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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
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Role of Endothelial Dlc1 in Embryonic Vascular Development and Adult Bone Marrow Hematopoiesis
[Leukemia] Scientists uncovered a previously unrecognized role for Deleted in Liver Cancer 1 (Dlc1) in coupling vessel function to hematopoietic cell output, with implications for understanding bone marrow failure syndromes and targeting endothelial dysfunction in hematologic diseases.
Knockdown of Endothelial Serpine1 Improves Stroke Recovery by Attenuating Peri-Infarct Blood Flow and Blood-Brain Barrier Disruption
[Cell Death & Disease] Serpine1 and its protein product Plasminogen Activator-Inhibitor-1 are highly upregulated in endothelial cells after stroke. Researchers hypothesized that inhibiting this pathway within brain endothelial cells could be beneficial for stroke recovery by promoting fibrinolysis and cerebral blood flow.
Endothelial PARP1 Orchestrates Endothelial-to-Mesenchymal Transition via the PARylation of FHL2 in Ischemic Heart Failure
[Acta Pharmacologica Sinica] Investigators identified poly(ADP-ribose) polymerase 1 (PARP1) as a critical driver of endothelial-to-mesenchymal transition in ischemic heart failure.
Aerobic Exercise Activates S1PR1 Signaling in Tumor Endothelial Cells to Promote Vascular Function in Pancreatic Cancer
[Cancer Research] Scientists evaluated surgically resected pancreatic ductal adenocarcinoma (PDAC) from patients who exercised during neoadjuvant chemotherapy to demonstrate that exercise remodeled PDAC vasculature and improved tumor vascular function in patients.
CD4 T Cells Impair Tumor Growth through IL-3 and TNF-Dependent Vascular Damage
[Science] Researchers identified a distinct mode of CD4+ T cell–mediated tumor control that induces inflammatory remodeling of the tumor stroma and disrupts tumor vasculature rather than directly killing cancer cells.
Adenosine Receptor Signaling in Vascular Diseases: From Molecular Mechanisms to Targeted Therapeutics
[Acta Pharmacologica Sinica] The authors summarize the context-dependent functions of adenosine receptors in vascular conditions with particular emphasis on mechanisms associated with endothelial-mesenchymal transition, vascular inflammation, and metabolic reprogramming.
Immunomodulatory Endothelial Cells Contribute to T Cell Recruitment and Activation via Antigen Presentation on MHC II
[Cardiovascular Research] Investigators studied the inflammation-induced emergence of immunomodulatory endothelial cells and characterized their crosstalk with T cells.
Targeting CD4⁺ T Cell Infiltration: Mechanisms and Therapeutic Insights Into CD4⁺ T Cell Transmigration across the Blood-Brain Barrier in Acute Ischemic Stroke
[Fluids and Barriers of the CNS] Scientists examine the functional alterations of the blood-brain barrier induced by different CD4+ T cell subsets in ischemic stroke and explore the associated molecular mechanisms.
Glycine Receptor α2 Mediates Vasodilation via Endothelial eNOS Signaling
[Circulation Research] The authors described a critical role of the α2 subunit of glycine receptor (GLRA2) in modulating endothelial nitric oxide synthase signaling and blood pressure regulation.
Outlook Therapeutics Announces FDA Acceptance of Resubmitted Biologics License Application for ONS-5010/LYTENAVA™ (bevacizumab-vikg) as a Treatment for Wet AMD
[Outlook Therapeutics] Outlook Therapeutics, Inc. announced the US FDA has acknowledged receipt of the resubmission of the Biologics License Application for ONS-5010/LYTENAVA™ for the treatment of neovascular age-related macular degeneration (nAMD), or wet AMD.
4DMT Completes Enrollment for 4FRONT-2 Global Phase III Clinical Trial of 4D-150 in Wet AMD
[4D Molecular Therapeutics] 4D Molecular Therapeutics announced enrollment completion for 4FRONT-2, the second Phase III clinical trial in their global program, evaluating 4D-150 in patients with wet age-related macular degeneration (wet AMD).
CytoDyn Announces First Patient Dosed in Phase IIa Study in Collaboration with Weill Cornell Medicine Evaluating Leronlimab in Alzheimer’s Disease
[CytoDyn, Inc.] CytoDyn, Inc. announced that the first patient has been dosed in a Phase IIa clinical study evaluating leronlimab in patients with Alzheimer’s disease, in collaboration with Weill Cornell Medicine.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
