Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Glomerular Endothelial Cell Receptor ADGRF5 and the Integrity of the Glomerular Filtration Barrier

[Journal of The American Society of Nephrology] The impact of ADGRF5 deletion on glomerular morphology, kidney function, and glomerular endothelial gene/protein expression were analyzed using ADGRF5 knockout (Adgrf5−/−) mice and human primary glomerular endothelial cells.

Fetal Liver CD34+ Contain Human Immune and Endothelial Progenitors and Mediate Solid Tumor Rejection in NOG Mice

[Stem Cell Research & Therapy] Investigators demonstrated that CD14+CD34+ cells were capable of reconstituting Factor VIII-producing liver sinusoidal endothelial cells in fetal liver-immunocompromised NOD/Shi-scid Il2rgnull.

Endothelial Injury and Dysfunction with Emerging Immunotherapies in Multiple Myeloma, the Impact of COVID-19, and Endothelial Protection with a Focus on the Evolving Role...

[Blood Reviews] Multiple myeloma and COVID-19, plus post-acute sequelae of SARS-CoV-2 infection, are associated with endothelial dysfunction and injury, with overlapping inflammatory pathways and coagulopathies.

Outlook Therapeutics® Receives European Commission Marketing Authorization for LYTENAVA™ for the Treatment of Wet AMD

[Outlook Therapeutics, Inc.] Outlook Therapeutics, Inc. announced that the European Commission has granted Marketing Authorization for LYTENAVA, an ophthalmic formulation of bevacizumab for the treatment of wet age-related macular degeneration (AMD) in the EU.

Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction

[Circulation] Investigators explored endothelial and cardiac function in an experimental model of aortic valve stenosis (AS) mice devoid of standard modifiable cardiovascular risk factors and human cohorts with AS scheduled for transcatheter aortic valve replacement.

Interferon-γ Induces Combined Pyroptotic Angiopathy and APOL1 Expression in Human Kidney Disease

[Cell Reports] Using human kidney organoids, primary endothelial cells, and patient samples, researchers demonstrated that IFN-γ induced pyroptotic angiopathy in combination with APOL1 expression.

Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells

[Journal of The American Society of Nephrology] Set7 regulated the phenotypic endothelial–mesenchymal transition switch and suggested that targeting the lysine methyltransferase could protect glomerular cell injury in diabetic kidney disease.

Using Organ-on-a-Chip Technology to Study Haemorrhagic Activities of Snake Venoms on Endothelial Tubules

[Scientific Reports] Scientists presented an organ-on-a-chip approach to investigate the effects of four different snake venoms on a perfused microfluidic blood vessel model.

Unraveling the Role of LDHA and VEGFA in Oxidative Stress: A Pathway to Therapeutic Interventions in Cerebral Aneurysms

Scientists investigated the role of lactate metabolism and lactate-related genes, particularly LDHA and vascular endothelial growth factor A (VEGFA) genes, in VECs during oxidative...

3D-Bioprinted GelMA/Gelatin/Amniotic Membrane Extract (AME) Scaffold Loaded with Keratinocytes, Fibroblasts, and Endothelial Cells for Skin Tissue Engineering

[Scientific Reports] Researchers fabricated and characterized a bi-layered GelMA-gelatin scaffold using 3D bioprinting. The upper section of the scaffold was encompassed with keratinocytes to simulate the epidermis, while the lower section included fibroblasts and HUVEC cells to mimic the dermis.

Outlook Therapeutics® Receives European Commission Marketing Authorization for LYTENAVA™ (bevacizumab gamma) for the Treatment of Wet AMD

Outlook Therapeutics, Inc. announced that the European Commission has granted Marketing Authorization for LYTENAVA™ (bevacizumab gamma), an ophthalmic formulation of bevacizumab for the treatment...

Aerobic Glycolysis of Vascular Endothelial Cells: A Novel Perspective in Cancer Therapy

The authors discuss the differences in aerobic glycolysis of vascular endothelial cells (ECs) under normal and pathological conditions, focusing on the recent research progress...

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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