ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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FUJIFILM Cellular Dynamics Launches New iPSC Manufacturing Facility in Madison

June 3, 2026

[FUJIFILM Cellular Dynamics, Inc.] FUJIFILM Cellular Dynamics, Inc. celebrated the opening of its new headquarters and iPSC development and manufacturing facility in its Madison home. The new site is expected to quadruple the capacity for the company’s iPSC-based research products and services manufacturing footprint and expand capabilities across FUJIFILM Cellular Dynamics’ research product portfolio.

Reversible Superdeformability of hiPSC Epithelial Cortinoids

June 3, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Scientists highlighted how spherical epithelial shells, formed from hiPSCs, achieve “superdeformability” through reversible bending and tilting of their lateral cell edges.

Cryopreservable Dopaminergic Progenitors Derived from Human iPSCs with Accelerated Loss of Pluripotency and Early Functional Restoration in Parkinsonian Rats

June 3, 2026

[NPJ Parkinson'S Disease] Investigators developed an optimized protocol building upon our previously established neural induction method, with further refinements, to efficiently convert iPSCs into midbrain dopaminergic neurons.

Replication Stress Primes a Trophectoderm Fate in Embryonic Stem Cells

June 3, 2026

[Cell Death Discovery] Using mESC as an inner cell mass model, the authors showed that replication stress rapidly and durably induces trophoectoderm regulators, including Cdx2, Gata3, Eomes, Elf5, Hand1, and Tfap2c.

Embryotoxicity of Pyrethroid Insecticides and Their Mixtures in a Human Induced Pluripotent Stem Cell-Based Model In Vitro

June 3, 2026

[Archives of Toxicology] Researchers evaluated the effects and potential mechanism of selected pyrethroids and their common metabolite 3-PBA on cardiomyocyte differentiation.

Epigenomic Regulation of Neural Crest Differentiation in Human-Induced Pluripotent Stem Cells

June 3, 2026

[iScience] Investigators used a hiPSC model to compare differentiation of cranial neural crest cells (NCCs) and trunk NCCs and define lineage specific mechanisms.

Glycine: The Missing Link between Carbohydrate and Xenobiotic Metabolism in the Maturing Human Hepatocyte

June 3, 2026

[iScience] Researchers examined the remodeling of central and xenobiotic metabolism during the glycine-supplemented differentiation of iPSCs into hepatocyte-like cells and HepG2 into a metabolically active form.

Generation of Therapeutic T Cells from Human Induced Pluripotent Stem Cells

June 3, 2026

[Inflammation and Regeneration] Scientists outline their research trajectory, transitioning from the foundational autologous “T-iPSC” concept to scalable, “off-the-shelf” allogeneic strategies.

Induced Pluripotent Stem Cell-Derived NK Cells As an Off-the-Shelf Platform for Cancer Immunotherapy: Opportunities, Challenges, and Clinical Translation

June 3, 2026

[Stem Cell Reviews and Reports] The authors summarize current strategies for iPSC-to- natural killer differentiation, spanning feeder-based systems, feeder-free protocols, embryoid body approaches, and scalable GMP-compatible manufacturing methods.

15 Million for Research on Cell Therapy for Parkinson’s Disease

May 20, 2026

[Karolinska Institutet] Karolinska Institutet has received a grant of DKK 10 million (approximately SEK 15 million) from the Novo Nordisk Foundation for research on cell therapy for Parkinson’s disease. The project is led by Johan Ericson, professor at the Department of Cell and Molecular Biology.

Variant U1 snRNAs Contribute to Cell Cycle and Differentiation Control of Human iPS Cells

May 20, 2026

[Nature Communications] Researchers focused on the understudied paralogs of the U1 small nuclear RNA gene known as variant U1 snRNAs. By generating isogenic knockout lines of hiPSCs for different variant U1s, they showed that their loss profoundly changes both gene expression and cell cycle profiles.

Reversible Superdeformability of hiPSC Epithelial Cortinoids

May 20, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Using inflation–deflation assays and high-resolution imaging, scientists found that these fluid-filled shells are weakly pressurized and achieve extreme deformability through reversible soft modes of deformation accommodated by the cytoskeleton.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.