ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Chromosome Territory Reorganization through Artificial Chromosome Fusion Is Compatible with Cell Fate Determination and Mouse Development

[Cell Discovery] Researchers fused chromosome 15 and 17 in mouse haploid ESCs (haESCs), resulting in distinct changes of territories in the cognate chromosomes, but with little effect on gene expression, pluripotency, and gamete functions of haESCs.

Binary Colloidal Crystals Promote Cardiac Differentiation of Human Pluripotent Stem Cells via Nuclear Accumulation of SETDB1

[ACS Nano] Cell nucleus, cytoskeleton, and epigenetic states of hiPSCs on the 5PM binary colloidal crystals were analyzed using atomic force microscopy, molecular biology assays, and the assay for transposase-accessible chromatin sequencing.

Epithelial Disruption Drives Mesendoderm Differentiation in Human Pluripotent Stem Cells by Enabling TGF-β Protein Sensing

[Nature Communications] Scientists interrogated the interplay between tissue organization and morphogens by using hiPSCs downregulated for the morphogen regulator GLYPICAN-4, in which defects in tight junctions resulted in areas of disrupted epithelial integrity.

RSL24D1 Sustains Steady-State Ribosome Biogenesis and Pluripotency Translational Programs in Embryonic Stem Cells

[Nature Communications] Researchers identified RSL24D1 as highly expressed in both mouse and human PSCs. RSL24D1 was associated with nuclear pre-ribosomes and was required for the biogenesis of 60S subunits in mESCs.

Efficient Generation of ETX Embryoids That Recapitulate the Entire Window of Murine Egg Cylinder Development

[Science Advances] Investigators provided an optimized method for reliable and efficient generation of embryonic–trophoblast–extra-embryonic endoderm (ETX) embryoids that developed into late gastrulation in static culture conditions.

Lnc956 Regulates Mouse Embryonic Stem Cell Differentiation in Response to DNA Damage in a p53-Independent Pathway

[Science Advances] The authors identified a p53-independent quality control factor lncRNA NONMMUT028956 (Lnc956) in mouse ESCs. Lnc956 was prevalently expressed in ESCs and regulated the differentiation of ESCs after DNA damage.

Glycolytic Pfkp Acts as a Lin41 Protein Kinase to Promote Endodermal Differentiation of Embryonic Stem Cells

[EMBO Reports] Scientists established an intersection between LIF-Stat3 signaling that was essential for maintaining mESC pluripotency, and the glycolytic enzyme, the platelet isoform of phosphofructokinase (Pfkp).

Ribosomal Proteins Regulate 2-Cell-Stage Transcriptome in Mouse Embryonic Stem Cells

[Stem Cell Reports] Investigators reported that the ribosomal proteins RPL14, RPL18, and RPL23 maintained the identity of mESCs and regulated the expression of 2-cell-stage-specific transcripts.

Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down Syndrome

[Stem Cell Reviews and Reports] Researchers generated iPSCs from individuals with Down syndrome and euploid controls using urine-derived cells and examined their ability to differentiate into neurons and astrocytes grown in monolayer cultures, as well as into 3D cerebral organoids.

Hypoimmunogenic Human Pluripotent Stem Cells Are Valid Cell Sources for Cell Therapeutics with Normal Self-Renewal and Multilineage Differentiation Capacity

[Stem Cell Research & Therapy] Scientists systematically studied the self-renewal and differentiation potency of three types of hypoimmunogenic hPSCs: B2Mnull, B2MmHLAG, and B2Mm/sHLAG.

VGLL4-TEAD1 Promotes Vascular Smooth Muscle Cell Differentiation from Human Pluripotent Stem Cells via TET2

[Journal of Molecular and Cellular Cardiology] Using microarray profiling, investigators found that the Hippo pathway components vestigial-like family member 4 (VGLL4) and TEA domain transcription factor 1 (TEAD1) were upregulated during vascular smooth muscle cell differentiation from H1 ESCs.

Administration of Stem Cells against Cardiovascular Diseases with a Focus on Molecular Mechanisms: Current Knowledge and Prospects

[Tissue and Cell] The authors explain the application of stem cells, especially iPSCs and mesenchymal stem cells, in the treatment of cardiovascular diseases with a focus on cellular and molecular mechanisms and then discuss the advantages, disadvantages, and perspectives of using this technology in the treatment of these diseases.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.

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