Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

RNA Binding Protein HUD Mediates the Crosstalk between β Cells and Islet Endothelial Cells by the Regulation of Endostatin and Serpin E1 Expression

[Cell Death & Disease] Co-cultures of βTC6 cells and pancreatic islet endothelial MS1 cells were used to assess the crosstalk between β cells and islet endothelial cells, and the results showed that HuD downregulation in βTC6 cells inhibited the growth and migration of MS1 cells.

Monitoring of Cell-Cell Communication and Contact History in Mammals

[Science] To understand the dynamic in vivo cell-cell communications over time, scientists developed an intercellular genetic approach using the synthetic Notch pathway that converted a cellular contact event into a controllable transcriptional program.

Cancer Immunotherapies Transition Endothelial Cells into HEVs That Generate TCF1+ T Lymphocyte Niches through a Feed-Forward Loop

[Cancer Cell] By employing single-cell transcriptomics, endothelial fate mapping, and functional multiplex immune profiling, researchers demonstrated that antiangiogenic immune-modulating therapies evoke transdifferentiation of postcapillary venules into inflamed high-endothelial venules (HEVs).

Mouse Placenta Fetal Macrophages Arise from Endothelial Cells outside the Placenta

[Developmental Cell] Using a new Hoxa13Cre allele that labeled all placental endothelial cells, investigators demonstrated that mouse placental fetal macrophages did not arise from placental endothelium.

Integration of Single-Cell Transcriptomes and Biological Function Reveals Distinct Behavioral Patterns in Bone Marrow Endothelium

[Nature Communications] Scientists used the Tie2-CreERT2;Rosa26-tdTomato reporter mouse to trace, profile, and cultivate primary endothelial cells (ECs) from different organs and to study bone marrow endothelial cells.

An NKX-COUP-TFII Morphogenetic Code Directs Mucosal Endothelial Addressin Expression

[Nature Communications] The authors identified conserved NKX-COUP-TFII composite elements in regulatory regions of Madcam1 and St6gal1 that bind intestinal homeodomain protein NKX2-3 cooperatively with venous nuclear receptor COUP-TFII to activate transcription.

Endothelial Rbpj Deletion Normalizes Notch4-Induced Brain Arteriovenous Malformation in Mice

[Journal of Experimental Medicine] To test whether targeting downstream signaling, while sustaining the causal Notch4*tetEC expression, induced arteriovenous malformation normalization, investigators deleted Rbpj by combining Notch4*tetEC with tamoxifen-inducible Rbpj deletion.

Activation of Wnt/β-Catenin Signaling by Zeb1 in Endothelial Progenitors Induces Vascular Quiescence Entry

[Cell Reports] Researchers uncovered a role of Zeb1 in defining vascular quiescence entry. During quiescence acquisition, Zeb1 increased along with the progressive decline of endothelial progenitors’ activities, with Zeb1 loss resulting in endothelial overgrowth and vascular deformities.

Fibroblasts Repair Blood-Brain Barrier Damage and Hemorrhagic Brain Injury via TIMP2

[Cell Reports] By targeting Col1α1, scientists generated mice with ablated Col1α1+ fibroblasts. These mutants showed exacerbated blood-brain barrier damage, enlarged injury volume, and worse neurological function, highlighting a beneficial role of Col1α1+ fibroblasts in intracerebral hemorrhage.

Angiotensin-(1–9) Prevents Angiotensin II-Induced Endothelial Apoptosis through CNPY2/PERK Pathway

[Apoptosis] Investigators elucidated the effects of Angiotensin-(1–9) on endothelial apoptosis and the underlying molecular mechanism in angiotensin II induced hypertension.

Organotypic Stromal Cells Impact Endothelial Cell Transcriptome in 3D Microvessel Networks

[Scientific Reports] Researchers generated 3D microvessel networks by combining a common naïve endothelial cell with six different stromal cells derived from the lung, skin, heart, bone marrow, pancreas, and pancreatic cancer.

Endothelial Cell-Specific Mineralocorticoid Receptor Activation Promotes Diastolic Dysfunction in Diet-Induced Obese Male Mice

[American Journal of Physiology-Regulatory, Integrative and Comparative Physiology] To determine the specific role of mineralocorticoid receptor in endothelial cells (ECMR) activation in the pathogenesis of diastolic dysfunction, scientists fed four-week-old ECMR knockout male mice and littermates with either a Western diet or chow diet for 16 weeks.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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