Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Subscribe|Follow Us On

Xin Jin Receives Prestigious Sloan Research Fellowship

March 4, 2026

[Scripps Research] Dr. Xin Jin, an associate professor at Scripps Research and a Freeman Hrabowski Scholar at Howard Hughes Medical Institute, has been awarded a Sloan Research Fellowship for her exceptional research and leadership in the field of neuroscience.

Efficient amyloid-β Degradation in Alzheimer’s Disease Using SPYTACs

March 4, 2026

[Cell] Scientists developed a next-generation extracellular targeted protein degradation platform, synthetic peptide-programmed lysosome-targeting chimeras (SPYTACs), using entirely synthesized bispecific peptides.

ACSS2 Maintains Oligodendrocyte Progenitor Cell Pool and Is Required for Myelination during Development and Aging

March 4, 2026

[Nature Aging] Researchers observed a marked decline in the number of oligodendrocyte progenitor cells during aging, notably within the subpopulation highly expressing Acss2, which encodes acetyl-CoA synthetase 2 (ACSS2).

mtDNA Leakage Promotes Neuron-Glia Crosstalk to Induce Epilepsy by cGAS-STING-Driven Neuroinflammation and Serine Metabolic Reprogramming

March 4, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that mitochondrial DNA leakage activates microglial immune signaling, which drives astrocytes into a hypermetabolic state and increases L-serine production.

Neuronal TDP-43 Regulates Myelin Formation via Neurexin 1 mRNA Stabilization

March 4, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that loss of TAR DNA-binding protein 43 (TDP-43) in neurons induces hypomyelination, and this impairment was rescued with the supplementation of cytoplasmic TDP-43 in neurons.

β-Asarone Mediates the Alleviation of Neuroinflammation in Alzheimer’s Disease via Modulation of the TREM2/PI3K/AKT Signaling Pathway

March 4, 2026

[Inflammation] The authors investigated the therapeutic potential and mechanism of action of the natural compound β-asarone in Alzheimer’s disease (AD) models. They elucidated that β-asarone ameliorates AD pathology by modulating microglial polarization.

Effect of 6-Hydroxydopamine on Iron Metabolism in MO3.13 Oligodendrocytes

March 4, 2026

[Neurochemical Research] Researchers examined how 6-hydroxydopamine (6-OHDA) affects iron homeostasis and inflammatory gene expression in MO3.13 oligodendrocytes. They demonstrated that 6-OHDA promotes iron accumulation in undifferentiated oligodendrocytes.

Cancer Neuroscience: Signaling Pathways and New Therapeutic Strategies for Cancer

March 4, 2026

[Signal Transduction and Targeted Therapy] From the perspective of cancer neuroscience, scientists fully discuss the potential signaling molecules and their regulatory mechanisms, as well as targets and emerging therapeutic strategies that control tumor progression via multiomics approaches.

Mitochondria Transfer in Glioblastoma

March 4, 2026

[Neuro-Oncology] The authors summarize current knowledge on mitochondrial exchange in glioblastoma via tunneling nanotubes, tumor microtubes, and potentially via extracellular vesicles.

Decoding Myeloid Heterogeneity in Glioblastoma: Spatial Insights from Transcriptomics

March 4, 2026

[Journal of Translational Medicine] Investigators synthesizes emerging insights from single-cell and spatial transcriptomics to decode myeloid dynamics across distinct glioblastoma anatomical compartments.

VectorY Therapeutics Announces First Participant Dosed in Phase 1/2 PIONEER-ALS Clinical Trial of VTx-002 in People with Amyotrophic Lateral Sclerosis (ALS)

February 17, 2026

[VectorY Therapeutics] VectorY Therapeutics announced that the first participant has been dosed in its Phase 1/2 PIONEER-ALS trial evaluating VTx-002, a first-in-class vectorized antibody targeting TDP-43 pathology in people with ALS.

Glucosylceramide-Induced Ectosomes Propagate Pathogenic α-synuclein in Parkinson’s Disease

February 17, 2026

[Nature Cell Biology] Investigators used live-cell microscopy to examine the impact of Parkinson’s disease associated lipid alterations on α-synuclein release. They discovered that increased glucosylceramides as a consequence of reduced β-glucocerebrosidase activity induce ectosome shedding from primary neurons.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.