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Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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Bristol Myers Squibb Receives European Commission Approval of Sotyktu (deucravacitinib) for the Treatment of Active Psoriatic Arthritis in Adults
[ Bristol Myers Squibb] Bristol Myers Squibb announced that the European Commission has granted approval to Sotyktu (deucravacitinib), alone or in combination with methotrexate, for the treatment of active psoriatic arthritis in adults who have had an inadequate response or who have been intolerant to a prior disease-modifying antirheumatic therapy.
ACTR3 Enhances the Hyperproliferation of Psoriatic Keratinocytes by Activating the TAK1-MK2-HSP27 Pathway
[FEBS Journal] Investigators demonstrated that elevated actin-associated protein 3 (ACTR3) expression in cutaneous tumours and psoriasis promotes abnormal keratinocyte proliferation in psoriasis.
Novel CRISPR-Cas9 BAP1 Knockout Pre-Clinical Tumor Model Recapitulates Human Melanoma Tumorigenesis and Immune Evolution
[Communications Biology] Scientists generated a syngeneic BAP1 knockout melanocyte tumor line using CRISPR-Cas9. They then evaluated its functional and immunological impact in immune-competent mice, including its ability to recapitulate metabolic and immunosuppressive features of human BAP1-deficient melanomas.
T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets
[Aging Cell] The authors explore the role of T cell immunosenescence in the pathogenesis of common inflammatory skin diseases, including psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis.
GD3s-Mediated Lipid Metabolism Reprograming Promotes Proliferation and Metastasis of Melanoma
[Journal of Translational Medicine] Investigators uncovered a novel mechanism by which GD3 synthase (GD3s) modulate aberrant lipid metabolism and promote the progression of melanoma. GD3s promoted the proliferation and metastasis of melanoma by reprograming lipid metabolism.
Spliceosomal Mutation Drives Melanoma Tumorigenesis via Lineage-Specific RAS Activation
[Science Advances] Researchers introduced SF3B1K700E and SF3B1R625H mutations into both normal human melanocyte cells and a chronic myeloid leukemia cell line to investigate residue-specific splicing abnormalities by the two different SF3B1 hotspot mutations.
BLK Suppresses Melanoma Progression and Improves Prognosis via Pyroptosis Regulation
[Scientific Reports] Functional assays in human melanoma cell lines revealed that B lymphocyte tyrosine kinase (BLK)o verexpression significantly suppresses melanoma cell proliferation, migration, invasion, and is associated with pyroptosis, characterized by Caspase-3 activation and subsequent GSDME cleavage.
DUSP1 Deficiency Accelerates UVB‑Induced HDF Cell Senescence by Regulating Ferroptosis
[Photochemical & Photobiological Sciences] Scientists investigated the role of ferroptosis and the regulatory mechanism of dual‑specificity phosphatase 1 (DUSP1) in a ultraviolet (UVB)‑induced stress‑induced premature senescence model of human dermal fibroblasts. They suggest that DUSP1 might serve as a novel therapeutic target for mitigating skin photoaging.
LEO Pharma Expands Its Psoriasis Portfolio in China with NMPA Approval of Enstilar®
[LEO Pharma A/S] LEO Pharma A/S announced that China's National Medical Products Administration (NMPA) has approved Enstilar® (calcipotriene/betamethasone dipropionate) to treat adult patients in China living with plaque psoriasis.
Somatic Mutations Distinguish Melanocyte Subpopulations in Human Skin
[Nature Cell Biology] Investigators showed that a population of melanocytes with low mutation burden persists in sun-exposed epidermis. These cells were smaller, less dendritic, and exhibit stem-like expression profiles when compared to melanocytes carrying high mutation burdens.
Trk1 Potassium Transport Is Crucial for Effective Candidozyma Auris Skin Colonization
[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified potassium (K+) as a crucial nutrient for efficient growth in the skin niche. They showed that putative high-affinity K+ transporter Trk1 is required for Candidozyma auris growth on human skin ex vivo.
Radial Constraint of Plastically Compressed Human Dermo-Epidermal Skin Substitutes Mitigates Contraction and Enhances Structural Maturity
[Biofabrication] Researchers developed a customized anti-shrinkage device designed to physically constrain the substitute while remaining compatible with the established fabrication process of plastically compressed dermo-epidermal skin substitutes.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
