Neurotoxins Subvert the Allosteric Activation Mechanism of SARM1 to Induce Neuronal Loss

Investigators showed the nicotinamide analog 3-acetylpyridine, was converted to 3-APMN, which activated SARM1 and induced SARM1-dependent NAD+ depletion, axon degeneration, and neuronal death.
[Cell Reports]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

PHF3 Regulates Neuronal Gene Expression through the Pol II CTD Reader Domain SPOC

Scientists identified PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks onto Pol II CTD through its SPOC domain. Key neuronal genes were aberrantly expressed in Phf3 knock-out mouse embryonic stem cells, resulting in impaired neuronal differentiation.
[Nature Communications]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Modifying the m6A Brain Methylome by ALKBH5-Mediated Demethylation: A New Contender for Synaptic Tagging

Researchers demonstrated that at activated glutamatergic post-synaptic sites, both the YTHDF1 and YTHDF3 reader and the ALKBH5 eraser proteins increase in co-localisation to m6A-modified RNAs; but only the readers showed high co-localisation to modified RNAs during late-stage plasticity.
[Molecular Psychiatry]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Neuronal Excitatory-to-Inhibitory Balance Is Altered in Cerebral Organoid Models of Genetic Neurological Diseases

Scientists utilized no known disease/healthy cerebral organoids (COs) as normal function controls. At 3–4 and 6–10 months post-differentiation, COs with mutations showed no evidence of disease-related pathology.
[Molecular Brain]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Inhibiting Microcephaly Genes as Alternative to Microtubule Targeting Agents to Treat Brain Tumors

The genes mutated in primary hereditary microcephaly are ubiquitously expressed in proliferating cells, but under normal conditions are selectively required during brain development, in neural progenitors.
[Cell Death & Disease]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

The Presynaptic Glycine Transporter GlyT2 Is Regulated by the Hedgehog Pathway In Vitro and In Vivo

The identity of a glycinergic synapse is maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptures glycine back to presynaptic terminals to preserve vesicular glycine content. The authors identified the Hedgehog pathway as a robust controller of GlyT2 expression and transport activity.
[Communications Biology]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Hippocampal Disruptions of Synaptic and Astrocyte Metabolism Are Primary Events of Early Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer’s Disease

Scientists provided an integrative analysis of cellular metabolism during the early stages of amyloid-β accumulation in the cerebral cortex and hippocampus of the 5xFAD mouse model of Alzheimer’s disease.
[Cell Death & Disease]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Cofilin1 Oxidation Links Oxidative Distress to Mitochondrial Demise and Neuronal Cell Death

Investigators presented the role of the actin-regulating protein cofilin1 in regulating mitochondrial pathways in oxidative neuronal death.
[Cell Death & Disease]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Ciliary Protein Kif7 Regulates Gli and Ezh2 for Initiating the Neuronal Differentiation of Enteric Neural Crest Cells during Development

Gastrointestinal motility disorders occur frequently in patients with ciliopathy, but the underlying genetic link is unclear. Mechanistically, Kif7 inhibited Gli2 in enteric neural crest cell, where Gli2 positively regulated the expression of Ezh2 by inhibiting the miR124-mediated suppression.
[Science Advances]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Age-Related Mitochondrial Alterations in Brain and Skeletal Muscle of the YAC128 Model of Huntington Disease

Scientists used the YAC128 murine model of Huntington’s disease to examine the effects of mutant huntingtin on mitochondrial parameters related to aging in brain and skeletal muscle.
[npj Aging and Mechanisms of Disease]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Early Prediction of Developing Spontaneous Activity in Cultured Neuronal Networks

Researchers used machine learning techniques to characterize and predict the developing spontaneous activity in mouse cortical neurons on microelectrode arrays during the first three weeks in vitro.
[Scientific Reports]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share