Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Firefly Inks Latest Commercial Agreement for Use of Its FDA-Cleared BNA™ Platform in Groundbreaking Precision Neuroscience Research

July 16, 2025

[Firefly Neuroscience, Inc. (GlobeNewswire)] Firefly Neuroscience, Inc. highlighted its ongoing collaboration with Prof. Dr. med. Christian Schaaf on a groundbreaking study investigating the neurophysiological impact of 15q13.3 copy number variants.

Evidence for Trans-Synaptic Propagation of Oligomeric Tau in Human Progressive Supranuclear Palsy

July 16, 2025

[Nature Neuroscience] Investigators tested the hypothesis that pathological tau contributes to synapse loss and may spread through the brain by moving from presynapses to postsynapses.

Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells

July 16, 2025

[Nature Communications] Scientists explored the expression dynamics of cortical and neuropsychiatric disorder-associated genes in datasets generated from human NSCs across telencephalic fate transitions in vitro and in vivo.

The STING Pathway Drives Noninflammatory Neurodegeneration in NGLY1 Deficiency

July 16, 2025

[Journal of Experimental Medicine] The authors generated a postnatal inducible whole-body Ngly1 knockout mouse to model NGLY1 deficiency, an early-onset neurodegenerative disorder.

Cypin Regulates K63-Linked Polyubiquitination to Shape Synaptic Content

July 16, 2025

[Science Advances] Researchers reported an emerging function for the cytosolic PSD-95 interactor, cypin, in the regulation of synaptic content by K63-polyubiquitin during neuronal development in vitro and in adult mice in vivo.

Loss of Pol III Repressor Maf1 in Neurons Promotes Longevity by Preventing the Age-Related Decline in 5S rRNA and Translation

July 16, 2025

[PLOS Biology] Scientists focused on Maf1, a repressor of protein synthesis genes transcribed by RNA Polymerase (Pol) III, such as the 5S rRNA and tRNAs, and its role in aging.

Astrocytic RIPK3 Exerts Protective Anti-Inflammatory Activity in Mice with Viral Encephalitis by Transcriptional Induction of Serpins

July 16, 2025

[Science Signaling] Investigators used mouse genetic tools to induce astrocyte-specific deletion, overexpression, and chemogenetic activation of RIPK3 to demonstrate an anti-inflammatory function for astrocytic RIPK3.

Shaping the Synapse through Neuronal Activity-Regulated miRNAs

July 16, 2025

[Trends In Neurosciences] Transcriptional regulation enables neuron-wide structural adaptations, while synapse-specific transport and maturation ensure localized protein synthesis.

The Rab3 Family Proteins in Age-Related Neurodegeneration: Unraveling Molecular Pathways and Potential Therapeutic Targets

July 16, 2025

[NPJ Aging ] Scientists provide an overview of how Rab3s dysregulation disrupts neuronal homeostasis, contributing to impaired autophagy, synaptic dysfunction, and eventually leading to neuronal death.

Advances, Challenges, and Opportunities of Human Midbrain Organoids for Modelling of the Dopaminergic System

July 9, 2025

[EMBO Journal] Scientists summarize recent advances and remaining challenges in developing such human midbrain organoids from hiPSCs.

Restoration of Striatal Neuroprotective Pathways by Kinase Inhibitor Treatment of Parkinson’S Disease-Linked LRRK2-Mutant Mice

July 2, 2025

[Science Signaling] Researchers tested the leucine-rich repeat kinase 2 (LRRK2) inhibitor MLi-2 in a mouse model of early stage, LRRK2 mutation–associated Parkinson's disease.

Glial Reactivity Correlates with Synaptic Dysfunction across Aging and Alzheimer’s Disease

July 2, 2025

[Nature Communications] Scientists investigated the association between glial reactivity and synaptic dysfunction biomarkers in cerebrospinal fluid from 478 individuals in cognitively unimpaired and cognitively impaired individuals.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.