Clovis Oncology, Inc. announcedtreatment of the first patient in the Phase II portion of the LIO-1 trial evaluating the combination of lucitanib, Clovis’ investigational angiogenesis inhibitor, including VEGFR1-3, and Opdivo®, Bristol Myers Squibb’s PD-1 inhibitor, for the treatment of gynecologic cancers.
[Clovis Oncology, Inc.]
Aerpio Pharmaceuticals, Inc. and the US Government operating through the Medical Technology Enterprise Consortium announced that an agreement has been reached to evaluate razuprotafib in a new randomized, investigational trial for the prevention and treatment of Acute Respiratory Distress Syndrome (ARDS) in adult patients with moderate to severe COVID-19.
[Aerpio Pharmaceuticals, Inc. ]
Continue reading “Aerpio Pharmaceuticals, Inc. Announces a Second Clinical Trial with Funding from MTEC to Evaluate Razuprotafib for the Prevention and Treatment of ARDS in Patients with Moderate to Severe COVID-19”
Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
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Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-z Cite
The author investigated the microscopic architecture of endothelial cells in human atherosclerosis and to determine whether the potential structural abnormalities of endoplasmic reticulum and mitochondria may play a central pathogenic role in atherogenesis or may merely reflect the condition of a tissue whose integrity has already been disturbed or destroyed.
[Journal of Anatomy]
Scientists showed that deletion of endothelial epsin proteins reduced inflammation and attenuated atherosclerosis using both cell culture and mouse models of atherosclerosis.
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Dong, Y., Lee, Y., Cui, K., He, M., Wang, B., Bhattacharjee, S., Zhu, B., Yago, T., Zhang, K., Deng, L., Ouyang, K., Wen, A., Cowan, D. B., Song, K., Yu, L., Brophy, M. L., Liu, X., Wylie-Sears, J., Wu, H., … Chen, H. (2020). Epsin-mediated degradation of IP3R1 fuels atherosclerosis. Nature Communications, 11(1), 3984. https://doi.org/10.1038/s41467-020-17848-4 Cite
Researchers found increases in TNF-α and miR-31/155 levels and reduced numbers of circulating endothelial progenitor cells in patients with preeclampsia.
[Experimental and Molecular Medicine]
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Kim, J.-H., Kim, J.-Y., Park, M., Kim, S., Kim, T., Kim, J., Choi, S., Park, W., Hwang, J. Y., Choe, J., Ha, K.-S., Won, M.-H., Ryoo, S., Kwon, Y.-G., & Kim, Y.-M. (2020). NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-0478-x Cite
Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Investigators showed that an 18 hour exposure of human pulmonary artery endothelial cells to the different nanoparticles modestly affects cellular metabolic activity.
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Scientists positioned the ERAD-associated ubiquitin ligase MARCH6 as a determinant of angiogenic sprouting and barrier integrity through its ability to promote the degradation of the rate-limiting cholesterol biosynthetic enzyme squalene epoxidase.
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Tan, J. M. E., Stoel, M. M. van der, Berg, M. van den, Loon, N. M. van, Moeton, M., Scholl, E., Wel, N. N. van der, Kovačević, I., Hordijk, P. L., Loregger, A., Huveneers, S., & Zelcer, N. (2020). The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting. Cell Reports, 32(5). https://doi.org/10.1016/j.celrep.2020.107944 Cite
Investigators studied a family affected by dilated cardiomyopathy (DCM) due to a frameshift variant in LMNA. Human induced pluripotent stem cell (iPSC)–derived endothelial cells were generated from patients with LMNA-related DCM and phenotypically characterized.
[Science Translational Medicine]
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Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., Gaddam, S., Wang, K. C., Sallam, K., Boyd, J. H., Woo, Y. J., Rabinovitch, M., & Wu, J. C. (2020). Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Science Translational Medicine, 12(554). https://doi.org/10.1126/scitranslmed.aax9276 Cite
Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
Researchers undertook an unbiased discovery approach to identify novel signaling pathways programming sepsis-induced deviant lung angiogenesis. Pulmonary endothelial cells were isolated for RNA-Seq from newborn C57BL/6 mice treated with intraperitoneal lipopolysaccharide to mimic systemic sepsis.
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