Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Glioblastoma-Instructed Astrocytes Suppress Tumor-Specific T Cell Immunity

May 21, 2025

[Nature] The authors used single-cell and bulk RNA sequencing of clinical glioblastoma samples and samples from preclinical models, multiplexed immunofluorescence, in vivo CRISPR-based cell-specific genetic perturbations and in vitro mouse and human experimental systems to study the role of astrocytes in the immune response to glioblastoma.

Mutations in NEK1 Cause Ciliary Dysfunction As a Novel Pathogenic Mechanism in Amyotrophic Lateral Sclerosis

May 21, 2025

[Molecular Neurodegeneration] The authors studied the genetic contribution of NIMA-related kinase 1 (NEK1) to ALS pathogenesis by analyzing the exome sequences of 920 Korean patients with ALS.

A Postsynaptic GPR158-PLCXD2 Complex Controls Spine Apparatus Abundance and Dendritic Spine Maturation

May 21, 2025

[Developmental Cell] Researchers identified a postsynaptic signaling complex comprising the G protein-coupled receptor- GPR158 and a constitutively active phospholipase C (PLC) family member, PLC X-domain containing 2 (PLCXD2), that controls spine apparatus abundance.

Stathmin-2 Enhances Motor Axon Regeneration after Injury Independent of Its Binding to Tubulin

May 21, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Scientists determined that stathmin-2 is required for functional recovery and reinnervation of neuromuscular junctions after sciatic nerve crush injury.

Physical Activity Stimulates Clock Neurons of the Day-Active Rodent Arvicanthis ansorgei

May 21, 2025

[Proceedings of The National Academy of Sciences of The United States of America] By recording from clock neurons, investigators established that physical activity leads to immediate activation of the neurons in the diurnal rodent, Arvicanthis.

Exploring the Complexity of MECP2 Function in Rett Syndrome

May 21, 2025

[Nature Reviews Neuroscience] Scientists review recent insights from epigenomic, transcriptomic, and proteomic studies that advance the understanding of MECP2 as an interacting hub for DNA, RNA, and transcription factors, orchestrating diverse processes that are crucial for neuronal function.

Filamin A in Focus: Unravelling the Multifaceted Roles of Filamin A in Neurodevelopment and Neurological Disorder

May 21, 2025

[Brain] The authors delve into filamin A’s multifaceted role in neurodevelopment, with a particular focus on its contributions to neuronal migration, dendritic and axonal growth, and mechanotransduction.

Brain Canada Invests in Six Montreal-Area Platforms to Drive Open Science Innovation

May 21, 2025

[Brain Canada] Six exceptional research platforms located in Montreal have been awarded funding through Brain Canada's Platform Support Grants program.

Astrocytic mGluR5-Dependent Calcium Hyperactivity Promotes Amyloid-β Pathology and Cognitive Impairment

May 16, 2025

[Brain] Scientists first quantified a high expression level of astrocytic mGluR5 in the hippocampus of Alzheimer’s disease brains and demonstrated that the expression of astrocytic mGluR5 was positively correlated with Alzheimer’s disease progression in both humans and mice.

Genetic Modeling of ELP1-Associated Sonic Hedgehog Medulloblastoma Identifies MDM2 As a Selective Therapeutic Target

May 16, 2025

[Cancer Cell] Genetically engineered mice mimicking heterozygous elongator acetyltransferase complex subunit 1 (Elp1) loss-of-function seen in affected germline carriers exhibit hallmark features of premalignancy in cerebellar granule neuron progenitors.

Norepinephrine Changes Behavioral State through Astroglial Purinergic Signaling

May 15, 2025

[Science] In larval zebrafish, norepinephrine triggers astroglial release of adenosine triphosphate (ATP), extracellular conversion of ATP into adenosine, and behavioral suppression through activation of hindbrain neuronal adenosine receptors.

Norepinephrine Signals through Astrocytes to Modulate Synapses

May 15, 2025

[Science] Scientists showed that norepinephrine remodeling of synaptic function is completely independent from its binding on neuronal receptors.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.