Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Tanshinone IIA-Loaded Nanoparticle and Neural Stem Cell Therapy Enhances Recovery in a Pig Ischemic Stroke Mode

[Stem Cells Translational Medicine] Researchers evaluated the potential of Tan IIA drug-loaded nanoparticles to improve iPSC-derived neural stem cells engraftment and efficacy, thus potentially leading to enhanced cellular, tissue, and functional recovery in a translational pig ischemic stroke model.

NIH’s BRAIN Initiative Puts $500 Million Into Creating Most Detailed Ever Human Brain Atlas

[ScienceInsider] The BRAIN Initiative, the nine-year-old, multibillion-dollar US neuroscience effort, announced its most ambitious challenge yet: compiling the world’s most comprehensive map of cells in the human brain.

A Midbrain-Reticulotegmental Circuit Underlies Exaggerated Startle under Fear Emotions

[Molecular Psychiatry] The authors revealed a neural projection from dorsal raphe nucleus to a startle-controlling center reticulotegmental nucleus that mediated enhanced startle response under fear condition.

MEX3A Impairs DNA Mismatch Repair Signaling and Mediates Acquired Temozolomide Resistance in Glioblastoma

[Cancer Research] The authors reported significant upregulation of Mex-3 RNA binding family member A in bioblastoma tissues and cell lines following temozolomide treatment.

Ketogenic Diet Uncovers Differential Metabolic Plasticity of Brain Cells

[Science Advances] Scientists generated a proteome atlas of the major central nervous system cell types from young and adult mice, after feeding the therapeutically relevant low-carbohydrate, high-fat ketogenic diet and during neuroinflammation.

Parkinson-Causing Mutations in LRRK2 Impair the Physiological Tetramerization of Endogenous α-Synuclein in Human Neurons

[npj Parkinsons Disease] Patient neurons carrying G2019S, the most prevalent LRRK2 mutation, or R1441C each had decreased T:M ratios and pSer129 hyperphosphorylation of their endogenous αSyn along with increased phosphorylation of Rab10, a widely reported substrate of LRRK2 kinase activity.

Transcriptional Dynamics of Murine Motor Neuron Maturation In Vivo and In Vitro

[Nature Communications] Researchers showed that mouse motor neurons exhibited pervasive changes in gene expression and accessibility of associated regulatory regions from embryonic till juvenile age.

Complement C1q-Dependent Excitatory and Inhibitory Synapse Elimination by Astrocytes and Microglia in Alzheimer’s Disease Mouse Models

[Nature Aging] Researchers found relatively more excitatory synapse marker proteins in astrocytic lysosomes, whereas microglial lysosomes contained more inhibitory synapse material.

Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets

[Cancer Research] The authors performed the first broad epigenetic profiling of myeloid-derived suppressor cells (MDSC) subsets to define underlying cell-intrinsic differences in behavior and found that enhanced gene accessibility of cell adhesion programs in mMDSCs is linked to their tumor-accelerating ability in GBM models upon adoptive transfer.

SerpinB3 Drives Cancer Stem Cell Survival in Glioblastoma

[Cell Reports] Knockdown of SerpinB3 increased apoptosis and susceptibility to radiation therapy, and scientists found that SerpinB3 was essential to buffer cathepsin L-mediated cell death.

Angiocrine Extracellular Vesicles Impose Mesenchymal Reprogramming upon Proneural Glioma Stem Cells

[Nature Communications] Investigators document the secretory role of endothelial cells and their derived extracellular vesicles as drivers of proneural-to-mesenchymal reprogramming of glioma stem cells.

Non-Coding RNAs and Glioma: Focus on Cancer Stem Cells

[Molecular Therapy Oncolytics] Scientists provide recent findings on the role of ncRNAs in glioma development and progression, particularly their effects on cancer stem cells.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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