Category Archives: Endothelial Cell

Endothelial Cell News is an online publication and email newsletter dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
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Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

Clovis Oncology Announces First Patient Enrolled in the Phase II Portion of the LIO-1 Trial Evaluating the Combination of Lucitanib and Opdivo in Gynecologic Cancers

Clovis Oncology, Inc. announcedtreatment of the first patient in the Phase II portion of the LIO-1 trial evaluating the combination of lucitanib, Clovis’ investigational angiogenesis inhibitor, including VEGFR1-3, and Opdivo®, Bristol Myers Squibb’s PD-1 inhibitor, for the treatment of gynecologic cancers.
[Clovis Oncology, Inc.]
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Aerpio Pharmaceuticals, Inc. Announces a Second Clinical Trial with Funding from MTEC to Evaluate Razuprotafib for the Prevention and Treatment of ARDS in Patients with Moderate to Severe COVID-19

Aerpio Pharmaceuticals, Inc. and the US Government operating through the Medical Technology Enterprise Consortium announced that an agreement has been reached to evaluate razuprotafib in a new randomized, investigational trial for the prevention and treatment of Acute Respiratory Distress Syndrome (ARDS) in adult patients with moderate to severe COVID-19.
[Aerpio Pharmaceuticals, Inc. ]
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Enhancing Myocardial Repair with CardioClusters

Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
[Nature Communications]
Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-z Cite
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The Microscopic Anatomy of Endothelial Cells in Human Atherosclerosis: Focus on ER and Mitochondria

The author investigated the microscopic architecture of endothelial cells in human atherosclerosis and to determine whether the potential structural abnormalities of endoplasmic reticulum and mitochondria may play a central pathogenic role in atherogenesis or may merely reflect the condition of a tissue whose integrity has already been disturbed or destroyed.
[Journal of Anatomy]
Perrotta, I. (n.d.). The microscopic anatomy of endothelial cells in human atherosclerosis: Focus on ER and mitochondria. Journal of Anatomy, n/a(n/a). https://doi.org/10.1111/joa.13281 Cite
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Epsin-Mediated Degradation of IP3R1 Fuels Atherosclerosis

Scientists showed that deletion of endothelial epsin proteins reduced inflammation and attenuated atherosclerosis using both cell culture and mouse models of atherosclerosis.
[Nature Communications]
Dong, Y., Lee, Y., Cui, K., He, M., Wang, B., Bhattacharjee, S., Zhu, B., Yago, T., Zhang, K., Deng, L., Ouyang, K., Wen, A., Cowan, D. B., Song, K., Yu, L., Brophy, M. L., Liu, X., Wylie-Sears, J., Wu, H., … Chen, H. (2020). Epsin-mediated degradation of IP3R1 fuels atherosclerosis. Nature Communications, 11(1), 3984. https://doi.org/10.1038/s41467-020-17848-4 Cite
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NF-κB-Dependent miR-31/155 Biogenesis Is Essential for TNF-α-Induced Impairment of Endothelial Progenitor Cell Function

Researchers found increases in TNF-α and miR-31/155 levels and reduced numbers of circulating endothelial progenitor cells in patients with preeclampsia.
[Experimental and Molecular Medicine]
Kim, J.-H., Kim, J.-Y., Park, M., Kim, S., Kim, T., Kim, J., Choi, S., Park, W., Hwang, J. Y., Choe, J., Ha, K.-S., Won, M.-H., Ryoo, S., Kwon, Y.-G., & Kim, Y.-M. (2020). NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-0478-x Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Gold Nanoparticles Disrupt Actin Organization and Pulmonary Endothelial Barriers

Investigators showed that an 18 hour exposure of human pulmonary artery endothelial cells to the different nanoparticles modestly affects cellular metabolic activity.
[Scientific Reports]
Sinclair, W. E., Chang, H.-H., Dan, A., Kenis, P. J. A., Murphy, C. J., & Leckband, D. E. (2020). Gold nanoparticles disrupt actin organization and pulmonary endothelial barriers. Scientific Reports, 10(1), 13320. https://doi.org/10.1038/s41598-020-70148-1 Cite
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The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

Scientists positioned the ERAD-associated ubiquitin ligase MARCH6 as a determinant of angiogenic sprouting and barrier integrity through its ability to promote the degradation of the rate-limiting cholesterol biosynthetic enzyme squalene epoxidase.
[Cell Reports]
Tan, J. M. E., Stoel, M. M. van der, Berg, M. van den, Loon, N. M. van, Moeton, M., Scholl, E., Wel, N. N. van der, Kovačević, I., Hordijk, P. L., Loregger, A., Huveneers, S., & Zelcer, N. (2020). The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting. Cell Reports, 32(5). https://doi.org/10.1016/j.celrep.2020.107944 Cite
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Clinical Trial in a Dish Using iPSCs Shows Lovastatin Improves Endothelial Dysfunction and Cellular Cross-Talk in LMNA Cardiomyopathy

Investigators studied a family affected by dilated cardiomyopathy (DCM) due to a frameshift variant in LMNA. Human induced pluripotent stem cell (iPSC)–derived endothelial cells were generated from patients with LMNA-related DCM and phenotypically characterized.
[Science Translational Medicine]
Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., Gaddam, S., Wang, K. C., Sallam, K., Boyd, J. H., Woo, Y. J., Rabinovitch, M., & Wu, J. C. (2020). Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Science Translational Medicine, 12(554). https://doi.org/10.1126/scitranslmed.aax9276 Cite
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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FOSL1 Is a Novel Mediator of Endotoxin/Lipopolysaccharide-Induced Pulmonary Angiogenic Signaling

Researchers undertook an unbiased discovery approach to identify novel signaling pathways programming sepsis-induced deviant lung angiogenesis. Pulmonary endothelial cells were isolated for RNA-Seq from newborn C57BL/6 mice treated with intraperitoneal lipopolysaccharide to mimic systemic sepsis.
[Scientific Reports]
Nitkin, C. R., Xia, S., Menden, H., Yu, W., Xiong, M., Heruth, D. P., Ye, S. Q., & Sampath, V. (2020). FOSL1 is a novel mediator of endotoxin/lipopolysaccharide-induced pulmonary angiogenic signaling. Scientific Reports, 10(1), 13143. https://doi.org/10.1038/s41598-020-69735-z Cite
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