Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
Induced hepatocyte-like (iHep) cells were generated from induced pluripotent stem cells integrated with the albumin reporter gene. The therapeutic properties of these iHep cells were investigated after transplantation in fibrotic liver tissues of a mouse model.
[Stem Cell Research & Therapy]
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Investigators describe a medulloblastoma model using induced pluripotent stem cell-derived human neuroepithelial stem cells generated from a Gorlin syndrome patient carrying a germline mutation in the sonic hedgehogreceptor PTCH1.
[Proceedings of the National Academy of Sciences of the United States of America]
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Susanto, E., Navarro, A. M., Zhou, L., Sundström, A., Bree, N. van, Stantic, M., Moslem, M., Tailor, J., Rietdijk, J., Zubillaga, V., Hübner, J.-M., Weishaupt, H., Wolfsberger, J., Alafuzoff, I., Nordgren, A., Magnaldo, T., Siesjö, P., Johnsen, J. I., Kool, M., … Wilhelm, M. (2020). Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1920521117 Cite
To gain new insights into aberrant Down Syndrome (DS) development during early stages of mesoderm formation and its possible connection to lower solid tumor prevalence, the authors developed the first model of two types of DS iPSC-derived stromal cells.
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Galat, Y., Perepitchka, M., Elcheva, I., Iannaccone, S., Iannaccone, P. M., & Galat, V. (2020). iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome. Scientific Reports, 10(1), 13252. https://doi.org/10.1038/s41598-020-69418-9 Cite
Investigators showed that the protein kinase D inhibitor CID755673 was able to maintain the undifferentiated state of mouse ESCs in combination with the mitogen-activated protein kinase kinase inhibitor.
Scientists showed that BAP1 was dependent on the ASXL proteins and FOXK1/2 in facilitating gene activation across the genome. Although PR-DUB previously was shown to cooperate with PRC2, they observed minimal overlap and functional interaction between BAP1 and PRC2 in embryonic stem cells.
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Kolovos, P., Nishimura, K., Sankar, A., Sidoli, S., Cloos, P. A., Helin, K., & Christensen, J. (2020). PR-DUB maintains expression of critical genes through FOXK1/2 and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination. Genome Research, gr.261016.120. https://doi.org/10.1101/gr.261016.120 Cite
Calidi Biotherapeutics, Inc., announced that the Investigational New Drug application submitted by its partner, Personalized Stem Cells, Inc. They have received FDA approval for the treatment of COVID-19 and pneumonia patients using stem cell therapy.
[Calidi Biotherapeutics, Inc.]
Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
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Cynata Therapeutics Ltd. has announced positive results from the two-year follow-up of patients enrolled in the Phase I clinical trial of CYP-001, Cynata’s lead iPSC-derived Cymerus™ mesenchymal stem cell product.
[Cynata Therapeutics Inc.]
Investigators studied a family affected by dilated cardiomyopathy (DCM) due to a frameshift variant in LMNA. Human induced pluripotent stem cell (iPSC)–derived endothelial cells were generated from patients with LMNA-related DCM and phenotypically characterized.
[Science Translational Medicine]
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Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., Gaddam, S., Wang, K. C., Sallam, K., Boyd, J. H., Woo, Y. J., Rabinovitch, M., & Wu, J. C. (2020). Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Science Translational Medicine, 12(554). https://doi.org/10.1126/scitranslmed.aax9276 Cite
iPSC cells are laboratory-produced cells that combine the biological advantages of somatic adult and stem cells for cell-based therapy. The reprogramming of cells, such as fibroblasts, to an ESC-like state is done by the ectopic expression of transcription factors responsible for generating embryonic stem cell properties.
[International Journal of Molecular Sciences]
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Gois Beghini, D., Iwao Horita, S., Cascabulho, C. M., Anastácio Alves, L., & Henriques-Pons, A. (2020). Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies. International Journal of Molecular Sciences, 21(15), 5467. https://doi.org/10.3390/ijms21155467 Cite
The authors developed iPSCs from secondary progressive multiple sclerosis (SPMS)-affected donors and age-matched controls (CT). They confirmed their efficient and similar oligoprogenitor (OPC) differentiation capacity, although they reported SPMS-OPCs were transcriptionally distinguishable from their CT counterparts.
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