Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
NYU Langone Awarded $1.6 Million to Investigate Alzheimer’s & Parkinson’s Progression Through the Eye
[NYU Langone Health] Researchers at NYU Langone Health were awarded $1.6 million from the National Institutes of Health to investigate changes in the eye that may indicate early signs of Alzheimer’s disease and Parkinson’s disease.
Consequences of Trisomy 21 for Brain Development in Down Syndrome
[Nature Reviews Neuroscience] Recent technical advances, such as single-cell omics and the development of induced pluripotent stem cell models of Down syndrome (DS), now enable in-depth analyses of the biochemical and molecular drivers of altered brain development in DS.
Meningeal Lymphatic Function Promotes Oligodendrocyte Survival and Brain Myelination
[Immunity] Investigators showed that inducing meningeal lymphatic vessel ablation in adult mice led to gene expression changes in glial cells, followed by reductions in mature oligodendrocyte numbers and specific lipid species in the brain.
In Vivo Perturb-Seq of Cancer and Microenvironment Cells Dissects Oncologic Drivers and Radiotherapy Responses in Glioblastoma
[Genome Biology] The authors developed a multiplex in vivo perturb-seq CRISPRi platform for single-cell genetic screens in cancer and tumor microenvironment cells that leveraged intracranial convection enhanced delivery of sgRNA libraries into mouse models of glioblastoma.
Systemic Determinants of Brain Health in Aging
[Nature Reviews Neurology] Researchers provide a framework to indicate how organ dysfunction can alter brain homeostasis and promote neurodegeneration, with a focus on dementia.
Prediction of Brain Metastasis Development with DNA Methylation Signatures
[Nature Medicine] Researchers explored the utility and accuracy of noninvasive plasma biomarkers for early brain metastasis (BM) identification. They showed that plasma cell-free circulating tumor DNA methylomes could noninvasively differentiate BM from other main differential diagnoses via peripheral blood sampling.
Single-Neuron Representations of Odors in the Human Brain
[Nature] Investigators reported recordings of single-neuron activity in the piriform cortex and medial temporal lobe in awake humans performing an odor rating and identification task, identifying odor-modulated neurons within the piriform cortex, amygdala, entorhinal cortex, and hippocampus.
Sustained Effect of Prasinezumab on Parkinson’s Disease Motor Progression in the Open-Label Extension of the PASADENA Trial
[Nature Medicine] The Phase II trial of Anti-alpha-Synuclein Antibody in Early Parkinson’s Disease (PASADENA) was an ongoing double-blind, placebo-controlled trial evaluating the safety and efficacy of prasinezumab in early-stage Parkinson’s disease.
Modeling Parkinson’s Disease Pathology in Human Dopaminergic Neurons by Sequential Exposure to α-Synuclein Fibrils and Proinflammatory Cytokines
[Nature Neuroscience] Scientists found that induced pluripotent stem cell-derived human dopaminergic neurons form lewy body-like inclusions after treatment with α-synuclein preformed fibrils but only when coupled to a model of immune challenge or when co-cultured with activated microglia-like cells.
Dr. Vidhya Rangaraju Wins Prestigious NIH Director’s New Innovator Award for Research on Brain Energy Mechanisms
[MPFI] Dr. Vidhya Rangaraju, research group leader at the Max Planck Florida Institute for Neuroscience (MPFI) has been awarded the prestigious NIH Director’s New Innovator Award for her research on how the brain generates and regulates energy.
Widespread Transposable Element Dysregulation in Human Aging Brains with Alzheimer’s Disease
[Alzheimers & Dementia] Scientists identified 26,188 genome-wide significant transposable element expression quantitative trait loci in human aged brains, and pinpointed a neuron-specific suppressive role of the activated short interspersed nuclear element on expression of C1QTNF4 via reducing neuroinflammation in human iPSC-derived neurons.
Salk Institute’s Nicola Allen Receives 2024 NIH Director’s Pioneer Award
[Salk Institute] The National Institutes of Health (NIH) has selected Salk Associate Professor Dr. Nicola Allen to receive a 2024 NIH Director’s Pioneer Award. Dr. Allen will receive $3.5 million over five years to support her latest research, which investigates how plasticity in the adult brain could be enhanced.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
