Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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Foundation for Angelman Syndrome Therapeutics Announces Agreement with Apertura Gene Therapy for Access to Blood-Brain Barrier-Crossing Capsid

August 10, 2026

[Apertura Gene Therapy] The Foundation for Angelman Syndrome Therapeutics (FAST) announced that it has entered into an agreement with Apertura Gene Therapy. Under the agreement, FAST may access TfR1 CapX™, Apertura’s blood-brain barrier-crossing capsid technology, in investigational gene therapy programs designed for the treatment of Angelman syndrome.

Good and Crouch Investigate Biomarkers of Fontan Failure

August 10, 2026

[Tickle College of Engineering] Drs. Bryan Good and Colleen Crouch were awarded a three-year, $600,000 grant from the nonprofit Additional Ventures to search for biomarkers in and around the heart in collaboration with pediatric Fontan specialists from the University of Tennessee Health Sciences Center (UTHSC) in Memphis, Tennessee, and the Nationwide Children’s Hospital in Columbus, Ohio.

Engineering Functional Human Vasculature: iPSC-Derived Vascular Cells and Organoids for Disease Modeling and Translation

August 10, 2026

[Vascular Pharmacology] Evidence from studies of iPSC-derived vascular systems, spanning both two-dimensional differentiation models and three-dimensional organoid platforms, highlights the critical roles of hemodynamic cues, together with metabolic and immune signaling, in driving the coordinated maturation of endothelial and mural compartments.

Endophilin A2 Improves Endothelial Dysfunction by Counteracting eNOS Proteasomal Degradation

August 10, 2026

[European Heart Journal] Scientists investigated the function of Endophilin A2 in blood pressure homeostasis with particular emphasis on elucidating its mechanism in regulating endothelial nitric oxide synthase (eNOS) protein stability.

Dynamic Stiffness Enables Stage-Specific Properties Mediating Functional Endothelialization on Vascular Implants

August 10, 2026

[Science Advances] Researchers developed a biomimetic coating with dynamic stiffness via layer-by-layer assembly of recombinant humanized type III collagen and cystamine-modified hyaluronic acid, followed by postcrosslinking.

Engineered Microvascular Model of the Blood-Brain-Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

August 10, 2026

[Advanced Healthcare Materials] Scientists established an in vitro model of the diffuse midline glioma (DMG)-blood–brain–tumor barrier, comprised of patient-derived DMG tumor cells and primary human brain microvascular endothelial cells, astrocytes, and vascular pericytes, embedded in a fibrin matrix within a microfluidic chip.

Recipient Endothelial IRF1 Mediates IFNγ-Driven Tissue Tolerance in Mouse Models of Acute Graft-Versus-Host Disease

August 10, 2026

[Blood] Single cell RNA-sequencing of endothelial cells (ECs) isolated from a graft-versus-host-disease target organ, the liver, showed rapid, subset-specific transcriptional reprogramming after allogeneic hematopoietic cell transplant, with induction of canonical interferon-γ-inducible genes including interferon regulatory factor 1, MHC II, and PD-L1 in lymphatic ECs.

Targeting DDAH II with Puerarin Ameliorates Doxorubicin-Induced Endothelial Damage and Ferroptosis through ADMA/NOS Dysregulation Rescue

August 10, 2026

[Journal of Advanced Research] Scientists investigate whether Puerarin protects against doxorubicin-induced endotheliotoxicity by targeting dimethylarginine dimethylamino- hydrolase 2 (DDAHⅡ). They explored the interplay among nitric oxide signaling, autophagy, and ferroptosis in this process.

3D Co-Culture Model of Tumor Spheroid and Endothelial Cells Unveils ccRCC Aberrant Vasculature and Distinct Sensitivity to Targeted Treatments

August 10, 2026

[Angiogenesis] The authors investigated the 3D architecture of clear cell renal cell carcinoma (ccRCC) vasculature within the tumor microenvironment and its response to drugs. They defined key features and heterogeneity of ccRCC vascular architecture and highlighted ponds as candidate contributors to treatment failure and targets for future interventions.

Humacyte Announces FDA Acceptance of IND for First-In-Human Clinical Study of CTEV for Coronary Artery Bypass Grafting

July 28, 2026

[Humacyte, Inc.] Humacyte, Inc. announced that the FDA has accepted its Investigational New Drug application (IND) for a first-in-human clinical study of the coronary tissue engineered vessel (CTEV) in coronary artery bypass grafting. The CTEV is a universally implantable bioengineered human blood vessel.

LPL-Positive Endothelial Cells Control T-Cell Homing in Liver Metastasis

July 28, 2026

[Cancer Discovery] Tracing the transcriptional response of liver metastasis–associated peritumoral and tumor endothelial cells (TEC) to T cell intervention, scientists discovered an immunomodulatory TEC subpopulation that highly expressed lipoprotein lipase (LPL).

S1P Receptor 1 Signaling Reduces Arterial Thrombosis via Up-Regulation of Endothelial Thrombomodulin Expression

July 28, 2026

[Science Advances] Investigators hypothesized that sphingosine-1-phosphate (S1P) reduces platelet adhesion and thrombus formation by up-regulation of endothelial thrombomodulin. This would identify S1P as an antithrombotic target without increasing bleeding risk.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.