Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Tenax Announces Issuance of U.S. Patent Covering Use of IV Levosimendan in Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)

[Tenax Therapeutics, Inc.] Tenax Therapeutics, Inc. announced that the company has been issued a patent by the United States Patent and Trademark Office with claims covering the use of IV levosimendan in the treatment of pulmonary hypertension associated with HFpEF.

An Update in Club Cell Biology and Its Potential Relevance to Chronic Obstructive Pulmonary Disease

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Investigators integrate findings from scRNA-seq experiments with earlier in vitro, in vivo, and microscopy studies and highlight the many ways club cells contribute to airway homeostasis.

IGFBP5 Is an ROR1 Ligand Promoting Glioblastoma Invasion via ROR1/HER2-CREB Signaling Axis

[Nature Communications] Researchers reported Insulin-like Growth Factor-Binding Protein 5 (IGFBP5), a ligand for Receptor tyrosine kinase like Orphan Receptor 1 (ROR1), as a promising target for glioblastoma stem-like cell invasion.

SREBP2 Maintains Glioblastoma Stem Cells through Keeping the Balance between Cholesterol Biosynthesis and Uptake

[Neuro-Oncology] In vitro and in vivo loss-of-function genetic and pharmacologic assays were conducted to evaluate the effect of Sterol Regulatory Element-Binding Protein 2 (SREBP2) on glioblastomas cholesterol biosynthesis, proliferation, and self-renewal.

Spatial Epigenome–Transcriptome Co-profiling of Mammalian Tissues

[Nature] To further investigate the epigenetic mechanisms underlying gene expression regulation, scientists developed spatially resolved, genome-wide comapping of the epigenome and transcriptome by simultaneous profiling of chromatin accessibility and messenger RNA expression, or histone modifications and mRNA expression on the same tissue section at the cellular level via deterministic cobarcoding.

Purification and Characterization of Human Neural Stem and Progenitor Cells

[Cell] Researchers described a method for prospectively isolating ten distinct neural stem and progenitor cell types from the developing human brain using cell-surface markers.

Mechanism of STMN2 Cryptic Splice-Polyadenylation and Its Correction for TDP-43 Proteinopathies

[Science] Scientists determined that TDP-43 binding in the first intron of the STMN2 pre-mRNA sterically blocked access of RNA processing factors that would otherwise recognize and use a cryptic 3′ splice site.

Upregulation of SYNGAP1 Expression in Mice and Human Neurons by Redirecting Alternative Splicing

[Neuron] Investigators characterized an alternative 3′ splice site (A3SS) of SYNGAP1 that induced nonsense-mediated mRNA decay in mouse and human neural development. They demonstrated that PTBP1/2 directly bound to and promoted SYNGAP1 A3SS inclusion.

Cellular Mechanisms of Heterogeneity in NF2-Mutant Schwannoma

[Nature Communications] Researchers found that loss of the membrane:cytoskeleton-associated NF2 tumor suppressor, merlin, yields unstable intrinsic polarity and enables Nf2-/- Schwann cells to adopt distinct programs of ErbB ligand production and polarized signaling, suggesting a self-generated model of schwannoma heterogeneity.

Quinolinate Promotes Macrophage-Induced Immune Tolerance in Glioblastoma through the NMDAR/PPARγ Signaling Axis

[Nature Communications] Using global metabolomic profiling of patient-derived brain tumors, investigators identified the downstream metabolism of tryptophan and accumulation of quinolinate as a metabolic node in glioblastoma and demonstrate its critical role in promoting immune tolerance.

HSV-1 Cellular Model Reveals Links between Aggresome Formation and Early Step of Alzheimer’s Disease

[Translational Psychiatry] Using neuronal cells expressing the wild type form of amyloid precursor protein infected by HSV-1, scientists characterized a representative cellular model of the early stage of the sporadic form of the disease and unraveled a molecular mechanism sustaining this HSV-1- Alzheimer’s disease interplay.

iPSC-Derived Neural Precursor Cells Engineering GBA1 Recovers Acid β-Glucosidase Deficiency and Diminishes α-Synuclein and Neuropathology

[Molecular Therapy-Methods & Clinical Development] Researchers evaluated a cell therapy treatment using mouse-induced pluripotent stem cell-derived neural precursor cells engineered to overexpress lysosomal acid β-glucosidase.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.