The hepatocellular carcinoma ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages.
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Sharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., Erdal, S., Teo, H. M., Khalilnezhad, A., Chakarov, S., Lim, T. K. H., Fui, A. C. Y., Chieh, A. K. W., Chung, C. P., Bonney, G. K., … DasGupta, R. (2020). Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.08.040 Cite
Scientists utilized single-cell transcriptomics to systematically map the cell-type-specific gene expression in a chemotherapy-resistant osteosarcoma tumor.
[Signal Transduction and Targeted Therapy]
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Wang, L., Huang, X., You, X., Yi, T., Lu, B., Liu, J., Lu, G., Ma, M., Zou, C., Wu, J., & Zhao, W. (2020). Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00248-x Cite
The authors present an objective review of the key senescence-related alterations of the major intracellular organelles and analyze the role of relevant cell types for senescence and atherogenesis.
Endothelial calmodulin (CaM), a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for leukocyte transendothelial migration.
[Journal of Experimental Medicine]
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Dalal, P. J., Sullivan, D. P., Weber, E. W., Sacks, D. B., Gunzer, M., Grumbach, I. M., Heller Brown, J., & Muller, W. A. (2021). Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration. Journal of Experimental Medicine, 218(1). https://doi.org/10.1084/jem.20192378 Cite
Inspired by the human placenta scientists established a coculture of a trophoblast-derived cell line, together with primary placental fibroblasts within the biological membrane and primary human placental endothelial cells—representing three cellular components of the human placental villus.
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Kreuder, A.-E., Bolaños-Rosales, A., Palmer, C., Thomas, A., Geiger, M.-A., Lam, T., Amler, A.-K., Markert, U. R., Lauster, R., & Kloke, L. (2020). Inspired by the human placenta: a novel 3D bioprinted membrane system to create barrier models. Scientific Reports, 10(1), 15606. https://doi.org/10.1038/s41598-020-72559-6 Cite
While respiratory symptoms are the major clinical manifestations, cardiovascular abnormalities, including arrhythmias, myocarditis, heart failure, and ischemic stroke, have been reported in a significant number of COVID-19 patients.
[Acta Pharmacologica Sinica]
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Adenoviral vectors carrying genes encoding vascular endothelial growth factor, glial cell-derived neurotrophic factor and neural cell adhesion molecule or gene engineered umbilical cord blood mononuclear cells overexpressing recombinant vascular endothelial growth factor, glial cell-derived neurotrophic factor, and neural cell adhesion molecule were intrathecally injected before distal occlusion of the middle cerebral artery in rats.
[International Journal of Molecular Sciences]
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Markosyan, V., Safiullov, Z., Izmailov, A., Fadeev, F., Sokolov, M., Kuznetsov, M., Trofimov, D., Kim, E., Kundakchyan, G., Gibadullin, A., Salafutdinov, I., Nurullin, L., Bashirov, F., & Islamov, R. (2020). Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat. International Journal of Molecular Sciences, 21(18), 6858. https://doi.org/10.3390/ijms21186858 Cite
Researchers found that NanoNOS greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting NanoNOS treatment could help prevent cardiovascular diseases.
The authors provide a comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms.
[Cell Death & Disease]
Roche announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of Tecentriq® in combination with Avastin® for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have not received prior systemic therapy.
[F. Hoffmann-La Roche Ltd]
Aerpio Pharmaceuticals, Inc. announced that it has completed patient enrollment in its double-blind, placebo-controlled Phase II trial in patients with elevated intraocular pressure associated with open angle glaucoma or ocular hypertension.
[Aerpio Pharmaceuticals, Inc.]