Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Mechanism of RIP2 Enhancing Stemness of Glioma Cells Induces Temozolomide Resistance.

[CNS Neuroscience & Therapeutics] Cancer stemness of glioma cells was investigated by sphere formation assays, clone formation assays, and xenograft tumor formation assays. The expression of RIP2, p-NF-κB, IκBα, CD133, or SOX-2 was detected by Western blotting and immunofluorescence.

Alternative RNA Splicing Modulates Ribosomal Composition and Determines the Spatial Phenotype of Glioblastoma Cells

[Nature Cell Biology] Scientists found that the compositions of ribosomes of glioblastoma cells in the tumour core and edge differed due to alternative RNA splicing. The acidic pH in the core switched before messenger RNA splicing of the ribosomal gene RPL22L1 towards the RPL22L1b isoform.

Atypical Induction of HIF-1α Expression by Pericellular Notch1 Signaling Suffices for the Malignancy of Glioblastoma Multiforme Cells

[Cellular and Molecular Life Sciences] The expression of HIF-1α was significantly elevated in highly dense glioblastoma cells, even under non-hypoxic conditions. Atypical HIF-1α expression was associated with the Notch1 signaling pathway in both glioblastoma and glioblastoma stem cells.

Alzamend Neuro Announces Addition of Healthy Subjects to Ongoing Phase IIA Clinical Trial for AL001 in Alzheimer’s Subjects

[Alzamend Neuro, Inc.] Alzamend Neuro, Inc. announced it has dosed its first healthy adult subject in its Phase IIA multiple ascending dose study of AL001 in subjects with dementia related to Alzheimer’s.

Engineered Extracellular Vesicles with SHP2 High Expression Promote Mitophagy for Alzheimer’s Disease Treatment

[Advanced Materials] Scientists developed a platform for Alzheimer's disease therapy using nanosized mesenchymal stem cells-derived extracellular vesicles with tyrosine phosphatase-2 (SHP2) high-expression.

Neurogenesis Is Disrupted in Human Hippocampal Progenitor Cells upon Exposure to Serum Samples from Hospitalized COVID-19 Patients with Neurological Symptoms

[Molecular Psychiatry] As the first-ever study conducted to test the direct effects of serum from hospitalised COVID-19 patients on human hippocampal neurogenesis, researchers utilized a unique in vitro experimental assay with human hippocampal progenitor cells.

TET3 Epigenetically Controls Feeding and Stress Response Behaviors via AGRP Neurons

[Journal of Clinical Investigation] Investigators reported that in adult mouse AGRP neurons, CRISPR-mediated genetic ablation of Tet3, not previously known to be involved in central control of appetite and metabolism, induced hyperphagia, obesity, and diabetes, in addition to a reduction of stress-like behaviors.

Developmental Dynamics of RNA Translation in the Human Brain

[Nature Neuroscience] The authors characterized the translational regulation of annotated open reading frames (ORFs) and identified thousands of previously unknown translation events, including small ORFs that gave rise to human-specific and/or brain-specific microproteins, many of which we independently verified using proteomics.

How Mechanisms of Stem Cell Polarity Shape the Human Cerebral Cortex

[Nature Reviews Neuroscience] Studies exploring how cortical stem cell polarity is established and maintained are key for understanding the features of human brain development and have implications for neurological dysfunction.

Insights from Multi-Omics Integration in Complex Disease Primary Tissues

[Trends in Genetics] By highlighting recent integrative multi-omics studies in relevant tissues of four distinct complex diseases (type 2 diabetes, osteoarthritis, Alzheimer’s disease, and systemic lupus erythematosus), investigators outline the usefulness of this approach.

Pancreatic Cancer Researcher Earns NIH Honor

[Rush University] The National Institutes of Health (NIH) has honored RUSH physician scientist Faraz Bishehsari with the Director’s Transformative Research Award, which includes funding for his innovative pancreatic cancer research.

Astrocytic NDRG2-PPM1A Interaction Exacerbates Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage

[Science Advances] Astrocytic Ndrg2 knockout decreased the phosphorylation of Smad2/3 and the transcription of MMP-9.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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