Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Role of Advanced Glycation End Products in Diabetic Vascular Injury: Molecular Mechanisms and Therapeutic Perspectives

[European Journal Of Medical Research] The authors discuss the formation and accumulation of advanced glycation end products and the subsequent activation of signaling pathways leading to oxidative stress, inflammation, endothelial dysfunction, smooth muscle cell proliferation, extracellular matrix remodeling, and impaired angiogenesis.

NIH Puts Hold on $30 Million Trial of Potential Stroke Drug

[Science] The NIH has paused the start of a major human trial of an experimental drug aimed at protecting the brain after a stroke and launched an investigation into recently aired concerns about the drug’s safety and whether lab studies supporting its promise contain manipulated images and data.

Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence from Lineage Tracing Mice and Cultured Cells

[Arteriosclerosis Thrombosis And Vascular Biology] Researchers used human and mouse aortic endothelial cell (EC) as well as EC-lineage tracing atherosclerotic Apoe–/– mice to investigate the biological sexual dimorphism of the EC functions in vitro and in vivo.

Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease

[Circulation Research] Scientists explored a novel hypothesis that acute ceramide formation through neutral sphingomyelinase is necessary for maintaining nitric oxide signaling within the human microvascular endothelium.

Single Nuclei Transcriptomics in Diabetic Mice Reveals Altered Brain Hippocampal Endothelial Cell Function, Permeability, and Behavior

[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Investigators used single nuclei RNA sequencing technology to profile the transcriptome of endothelial cells (EC) from anatomically defined hippocampus of db/db mice to identify differentially expressed genes, gene pathways, and networks.

Fingolimod (FTY720), an FDA-Approved Sphingosine 1-Phosphate (S1P) Receptor Agonist, Restores Endothelial Hyperpermeability in Cellular and Animal Models of Dengue Virus Serotype 2 Infection

[Iubmb Life] Scientists explored whether FTY720 treatment can alleviate DENV-induced endothelial hyperpermeability. In functional assays, in both in vitro systems and in AG129 animal models, FTY720 treatment was found effective.

Integrated Systems Biology Approach Identifies Gene Targets for Endothelial Dysfunction

[Molecular Systems Biology] Investigators found 26 genes that, upon silencing, exacerbated the endothelial dysfunction (ED) phenotypes tested, and network propagation identified a pro-ED network enriched in functions associated with inflammatory responses.

Vasculature-on-a-Chip with a Porous Membrane Electrode for In Situ Electrochemical Detection of Nitric Oxide Released from Endothelial Cells

[Analytical Chemistry] A porous gold membrane electrode was placed directly beneath the cells for in situ and real-time measurements of nitrous oxide.

PI3K-C2β Limits mTORC1 Signaling and Angiogenic Growth

[Science Signaling] Using in vivo and in vitro approaches, researchers found that PI3K-C2β was a critical regulator of blood vessel growth by restricting endothelial mTORC1 signaling.

Magneto-Mechanical Actuation Induces Endothelial Permeability

[ACS Biomaterials Science & Engineering] Scientists proposed an innovative method based on magneto-mechanical actuation to induce endothelial permeability. This method employed FDA-approved PEGylated superparamagnetic iron oxide nanoparticles and alternating nonheating magnetic fields.

Characterization of Patient-Derived GNAQ Mutated Endothelial Cells from Capillary Malformations

[Journal Of Investigative Dermatology] In a mono-centre exploratory study of 17 adult patients with capillary malformations, scientists found somatic mutations in the GNAQ or GNA11 genes. They applied an endothelial-selective cell isolation protocol to culture primary endothelial cells from skin biopsies from these patients.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.