Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Branched-Chain Keto-Acid Dehydrogenase Kinase Regulates Vascular Permeability and Angiogenesis to Facilitate Tumor Metastasis in Renal Cell Carcinoma

[Cancer Science] The novel branched-chain keto-acid dehydrogenase kinase /Exosome-miR-125a-5p/VE-cadherin axis regulated intercellular communication between clear cell renal cell carcinoma cells and HUVECs.

A Peptidic Network Antibody Inhibits Both Angiogenesis and Inflammatory Response

[Journal Of Controlled Release] Researchers reported two binding-induced fibrillogenesis peptides as peptidic network antibodies for high-efficient and long-lasting anti-angiogenesis with reduced inflammatory response.

ZIKV Induction of Tristetraprolin in Endothelial and Sertoli Cells Post-Transcriptionally Inhibits IFNβ/λ Expression and Promotes ZIKV Persistence

[mBio] Scientists found that Zika virus (ZIKV) induced IFNβ and IFNλ in human brain microvascular endothelial cells, but post-transcriptionally inhibited IFNβ/IFNλ expression.

Endothelial Sp1/Sp3 Are Essential to the Effect of Captopril on Blood Pressure in Male Mice

[Nature Communications] The authors investigated the role of Sp1 and Sp3 in endothelial cells in vivo and evaluated whether captopril, an angiotensin-converting enzyme inhibitor, targeted Sp1/Sp3 to exert its effects.

Targeting the Microenvironment in the Treatment of Arteriovenous Malformations

[Angiogenesis] Thalidomide and bevacizumab, both VEGF inhibitors, were tested for their ability to prevent the formation of circular networks and proliferation of CD31+ endothelial extracranial arteriovenous malformations cells.

Angiogenesis Inhibitor-Specific Hypertension Increases the Risk of Developing Aortic Dissection

[Biomedicine & Pharmacotherapy] The authors investigated if and how angiogenesis inhibitors increased the onset of aortic dissection using pharmacologically-induced aortic dissection-prone model mice, cultured endothelial cells, and real-world databases.

Endothelial Cell Activation Mediated by Cold Ischemia-Released Mitochondria Is Partially Inhibited by Defibrotide and Impacts on Early Allograft Function following Liver Transplantation

[Biomedicine & Pharmacotherapy] The activation of cultured human umbilical vein endothelial cells was analyzed after challenging with end-ischemic organ preservation solution obtained after cold ischemic storage.

Emerging Nanotechnological Approaches to Regulating Tumor Vasculature for Cancer Therapy

[Journal Of Controlled Release] Scientists describe the morphological and functional characteristics of tumor blood vessels and summarize the pivotal molecular targets commonly used in nanomedicine design, and then highlight the recent cutting-edge advancements utilizing nanotechnologies for precise regulation of tumor vasculature.

Melatonin as a Therapeutic Agent for Alleviating Endothelial Dysfunction in Cardiovascular Diseases: Emphasis on Oxidative Stress

[Biomedicine & Pharmacotherapy] Based on bibliometric studies, the authors first discuss the relationship between oxidative stress-induced endothelial dysfunction and cardiovascular diseases, then summarize the role of melatonin in the treatment of atherosclerosis, hypertension, myocardial ischemia-reperfusion injury, and other cardiovascular diseases.

Google DeepMind’s Protein-Predicting AlphaFold, OCT Imaging Inventors Claim Lasker Awards

[Fierce Biotech] The 2023 winners of the top prizes in biomedical research are emblematic of one of the driving forces of the field: to help see the unseen.

Ultrastructural Features Mirror Metabolic Derangement in Human Endothelial Cells Exposed to High Glucose

[Scientific Reports] The authors employed Cryo Soft X-ray Tomography to obtain 3Dl maps of high D-glucose-treated endothelial cells and their controls at nanometric spatial resolution.

Development and Functional Evaluation of MDR1-Expressing Microvascular Endothelial-Like Cells Derived from Human iPS Cells as an In Vitro Blood-Brain Barrier Model

[Journal Of Pharmaceutical Sciences] To establish an in vitro model of the human blood-brain barrier, MDR1-overexpressing human induced pluripotent stem cells were generated, and were differentiated to MDR1-expressing brain microvascular endothelial-like cells.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.