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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Endothelial Piezo1 Stimulates Angiogenesis to Offer Protection against Intestinal Ischemia-Reperfusion Injury in Mice
[Molecular Medicine] Investigators explored the specific roles and underlying mechanisms by which endothelial Piezo1 was involved in intestinal ischemia–reperfusion injury.
Endothelial Dysfunction Drives Atherosclerotic Plaque Macrophage-Dependent Abdominal Aortic Aneurysm Formation
[Nature Immunology] Using a mouse model that combined cigarette smoke exposure and hypercholesterolemia, the authors demonstrated that cigarette smoke exacerbated atherosclerosis, leading to elastin fragmentation, aneurysm formation, rupture, and death.
CYR61 Delivery Promotes Angiogenesis during Bone Fracture Repair
[npj Regenerative Medicine] Researchers mapped the distribution of endogenous cysteine-rich angiogenic inducer 61 (CYR61) during bone repair and evaluate the effects of recombinant CYR61 delivery on vascularized bone regeneration.
Non-Enzymatic Modification of Aminophospholipids Induces Angiogenesis, Inflammation, and Insulin Signaling Dysregulation in Human Renal Glomerular Endothelial Cells In Vitro
[Free Radical Biology and Medicine] Human renal glomerular endothelial cells cells were exposed to non-enzymatically modified phosphatidylethanolamine by advanced glycation end-products, non-modified phosphatidylethanolamine, employed as a negative control, and lipopolysaccharides as a positive control.
Intussusceptive Angiogenesis-on-a-Chip: Evidence for Transluminal Vascular Bridging by Endothelial Delamination
[Proceedings of The National Academy of Sciences of The United States of America] Investigators used a microvessel-on-a-chip strategy, creating a microconduit coherently lined with flow-sensitive endothelial cells but in which transluminal bridges also formed.
Biocon Biologics Announces US FDA Approval for Jobevneâ„¢, Biosimilar Bevacizumab, Expanding Its Oncology Portfolio
[Biocon Biologics] Biocon Biologics announced that the US FDA has approved Jobevneâ„¢, a biosimilar Bevacizumab for intravenous use. JOBEVNE is a VEGF inhibitor that binds with VEGF and blocks the interaction with its receptors to prevent angiogenesis.
NexThera Completes First Patient Enrollment in US Clinical Trial for ‘NT-101,’ an Eye Drop Treatment for Wet AMD
[NexThera Co., Ltd. (BioSpace)] NexThera Co., Ltd. announced that it has completed the first patient enrollment for its Phase I/IIa clinical trial of NT-101, a novel eye drop treatment for wet AMD, at a clinical trial site in Pennsylvania.
ICAM-1/CD18-Mediated Sequestration of Parasitized Phagocytes in Cortical Capillaries Promotes Neuronal Colonization by Toxoplasma gondii
[Nature Communications] Scientists investigated the mechanisms of blood-brain barrier traversal by T. gondii and T. gondii-infected leukocytes, using intracarotid arterial delivery into the cerebral circulation of mice.
Single-Cell and Spatial Transcriptomics Reveals the Key Role of MCAM+ Tip-Like Endothelial Cells in Osteosarcoma Metastasis
[NPJ Precision Oncology] Researchers constructed a single-cell atlas of endothelial cells (ECs) using single-cell transcriptomic data. It was found that tip-like ECs were abundant in the primary tumors and metastatic foci.
FLT1-Enriched Extracellular Vesicles Induce a Positive Feedback Loop between Nasopharyngeal Carcinoma Cells and Endothelial Cells to Promote Angiogenesis and Tumor Metastasis
[Oncogene] Investigators revealed that FLT1-enriched extracellular vesicles induced a positive feedback loop between nasopharyngeal carcinoma cells and endothelial cells to promote tumor angiogenesis and tumor metastasis.
Lycopene Attenuates Trimethylamine-N-Oxide-Induced Senescence in Endothelial Progenitor Cells via the AMPK/SIRT1 Pathway
[Clinical and Experimental Hypertension] Researchers hypothesized that lycopene could mitigate trimethylamine-N-oxide-induced endothelial progenitor cells senescence, with involvement of the AMPK/SIRT1 pathway.
Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds
[ACS Nano ] Vascular endothelial growth factor plasmids-loaded macrophage exosomes were fabricated and enfolded in injectable self-healing hydrogels for programmed therapy of diabetic wounds through sequentially intrinsically modulating the inflammatory microenvironment and promoting angiogenesis.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
