Researchers showed knocking out IL-17 contributed to regulating PI3K/Akt pathway, promoting neural stem cell proliferation, and neurogenesis after ischemic stroke.
[Cell Death Discovery]
6445218 8SHRVFS9 items 1 apa default asc 1
Sun, L., Han, R., Guo, F., Chen, H., Wang, W., Chen, Z., Liu, W., Sun, X., & Gao, C. (2020). Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway. Cell Death Discovery, 6(1), 1–18. https://doi.org/10.1038/s41420-020-00298-8 Cite
The authors highlight the latest evidence base pertaining to the complex Aβ–tau interaction and underscore its crucial importance to elucidating disease pathogenesis and the design of next-generation Alzheimer’s disease therapeutic trials.
Investigators encapsulated homotypic spinal cord neural stem cells in an alginate-based neural ribbon delivery platform. They performed a comprehensive in vitro analysis and qualitatively demonstrated graft survival and injury site retention using a rat C4 hemi-contusion model.
6445218 WJWWFXY7 items 1 apa default asc 1
Investigators describe a medulloblastoma model using induced pluripotent stem cell-derived human neuroepithelial stem cells generated from a Gorlin syndrome patient carrying a germline mutation in the sonic hedgehogreceptor PTCH1.
[Proceedings of the National Academy of Sciences of the United States of America]
6445212 F7SH4EDX items 1 apa default asc 1
Susanto, E., Navarro, A. M., Zhou, L., Sundström, A., Bree, N. van, Stantic, M., Moslem, M., Tailor, J., Rietdijk, J., Zubillaga, V., Hübner, J.-M., Weishaupt, H., Wolfsberger, J., Alafuzoff, I., Nordgren, A., Magnaldo, T., Siesjö, P., Johnsen, J. I., Kool, M., … Wilhelm, M. (2020). Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1920521117 Cite
By correlating intracellular metabolite levels with radiation resistance across dozens of genomically-distinct models of glioblastoma, researchers find that purine metabolites, especially guanylates, strongly correlate with radiation resistance.
6606345 K86XLNPI items 1 apa default asc 1
Zhou, W., Yao, Y., Scott, A. J., Wilder-Romans, K., Dresser, J. J., Werner, C. K., Sun, H., Pratt, D., Sajjakulnukit, P., Zhao, S. G., Davis, M., Nelson, B. S., Halbrook, C. J., Zhang, L., Gatto, F., Umemura, Y., Walker, A. K., Kachman, M., Sarkaria, J. N., … Wahl, D. R. (2020). Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nature Communications, 11(1), 3811. https://doi.org/10.1038/s41467-020-17512-x Cite
By implementing a highly efficient high-throughput screening platform using an in-house-constructed genome-wide human microRNA inhibitor library, scientists demonstrated that miR-1193 inhibition sensitized glioblastoma multiforme tumor cells with DNA-PKcs deficiency.
[Cell Death & Disease]
6606345 T9RDEEIR items 1 apa default asc 1
Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs | Cell Death & Disease. (n.d.). Retrieved August 5, 2020, from https://www.nature.com/articles/s41419-020-02812-3 Cite
Researchers developed a high-throughput screening and discovered that NG52, previously known as a yeast cell cycle-regulating kinase inhibitor, could inhibit the kinase activity of phosphoglycerate kinase 1.
[Acta Pharmacologica Sinica]
6606345 6KB4UJGF items 1 apa default asc 1
Scientists showed that notch signaling-deficient astrocytes could generate new neurons after injury. Using single-cell RNA sequencing, they found that, when notch signaling was blocked, astrocytes transitioned to a neural stem cell-like state.
[Cell Stem Cell]
The authors performed calcium imaging of neural stem/progenitor cell grafts in spinal cord injury sites in vivo and in adult spinal cord slices.
[Cell Stem Cell]
6606345 GTYTVLDS items 1 apa default asc 1
MODAG announced the successful completion of its first clinical trial of anle138b (NCT04208152) in healthy volunteers. Based on the positive Phase I study results, MODAG was also able to obtain additional funding of USD 1.4 million from The Michael J. Fox Foundation for parkinson’s research.
Researchers used single-cell RNA sequencing to characterize neurogenesis by notch-depleted striatal astrocytes in vivo.
Research conducted over the past 10 years has revealed that cortical GABAergic projection neurons are highly diverse in terms of molecular marker expression, synaptic targeting, activity pattern during distinct behavioural states and precise temporal recruitment relative to ongoing neuronal network oscillations.
[Nature Reviews Neuroscience]