ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Network Analysis of Transcriptomic Data Uncovers Molecular Signatures and the Interplay of mRNAs, lncRNAs, and miRNAs in Human Embryonic Stem Cells

[Differentiation] Researchers used weighted gene co-expression network analysis (WGCNA) on transcriptomic data retrieved from RNA-seq and small RNA-seq experiments and reconstructed the core human pluripotency network consisting of 375 mRNA, 57 lncRNA and 207 miRNAs.

Generation of Induced Pluripotent Stem Cell Line (RCMGi012-a) From Fibroblasts of Patient With Mucopolysaccharidosis Type VI

[Stem Cell Research] Skin fibroblasts obtained from a five-year-old girl with genetically proven and clinically manifested mucopolysaccharidosis type VI were successfully transformed into induced pluripotent stem cells by using Sendai virus-based reprogramming vectors including the four Yamanaka factors namely SOX2, OCT3/4, KLF4, and c-MYC.

Functional Engineering of Human iPSC-Derived Parasympathetic Neurons Enhances Responsiveness to Gastrointestinal Hormones

[FEBS Open Bio] Researchers focused on the receptors of five gastrointestinal hormones, and established human iPSC lines that functionally expressed each receptor.

Use of 2D Minilungs from Human Embryonic Stem Cells to Study the Interaction of Cryptococcus neoformans with the Respiratory Tract

[Microbes And Infection] The authors used 2D human lung organoid derived from hESCs, to investigate Cryptococcus neoformans-host interactions. C. neoformans is an opportunistic fungus acquired by inhalation that causes systemic mycosis mainly in immunocompromised individuals.

BRG1 Enhances Porcine iPSC Pluripotency Through WNT/β-Catenin and Autophagy Pathways

[Theriogenology] The mechanism was investigated by regulating the WNT/β-catenin signaling pathway and autophagy flux. The results showed that inhibition of BRG1 decreased pluripotency-related gene expression in porcine iPSCs

Application of Patient-Derived Induced Pluripotent Stem Cells and Organoids in Inherited Retinal Diseases

[Current Stem Cell Research & Therapy] Investigators focuse on the status of patient-derived iPSCs and organoids in inherited retinal diseases in recent years concerning disease modeling and therapeutic exploration, along with potential challenges for translating laboratory research to clinical application.

IICD Faculty Members Named 2023 Allen Distinguished Investigators

[Columbia University] Two IICD faculty members, Elham Azizi - Herbert and Florence Irving Assistant Professor of Cancer Data Research and Assistant Professor of Biomedical Engineering - and José McFaline-Figueroa - Assistant Professor of Biomedical Engineering -, are among the 18 new Allen Distinguished Investigators.

Developmental Potency of Human ES Cell-Derived Mesenchymal Stem Cells Revealed in Mouse Embryos Following Blastocyst Injection

[Cell Reports] Scientists injected GFP-tagged human ESC-derived MSCs (EMSCs) into mouse blastocysts. EMSCs survived well and penetrated both the inner cell mass and trophectoderm, correlating to the higher anti-apoptotic capability of EMSCs than hESCs.

Microarray Analysis of lncRNAs and mRNAs in Spinal Cord Contusion Rats with iPSC-Derived A2B5+ Oligodendrocyte Precursor Cells Transplantation

[Heliyon] Induced pluripotent stem cell (iPSC)-derived A2B5+ oligodendrocyte precursor cells were obtained from mouse embryonic fibroblasts and injected into the lesion sites of spinal cord contusion rats.

Immune-Privileged Tissues Formed from Immunologically Cloaked Mouse Embryonic Stem Cells Survive Long Term in Allogeneic Hosts

[Nature Biomedical Engineering] Investigators showed that the overexpression of eight immunomodulatory transgenes in mouse ESCs was sufficient to immunologically ‘cloak’ the cells as well as tissues derived from them, allowing their survival for months in outbred and allogeneic inbred recipients.

Integration of Xeno-Free Single-Cell Cloning in CRISPR-Mediated DNA Editing of Human iPSCs Improves Homogeneity and Methodological Efficiency of Cellular Disease Modeling

[Stem Cell Reports] The authors provided a xeno-free method for single-cell cloning of CRISPRed iPSCs achieving a clonal survival of up to 70% within seven–ten days.

BACH1 Regulates the Differentiation of Vascular Smooth Muscle Cells from Human Embryonic Stem Cells via CARM1-Mediated Methylation of H3R17

[Cell Reports] Scientists foundnd that the loss of BACH1 in human embryonic stem cells (hESCs) attenuated the expression of vascular smooth muscle cell (VSMC) marker genes, whereas overexpression of BACH1 after mesoderm induction increased the expression of VSMC markers during in vitro hESC-VSMC differentiation.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.