Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension

[Circulation Research] Researchers studied cyclophilin D (CypD) acetylation in patients with essential hypertension, defined a pathogenic role of CypD acetylation in deacetylation mimetic CypD-K166R mutant mice and endothelial-specific general control of amino acid synthesis 5 like 1–deficient mice using an angiotensin II model of hypertension.

Brain Endothelial GSDMD Activation Mediates Inflammatory BBB Breakdown

[Nature] Scientists found that activation of the pore-forming protein GSDMD by the cytosolic lipopolysaccharide (LPS) sensor caspase-11, but not by TLR4-induced cytokines, mediated BBB breakdown in response to circulating LPS or during LPS-induced sepsis.

Haplo-Insufficiency of Profilin1 in Vascular Endothelial Cells Is Beneficial but Not Sufficient to Confer Protection against Experimentally Induced Atherosclerosis

[Cytoskeleton] The authors investigated the impact of endothelial cell-specific partial loss of profilin1 expression in atherosclerosis development.

SARS-CoV-2 Infection Activates Inflammatory Macrophages in Vascular Immune Organoids

[Scientific Reports] The authors established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection.

Glutamatergic Neuronal Activity Regulates Angiogenesis and Blood-Retinal Barrier Maturation via Norrin/β-Catenin Signaling

[Neuron] Using in vivo genetic studies in mice, scRNA-seq, and functional validation, researchers showed that deep plexus angiogenesis and paracellular blood-retinal barrier maturation were delayed in Vglut1−/− retinas where neurons failed to release glutamate.

Endomucin Selectively Regulates Vascular Endothelial Growth Factor Receptor-2 Endocytosis through Its Interaction with AP2

[Cell Communication and Signaling] The authors investigated the molecular mechanism underlying endomucin’s involvement in the regulation of vascular endothelial growth factor-induced endocytosis.

Anti-Lymphangiogenesis for Boosting Drug Accumulation in Tumors

[Signal Transduction and Targeted Therapy] Investigators verified that anlotinib, a tyrosine kinase inhibitor with anti-lymphangiogenesis activity, and SAR131675, a selective VEGFR-3 inhibitor, effectively decreased the density of tumor lymphatic vessels in mouse cancer models.

Canonical and Non-Canonical Roles of Complement in Atherosclerosis

[Nature Reviews Cardiology] Scientists summarize the classical and the emerging non-classical roles of the complement system in the pathogenesis of atherosclerosis.

NYU Langone Health’s New Optimal Aging Institute to Further Explore the Link Between Vascular Health & Aging

[NYU Langone Health] Researchers at the newly formed Optimal Aging Institute at NYU Langone Health have been awarded $31 million by the National Institutes of Health to study how vascular risk factors contribute to dementia and other age-related disorders in those over the age of 85, building upon existing research.

Endothelial DR6 in Blood-Brain Barrier Malfunction in Alzheimer’s Disease

[Cell Death & Disease] Investigators found that brain endothelial death receptor 6 (DR6) levels were significantly reduced in a murine model of Alzheimer's disease at the onset of amyloid-β accumulation.

The Requirement of the Mitochondrial Protein NDUFS8 for Angiogenesis

[Cell Death & Disease] The authors investigated the potential involvement of NADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8) in angiogenesis. In HUVECs and other endothelial cell types, they employed viral shRNA to silence NDUFS8 or employed the CRISPR/Cas9 method to knock it out.

CD32 Captures Committed Haemogenic Endothelial Cells during Human Embryonic Development

[Nature Cell Biology] Researchers performed transcriptomic analysis of 28- to 32-day human embryos and observed that the expression of Fc receptor CD32 was highly enriched in the endothelial cell population that contained hemogenic endothelial cells.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.