Scientists generated a cardiac ventricular myocyte-specific developmental deletion of Vdac2 in mice and indicated that loss of VDAC2 in the myocardium caused severe impairment in excitation-contraction coupling by altering both intracellular and mitochondrial calcium signaling.
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Researchers used mouse ESCs, which grew in 3D colonies, as a model to investigate division in 3D and observed that, at the periphery of 3D colonies, ESCs displayed high spindle mobility and divided asymmetrically.
[Journal of Cell Science]
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Scientists performed mitochondrial DNA deep sequencing during the transition from parental fibroblasts to reprogrammed iPSCs and to differentiated neuronal precursor cells obtained from controls and patients affected by mitochondrial disorders.
[Stem Cell Reports]
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BlueRock Therapeutics LP announced that the US FDA has granted Fast Track designation for DA01 for advanced Parkinson’s disease. DA01, BlueRock’s PSC-derived dopaminergic neuron therapy, is under evaluation in a Phase I study.
[BlueRock Therapeutics LP]
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Investigators devised a strategy to enhance maturation of otic progenitor cells toward human hair cell–like cells by assembling 3D otic organoids that contain human pluripotent stem cell-derived otic cells, endothelial cells, and mesenchymal stem cells.
[Cell and Tissue Research]
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The authors provided a detailed directed differentiation protocol to generate induced basal cells (iBCs) from human PSCs. iBCs recapitulated biological and functional properties of airway basal cells including mucociliary differentiation in vitro or in vivo in tracheal xenografts, facilitating the study of inherited and acquired diseases of the airway.
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The authors showed dynamic changes in the buoyant density and abundance of extracellular vesicles that were secreted by PC12 cells stimulated with nerve growth factor, N2A cells treated with retinoic acid to induce neural differentiation, and mouse ESCs differentiated into neuronal cells.
[Journal of Cell Biology]
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Researchers generated human-iPSCs depleted in MBNL proteins and evaluated the consequences of their losses on the generation of skeletal muscle cells.
[Human Molecular Genetics]
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Scientists developed a simplified method to generate iPSC-derived human microglia and transplanted them into the brain via a transnasal route in immunocompetent mice, in combination with a colony stimulating factor 1 receptor antagonist.
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Various factors were precisely modulated to facilitate differentiation of human iPSCs into dental epithelial cells, which are essential for the regeneration of functional teeth.
[Cell and Tissue Research]
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Investigators developed a non-invasive label-free live cell imaging platform to predict the efficiency of human PSC (hPSC) differentiation into cardiomyocytes. Autofluorescence imaging of metabolic co-enzymes was performed under varying differentiation conditions across five hPSC lines.
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