ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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Greenstone Biosciences Awarded Breakthrough T1D Grant to Advance Islet Cell Platform

September 3, 2026

[Greenstone Biosciences (Business Wire)] Greenstone Biosciences has been awarded a Breakthrough T1D Industry Discovery and Development Partnership grant to develop a T1D-derived islet cell platform aimed at understanding and protecting insulin-producing β cells in people with type 1 diabetes.

Engineered Human iPSC-Derived Dendritic Cells Dressed with Tumor MHC Complexes As a Cancer Vaccine

August 26, 2026

[Cell Stem Cell] Investigators presented an approach that involves differentiating universal major histocompatibility complex (MHC)-deficient hiPSCs into CCR7⁺ migratory dendritic cells.

Modeling Sympathetic Neuro-Cardiac Interactions in a hiPSC-Based Microphysiological System

August 26, 2026

[Lab on a Chip] The authors presented a novel microphysiological system using a compartmentalized microfluidic device to integrate co-cultured hiPSC-derived cardiomyocytes and sympathetic neurons.

Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors

August 26, 2026

[Stem Cell Reports] The therapeutic potential of autologous-derived dendritic cells is challenged by the number and quality produced and the diversity of antigens presented. Researchers addressed this limitation by developing a protocol to generate induced pruriceptors from hiPSCs.

Single Cell CRISPR Screen Identifies Antagonism Between Nsd1-H3K36me2 and Ezh2-H3K27me3 Orchestrates Pluripotency Transition

August 26, 2026

[Stem Cell Reports] Scientists employed CRISPR/Cas9-based functional screening coupled with single-cell RNA-seq to investigate the epigenetic regulation governing the pluripotency network in mESCs.

Derivation of Human Post-Mitotic Cardiomyocytes from Tetraploid iPSCs

August 26, 2026

[Communications Biology] Researchers developed a strategy to establish human tetraploid iPSC (4N-iPSC) through cell fusion and found that iPSC-derived cardiomyocytes (iPS-CMs) derived from 4N-iPSCs were phenotypically similar to post-mitotic cardiomyocytes and were distinct from conventional iPS-CMs.

CRISPR/Cas9-Based Repair of a Heterozygous HNF1A Mutation in Patient-Derived hiPSCs

August 26, 2026

[Human Genetics] Investigators described an optimized CRISPR-based strategy for correcting a heterozygous HNF1A frameshift mutation in HNF1A-MODY patient-derived hiPSCs.

Stem Cell Therapies for Treatment of Diabetes Mellitus

August 26, 2026

[Chinese Medical Journal] Scientists summarize the recent advancements and molecular mechanisms of stem cells (SCs) in the treatment of diabetes mellitus (DM), underscoring the feasibility, benefits, and current limitations of SC therapy for DM, and offering a lucid perspective on their therapeutic possibilities.

Greenstone Biosciences Awarded Breakthrough T1D Grant to Advance Type 1 Diabetes-Derived Islet Cell Platform for Research and Development

August 26, 2026

[Breakthrough T1D] Greenstone Biosciences has been awarded a Breakthrough T1D Industry Discovery and Development Partnership (IDDP) grant to develop a T1D-derived islet cell platform aimed at understanding and protecting insulin-producing β cells in people with type 1 diabetes (T1D).

UBC Medicine Researchers Awarded More Than $39 Million in CIHR Funding

August 17, 2026

[The University of British Columbia] UBC Faculty of Medicine researchers have been awarded more than $39 million in federal funding through the Canadian Institutes of Health Research (CIHR) Project Grant: Spring 2026 competition.

Reversible Epiblast Regionalization Determines Differentiation Potential of Human Pluripotent Stem Cells

August 12, 2026

[Nature Biotechnology] Scientists explored variability in hPSC differentiation potential and the underlying epigenetic processes through the lens of epiblast anterior-posterior regionalization in vivo.

A Reproducible Three-Dimensional Model of Human Brain Tissue to Investigate Physiological and Disease-Associated Microglia Phenotypes

August 12, 2026

[Nature Neuroscience] Investigators developed a hiPSC-based three-dimensional cortical brain tissue model containing neurons, astrocytes, and microglia with high reproducibility, maturity and viability.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.