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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
TrkB Signaling Promotes Alveolar Capillary Angiogenesis Following Perinatal Hyperoxic Damage
[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors determined whether TrkB signaling is required for perinatal general capillary cell proliferation and pulmonary angiogenesis in a hyperoxia mouse bronchopulmonary dysplasia model.
IL-6 Induces Mitochondrial ROS Production and Blunts NO Bioavailability in Human Aortic Endothelial Cells
[American Journal of Physiology-Regulatory Integrative and Comparative Physiology] Scientists tested the hypothesis that IL-6 induced mitochondrial reactive oxygen species (ROS) production and blunted nitric oxide (NO) bioavailability in endothelial cells.
Dynamic Cytoskeletal Regulation of Cell Shape Supports Resilience of Lymphatic Endothelium
[Nature] Researchers identified dynamic cytoskeletal regulation of lymphatic endothelial cells shape, induced by isotropic stretch, as crucial for the integrity and function of dermal lymphatic capillaries.
Roles of TLR4 in Macrophage Immunity and Macrophage-Pulmonary Vascular/Lymphatic Endothelial Cell Interactions in Sepsis
[Communications Biology] Scientists uncovered that toll-like receptor 4 (TLR4) operated through multiple pathways in endothelial dysfunction: macrophage TLR4 mediated inflammatory damage to endothelial cells (ECs) and lymphatic ECs while endothelial TLR4 both directly sensitized cells to lipopolysaccharide-induced injury.
Embryonic Reprogramming of the Tumor Vasculature Reveals Targets for Cancer Therapy
[Proceedings of The National Academy of Sciences of The United States of America] An approach for identification of highly selective tumor endothelial markers was conducted to develop targeted antiangiogenic immunotherapies.
Single-Cell Atlas of Endothelial and Mural Cells across Primary and Metastatic Brain Tumors
[Immunity] Scientists analyzed the two major blood-brain barrier cell types, endothelial and mural cells, across non-tumor brain tissue, isocitrate dehydrogenase (IDH) mutant low-grade gliomas, IDH wild-type high-grade glioblastomas, and brain metastases from various primary tumors.
Endothelial TDP-43 Depletion Disrupts Core Blood-Brain Barrier Pathways in Neurodegeneration
[Nature Neuroscience] Researchers identified a disease-associated subset of capillary endothelial cells in Alzheimer’s disease, amyotrophic lateral sclerosis and frontotemporal degeneration. These capillaries exhibited reduced nuclear β-catenin and β-catenin-downstream genes, along with elevated TNF/NF-κB markers.
Extravasation of Borrelia burgdorferi Across the Blood–Brain Barrier is an Extremely Rare Event
[Advanced Science] To determine how Borrelia burgdorferi (Bb) extravasate from circulation and whether Bb can cross the blood–brain barrier, researchers imaged Bb-microvessel interactions in non-tissue-specific and brain-specific tissue-engineered microvessel models perfused with GFP-labeled Bb.
Diagonal Therapeutics Initiates Natural History Study of Adults Living with Hereditary Hemorrhagic Telangiectasia (HHT), a Rare Bleeding Disorder with No Approved Treatments
[Diagonal Therapeutics] Diagonal Therapeutics announced the initiation of a natural history study for HTT in partnership with patient advocacy group Cure HHT. This non-interventional, observational, longitudinal evaluation aims to characterize the variability of patient-reported outcomes, including epistaxis, hematologic support, and quality of life.
The Pathways for Nanoparticle Transport across Tumor Endothelium
[Nature Nanotechnology] The authors discovered that tumor endothelial cell membrane ruffles captured circulating nanoparticles, internalized them in intracellular vesicles and released them into the tumour interstitium.
ARNT-Dependent HIF-2α Signaling Protects Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction
[Communications Biology] Investigators revealed that endothelial Hif2α deletion led to increased cardiac microvascular permeability, disrupted barrier function, and elevated IL-6 expression in endothelial cells.
Mapping the Transcriptional and Epigenetic Landscape of Organotypic Endothelial Diversity in the Developing and Adult Mouse
[Nature Cardiovascular Research] Investigators profiled the accessible chromatin and transcriptional landscapes of the endothelium from the mouse liver, lung, heart, kidney, brain and retina, across developmental time, to identify potential transcriptional regulators of endothelial heterogeneity.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
