Wnt/β-Catenin Signaling Pathway Induces Autophagy-Mediated Temozolomide-Resistance in Human Glioblastoma

Investigators demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) was responsible for temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) through ATG9B. DAB2IP sensitized GBM to TMZ and suppressed TMZ-induced autophagy by negatively regulating ATG9B expression.
[Cell Death & Disease]
Yun, E.-J., Kim, S., Hsieh, J.-T., & Baek, S. T. (2020). Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma. Cell Death & Disease, 11(9), 1–10. https://doi.org/10.1038/s41419-020-02988-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Autophagy Is Induced and Supports Virus Replication in Enterovirus A71-Infected Human Primary Neuronal Cells

Human neural stem cells and IMR-32 neuroblastoma cells were differentiated into neuronal cells for this study. Although the neuronal cells were permissive to EV-A71 infection, EV-A71 infection did not induce an obvious cytopathic effect on the neuronal cells.
[Scientific Reports]
Lin, J.-Y., & Huang, H.-I. (2020). Autophagy is induced and supports virus replication in Enterovirus A71-infected human primary neuronal cells. Scientific Reports, 10(1), 15234. https://doi.org/10.1038/s41598-020-71970-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System

The authors showed that glia could be reprogrammed to promote morphological and functional regeneration after central nervous system injury in Drosophila via increased glycolysis.
[Cell Metabolism]
Li, F., Sami, A., Noristani, H. N., Slattery, K., Qiu, J., Groves, T., Wang, S., Veerasammy, K., Chen, Y. X., Morales, J., Haynes, P., Sehgal, A., He, Y., Li, S., & Song, Y. (2020). Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.08.015 Cite
AbstractPress ReleaseGraphical Abstract
Bookmark

No account yet? Register

0
Share

CuraSen Therapeutics Announces First Subjects Dosed in Phase I Clinical Trial with First Proprietary Compound, CST-2032, Targeting Neurodegenerative Disease

CuraSen Therapeutics, Inc. announced that it has dosed its first subjects in a multi-part, Phase 1 clinical study with CST-2032, the company’s first proprietary compound intended for the treatment of ­neurodegenerative disease.
[CuraSen Therapeutics, Inc.]
Press Release
Bookmark

No account yet? Register

0
Share

Brainstorm Announces Grant of a New Japanese Patent for NurOwn®

Brainstorm Cell Therapeutics Inc. announced that the Japanese Patent Office has granted Brainstorm’s Japanese Patent, number: 6,753,887, titled: ‘Methods of Generating Mesenchymal Stem Cells which Secrete Neurotrophic Factors’.
[Brainstorm Cell Therapeutics Inc.]
Press Release
Bookmark

No account yet? Register

0
Share

The Effects of Microglia‐ and Astrocyte‐Derived Factors on Neurogenesis in Health and Disease

The authors describe how glial cells play a role in adult hippocampal neurogenesis in both health and disease, especially focusing on glia‐derived factors.
[European Journal of Neuroscience]
Araki, T., Ikegaya, Y., & Koyama, R. (2020). The effects of microglia‐ and astrocyte‐derived factors on neurogenesis in health and disease. European Journal of Neuroscience. https://doi.org/10.1111/ejn.14969 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Bilirubin Inhibits Lipid Raft Dependent Functions of L1 Cell Adhesion Molecule in Rat Pup Cerebellar Granule Neurons

Cerebellar granule neurons were plated on poly-L-lysine overnight, and neurite length was determined after one hour treatment with L1 cell adhesion molecule (L1) alone or L1 and bilirubin.
[Pediatric Research]
Kitchen, S. T., Tang, N., He, M., Ly, E., Mooney, S. M., & Bearer, C. F. (2020). Bilirubin inhibits lipid raft dependent functions of L1 cell adhesion molecule in rat pup cerebellar granule neurons. Pediatric Research, 1–8. https://doi.org/10.1038/s41390-020-01156-0 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Attenuating Hypoxia Driven Malignant Behavior in Glioblastoma with a Novel Hypoxia-Inducible Factor 2 Alpha Inhibitor

Researchers investigated a novel hypoxia inducible factor 2α inhibitor, PT2385, both in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models of glioblastoma.
[Scientific Reports]
Renfrow, J. J., Soike, M. H., West, J. L., Ramkissoon, S. H., Metheny-Barlow, L., Mott, R. T., Kittel, C. A., D’Agostino, R. B., Tatter, S. B., Laxton, A. W., Frenkel, M. B., Hawkins, G. A., Herpai, D., Sanders, S., Sarkaria, J. N., Lesser, G. J., Debinski, W., & Strowd, R. E. (2020). Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitor. Scientific Reports, 10(1), 15195. https://doi.org/10.1038/s41598-020-72290-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Modeling HIV-1 Neuropathogenesis Using Three-Dimensional Human Brain Organoids (hBORGs) with HIV-1 Infected Microglia

The authors developed a three-dimensional hBORG model containing major cell types important for HIV-1 neuropathogenesis; neurons and astrocytes along with incorporation of HIV-infected microglia.
[Scientific Reports]
dos Reis, R. S., Sant, S., Keeney, H., Wagner, M. C. E., & Ayyavoo, V. (2020). Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia. Scientific Reports, 10(1), 15209. https://doi.org/10.1038/s41598-020-72214-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis

Researchers found that the chemokines CXCL1 and CCL2 were induced in the brain following HSV-1 infection. Ccr2-deficient mice had reduced monocyte recruitment, uncontrolled viral replication, and increased morbidity.
[Cell Reports]
Michael, B. D., Bricio-Moreno, L., Sorensen, E. W., Miyabe, Y., Lian, J., Solomon, T., Kurt-Jones, E. A., & Luster, A. D. (2020). Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis. Cell Reports, 32(11). https://doi.org/10.1016/j.celrep.2020.108150 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Sensing of Nutrients by CPT1C Controls SAC1 Activity to Regulate AMPA Receptor Trafficking

Researchers demonstrated across different metabolic stress conditions that modulate malonyl-CoA levels in cortical neurons that carnitine palmitoyltransferase 1C (CPT1C) regulated the trafficking of the major AMPA receptor subunit, GluA1, through the phosphatidyl-inositol-4-phosphate (PI(4)P) phosphatase SAC1.
[Journal of Cell Biology]
Casas, M., Fadó, R., Domínguez, J. L., Roig, A., Kaku, M., Chohnan, S., Solé, M., Unzeta, M., Miñano-Molina, A. J., Rodríguez-Álvarez, J., Dickson, E. J., & Casals, N. (2020). Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking. Journal of Cell Biology, 219(10). https://doi.org/10.1083/jcb.201912045 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share