Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Infected Diabetic Wound Regeneration Using Peptide-Modified Chiral Dressing to Target Revascularization

[ACS Nano] Scientists designed chiral gel dressing is fabricated (named as HA-LM2-RMR), which consistws of l-phenylalanine and cationic hexapeptide coassembled helical nanofibers cross-linked with hyaluronic acid via hydrogen bonding.

An IGFBP7high Endothelial Cell Subset Drives T Cell Extravasation in Psoriasis via Endothelial Glycocalyx Degradation

[Journal Of Clinical Investigation] Focusing on the pathogenic role of skin endothelial cells (ECs) in psoriasis, investigators characterized the molecular and functional heterogeneity of skin ECs from healthy individuals and psoriasis patients at the single-cell level.

Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage

[Advanced Science] Using live-cell imaging and correlative light and electron microscopy, it was demonstrated that membrane injury triggered a previously unknown exocytosis of early endosomes that was induced by Ca2+ entering through the wound.

CD45 Is Sufficient to Initiate Endothelial-to-Mesenchymal Transition in Human Endothelial Cells

[Arteriosclerosis Thrombosis And Vascular Biology] Scientists activated the endogenous CD45 promoter in human endothelial colony forming cells using CRISPR/inactive Cas9 transcriptional activation.

Endothelial DLL4 Is an Adipose Depot–Specific Fasting Sensor Regulating Fatty Acid Fluxes

[Arteriosclerosis Thrombosis And Vascular Biology] Researchers combined transcriptional analysis of native human adipose tissue microvascular endothelial cells (AT-EC) together with in vitro approaches in primary human AT-EC and in vivo and ex vivo studies of mice under fed and fasted conditions.

Serum Amyloid A and Interleukin -1β Facilitate LDL Transcytosis across Endothelial Cells and Atherosclerosis via NF-κB/Caveolin-1/Cavin-1 Pathway

[Atherosclerosis] Effects of serum amyloid A and IL-1β on transcytosis of low density lipoprotein (LDL) were measured by an in vitro LDL transcytosis model. NF-κB/caveolin-1/cavin-1 pathway activation was investigated by Western blots and ELISA.

Inflammatory Stimuli Induce Shedding of Heparan Sulfate from Arterial but Not Venous Porcine Endothelial Cells Leading to Differential Proinflammatory and Procoagulant Responses

[Scientific Reports] Using a 3D round-channel microfluidic system, the authors investigated the endothelial glycocalyx, particularly heparan sulfate, on porcine arterial and venous endothelial cells.

Exosome-Transmitted miR-29a Induces Colorectal Cancer Metastasis by Destroying the Vascular Endothelial Barrier

[Carcinogenesis] In vitro co-culture investigations further revealed that epithelial mesenchymal transition cancer cells released exosomal miR-29a, which altered vascular endothelial permeability.

Notch Pathways Regulate Expression of Angiostatic Factor Activin A in Endothelial – Pericyte-like Mesenchymal Stromal Cell Interactions

[Stem Cells And Development] Contributions of notch signaling pathways were evaluated in endothelial cell (EC)-adipose mesenchymal stem/stromal cell (ASC) co-cultures.

EPAS1 Resistance to miRNA-Based Regulation Contributes to Prolonged Expression of HIF-2 during Hypoxia in Human Endothelial Cells

[Gene] Scientists tested 23 microRNA that were predicted to interact with the EPAS1 transcript,18 of which were induced during prolonged hypoxia, and demonstrated that none of them were functional in vitro.

CD109-Regulated Mechanical Properties of Endothelial Cells

[Cytoskeleton] Researchers investigated the effect of the immobilization of CD109 antigen with specific antibodies on nanomechanical properties of human umbilical endothelial cells using atomic force microscopy in quantitative nanomechanical property mapping mode.

The Role of the Blood–Brain Barrier during Neurological Disease and Infection

[Biochemical Society Transactions] The authors evaluate and summarize some of the latest research on the role of the blood-brain barrier (BBB) during neurological disease and infection with a focus on the effects of inflammation and flow disturbances on the BBB.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.