Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Neuronal PAS Domain 1 Identifies a Major Subpopulation of Wakefulness-Promoting GABAergic Neurons in the Basal Forebrain

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists described a group of basal forebrain (BF) neurons expressing neuronal Per-Arnt-Sim (PAS) domain 1 (Npas1), a developmental transcription factor linked to neuropsychiatric disorders.

Aberrant CHCHD2-Associated Mitochondriopathy in Kii ALS/PDC Astrocytes

[Acta Neuropathologica] Leveraging advanced induced pluripotent stem cell technology, investigators cultivated multiple astrocyte lines to further investigate the Japanese variant of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC).

Modeling of Brain Tumors Using In Vitro, In Vivo, and Microfluidic Models: A Review of the Current Developments

[Heliyon] The authors discuss some of the most important in vitro, in vivo, and microfluidic brain tumor models that aim to address challenges, including difficulty in emulating the complexity of the brain and the surrounding microenvironment.

The Vascular Contribution of Apolipoprotein E to Alzheimer’s Disease

[Brain] The authors examine the evidence elucidating the cerebrovascular impact of both central and peripheral apolipoprotein E on the pathogenesis of Alzheimer’s disease.

The Role of Cellular Senescence in Neurodegenerative Diseases

[Archives Of Toxicology] Scientists elucidate the mechanism of cellular senescence in neurodegenerative disease pathogenesis, suggesting strategies to eliminate or restore senescent cells to a normal phenotype for treating such diseases.

Low-Intensity Ultrasound Ameliorates Brain Organoid Integration and Rescues Microcephaly Deficits Get Access Arrow

[Brain] Investigators reported that low-intensity ultrasound significantly increased neural progenitor cell proliferation and neuronal maturation in cortical organoids.

Fibulin-2 Is an Extracellular Matrix Inhibitor of Oligodendrocytes Relevant to Multiple Sclerosis

[Journal Of Clinical Investigation] The authors identified fibulin-2 (FBLN2) as a highly upregulated ECM component in lesions of MS and stroke, and in proteome databases of Alzheimer’s disease and traumatic brain injury.

Brain Organoids Engineered to Give Rise to Glia and Neural Networks after 90 Days in Culture Exhibit Human-Specific Proteoforms

[Frontiers In Cellular Neuroscience] Scientists demonstrated that cell fate and composition of unguided brain organoids was dictated by culture conditions during embryoid body formation, and that culture conditions at this stage could be optimized to result in the presence of glia-associated proteins and neural network activity as early as three-months in vitro.

FAU Researchers Receive $1M in FDOH Grants to Fight Alzheimer’s Disease

[Florida Atlantic University] Three Florida Atlantic University researchers at the forefront of Alzheimer’s disease research have each received a $350,000 grant from the Florida Department of Health’s “Ed and Ethel Moore Alzheimer’s Disease Research Program.

AC Immune And Takeda Sign Exclusive Option And License Agreement For Active Immunotherapy Targeting Amyloid Beta For Alzheimer’s Disease

[AC Immune SA] Takeda and AC Immune SA announced a worldwide option and license agreement for AC Immune’s active immunotherapies targeting toxic forms of amyloid beta, including ACI-24.060 for the treatment of Alzheimer’s disease.

Salidroside Promotes the Repair of Spinal Cord Injury by Inhibiting Astrocyte Polarization, Promoting Neural Stem Cell Proliferation and Neuronal Differentiation

[Cell Death Discovery] Immunofluorescence-staining corroborated salidroside’s capacity to stimulate nerve regeneration and remyelination, suppress glial scar hyperplasia, reduce the activation of neurotoxic A1 astrocytes, and facilitate neural stem cells migration towards the injured region.

Itaconate Protects Ferroptotic Neurons by Alkylating GPx4 Post Stroke

[Cell Death & Differentiation] Deficiency of Irg1 or depletion of neuronal Irg1 in striatal neurons was shown to exaggerate neuronal loss and behavioral dysfunction in an intracerebral hemorrhage (ICH) mouse model using transgenic mice.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.