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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
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hPSC Models in Cancer Mechanisms and Therapeutic Discovery
[Trends in Molecular Medicine] The authors synthesize emerging findings from hPSC models, define key technological and biological gaps, and outline future directions for integrating hPSC-based modeling into precision oncology and translational cancer research.
Benzo[a]Pyrene-Induced AHR Activation in Human ESCs Primes Premature Neurogenesis in Cerebral Organoids
[Journal of Hazardous Materials] Scientists characterized aryl hydrocarbon receptor (AHR) expression during hESC-derived cerebral organoid development and observed the highest expression at the ESC stage, followed by a decline during subsequent differentiation.
Highly Efficient Base Editing at PCSK9 and Normal Human Embryo Development
[Nature] Investigators evaluated DNA repair outcomes at nicks and mismatches introduced by base editors at the PCSK9 and HBG loci in human embryos.
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
[Advanced Science] Researchers generated human cellular models by introducing patient-specific OCRL mutations into healthy iPSCs using base editors and prime editors, followed by differentiation into human trabecular meshwork-like cells.
Development-Inspired Approach for the Derivation of Functional and Transplantable Salivary Gland Organoids from Human Pluripotent Stem Cells
[Nature Communications] Scientists developed a developmentally inspired strategy to derive salivary gland epithelial progenitor (SGEP) cells from hPSCs.
Generation of Eight-Cell Embryo-Like Cells from Human Pluripotent Stem Cells
[Nature Protocols] Scientists provide a detailed protocol for inducing, isolating and characterizing eight-cell embryo-like cells generated a novel medium.
Kincell Bio and Cellipont Bioservices Merge to Form Kincellis Advanced Therapies
[Kincell Bio] Kincell Bio and Cellipont Bioservices announced the completion of their merger to form Kincellis Advanced Therapies (Kincellis), a US-based contract development and manufacturing organization focused on cell therapies and other advanced modalities.
Two Parallel Neural Ectoderm Progenitors Contribute to the Developing Brain
[Nature Neuroscience] Does a common neural ectoderm progenitor generate the entire brain? Or do multiple neural ectoderm progenitors exist, each restricted to form specific brain regions? Lineage tracing studies of mouse embryos support the latter model.
Self-Amplifying RNA Enables Rapid, Durable, Integration-Free Programming of hiPSCs
[Cell Reports Methods] Investigators used self-amplifying RNA (saRNA) to deliver transcription factors and functional reporters in hiPSCs and demonstrated that protein expression can persist for weeks. They showed that a single transfection of saRNA-encoded jRCaMP1b in hiPSCs generates sustained reporter expression throughout differentiation to 3D cardiac spheroids.
Harvard, Yale Researchers Awarded $46 Million Grant To Study Autism, Brain Development
[Harvard Medical School] A $46 million grant from a new autism research initiative, Aligning Research to Impact Autism, is turbocharging efforts at Harvard and Yale to understand human brain development and provide insight into the roots of profound autism.
Site-Specific Programming Characterizes Dynamic Post-Translational Acetylation of Histone H2B Lysine 108 in Mouse Embryonic Stem Cells
[Nature Communications] Researchers established a genetic code expansion-based platform in mESCs for site-specific proteomic mapping and functional analysis within native chromatin. Using this platform, they revealed Rps19bp1 promotes Sirt1-mediated deacetylation of histone H2B lysine 108 acetylation.
Induced Pluripotent Stem Cells from Discovery to Translation
[Nature Medicine] The authors evaluate the technological and translational trajectories that have defined the iPSC era and analyzes the operational barriers to therapeutic development.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
