Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Epidermal Growth Factor-Like Domain 7 Drives Brain Lymphatic Endothelial Cell Development through Integrin αvβ3

[Nature Communications] Researchers showed that Egfl7 was expressed in both blood and lymphatic endothelial cells. They generate an egfl7cq180 mutant with a 13-bp-deletion in exon 3 leading to reduced expression of Egfl7.

The BCR::ABL1 Tyrosine Kinase Inhibitors Ponatinib and Nilotinib Differentially Affect Endothelial Angiogenesis and signaling

[Molecular and Cellular Biochemistry] Scientists investigated the effects of three BCR::ABL1 inhibitors, ponatinib, nilotinib and imatinib, on angiogenesis and signaling in human endothelial cells in response to vascular endothelial growth factor.

tRNA-Derived Fragment tRF-30 Propels Diabetes-Induced Retinal Microvascular Complications by Regulating STAT3 Signaling

[Cell Biology International] Researchers revealed whether modulation of tRF-30 expression could attenuate pathological retinal neovascular diseases. Their findings demonstrated a significant upregulation of tRF-30 expression levels in both in vivo models of diabetic retinopathy and in vitro endothelial sprouting models.

MiR-424-5p Inhibits Proliferation, Migration, Invasion and Angiogenesis of the HTR-8/SVneo Cells Through Targeting LRP6 Mediated β-catenin

[Reproductive Sciences] Scientists investigated the effects of miR-424-5p on biological behaviors and angiogenesis of the HTR-8/SVneo Cells. The expression of LRP6, β-catenin, matrix metalloproteinase-2, placental growth factor, and vascular endothelial growth factor were measured by qPCR and Western blot assays.

Outlook Therapeutics® Announces UK MHRA Marketing Authorization of LYTENAVA™ (bevacizumab gamma) for the Treatment of Wet AMD

[Outlook Therapeutics, Inc.] Outlook Therapeutics, Inc. announced that the United Kingdom Medicines and Healthcare products Regulatory Agency has granted marketing authorization for LYTENAVA (bevacizumab gamma), an ophthalmic formulation of bevacizumab for the treatment of wet AMD in the UK.

Single-Cell Atlas of the Human Brain Vasculature Across Development, Adulthood and Disease

[Nature] Investigators performed single-cell RNA sequencing analysis of 606,380 freshly isolated endothelial cells, perivascular cells and other tissue-derived cells from 117 samples, from 68 human fetuses and adult patients to construct a molecular atlas of the developing fetal, adult control and diseased human brain vasculature.

Ginsenoside CK Cooperates with Bone Mesenchymal Stem Cells to Enhance Angiogenesis Post-stroke via GLUT1 and HIF-1α/VEGF Pathway

[Phytotherapy Research] Researchers applied compound K (CK) to investigate if CK could promote the survival of mesenchymal stem cells and differentiation into brain microvascular endothelial-like cells, thereby alleviating stroke symptoms.

Pathogenesis of Cardiovascular Diseases: Effects of Mitochondrial CF6 on Endothelial Cell Function

[Molecular and Cellular Biochemistry] The authors offer a comprehensive exploration of coupling factor 6 (CF6) in the context of cardiovascular disease (CVD), providing mechanistic insights into its role in processes impacting CVD, with a focus on CF6 functions, intracellular signaling, and regulatory mechanisms in vascular endothelial cells.

TMAO Impairs Mouse Aortic Vasodilation by Inhibiting TRPV4 Channels in Endothelial Cells

[Journal of Cardiovascular Translational Research] Ca2+ imaging of vascular tissue showed that trimethylamine oxide (TMAO) inhibited TRPV4-mediated Ca2+ influx into aortic endothelial cells in a dose-dependent manner. A whole-cell patch clamp assay showed that TMAO blocked TRPV4-mediated cation currents.

Subconjunctival Aflibercept Inhibits Corneal Angiogenesis and VEGFR-3+CD11b+ Cells

[Graefe'S Archive For Clinical and Experimental Ophthalmology] Scientists investigated the effects of subconjunctival injection of aflibercept, a soluble protein decoy for VEGFR-1 and VEGFR-2, on corneal angiogenesis and VEGFR-expressing CD11b+ cells in a mouse model of suture-induced corneal neovascularization.

A Novel lncRNA LOC101928222 Promotes Colorectal Cancer Angiogenesis by Stabilizing HMGCS2 mRNA and Increasing Cholesterol Synthesis

[Journal of Experimental & Clinical Cancer Research] LOC101928222 expression was upregulated in coloretal cancer (CRC) and was correlated with a worse outcome. Moreover, LOC101928222 was shown to promote migration, invasion, and angiogenesis in CRC.

Mtnr1b Deletion Disrupts Placental Angiogenesis through the VEGF Signaling Pathway Leading to Fetal Growth Restriction

[Pharmacological Research] Mechanistical studies uncovered that Mtnr1b knockout increased placental oxidative stress and apoptosis but reduced the angiogenesis. The RNA sequencing combined with histochemistry study identified the reduced angiogenesis and placental vascular density in Mtnr1b knockout mice.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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