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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
A Pluripotent Stem Cell Atlas of Multilineage Differentiation
[Scientific Data] Researchers generated a single-cell RNA sequencing time course to study the role of developmental signaling pathways on multilineage diversification from pluripotency in vitro.
DNA Aptamer-Guided Glycomimetics for Developmental Stage-Specific Glycocalyx Engineering to Control Stem Cell Differentiation
[Journal of The American Chemical Society] Scientists reported a heparan sulfate mimetic containing a DNA aptamer with affinity for the membrane-associated pluripotency marker, alkaline phosphatase, that can be selectively targeted to the surface of ESCs.
Human Neuron Subtype Programming via Single-Cell Transcriptome-Coupled Patterning Screens
[Science] Investigators modulated developmental signaling pathways combined with transcripiton factor overexpression to explore the spectrum of neuron subtypes generated from PSCs.
Analysis of a BCOR Internal Tandem Duplication in Mouse Embryonic Stem Cell to Neuronal Precursor Differentiation
[Genetics] To dissect the molecular mechanisms underlying aberrant function of BCL-6 corepressor (BCOR)-internal tandem duplication (ITD) mutants, scientists employed mESCs expressing either transgenic or endogenous BCOR-ITD.
State-of-the-Art: Somatic Cell Sources Used for the Generation of Human Induced Pluripotent Stem Cells
[Stem Cells and Development] The authors address the current state of research dealing with different sources of human somatic cells used for the generation of iPSCs.
Advances, Challenges, and Opportunities of Human Midbrain Organoids for Modelling of the Dopaminergic System
[EMBO Journal] Scientists summarize recent advances and remaining challenges in developing such human midbrain organoids from hiPSCs.
Applied StemCell Launches hiEXâ„¢ Research iPSC Exosomes to Power Next-Generation Regenerative Medicine Research
[Applied StemCell] Applied StemCell announced the release of hiEXâ„¢ Research iPSC Exosomes, a new research-use-only product designed to enable scientists to explore the therapeutic potential of iPSC-derived exosomes in areas such as wound healing, aging, and nerve regeneration.
H3K79 Methylation and H3K36 Trimethylation Synergistically Regulate Gene Expression in Pluripotent Stem Cells
[Science Advances] Scientists revealed a functional synergism between H3K79 methylation and H3K36 trimethylation in regulating gene expression and cellular differentiation.
Differentiation of Human Induced Pluripotent Stem Cells Toward Implantable Chondroprogenitor Cells
[Cartilage] Investigators developed a protocol to direct iPSC through a mesenchymal stage into chondroprogenitors, resembling autologous chondroprogenitor cells used in autologous chondrocyte implantation.
Vesicle-Associated Membrane Protein 5 Is an Intrinsic Defense Factor for Embryonic Stem Cells Against Coronaviruses
[Nature Communications] Researchers identified vesicle-associated membrane protein 5 as a potent cell-autonomous defense factor against coronaviruses, including SARS-CoV-2, with high expression levels observed in ESCs and mesoderm.
Activation of Endogenous PRKN by Structural Derepression Is Linked to Increased Turnover of the E3 Ubiquitin Ligase
[Autophagy] The authors gene-edited neural progenitor cells and iPSCs to express PRKN-activating mutations in dopaminergic cultures.
Generation of Mature Epicardium Derived from Human-Induced Pluripotent Stem Cells via Inhibition of mTOR Signaling
[Nature Communications] Researchers introduced an optimized method that employs mammalian target of rapamycin (mTOR) signaling inhibition in embryonic epicardium, inducing a quiescent state that enhances multi-step epicardial maturation.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
