Towards Maturation of Human Otic Hair Cell-Like Cells in Pluripotent Stem Cell–Derived Organoid Transplants

Investigators devised a strategy to enhance maturation of otic progenitor cells toward human hair cell–like cells by assembling 3D otic organoids that contain human pluripotent stem cell-derived otic cells, endothelial cells, and mesenchymal stem cells.
[Cell and Tissue Research]
Moeinvaziri, F., Shojaei, A., Haghparast, N., Yakhkeshi, S., Nemati, S., Hassani, S.-N., & Baharvand, H. (2021). Towards maturation of human otic hair cell–like cells in pluripotent stem cell–derived organoid transplants. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03510-y Cite
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MK2206 Attenuates Atherosclerosis by Inhibiting Lipid Accumulation, Cell Migration, Proliferation, and Inflammation

Scientists revealed that MK2206 suppressed migration, proliferation, and inflammation in vascular smooth muscle cells. Moreover, MK2206 inhibited proliferation and inflammation of endothelial cells.
[Acta Pharmacologica Sinica]
Tang, Y., Li, Z., Feng, Y., Yang, H., Hou, C., Geng, C., Yang, P., Zhao, H., & Wang, J. (2021). MK2206 attenuates atherosclerosis by inhibiting lipid accumulation, cell migration, proliferation, and inflammation. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-021-00729-x Cite
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Corneal Lymphangiogenesis in Dry Eye Disease Is Regulated by Substance P/Neurokinin-1 Receptor System through Controlling Expression of Vascular Endothelial Growth Factor Receptor 3

Immunocytochemistry, angiogenesis assay, and western blot analysis of human dermal lymphatic endothelial cells were conducted to assess the involvement of substance P/neurokinin-1 receptor system in lymphangiogenesis.
[Ocular Surface]
Corneal lymphangiogenesis in dry eye disease is regulated by substance P/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3 - ScienceDirect. (n.d.). Retrieved July 27, 2021, from https://www.sciencedirect.com/science/article/pii/S1542012421000756 Cite
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Lactate Consumption via Cascaded Enzymes Combined VEGF siRNA for Synergistic Anti-Proliferation and Anti-Angiogenesis Therapy of Tumors

A codelivery strategy that combined the cascaded enzymes lactate oxidase/catalase and vascular endothelial growth factor siRNA to suppress tumor proliferation and angiogenesis synergistically was proposed.
[Advanced Healthcare Materials]
Tang, Y., Jia, C., Wang, Y., Wan, W., Li, H., Huang, G., & Zhang, X. (n.d.). Lactate Consumption via Cascaded Enzymes Combined VEGF siRNA for Synergistic Anti-Proliferation and Anti-Angiogenesis Therapy of Tumors. Advanced Healthcare Materials, n/a(n/a), 2100799. https://doi.org/10.1002/adhm.202100799 Cite
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Exosomes in Atherosclerosis, a Double-Edged Sword: Their Role in Disease Pathogenesis and Their Potential as Novel Therapeutics

Scientists summarize the current understanding of exosome biogenesis and uptake, and discuss atherogenic and atheroprotective functions of exosomes secreted from these cell types.
[AAPS Journal]
Patel, N., Chin, D. D., & Chung, E. J. (2021). Exosomes in Atherosclerosis, a Double-Edged Sword: Their Role in Disease Pathogenesis and Their Potential as Novel Therapeutics. The AAPS Journal, 23(5), 95. https://doi.org/10.1208/s12248-021-00621-w Cite
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Blood Vessel Organoids Research from Penninger Lab to Play Central Role in 100 Years of Insulin UK-Canada Team Grant Research

LSI Director Dr. Josef Penninger and Drs. David Long, Luigi Gnudi, and Karen Price in the UK are recipients of a UK-Canada Diabetes Research Team Grant entitled “Bridging the gap to translation by understanding and preventing diabetic vascular complications using human organoid culture” as part of the 100 Years of Insulin initiative.
[The University of British Columbia]
Press Release
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Hofbauer Cells and Coronavirus Disease 2019 (COVID-19) in Pregnancy: Molecular Pathology Analysis of Villous Macrophages, Endothelial Cells, and Placental Findings from 22 Placentas Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) with and without Fetal Transmission

SARS-CoV-2 could extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas.
[Archives of Pathology & Laboratory Medicine]
Schwartz, D. A., Baldewijns, M., Benachi, A., Bugatti, M., Bulfamante, G., Cheng, K., Collins, R. R. J., Debelenko, L., De Luca, D., Facchetti, F., Fitzgerald, B., Levitan, D., Linn, R. L., Marcelis, L., Morotti, D., Morotti, R., Patanè, L., Prevot, S., Pulinx, B., … Zaigham, M. (2021). Hofbauer cells and coronavirus disease 2019 (COVID-19) in pregnancy: Molecular pathology analysis of villous macrophages, endothelial cells, and placental findings from 22 placentas infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without fetal transmission. Archives of Pathology & Laboratory Medicine. https://doi.org/10.5858/arpa.2021-0296-SA Cite
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HO-1 Nuclear Accumulation and Interaction with NPM1 Protect against Stress-Induced Endothelial Senescence Independent of Its Enzymatic Activity

Scientists showed that heme oxygenase-1 (HO-1) was accumulated in the nuclei of stress-induced senescent endothelial cells, and conferred protection against endothelial senescence independent of its enzymatic activity.
[Cell Death & Disease]
Luo, W., Li, J., Li, Z., Lin, T., Zhang, L., Yang, W., Mai, Y., Liu, R., Chen, M., Dai, C., Yang, H., Lu, J., Li, H., Guan, G., Huang, M., Liu, P., & Li, Z. (2021). HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity. Cell Death & Disease, 12(8), 1–13. https://doi.org/10.1038/s41419-021-04035-6 Cite
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Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus

Primary podocytes were isolated and subjected to analysis of Wnt signaling and fatty acid metabolism. Conditioned media from primary podocytes was transferred to glomerular endothelial cells.
[Journal of the American Heart Association]
Srivastava, S. P., Zhou, H., Setia, O., Dardik, A., Fernandez‐Hernando, C., & Goodwin, J. (n.d.). Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus. Journal of the American Heart Association, 0(0), e019437. https://doi.org/10.1161/JAHA.120.019437 Cite
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Characterization of Circulating Extracellular Vesicle Surface Antigens in Patients with Primary Aldosteronism

Nineteen extracellular vesicle surface antigens were differentially expressed in patients with primary aldosteronism compared with patients with essential hypertension or normotensive controls, including markers of activated platelets, endothelial and immune/inflammatory cells.
[Hypertension]
Burrello, J., Tetti, M., Forestiero, V., Biemmi, V., Bolis, S., Pomatto, M. A. C., Amongero, M., Di Silvestre, D., Mauri, P., Vassalli, G., Camussi, G., Williams, T. A., Mulatero, P., Barile, L., & Monticone, S. (n.d.). Characterization of Circulating Extracellular Vesicle Surface Antigens in Patients With Primary Aldosteronism. Hypertension, 0(0), HYPERTENSIONAHA.121.17136. https://doi.org/10.1161/HYPERTENSIONAHA.121.17136 Cite
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Whole Exome Sequencing Identified FAM149A as a Plausible Causative Gene for Congenital Hereditary Endothelial Dystrophy, Affecting Nrf2-Antioxidant Signaling upon Oxidative Stress

FAM149A was found to be highly expressed in corneal endothelium, and up-regulated upon oxidative stress.
[Free Radical Biology and Medicine]
Zhang, J., Dai, Y., Wu, D., Li, Y., & Xu, J. (2021). Whole exome sequencing identified FAM149A as a plausible causative gene for congenital hereditary endothelial dystrophy, affecting Nrf2-Antioxidant signaling upon oxidative stress. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2021.07.029 Cite
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