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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Histone Methyltransferases MLL2 and SETD1A/B Play Distinct Roles in H3K4me3 Deposition During the Transition from Totipotency to Pluripotency
[EMBO Journal] The authors revealed that the histone methyltransferase MLL2 was responsible for installing histone H3 lysine 4 trimethylation (H3K4me3) in totipotent embryos, while a transition to SETD1A/B-deposited H3K4me3 occured in pluripotent embryos.
Axol Bioscience Secures SMART Grant to Accelerate the Development of a Commercial iPSC Powered ALS Models
[Axol Bioscience] Axol Bioscience has been awarded a SMART Grant by Scottish Enterprise to Accelerate ALS Research through the development of ALS-related phenotypes using human iPSCs. This represents another significant step towards better disease modelling and ALS drug discovery.
The Complete Telomere-to-Telomere Sequence of a Mouse Genome
[Science] Researchers sequenced and assembled the telomere-to-telomere genome of mouse haploid embryonic stem cells. The results revealed more than 7.7% of previously uncovered sequences of the mouse genome, including ribosomal DNA arrays and pericentromeric and subtelomeric regions.
BRAFV600E Induces Key Features of LCH in iPSCs with Cell Type-Specific Phenotypes and Drug Responses
[Blood] Scientists generated a human in vitro model for Langerhans cell histiocytosis (LCH) using induced pluripotent stem cells (iPSCs) harboring the BRAFV600E mutation, the most common genetic driver of LCH.
Genetic and Environmental Risks for Clonal Hematopoiesis and Cancer
[Journal of Experimental Medicine] The authors explore the genetic and environmental factors that predispose individuals to clonal hematopoiesis (CH) with unique variant signatures and discuss how CH drives cancer progression.
Trends and Challenges in Organoid Modeling and Expansion with Pluripotent Stem Cells and Somatic Tissue
[PeerJ] To bridge the gaps between basic research and pharmaceutical as well as clinical applications, efforts have been made to develop organoids from tissue-derived stem cells or pluripotent stem cells. The authors summarize the status of organoid development and applications and highlight recent progress and limitations.
Highly Efficient Generation of Mature Megakaryocytes and Functional Platelets from Human Embryonic Stem Cells
[Stem Cell Research & Therapy] Researchers presented a novel approach to highly and efficiently generate mature megakaryocytes and functional platelets from human ESCs (hESCs). The in vivo functionality of hESC-derived platelets closely resembled that of natural human platelets.
Embryoid Body-Based Differentiation of Human-Induced Pluripotent Stem Cells into Cells with a Corneal Stromal Keratocyte Phenotype
[BMJ Open] Researchers established an innovative and effective method to generate corneal stromal keratocytes via the embryoid body-based differentiation of human iPSCs, which may be employed for cell-based therapy of corneal stromal opacities.
DEAD-Box RNA Helicase 10 Is Required for 18S rRNA Maturation by Controlling the Release of U3 snoRNA from Pre-rRNA in Embryonic Stem Cells
[Nature Communications] The authors discovered that DEAD-box RNA helicase 10 (DDX10) was indispensable for upholding cellular homeostasis and the viability of mouse ESCs. DDX10 participated in the process of liquid-liquid phase separation, which was necessary for efficient ribosome biogenesis.
Alloy Therapeutics Signs Collaboration and License Agreement with Takeda to Develop Cell Therapy Platform
[Alloy Therapeutics, Inc.] Alloy Therapeutics, Inc. announced a strategic collaboration and license agreement with Takeda Pharmaceutical Company Limited to develop Takeda’s proprietary iPSC derived CAR-T cell platform and iPSC-derived CAR-NK platform.
Phosphorylation-Mediated Disassembly of C-Terminal Binding Protein 2 Tetramer Impedes Epigenetic Silencing of Pluripotency in Mouse Embryonic Stem Cells
[Nucleic Acids Research] Researchers elucidated that DNA damage activated Chk2, leading to the phosphorylation of serine 164 on C-terminal binding protein 2 (Ctbp2).
Inhibition of Lung Tumorigenesis by Transient Reprogramming in Cancer Cells
[Cell Death & Disease] Investigators found that Oct4, Sox2, Klf4, and c-Myc expression limited the growth of transformed lung cells by inducing apoptosis and senescence. They identify Oct4 and Klf4 as the main individual reprogramming factors responsible for this effect.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
