Cancer Stem Cell News
Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Subscribe|Follow Us On
Ocular Therapeutix™ Announces Positive Pre-NDA Meeting with U.S. FDA for AXPAXLI™ in Wet AMD
[Ocular Therapeutix] Ocular Therapeutix announced the successful completion of its Pre-New Drug Application Meeting with the U.S. Food and Drug Administration (FDA) for its investigational product candidate AXPAXLI™ (also known as OTX-TKI) for the treatment of wet age-related macular degeneration (wet AMD).
Targeting Super Elongation Complex-Driven RNA Polymerase II Elongation Reduces Plaque Vulnerability
[Signal Transduction and Targeted Therapy] Scientists investigated whether transcriptional pause release and RNA polymerase II elongation constitute an early regulatory layer that promotes endothelial-to-mesenchymal transition and atherosclerosis.
Oscillatory Shear Stress-Induced Endothelial Extracellular Vesicles Exacerbate Aortic Valve Calcification
[Cardiovascular Research] Using circRNA microarray sequencing, the authors identified circILRUN as the most markedly upregulated circRNA in small extracellular vesicles from oscillatory shear stress-stimulated human valvular endothelial cells.
Inflammatory Endothelium-Targeted Carbon Dot Nanozymes for Exogenous Enzyme Supplementation and Synergistic Regulation in Acute Lung Injury
[Advanced Healthcare Materials] Researchers developed a nanozyme system that targets E-selectin on inflamed endothelium and is capable of halting excessive ROS accumulation within the critical therapeutic time window in acute lung injury.
Age-Associated Loss of Lymphatic Vessels Promotes Cardiac Inflammation
[Nature Cardiovascular Research] Investigators showed that aging reduces cardiac lymphatic vessel density in humans and mice and induces structural remodeling characterized by tighter, zipper-like endothelial junctions.
Geometry-Encoded Microtrenches Stabilize Endothelium on High Shear Biomaterial Surfaces
[Acta Biomaterialia] The authors hypothesized that mesoscale surface geometry could preserve endothelial coverage and function under extreme shear. Engineered microtrenches were introduced onto an implant biomaterial to generate spatially defined shear environments.
The RAMP3 Proximity Interactor MYO6 Determines Spatiotemporal Signaling of the GPCR CLR in Lymphatic Endothelial Cells
[Science Signaling] Scientists used proximity proteomics to identify components of the receptor activity–modifying protein 3 (RAMP3) interactome that regulated calcitonin receptor-like receptor (CLR) and characterized how the interactome changed in response to the prolymphangiogenic peptide adrenomedullin.
Endothelial Cell Transcriptomics Reveal Activation of Ribosomal-Related Pathways in Chronic Thromboembolic Pulmonary Hypertension
[Archivos De Bronconeumologia] Researchers analyzed endothelial colony-forming cells derived from pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension patients and healthy-controls to identify disease-specific molecular and functional alterations.
Clozapine Impairs Angiogenic Function and Cellular Bioenergetics in Primary Human Endothelial Progenitor Cells and Zebrafish: Involvement of Aryl Hydrocarbon Receptor Signaling
[Archives of Toxicology] Investigators combined a propensity score-matched nationwide cohort of 28,802 patients with experiments in primary human endothelial progenitor cells and zebrafish embryos to study the effects of clozapine on endothelial repair and potential relevance to coronary artery disease.
Regeneration and Replacement of the Corneal Endothelium: Advances in Cell Therapy, Tissue Engineering, Molecular, and Pharmacologic Strategies
[American Journal of Ophthalmology] The authors discuss recent advances in corneal endothelial cell therapy, tissue engineering, gene- and RNA-targeted approaches, and pharmacologic therapies aimed at preserving or replacing the corneal endothelium.
Endothelial-to-Mesenchymal Transition in Ischemic Diseases: Molecular Mechanisms, Pathophysiological Roles, and Emerging Therapeutic Strategies
[Life Sciences] Scientists summarize the current understanding of endothelial-to-mesenchymal transition in ischemic diseases, focusing on the major regulatory signaling pathways and epigenetic mechanisms.
ADARx Pharmaceuticals Receives FDA Fast Track Designation for Onvuzosiran for the Treatment of HAE
[ADARx Pharmaceuticals, Inc.] ADARx Pharmaceuticals, Inc. announced that it has received Fast Track designation from the US FDA for onvuzosiran, an investigational small interfering RNA therapeutic candidate, for prophylaxis to prevent attacks of hereditary angioedema (HAE). The underlying cause of HAE is an abnormality in the kallikrein-kinin cascade resulting in increased bradykinin.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
