CFTR Limits F-Actin Formation and Promotes Morphological Alignment with Flow in Human Lung Microvascular Endothelial Cells

Investigators tested the hypothesis that the cystic fibrosis transmembrane conductance regulator regulated endothelial actin cytoskeleton dynamics and cellular alignment in response to flow.
[physiological reports]
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The Impact of Fine Particulate Matter (PM) on Various Beneficial Functions of Human Endometrial Stem Cells through Its Key Regulator SERPINB2

Scientists showed that PM exposure significantly inhibited various beneficial functions of endometrial stem cells, such as their self-renewal, transdifferentiation, and migratory capacities, in vitro and in vivo through the PM target gene SERPINB2, which has recently been shown to be involved in multiple stem cell functions.
[Experimental and Molecular Medicine]
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Endothelial Deletion of SHP2 Suppresses Tumor Angiogenesis and Promotes Vascular Normalization

SHP2 inefficiency impaired endothelial cell proliferation, migration, and tubulogenesis through downregulating the expression of proangiogenic SRY-Box transcription factor 7 (SOX7), whose re-expression restored endothelial function in SHP2-knockdown cells and tumor growth, angiogenesis, and vascular abnormalization in Shp2-deleted mice.
[Nature Communications]
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Lymphangion-Chip: A Microphysiological System Which Supports Co-Culture and Bidirectional Signaling of Lymphatic Endothelial and Muscle Cells

A fabrication technique was developed to create a lymphangion-chip. This organ-on-chip consisted of co-culture of a monolayer of endothelial lumen surrounded by multiple and uniformly thick layers of muscle cells.
[Lab On A Chip]
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CRISPR/Cas9-Engineered HLA-Deleted Glomerular Endothelial Cells as a Tool to Predict Pathogenic Non-HLA Antibodies in Kidney Transplant Recipients

The authors designed a non-human leukocyte antigen (HLA) antibody detection immunoassay using HLA class I and II–deficient glomerular endothelial cells that had been previously generated through CRISPR/Cas9-induced B2M and CIITA gene disruption.
[Journal of the American Society of Nephrology]
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NOX1 Mediates Metabolic Heart Disease in Mice and Is Upregulated in Monocytes of Humans with Diastolic Dysfunction

NOX1 mediated endothelial activation and contributed to myocardial inflammation and remodeling in metabolic disease in mice. Given its high expression in monocytes of humans with diastolic dysfunction (DD), NOX1 may represent a potential target to mitigate heart disease associated with DD.
[Cardiovascular Research]
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Neuropilin 1 Regulates Bone Marrow Vascular Regeneration and Hematopoietic Reconstitution

Researchers reported that bone marrow (BM) vascular endothelial cells secreted semaphorin 3 A (SEMA3A) in response to myeloablation and SEMA3A induced p53 – mediated apoptosis in BM endothelial cells via signaling through its receptor, Neuropilin 1 (NRP1), and activation of cyclin dependent kinase 5.
[Nature Communications]
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Bone Marrow Sinusoidal Endothelium Controls Terminal Erythroid Differentiation and Reticulocyte Maturation

Scientists showed that bone marrow sinusoidal endothelial cells (BM-SEC) actively controlled erythropoiesis. While activation of Wnt-signaling in BM-SEC caused an increase in erythroblast subsets, mature erythroid cells were reduced, indicating impairment of terminal erythroid differentiation/reticulocyte maturation.
[Nature Communications]
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Low-Flow Intussusception and Metastable VEGFR2 Signaling Launch Angiogenesis in Ischemic Muscle

Endothelial cells subjected to ultralow shear stress could reposition inside the flowing lumen as pillars. Moreover, the low-flow lumen proved to be a privileged location for endothelial cells with reduced vascular endothelial growth factor receptor-2 (VEGFR2) signaling capacity, as VEGFR2 mechanosignals were boosted.
[Science Advances]
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Adenoviral VEGF-B186R127S Gene Transfer Induces Angiogenesis and Improves Perfusion in Ischemic Heart

Investigators cloned VEGF-B isoforms with different receptor binding profiles to clarify the roles of VEGFR-1 and Nrp-1 in angiogenesis and to see if angiogenic properties could be maintained while avoiding side effects.
[iScience]
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Bone Morphogenetic Protein 9 Enhances Osteogenic and Angiogenic Responses of Human Amniotic Mesenchymal Stem Cells Cocultured with Umbilical Vein Endothelial Cells through the PI3K/AKT/M-TOR Signaling Pathway

The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells (hAMSCs) cocultured with human umbilical vein endothelial cells (HUVECs) and determined the possible underlying molecular mechanism.
[Aging]
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