Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia

January 24, 2025

[Circulation Research] Investigators used placentae from normotensive and preeclampsia pregnancy cohorts, human H9 embryonic stem cells differentiated into cytotrophoblast-like cells, and placenta-specific Phd2−/− preeclamptic mice.

A Carnitine Transporter at the Blood–Brain Barrier Modulates Sleep via Glial Lipid Metabolism in Drosophila

January 23, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Using a genetic screen in fruit flies, scientists found that reducing the activity of the carnitine transporter CG6126 at the blood-brain barrier decreased sleep by causing lipid accumulation.

IFN-γ Reprograms Cardiac Microvascular Endothelial Cells to Mediate Doxorubicin Transport and Influences the Sensitivity of Mice to Doxorubicin-Induced Cardiotoxicity

January 22, 2025

[Experimental & Molecular Medicine] Investigators constructed a mouse model of doxorubicin (DOX)-induced cardiotoxicity (DIC) using DOX to investigate potential mechanisms contributing to the differential susceptibility to DIC.

Adenosine Diphosphate Stimulates VEGF-Independent Choroidal Endothelial Cell Proliferation: A Potential Escape from Anti-VEGF Therapy

January 22, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Researchers characterized adenosine diphosphate (ADP)'s bioactivity on eye-derived endothelial cell (EC). Single-cell transcriptomics from human choroidal datasets showed a strong expression of P2RY1 in EC.

PCDH17 Induces Colorectal Cancer Metastasis by Destroying the Vascular Endothelial Barrier

January 21, 2025

[Cell Death & Disease] Protocadherin 17 (PCDH17) expression was higher in the vascular endothelial cells of colon cancer with distant metastasis, and the rates of PCDH17+ endothelial cells was associated with the M stage in clinical pathological characteristics analysis.

Parthenolide Improves Sepsis-Induced Coagulopathy by Inhibiting Mitochondrial-Mediated Apoptosis in Vascular Endothelial Cells through BRD4/BCL-XL Pathway

January 20, 2025

Scientists utilized septic rats and lipopolysaccharide-stimulated vascular endothelial cells to simulate a sepsis-induced coagulopathy model and observed the therapeutic effects of parthenolide. [nan] Full Article

Intratumoral Collagen Deposition Supports Angiogenesis Suggesting Anti-angiogenic Therapy in Armored and Cold Tumors

January 20, 2025

[Advanced Science] The authors systematically analyzed the association between immuno-collagenic subtypes and angiogenesis across diverse cancer types.

Hypoxia Combined with Interleukin-17 Regulates Hypoxia-Inducible Factor-1α/Endothelial Nitric Oxide Synthase Expression in Pulmonary Artery Endothelial Cells

January 20, 2025

[Journal of Cellular and Molecular Medicine] Researchers explored alterations in pulmonary artery endothelial cells under the hypoxic and elevated interleukin-17 conditions that were commonly present in patients with chronic thromboembolic pulmonary hypertension.

Feedback Loop Centered on MAF1 Reduces Blood–Brain Barrier Damage in Sepsis-Associated Encephalopathy

January 20, 2025

[Cellular & Molecular Biology Letters] A rat sepsis model was constructed using the cecum ligation and puncture method. In vitro, rat brain microvascular endothelial cells and astrocytes were stimulated with serum from the sepsis model rats.

Unveiling the Immunomodulatory Dance: Endothelial Cells’ Function and Their Role in Non-Small Cell Lung Cancer

January 20, 2025

[Molecular Cancer] Investigators provide insights into the complex interplay between tumor endothelial cells and the immune system in non-small cell lung cancer including discussion of potential optimized therapeutic opportunities.

Concept Medical Announces First Patient Enrollment in the MAGICAL BTK IDE Trial, Launching its PAD Clinical Program in the United States

January 20, 2025

[Concept Medical Inc. (Canada Newswire)] Concept Medical Inc. announced the enrolment of the first patient in the "MAGICAL BTK" US Investigational Device Exemption pivotal trial.

Endothelial STING-JAK1 Interaction Promotes Tumor Vasculature Normalization and Antitumor Immunity

January 17, 2025

[Journal of Clinical Investigation] Researchers demonstrated that endothelial STING expression was critical for STING agonist–induced antitumor activity.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.