Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Extracellular Vesicles from UTX-Knockout Endothelial Cells Boost Neural Stem Cell Differentiation in Spinal Cord Injury

[Cell Communication And Signaling] Two mouse models were used to investigate spinal cord injury: neural stem cells lineage-traced mice and mice with conditional Ubiquitously Transcribed Tetratripeptide Repeat on Chromosome X knockout in endothelial cells.

Repurposing Disulfiram to Combat Acute Respiratory Distress Syndrome with Targeted Delivery by LET-Functionalized Nanoplatforms

[ACS Applied Materials & Interfaces] Scientists used biocompatible liposomes incorporating a lung endothelial cell-targeted peptide to produce disulfiram-loaded nanoparticles for targeted delivery and reactive oxygen species-responsive release facilitated by the inclusion of thioketal within the liposomal structure.

Anna Rita Cantelmo: When the Blood Vessel Cells Malfunction

[Inserm] Passionate about vascular biology, Anna Rita Cantelmo has always wanted to conduct high-level research. Thanks to the Atip-Avenir funding she obtained in 2021, she has already identified key biological pathways.

Anna Rita Cantelmo: When the Blood Vessel Cells Malfunction

[Inserm] Passionate about vascular biology, Anna Rita Cantelmo has always wanted to conduct high-level research. Thanks to the Atip-Avenir funding she obtained in 2021, she has already identified key biological pathways.

FGF18 Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting the NF-κB Pathway

[Respiratory Research] A mouse model of acute lung injury and HUVEC stimulated with lipopolysaccharide was established in vivo and in vitro. AAV-FGF18 and fibroblast growth factor 18 (FGF18) proteins were used in C57BL/6J mice and HUVEC, respectively.

DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling

[The Journals of Gerontology: Series A] Scientists revealed that DHCR24 expression was chronologically decreased in senescent HUVECs and the aortas of aged mice.

2-Desaza-Annomontine (C81) Impedes Angiogenesis Through Reduced VEGFR2 Expression Derived from Inhibition of CDC2-Like Kinases

[Angiogenesis] Researchers showed that C81, a derivative of the plant alkaloid annomontine previously shown to inhibit endothelial inflammation, impeded angiogenesis by inhibiting CDC2-like kinases and WNT/β-catenin signaling.

PM2.5-Induced Premature Senescence in HUVECs Through the SIRT1/PGC-1α/SIRT3 Pathway

[Science Of The Total Environment] Scientists investigated the impact of PM2.5 on vascular endothelial cell senescence and to elucidate the underlying mechanisms. Their findings revealed that PM2.5 exposure led to an increase in senescence-associated β-galactosidase activity and the expression of the cell cycle-blocking proteins P53/P21 and P16 in HUVECs.

Akt3 Activation by R-ras in an Endothelial Cell Enforces Quiescence and Barrier Stability of Neighboring Endothelial Cells via Jagged1

[Cell Reports] Investigators showed that quiescent endothelial cells use Jagged1 to instruct neighboring endothelial cells to assume a quiescent phenotype and secure the endothelial barrier.

AAV-Mediated VEGFA Overexpression Promotes Angiogenesis and Recovery of Locomotor Function Following Spinal Cord Injury via PI3K/Akt Signaling

[Experimental Neurology] Researchers investigated whether overexpression of adeno-associated virus (AAV)-mediated VEGFA in mouse spinal cord injury promoted locomotor function recovery, and whether the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway was mechanistically involved.

Designer High-Density Lipoprotein Particles Enhance Endothelial Barrier Function and Suppress Inflammation

[Science Signaling] Scientists generated a fusion protein called A1M to promote both sphingosine 1-phosphate and prostacyclin signaling. When bound to S1P or a prostacyclin analog, A1M suppressed inflammation and increased the barrier function of cultured endothelial cells.

Mechanisms of Endothelial Activation, Hypercoagulation and Thrombosis in COVID-19: A Link with Diabetes Mellitus

[Cardiovascular Diabetology] The authors provide an overview of the potential triggers of endothelial activation related to COVID-19 and COVID-19 under diabetic milieu.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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