Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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A Single-Cell Time-Series Atlas of Endothelial Cell Embryonic Development

February 23, 2026

[Cell] Researchers generated a time-series endothelial resource covering the entirety of mouse embryonic development, including 26 time points and 8 organs.

STING-Induced Blood-Brain Barrier Opening Combined with Radiotherapy Potentiates Antitumor Response in a High-Grade Glioma Model

February 23, 2026

[Journal of Clinical Investigation] 8803, a potent STING pathway agonist, combined with radiation therapy triggers distinctive antiglioma immune reactivity, facilitates blood-brain barrier opening, and warrants consideration for up-front clinical trials in glioblastoma, where treatment effects can be monitored using [18F]-FLT PET imaging.

RAB3GAP2 Is a Regulator of Skeletal Muscle Endothelial Cell Proliferation and Associated with Capillary-to-Fiber Ratio

February 23, 2026

[Cell Reports] Experimental reduction of RAB3GAP2 in human endothelial cells led to increased proliferation and tube formation in vitro, regulation of secreted factors promoting angiogenesis and T cell activation, and increased in vivo endothelial cell density in mice.

Retinal Arterial Vasospasm in Retinal Vein Occlusion and Its Association with Aqueous Humor Endothelin-1

February 23, 2026

[Ophthalmology and Therapy] To determine the incidence, clinical characteristics, and spatial associations of retinal arterial vasospasm in retinal vein occlusion, and to explore its relationship with aqueous humor endothelin-1 concentration.

Renal-Vascular Axis: Unmasking Its Role in Vascular Endothelial Growth Factor-Inhibitor Vascular Toxicity in Cancer Patients

February 23, 2026

[British Journal of Pharmacology] The authors clarify the contribution of the renal-vascular axis to vascular endothelial growth factor inhibitor-related toxicity, focusing on key mechanisms such as endothelial dysfunction, activation of the renin-angiotensin-aldosterone system, oxidative stress, and disrupted glomerular filtration.

Ocular Therapeutix™ Reports Positive Results from Landmark SOL-1 Phase III Superiority Trial in Wet AMD

February 23, 2026

[Ocular Therapeutix, Inc.] Ocular Therapeutix, Inc. announced positive topline results from the SOL-1 Phase III superiority trial of AXPAXLI, its investigational product candidate, for the treatment of wet age-related macular degeneration (AMD).

Loss of Angiopoietin-2 Leads to Region-Specific Brain Malformations and Blood-Brain Barrier Leakage

February 23, 2026

[JCI Insight] Scientists showed that loss of angiopoietin-2 leads to region-specific vascular malformations and blood-brain barrier dysfunction, resulting in differential permeability to 1 kDa and 70 kDa fluorescent tracers.

Human Subcutaneous Derived Stromal Vascular Fraction Endothelial Cells Display Venous and Arterial Markers in Culture and 3D Capillaries

February 12, 2026

[Tissue Engineering and Regenerative Medicine] Researchers investigated endothelial cells from the stromal vascular fraction of human subcutaneous white adipose tissue in 2D culture and 3D bioengineered skin models to better define their specific subtypes.

Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells, and Impairs Late Cortical Angiogenesis

February 12, 2026

[Journal of Neurochemistry] Scientists investigated whether ethanol-induced effects on endothelial cells involve epigenetic reprogramming, specifically through alterations in DNA methylation profiles.

Endothelial IRE1 Signaling Maintains Blood-Brain Barrier Integrity and Limits Neuroinflammation after Traumatic Brain Injury

February 12, 2026

[Cell Death & Disease] The authors investigated the role of endothelial IRE1 signaling in traumatic brain injury using endothelial cell-specific IRE1 conditional knockout mice subjected to cortical ablation.

Endothelial TRIM47 Regulates Blood-Brain Barrier Integrity and Cognition via the KEAP1/NRF2 Signaling Pathway in Mice

February 12, 2026

[Communications Biology] Investigators devised a multilayered experimental plan to decipher the biological mechanisms underlying TRIM47’s role in cerebral small vessel disease pathophysiology.

GlycoRNA Complexed with Heparan Sulfate Regulates VEGF-A Signaling

February 10, 2026

[Nature] Researchers uncovered a previously unrecognized regulatory axis by which cell surface ribonucleoproteins negatively modulate heparan sulfate-mediated signalling in the context of angiogenesis driven by VEGF-A.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.