Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

UI Faculty Member Awarded Prestigious Fellowship for Neuroscience Research

[The University of Iowa] Stephanie Gantz, Carver College of Medicine assistant professor in molecular physiology and biophysics, was named one of the 2024 Sloan Research Fellows by the Alfred P. Sloan Foundation.

Dissecting the Spatiotemporal Diversity of Adult Neural Stem Cells

[Molecular Systems Biology] Scientists combined single-cell transcriptomics of dissected brain regions with massively parallel lineage tracing and in vivo RNA metabolic labeling to analyze the regulation of neural stem cells in space and time.

PP2A and GSK3 Act as Modifiers of FUS-ALS by Modulating Mitochondrial Transport

[Acta Neuropathologica] Using a genome-wide screening approach, the authors identified Protein Phosphatase 2A (PP2A) and Glycogen Synthase Kinase 3 (GSK3) as novel modifiers of fused in sarcoma-amyotrophic lateral sclerosis.

Brain-Decellularized ECM-Based 3D Myeloid Sarcoma Platform: Mimicking Adaptive Phenotypic Alterations in the Brain

[Advanced Healthcare Materials] Researchers presented a novel 3D in vitro model mimicking intracranial myeloid sarcoma, employing a hydrogel scaffold derived from the brain-decellularized extracellular matrix in which suspended leukemia cells were embedded, simulating the formation of tumor masses in the brain parenchyma.

An Animal Study on the Effectiveness of Platelet-Rich Plasma as a Direct Pulp Capping Agent

[Scientific Reports] Scientists investigated the effectiveness of Platelet Rich Plasma vs. Mineral Trioxide Aggregate as a direct pulp capping agent. 42 teeth from three mongrel dogs were divided into two equal groups.

VPS13C Regulates Phospho-Rab10-Mediated Lysosomal Function in Human Dopaminergic Neurons

[Journal of Cell Biology] Using live-cell microscopy, scientists investigated the role of vacuolar protein sorting 13 homolog C (VPS13C) in regulating lysosomal dynamics and function in human induced pluripotent stem cell-derived dopaminergic neurons.

New Rabies Viral Resources for Multi-Scale Neural Circuit Mapping

[Molecular Psychiatry] Researchers reported 20 new recombinant rabies virus vectors that they have developed for multi-scale and multi-modal neural circuit mapping tools.

A Neuron–Glia Lipid Metabolic Cycle Couples Daily Sleep to Mitochondrial Homeostasis

[Nature Neuroscience] Investigators showed that Drosophila glia exhibited a daily cycle of glial mitochondrial oxidation and lipid accumulation that was dependent on prior wake and required the Drosophila APOE orthologs NLaz and GLaz, which mediated neuron–glia lipid transfer.

Tau Depletion in Human Neurons Mitigates Aβ-Driven Toxicity

[Molecular Psychiatry] Scientists generated stable tau-depleted human induced pluripotent stem cell (iPSC) isogenic panels from two healthy individuals using CRISPR-Cas9 technology. They then differentiated these iPSCs into cortical neurons in vitro in co-culture with primary rat cortical astrocytes.

Heterogeneity and Tumoral Origin of Medulloblastoma in the Single-Cell Era

[Oncogene] The authors present an overview of the current progress in understanding of cellular heterogeneity and tumor origin of medulloblastoma and discuss novel findings in the age of single-cell technologies.

Identification of Direct Connections between the Dura and the Brain

[Nature] Using transcriptomic data, the authors developed transgenic mice to examine specific anatomical structures that function as routes across the arachnoid barrier.

New Initiative Launched to Accelerate the Use of AI in the Fight Against Neurodegenerative Diseases

[10,000 Brains Neuro AI, Inc. (PR Newswire)] The 10,000 Brains Project has been launched to promote the ethical use of artificial intelligence (AI) in the fight against Alzheimer's, Parkinson's, and other neurodegenerative diseases.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.