Mapping Molecular Subtype Specific Alterations in Breast Cancer Brain Metastases Identifies Clinically Relevant Vulnerabilities

The authors comprehensively dissected genomic, transcriptomic and clinical data in patient-matched longitudinal tumor samples, and unraveled distinct transcriptional programs enriched in brain metastasis.
[Nature Communications]
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Treatment of Kidney Clear Cell Carcinoma, Lung Adenocarcinoma and Glioblastoma Cell Lines with Hydrogels Made of DNA Nanostars

Investigators studied the biological response of three different cell lines to the treatment with DNA-GEL – a DNA-based hydrogel composed of interacting DNA nanostars.
[Biomaterials Science]
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NTT Research to Collaborate with Researchers at Harvard University on Computational Neurobiology

NTT Research, Inc., announced that it has entered a joint research agreement with scientists at Harvard University to study animal neuro-responses with the hope of informing future artificial intelligence systems.
[NTT Research, Inc.]
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Athira Pharma Announces Initiation of Patient Dosing in SHAPE, a Phase II Clinical Trial of ATH-1017 for the Treatment of Parkinson’s Disease Dementia and Dementia with Lewy Bodies

Athira Pharma, Inc. announced that patient dosing has begun in SHAPE, a Phase II clinical trial of ATH-1017 for the treatment of Parkinson’s disease dementia and Dementia with Lewy bodies. ATH-1017 is a small molecule designed to enhance the activity of Hepatocyte Growth Factor and its receptor, MET, to impact neurodegeneration and regenerate brain tissue.
[Athira Pharma, Inc.]
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Irradiation Causes Senescence, ATP Release, and P2X7 Receptor Isoform Switch in Glioblastoma

Researchers showed that P2X7A and B receptor isoform levels were inversely modulated during the post-irradiation recovery phase in glioblastoma cells.
[Cell Death & Disease]
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Selective Translation of Epigenetic Modifiers Affects the Temporal Pattern and Differentiation of Neural Stem Cells

Scientists found that depletion of Fbl, an rRNA methyltransferase, reduced translation of both Ezh2 methyltransferase and Kdm6b demethylase of H3 trimethylation in Lys27 and delayed the progression of the neural stem cell state.
[Nature Communications]
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Antisense Oligonucleotides as a Potential Treatment for Brain Deficits Observed in Myotonic Dystrophy Type 1

The authors indicated that the IONIS 486178 antisense oligonucleotide (ASO) targeted mutant DMPK mRNAs in the brain and strongly supported the feasibility of a therapy for dystrophia myotonica type 1 patients based on the intrathecal injection of an ASO.
[Gene Therapy]
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Extracellular Vesicles from Adipose-Derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery in a Mouse Model of Transient Middle Cerebral Artery Occlusion

The authors explored the contribution of miRNAs in adipose-derived stem cell-extracellular vesicles to the treatment of cerebral ischemia.
[Current Stem Cell Research & Therapy]
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Tau Interactome Maps Synaptic and Mitochondrial Processes Associated with Neurodegeneration

Researchers showed that frontotemporal dementia mutations impaired bioenergetics and markedly diminished Tau’s interaction with mitochondria proteins, which were downregulated in Alzheimer disease brains of multiple cohorts and correlated with disease severity.
[Cell]
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Identification and Functional Characterization of CD133+GFAP+CD117+Sca1+ Neural Stem Cells

C57BL/6 mice were used to isolate and identify CD133+GFAP+CD117+Sca1+ cells in the hippocampal dentate gyrus region of the mouse brain as a novel neural stem cell population, in terms of cell phenotype, self-renewal capacity, and differentiation capability.
[Molecular and Cellular Biochemistry]
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History-Dependent Dopamine Release Increases cAMP Levels in Most Basal Amygdala Glutamatergic Neurons to Control Learning

Researchers examined the dynamics of dopamine release and downstream signaling during multiple salient events occurring within tens of seconds and performed real-time tracking and manipulation of cyclic adenosine monophosphate (cAMP) in basal amygdala neurons in vitro and in vivo.
[Cell Reports]
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