Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Neural Stem Cell Quiescence and Activation Dynamics Are Regulated by Feedback Input from Their Progeny under Homeostatic and Regenerative Conditions

[Cell Stem Cell] In the mouse adult subventricular NSC niche, researchers charted a precise spatiotemporal map of functional responses in NSCs induced by multiple niche cells and used machine learning to predict NSC interactions with specific niche cell types.

Hijacking of the Nervous System in Cancer: Mechanism and Therapeutic Targets

[Molecular Cancer] The authors consolidate the current understanding of neuro-oncological regulation, underscoring the nuanced interplay between neurological and oncological processes

Early Spinal Cord Development: From Neural Tube Formation to Neurogenesis

[Nature Reviews Neuroscience] A rich history of observational and functional studies across various vertebrate models has advanced our understanding of the cellular events underlying spinal cord development, and these foundational studies are beginning to inform our knowledge of human spinal cord development.

A Comprehensive Spatio-Cellular Map of the Human Hypothalamus

[Nature] Investigators combined single-nucleus sequencing of 433,369 human hypothalamic cells with spatial transcriptomics, generating a comprehensive spatio-cellular transcriptional map of the hypothalamus, the ‘HYPOMAP’.

Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases

[Signal Transduction and Targeted Therapy] The research history and milestone events of studying metal ions in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, ALS, and Huntington’s disease, is introduced.

Mettl3-m6A-NPY Axis Governing Neuron–Microglia Interaction Regulates Sleep Amount of Mice

[Cell Discovery] Investigators showed that the deficiency of RNA N6-methyladenosine (m6A) methyltransferase Mettl3 in excitatory neurons specifically induced microglia activation, neuroinflammation, and neuronal loss in thalamus of mice.

FKBP5 Inhibition Ameliorates Neurodegeneration and Motor Dysfunction in the Neuromelanin-SNCA Mouse Model of Parkinson’s Disease

[Molecular Therapy] To investigate the roles of neuromelanin (NM) and α-syn in dopaminergic neuron degeneration, the authors modeled Parkinson's disease by inducing NM accumulation in a humanized α-syn mouse model via the expression of human tyrosinase in the substantia nigra.

Suppressing Recurrence in Sonic Hedgehog Subgroup Medulloblastoma Using the OLIG2 Inhibitor CT-179

[Nature Communications] Researchers investigated the therapeutic potential of the brain-penetrant orally bioavailable, OLIG2 inhibitor CT-179, using Sonic Hedgehog (SHH)- medulloblastoma (MB) explant organoids, patient-derived xenograft, and a genetically-engineered mouse SHH-MB models.

OLIG2 Mediates a Rare Targetable Stem Cell Fate Transition in Sonic Hedgehog Medulloblastoma

[Nature Communications] Integrating gene expression and chromatin accessibility patterns in distinct cellular compartments, scientists identified the transcription factor Olig2 as regulating the stem cell fate transition from quiescence to activation.

Dopaminergic Deficits along the Spectrum of Alzheimer’s Disease

[Molecular Psychiatry] Scientists investigated in vivo the pattern of dopaminergic changes and connectivity using DAT-SPECT imaging in patients across the Alzheimer's disease spectrum.

Corticosteroid-Dependent Association between Prognostic Peripheral Blood Cell-Free DNA Levels and Neutrophil-Mediated NETosis in Patients with Glioblastoma

[Clinical Cancer Research] Scientists prospectively enrolled 129 patients with treatment-naïve glioblastoma with blood drawn prior to initial resection and at time of first post-radiotherapy MRI.

Oligodendrocyte Precursor Cells Facilitate Neuronal Lysosome Release

[Nature Communications] The authors showed that oligodendrocyte precursor cells formed contacts with their processes on neuronal somata in a neuronal activity-dependent manner.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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