3D Tumor Angiogenesis Models: Recent Advances and Challenges

Scientists summarize recent advancements of 3D tumor vascular model systems which include tissue engineering-based tumor models; vascular organoid models, and organ-on-chips and their importance in replicating the tumor angiogenesis along with the associated challenges to design improved models.
[Journal of Cancer Research and Clinical Oncology]
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Nutraceuticals and Their Role in Tumor Angiogenesis

The literature concerning the pro-angiogenic and/or anti-angiogenic nutraceuticals and the possible activated pathways in cancer and other non-neoplastic diseases by in vivo and in vitro experiments are reviewed.
[Experimental Cell Research]
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Merck and Eisai Receive Positive EU CHMP Opinions for KEYTRUDA® (pembrolizumab) Plus LENVIMA® (Lenvatinib) in Two Different Types of Cancer

Merck announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted positive opinions recommending approval of the combination of KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, for two different indications.
[Merck (BusinessWire, Inc.)]
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Small Molecule Compound M12 Reduces Vascular Permeability in Obese Mice via Blocking Endothelial TRPV4–Nox2 Interaction

The authors showed that interrupting TRPV4–Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.
[Acta Pharmacologica Sinica]
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SDF-1 Secreted by Mesenchymal Stem Cells Promotes the Migration of Endothelial Progenitor Cells via CXCR4/PI3K/AKT Pathway

The authors investigated whether stromal cell-derived factor (SDF)-1 secreted by mesenchymal stem cells contributed to endothelial progenitor cell migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases/protein kinase B signaling pathway.
[Journal of Molecular Histology]
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MARCO+ Lymphatic Endothelial Cells Sequester Arthritogenic Alphaviruses to Limit Viremia and Viral Dissemination

Following subcutaneous inoculation, arthritogenic alphavirus particles drained via the lymph and were rapidly captured by MARCO+ lymphatic endothelial cells in the draining lymph node, limiting viral spread to the bloodstream.
[EMBO Journal]
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Calcium-Channel-Blockers Exhibit Divergent Regulation of Cancer Extravasation through the Mechanical Properties of Cancer Cells and Underlying Vascular Endothelial Cells

Researchers examined the role of calcium-channel blocking drugs on mechanics of extravasating cancer cells, choosing two clinically-approved calcium-channel blockers as model antihypertensive drugs to simultaneously target cancer cells and an underlying monolayer of endothelial cells.
[Cell Biochemistry and Biophysics]
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Propranolol Inhibits the Angiogenic Capacity of Hemangioma Endothelia via Blocking β-Adrenoceptor in Mast Cell

Hemangioma endothelial cells were co-cultured with propranolol-treated HMC-1s supernatants, and their proliferation and apoptosis were investigated.
[Pediatric Research]
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Hexokinase 2-Driven Glycolysis in Pericytes Activates Their Contractility Leading to Tumor Blood Vessel Abnormalities

The authors developed a method that combines magnetic beads and flow cytometry cell sorting to isolate pericytes from tumors and normal adjacent tissues from patients with non-small cell lung cancer and hepatocellular carcinoma.
[Nature Communications]
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Hansoh Pharma and OliX Pharmaceuticals Enter into Licensing and Collaboration Agreement to Develop and Commercialize siRNA Therapeutics in Greater China

Hansoh Pharmaceutical Group Co, Ltd and OliX Pharmaceuticals, Inc. announced a licensing and collaboration agreement to discover, develop and commercialize siRNA therapeutics in key targeted indications in Greater China, which includes mainland China, Taiwan, Hong Kong and Macau.
[Hansoh Pharmaceutical Group Co, Ltd (GlobeNewswire, Inc.)]
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sFlt-1 and CA 15.3 Are Indicators of Endothelial Damage and Pulmonary Fibrosis in SARS-CoV-2 Infection

Scientists investigated the association of sFLT-1 and CA 15.3 with endothelial damage and pulmonary fibrosis.
[Scientific Reports]
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