Scientists positioned the ERAD-associated ubiquitin ligase MARCH6 as a determinant of angiogenic sprouting and barrier integrity through its ability to promote the degradation of the rate-limiting cholesterol biosynthetic enzyme squalene epoxidase.
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Tan, J. M. E., Stoel, M. M. van der, Berg, M. van den, Loon, N. M. van, Moeton, M., Scholl, E., Wel, N. N. van der, Kovačević, I., Hordijk, P. L., Loregger, A., Huveneers, S., & Zelcer, N. (2020). The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting. Cell Reports, 32(5). https://doi.org/10.1016/j.celrep.2020.107944 Cite
Investigators studied a family affected by dilated cardiomyopathy (DCM) due to a frameshift variant in LMNA. Human induced pluripotent stem cell (iPSC)–derived endothelial cells were generated from patients with LMNA-related DCM and phenotypically characterized.
[Science Translational Medicine]
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Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., Gaddam, S., Wang, K. C., Sallam, K., Boyd, J. H., Woo, Y. J., Rabinovitch, M., & Wu, J. C. (2020). Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Science Translational Medicine, 12(554). https://doi.org/10.1126/scitranslmed.aax9276 Cite
Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
Researchers undertook an unbiased discovery approach to identify novel signaling pathways programming sepsis-induced deviant lung angiogenesis. Pulmonary endothelial cells were isolated for RNA-Seq from newborn C57BL/6 mice treated with intraperitoneal lipopolysaccharide to mimic systemic sepsis.
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Investigators established novel oligodendroglioma patient tumor-derived orthotopic xenograft mouse models and cell lines to verify the role of ISL2 in regulating angiogenesis to promote oligodendroglioma growth and malignant transformation.
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Qi, L., Wang, Z.-Y., Shao, X.-R., Li, M., Chen, S.-N., Liu, X.-Q., Yan, S., Zhang, B., Zhang, X.-D., Li, X., Zhao, W., Pan, J.-A., Zhao, B., & Zhang, X.-D. (2020). ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01411-y Cite
Investigators identified key pathways governing meningeal vascular regeneration following head injury. Rapid and complete vascular regeneration in the meninges was predominantly driven by VEGFR2 signaling.
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Deep high-throughput sequencing approach allowed researchers to analyze the miRNA and mRNA expression profiles in HUVECS cultured under gravity, and stimulated microgravity achieved with a clinostat.
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Kasiviswanathan, D., Chinnasamy Perumal, R., Bhuvaneswari, S., Kumar, P., Sundaresan, L., Philip, M., Puthenpurackal Krishnankutty, S., & Chatterjee, S. (2020). Interactome of miRNAs and transcriptome of human umbilical cord endothelial cells exposed to short-term simulated microgravity. Npj Microgravity, 6(1), 1–10. https://doi.org/10.1038/s41526-020-00108-6 Cite
Investigators showed that plasma polymerized nanoparticles, synthesised in reactive gas discharges, could bind and effectively deliver multiple therapeutic cargo in a facile and cost-effective process compatible with up scaled commercial production.
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Michael, P., Lam, Y. T., Filipe, E. C., Tan, R. P., Chan, A. H. P., Lee, B. S. L., Feng, N., Hung, J., Cox, T. R., Santos, M., & Wise, S. G. (2020). Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo. Scientific Reports, 10(1), 12836. https://doi.org/10.1038/s41598-020-69591-x Cite
Many different groups have modified autologous diabetic endothelial-colony-forming cells to improve their function using a variety of methods including pre-treatment with different factors or with genetic modification.
The authors discuss the current knowledge of aryl hydrocarbon receptors mediation on endothelial function and potential mechanisms underlying these actions with a focus on placental endothelial cells.
[Biology of Reproduction]
The authors profiled transcriptomes of blood vascular endothelial cells from peripheral lymph nodes and map phenotypes to the vasculature.
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Brulois, K., Rajaraman, A., Szade, A., Nordling, S., Bogoslowski, A., Dermadi, D., Rahman, M., Kiefel, H., O’Hara, E., Koning, J. J., Kawashima, H., Zhou, B., Vestweber, D., Red-Horse, K., Mebius, R. E., Adams, R. H., Kubes, P., Pan, J., & Butcher, E. C. (2020). A molecular map of murine lymph node blood vascular endothelium at single cell resolution. Nature Communications, 11(1), 1–15. https://doi.org/10.1038/s41467-020-17291-5 Cite
Reports of widespread thromboses and disseminated intravascular coagulation in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. This perspective has critical implications for treatment.
[Nature Reviews Rheumatology]