Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Neuronal Dynamics Direct Cerebrospinal Fluid Perfusion and Brain Clearance

[Nature] The authors demonstrated that neural networks synchronized individual action potentials to create large-amplitude, rhythmic, and self-perpetuating ionic waves in the interstitial fluid of the brain.

Neural Conditional Ablation of the Protein Tyrosine Phosphatase Receptor Delta PTPRD Impairs Gliogenesis in the Developing Mouse Brain Cortex

[Frontiers in Cell and Developmental Biology] The authors developed a conditional knockout mouse model lacking phosphatase receptor delta (PTPRD) expression in telencephalon cells. They found that the lack of PTPRD in the mouse cortex reduces glial precursors, astrocytes, and oligodendrocytes.

Extracellular Vesicles from UTX-Knockout Endothelial Cells Boost Neural Stem Cell Differentiation in Spinal Cord Injury

[Cell Communication And Signaling] Two mouse models were used to investigate spinal cord injury: neural stem cells lineage-traced mice and mice with conditional Ubiquitously Transcribed Tetratripeptide Repeat on Chromosome X knockout in endothelial cells.

An Immunosuppressive Vascular Niche Drives Macrophage Polarization and Immunotherapy Resistance in Glioblastoma

[Science Advances] Scientists identify a distinct mesenchymal-like population of endothelial cells that form an immunosuppressive vascular niche in glioblastoma.

Multisensory Gamma Stimulation Promotes Glymphatic Clearance of Amyloid

[Nature] Researchers showed that multisensory gamma stimulation promoted the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer’s disease.

NOVA1 Acts as an Oncogenic RNA-Binding Protein to Regulate Cholesterol Homeostasis in Human Glioblastoma Cells

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists found that NOVA1 acted as an oncogenic factor in a glioblastoma multiforme cell line established from a patient.

Expression Patterns of Piezo1 in the Developing Mouse Forebrain

[Brain Structure & Function] Researchers conducted an RNAscope experiment to visualize the location of Piezo1 transcripts with embryonic neuronal/glial lineage cell markers.

Altered Hippocampal Neurogenesis in a Mouse Model of Autism Revealed by Genetic Polymorphisms and by Atypical Development of Newborn Neurons

[Scientific Reports] Investigators found coding non-synonymous single-nucleotide polymorphisms in 33 genes involved in the adult neurogenic process, as well as in 142 genes associated with the signature genetic profile of neural stem cells and neural progenitors.

Metabolic Rescue of α-Synuclein-Induced Neurodegeneration through Propionate Supplementation and Intestine-Neuron Signaling in C. elegans

[Cell Reports] Scientists found that the short-chain fatty acid propionate protected against α-synuclein-induced neuronal death and locomotion defects in a Caenorhabditis elegans model of Parkinson’s disease through bidirectional regulation between the intestine and neurons.

The lncRNA Snhg11, a New Candidate Contributing to Neurogenesis, Plasticity, and Memory Deficits in Down Syndrome

[Molecular Psychiatry] Researchers showed that that trisomy manifested as a highly specific modification of the transcriptome within distinct cell types. They observed a significant shift in the transcriptomic profile of granule cells in the dentate gyrus associated with trisomy.

ESCRT-I Protein UBAP1 Controls Ventricular Expansion and Cortical Neurogenesis via Modulating Adherens Junctions of Radial Glial Cells

[Cell Reports] The authors showed that conditional disruption of ubiquitin-associated protein 1 (UBAP1), a component of endosomal sorting complex required for transport (ESCRT), caused severe brain dysplasia and prenatal ventriculomegaly.

Neuralink Brain Chip: Advance Sparks Safety and Secrecy Concerns

[Nature] The first person to receive a brain-monitoring device from Neuralink can control a computer cursor with their min. But researchers say that this is not a major feat — and they are concerned about the secrecy around the device’s safety and performance.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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