ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Developmental Modeling of Hepatogenesis Using Obese iPSCs-Hepatocyte Differentiation Uncovers Pathological Features

[Cell Death & Disease] Scientists used hiPSCs generated from normal and genetically obese subjects and differentiated them into hepatocytes in cell culture. They showed that hepatocytes from obese iPSCs stored more lipids and showed increased cell death than normal iPSCs.

Regional and Developmental Characteristics of Human Embryo Mosaicism Revealed by Single Cell Sequencing

[PLoS Genetics] The authors estimated the genetic concordance between trophectoderm, inner cell mass, and the corresponding hESCs, and explored the characteristics of mosaicism in human blastocyst and hESCs on a single cell level.

PCGF6 Controls Neuroectoderm Specification of Human Pluripotent Stem Cells by Activating SOX2 Expression

[Nature Communications] Investigators reported that PCGF6 controled neuroectoderm specification of hPSCs by activating the SOX2 gene.

Generation and Characterization of Cynomolgus Monkey Kidney Fibroblasts (cmKF)-Derived Induced Pluripotent Stem Cells (cmKF-iPS-C5)

[Stem Cell Research] The authors reprogrammed cynomolgus monkey kidney fibroblasts as a control for animal iPSCs and to study autologous transplant.

Size-Adjustable Self-Assembled Nanoparticles through Microfluidic Platform Promotes Neuronal Differentiation of Mouse Embryonic Stem Cells

[Biomaterials Advances] Amphiphilic chitosan oligosaccharide-cholesterol copolymers were synthesized by varying cholesterol content and self-assembled into spherical micelle in a microfluidic chip with different flow rates.

Chromosome Silencing In Vitro Reveals Trisomy 21 Causes Cell-Autonomous Deficits in Angiogenesis and Early Dysregulation in Notch Signaling

[Cell Reports] To understand which cell types and pathways are more directly affected by trisomy 21 (T21), the authors used an inducible-XIST system to silence one chromosome 21 in vitro. T21 caused the dysregulation of Notch signaling in iPSCs, potentially affecting cell-type programming.

Mettl14-Driven Senescence-Associated Secretory Phenotype Facilitates Somatic Cell Reprogramming

[Stem Cell Reports] Scientists demonstrated that Mettl14, another component of the methyltransferase complex, could significantly enhance the generation of iPSCs in an m6A-independent manner.

The Emergence of the Stem Cell Niche

[Trends in Cell Biology] The authors describe new applications for generating emerging niches from hPSCs using developmental principles and highlight potential applications for regeneration and therapeutics.

Induced Pluripotent Stem Cell-Derived Corneal Cells: Current Status and Application

[Stem Cell Reviews and Reports] Investigators discuss the early development of the cornea because protocols differentiating iPSCs toward corneal lineages rely heavily upon recapitulating this development.

State ‘Personhood’ Laws Threaten Embryonic Stem Cell Research

[Bloomberg Law] Biomedical scientists using embryonic stem cells or fetal tissue could find their studies at risk in conservative states aiming to redefine personhood after the US Supreme Court’s rollback of abortion rights.

Prominent Stanford University Scientist and Cellular Reprogramming Innovator Will Oversee All Research for Turn Bio Français

[Turn Biotechnologies (Cision US, Inc.)] Turn Biotechnologies, a cell rejuvenation company developing novel mRNA medicines to cure untreatable, age-related conditions, announced that Co-Founder Dr. Vittorio Sebastiano will become its head of research.

Stem Cell-Based Therapy for Human Diseases

[Signal Transduction and Targeted Therapy] Scientists provide an update on recent clinical applications using either human pluripotent stem cells or mesenchymal stem cells derived from bone marrow, adipose tissue, or the umbilical cord for the treatment of human diseases.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.

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