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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
CD8 T Cells As Drivers of Blood-Brain Barrier Disruption
[Trends In Neurosciences] Investigators discuss the mechanisms of CD8 T cell-mediated blood-brain barrier (BBB) disruption, including the roles of antigen presentation through MHC class I molecules, which emerge as an important determining feature of BBB disruption and immune cell infiltration into the brain.
Pioneer Factor ETV2 Safeguards Endothelial Cell Specification by Recruiting the Repressor REST to Restrict Alternative Lineage Commitment
[Nature Cardiovascular Research] Investigators studied mechanisms by which ETV2 overexpression in hiPSC-derived mesodermal progenitors efficiently specifies endothelial cells.
$60M Donation Will Fund Cardiovascular Institute at Vancouver General Hospital
[CBC] The head cardiologist at Vancouver General Hospital says a $60 million donation toward a new cardiovascular health institute and innovation fund will have a life-saving impact around the world.
The Distinct Transcriptomic Signature of the Resolution Phase Fibroblast-Like Synoviocytes Supports Endothelial Cell Dysfunction
[Communications Biology] Scientists performed histopathological evaluations of the joints from an inducible tumor necrosis factor-alpha transgenic mouse model to reveal that phenotypic rheumatoid arthritis hallmarks were all reversed upon the initiation of resolution.
Misdirected Yet Intact TREX1 Exonuclease Activity Causes Human Cerebral and Systemic Small Vessel Disease
[Brain] Researchers evaluated TREX1 sequencing data from 469 229 UK Biobank participants together with retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations-related microvascular clinical and imaging outcomes.
Sprayable Reactive Oxygen Species-Responsive Hydrogel Coatings Restore Endothelial Barrier Integrity for Functional Vascular Healing
[ACS nano] The authors identified the elimination of excess reactive oxygen species as a key mechanism for reinforcing intercellular tight junctions and restoring the endothelial barrier function.
Unravelling Soluble (Pro)Renin Receptor-Mediated Endothelial Dysfunction
[European journal of pharmacology] Human uterine microvascular endothelial cells were treated with 100 nM soluble prorenin receptor, with/without 10 nM PRO20, 10 μM Losartan, or 10 μM Aliskerin.
Regulation of Blood-Brain Barrier Integrity by Brain Microvascular Endothelial Cells in Ischemic Stroke: A Therapeutic Opportunity.
[European journal of pharmacology] Scientists systematically discuss the central role of brain microvascular endothelial cells (BMECs) in ischemia. The mitochondrial dysfunction and activation of apoptosis/necrosis pathways in BMECs directly disrupt the integrity of the BBB and the degradation of junctional complexes further exacerbates its permeability.
Ischemic Endothelial Necroptosis Induces Haemolysis and COVID-19 Angiopathy
[Nature] The authors demonstrated extensive endothelial cell (EC) death in the microvasculature of COVID-19 organs. Notably, EC death was not associated with fibrin formation or platelet deposition, but was linked to microvascular red blood cell hemolysis.
Association of Endothelial Dysfunction with Chronic Marijuana Smoking and THC-Edible Use
[JAMA Cardiology] Investigators studied whether cannabis use is associated with vascular endothelial dysfunction.
Endothelial TREM-1 Mediates Sepsis-Induced Blood‒Brain Barrier Disruption and Cognitive Impairment via the PI3K/Akt Pathway
[Journal of Neuroinflammation] Investigators established a hiPSC-derived blood‒brain barrier (BBB) model and reported that treating with sepsis patient serum leads to structural and functional disruption of the BBB.
The Impact of VEGF-C-Induced Dural Lymphatic Vessel Growth on Ischemic Stroke Pathology
[Translational Stroke Research] Researchers injected mice with a single intracerebroventricular dose of adeno-associated viral particles encoding vascular endothelial growth factor C (VEGF-C) before subjecting them to transient middle cerebral artery occlusion.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
