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Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
POU3F2 Regulates Canonical Wnt Signaling via SOX13 and ADNP to Expand the Neural Progenitor Population
[Brain] To elucidate the mechanistic role of POU3F2 in human neurodevelopment, scientists induced POU3F2 disruption in human neural progenitor cells
The Cell-Surface Shared Proteome of Astrocytes and Neurons and the Molecular Foundations of Their Multicellular Interactions
[Neuron] Researchers identified and mapped striatal astrocytic and neuronal cell-surface proteins and found that many were shared, representing the cell-surface shared proteome of astrocytes and neurons bridging striatal astrocyte-neuron interaction sites.
Disrupted Diencephalon Development and Neuropeptidergic Pathways in Zebrafish with Autism-Risk Mutations
[Proceedings of The National Academy of Sciences of The United States of America] Scientists defined the functional and molecular outcomes of mutating orthologs of 17 genes that increase risk for autism spectrum disorder.
Glucose Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer
[Molecular Psychiatry] Researchers established a mouse model in which mtDNA depletion is induced by the Herpes Simplex Virus Type 1 protein UL12.5 in the brain led to an epileptic phenotype, characterized by abnormal electroencephalography patterns and increased neural excitability in hippocampus.
Role of LIMK1-Cofilin-Actin Axis in Dendritic Spine Dynamics in Alzheimer’s Disease
[Cell Death & Disease] The authors synthesize current findings on Lin-11/Isl-1/Mec-3 domain-containing protein kinase 1 (LIMK1)-cofilin-actin signaling in Alzheimer's disease, emphasizing the dual role of cofilin in stabilizing and severing actin filaments.
Nociceptor-Specific Signaling of the Receptor Guanylyl Cyclase Npr2 Contributes to Acute and Persistent Pain
[Science Signaling] Researchers investigated the role of production of cyclic GMP by Npr2 in pain processing. Adult mice with a deletion of Npr2 specifically in nociceptive sensory neurons exhibit deficits in noxious heat sensing, which can activate the nonselective cation channels TRPV1 and TRPA1.
CurePSP Awards Student Fellowship Grants, Supporting Student Research in the Field
[CurePSP, Inc. (PR Newswire)] CurePSP has announced student fellowship recipients, totaling nine projects between the Urso Student Fellowship Grant and the Jim Atwood Neuroscience Student Fellowship Grant, awarded to projects that hope to answer questions advancing our understanding of progressive supranuclear palsy, corticobasal degeneration, and related diseases.
MindImmune Awarded Grant to Accelerate IND-Enabling Studies through Rhode Island Life Science Hub
[MindImmune Therapeutics (PR Newswire)] MindImmune Therapeutics announced it has been awarded a grant by Rhode Island Life Science Hub to accelerate the company’s preclinical development work on MITI-101. MITI-101 is under development for the treatment of mild-to-moderate Alzheimer’s disease.
Infrequent Strong Connections Constrain Connectomic Predictions of Neuronal Function
[Cell] Scientists characterized the visual responses of 43 cell types in the fruit fly and quantitatively compared them with connectomic predictions.
Neuron-Targeted Caveolin-1 Overexpression Attenuates Cognitive Loss and Pathological Transcriptome Changes in Symptomatic Alzheimer’s Disease Models
[Signal Transduction and Targeted Therapy] Researchers investigated the effect of hippocampal SynCav1 delivery at symptomatic age in two distinct preclinical Alzheimer's disease models of amyloid pathology: PSAPP and APPKI mice.
Dynamic Basal Ganglia Output Signals License and Suppress Forelimb Movements
[Nature] Investigators showed that basal ganglia output neurons in the mouse substantia nigra pars reticulata represent complex forelimb movements with highly granular and dynamic changes in spiking activity, tiling task execution at the population level.
Astrocyte Morphogenesis Requires Self-Recognition
[Nature] The authors reported that γC3, a specific isoform in the Pcdhγ family, is enriched in human and mouse astrocytes. Using genetic manipulation, they demonstrated that γC3 acts autonomously to regulate astrocyte morphogenesis in the mouse visual cortex.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
