Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

HYPOXIA Induces lncRNA HOTAIR for Recruiting RELA in Papillary Thyroid Cancer Cells to Upregulate miR-181a and Promote Angiogenesis

[Journal Of Endocrinological Investigation] Scientists examined the regulatory mechanism of miR-181a under conditions of hypoxia and its impact on angiogenesis. The regulatory effect of GATA6 on angiogenesis was studied using CCK8, EdU, Transwell, and western blot assays.

The Mechanosensory Channel PIEZO1 Functions Upstream of Angiopoietin/TIE/FOXO1 Signaling in Lymphatic Development

[Journal Of Clinical Investigation] Investigators identified crosstalk between piezo-type mechanosensitive ion channel component 1 (PIEZO1), angiopoietin 2 (ANGPT2), and tyrosine kinase with Ig-like and EGF-like domains 1 (TIE1) and showed that activation of the mechanosensory channel PIEZO1 in lymphatic endothelial cells caused rapid exocytosis of the TIE ligand ANGPT2 and more.

Novel Angiogenesis Inhibitors with Superoxide Anion Radical Amplification Effect: Surmounting the Achilles’ Heels of Angiogenesis Inhibitors and Photosensitizers

[European Journal Of Medicinal Chemistry] 11 novel angiogenesis inhibitors were developed through hybridization strategy to overcome their clinical limitations. These title compounds boast excitation wavelengths within the “therapeutic window”, enabling deep tissue penetration.

CCL4 Contributes to Aging Related Angiogenic Insufficiency through Activating Oxidative Stress and Endothelial Inflammation

[Angiogenesis] Scientists hypothesized that chemokine C-C motif ligands 4 (CCL4) might play a vital role in aging-related vascular dysfunction. Circulating CCL4 was up-regulated in elderly subjects and in aged animals.

Engineered Nanomicelles Targeting Proliferation and Angiogenesis Inhibit Tumour Progression by Impairing the Synthesis of Ceramide-1-Phosphate

[Nanoscale] Researchers engineered sub-100 sized nanomicelles targeting proliferation and angiogenesis using an esterase-sensitive phosphocholine-tethered docetaxel conjugate of lithocholic acid (LCA) and a poly(ethylene glycol) derivative of an LCA–combretastatin A4 conjugate.

Estrogen Stimulates Fetal Vascular Endothelial Growth Factor Expression and Microvascularization

[Journal Of Endocrinology] Investigators showed that estrogen upregulates skeletal muscle VEGF expression and systemic microvessel development within the fetus as an essential programming event critical for ontogenesis of systemic vascular function and insulin sensitivity/glucose homeostasis after birth in primate offspring.

New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases

[Journal Of Histochemistry & Cytochemistry] During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) produce lactate and ATP by aerobic glycolysis. Local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation.

Firms Offering a Fast Track to Publication Target Foreign Applicants to US Medical Residency Programs

[Science Insider] Based in Atlanta, Desai runs a business that offers junior doctors from around the world a chance to beef up their CVs before applying for coveted residency or fellowship positions at hospitals or physician offices in the United States.

Multi-Omics Analysis of Human Tendon Adhesion Reveals That ACKR1-Regulated Macrophage Migration Is Involved in Regeneration

[Bone Research] Scientists found that SPP1+ macrophages, RGCC+ endothelial cells, ACKR1+ endothelial cells and ADAM12+ fibroblasts participated in tendon adhesion formation.

Aging-Regulated PNUTS Maintains Endothelial Barrier Function via SEMA3B Suppression

[Communications Biology] Investigators determined the role of Phosphatase 1 Nuclear Targeting Subunit (PNUTS) in endothelial cell aging. They confirmed that PNUTS was repressed in senescent endothelial cells.

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings from a Randomized Controlled Study

[Journal Of The American Heart Association] The authors examined the acute effects of provoked anger, and secondarily, anxiety and sadness on endothelial cell health.

New $2 Million Research Initiative Will Study Heart and Brain Health in People With Autism

[American Heart Association] According to the US Centers for Disease Control and Prevention, 1 in 36 children and 1 in 45 adults in the US have autism, a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.