Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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Proinflammatory Immune Cells Disrupt Angiogenesis and Promote Germinal Matrix Hemorrhage in Prenatal Human Brain

October 4, 2024

[Nature Neuroscience] Researchers showed that microglia in prenatal mouse and human brain interact with nascent vasculature in an age-dependent manner and that ablation of these cells in mice reduced angiogenesis in the ganglionic eminences, which corresponded to the human germinal matrix.

MLKL-Mediated Endothelial Necroptosis Drives Vascular Damage and Mortality in Systemic Inflammatory Response Syndrome

October 3, 2024

[Cellular & Molecular Immunology] The authors utilized visualization analysis via intravital microscopy to demonstrate that both anticoagulant heparin and nonanticoagulant heparin pretreatment protect mice against TNF-α-induced mortality in systemic inflammatory response syndrome.

Endothelial Cell Mechanics and Dynamics in Angiogenesis

October 2, 2024

[Current Opinion in Cell Biology] Investigators discuss new conceptual advances gained from in vitro and in vivo models of angiogenesis on the control of endothelial cell dynamics.

Matrix Stiffness of GelMA Hydrogels Regulates Lymphatic Endothelial Cells toward Enhanced Lymphangiogenesis

October 1, 2024

[ACS Applied Materials & Interfaces] Researchers focused on investigating how hydrogel matrix stiffness influenced lymphatic endothelial cells in promoting lymphatic vessel regeneration.

Angiotensin 1–7 Restrains Vascular Injury of Extracorporeal Membrane Oxygenation by Inhibiting Ferroptosis

September 23, 2024

Scientists hypothesized that Ang1-7 inhibited human umbilical vein endothelial cells ferroptosis through NF-κB/P53 signal pathway, and reduced extracorporeal membrane oxygenation vascular injury. [International Immunopharmacology] Abstract

Macrophages-Derived High Mobility Group Box-1 Protein Induces Endothelial Progenitor Cells Pyroptosis

September 20, 2024

[iScience] Investigators used an cell model of sepsis in vitro to isolate endothelial progenitor cells for better observation.

Arpin Deficiency Increases Actomyosin Contractility and Vascular Permeability

September 20, 2024

[eLife] Arpin depletion in human umbilical vein endothelial cells caused the formation of actomyosin stress fibers leading to increased permeability in an Arp2/3-independent manner.

JAK Inhibitors Inhibit Angiogenesis by Reducing VEGF Production from Rheumatoid Arthritis–Derived Fibroblast-Like Synoviocytes

September 20, 2024

[Clinical Rheumatology] Rheumatoid arthritis-derived fibroblast-like synoviocytes were seeded on type I collagen gel, and human umbilical vein endothelial cells were directly added.

Immunomodulation by Endothelial Cells: Prospects for Cancer Therapy

September 19, 2024

[Trends in Cancer] The authors discuss the current understanding of immunomodulatory endothelial cells in cancer biology, scrutinizing insights from single-cell reports to compare their characteristics and function dynamics across diverse tumor types, conditions, and species.

Endolysosomal Dysfunction in Radial Glia Progenitor Cells Leads to Defective Cerebral Angiogenesis and Compromised Blood-Brain Barrier Integrity

September 18, 2024

[Nature Communications] Researchers used zebrafish embryos carrying a mutation in scavenger receptor B2, a highly conserved endolysosomal protein expressed predominantly in radial glia cells, to investigate the interplay among different neurovascular unit components.

Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells

September 17, 2024

[Scientific Reports] Investigators found robust lymphangiogenesis during influenza A virus infection in the adult mouse lung. They showed that the number of lymphatic endothelial cells increased twofold at seven days post-influenza infection (dpi) and threefold at 21 dpi, and that lymphangiogenesis is preceded by lymphatic dilation.

Mulberroside a Attenuates Cigarette Smoke-Induced Atherosclerosis in ApoE−/− Mice via the Sirt1-HIF-1α Axis

September 16, 2024

[Cellular Signalling] Researchers investigated whether Mulberryside A could attenuate cigarette smoke extract-induced autophagy through a Sirt1-dependent pathway, thereby attenuating atherosclerosis in ApoE−/− mice.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.