Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

The Neurobiology of SARS-CoV-2 Infection

[Nature Reviews Neuroscience] The authors put special emphasis on discussing the methodological difficulties of viral detection in central nervous system (CNS) tissue and discuss immune-based effects contributing to COVID-19-related CNS affection.

Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient Treatments

[EMBO Molecular Medicine] Researchers presented a protocol that enabled efficient generation, expansion, and biobanking of pediatric brain cancer organoids.

Telomere Shortening Induces Aging-Associated Phenotypes in hiPSC-Derived Neurons and Astrocytes

[Biogerontology] Investigators explored the possibility of inducing aging-associated features in cell types of the central nervous system using hiPSC technology.

Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma

[Journal Of Neuroscience] The authors reported using human tumor specimens and primary spheroids from male and female patients that GlialCAM, was differentially expressed in subpopulations of glioblastoma cells.

Germline PTEN Genotype-Dependent Phenotypic Divergence During the Early Neural Developmental Process of Forebrain Organoids

[Molecular Psychiatry] Investigators showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.

Functional Brain Region-Specific Neural Spheroids for Modeling Neurological Diseases and Therapeutics Screening

[Communications Biology] Scientists described a method for generating functional neural spheroids by cell-aggregation of differentiated human iPSC-derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain.

INPP5D Regulates Inflammasome Activation in Human Microglia

[Nature Communications] Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, the authors found that reduction in INPP5D activity was associated with molecular profiles consistent with disrupted autophagy and inflammasome activation.

CerS6-Dependent Ceramide Synthesis in Hypothalamic Neurons Promotes ER/Mitochondrial Stress and Impairs Glucose Homeostasis in Obese Mice

[Nature Communications] Scientists found increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neurons exposed to palmitate in vitro and in the hypothalamus of obese mice.

Temporal Morphogen Gradient-Driven Neural Induction Shapes Single Expanded Neuroepithelium Brain Organoids with Enhanced Cortical Identity

[Nature Communications] Scientists showed that initiating neural induction in a temporal stepwise gradient guided the generation of brain organoids composed of a single, self-organized apical-out neuroepithelium.

Tauroursodeoxycholic Acid Inhibited Apoptosis and Oxidative Stress in H2O2-Induced BMSC Death via Modulating the Nrf-2 Signaling Pathway: The Therapeutic Implications in a Rat Model...

[Molecular Neurobiology] Researchers studied the possible benefits of combining tauroursodeoxycholic acid with bone marrow MSC transplantation using an animal model of spinal cord injury.

Functional Engineering of Human iPSC-Derived Parasympathetic Neurons Enhances Responsiveness to Gastrointestinal Hormones

[FEBS Open Bio] Researchers focused on the receptors of five gastrointestinal hormones, and established human iPSC lines that functionally expressed each receptor.

BRG1 Enhances Porcine iPSC Pluripotency Through WNT/β-Catenin and Autophagy Pathways

[Theriogenology] The mechanism was investigated by regulating the WNT/β-catenin signaling pathway and autophagy flux. The results showed that inhibition of BRG1 decreased pluripotency-related gene expression in porcine iPSCs

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.