Antagonistic Effects of IL-17 and Astragaloside IV on Cortical Neurogenesis and Cognitive Behavior after Stroke in Adult Mice through Akt/GSK-3β Pathway

Researchers showed knocking out IL-17 contributed to regulating PI3K/Akt pathway, promoting neural stem cell proliferation, and neurogenesis after ischemic stroke.
[Cell Death Discovery]
Sun, L., Han, R., Guo, F., Chen, H., Wang, W., Chen, Z., Liu, W., Sun, X., & Gao, C. (2020). Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway. Cell Death Discovery, 6(1), 1–18. https://doi.org/10.1038/s41420-020-00298-8 Cite
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Synergy between Amyloid-β and Tau in Alzheimer’s Disease

The authors highlight the latest evidence base pertaining to the complex Aβ–tau interaction and underscore its crucial importance to elucidating disease pathogenesis and the design of next-generation Alzheimer’s disease therapeutic trials.
[Nature Neuroscience]
Busche, M. A., & Hyman, B. T. (2020). Synergy between amyloid-β and tau in Alzheimer’s disease. Nature Neuroscience, 1–11. https://doi.org/10.1038/s41593-020-0687-6 Cite
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Fabrication of Homotypic Neural Ribbons as a Multiplex Platform Optimized for Spinal Cord Delivery

Investigators encapsulated homotypic spinal cord neural stem cells in an alginate-based neural ribbon delivery platform. They performed a comprehensive in vitro analysis and qualitatively demonstrated graft survival and injury site retention using a rat C4 hemi-contusion model.
[Scientific Reports]
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Modeling SHH-Driven Medulloblastoma with Patient iPS Cell-Derived Neural Stem Cells

Investigators describe a medulloblastoma model using induced pluripotent stem cell-derived human neuroepithelial stem cells generated from a Gorlin syndrome patient carrying a germline mutation in the sonic hedgehogreceptor PTCH1.
[Proceedings of the National Academy of Sciences of the United States of America]
Susanto, E., Navarro, A. M., Zhou, L., Sundström, A., Bree, N. van, Stantic, M., Moslem, M., Tailor, J., Rietdijk, J., Zubillaga, V., Hübner, J.-M., Weishaupt, H., Wolfsberger, J., Alafuzoff, I., Nordgren, A., Magnaldo, T., Siesjö, P., Johnsen, J. I., Kool, M., … Wilhelm, M. (2020). Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1920521117 Cite
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Purine Metabolism Regulates DNA Repair and Therapy Resistance in Glioblastoma

By correlating intracellular metabolite levels with radiation resistance across dozens of genomically-distinct models of glioblastoma, researchers find that purine metabolites, especially guanylates, strongly correlate with radiation resistance.
[Nature Communications]
Zhou, W., Yao, Y., Scott, A. J., Wilder-Romans, K., Dresser, J. J., Werner, C. K., Sun, H., Pratt, D., Sajjakulnukit, P., Zhao, S. G., Davis, M., Nelson, B. S., Halbrook, C. J., Zhang, L., Gatto, F., Umemura, Y., Walker, A. K., Kachman, M., Sarkaria, J. N., … Wahl, D. R. (2020). Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nature Communications, 11(1), 3811. https://doi.org/10.1038/s41467-020-17512-x Cite
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Inhibition of miR-1193 Leads to Synthetic Lethality in Glioblastoma Multiforme Cells Deficient of DNA-PKcs

By implementing a highly efficient high-throughput screening platform using an in-house-constructed genome-wide human microRNA inhibitor library, scientists demonstrated that miR-1193 inhibition sensitized glioblastoma multiforme tumor cells with DNA-PKcs deficiency.
[Cell Death & Disease]
Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs | Cell Death & Disease. (n.d.). Retrieved August 5, 2020, from https://www.nature.com/articles/s41419-020-02812-3 Cite
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Pharmacologically Inhibiting Phosphoglycerate Kinase 1 for Glioma with NG52

Researchers developed a high-throughput screening and discovered that NG52, previously known as a yeast cell cycle-regulating kinase inhibitor, could inhibit the kinase activity of phosphoglycerate kinase 1.
[Acta Pharmacologica Sinica]
Wang, W., Jiang, Z., Hu, C., Chen, C., Hu, Z., Wang, A., Wang, L., Liu, J., Wang, W., & Liu, Q. (2020). Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacologica Sinica, 1–8. https://doi.org/10.1038/s41401-020-0465-8 Cite
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A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury

Scientists showed that notch signaling-deficient astrocytes could generate new neurons after injury. Using single-cell RNA sequencing, they found that, when notch signaling was blocked, astrocytes transitioned to a neural stem cell-like state.
[Cell Stem Cell]
Zamboni, M., Llorens-Bobadilla, E., Magnusson, J. P., & Frisén, J. (2020). A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.07.006 Cite
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Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury

The authors performed calcium imaging of neural stem/progenitor cell grafts in spinal cord injury sites in vivo and in adult spinal cord slices.
[Cell Stem Cell]
Ceto, S., Sekiguchi, K. J., Takashima, Y., Nimmerjahn, A., & Tuszynski, M. H. (2020). Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.07.007 Cite
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MODAG Successfully Completes Phase 1 Study of their Lead Candidate Anle138b and Receives Additional USD 1.4 Million from Michael J. Fox Foundation

MODAG announced the successful completion of its first clinical trial of anle138b (NCT04208152) in healthy volunteers. Based on the positive Phase I study results, MODAG was also able to obtain additional funding of USD 1.4 million from The Michael J. Fox Foundation for parkinson’s research.
[MODAG]
Press Release

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Activation of a Neural Stem Cell Transcriptional Program in Parenchymal Astrocytes

Researchers used single-cell RNA sequencing to characterize neurogenesis by notch-depleted striatal astrocytes in vivo.
[eLife]
Activation of a neural stem cell transcriptional program in parenchymal astrocytes | eLife. (n.d.). Retrieved August 5, 2020, from https://elifesciences.org/articles/59733 Cite
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Diversity and Function of Corticopetal and Corticofugal GABAergic Projection Neurons

Research conducted over the past 10 years has revealed that cortical GABAergic projection neurons are highly diverse in terms of molecular marker expression, synaptic targeting, activity pattern during distinct behavioural states and precise temporal recruitment relative to ongoing neuronal network oscillations.
[Nature Reviews Neuroscience]
Melzer, S., & Monyer, H. (2020). Diversity and function of corticopetal and corticofugal GABAergic projection neurons. Nature Reviews Neuroscience, 1–17. https://doi.org/10.1038/s41583-020-0344-9 Cite
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