ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

TreeFrog Therapeutics Launches a $100,000 Research Grant in Regenerative Medicine

[TreeFrog Therapeutics] TreeFrog Therapeutics announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell biology and regenerative medicine.

Jiang Lab Received a $45000 Gift Check from HIST1H1E (H1-E) Syndrome Foundation

[Yale School of Medicine] the family of Kimberly Greenberg and HIST1H1ESyndrome Foundation presented a $45,000 gift check to Dr. Jiang’s lab, which has succeeded on modeling H1-4 causing neurodevelopmental defects using human H1-4 patient derived iPSC and brain organoi.

URMC Partners with Sana Biotechnology to Advance Cell-based Therapies in Neurological Disorders

[The University of Rochester Medical Center] The University of Rochester Medical Center (URMC) and Sana Biotechnology have entered into an agreement which will allow Sana to expand its manufacturing footprint and create new job opportunities in Rochester.

Hbxip Is Essential for Murine Embryogenesis and Regulates Embryonic Stem Cell Differentiation through Activating mTORC1

[Development] The authors demonstrated that homozygous knockout of Hbxip led to embryonic lethality, with retarded growth around E7.5, and that depletion of Hbxip compromised the self-renewal of ESCs.

Highly Sensitive and Non-disruptive Detection of Residual Undifferentiated Cells by Measuring miRNAs in Culture Supernatant

[Scientific Reports] Scientists tested a highly sensitive and non-disruptive quality-testing method that involves measuring miRNAs in culture supernatants released by cells.

NANOG Initiates Epiblast Fate through the Coordination of Pluripotency Genes Expression

[Nature Communications] Scientists showed that the coordinated expression of pluripotency markers defined epiblast identity. Conversely, ICM progenitor cells displayed random cell-to-cell variability in expression of various pluripotency markers.

Satellite Repeat Transcripts Modulate Heterochromatin Condensates and Safeguard Chromosome Stability in Mouse Embryonic Stem Cells

[Nature Communications] Researchers reported that major satellite repeats transcripts could drive the formation of HP1ɑ droplets in vitro, and modulated heterochromatin into dynamic condensates in ESCs, contributing to the formation of large nuclear domains that were characteristic of pluripotent cells.

BABY BOOM Regulates Early Embryo and Endosperm Development

[Proceedings of the National Academy of Sciences of the United States of America] Investigators reexamined BABY BOOM expression and function in the model plant Arabidopsis thaliana using reporter analysis and newly developed CRISPR mutants.

Exosomes from Human Induced Pluripotent Stem Cells-Derived Keratinocytes Accelerate Burn Wound Healing through miR-762 Mediated Promotion of Keratinocytes and Endothelial Cells Migration

[Journal of Nanobiotechnology] The authors explored the effects of exosomes produced by iPSCs-derived keratinocytes in a model of deep second-degree burn wound healing and evaluated the mechanistic basis for the observed activity.

Delamination of Trophoblast-Like Syncytia from the Amniotic Ectodermal Analogue in Human Primed Embryonic Stem Cell-Based Differentiation Model

[Cell Reports] Investigators reported that chemical blockage of ACTIVIN/NODAL and FGF signals was sufficient to steer human primed ESCs into GATA3-expressing cells that gave rise to placental hormone-producing syncytia.

Generating Human Artery and Vein Cells from Pluripotent Stem Cells Highlights the Arterial Tropism of Nipah and Hendra Viruses

[Cell] Researchers generated >90% pure human artery or vein endothelial cells from pluripotent stem cells within 3–4 days abd specified artery cells by inhibiting vein-specifying signals and vice versa.

Uncoupling of Proliferative Capacity from Developmental Stage during Directed Cardiac Differentiation of Pluripotent Stem Cells

[Stem Cells and Development] Using standard CDM3 differentiation protocols, gene expression profiles demonstrated that hiPSC-derived cardiomyocytes did not progress past the equivalent of embryonic day 14.5 of murine cardiac development.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.

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