ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Maryland Stem Cell Research Fund Launches Stem Cell Therapy Manufacturing Grant Program

[MarylandInno] A program that supports young stem cell companies is launching a new funding opportunity to increase cell therapy manufacturing capacity in Maryland after seeing its state funding more than double.

PFOS Disrupts Key Developmental Pathways during hiPSC Derived Cardiomyocyte Differentiation In Vitro

[Toxicology in Vitro] Researchers examined the effect of perfluorooctanesulfonic acid (PFOS) on cardiomyocyte differentiation by transcriptomics profiling of two different hiPSC lines to see if they exhibited a common pattern of disruption.

Imprinting Fidelity in Mouse iPSCs Depends on Sex of Donor Cell and Medium Formulation

[Nature Communications] Scientists showed that imprinting defects were remarkably common in iPSCs, but their nature depended on the sex of donor cells and their response to culture conditions.

FACS-Assisted CRISPR-Cas9 Genome Editing of Human Induced Pluripotent Stem Cells

[STAR Protocols] The authors described the experimental strategy for generating knockout and knockin clonal populations of hiPSCs using single-cell sorting by flow cytometry.

CRISPR-Cas9 Screen in Human Embryonic Stem Cells to Identify Genes Required for Neural Differentiation

[STAR Protocols] Investigators presented a protocol to perform a CRISPR-Cas9 screen in hESCs to identify regulators that promoted SOX1 expression during neural progenitor cell formation.

Different Transcriptional Profiles of Human Embryonic Stem Cells Grown in a Feeder-Free Culture System and on Human Foreskin Fibroblast Feeder Layers

[Aging-Us] The authors revealed that the hESCs cultured in both conditions maintained the expression of stemness markers and the ability to spontaneously differentiate into the 3 germ layers.

Second-Generation HIV Integrase Inhibitors Induce Differentiation Dysregulation and Exert Toxic Effects in Human Embryonic Stem Cell and Mouse Models

[Journal of infectious Diseases] The effects of integrase inhibitors on two hESC lines were characterized with respect to markers of pluripotency, early differentiation, and cellular health.

Fast Generation of Forebrain Oligodendrocyte Spheroids from Human Embryonic Stem Cells by Transcription Factors

[iScience] Scientists presented evidence that overexpression of SOX10 and OLIG2 in hESCs derived ventral forebrain neural progenitors was sufficient to produce forebrain pre-oligodendrocytes (OLs) and mature OLs within 20-40 days.

METTLing in Stem Cell and Cancer Biology

[Stem Cell Reviews and Reports] Scientists summarize what is known about the role of methyltransferase-like (METTL) proteins in stem cell differentiation and their established roles in oncogenesis.

How to Fix Science’s Code Problem

[The Scientist] In the spring of 2013, around 180 scientists who had recently published computational studies in Science received an email from a Columbia University student asking for the code underpinning those pieces of research.

A Stem Cell Roadmap of Ribosome Heterogeneity Reveals a Function for RPL10A in Mesoderm Production

[Nature Communications] Employing quantitative mass spectrometry during hESC differentiation, investigators identified dozens of ribosome composition changes underlying cell fate specification.

Induction of Functional Xeno-Free MSCs from Human iPSCs via a Neural Crest Cell Lineage

[NPJ Regenerative Medicine] Researchers transplanted the xeno-free-induced MSCs into mouse models for bone and skeletal muscle regeneration and confirmed their regenerative potency.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.

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