Vascular Mimicry as a Facilitator of Melanoma Brain Metastasis

Scientists found that vascular mimicry density was elevated in melanoma brain metastases compared to paired extracranial specimens and was associated with tumor volume and central nervous system edema. Their studies indicated a relevant role of YAP and TAZ, two transcriptional co-factors scarcely studied in melanoma, in tumor cell-vasculogenesis and in brain metastasis.