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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Identifying SETBP1 Haploinsufficiency Molecular Pathways to Improve Patient Diagnosis Using Induced Pluripotent Stem Cells and Neural Disease Modelling
[Molecular Autism] Genetic variants were introduced into iPSCs and subsequently differentiated into neurons to model the disease. Scientists measured changes in cellular differentiation, SETBP1 protein localisation, and gene expression changes.
SALL2 Regulates Neural Differentiation of Mouse Embryonic Stem Cells through Tuba1a
[Cell Death & Disease] With the establishment of Sall2 deficient mouse ESCs, the in vitro neural differentiation system was leveraged to interrogate the function of SALL2, which showed impaired neural differentiation of Sall2 knockout ESCs.
A Suboptimal OCT4-SOX2 Binding Site Facilitates the Naïve-State Specific Function of a Klf4 Enhancer
[PLOS One] Using a combination of biochemical tests, reporter assays, and endogenous mutations in mouse embryonic stem cells, researchers have studied the binding sites for the transcription factors OCT4 and SOX2.
Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation
[Journal of Biological Chemistry] Investigators introduced a homozygous loss-of-function point mutation in mixed lineage leukemia-1 (MLL1) within hiPSCs. This mutation mimics the histone methylation, gene expression, and epithelial-mesenchymal transition phenotypes of MLL1F-LSCs- without requiring a translocation or functional wild-type MLL1.
Generation of ID1/3 Knockout Human Embryonic Stem Cell Lines (WAe009-a-2A and WAe009-a-2B) Derived from H9 Using CRISPR/Cas9
[Stem Cell Research] Scientists created two ID1/3 knockout cell lines from a human ESC line by CRISPR/Cas9-mediated gene targeting.
Recapitulation of NOD/RIPK2 Signaling in iPSC-Derived Macrophages
[Slas Discovery] Through optimization of an iPSC-derived macrophage (IDMs) differentiation protocol, a six-fold increase in the production yield of myeloid progenitors was achieved. The derived IDMs were further characterized with respect to nucleotide-binding oligomerization domain (NOD) and receptor-interacting serine/threonine-protein kinase 2 (RIPK2) signaling, a key regulatory pathway for autoimmune diseases.
Generation of an Induced Pluripotent Stem Cell Line from a Type 1 Neurofibromatosis Patient with NF1 Mutation
[Stem Cell Research] A human iPSC line was generated from patients with type 1 neurofibromatosis (NF-1), carrying a heterozygous mutation in the NF1 gene. Peripheral blood mononuclear cells were reprogrammed using non-integrating delivery of KFL4, OCT4, SOX2, BCL-XL, and c-MYC.
GC Therapeutics Secures $65M to Launch into Off-the-Shelf iPSC Therapy Space
[GC Therapeutics (Pharmaceutical Technology)] GC Therapeutics has propelled itself into the cell therapy space with $65m under its belt to deliver off-the-shelf iPSC-based medicines.
NOTUM-Mediated WNT Silencing Drives Extravillous Trophoblast Cell Lineage Development
The authors showed that aberrant WNT signaling undermines extravillous trophoblast (EVT) cell differentiation. Notum, palmitoleoyl-protein carboxylesterase (NOTUM), a negative regulator of canonical WNT signaling,...
Induced Pluripotent Stem Cell-Derived Macrophages as a Platform for Modelling Human Disease
The ability to generate macrophages from induced pluripotent stem (iPS) cells has revolutionized macrophage biology, with the generation of iPS cell-derived macrophages (iMacs) providing...
ZFP64 Drives Glycolysis-Mediated Stem Cell-Like Properties and Tumorigenesis in Breast Cancer
[Biology Direct] Researchers investigated whether ZFP64 regulated stem cell-like properties and tumorigenesis in breast cancer by the glycolytic pathway.
m6A mRNA Methylation by METTL14 Regulates Early Pancreatic Cell Differentiation
[EMBO Journal] Investigators showed that the N6-methyladenosine (m6A) landscape was dynamic during human pancreas development, and that METTL14, one of the m6A writer complex proteins, is essential for the early differentiation of both human and mouse pancreatic cells.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
