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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Inhibiting Endothelial Rhoj Blocks Profibrotic Vascular Intussusception and Angiocrine Factors to Sustain Lung Regeneration
[Science Translational Medicine] Researchers tested the role of N6-methyladenosine modification of forkhead box protein O1 mRNA in lung regeneration after pneumonectomy in mice, a model for lung regrowth after surgical resection.
Inducible Deletion of Endothelial Cell Efnb2 Delays Capillary Regeneration and Attenuates Myofiber Reinnervation following Myotoxin Injury in Mice
[Journal of Physiology] Scientists hypothesized that, following acute injury to skeletal muscle, loss of endothelial cell ephrin-B2 (Efnb2) would impair microvascular regeneration and the recovery of neuromuscular junction integrity.
Tropomyosin 1 Deficiency Facilitates Cell State Transitions and Enhances Hemogenic Endothelial Cell Specification during Hematopoiesis
[Stem Cell Reports] Using gene-edited induced pluripotent stem cell model systems, the authors found that tropomyosin 1 (TPM1) knockout augmented developmental cell state transitions and key signaling pathways, including tumor necrosis factor alpha signaling, to promote hemogenic endothelial cell specification and hematopoietic progenitor cell production.
A Systems View of the Vascular Endothelium in Health and Disease
[Cell] Investigators present a holistic view of the field of vascular research and review the diverse functions of blood-vessel-lining endothelial cells during the life cycle of the vasculature, namely responsive and relaying functions of the vascular endothelium and the responsive roles as instructive gatekeepers of organ function.
Brain Aneurysm Foundation Announces its 2024 Research Grant Recipients
[Brain Aneurysm Foundation (PR Newswire)] The Brain Aneurysm Foundation, the leading advocacy organization supporting education, research, and policy to transform the treatment of brain aneurysms, announced the recipients of its 2024 research grants.
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake
[Circulation Research] Responses to shear stress were analyzed using cultured porcine aortic endothelial cell (EC) exposed to flow in vitro coupled with metabolic and molecular analyses and by en face immunostaining of murine aortic EC exposed to disturbed flow in vivo.
Endothelial γ-Protocadherins Inhibit KLF2 and KLF4 to Promote Atherosclerosis
[Nature Cardiovascular Research] Investigators identified clustered γ-protocadherins as therapeutically targetable, potent KLF2 and KLF4 suppressors whose upregulation contributes to atherosclerotic cardiovascular disease.
Magnetically Integrated Tumor–Vascular Interface System to Mimic Pro-angiogenic Endothelial Dysregulations for On-Chip Drug Testing
[ACS Applied Materials & Interfaces] Researchers reported the design and development of a custom-engineered tumor–vascular interface system for investigating the early stage tumor-mediated pro-angiogenic dysfunctional behavior of the endothelium.
AQP1 Differentially Orchestrates Endothelial Cell Senescence
[Redox Biology] The authors delineated a previously unrecognized role of aquaporin 1 (AQP1) in orchestrating extracellular hydrogen peroxide-induced cellular senescence in aortic endothelial cells.
Enhanced Anti-Angiogenic Effects of Aprepitant-Loaded Nanoparticles in Human Umbilical Vein Endothelial Cells
[Scientific Reports] Cellular uptake studies demonstrated enhanced internalization of aprepitant-loaded nanoparticles by HUVEC cells compared to free aprepitant, as confirmed by fluorescence microscopy.
Scientist Who Promotes ‘Exercise as Medicine’ Awarded Prize for Trailblazing Work on Physical Activity and Diabetes
[Novo Nordisk Foundation] Professor Juleen Zierath has demonstrated the profound therapeutic potential of exercise through 30 years of research. The scientist from the Karolinska Institutet in Stockholm and the University of Copenhagen is the 2024 recipient of the Diabetes Prize for Excellence, awarded by the European Association for the Study of Diabetes and the Novo Nordisk Foundation.
$3.3 Million Study to Explore Eye Health in Patients With Prediabetes and Diabetes
[University of Houston (News-Medical.Net)] A $3.3 million study at the University of Houston College of Optometry will track the health of patients with prediabetes and diabetes to find out who might develop eye problems and be at risk for future vision loss.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
