Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

BACE-1 Inhibition Facilitates the Transition From Homeostatic Microglia to DAM-1

[Science Advances] Scientists reported that microglial BACE-1 regulates the transition of homeostatic to stage 1 disease-associated microglia (DAM-1) signature.

Spatial Centrosome Proteome of Human Neural Cells Uncovers Disease-Relevant Heterogeneity

[Science] Investigators used spatial proteomics to elucidate protein interaction networks at the centrosome of human induced pluripotent stem cell–derived neural stem cells (NSCs) and neurons.

Implementation of a Combined CDK Inhibition and Arginine-Deprivation Approach To Target Arginine-Auxotrophic Glioblastoma Multiforme Cells

[Cell Death & Disease] Three arginine-auxotrophic patient-derived Glioblastoma multiforme (GBM) lines with different molecular characteristics were cultured in 2D and 3D and effects of this combined SpyADI/CDKi approach were analyzed in-depth.

Activation of STAT3 Through Combined SRC and EGFR Signaling Drives Resistance to a Mitotic Kinesin Inhibitor in Glioblastoma

[Cell Reports] Investigators reported that in glioblastoma (GBM), resistance to the Kif11 inhibitor ispinesib works through suppression of apoptosis driven by activation of STAT3.

Targeting EP2 Receptor With Multifaceted Mechanisms for High-Risk Neuroblastoma

[Cell Reports] Researchers reported that knockout of EP2 in neuroblastoma (NB) cells blocks the development of xenografts, and its conditional knockdown prevents established tumors from progressing.

Transcriptomics Analysis of Human iPSC-Derived Dopaminergic Neurons Reveals a Novel Model for Sporadic Parkinson’s Disease

[Molecular Psychiatry] Researchers differentiated human induced pluripotent stem (iPSCs) into dopaminergic neurons, and subsequently exposed the cells to increasing concentrations of the neurotoxin MPP+.

Amyloid-β Impairs Mitochondrial Dynamics and Autophagy in Alzheimer’s Disease Experimental Models

[Scientific Reports] Scientists reported imbalances in the mitochondrial dynamics in the cerebral cortex and hippocampus of mice representing very early events in the disease progression.

Neuronal Hyperexcitability in Alzheimer’s Disease: What Are the Drivers Behind This Aberrant Phenotype?

[Translational Psychiatry] The authors discuss contributors to aberrant neuronal excitability, including abnormal levels of intracellular Ca2+ and glutamate, pathological amyloid β (Aβ) and tau, genetic risk factors, including APOE, and impaired inhibitory interneuron and glial function.

CEND1 Deficiency Induces Mitochondrial Dysfunction and Cognitive Impairment in Alzheimer’s Disease

[Cell Death & Differentiation] By proteomic analysis, scientists identified a new mitochondrial protein, cell-cycle exit and neuronal differentiation 1 (CEND1), which was decreased significantly in the brain of 5xFAD mice.

Astrocytic Urea Cycle Detoxifies Aβ-Derived Ammonia While Impairing Memory in Alzheimer’s Disease

[Cell Metabolism] Investigators reported that normal astrocytes show non-cyclic urea metabolism, whereas beta-amyloid (Aβ)-treated astrocytes show switched-on urea cycle with upregulated enzymes and accumulated entering-metabolite aspartate, starting-substrate ammonia, end-product urea, and side-product putrescine.

US FDA Awards Orphan Drug Designation (OOD) to Paxalisib for AT/RT, a Rare Form of Childhood Brain Cancer

[Kazia Therapeutics Limited] Kazia Therapeutics Limited announced that the US FDA has awarded ODD to Kazia’s paxalisib for the treatment of atypical rhabdoid / teratoid tumors, a rare and highly aggressive childhood brain cancer.

VBI Vaccines Receives US FDA Orphan Drug Designation for VBI-1901 for the Treatment of Glioblastoma

[VBI Vaccines Inc.] VBI Vaccines Inc. announced that the US FDA granted Orphan Drug Designation for VBI-1901, a bivalent gB/pp65 immunotherapeutic vaccine candidate for the treatment of glioblastoma.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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