Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Traumatic Brain Injury Promotes Neurogenesis at the Cost of Astrogliogenesis in the Adult Hippocampus of Male Mice

[Nature Communications] Using a controlled cortical impact model of traumatic brain injury (TBI) in male mice, single cell RNA sequencing, and spatial transcriptomics, the authors assessed how TBI affected hippocampal neural stem cells and the neuronal and astroglial lineages derived from them.

Deficient Brain GABA Metabolism Leads to Widespread Impairments of Astrocyte and Oligodendrocyte Function

[Glia] Researchers performed an untargeted integrative analysis of cerebral protein expression, functional metabolism, and lipid composition in a genetic mouse model of succinic semialdehyde dehydrogenase deficiency.

Gephyrin Promotes Autonomous Assembly and Synaptic Localization of GABAergic Postsynaptic Components without Presynaptic GABA Release

[Proceedings of The National Academy of Sciences of The United States of America] Researchers monitored the cellular distribution of several γ-aminobutyric acid (GABA)ergic postsynaptic proteins in a purely glutamatergic neuronal culture derived from human stem cells, which virtually lacked any vesicular GABA release.

CaMKII Autophosphorylation Is the Only Enzymatic Event Required for Synaptic Memory

[Proceedings of The National Academy of Sciences of The United States of America] The authors designed a series of experiments to define the minimal requirements for the synaptic enhancement by Ca2+/calmodulin-dependent kinase II (CaMKII).

Fear Learning Induces Synaptic Potentiation between Engram Neurons in the Rat Lateral Amygdala

[Nature Neuroscience] Using ex vivo 12-patch-clamp and in vivo 32-electrode electrophysiological recordings in the lateral amygdala (LA) of fear-conditioned rats, in combination with activity-dependent fluorescent and optogenetic tagging and recall, researchers identified a sparsely connected network between principal LA neurons that was organized in clusters.

$2.9M Research Grant Funds Technology for MS Stem Cell Therapy

[Multiple Sclerosis News Today] The National Institute of Neurological Disorders and Stroke has awarded a $2.9 million, five-year grant to a research project that aims to advance a new technology that could improve stem cell therapies for multiple sclerosis (MS) and other neurological disorders.

Pharmacological Modulation of Developmental and Synaptic Phenotypes in Human SHANK3 Deficient Stem Cell-Derived Neuronal Models

[Translational Psychiatry] The authors demonstrated that small molecular compounds that reversed developmental phenotypes could be identified in human neuronal Phelan-McDermid syndrome models.

Perisynaptic Schwann Cells: Guardians of Neuromuscular Junction Integrity and Function in Health and Disease

[Cold Spring Harbor Perspectives In Biology] Perisynaptic Schwann cells regulate synaptic efficacy and structural plasticity of the neuromuscular junction in a dynamic, bidirectional manner owing to their ability to decode synaptic transmission and by their interactions with trophic-related factors.

Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease

[Acta Neuropathologica] Scientists examined cerebrospinal fluid (CSF) levels of Β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) and its cleaved product sAPPβ that reflected BACE1 activity in the China Aging and Neurodegenerative Disorder Initiative cohort.

Kisspeptin Signaling in Astrocytes Modulates the Reproductive Axis

[Journal of Clinical Investigation] Researchers disclosed a pathway for direct kisspeptin actions in astrocytes that contributed to central reproductive modulation.

ADAMTS2 Promotes Radial Migration by Activating TGF-β Signaling in the Developing Neocortex

[EMBO Reports] The authors investigated the role of the extracellular matrix (ECM) at the subplate (SP) layer. They showed that TGF-β signaling-related ECM proteins, and their downstream effector, p-smad2/3, were selectively expressed in the SP layer.

Developmental Origin of Oligodendrocytes Determines Their Function in the Adult Brain

[Nature Neuroscience] Using a genetic strategy to ablate dorsally derived oligodendrocyte lineage cells (OLCs), researchers showed that the areas in which dorsally derived OLCs normally resided in the adult central nervous system became populated and myelinated by OLCs of ventral origin.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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