Category Archives: Endothelial Cell

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Endothelial Glycocalyx and Microvascular Perfusion Are Associated with Carotid Intima-Media Thickness and Impaired Myocardial Deformation in Psoriatic Disease

Researchers evaluated endothelial glycocalyx barrier properties and microvascular perfusion in psoriatic patients, as well as their correlation with carotid intima-media thickness and markers of left ventricular myocardial deformation.

[Journal of Human Hypertension]

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Melanoma-Derived Small Extracellular Vesicles Induce Lymphangiogenesis and Metastasis through an NGFR-Dependent Mechanism

Scientists found that small extracellular vesicles derived from metastatic melanoma cell lines were enriched in nerve growth factor receptor, spread through the lymphatic system and were taken up by lymphatic endothelial cells, reinforcing lymph node metastasis.

[Nature Cancer]

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Vitexin Inhibits APEX1 to Counteract the Flow-Induced Endothelial Inflammation

The authors demonstrated that vitexin, a natural flavonoid, could inhibit the activation of apurinic/apyrimidinic endonuclease1 (APEX1) to protect vascular endothelium against the adverse effects of atherogenic stimuli.

[Proceedings of the National Academy of Sciences of the United States of America]

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Lymph Node Formation and B Cell Homeostasis Require IKK-α in Distinct Endothelial Cell–Derived Compartments

Investigators revealed that IκB kinase (IKK)-α in distinct endothelial cell (EC)-derived compartments was uniquely required to promote B cell homeostasis and lymph node (LN) development, and they established that lymphatic EC-intrinsic IKK-α was absolutely essential for LN formation.

[Proceedings of the National Academy of Sciences of the United States of America]

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Pseudogene RPL32P3 Regulates the Blood–Tumor Barrier Permeability via the YBX2/HNF4G Axis

Researchers identified that ribosomal protein L32 pseudogene 3 (RPL32P3) was highly expressed in glioma-exposed endothelial cells. Knockdown of RPL32P3 decreased the expression of tight junction-related proteins and increased blood–tumor barrier permeability.

[Cell Death Discovery]

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Review

Castleman Disease

VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.

[Nature Reviews Disease Primers]

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Staphylococcus aureus Iron-Regulated Surface Determinant B (IsdB) Protein Interacts with Von Willebrand Factor and Promotes Adherence to Endothelial Cells

The binding of IsdB and adhesion of Staphylococcus aureus expressing IsdB to monolayers of activated endothelial cells was significantly inhibited by a monoclonal antibody against the A1 domain and by IsdB reactive IgG from patients with staphylococcal endocarditis.

[Scientific Reports]

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Receptor Interacting Protein 3 Kinase, Not 1 Kinase, through MLKL-Mediated Necroptosis Is Involved in UVA-Induced Corneal Endothelium Cell Death

The authors investigated receptor-interacting protein 3 kinase, a key signaling molecule of programmed cell death, in UVA-induced injury using a short-term corneal endothelium culture model.

[Cell Death Discovery]

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Insulin-Stimulated Adipocytes Secrete Lactate to Promote Endothelial Fatty Acid Uptake and Transport

Investigators modeled the relationship of adipocytes and endothelial cells in vitro to test the role of insulin in fatty acid transport.

[Journal of Cell Science]

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The Effect of Endocrine Disrupting Chemicals on the Vitronectin-Receptor (Integrin αvβ3)-Mediated Cell Adhesion of Human Umbilical Vein Endothelial Cells

Vitronectin receptor (VTNR)-expressing HUVECs were used to determine the effects of endocrine disrupting chemicals and endogenous hormones on cell adhesion to vitronectin-coated surfaces, and on VTNR activation.

[Toxicology in Vitro]

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