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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
LSD1/KDM1A and GFI1B Repress Endothelial Fate and Induce Hematopoietic Fate in Induced Pluripotent Stem Cell-Derived Hemogenic Endothelium
[Nature Communications] Investigators examined the role of the transcriptional factor GFI1B and its co-factor LSD1/KDM1A in endothelial- to-hematopoietic transition.
Vascular FLRT2 Regulates Venous-Mediated Angiogenic Expansion and CNS Barriergenesis
[Nature Communications] The authors uncovered the role of the angioneurin fibronectin leucine rich transmembrane protein (FLRT) 2 in central nervous system vascular development in the mouse.
m6A and Beyond: RNA Modifications Shaping Angiogenesis
[Trends in Molecular Medicine] Scientists compile the current understanding of the intricate relationship between various RNA modifications and angiogenic mechanisms, spotlighting emerging evidence that underscore their pivotal regulatory roles in both physiological and pathological angiogenesis.
UBC Medicine Researchers Bridging Evidence and Impact with 2024 Health Research BC Funding
[UBC Faculty of Medicine] Twenty-eight projects led by Faculty of Medicine researchers, including Dr. Liam Brunham, have received new funding from Michael Smith Health Research BC through the 2024 Convening & Collaborating and Reach programs. Dr. Brunham will be studying genetic lipid disorders and premature atherosclerotic cardiovascular disease.
Sexually Dimorphic Differences in Angiogenesis Markers Are Associated with Brain Aging Trajectories in Humans
[Science Translational Medicine] To test the relevance of angiogenesis to human cognitive aging, researchers evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in a pooled two-center sample from deeply phenotyped longitudinal human cohorts.
Endothelial FOSL1 Drives Angiotensin II-Induced Myocardial Injury via AT1R-Upregulated MYH9
[Acta Pharmacologica Sinica] Single-cell sequencing showed angiotensin II induced cytoskeletal pathway enrichment and that FOS like-1 (FOSL1) affected mouse cardiac endothelial dysfunction by pseudotime analysis.
In Vitro Modeling of Atherosclerosis Using iPSC-Derived Blood Vessel Organoids
[Advanced Healthcare Materials] Atherosclerotic blood vessel organoids with a microenvironment associated with atherogenesis, such as shear stress, low-density lipoprotein, pro-inflammatory cytokine, and monocyte co-culture were successfully developed.
Engineering VEGF-Like Peptide QKCMP Promotes Rapid Endothelialization of Blood Vessels
[Journal of Applied Biomaterials & Functional Materials] Zebrafish were treated with different concentrations of QKCMP, and it was found that QKCMP significantly promoted the growth of blood vessels.
Impaired Endothelial Function Contributes to Cardiac Dysfunction – Role of Mitochondrial Dynamics
[American Journal of Physiology-Heart and Circulatory Physiology] Mitochondrial dynamics is an important autoregulatory mechanism that contributes to mitochondrial and endothelial homeostasis and plays a role in formation of reactive oxygen species.
Tumor-Derived Extracellular Vesicles Disrupt the Blood–Brain Barrier Endothelium following High-Frequency Irreversible Electroporation
[Scientific Reports] The authors showed that small tumor-derived extracellular vesicle increase permeability of the blood–brain barrier endothelium after high-frequency irreversible electroporation ablation in vitro.
EphrinB2-Mediated CDK5/ISL1 Pathway Enhances Cardiac Lymphangiogenesis and Alleviates Ischemic Injury by Resolving Post-MI Inflammation
[Signal Transduction and Targeted Therapy] Scientists revealed that erythropoietin-producing hepatoma interactor B2 (EphrinB2) prevented ischemic heart post-myocardial infarction from remodeling and dysfunction by activating the cardiac lymphangiogenesis signaling pathway.
Tumor-Derived EBV-miR-BART2-5p Promotes Nasopharyngeal Carcinoma Metastasis by Inducing Pre-Metastatic Endothelial Cell Pyroptosis
[Molecular Cancer Research] The authors showed that the expression of pyroptosis-associated proteins was greater in the endothelial cells of metastatic nasopharyngeal carcinoma tissues than in those of nontumor tissues.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
