Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Atypical Chemokine Receptor 3 Regulates Synaptic Removal in Disease Astrocytes

July 22, 2026

[Molecular Neurodegeneration] Investigators demonstrated that the Atypical chemokine receptor 3 is a major player of astrocyte-mediated synapse engulfment.

AQP4-Dependent Enhancement of Glymphatic Function Attenuates Tau Pathology and Neurodegeneration in PS19 Mice

July 22, 2026

[Molecular Neurodegeneration] Researchers showed that enhancing AQP4-dependent glymphatic function reduces tau pathology and neurodegeneration, identifying glymphatic modulation as a promising therapeutic strategy for tau-related brain disorders.

MARCKS As a Mediator and Target for Pathological Tunneling Nanotubes Between Patient-Derived Glioblastoma Cells and Astrocytes

July 22, 2026

[Cell Death & Disease] The authors demonstrated a role for the Myristoylated Alanine Rich C-Kinase Substrate (MARCKS) effector domain and PKC activation in the formation and functionality of tunneling nanotubes between PTEN-null glioblastoma brain tumor–initiating cells and normal human astrocytes.

Targeting Mitotic Kinesin KIF20A: A Differentiation-Based Therapeutic Strategy for Glioblastoma Stem/Progenitor Cells

July 22, 2026

[Stem Cell Reports] Scientists investigated the therapeutic potential of targeting mitotic kinesin KIF20A in glioblastoma multiforme stem/progenitor cells.

Neuronal Differentiation of Neuroblastoma Cell Lines for Neurological Disease Modeling

July 22, 2026

[iScience] Researchers explored the potential of different neuroblastoma (NB) cell lines as neuronal models. They made in-depth molecular characterization of 18 publicly available NB cell lines, by identifying mutations in NB genes such as MYCN and ALK.

TAZ Mediates Enhancer Reprogramming Blocks Neuronal Differentiation in Glioma Stem-Like Cells

July 22, 2026

[Scientific Reports] Investigators combined in silico, in vitro, and in vivo methods to determine the influence of transcriptional coactivator with PDZ-binding motif (TAZ), an oncogenic transcription coactivator, in regulating cellular hierarchies in glioma stem-like cells.

miR-132 Overexpression Is Associated with Modulation in miR-21 Expression and Glioblastoma Cell Behavior

July 22, 2026

[PloS One] Researchers combined in silico analyses of ten independent miRNA expression datasets with functional validation in glioblastoma multiforme (GBM) cell models to investigate the association between miR-132 and miR-21 in GBM.

Alzheimer’s Disease: A Review of Molecular Mechanisms and Interventions Targeting aβ-Binding Receptors

July 22, 2026

[ACS Chemical Neuroscience] Scientists highlight how targeting Aβ-binding receptors could block toxic amyloid signaling, offering promising therapeutic strategies for Alzheimer's disease.

NWO Awards Ten Veni Grants to Promising UM Researchers

July 22, 2026

[Maastricht University] As many as ten young UM researchers have been awarded a Veni grant worth up to €320,000 from the Netherlands Organisation for Scientific Research (NWO).

Zebrafish Oligodendrocyte Lineage Cells Use the Postsynaptic Protein Gephyrin to Myelinate GABAergic Axons and Limit Myelin Sheath Growth

July 6, 2026

[Nature Communications] The authors examined whether the inhibitory postsynaptic scaffold protein Gephyrin mediates selective myelination of specific axon classes in the larval zebrafish.

Therapeutic Targeting of the Conserved Region Within the Low-Complexity Domain of TDP-43 Is Neuroprotective and Extends Survival in Amyotrophic Lateral Sclerosis Mice

July 6, 2026

[Nature Aging] Investigators showed that the conserved α-helical region spanning residues 320–340 is a therapeutically actionable target for TAR DNA-binding protein 43 (TDP-43) neurotoxicity.

Glioblastoma Stem Cell Growth Requires DOT1L-MED23 Control of Enhancer Accessibility

July 6, 2026

[Cell Reports] Scientists showed that the histone methyltransferase DOT1L shapes chromatin accessibility of glioblastoma stem cell enhancer elements to reversibly regulate fate- and growth-related transcriptional programs.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.