Since higher education institutions ended in-person classes in March due to the COVID-19 pandemic, there has been uncertainty over what classes will look like in the fall. Universities will soon have to come up with an answer.
To determine whether microglia also prune myelin sheaths, scientists used zebrafish to visualize and manipulate interactions between microglia, oligodendrocytes, and neurons during development.
Investigators demonstrated an artificial neuron based on NbOx volatile memristor that not only realized traditional all-or-nothing, threshold-driven spiking and spatiotemporal integration.
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Scientists showed that the Activin ligand Myoglianin produced from glia downregulated the levels of the intrinsic temporal factor Imp in mushroom body neuroblasts.
Researchers investigated the effects of PCP4/PEP19 expression on neuronal differentiation by analyzing neurite outgrowth, and expression of neuronal differentiation markers in cultured human neuroblastoma M17 cells.
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Kitazono, I., Hamada, T., Yoshimura, T., Kirishima, M., Yokoyama, S., Akahane, T., & Tanimoto, A. (2020). PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-020-0462-z Cite
Scientists review how neural and vascular activity act on one another with regard to the blood–brain barrier and neurovascular coupling.
[Nature Reviews Neuroscience]
Investigators showed that activation of mouse astroglial type-1 cannabinoid receptors associated with mitochondrial membranes hampered the metabolism of glucose and the production of lactate in the brain, resulting in altered neuronal functions.
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Ziopharm Oncology, Inc. announced that the first patient with diffuse intrinsic pontine glioma has been dosed in its Phase I/II study of Ad-RTS-hIL-12 with veledimex for the treatment of pediatric brain tumors.
The authors summarize international recommendations, discuss them in light of the first available data from patients with COVID-19 receiving immunotherapy and provide an overview of management approaches in the COVID-19 era.
[Nature Reviews Neurology]
The new director of the National Science Foundation (NSF), Sethuraman “Panch” Panchanathan, is familiar with the dark clouds over the agency. His boss, President Donald Trump, keeps proposing big cuts to NSF’s budget. Two recent executive orders on immigration make it harder for foreign scientists—who make up a sizeable share of the U.S. research enterprise—to enter the country.
Scientists evaluated the safety and efficacy of dopaminergic progenitors (DAPs) derived from a clinical-grade human iPSC line. They confirmed the characteristics of DAPs by in vitro analyses.
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