Onco-Fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

The hepatocellular carcinoma ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages.
[Cell]
Sharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., Erdal, S., Teo, H. M., Khalilnezhad, A., Chakarov, S., Lim, T. K. H., Fui, A. C. Y., Chieh, A. K. W., Chung, C. P., Bonney, G. K., … DasGupta, R. (2020). Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.08.040 Cite
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Nanoparticle Enhanced Combination Therapy for Stem-Like Progenitors Defined by Single-Cell Transcriptomics in Chemotherapy-Resistant Osteosarcoma

Scientists utilized single-cell transcriptomics to systematically map the cell-type-specific gene expression in a chemotherapy-resistant osteosarcoma tumor.
[Signal Transduction and Targeted Therapy]
Wang, L., Huang, X., You, X., Yi, T., Lu, B., Liu, J., Lu, G., Ma, M., Zou, C., Wu, J., & Zhao, W. (2020). Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00248-x Cite
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Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis

The authors present an objective review of the key senescence-related alterations of the major intracellular organelles and analyze the role of relevant cell types for senescence and atherogenesis.
[Cells]
Machado-Oliveira, G., Ramos, C., Marques, A. R. A., & Vieira, O. V. (2020). Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis. Cells, 9(10), 2146. https://doi.org/10.3390/cells9102146 Cite
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Spatiotemporal Restriction of Endothelial Cell Calcium Signaling Is Required during Leukocyte Transmigration

Endothelial calmodulin (CaM), a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for leukocyte transendothelial migration.
[Journal of Experimental Medicine]
Dalal, P. J., Sullivan, D. P., Weber, E. W., Sacks, D. B., Gunzer, M., Grumbach, I. M., Heller Brown, J., & Muller, W. A. (2021). Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration. Journal of Experimental Medicine, 218(1). https://doi.org/10.1084/jem.20192378 Cite
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Inspired by the Human Placenta: A Novel 3D Bioprinted Membrane System to Create Barrier Models

Inspired by the human placenta scientists established a coculture of a trophoblast-derived cell line, together with primary placental fibroblasts within the biological membrane and primary human placental endothelial cells—representing three cellular components of the human placental villus.
[Scientific Reports]
Kreuder, A.-E., Bolaños-Rosales, A., Palmer, C., Thomas, A., Geiger, M.-A., Lam, T., Amler, A.-K., Markert, U. R., Lauster, R., & Kloke, L. (2020). Inspired by the human placenta: a novel 3D bioprinted membrane system to create barrier models. Scientific Reports, 10(1), 15606. https://doi.org/10.1038/s41598-020-72559-6 Cite
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Pharmacological and Cardiovascular Perspectives on the Treatment of COVID-19 with Chloroquine Derivatives

While respiratory symptoms are the major clinical manifestations, cardiovascular abnormalities, including arrhythmias, myocarditis, heart failure, and ischemic stroke, have been reported in a significant number of COVID-19 patients.
[Acta Pharmacologica Sinica]
Zhang, X., Li, Z., Ye, J., Lu, J., Ye, L. L., Zhang, C., Liu, P., & Duan, D. D. (2020). Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives. Acta Pharmacologica Sinica, 1–10. https://doi.org/10.1038/s41401-020-00519-x Cite
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Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat

Adenoviral vectors carrying genes encoding vascular endothelial growth factor, glial cell-derived neurotrophic factor and neural cell adhesion molecule or gene engineered umbilical cord blood mononuclear cells overexpressing recombinant vascular endothelial growth factor, glial cell-derived neurotrophic factor, and neural cell adhesion molecule were intrathecally injected before distal occlusion of the middle cerebral artery in rats.
[International Journal of Molecular Sciences]
Markosyan, V., Safiullov, Z., Izmailov, A., Fadeev, F., Sokolov, M., Kuznetsov, M., Trofimov, D., Kim, E., Kundakchyan, G., Gibadullin, A., Salafutdinov, I., Nurullin, L., Bashirov, F., & Islamov, R. (2020). Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat. International Journal of Molecular Sciences, 21(18), 6858. https://doi.org/10.3390/ijms21186858 Cite
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Gold Nanorod-Based Nanoplatform Catalyzes Constant NO Generation and Protects from Cardiovascular Injury

Researchers found that NanoNOS greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting NanoNOS treatment could help prevent cardiovascular diseases.
[ACS Nano]
Li, H., Yan, J., Meng, D., Cai, R., Gao, X., Ji, Y., Wang, L., Chen, C., & Wu, X. (2020). Gold Nanorod-Based Nanoplatform Catalyzes Constant NO Generation and Protects from Cardiovascular Injury. ACS Nano. https://doi.org/10.1021/acsnano.0c03629 Cite
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NLRP3 Inflammasome in Endothelial Dysfunction

The authors provide a comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms.
[Cell Death & Disease]
Bai, B., Yang, Y., Wang, Q., Li, M., Tian, C., Liu, Y., Aung, L. H. H., Li, P., Yu, T., & Chu, X. (2020). NLRP3 inflammasome in endothelial dysfunction. Cell Death & Disease, 11(9), 1–18. https://doi.org/10.1038/s41419-020-02985-x Cite
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Roche Receives Positive CHMP Opinion for Tecentriq in Combination with Avastin for the Treatment of People with the Most Common Form of Liver Cancer

Roche announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of Tecentriq® in combination with Avastin® for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have not received prior systemic therapy.
[F. Hoffmann-La Roche Ltd]
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Aerpio Announces Enrollment Completed in the 28-Day Phase II Razuprotafib Glaucoma Trial

Aerpio Pharmaceuticals, Inc. announced that it has completed patient enrollment in its double-blind, placebo-controlled Phase II trial in patients with elevated intraocular pressure associated with open angle glaucoma or ocular hypertension.
[Aerpio Pharmaceuticals, Inc.]
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