Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

ANRIL Promotes the Regulation of Colorectal Cancer on Lymphatic Endothelial Cells via VEGF-C and Is the Key Target for Pien Tze Huang To Inhibit...

[Cancer Gene Therapy] Researchers used network pharmacology, subcutaneous, and orthotopic transplanted colorectal tumor models to determine the effect of Pien Tze Huang on tumor metastasis.

Antibody Blockade of Jagged1 Attenuates Choroidal Neovascularization

[Nature Communications] Scientists reported that targeting the Notch ligand Jagged1 by a monoclonal antibody reduced neovascular lesion size, number of activated phagocytes and inflammatory markers, and vascular leakage in an experimental choroidal neovascularization mouse model.

Endothelial CCRL2 Induced by Disturbed Flow Promotes Atherosclerosis via Chemerin-Dependent β2 Integrin Activation in Monocytes

[Cardiovascular Research] By analyzing scRNA-seq data of the left carotid artery under d-flow and scRNA-seq datasets GSE131776 of ApoE-/- mice, researchers found that CCRL2 was upregulated in one subpopulation of endothelial cells in response to d-flow stimulation and atherosclerosis.

Modulation of lncRNA Links Endothelial Glycocalyx to Vascular Dysfunction of Tyrosine Kinase Inhibitor

[Cardiovascular Research] Investigators performed lncRNA expression profiling to identify potential lncRNAs that were dysregulated in human induced pluripotent stem cell-derived endotheial cells treated with sunitinib.

Fibrillin-1 Regulates Endothelial Sprouting during Angiogenesis

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors revealed that fibrillin-1 was critical for angiogenesis which was compromised by a typical Marfan mutation. In the mouse retina vascularization model, fibrillin-1 was present in the extracellular matrix at the angiogenic front.

Endothelial Cell Telomere Dysfunction Induces Senescence and Results in Vascular and Metabolic Impairments

[Aging Cell] To test whether an abundance of senescent endothelial cells resulted in senescence, researchers selectively reduced the telomere shelterin protein telomere repeat binding factor 2 from endothelial cells of young mice.

BS16 Blood Vessel Organoids Derived from Diabetic Patients Revealed Impaired Function Based on a Subpopulation of Endothelial Cells

[Heart] Blood mononuclear cells from six donors with diabetes and three with non-diabetes were subjected to reprogramming into iPSCs, and subsequent differentiation to vascular organoids.

Genetic Deletion or Tyrosine Phosphatase Inhibition of PTPRZ1 Activates c-Met To Up-Regulate Angiogenesis and Lung Adenocarcinoma Growth

[International Journal of Cancer] Scientists used genetically engineered protein tyrosine phosphatase receptor zeta 1 (PTPRZ1)−/− and Ptprz1+/+ mice to study mechanistic aspects of PTPRZ1 involvement in angiogenesis and investigate its role in lung adenocarcinoma growth.

Endothelial Cell Selectivity to Nanoparticles Depends on Mechanical Phenotype

[Advanced Materials Interfaces] To understand the precise roles of endothelial cell (EC) mechanics and morphology in the uptake of therapeutic nanoparticles by atherogenic endothelium, human aortic ECs were induced to adopt prescribed shapes and areas imposed by microcontact patterned adhesive islands.

Single-Cell RNA-Seq Uncovers Distinct Pathways and Genes in Endothelial Cells during Atherosclerosis Progression

[Frontiers in Molecular Biosciences] ScRNA-seq data of cells from atherosclerotic human coronary arteries were analyzed using the Seurat package. Cell types were clustered, and differentially expressed genes were screened. Gene Set Variation Analysis scores of hub pathways were compared among different cell clusters.

Hypoxia-Induced Reprogramming of Glucose-Dependent Metabolic Pathways Maintains the Stemness of Human Bone Marrow-Derived Endothelial Progenitor Cells

[Scientific Reports] Investigators detected the changes of glucose metabolism and explored its role on maintaining the stemness of bone marrow-derived endothelial progenitor cells under hypoxia.

PRDM16 Regulates Arterial Development and Vascular Integrity

[Frontiers in Physiology] Researchers showed that positive regulatory domain-containing protein 16 (PRDM16), a zinc finger transcription factor, was expressed in arterial endothelial cells (ECs), but not venous ECs in developing embryos and neonatal retinas.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.