ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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Tunable Differentiation of Human CD4+ and CD8+ T Cells from Pluripotent Stem Cells

January 14, 2026

[Cell Stem Cell] Using feeder- and serum-free conditions, the authors found that CD4⁺ vs CD8⁺ T cell commitment from PSCs can be controlled by fine-tuning the dynamics of Notch and T cell receptor signaling delivered to CD4⁺CD8⁺ double-positive T cells.

Generation of Thymus-Reconstituting T Cell Progenitors from Human Pluripotent Stem Cells

January 14, 2026

[Cell Reports Methods] The authors described the engineering of T cell progenitors capable of direct and long-term reconstitution of the thymus. In the thymus, hPSC-derived progenitor T cells developed into single-positive human T cells that entered circulation and settled in the spleen.

Landscape of microRNA and Target Expression Variation and Covariation in Single Mouse Embryonic Stem Cells

January 14, 2026

[Genome Research] Investigators systematically studied microRNA alternative functions in mESCs by genetically deleting Drosha, leading to global loss of microRNAs.

Predicting Metabolic Dysfunction-Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells

January 14, 2026

[Stem Cells Translational Medicine] Researchers developed an iPSC-based metabolic dysfunction–associated steatotic liver disease risk predictor using functional lipid accumulation assessments.

Necessity of Notch3 Signaling in Myofiber Maturation in a Pluripotent Stem Cell Transplant Model

January 14, 2026

[Skeletal Muscle] Since a role for Notch3 in skeletal muscle maturation is unknown, the authors investigated whether Notch3 is required for this in vivo molecular maturation switch.

Knockdown of Histone H2A Deubiquitinase BAP1 in Human Embryonic Stem Cells Restricts Their Differentiation Repertoire but Is Dispensable for Maintaining Their Undifferentiated State

January 14, 2026

[Biochemical and Biophysical Research Communications] Scientists generated hESCs that stably express doxycycline inducible BAP1 shRNAs. In the undifferentiated cells, doxycycline addition induced BAP1 downregulation, without any effect on the undifferentiated state.

Progress in Stem Cell-Based Embryo Models and Their Applications in Developmental Biology and Biomedicine

January 14, 2026

[Nature Reviews Molecular Cell Biology] The authors discuss recent advances in the development of human stem cell-based embryo models and key challenges in their construction and applications.

Modeling Mammalian Meiosis with Pluripotent Stem Cells: Progress and Challenges

January 14, 2026

[Clinical Epigenetics] Scientists outline the molecular regulation of meiosis in mammals and discuss the way in which the use of PSC-based models has begun to supplement classical methodologies in the study of meiosis.

One Genomics and CiRA Foundation Announce Strategic Research Collaboration to Advance Precision Genome Engineering

January 14, 2026

[One Genomics (Business Wire)] One Genomics announced a strategic research collaboration agreement with the CiRA Foundation to advance precision genome engineering technologies.

Generation and Validation of an Aryl Hydrocarbon Receptor Knockout Human Embryonic Stem Cell Line

January 8, 2026

[Endocrinology] To characterize the aryl hydrocarbon receptor pathway in developing human β-cells, scientists differentiated hESCs into “islet-like” cell clusters in vitro and treated cells with vehicle or dioxin for 24-hours at key stages of differentiation.

ERK Phosphorylates HNRNPF to Promote the Proliferation and Suppress the Differentiation of Embryonic Stem Cells

January 8, 2026

[Nucleic Acids Research] Scientists demonstrated that extracellular signal-regulated kinase (ERK) 2 phosphorylates heterogenous nuclear ribonucleoprotein F (HNRNPF) on Ser346 and Tyr356. Hnrnpf knockout reduces ESC proliferation rate and promotes ESC differentiation.

Exiting the Ground State: The Broad Spectrum of Cell Fates Accessible from NaïVe Human Pluripotent Stem Cells

January 8, 2026

[Cellular and Molecular Life Sciences] Investigators discuss the broad spectrum of cell fates accessible from naïve hPSCs and the signaling pathways that guide the exit from the ground state of human pluripotency.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.