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Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Monocyte-Derived IL-6 Programs Microglia to Rebuild Damaged Brain Vasculature
[Nature Immunology] Cerebrovascular repair did not occur in interluekin (IL)-6 knockouts or in mice lacking microglial IL-6Ra expression, and single-cell transcriptomic analyses revealed faulty repair-associated microglia programming in the absence of IL-6 signaling.
Vascularized Human Brain Organoid On-Chip
[Lab On A Chip] The authors elaborate on different strategies to improve the vascularized human brain organoid microenvironment using microfluidic devices, while discussing the current obstacles and future directions in this field.
Advances and Applications of Brain Organoids
[Neuroscience Bulletin] Scientists summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors.
SPAC Takes Anew Path, Pivoting From Energy Storage To Merge With Alzheimer’s Gene Therapy Biotech
[Fierce Biotech] By merging with a blank check company, Anew Medical plans to land a Nasdaq listing and $54 million in cash to fund the development of its neurodegenerative disease gene therapies, provided investors don’t pull their money before the deal closes.
Molecular basis of FAAH-OUT-associated human pain insensitivity
[Brain] Researchers reported how the recently discovered brain and dorsal root ganglia-expressed FAAH-OUT long non-coding RNA gene regulates the adjacent key endocannabinoid system gene FAAH, which encodes the anandamide-degrading fatty acid amide hydrolase enzyme.
Cerebral Organoids Transplantation Repairs Infarcted Cortex and Restores Impaired Function After Stroke
[NPJ Regenerative Medicine] Scientists cultured human cerebral organoids derived from human pluripotent stem cells and transplanted them into the junction of the infarct core and the peri-infarct zone of NOD-SCID mice subjected to stroke.
The DRD2 Antagonist Haloperidol Mediates Autophagy-Induced Ferroptosis To Increase Temozolomide Sensitivity by Promoting Endoplasmic Reticulum Stress in Glioblastoma
[Clinical Cancer Research] Researchers determined a critical drug that causes ferroptosis in glioblastoma cells and elucidated the possible mechanism by which drug combinations overcome chemoresistance.
Oligodendrocytes in Human Induced Pluripotent Stem Cell-Derived Cortical Grafts Remyelinate Adult Rat and Human Cortical Neurons
[Stem Cell Reports] Scientists demonstrated the in vitro and in vivo production of myelinating oligodendrocytes from a human-induced pluripotent stem cell-derived long-term neuroepithelial stem cell line, which also gave rise to neurons with the capacity to integrate into stroke-injured, adult rat cortical networks.
TREM2 Expression on the Microglia Resolved Lead Exposure-Induced Neuroinflammation by Promoting Anti-Inflammatory Activities
[Ecotoxicology And Environmental Safety] Investigators showed that lead treatment significantly downregulated triggering receptor expressed on myeloid cells 2 (TREM2) expression and altered the localization of TREM2 expression in microglia.
TIPE2 Regulates the Response of BV2 Cells to Lipopolysaccharide by the Crosstalk Between PI3K/AKT Signaling and Microglia M1/M2 Polarization
[International Immunopharmacology] Researchers investigated the role and molecular mechanism of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) using a lipopolysaccharide-induced inflammatory injury model in BV2 cells.
P2X7 Receptor Antagonism by AZ10606120 Significantly Reduced In Vitro Tumour Growth in Human Glioblastoma
[Scientific Reports] Scientists reported a trophic, tumor-promoting role of P2X7R activation in both patient-derived primary glioblastoma cultures and the U251 human glioblastoma cell line, and demonstrate its inhibition reduces tumor growth in vitro.
Combination of B7H6-siRNA and Temozolomide Synergistically Reduces Stemness and Migration Properties of Glioblastoma Cancer Cells
[Experimental Cell Research] Investigators studied the potential role and molecular mechanism of the combination therapy of B7H6-siRNA and temozolomide in glioblastoma cancer.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
