Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Insights for Disease Modeling from Single-Cell Transcriptomics of iPSC-Derived Ngn2-Induced Neurons and Astrocytes across Differentiation Time and Co-Culture

[BMC Biology] Scientists examined the homogeneity and similarity of human-induced pluripotent stem cells (hiPSC) derived neuron (hiPSC-N) and hiPSC derived astrocyte A (hiPSC-A) to their in vivo counterparts, the impact of different lengths of time post Ngn2 induction on hiPSC-N (15 or 21 days), and the impact of hiPSC-N/hiPSC-A co-culture.

Rare Genetic Variation in Fibronectin 1 (FN1) Protects against APOEε4 in Alzheimer’s Disease

[Acta Neuropathologica] Researchers hypothesized that APOEε4 carriers without dementia might carry genetic variations that could protect them from developing APOEε4-mediated Alzheimer's Disease pathology.

Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons

[Nature Communications] To understand the mechanistic significance of inter-regional projections on development of neural circuits, researchers investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.

Microtubule Polarity Determines the Lineage of Embryonic Neural Precursor in Zebrafish Spinal Cord

[Communications Biology] Investigators found two distinct pools of neural precursors based on Sara endosome inheritance and spindle-microtubule enrichment. Symmetric or asymmetric levels of spindle-microtubules drive differently Sara endosomes inheritance and predict neural precursor lineage.

Essential Pharma Acquires Renaissance Pharma Ltd with Its Clinical Stage Immunotherapy for the Treatment of High-Risk Neuroblastoma

[Essential Pharma] Essential Pharma announced that it has completed the acquisition of the entire issued share capital of Renaissance Pharma Ltd. Renaissance Pharma is a clinical stage pharmaceutical company focused on the development of life changing therapies in pediatric rare disease.

Dynamic Molecular Network Analysis of iPSC-Purkinje Cells Differentiation Delineates Roles of ISG15 in SCA1 at the Earliest Stage

[Communications Biology] The authors investigated the earliest molecular pathology of spinocerebellar ataxia type 1 (SCA1), a rare familial neurodegenerative disease that primarily induces death and dysfunction of cerebellum Purkinje cells.

SBU Senior Nishtha Tripathi to Be Inducted Into Competitive ASBMB Honor Society

[At Bonaventure University] St. Bonaventure University senior Nishtha Tripathi of Austin, Texas, is among 31 undergraduate students nationwide who were accepted into the competitive American Society for Biochemistry and Molecular Biology Honor Society for 2024.

Human iPSC 4R Tauopathy Model Uncovers Modifiers of Tau Propagation

[Cell] The authors engineered hiPSC-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons.

Autophagy and Exosomes; Inter-Connected Maestros in Alzheimer’s Disease

[Inflammopharmacology] The authors investigated how modulating autophagy affected the exosomal release of amyloid and tau proteins in animal models of Alzheimer's disaease.

Molecular and Cellular Mechanisms of Selective Vulnerability in Neurodegenerative Diseases

[Nature Reviews Neuroscience] The author highlight how recent methodological innovations — including single-cell transcriptomics, CRISPR-based screens, and human cell-based models of disease — are enabling new breakthroughs in our understanding of selective vulnerability.

Immunological Aspects of Central Neurodegeneration

[Cell Discovery] Scientists critically discuss immunological mechanisms of central neurodegeneration and propose potential strategies to correct neurodegeneration-associated immunological dysfunction with therapeutic purposes.

Neuronal Activity Rapidly Reprograms Dendritic Translation via eIF4G2:uORF Binding

[Nature Neuroscience] To monitor how depolarization impacted local dendritic biology, researchers employed a dendritically targeted proximity labeling approach followed by crosslinking immunoprecipitation, ribosome profiling, and mass spectrometry.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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