ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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Genetic Variation Modulates Susceptibility to Aberrant DNA Hypomethylation and Imprint Deregulation in Naive Pluripotent Stem Cells

March 14, 2025

[Stem Cell Reports] Investigators showed that naive PSCs from inbred mouse strains exhibited strain-specific susceptibility to locus-specific deregulation of imprinting marks during reprogramming and upon exposure to a mitogen-activated protein kinase inhibitor, a common approach to maintain naive pluripotency.

Ground-State Pluripotent Stem Cells Are Characterized by Rac1-Dependent Cadherin-Enriched F-Actin Complexes Icon for the Forest of Biologists

March 14, 2025

[Journal of Cell Science] Scientists investigated how the actin cytoskeleton was regulated in different pluripotency states. They observed a drastic reorganization during the transition from ground-state naïve mESCs into converted prime epiblast stem cells.

CHCHD2 Rescues the Mitochondrial Dysfunction in iPSC-Derived Neurons from Patient with Mohr-Tranebjaerg Syndrome

March 13, 2025

[Cell Death & Disease] To investigate the molecular mechanisms underlying Mohr-Tranebjaerg syndrome (MTS), scientists established iPSCs from a male MTS patient carrying a novel translocase of inner mitochondrial membrane 8 mutation.

iPSCs Engrafted in Allogeneic Hosts without Immunosuppression Induce Donor-Specific Tolerance to Secondary Allografts

March 13, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Investigators found that iPSCs subcutaneously inoculated into MHC-compatible allogeneic host mice resisted rejection and formed teratomas without immunosuppressant administration.

Programming of Pluripotency and the Germ Line Co-Evolved from a Nanog Ancestor

March 10, 2025

[Cell Reports] Scientists discovered that Vent from the hemichordate Saccoglossus kowalevskii exhibited NANOG activity, programming pluripotency in Nanog−/− mouse pre-iPSCs and NANOG-depleted axolotl embryos.

PRC1 and PRC2 Proximal Interactome in Mouse Embryonic Stem Cells

March 10, 2025

[Cell Reports] To better understand Polycomb biology, scientists profiled the proximal interactome of multiple PRC1 and PRC2 subunits in mESCs. This analysis identified >100 proteins proximal to PRC1 and PRC2, including transcription factors and RNA-binding proteins.

Dux Cluster Duplication Ensures Full Activation of Totipotent Genes

March 6, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Scientists uncovered that the totipotency-related gene transcriptional profile was awakened to a much lesser extent in Dux mESCs compared to wild type mESCs following global DNA demethylation reprogramming or induction of DNA damage, mimicking the intrinsic events in preimplantation development

Circadian Rhythms in Stem Cells and Their Therapeutic Potential

March 5, 2025

[Stem Cell Research & Therapy] Understanding circadian rhythms in stem cells can optimize stem cell-based therapies by determining the best times for harvesting and administering stem cells, thereby enhancing therapeutic efficacy.

Totipotent-Like Reprogramming: Molecular Machineries and Chemical Manipulations

March 5, 2025

[Biochimica Et Biophysica Acta-Molecular Cell Research] Scientists summarize the current advancements in the molecular regulations of 2-cell-like cells and chemical manipulations of totipotent-like cells in mice, providing a foundation for understanding the regulatory networks underlying cell totipotency.

uBriGene Biosciences Submits Drug Master File for iPSC Reprogramming mRNA-LNP Kit

March 5, 2025

[uBriGene (BioSpace)] uBriGene Biosciences (uBriGene) announced the submission of its Drug Master File for its innovative iPSC Reprogramming mRNA-LNP Kit. This comprehensive regulatory submission details the manufacturing and characterizations of the iPSC Reprogramming mRNA-LNP Kit.

Pharmaceutical Inhibition of the Chk2 Kinase Mitigates Cone Photoreceptor Degeneration in an iPSC Model of Bardet-Biedl Syndrome

March 4, 2025

[iScience] In patient-derived iPSCs carrying BBS10 mutations, Bardet-Biedl syndrome retinal progenitor cells presented a DNA damage response that correlated with activation of the mitotic spindle checkpoint.

Scrambling Stem Cell Development: VMP1 and TMEM41B Regulate FZD2/FRIZZLED2 Secretion during Primitive Endoderm Specification

February 28, 2025

[Autophagy] Investigators generated Vmp1 and Tmem41b mutations in mESCs. While these mutations did not affect ESC self-renewal or pluripotency, they impaired differentiation into the primitive endoderm lineage.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.