Harnessing Cerebral Organoids for Alzheimer’s Disease Research

Scientists review the most recent advances in modeling Alzheimer’s disease in organoids and other engineered 3D cell culture systems.
[Current Opinion in Neurobiology]
[zotpress userid=” items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Lixte Biotechnology Holdings, Inc. Announces That Enrollment Has Resumed in National Cancer Institute’s Trial to Determine Ability of Lixte Compound Lb-100 to Enter Recurrent, Malignant Brain Tumors

Lixte Biotechnology Holdings, Inc. announced that the National Cancer Institute has resumed enrolling patients into their pharmacologic study of the ability of Lixte’s lead compound, LB-100, to enter the brain and penetrate recurrent, malignant brain tumors, in patients where surgical removal of their cancer is indicated.
[Lixte Biotechnology Holdings, Inc.]
[zotpress userid=” items=’nan’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Transcriptome Analysis in LRRK2 and Idiopathic Parkinson’s Disease at Different Glucose Levels

To detect potential effects of different glucose levels on gene expression, by RNA-seq researchers analyzed the transcriptome of dermal fibroblasts from idiopathic Parkinson’s disease (PD) patients, LRRK2-associated PD patients, and healthy controls, cultured at two different glucose concentrations.
[npj Parkinson’s Disease]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Ligands Binding to the Prion Protein Induce Its Proteolytic Release with Therapeutic Potential in Neurodegenerative Proteinopathies

The prion protein (PrPC) is a central player in neurodegenerative diseases, such as Alzheimer’s disease. Scientists used biochemical, cell biological, and structural methods to investigate mechanisms stimulating PrPC release by the metalloprotease ADAM10.
[Science Advances]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Traumatic Brain Injury in the Presence of Aβ Pathology Affects Neuronal Survival, Glial Activation and Autophagy

The authors investigated cellular injury-induced processes in the presence of amyloid β (Aβ) pathology and exposed a co-culture system of cortical stem-cell derived astrocytes, neurons and oligodendrocytes to Aβ42 protofibrils prior to a mechanically induced scratch injury.
[Scientific Reports]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Altered Temporal Sequence of Transcriptional Regulators in the Generation of Human Cerebellar Granule Cells

Investigators reported a rapid protocol for the derivation of the human ATOH1 lineage, the precursor of excitatory cerebellar neurons, from human pluripotent stem cells.
[eLife]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Axonal TDP-43 Condensates Drive Neuromuscular Junction Disruption through Inhibition of Local Synthesis of Nuclear Encoded Mitochondrial Proteins

The authors showed TDP-43 accumulation in intra-muscular nerves from amyotrophic lateral sclerosis (ALS) patients and in axons of human iPSC-derived motor neurons of ALS patients, as well as in motor neurons and neuromuscular junctions of a TDP-43 mislocalization mouse model.
[Nature Communications]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Altered H3 Histone Acetylation Impairs High-Fidelity DNA Repair to Promote Cerebellar Degeneration in Spinocerebellar Ataxia Type 7

Scientists performed chromatic immunoprecipitation sequencing ChIP-seq on cerebellum from spinocerebellar ataxia type 7 mice and observed increased H3K9-promoter acetylation in DNA repair genes, resulting in increased expression.
[Cell Reports]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Implications of miR-148a-3p/p35/PTEN Signaling in Tau Hyperphosphorylation and Autoregulatory Feed-Forward of Akt/CREB in Alzheimer’s Disease

RNA sequencing, qRT-PCR, and Western blot analysis were used to identify the aberrant expression and signaling of miR-148a-3p within cells, mice, and patients with Alzheimer’s disease (AD). Researchers implicated the miR-148a-3p/p35/PTEN pathway as an essential contributor to tau hyperphosphorylation and feed-forward regulation in AD.
[Molecular Therapy-Nucleic Acids]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Circ-Hdgfrp3 Shuttles along Neurites and Is Trapped in Aggregates Formed by ALS-Associated Mutant FUS

Investigators defined several features of circ-Hdgfrp3 and described interesting alterations occurring in motor neurons carrying ALS-associated FUS mutations. Through a highly sensitive in situ approach they described that circ-Hdgfrp3 trafficked along neurites, whilst upon oxidative stress it was retained in the perinuclear region.
[iScience]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

AMPylation Profiling during Neuronal Differentiation Reveals Extensive Variation on Lysosomal Proteins

Through a combination of chemical proteomics, gel-based separation of modified and unmodified proteins and an activity assay, the authors determined that the modified, lysosomal soluble form of exonuclease PLD3 increased dramatically during neuronal maturation and that AMPylation correlated with its catalytic activity.
[iScience]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

Share
Share