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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Endothelial Plasticity in Atrial Fibrosis by Integrating Single-Cell Sequencing and Genetic Lineage Tracing
[European Heart Journal] Scientists identified endothelial cells as predominant signal-sending cells with extensive fibroblasts connectivity in both sinus rhythm and atrial fibrillation atrial tissues.
Endothelial Sensitivity to Pro-Fibrotic Signals Links Systemic Exposure to Pulmonary Fibrosis
[Cell Death & Disease] Researchers investigated early transcriptomic and secretory responses of HUVECs to subtoxic doses of bleomycin, a known pro-fibrotic agent, and TGF-beta, a key cytokine in fibrosis.
Iridex Announces First Patient Enrolled in an Independent Landmark Investigator-Led UK Study Evaluating MicroPulse® Technology as an Adjunct to anti-VEGF Therapy for Diabetic Macular...
[Iridex Corporation (BioSpace)] Iridex Corporation announced that the first patient has been enrolled in the investigator-led DAME Trial to evaluate the clinical efficacy, safety, cost-effectiveness, and patient acceptability of adding subthreshold MicroPulse treatments to anti-vascular endothelial growth factor therapy in patients presenting with severe diabetic macular edema.
Blood‑Brain Barrier Dysfunction in Epilepsy: Mechanisms, Therapeutic Strategies, and Future Orientation
[International Journal of Molecular Medicine] The authors review the critical role of the blood-brain barrier (BBB) in the pathogenesis of epilepsy, untangle the complex association between BBB dysfunction and the course of the disease, and explore new approaches for epilepsy prevention and treatment from a BBB perspective.
TGF-β Inhibition Restores Hematopoiesis and Immune Balance via Bone Marrow EPCs in Aplastic Anemia
[Experimental & Molecular Medicine] Scientists find that transforming growth factor-β (TGF-β) signaling is hyperactive in dysfunctional aplastic anemia endothelial progenitor cells (EPCs) with impaired hematopoietic support and immune regulatory ability, and TGF-β inhibition promotes hematopoiesis and immune rebalance by repairing dysfunctional EPCs.
Vamp3/Syntaxin 4 Mediates the Basolateral Membrane Fusion of TfR Transcytosis across the BBB and Is Exploited by Pathogenic E. coli
[Proceedings of The National Academy of Sciences of The United States of America] Investigators found that the interaction between VAMP3 on transferrin receptor (TfR) vesicles and syntaxin 4 at the basolateral membrane of brain microvascular endothelial cells mediates the final fusion step of TfR transcytosis.
Endothelial Cells Expressing CPE and vWF Are Involved in the Immunopathogenesis of Primary Biliary Cholangitis
[Scientific Reports] scRNA-seq data were initially analyzed using R statistical software and Cell Ranger. Differentially expressed genes and marker genes were identified using Seurat.
Loss of Endothelial ZEB2 in Mice Attenuates Steatosis Early during Metabolic Dysfunction-Associated Steatotic Liver Disease
[Scientific Reports] To investigate a potential protective role against steatosis, the initial metabolic dysfunction-associated steatotic liver disease stage, researchers fed endothelial cell-specific Zeb2 knockout mice a western-type diet.
AGGF1-Primed Endothelial Progenitor Cells Alleviate Ischaemia-Reperfusion Injury in Diabetic Hearts
[Scientific Reports] The authors observed that the damaging effects of hyperglycemia + hypoxia/reoxygenation on endothelial progenitor cells were abolished by angioGenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1).
Remdesivir Inhibits Endothelial Activation and Atherosclerosis by Coupling TAL1 to TRAF6
[Journal of Translational Medicine] Pharmacological treatment with remdesivir significantly reduced atherosclerotic lesions in the total aorta and decreased VCAM-1 expression in aortic roots of ApoE−/− mice.
Nanosilicates Promote Angiogenesis through Activation of ROS-Mediated WNT/β-catenin Pathway
[Science Advances] Researchers introduced nanosilicates as proangiogenic biomaterials that can prime endogenous cells to expedite angiogenesis and graft vascularization in vivo.
Sphingosine-1-Phosphate (S1P) in Whole Liver Recellularization Improves Endothelization of Acellular Liver Scaffold
[ACS Biomaterials Science & Engineering] Researchers presented a novel approach to enhance the re-endothelialization of decellularized rat liver scaffolds by seeding HUVECs in the presence of S1P, aiming to bioengineer a fully endothelialized liver.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
