A Single-Cell Atlas of the Normal and Malformed Human Brain Vasculature

Investigators profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity.
[Science]
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TIRAP Drives Myelosuppression through an Ifnγ–Hmgb1 Axis That Disrupts the Endothelial Niche in Mice

The authors showed that toll/interleukin-1 receptor domain containing adaptor protein (TIRAP) was overexpressed in various types of myelodysplastic syndromes and suppressed all three major hematopoietic lineages.
[Journal of Experimental Medicine]
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Extracellular Vimentin Is an Attachment Factor That Facilitates SARS-CoV-2 Entry into Human Endothelial Cells

The authors described the identification of vimentin, an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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Heterogeneity in Endothelial Cells and Widespread Venous Arterialization during Early Vascular Development in Mammals

Scientists constructed the single-cell transcriptomic landscape of vascular endothelial cells during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos.
[Cell Research]
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VEGF Signaling Causes Stalls in Brain Capillaries and Reduces Cerebral Blood Flow in Alzheimer’s Mice

Scientists reported that VEGF signaling at the luminal side of the brain microvasculature played an integral role in the capillary stalling phenomenon of the APP/PS1 mouse model.
[Brain]
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Targeting Mechanosensitive Endothelial TXNDC5 to Stabilize eNOS and Reduce Atherosclerosis In Vivo

The authors provided experimental evidence demonstrating a previously unidentified causal role of disturbed flow-induced endothelial thioredoxin domain containing 5 (TXNDC5) in atherosclerosis.
[Science Advances]
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Vasomune and AnGes Announce First Patient Enrolled in Phase IIa Clinical Study Evaluating AV-001 for the Treatment of Severe COVID-19 Disease

Vasomune Therapeutics, Inc. announced it has dosed the first patient in the Phase IIa clinical study to evaluate AV-001 in patients hospitalized with severe COVID-19 disease.
[Vasomune Therapeutics, Inc.]
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Compass Therapeutics Announces US FDA Clearance of Investigational New Drug Application for a Phase II Study of CTX-009, a Bispecific Antibody That Simultaneously Targets Delta-like Ligand 4 (DLL4) and Vascular Endothelial Growth Factor A (VEGF-A)

Compass Therapeutics, Inc. announced that the FDA has cleared its IND application for CTX-009, enabling the company to initiate a global Phase II clinical trial for CTX-009 in patients who have advanced Biliary Tract Cancers in the United States and South Korea.
[Compass Therapeutics, Inc.]
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Interplay of Vascular Endothelial Growth Factor Receptors in Organ-Specific Vessel Maintenance

Researchers showed that vascular regression induced by VEGFR2 deletion in postnatal and adult mice was aggravated by additional deletion of VEGFR1 or VEGFR3 in the intestine, kidney, and pancreas, but not in the liver or kidney glomeruli.
[Journal of Experimental Medicine]
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Correction of a Factor VIII Genomic Inversion with Designer-Recombinases

Transient recombinase system treatment of endothelial cells, differentiated from patient-derived induced pluripotent stem cells of a hemophilic donor, resulted in 12% correction of the inversion and restored Factor VIII mRNA expression.
[Nature Communications]
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Hypoxia Increases the Potential for Neutrophil-Mediated Endothelial Damage in COPD

The healthy human neutrophil secretome generated under normoxic or hypoxic conditions was characterized by quantitative mass spectrometry, and the capacity for neutrophil-mediated endothelial damage assessed.
[American Journal of Respiratory and Critical Care Medicine]
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