A Single Cell Characterisation of Human Embryogenesis Identifies Pluripotency Transitions and Putative Anterior Hypoblast Centre

Researchers characterized key events of human embryo morphogenesis, in the period between implantation and gastrulation, using single-cell analysis and functional studies.
[Nature Communications]
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INO80 Promotes H2A.Z Occupancy to Regulate Cell Fate Transition in Pluripotent Stem Cells

Scientists examined the impact of Ino80 deletion in naïve and primed PSCs. They found that Ino80 deletion had minimal effect on self-renewal and gene expression in the naïve state, but led to cellular differentiation and de-repression of developmental genes in the transition toward and maintenance of the primed state.
[Nucleic Acids Research]
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Arginine Methylation of METTL14 Promotes RNA N6-Methyladenosine Modification and Endoderm Differentiation of Mouse Embryonic Stem Cells

The authors investigated the role of methylation of the core methyltransferase METTL3/METTL14 in m6A regulation. They found that global mRNA m6A levels were greatly decreased in METTL14 R255K mutant mouse ESCs (mESCs) and that that loss of R255me preferentially affected endoderm differentiation in mESCs.
[Nature Communications]
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Genome Researchers Question Security Provisions in New US Senate Bill

Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science]
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Modeling Pancreatic Pathophysiology Using Genome Editing of Adult Stem Cell-Derived and Induced Pluripotent Stem Cell (iPSC)-Derived Organoids

Scientists provide highlights on the development of organoid technology, and the use of this culture system to study the pathophysiology of specific mutations in the development of pancreatic and gastric cancer.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Sekine, K., Ogawa, S., Tsuzuki, S., Kobayashi, T., Ikeda, K., Nakanishi, N., Takeuchi, K., Kanai, E., Otake, Y., Okamoto, S., Kobayashi, T., Takebe, T., & Taniguchi, H. (2020). Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media. Scientific Reports, 10(1), 17937. https://doi.org/10.1038/s41598-020-73908-1 Cite
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Two Vet Med Scholars Awarded Prestigious Canada Research Chairs

The Canadian federal government announced more than 150 new and renewed Canada Research Chairs (CRCs) at institutions across the country. Dr. Jack Chu’s successful CRC Tier II application focused on using stem cells to model human and animal developmental clocks and related disorders.
[University of Calgary]
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Five VP&S Teams Awarded Vagelos Precision Medicine Grants

The annual Vagelos Precision Medicine Pilot Grants have been awarded to five teams of VP&S researchers conducting innovative basic science, translational, and clinical research across multiple diseases, from novel cancer therapeutics to health disparities research.
[Columbia University Irving Medical Center]
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Enhanced Efficiency of Nonviral Direct Neuronal Reprogramming on Topographical Patterns

The authors used a polymer-BAM (Brn2, Ascl1, Myt1l) factor transfection polypex to reprogram primary mouse embryonic fibroblasts. Using a multiarchitecture chip, they screened for patterns that may improve transfection and/or subsequent induced neuron reprogramming efficiency.
[Biomaterials Science]
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Generation of Clinical-Grade Human Embryonic Stem Cell Line KthES11 according to Japanese Regulations

Cell line derivation, its propagation and storage of the human embryonic stem cell line, KthES11, were performed without feeders in an animal product-free environment according to current Good Manufacturing Practice standards.
[Stem Cell Research]
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Increased Maturation of iPSC-Derived Neurons in a Hydrogel-Based 3D Culture

Investigators cultured iPSC-derived excitatory neurons in 3D precast hydrogel plates and compared their maturation to 2D monolayer cultures.
[Journal of Neuroscience Methods]
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Generation of Patterned Kidney Organoids That Recapitulate the Adult Kidney Collecting Duct System from Expandable Ureteric Bud Progenitors

Researchers reported the generation of an expandable, 3D branching ureteric bud (UB) organoid culture model that could be derived from primary UB progenitors from mouse and human fetal kidneys, or generated de novo from human PSCs.
[Nature Communications]
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