Investigators reported a new brain region-specific, microglia-containing organoid model by co-culturing human PSC-derived primitive neural progenitor cells and primitive macrophage progenitors.
[Stem Cell Reports]
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Xu, R., Boreland, A. J., Li, X., Erickson, C., Jin, M., Atkins, C., Pang, Z. P., Daniels, B. P., & Jiang, P. (2021). Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.06.011 Cite
Scientists review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis.
[Journal of Experimental Medicine]
Scientists evaluated the functional activity and mechanism of TAK-243 in preclinical models of glioblastoma multiforme.
[Cell Death & Disease]
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Researchers hypothesized that elevation of cellular PpIX levels by down-regulation of MDR1 enhances anti-tumor effects by sonodynamic therapy.
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At variance with viral HCC, NAFLD-HCC shows a frequent association with cardiovascular co-morbidities, absence of cirrhosis in up to half of patients and an association with persistently normal transaminase values.
[Digestive and Liver Disease]
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Reseachers overview recent findings from human study and animal models on the pathophysiological communication among hepatocytes, Kupffer cells, hepatic stellate cells and liver sinusoidal endothelial cells during the disease development.
[Advanced Drug Delivery Reviews]
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In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.
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Bayer subsidiary BlueRock Therapeutics has been granted a fast-track review by the FDA for DA01, its stem cell-based therapy for Parkinson’s disease which is currently in early-stage clinical testing.
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Investigators determined how the microglial transcriptome was altered following modest changes to Spi1 expression in primary mouse microglia.
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An in vitro functional analysis of miR-101-3p and miR-423-5p showed that treating medulloblastoma cells with the corresponding mimics significantly inhibited the proliferation, colony-forming ability, migratory ability, and invasive capacity of tumor cells, and promoted cell apoptosis.
[Cell Death & Differentiation]
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Scientists used human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landscape in a relevant developmental context.
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