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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
MT2A Promotes Angiogenesis in Chronically Ischemic Brains through a Copper–Mitochondria Regulatory Mechanism
[Journal of Translational Medicine] The authors collected dura matter samples from chronic ischemic cerebrovascular disease patients and examined the expression of cuproptosis-related genes to confirm the inhibitory effect of copper overload on angiogenesis.
Loss of Endothelial TRPC1 Induces Aortic Hypercontractility and Hypertension
[Circulation Research] The authors generated endothelial-specific transient receptor potential channel canonical family member 1 (TRPC1)-deficient and knockin mice and analyzed their changes in vascular function under physiological and pathologically obese state.
Endothelial Cell pY397-FAK Expression Predicts Risk of Breast Cancer Recurrences after Radiotherapy in SweBCG91-RT Cohort
[Clinical Cancer Research] Researchers tested the interaction between endothelial cell expression of phospho-Tyr397-FAK (pY397-FAK) and adjuvant-RT on clinical outcomes after breast-conserving surgery within a randomised study.
Endothelial SHANK3 Regulates Tight Junctions in the Neonatal Mouse Blood-Brain Barrier through β-Catenin Signaling
[Nature Communications] Scientists reported that SHANK3, an autism spectrum disorder-risk gene, expressed in the blood-brain barrier (BBB)-forming brain endothelial cells and regulated tight junctional integrity essential for BBB’s barrier function.
Single-Cell Atlas of Human Pancreatic Islet and Acinar Endothelial Cells in Health and Diabetes
[Nature Communications] The authors developed strategies to enrich islet-specific endothelial cells and acinar-specific endothelial cells from three human pancreases and corroborate these findings with three published pancreatic datasets.
CircRNAs Increase during Vascular Cell Differentiation and Are Biomarkers for Vascular Disease
[Cardiovascular Research] Using high-throughput RNA sequencing and a de novo circRNA detection pipeline, investigators quantified the daily levels of 31,369 circRNAs in a two-week differentiation trajectory from human stem cells to proliferating mesoderm progenitors to quiescent, differentiated endothelial cell and smooth muscle cell.
Endothelial AGGF1 Promotes Retinal Angiogenesis by Coordinating TNFSF12/FN14 Signaling
[Nature Communications] The authors confirmed that angiogenic factor 1 with a G patch and FHA domain (AGGF1) was elevated in the diabetics and induces retinal angiogenesis.
Translational Regulation of SND1 Governs Endothelial Homeostasis During Stress
[Journal of Clinical Investigation] Researchers identified staphylococcal nuclease and tudor domain–containing protein 1 (SND1) as a sunitinib-dependent translationally repressed gene. SND1 translational repression was mediated by the mTORC1/4E-BP1 pathway.
Preservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women
[Circulation] Investigators measured endothelial function in age-matched late- and normal-onset postmenopausal women and a young premenopausal reference group.
Merck Announces Decision to Stop Phase III HYPERION Trial Evaluating WINREVAIRâ„¢ (sotatercept-csrk) Early and Move to Final Analysis
[Merck] Merck announced the Phase III HYPERION study evaluating WINREVAIR versus placebo in recently diagnosed adults with pulmonary arterial hypertension functional class II or III at intermediate or high risk of disease progression will be stopped early.
LDHA-Mediated Glycolysis in Stria Vascularis Endothelial Cells Regulates Macrophages Function through CX3CL1-CX3CR1 Pathway in Noise-Induced Oxidative Stress
[Cell Death & Disease] The authors investigated the effects of glycolysis on stria vascularis (SV)-endothelial cells in vitro and on the SV in vivo.
Loss of Endothelial CD2AP Causes Sex-Dependent Cerebrovascular Dysfunction
[Neuron] Researchers showed that loss of CD2-associated protein (CD2AP) in cerebral blood vessels was associated with cognitive decline in Alzheimer's disease subjects and that genetic downregulation of CD2AP in brain vascular endothelial cells impaired memory function in male mice.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
