Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Subscribe|Follow Us On

Procr+ Endothelial Progenitor Cells Govern Hematopoiesis through Fine-Tuning Mesenchymal Stem Cell Niche Signals

May 12, 2026

[Blood] Scientists identified a subset of Procr+ endothelial cells (ECs) with progenitor-like properties in bone marrow. Procr binds HSPA8 to promote Foxc2 nuclear translocation, upregulating Dll4 transcription to sustain Dll4/Notch3 activation in MSCs, revealing a Procr/HSPA8/Foxc2/Dll4 axis essential for EC and MSC crosstalk.

CreER Activation Transiently Disrupts Angiogenesis by Reducing Proliferation and Promoting Apoptosis in Vascular Endothelial Cells

May 8, 2026

[Angiogenesis] Scientists demonstrated that ubiquitous CreER activation in postnatal mice decreases body growth and impairs retinal angiogenesis. They further showed that CreER activation slows endothelial cell proliferation and promotes apoptosis concomitant with p21/CDKN1A upregulation in the angiogenic retina.

Engineering and Integrating Blood Vessel Organoids: A Comprehensive Blueprint for Physiological and Disease Modeling

May 8, 2026

[Stem Cell Reviews and Reports] The authors sumarize methods for in vitro blood vessel generation and explore how vascularizing parenchymal organoids actively drives tissue maturation while overcoming hypoxic limitations.

Critical Path Institute Awards $456,000 Grant to Advance Next-Generation Therapy for Rare Glycolipid Storage Disorders

May 4, 2026

[Critical Path Institute^® ] Critical Path Institute® announced a $456,000 grant to Dr. James Shayman at the University of Michigan, to support development of a brain-penetrant therapy for glycosphingolipid storage disorders.

Researchers Urge Providers to Consider Regimen for Patients Whose Tumors Harbor Specific Mutations

May 4, 2026

[UC News] Researchers at the University of Cincinnati (UC) Gardner Neuroscience Institute’s Brain Tumor Center have been confirmed as the first in the world to achieve complete remission of a rare pituitary cancer using a novel immunotherapy treatment.

A Human Endothelial and Adipose Stem Cell-Based Co-Culture Model for Venous Malformations

May 4, 2026

[Angiogenesis] Researchers reported on an advanced in vitro model for recapitulating cellular and molecular pathologies of the venous malformations-causative TIE2L914F mutation by co-culturing human adipose tissue-derived stem cells with either human umbilical vein endothelial cells (ECs) retrovirally transduced to express TIE2L914F or with iPSC-derived ECs with locus-targeted TIE2L914F.

ERG Is a Regulator of Dynamic and Reversible Endothelial Plasticity

May 4, 2026

[Genome Medicine] Scientists investigated the role of endothelial-enriched transcription factor E-26 transformation specific (ETS)-related gene (ERG) in maintaining endothelial identity by examining dynamic changes in endothelial cell chromatin accessibility and transcriptional landscapes and their impact on endothelial phenotypes and function following ERG loss.

A Viscous DES-AAV-Foxo1 Delivery System with High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria-ER Contacts

May 4, 2026

[Advanced Science] The authors engineered an AAV-Foxo1 delivery system using a choline chloride-fructose-based deep eutectic solvent (DES) as the carrier. The DES-AAV-Foxo1 delivery system exhibited good biocompatibility, prolonged anterior chamber retention, and enhanced transfection efficiency in corneal endothelial cells compared to conventional AAV delivery.

Purine Metabolic Adaptation Protects the Endothelium from Disturbed Flow-Induced DNA Damage and Atherosclerosis

May 4, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase-mediated de novo purine synthesis as a flow-responsive metabolic program that safeguards endothelial cell barrier function at atheroprone sites.

Differential Properties of NS1 Glycoproteins in West Nile and Usutu Viruses

May 1, 2026

[Emerging Microbes & Infections] Researchers combined in vitro, in vivo, and clinical approaches to compare NS1 secretion, stability, and its impact on blood-brain barrier. Their results showed that West Nile virus nonstructural protein 1 (NS1) is secreted at significantly higher levels, exhibits greater thermal stability, and disrupts brain endothelial barrier integrity in vitro.

GPR124 Regulates Hyaloid Blood Vessel Regression and Is Associated with Endothelial-Mesenchymal Transition

May 1, 2026

[Scientific Reports] Investigators identified GPR124, a ligand-specific co-receptor for WNT7A/B, as a key regulator of hyaloid vessel regression. GPR124 function in the developing eye was highly compartment-specific: although crucial for hyaloid vessel regression, it was dispensable for retinal angiogenesis, despite being expressed in both vascular beds

Endothelial Activation and Damage Associated with Steroid-Refractory aGVHD Is Counteracted by Ruxolitinib

May 1, 2026

[Blood Advances] Researchers characterized the endothelial damage phenotype induced by steroid-refractory acute graft-versus-host disease (SR-aGVHD) serum and evaluated the potential modulatory effects of ruxolitinib.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.