Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Hypoxia-Induced HMGB1 Promotes Glioma Stem Cells Self-Renewal and Tumorigenicity via RAGE

[iScience] Investigators reported that HMGB1 was overexpressed in human glioblastoma specimens. Hypoxia promoted the expression and secretion of HMGB1 in glioma stem cells

Loss of Function of OTUD7A in the Schizophrenia- Associated 15q13.3 Deletion Impairs Synapse Development and Function in Human Neurons

[American Journal of Human Genetics] To tie OTU deubiquitinase 7A (OTUD7A) loss-of-function (LoF) with any schizophrenia-relevant cellular phenotypes, scientists modeled the OTUD7A LoF mutation, rs757148409, in human induced pluripotent stem cell (hiPSC)-derived induced excitatory neurons (iNs) by CRISPR-Cas9 engineering.

Direct Visualization of the Transition Status during Neural Differentiation by Dual-Fluorescent Reporter Human Pluripotent Stem Cells

[Stem Cell Reports] Investigators induced the differentiation of cortical neurons from dual-reporter human iPSCs, successfully visualizing cell-fate conversion in 2D culture and 3D organoids.

An Inhibitory Brainstem Input to Dopamine Neurons Encodes Nicotine Aversion

[Neuron] The authors demonstrated that high doses of nicotine, which induced aversion-related behavior in mice, cause biphasic inhibitory and excitatory responses in VTA dopamine neurons that could be dissociated by distinct projections to lateral and medial nucleus accumben subregions, respectively.

Postmitotic Accumulation of Histone Variant H3.3 in New Cortical Neurons Establishes Neuronal Chromatin, Transcriptome, and Identity

[Proceedings of the National Academy of Sciences of the United States of America] Scientists found that during a critical developmental window for establishing postmitotic neuronal identity, newly generated cortical excitatory neurons substantially accumulate the histone H3 variant H3.3.

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

[Cell Stem Cell] Scientists employed CRISPR-edited induced pluripotent stem cells to dissect the impact of apolipoprotein E4 in neuron-microglia communication.

Label-Free Three-Photon Imaging of Intact Human Cerebral Organoids for Tracking Early Events in Brain Development and Deficits in Rett Syndrome

[eLife] The authors demonstrated label-free three-photon imaging of whole, uncleared intact organoids to assess early events of early human brain development.

Relationships between Genome-Wide R-loop Distribution and Classes of Recurrent DNA Breaks in Neural Stem/Progenitor Cells

[Scientific Reports] Researchers found that R-loops in neural stem/progenitor cells undergoing mild replication stress are present primarily in early-replicating, transcribed regions and in genes with promoter GC skewed that wereassociated with cell lineage-specific processes.

Neuroprotection of NSC Therapy is Superior to Glibenclamide in Cardiac Arrest-Induced Brain Injury via Neuroinflammation Regulation

[Translational Stroke Research] The authors evaluated and compared the therapeutic effects of neural stem cell (NSC) and glibenclamide (GBC) therapies post-cardiac arrest. In in vitro studies, BV2 cells underwent oxygen–glucose deprivation for three hours and were then treated with GBC or co-cultured with human NSCs.

Understanding Immune-Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform

[Advanced Science] The authors reported the development of a human brain organoid microphysiological analysis platform to discover the dynamic process of immune-driven brain aging.

UF Brain Cancer Researcher Awarded St. Baldrick’s Foundation Grant

[University of Florida Health] University of Florida (UF) brain cancer researcher Dr. Lan Hoang-Minh has been awarded a $100,000 grant from the St. Baldrick’s Foundation for a preclinical research project seeking to advance adoptive T cell therapy for pediatric brain tumors.

SDC1-Dependent TGM2 Determines Radiosensitivity in Glioblastoma by Coordinating EPG5-Mediated Fusion of Autophagosomes with Lysosomes

[Autophagy] It was found that SDC1 and TGM2 proteins were overexpressed in radioresistant glioblastoma cells and tissues and they contributed to the poor prognosis of radiotherapy.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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