Endothelial Cell Mechanics and Blood Flow Forces in Vascular Morphogenesis

Scientists discuss the cellular and molecular mechanisms involved in vascular network formation and how these intrinsic mechanisms are influenced by hemodynamic forces provided by pressurized blood flow.
[Seminars in Cell & Developmental Biology]
Endothelial cell mechanics and blood flow forces in vascular morphogenesis - ScienceDirect. (n.d.). Retrieved June 22, 2021, from https://www.sciencedirect.com/science/article/abs/pii/S1084952121001567?via%3Dihub Cite
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Selenium Nanoparticles with Various Morphology for Antiangiogenesis through bFGF-Mediated P13K/AKT Signaling Pathways

Selenium nanoparticles could competitively inhibit the binding of bFGF to fibroblast growth factor receptor through direct binding to bFGF, down-regulate the expression of bFGF in HUVEC cells, and significantly reduce the MAPK/Erk and P13K/AKT pathways activation of signaling molecules to regulate HUVEC cell migration and angiogenesis.
[Nanotechnology]
Selenium nanoparticles with various morphology for antiangiogenesis through bFGF-mediated P13K/AKT signaling pathways - IOPscience. (n.d.). Retrieved June 22, 2021, from https://iopscience.iop.org/article/10.1088/1361-6528/ac0d1d Cite
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Genomic Locus Proteomic Screening Identifies the NF-κB Signaling Pathway Components NFκB1 and IKBKG as Transcriptional Regulators of Ripk3 in Endothelial Cells

Scientists found that 41 nuclear proteins are specifically enriched at the Ripk3 locus, including the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway components NFκB1 and IKBKG.
[PLOS ONE]
Genomic locus proteomic screening identifies the NF-κB signaling pathway components NFκB1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells. (n.d.). Retrieved June 22, 2021, from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253519 Cite
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Nicotinamide N-Methyltransferase in Endothelium Protects against Oxidant Stress-Induced Endothelial Injury

Researchers characterized the functional activity of nicotinamide N-methyltransferase (NNMT) in the endothelium and tested whether NNMT regulated endothelial cell viability.
[Biochimica et Biophysica Acta (BBA) – Molecular Cell Research]
Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury - ScienceDirect. (n.d.). Retrieved June 22, 2021, from https://www.sciencedirect.com/science/article/abs/pii/S0167488921001361?via%3Dihub Cite
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Tumor Irradiation Combined with Vascular-Targeted Photodynamic Therapy Enhances Antitumor Effects in Pre-Clinical Prostate Cancer

Scientists investigated whether sequential delivery of fractionated radiotherapy (FRT) followed by vascular-targeted photodynamic therapy (VTP) days later improved flank TRAMP-C1 prostate cancer tumor allograft control compared to monotherapy with FRT or VTP.
[British Journal of Cancer]
Sjoberg, H. T., Philippou, Y., Magnussen, A. L., Tullis, I. D. C., Bridges, E., Chatrian, A., Lefebvre, J., Tam, K. H., Murphy, E. A., Rittscher, J., Preise, D., Agemy, L., Yechezkel, T., Smart, S. C., Kinchesh, P., Gilchrist, S., Allen, D. P., Scheiblin, D. A., Lockett, S. J., … Bryant, R. J. (2021). Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-021-01450-6 Cite
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Integration of Substrate- and Flow-Derived Stresses in Endothelial Cell Mechanobiology

The authors review endothelial cell responses to substrate-derived biophysical cues, namely topography, curvature, and stiffness, as well as to flow-derived stresses, notably shear stress, pressure, and tensile stresses.
[Communications Biology]
Dessalles, C. A., Leclech, C., Castagnino, A., & Barakat, A. I. (2021). Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology. Communications Biology, 4(1), 1–15. https://doi.org/10.1038/s42003-021-02285-w Cite
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The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

The emerging role of BMP signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature.
[International Journal of Molecular Sciences]
Ponomarev, L. C., Ksiazkiewicz, J., Staring, M. W., Luttun, A., & Zwijsen, A. (2021). The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology. International Journal of Molecular Sciences, 22(12), 6364. https://doi.org/10.3390/ijms22126364 Cite
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Multifunctional 3D-Printed Wound Dressings

Hydrogel wound dressings carrying antibacterial silver nanoparticles and vascular endothelial growth factor with predetermined release profiles were utilized to study the physiological response of the wound in a mouse model.
[ACS Nano]
Alizadehgiashi, M., Nemr, C. R., Chekini, M., Pinto Ramos, D., Mittal, N., Ahmed, S. U., Khuu, N., Kelley, S. O., & Kumacheva, E. (2021). Multifunctional 3D-Printed Wound Dressings. ACS Nano. https://doi.org/10.1021/acsnano.1c04499 Cite
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Sequential Regulation of Hemogenic Fate and Hematopoietic Stem and Progenitor Cell Formation from Arterial Endothelium by Ezh1/2

Single-cell RNA sequencing across ezh1 genotypes revealed a dropout of ezh1+/− cells among arterial endothelium associated with positive regulation of gene transcription.
[Stem Cell Reports]
Soto, R. A., Najia, M. A. T., Hachimi, M., Frame, J. M., Yette, G. A., Rocha, E. L. da, Stankunas, K., Daley, G. Q., & North, T. E. (2021). Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.05.014 Cite
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Delivery of Endothelial Cell-Laden Microgel Elicits Angiogenesis in Self-Assembling Ultrashort Peptide Hydrogels In Vitro

Scientists used a modular tissue-engineering approach, embedding SUP microgels loaded with human umbilical vein endothelial cells into a 3D SUP hydrogel containing human dermal fibroblast neonatal cells to trigger angiogenesis.
[ACS Applied Materials & Interfaces]
Ramirez-Calderon, G., Susapto, H. H., & Hauser, C. A. E. (2021). Delivery of Endothelial Cell-Laden Microgel Elicits Angiogenesis in Self-Assembling Ultrashort Peptide Hydrogels In Vitro. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.1c03787 Cite
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Molecular Tension in Syndecan-1 Is Regulated by Extracellular Mechanical Cues and Fluidic Shear Stress

Scientists examined the changes in mechanical tension of syndecan-1, a cell surface proteoglycan that is an integral part of the glycocalyx, in response to substrate stiffness and fluidic shear stress.
[Biomaterials]
Le, V., Mei, L., Voyvodic, P. L., Zhao, C., Busch, D. J., Stachowiak, J. C., & Baker, A. B. (2021). Molecular tension in syndecan-1 is regulated by extracellular mechanical cues and fluidic shear stress. Biomaterials, 275, 120947. https://doi.org/10.1016/j.biomaterials.2021.120947 Cite
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