Category Archives: ESC & iPSC

ESC & iPSC News is an online publication and email newsletter dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
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Since 2007, ESC & iPSC News has been providing weekly updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.

Induced Pluripotent Stem Cell-Derived Natural Killer Cells Gene-Modified to Express Chimeric Antigen Receptor-Targeting Solid Tumors

Scientists describe the characteristics of natural killer (NK) cells from multiple cell sources, including PSCs, the chimeric antigen receptor (CAR)-modification method and strategy for these NK cells.
[International Journal of Hematology]
Ueda, T., & Kaneko, S. (2020). Induced pluripotent stem cell-derived natural killer cells gene-modified to express chimeric antigen receptor-targeting solid tumors. International Journal of Hematology. https://doi.org/10.1007/s12185-020-02951-5 Cite
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Models of the Blood-Brain Barrier using iPSC-Derived Cells

The authors summarize important functions of the blood-brain barrier (BBB) and current efforts to create iPSC-derived BBB models in both static and dynamic conditions.
[Molecular and Cellular Neuroscience]
Delsing, L., Herland, A., Falk, A., Hicks, R., Synnergren, J., & Zetterberg, H. (2020). Models of the blood-brain barrier using iPSC-derived cells. Molecular and Cellular Neuroscience, 103533. https://doi.org/10.1016/j.mcn.2020.103533 Cite
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Dedifferentiation: Inspiration for Devising Engineering Strategies for Regenerative Medicine

Researchers compile the literature describing recent advances in research on dedifferentiation, with an emphasis on tissue-specific findings, cellular mechanisms, and potential therapeutic applications.
[NPJ Regenerative Medicine]
Yao, Y., & Wang, C. (2020). Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine. Npj Regenerative Medicine, 5(1), 1–11. https://doi.org/10.1038/s41536-020-00099-8 Cite
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Mapping Gene Circuits Essential for Germ Layer Differentiation via Loss-of-Function Screens in Haploid Human Embryonic Stem Cells

Scientists mapped the essential genes for the differentiation of human PSCs into the three germ layers by using a genome-wide loss-of-function library established in haploid human PSCs.
[Cell Stem Cell]
Yilmaz, A., Braverman-Gross, C., Bialer-Tsypin, A., Peretz, M., & Benvenisty, N. (2020). Mapping Gene Circuits Essential for Germ Layer Differentiation via Loss-of-Function Screens in Haploid Human Embryonic Stem Cells. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.06.023 Cite
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Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

By generating an ATF6 inducible patient-specific induced pluripotent stem cell line, researchers demonstrated that enhancing hepatic ER proteostasis preferentially reduced the secretion of amyloidogenic transthyretin.
[Stem Cell Reports]
Giadone, R. M., Liberti, D. C., Matte, T. M., Rosarda, J. D., Torres-Arancivia, C., Ghosh, S., Diedrich, J. K., Pankow, S., Skvir, N., Jean, J. C., Yates, J. R., Wilson, A. A., Connors, L. H., Kotton, D. N., Wiseman, R. L., & Murphy, G. J. (2020). Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.07.003 Cite
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Heart Regeneration using Pluripotent Stem Cells

In this review, the authors summarize the updated knowledge, perspectives, and limitations of PSC-derived cardiomyocytes for heart regeneration.
[Journal of Cardiology]
Kadota, S., Tanaka, Y., & Shiba, Y. (2020). Heart regeneration using pluripotent stem cells. Journal of Cardiology, 0(0). https://doi.org/10.1016/j.jjcc.2020.03.013 Cite
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Taming Human Brain Organoids One Cell at a Time

The authors summarize recent approaches, progresses and challenges in resolving brain organoid’s complexity through single-cell transcriptomics.
[Seminars in Cell & Developmental Biology]
Atamian, A., Cordón-Barris, L., & Quadrato, G. (2020). Taming human brain organoids one cell at a time. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2020.05.022 Cite
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Heart Regeneration Using Pluripotent Stem Cells

In this review, the authors summarize the updated knowledge, perspectives, and limitations of PSC-derived cardiomyocytes for heart regeneration.
[Journal of Cardiology]
Kadota, S., Tanaka, Y., & Shiba, Y. (2020). Heart regeneration using pluripotent stem cells. Journal of Cardiology, 0(0). https://doi.org/10.1016/j.jjcc.2020.03.013 Cite
Abstract

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Induced Pluripotent Stem Cell-Derived Natural Killer Cells Gene-Modified to Express Chimeric Antigen Receptor-Targeting Solid Tumors

Scientists describe the characteristics of natural killer (NK) cells from multiple cell sources, including PSCs, the chimeric antigen receptor (CAR)-modification method and strategy for these NK cells.
[International Journal of Hematology]
Ueda, T., & Kaneko, S. (2020). Induced pluripotent stem cell-derived natural killer cells gene-modified to express chimeric antigen receptor-targeting solid tumors. International Journal of Hematology. https://doi.org/10.1007/s12185-020-02951-5 Cite
Abstract

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Models of the Blood-Brain Barrier using iPSC-Derived Cells

The authors summarize important functions of the blood-brain barrier (BBB) and current efforts to create iPSC-derived BBB models in both static and dynamic conditions.
[Molecular and Cellular Neuroscience]
Delsing, L., Herland, A., Falk, A., Hicks, R., Synnergren, J., & Zetterberg, H. (2020). Models of the blood-brain barrier using iPSC-derived cells. Molecular and Cellular Neuroscience, 103533. https://doi.org/10.1016/j.mcn.2020.103533 Cite
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Developmental GABA Polarity Switch and Neuronal Plasticity in Bioengineered Neuronal Organoids

The authors report the directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
[Nature Communications]
Zafeiriou, M.-P., Bao, G., Hudson, J., Halder, R., Blenkle, A., Schreiber, M.-K., Fischer, A., Schild, D., & Zimmermann, W.-H. (2020). Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nature Communications, 11(1), 3791. https://doi.org/10.1038/s41467-020-17521-w Cite
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LIF Is Essential for ISC Function and Protects against Radiation-Induced Gastrointestinal Syndrome

Leukemia inhibitory factor (LIF) is a cytokine essential for maintaining pluripotency of mouse ESCs. Scientists found that LIF was present in the intestinal stem cell (ISC) niche in crypts and critical for the function of ISCs in maintaining the intestinal epithelial homeostasis and regeneration.
[Cell Death & Disease]
Wang, H., Wang, J., Zhao, Y., Zhang, X., Liu, J., Zhang, C., Haffty, B., Verzi, M., Zhang, L., Gao, N., Feng, Z., & Hu, W. (2020). LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death & Disease, 11(7), 1–15. https://doi.org/10.1038/s41419-020-02790-6 Cite
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