Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Tissue- and Cell-Type-Specific Molecular and Functional Signatures of 16p11.2 Reciprocal Genomic Disorder Across Mouse Brain and Human Neuronal Models

[American Journal of Human Genetics] Researchers performed transcriptome profiling of 350 libraries from six tissues in mouse models harboring copy-number variants (CNVs) of the syntenic 7qF3 region, as well as cellular, transcriptional, and single-cell analyses in 54 isogenic neural stem cell, induced neuron, and cerebral organoid models of CRISPR-engineered 16p11.2 CNVs.

The Alternative Splicing of Intersectin 1 Regulated by PTBP1 Promotes Human Glioma Progression

[Cell Death & Disease] Transcriptome analysis using a large glioma cohort indicated that the ratio of ITSN1-S/ITSN1-L was positively correlated with glioma grading and poor prognosis.

Building In Vitro Models of the Brain To Understand the Role of APOE in Alzheimer’s Disease

[Life Science Alliance] Scientists provide a brief background on Alzheimer’s disease (AD) in the context of APOE susceptibility and feature work employing hiPSC-derived brain cell and tissue models to interrogate the contribution of APOE in driving AD pathology.

CNS Myelination Requires VAMP2/3-Mediated Membrane Expansion in Oligodendrocytes

[Nature Communications] Through live imaging, the authors discovered that VAMP2/3-mediated exocytosis drives membrane expansion within myelin sheaths to initiate wrapping and power sheath elongation.

Single Cell Atlas of Spinal Cord Injury in Mice Reveals a Pro-Regenerative Signature in Spinocerebellar Neurons

[Nature Communications] Scientists used single nucleus RNA sequencing to profile how each cell type in the lumbar spinal cord changes after a thoracic injury in mice.

Tanshinone IIA-Loaded Nanoparticle and Neural Stem Cell Therapy Enhances Recovery in a Pig Ischemic Stroke Mode

[Stem Cells Translational Medicine] Researchers evaluated the potential of Tan IIA drug-loaded nanoparticles to improve iPSC-derived neural stem cells engraftment and efficacy, thus potentially leading to enhanced cellular, tissue, and functional recovery in a translational pig ischemic stroke model.

NIH’s BRAIN Initiative Puts $500 Million Into Creating Most Detailed Ever Human Brain Atlas

[ScienceInsider] The BRAIN Initiative, the nine-year-old, multibillion-dollar US neuroscience effort, announced its most ambitious challenge yet: compiling the world’s most comprehensive map of cells in the human brain.

A Midbrain-Reticulotegmental Circuit Underlies Exaggerated Startle under Fear Emotions

[Molecular Psychiatry] The authors revealed a neural projection from dorsal raphe nucleus to a startle-controlling center reticulotegmental nucleus that mediated enhanced startle response under fear condition.

MEX3A Impairs DNA Mismatch Repair Signaling and Mediates Acquired Temozolomide Resistance in Glioblastoma

[Cancer Research] The authors reported significant upregulation of Mex-3 RNA binding family member A in bioblastoma tissues and cell lines following temozolomide treatment.

Ketogenic Diet Uncovers Differential Metabolic Plasticity of Brain Cells

[Science Advances] Scientists generated a proteome atlas of the major central nervous system cell types from young and adult mice, after feeding the therapeutically relevant low-carbohydrate, high-fat ketogenic diet and during neuroinflammation.

Parkinson-Causing Mutations in LRRK2 Impair the Physiological Tetramerization of Endogenous α-Synuclein in Human Neurons

[npj Parkinsons Disease] Patient neurons carrying G2019S, the most prevalent LRRK2 mutation, or R1441C each had decreased T:M ratios and pSer129 hyperphosphorylation of their endogenous αSyn along with increased phosphorylation of Rab10, a widely reported substrate of LRRK2 kinase activity.

Transcriptional Dynamics of Murine Motor Neuron Maturation In Vivo and In Vitro

[Nature Communications] Researchers showed that mouse motor neurons exhibited pervasive changes in gene expression and accessibility of associated regulatory regions from embryonic till juvenile age.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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