Isolation and Characterisation of Lymphatic Endothelial Cells from Lung Tissues Affected by Lymphangioleiomyomatosis

Hhuman primary-cultured lymphatic endothelial cells were obtained both from lymphangioleiomyomatosis-affected lung tissues and normal lung tissues using fluorescence-activated cell sorting.
[Scientific Reports]
Nishino, K., Yoshimatsu, Y., Muramatsu, T., Sekimoto, Y., Mitani, K., Kobayashi, E., Okamoto, S., Ebana, H., Okada, Y., Kurihara, M., Suzuki, K., Inazawa, J., Takahashi, K., Watabe, T., & Seyama, K. (2021). Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis. Scientific Reports, 11(1), 8406. https://doi.org/10.1038/s41598-021-88064-3 Cite
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Serotonin-Induced Vascular Permeability Is Mediated by Transient Receptor Potential Vanilloid 4 in the Airways and Upper Gastrointestinal Tract of Mice

The authors investigated the role of Transient Receptor Potential Vanilloid 4 in 5-HT-induced plasma extravasation using pharmacological and genetic approaches.
[Laboratory Investigation]
Retamal, J. S., Grace, M. S., Dill, L. K., Ramirez-Garcia, P., Peng, S., Gondin, A. B., Bennetts, F., Alvi, S., Rajasekhar, P., Almazi, J. G., Carbone, S. E., Bunnett, N. W., Davis, T. P., Veldhuis, N. A., Poole, D. P., & McIntyre, P. (2021). Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice. Laboratory Investigation, 1–14. https://doi.org/10.1038/s41374-021-00593-7 Cite
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Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset

Investigators report that patients with sporadic myotrophic lateral sclerosis (ALS) present cell activity patterns consistent with two mouse models in which enrichments of vascular cell genes preceded microglial response.
[Nature Medicine]
Månberg, A., Skene, N., Sanders, F., Trusohamn, M., Remnestål, J., Szczepińska, A., Aksoylu, I. S., Lönnerberg, P., Ebarasi, L., Wouters, S., Lehmann, M., Olofsson, J., von Gohren Antequera, I., Domaniku, A., De Schaepdryver, M., De Vocht, J., Poesen, K., Uhlén, M., Anink, J., … Lewandowski, S. A. (2021). Altered perivascular fibroblast activity precedes ALS disease onset. Nature Medicine, 27(4), 640–646. https://doi.org/10.1038/s41591-021-01295-9 Cite
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TRIM27 Contributes to Glomerular Endothelial Cell Injury in Lupus Nephritis by Mediating the FoxO1 Signaling Pathway

Researchers detected the expression of the tripartite motif-containing 27 (TRIM27) protein in glomerular endothelial cells in vivo and in vitro.
[Laboratory Investigation]
Liu, J., Xu, J., Huang, J., Gu, C., Liu, Q., Zhang, W., Gao, F., Tian, Y., Miao, X., Zhu, Z., Jia, B., Tian, Y., Wu, L., Zhao, H., Feng, X., & Liu, S. (2021). TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway. Laboratory Investigation, 1–15. https://doi.org/10.1038/s41374-021-00591-9 Cite
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The Glycolytic Process in Endothelial Cells and Its Implications

Since the switches among metabolic processes precede the functional changes and disease developments, some prophylactic and/or therapeutic strategies concerning the role of glycolysis in cardiovascular disease are discussed.
[Acta Pharmacologica Sinica]
Susan, W. S. L., & Shi, Y. (2021). The glycolytic process in endothelial cells and its implications. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-021-00647-y Cite
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Ferritinophagy Is Involved in the Zinc Oxide Nanoparticles-Induced Ferroptosis of Vascular Endothelial Cells

Scientists report that zinc oxide nanoparticles can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner.
[Autophagy]
Qin, X., Zhang, J., Wang, B., Xu, G., Yang, X., Zou, Z., & Yu, C. (2021). Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells. Autophagy, 0(0), 1–20. https://doi.org/10.1080/15548627.2021.1911016 Cite
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Endothelial SIRT3 Regulates Myofibroblast Metabolic Shifts in Diabetic Kidneys

Researchers found that endothelial SIRT3 regulated metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice.
[iScience]
Srivastava, S. P., Li, J., Takagaki, Y., Kitada, M., Goodwin, J., Kanasaki, K., & Koya, D. (2021). Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102390 Cite
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Defining the Lineage of Thermogenic Perivascular Adipose Tissue

The cellular origins of perivascular adipose tissue are poorly understood. Investigators determined the identity of perivascular adipocyte progenitors in mice and humans
[Nature Metabolism]
Angueira, A. R., Sakers, A. P., Holman, C. D., Cheng, L., Arbocco, M. N., Shamsi, F., Lynes, M. D., Shrestha, R., Okada, C., Batmanov, K., Susztak, K., Tseng, Y.-H., Liaw, L., & Seale, P. (2021). Defining the lineage of thermogenic perivascular adipose tissue. Nature Metabolism, 1–16. https://doi.org/10.1038/s42255-021-00380-0 Cite
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Angiogenesis-Related Non-Coding RNAs and Gastrointestinal Cancer

Scientists discuss the role of ncRNAs in mediating angiogenesis in various types of gastrointestinal cancers and look forward to the introduction of mimetics and antagonists as possible therapeutic agents.
[Molecular Therapy-Oncolytics]
Razavi, Z. S., Asgarpour, K., Mahjoubin-Tehran, M., Rasouli, S., Khan, H., Shahrzad, M. K., Hamblin, M. R., & Mirzaei, H. (2021). Angiogenesis-related non-coding RNAs and gastrointestinal cancer. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.04.002 Cite
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Endothelial Struts Enable the Generation of Large Lumenized Blood Vessels De Novo

Researchers describe a model for large vessel formation that does not require a cord-like structure or a hollowing step.
[Nature Cell Biology]
Weijts, B., Shaked, I., Ginsberg, M., Kleinfeld, D., Robin, C., & Traver, D. (2021). Endothelial struts enable the generation of large lumenized blood vessels de novo. Nature Cell Biology, 23(4), 322–329. https://doi.org/10.1038/s41556-021-00664-3 Cite
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Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation

The authors cover the current understanding of the role of oxidative stress (OS) in the endothelial adaptive or maladaptive multifaceted response to sepsis and to outline the therapeutic potential and issues of targeting OS and endothelial dysfunction during sepsis and septic shock.
[Antioxidants & Redox Signaling]
Joffre, J., & Hellman, J. (2021). Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2021.0027 Cite
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