Scientists successfully identified isolated endothelial progenitor cells from the peripheral blood of patients with coronary slow flow.
Previous studies have demonstrated that the expression of several lysine-specific demethylases is induced by hypoxia. The authors investigated the exact mechanisms underlying this regulation and its functional implications for endothelial cell function, such as angiogenesis.
[Arteriosclerosis Thrombosis and Vascular Biology]
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Hsin-Fu Liu Oscar, Kiema Miika, Beter Mustafa, Ylä-Herttuala Seppo, Laakkonen Johanna P., & Kaikkonen Minna U. (n.d.). Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 0(0), ATVBAHA.120.315214. https://doi.org/10.1161/ATVBAHA.120.315214 Cite
Researchers describe the design and synthesis of a panel of fluorinated L-fucose analogs bearing fluorine atoms at the C2 and/or C6 positions of L-fucose as metabolic fucosylation inhibitors. Preliminary study of their effects on cell proliferation revealed that the 6,6-difluoro-L-fucose and 6,6,6-trifluoro-L-fucose showed significant inhibitory activity against proliferation of human colon cancer cells and human umbilical vein endothelial cells.
[ACS Chemical Biology]
Scientists aimed to clarify the direct effects of SAMe on fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells.
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Vergani, L., Baldini, F., Khalil, M., Voci, A., Putignano, P., & Miraglia, N. (2020). New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells. Molecules, 25(18), 4237. https://doi.org/10.3390/molecules25184237 Cite
Researchers showed proof-of-principle modeling of tumor progression and engineered cardiac tissue vascularization. They demonstrated that 3D curvature induced rotation and mixing under laminar flow, leading to unique phenotypic and transcriptional changes in endothelial cells.
To investigate the transcriptomic basis of endothelial cell (EC) specificity, researchers analyzed single-cell RNA-sequencing data from tissue-specific mouse ECs generated by the Tabula Muris consortium.
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Paik David T., Tian Lei, Williams Ian M., Rhee Siyeon, Zhang Hao, Liu Chun, Mishra Ridhima, Wu Sean M., Red-Horse Kristy, & Wu Joseph C. (n.d.). Single-Cell RNA-seq Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.119.041433 Cite
Investigators tested the hypothesis that acute exposure of venous endothelial cells to high shear stress is associated with inflammatory responses that are regulated by NF-κB both in vitro and ex vivo.
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Ward, A. O., Angelini, G. D., Caputo, M., Evans, P. C., Johnson, J. L., Suleiman, M. S., Tulloh, R. M., George, S. J., & Zakkar, M. (2020). NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium. Scientific Reports, 10(1), 15133. https://doi.org/10.1038/s41598-020-71781-6 Cite
THRIL was upregulated in coronary atherosclerotic heart disease (CAD) blood samples and endothelial progenitor cells (EPCs). Knockdown of THRIL in EPCs promoted cell viability, inhibited cell autophagy and further suppressed the development of CAD.
The authors generated induced vascular endothelial cells and smooth muscle cells by direct reprogramming of healthy human fibroblasts from donors of different ages and Hutchinson-Gilford Progeria Syndrome patients.
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To research new treatments for hereditary hemorrhagic telangiectasia – a genetic bleeding disorder in which blood vessels do not form properly – the National Institutes of Health (NIH) has awarded Philippe Marambaud, PhD, professor in the Institute of Molecular Medicine at the Feinstein Institutes for Medical Research, a four-year, $1.675 million grant.
[The Feinstein Institutes]
REGENXBIO Inc. announced that the first patient has been dosed in the AAVIATE trial, a Phase II trial to evaluate the suprachoroidal delivery of RGX-314 using the SCS Microinjector for the treatment of wet age-related macular degeneration.