Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling

[The Journals of Gerontology: Series A] Scientists revealed that DHCR24 expression was chronologically decreased in senescent HUVECs and the aortas of aged mice.

2-Desaza-Annomontine (C81) Impedes Angiogenesis Through Reduced VEGFR2 Expression Derived from Inhibition of CDC2-Like Kinases

[Angiogenesis] Researchers showed that C81, a derivative of the plant alkaloid annomontine previously shown to inhibit endothelial inflammation, impeded angiogenesis by inhibiting CDC2-like kinases and WNT/β-catenin signaling.

PM2.5-Induced Premature Senescence in HUVECs Through the SIRT1/PGC-1α/SIRT3 Pathway

[Science Of The Total Environment] Scientists investigated the impact of PM2.5 on vascular endothelial cell senescence and to elucidate the underlying mechanisms. Their findings revealed that PM2.5 exposure led to an increase in senescence-associated β-galactosidase activity and the expression of the cell cycle-blocking proteins P53/P21 and P16 in HUVECs.

Akt3 Activation by R-ras in an Endothelial Cell Enforces Quiescence and Barrier Stability of Neighboring Endothelial Cells via Jagged1

[Cell Reports] Investigators showed that quiescent endothelial cells use Jagged1 to instruct neighboring endothelial cells to assume a quiescent phenotype and secure the endothelial barrier.

AAV-Mediated VEGFA Overexpression Promotes Angiogenesis and Recovery of Locomotor Function Following Spinal Cord Injury via PI3K/Akt Signaling

[Experimental Neurology] Researchers investigated whether overexpression of adeno-associated virus (AAV)-mediated VEGFA in mouse spinal cord injury promoted locomotor function recovery, and whether the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway was mechanistically involved.

Designer High-Density Lipoprotein Particles Enhance Endothelial Barrier Function and Suppress Inflammation

[Science Signaling] Scientists generated a fusion protein called A1M to promote both sphingosine 1-phosphate and prostacyclin signaling. When bound to S1P or a prostacyclin analog, A1M suppressed inflammation and increased the barrier function of cultured endothelial cells.

Mechanisms of Endothelial Activation, Hypercoagulation and Thrombosis in COVID-19: A Link with Diabetes Mellitus

[Cardiovascular Diabetology] The authors provide an overview of the potential triggers of endothelial activation related to COVID-19 and COVID-19 under diabetic milieu.

China Conducts First Nationwide Review of Retractions and Research Misconduct

[Nature] Chinese universities are days away from the deadline to complete a nationwide audit of retracted research papers and probe of research misconduct. By 15 February, universities must submit to the government a comprehensive list of all academic articles retracted from English- and Chinese-language journals in the past three years.

Human Lens Epithelial-Secreted Exosomes Attenuate Ocular Angiogenesis via Inhibiting Microglial Activation

[Experimental Eye Research] After incubation with lens epithelial cell-secreted exosome-treated BV2 cells, hUVECs were collected for further evaluation using tube formation, Transwell assays, and 5-ethynyl-2′-deoxyuridine assays.

Quemeiteng Granule Relieves Goiter by Suppressing Thyroid Microvascular Endothelial Cell Proliferation and Angiogenesis via miR-217-5p-Mediated Targeting of FGF2-Induced Regulation of the ERK Pathway

[Journal Of Ethnopharmacology] Scientists investigated the therapeutic effects of Quemeiteng granule on goiter and the downstream regulatory mechanisms. The viability of rat thyroid microvascular endothelial cells and human thyroid microvascular endothelial cells was assessed using the CCK-8 assays.

An Antitumor Arabinan from Glehnia littoralis Activates Immunity and Inhibits Angiogenesis

[International Journal Of Biological Macromolecules] GLP90–2 suppressed angiogenesis in the transgenic zebrafish model, and this impact may be ascribed to the modulation of the VEGF/VEGFR-2 signaling pathway.

Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution

[Circulation Research] Researchers used droplet-based single-cell RNA sequencing and multiplexed error-robust fluorescence in situ hybridization to define endothelial cells (EC) and EC progenitor subtypes from E9.5, E12.5, and E15.5 mouse embryos.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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