Scientists review the most recent advances in modeling Alzheimer’s disease in organoids and other engineered 3D cell culture systems.
[Current Opinion in Neurobiology]
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Category Archives: Neural Cell
Neural Cell NewsNeural Cell News is an online publication and email newsletter covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Neural Cell News is an online publication to help scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
Harnessing Cerebral Organoids for Alzheimer’s Disease Research
Lixte Biotechnology Holdings, Inc. Announces That Enrollment Has Resumed in National Cancer Institute’s Trial to Determine Ability of Lixte Compound Lb-100 to Enter Recurrent, Malignant Brain Tumors
Lixte Biotechnology Holdings, Inc. announced that the National Cancer Institute has resumed enrolling patients into their pharmacologic study of the ability of Lixte’s lead compound, LB-100, to enter the brain and penetrate recurrent, malignant brain tumors, in patients where surgical removal of their cancer is indicated.
[Lixte Biotechnology Holdings, Inc.]
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Transcriptome Analysis in LRRK2 and Idiopathic Parkinson’s Disease at Different Glucose Levels
To detect potential effects of different glucose levels on gene expression, by RNA-seq researchers analyzed the transcriptome of dermal fibroblasts from idiopathic Parkinson’s disease (PD) patients, LRRK2-associated PD patients, and healthy controls, cultured at two different glucose concentrations.
[npj Parkinson’s Disease]
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Ligands Binding to the Prion Protein Induce Its Proteolytic Release with Therapeutic Potential in Neurodegenerative Proteinopathies
The prion protein (PrPC) is a central player in neurodegenerative diseases, such as Alzheimer’s disease. Scientists used biochemical, cell biological, and structural methods to investigate mechanisms stimulating PrPC release by the metalloprotease ADAM10.
[Science Advances]
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Traumatic Brain Injury in the Presence of Aβ Pathology Affects Neuronal Survival, Glial Activation and Autophagy
The authors investigated cellular injury-induced processes in the presence of amyloid β (Aβ) pathology and exposed a co-culture system of cortical stem-cell derived astrocytes, neurons and oligodendrocytes to Aβ42 protofibrils prior to a mechanically induced scratch injury.
[Scientific Reports]
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Altered Temporal Sequence of Transcriptional Regulators in the Generation of Human Cerebellar Granule Cells
Investigators reported a rapid protocol for the derivation of the human ATOH1 lineage, the precursor of excitatory cerebellar neurons, from human pluripotent stem cells.
[eLife]
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Axonal TDP-43 Condensates Drive Neuromuscular Junction Disruption through Inhibition of Local Synthesis of Nuclear Encoded Mitochondrial Proteins
The authors showed TDP-43 accumulation in intra-muscular nerves from amyotrophic lateral sclerosis (ALS) patients and in axons of human iPSC-derived motor neurons of ALS patients, as well as in motor neurons and neuromuscular junctions of a TDP-43 mislocalization mouse model.
[Nature Communications]
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Altered H3 Histone Acetylation Impairs High-Fidelity DNA Repair to Promote Cerebellar Degeneration in Spinocerebellar Ataxia Type 7
Scientists performed chromatic immunoprecipitation sequencing ChIP-seq on cerebellum from spinocerebellar ataxia type 7 mice and observed increased H3K9-promoter acetylation in DNA repair genes, resulting in increased expression.
[Cell Reports]
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Implications of miR-148a-3p/p35/PTEN Signaling in Tau Hyperphosphorylation and Autoregulatory Feed-Forward of Akt/CREB in Alzheimer’s Disease
RNA sequencing, qRT-PCR, and Western blot analysis were used to identify the aberrant expression and signaling of miR-148a-3p within cells, mice, and patients with Alzheimer’s disease (AD). Researchers implicated the miR-148a-3p/p35/PTEN pathway as an essential contributor to tau hyperphosphorylation and feed-forward regulation in AD.
[Molecular Therapy-Nucleic Acids]
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Circ-Hdgfrp3 Shuttles along Neurites and Is Trapped in Aggregates Formed by ALS-Associated Mutant FUS
Investigators defined several features of circ-Hdgfrp3 and described interesting alterations occurring in motor neurons carrying ALS-associated FUS mutations. Through a highly sensitive in situ approach they described that circ-Hdgfrp3 trafficked along neurites, whilst upon oxidative stress it was retained in the perinuclear region.
[iScience]
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AMPylation Profiling during Neuronal Differentiation Reveals Extensive Variation on Lysosomal Proteins
Through a combination of chemical proteomics, gel-based separation of modified and unmodified proteins and an activity assay, the authors determined that the modified, lysosomal soluble form of exonuclease PLD3 increased dramatically during neuronal maturation and that AMPylation correlated with its catalytic activity.
[iScience]
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