Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Transcriptional Regulation by PHGDH Drives Amyloid Pathology in Alzheimer’S Disease

April 24, 2025

[Cell] Researchers showed that altered expression of the late-onset Alzheimer's disease (AD) biomarker phosphoglycerate dehydrogenase (PHGDH) modulates AD pathology in mice and human brain organoids independent of its enzymatic activity.

Loss of Intracellular ATP Affects Axoplasmic Viscosity and Pathological Protein Aggregation in Mammalian Neurons

April 24, 2025

[Science Advances] The authors showed that intracellular adenosine triphosphate (ATP) regulated axoplasmic viscosity and protein aggregation in mammalian neurons.

Synaptophysin Accelerates Synaptic Vesicle Fusion by Expanding the Membrane upon Neurotransmitter Loading

April 24, 2025

[Science Advances] Researchers showed that during transmitter loading, synaptic vesicles substantially increased in size, which was reversible and required synaptophysin, an abundant membrane protein with an unclear function.

Progranulin Deficiency in the Brain: The Interplay between Neuronal and Non-Neuronal Cells

April 23, 2025

[Translational Neurodegeneration] The authors highlight the broad spectrum of clinical phenotypes associated with progranulin deficiency, including primary progressive aphasia and behavioral variant of frontotemporal dementia.

Dynamic Modulation of the Motor Neuron Translatome during Developmental Synapse Elimination

April 23, 2025

[Science Signaling] Scientists monitored translation, the process of active protein synthesis from mRNAs, in motor neurons in early postnatal mice and characterized the “translatome” that emerged and changed during synaptic pruning.

Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity

April 23, 2025

[Cancer Discovery] Researchers identified transcriptionally distinct types of mutation-harboring precancerous cells in our spontaneous, somatic mouse model recapitulating human glioblastoma evolution as well as in tumor-free subventricular zone tissues from patients.

BIN1 and Alzheimer’s Disease: The Tau Connection

April 23, 2025

[Trends In Neurosciences] Scientists discuss the multiple cerebral roles of bridging integrator 1 (BIN1), especially in regulating synaptic function, and the strong link between BIN1 and tau pathology.

Hypothalamic PNOC/NPY Neurons Constitute Mediators of Leptin-Controlled Energy Homeostasis

April 23, 2025

[Cell] The authors showed that leptin regulated appetite and body weight via prepronociceptin (PNOC) neurons, and that loss of leptin receptor expression in PNOC-expressing neurons in the arcuate nucleus of the hypothalamus caused hyperphagia and obesity.

Subcellular Functions of Tau Mediate Repair Response and Synaptic Homeostasis in Injury

April 23, 2025

[Molecular Psychiatry] Investigators identified that microtubule-associated tau was a critical player in neuronal injury response via compartmentalized functions in both repair-centric and synaptic regulatory pathways.

Pkd2l1 Deletion Inhibits the Neurogenesis of Cerebrospinal Fluid-Contacting Neurons and Impedes Spinal Cord Injury Repair

April 23, 2025

[Cell Death Discovery] Researchers utilized a Pkd2l1^−/− transgenic mouse model to investigate the role of cerebrospinal fluid-contacting neurons in spinal cord injury repair.

FDA Grants Breakthrough Therapy Designation for BrainChild Bio’s B7-H3 CAR T Cell Therapy for Incurable Pediatric Brain Tumors

April 23, 2025

[BrainChild Bio, Inc] BrainChild Bio, Inc. announced that the investigational B7-H3 targeting autologous CAR T cell therapy has been granted Breakthrough Therapy designation by the US FDA for the treatment of diffuse intrinsic pontine glioma.

Tailoring MAPK Pathways: New Therapeutic Avenues for Treating Alzheimer’s Disease

April 21, 2025

[Molecular Neurobiology] Investigators focus on MAPK-based interventions as an upcoming and innovative approach for alleviating Alzheimer's disease, with a special emphasis on clinical studies.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.