Endothelial-Derived Extracellular microRNA-92a Promotes Arterial Stiffness by Regulating Phenotype Changes of Vascular Smooth Muscle Cells

The authors investigated the role of endothelial-derived extracellular microRNA-92a in promoting arterial stiffness by regulating endothelial cell–vascular smooth muscle cell communication.
[Scientific Reports]
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Engineered Human Blood–Brain Barrier Microfluidic Model for Vascular Permeability Analysis

The authors described an in vitro model of the human blood–brain barrier self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes.
[Nature Protocols]
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CU06-1004 Enhances Vascular Integrity and Improves Cardiac Remodeling by Suppressing Edema and Inflammation in Myocardial Ischemia–Reperfusion Injury

Investigators found that CU06-1004, as a vascular leakage blocker, could improve cardiac function by inhibiting cardiac microvascular endothelial cells’ hyperpermeability and subsequently reducing the neutrophil’s plugging and infiltration in infarcted hearts.
[Experimental and Molecular Medicine]
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FSAP Aggravated Endothelial Dysfunction and Neurological Deficits in Acute Ischemic Stroke Due to Large Vessel Occlusion

To screen the potential biomarkers of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), proteomic analysis was performed to identify those distinct plasma protein profiles in AIS due to LVO with different collateral status.
[Signal Transduction and Targeted Therapy]
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Large-Vessel Vasculitis

Scientists highlight the substantial heterogeneity present within large-vessel vasculitis and the importance of an individualized therapeutic approach.
[Nature Reviews Disease Primers]
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Vasculopathy in COVID-19

The authors address the vasculopathy of COVID-19 with a focus on the role of the endothelium in orchestrating the systemic response to SARS-CoV-2 infection.
[Blood]
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Robust Genome Editing in Adult Vascular Endothelium by Nanoparticle Delivery of CRISPR-Cas9 Plasmid DNA

A single intravenous administration of mixture of nanoparticles and plasmid DNA expressing Cas9 controlled by CDH5 promoter and guide RNA induced highly efficient genome editing in endothelial cells of the vasculatures, including lung, heart, aorta, and peripheral vessels in adult mice.
[Cell Reports]
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miR-125a-5p Attenuates Macrophage-Mediated Vascular Dysfunction by Targeting Ninjurin1

Researchers investigated the role of Ninj1 in physiological and pathological conditions and developed a strategy to regulate Ninj1 using specific miRNAs under pathological conditions.
[Cell Death & Differentiation]
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High Content Image Analysis to Study Phenotypic Heterogeneity in Endothelial Cell Monolayers

Scientists developed an endothelial cell (EC) profiling tool (ECPT) to examine individual cells within intact monolayers. They used ECPT to characterize different phenotypes in arterial, venous and microvascular EC populations.
[Journal of Cell Science]
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Researchers Awarded Grant to Study New Method of Islet Transplantation

Weill Cornell Medicine researchers have received a two-year $500,000 grant from JDRF to evaluate an innovative approach to islet cell transplantation, an experimental treatment for difficult-to-control type 1 diabetes.
[Weill Cornell Medicine]
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Topical Application of TAK1 Inhibitor Encapsulated by Gelatin Particle Alleviates Corneal Neovascularization

Scientists demonstrated that transforming growth factor-β-activated kinase 1 (TAK1) played an important role in the pathogenesis of corneal neovascularization.
[Theranostics]
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