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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
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Valitor Presents Preclinical Data Demonstrating VLTR-559 Achieves Superior Durability and Sustained Anti-VEGF Activity with a Favorable Safety Profile as a Treatment for Wet AMD
[Valitor] Valito announced new preclinical data demonstrating that VLTR-559, a long-acting anti-VEGF biologic designed to enable twice-yearly dosing for the treatment of wet age-related macular degeneration (AMD), achieved its preclinical durability and safety targets compared with approved short-acting anti-VEGF therapies for wet AMD.
Site-1 Protease-Mediated Cholesterol Metabolism Is Essential for Lymphatic Development in Mice
[JCI Insight] Investigators generated mice with pan-endothelial or lymphatic endothelial cells-specific deficiency of either site-1 protease (S1P) or sterol regulatory element-binding proteins 2. Mouse embryos with pan-endothelial deletion of S1P showed defective lymphatic vessel migration in skin and lymphedema, while their blood vasculature formation was relatively normal.
Long-Pulsed 1064-Nm Neodymium: Yttrium-Aluminum-Garnet Laser Alleviates Rosacea by Improving Lymphatic Vessel Dysfunction
[Inflammation Research] Researchers investigated potential lymphatic vessel abnormalities associated with rosacea and elucidate effective rosacea treatment mechanism using long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser.
DEAD-Box Helicase DDX24 Is Essential for Endothelial Mitochondrial Function to Maintain the Blood-Brain Barrier
[Cell Reports] Researchers uncovered a pivotal role for DDX24 in regulating the blood-brain barrier (BBB) via mediating mitochondrial function in endothelial cells, providing a potential therapeutic target for treating BBB-related diseases.
The Pioneer Factor, ETV2, Regulates Networks to Specify the Embryonic Endothelial Lineage
[Cardiovascular Research] Investigators uncovered the transcriptional and epigenetic changes orchestrated by ETV2 to promote the hematoendothelial lineage while suppressing other mesodermal lineages.
STK32C Activated IL-6/JAK2/STAT3 Signaling and Promoted Tumor Angiogenesis
[British Journal of Cancer] STK32C acted as a pro-angiogenic driver in colorectal cancer by activating IL-6/JAK2/STAT3 signaling via STAT3 Thr196 phosphorylation.
APOA1 Binding Protein Promotes Lymphatic Cell Fate and Lymphangiogenesis by Relieving Caveolae-Mediated Inhibition of VEGFR3 Signaling
[Nature Communications] Scientists identified APOA1 binding protein as a key regulator that promotes lymphatic endothelial cell fate specification and lymphangiogenesis.
CCL28 Contributes to Angiogenesis and Cardiac Repair through CCR10+ Endothelial Cells after Myocardial Infarction in Male Mice
[Nature Communications] The authors investigated the role of CCL28 in angiogenesis during ischemic heart disease in male mice using the myocardial infarction and hindlimb ischemia models.
A Non-Canonical Aryl Hydrocarbon Receptor Pathway Authorizes and Safeguards Clinical-Scale Expansion of Functional Human Endothelial Cells
[Nature Cardiovascular Research] The authors identified a non-canonical aryl hydrocarbon receptor pathway switched on by canonical AHR inhibitors that reactivates quiescent endothelial cell proliferation.
Dynamic Modulation of the Blood-Brain Barrier in the Healthy Brain
[Nature Reviews Neuroscience] Scientists examine the dynamic modulation of BBB function during physiological conditions and the hypothesis that such modulation contributes directly to neural and glial plasticity.
Endothelial Specialization and Angiocrine Factors Are Critical for Vascularized Organoid Models
[Cell Reports] Vascularized organoids will provide a new capability to test the importance of angiocrine interactions, which can be challenging to disentangle from their impacts on perfusion or substrate provision in vivo.
TGF-β1-Triggered Maladaptive Bone Marrow Endothelium Impedes Hematopoietic Recovery
[Signal Transduction and Targeted Therapy] In vitro experiments combined with a mouse model with adeno-associated virus-mediated bone marrow endothelial cell (BM EC)-specific overexpression of constitutively active TGF-βRI demonstrated that TGF-β1 activation drives maladaptive BM ECs.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
