Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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GSK, UK Dementia Research Institute (UK DRI) and Health Data Research UK (HDR UK) to Collaborate on First-of-Its-Kind Dementia Research Initiative

March 25, 2025

[GSK] GSK plc announced a major new research collaboration with the UK DRI and HDR UK to advance understanding of neurodegeneration with a first-of-its-kind dementia study.

How Microglia Contribute to the Induction and Maintenance of Neuropathic Pain

March 25, 2025

[Nature Neuroscience] Microglia respond to and modulate neuronal activity during establishment and persistence of neuropathic pain states, and microglia–neuron pathways provide targets that can be exploited to attenuate abnormal neuronal activity and provide pain relief.

Knowing the Enemy: Strategic Targeting of Complement to Treat Alzheimer Disease

March 25, 2025

[Nature Reviews Neurology] The authors provide justification, largely from preclinical mouse models but also from correlates with human tissue and biomarkers, for targeting specific complement components for therapeutic intervention in Alzheimer disease.

Neural Ensembles That Encode Nocifensive Mechanical and Heat Pain in Mouse Spinal Cord

March 25, 2025

[Nature Neuroscience] By means of genetic capturing, activity manipulation and single-cell RNA sequencing, researchers identified distinct neural ensembles in the adult mouse spinal cord encoding mechanical and heat pain.

Brain 5-Hydroxymethylcytosine Alterations Are Associated with Alzheimer’s Disease Neuropathology

March 25, 2025

[Nature Communications] Scientists reported a genome-wide profiling of 5-hydroxymethylcytosine in 1079 autopsied brains of older individuals and assessed its association with multiple measures of Alzheimer’s disease pathologies.

Enteric Neuronal Piezo1 Maintains Mechanical and Immunological Homeostasis by Sensing Force

March 25, 2025

[Cell] The authors established that the mechanosensor Piezo1 was functionally expressed in cholinergic enteric neurons.

Targeting HINT1 to Improve Synaptic Plasticity: Toward Loganin As a New Antidepressant Strategy

March 25, 2025

[Molecular Psychiatry] Scientists reported that loganin directly targeted histidine triad nucleotide-binding protein 1 (HINT1) to alleviate depressive-like behaviors. Overexpression of HINT1 in the hippocampus induces depressive-like behaviors.

Escitalopram for Agitation in Alzheimer’s Dementia: A Randomized Controlled Phase III Trial

March 25, 2025

[Nature Medicine] In this double-masked randomized placebo-controlled trial, investigators assessed the efficacy and safety of escitalopram in treating agitation in Alzheimer's disease after failure of a psychosocial intervention.

Sertm2 Is a Conserved Micropeptide That Promotes GDNF-Mediated Motor Neuron Subtype Specification

March 20, 2025

[EMBO Reports] Scientists investigated the function of murine micropeptide Sertm2, encoded by the lncRNA A730046J19Rik, during spinal motor neuron development.

Primary Cilia Shape Postnatal Astrocyte Development through Sonic Hedgehog Signaling

March 20, 2025

[Journal of Cell Science] Researchers showed that a sub-population of developing astrocytes in the prefrontal cortex were ciliated. This population corresponded to proliferating astrocytes and largely expressed the ciliary protein ARL13B.

Genetic Sequencing Project Receives More Than $8 Million in Funding

March 19, 2025

[McGill University] A project led by Drs. Ziv Gan-Or and Martine Tétreault has received more than $8 million to sequence the genomes of 8,700 people, to map the role of genetics in neurological disorders.

Dock1 Functions in Schwann Cells to Regulate Development, Maintenance, and Repair

March 19, 2025

[Journal of Cell Biology] The authors demonstrated that Dock1 was necessary for myelin maintenance and remyelination after injury in adult zebrafish.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.