Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

The Crosstalk between Endothelial Cells and Vascular Smooth Muscle Cells Aggravates High Phosphorus-Induced Arterial Calcification

[Cell Death & Disease] Scientists investigated the role of exosomes derived from endothelial cells in arterial calcification and its potential mechanisms in end-stage renal disease.

Targeting HECTD3-IKKα Axis Inhibits Inflammation-Related Metastasis

[Signal Transduction and Targeted Therapy] Scientists showed that HECTD3 deficiency in vascular endothelial cells significantly reduced tumor metastasis in multiple mouse models.

LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction

[Circulation Research] Investigators found that mice had elevated LPA level in peripheral blood, as well as increased cardiac expression of its receptor LPA2 in the early stages after myocardial infarction.

Angiopoietin-2 Inhibition Attenuates Kidney Fibrosis by Hindering Chemokine C-C Motif Ligand 2 Expression and Apoptosis of Endothelial Cells.

[Kidney International] Researchers found in a cohort of 319 patients with chronic kidney disease that plasma angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratios were positively associated with the development of kidney failure.

UV-B Filter Octylmethoxycinnamate-Induced Vascular Endothelial Disruption on Rat Aorta: In Silico and In Vitro Approach

[Chemosphere] The authors analyzed the effects of octylmethoxycinnamate on rat aorta vasculature and explored the modes of action implicated in these effects.

Understanding COVID-19-Associated Coagulopathy

[Nature Reviews Immunology] Investigators categorize the current understanding of COVID-19-associated coagulopathy into three main pathological mechanisms: first, vascular endothelial cell dysfunction; second, a hyper-inflammatory immune response; and last, hypercoagulability.

Activating Transcription Factor 6 Protects against Endothelial Barrier Dysfunction

[Cellular Signalling] The in vitro effects of AA147 and Ceapin-A7 in lipopolysaccharides-induced endothelial barrier dysfunction were investigated in bovine pulmonary artery endothelial cells.

Gab2-MALT1 Axis Regulates Thromboinflammation and Deep Vein Thrombosis

[Blood] The authors showed that Gab2 facilitated the assembly of the CARD-BCL10-MALT1 signalosome, which mediated the activation of Rho and NF-kB in endothelial cells.

Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis

[Circulation Research] Researchers investigated the mechanoregulation of UCP2 (uncoupling protein 2) expression in endothelial cells and the effect of UCP2 on endothelial inflammation and atherogenesis.

SOX9 Reprograms Endothelial Cells by Altering the Chromatin Landscape

[Nucleic Acids Research] Using human umbilical vein endothelial cells (HUVECs), researchers showed that SOX9 expression alone was sufficient to activate mesenchymal genes and steer endothelial cells towards a mesenchymal fate.

Neuropeptide Y, a Paracrine Factor Secreted by Cancer Cells, Is an Independent Regulator of Angiogenesis in Colon Cancer

[British Journal of Cancer] Orthotopic HT29 with intact vascular endothelial growth factor-A (VEGF-A) gene and VEGF-A knockdown HT29 colon cancer-bearing mice were treated with specific Y2 receptor antagonists, and the effects on angiogenesis and tumour growth were studied.

WNK1 Collaborates with TGF-β in Endothelial Cell Junction Turnover and Angiogenesis

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that inhibition of WNK1 promoted TGF-β–dependent degradation of the tyrosine kinase receptor AXL, which was involved in TGF-β–mediated cell migration and angiogenesis.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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