientists characterized ubiquitin‑specific peptidase 5 (USP5) using proteomic, biochemical, and functional approaches. USP5 was upregulated in melanoma and promoted proliferation, migration, and invasion.
Nanotechnology in Plastic and Reconstructive Surgery: Emerging Innovations in Wound Healing, Aesthetic Applications, and Skin Regeneration
[ACS Applied Bio Materials] Investigators highlight how nanotechnology is transforming plastic and reconstructive surgery, advancing wound healing, tissue regeneration, implant design, and aesthetic therapies.
KI Researcher Awarded International Fellowship for Melanoma Research
[Karolinska Institutet ] Matthew Hunt at Karolinska Institutet (KI) is one of the recipients of the IBSA Foundation Fellowships 2025. He is awarded the fellowship for a research project on new treatment strategies for aggressive skin cancer.
Keratinocyte-Derived Apoptotic Nanovehicles Reprogram Cutaneous Dendritic Cells to Ameliorate Psoriasis
[ACS Nano] A nanovehicle fabricated using keratinocyte-derived apoptotic vesicles is proposed to enhance drug accumulation in dendritic cells (DCs) and synergistically modulate DC function.
A Stretch-Responsive Fibroblast Program Promotes Epidermal Stem Cell Self-Renewal during Skin Expansion
[Nature Communications] Researchers mapped the fibroblast transcriptional response to stretching in vivo and demonstrated that stretching forces fibroblasts to exit their quiescent state and restart proliferation.
DNA Hydrogel-Delivered Hypoxic Exosomes Alleviate Radiation-Induced Skin Injury by Stabilizing AKT
[Journal of Nanobiotechnology] Investigators aimed to enhance the targeted delivery efficiency of exosomes in skin tissues, systematically evaluated the therapeutic effects of hypoxia-preconditioned adipose-derived stem cell-derived exosomes in radiation-induced skin injury repair, and elucidated the underlying molecular mechanisms.
HIF-1α Attenuates Ferroptosis-Associated Dermal Fibroblast Senescence via Modulation of NF-κB-DPP4 Signaling
[Journal of Translational Medicine] The authors determined whether hypoxia-inducible factor-1α (HIF-1α) modulates ferroptosis-associated senescence in human dermal fibroblasts and explored the involvement of NF-κB– dipeptidyl peptidase-4 (DPP4) signaling.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
