Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Lymphatic Vessels in Bone Support Regeneration after Injury

[Cell] The authors found that lymphatic vessels in bone expand during genotoxic stress. VEGF-C/VEGFR-3 signaling and genotoxic stress-induced IL6 drive lymphangiogenesis in bones.

HUTCHMED Announces License to Takeda to Develop and Commercialize Fruquintinib outside China

[HUTCHMED (China) Limited] HUTCHMED (China) Limited announced that its subsidiary, HUTCHMED Limited, has entered into an exclusive license agreement with a subsidiary of Takeda Pharmaceutical Company Limited to further the global development, commercialization and manufacture of fruquintinib outside of mainland China, Hong Kong and Macau.

DNA/DMXAA/Metal-Organic Framework Activator of Innate Immunity for Boosting Anticancer Immunity

[Advanced Materials] Investigators reported that metal-organic framework-801 could be employed as stimulator of interferon genes through Toll-like receptor 4 and not just as a drug delivery carrier.

Endoderm-Derived islet1-Expressing Cells Differentiate into Endothelial Cells to Function as the Vascular HSPC Niche in Zebrafish

[Developmental Cell] Scientists found that islet1 (isl1)-expressing cells were the progenitors of the venous endothelial cells that constituted the majority of the hematopoietic stem and progenitor cells (HSPCs) niche.

Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization

[Cancer Research] Using ultrastructural and functional imaging, researchers demonstrated that dynamic changes of activated brain microcapillaries promoted the mandatory first steps of brain colonization.

Co-Culture Models of Endothelial Cells, Macrophages, and Vascular Smooth Muscle Cells for the Study of the Natural History of Atherosclerosis

[Plos One] Scientists presented a fast, affordable, and reproducible three-cell co-culture system that could represent the different cellular mechanisms of atherosclerosis, extending from atherogenesis to pathological intimal thickening.

Endothelial Glycocalyx and Cardiomyocyte Damage Is Prevented by Recombinant Syndecan-1 in Acute Myocardial Infarction

[The American Journal of Pathology] The authors investigated the effects of acute myocardial infarction on endothelial nanomechanics and function and the use of exogenous recombinant syndecan-1, a major component of the endothelial glycocalyx, as recovering agent.

The Systemic and Hepatic Alternative Renin–Angiotensin System Is Activated in Liver Cirrhosis, Linked to Endothelial Dysfunction and Inflammation

[Scientific Reports] Researchers assessed the systemic and hepatic renin-angiotensin-system fingerprint in advanced chronic liver disease.

Estrogen Receptor Alpha Mediates 17β-Estradiol, Up-Regulates Autophagy, and Alleviates Hydrogen Peroxide-Induced Vascular Senescence

[Biogerontology] Investigators determined the role of estrogen receptor α and β in the effects of 17β-estradiol on vascular autophagy and aging through in vitro and in vivo models.

Loss of Fatty Acid Binding Protein 3 Ameliorates Lipopolysaccharide-Induced Inflammation and Endothelial Dysfunction

[Journal of Biological Chemistry] Scientists evaluated the pathophysiological role of endothelial fatty acid binding protein 3 and related mechanisms in vitro.

N6-Methylation of RNA-Bound Adenosine Regulator HNRNPC Promotes Vascular Endothelial Dysfunction in Type 2 Diabetes Mellitus by Activating the PSEN1-Mediated Notch Pathway

[Diabetes Research and Clinical Practice] Analysis of candidate m6A methylation regulators was conducted in the thoracic aorta of db/db mice and high glucose-induced human umbilical vein endothelial cells

Replicating Endothelial Shear Stress in Organ-on-A-Chip for Predictive Hypericin Photodynamic Efficiency

[International Journal of Pharmaceutics] Researchers developed a microchip that generated a constant shear stress force to investigate the efficiency of photodynamic therapy using hypericin on human umbilical vein endothelial cells.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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