A Neutralizing IL-11 Antibody Reduces Vessel Hyperplasia in a Mouse Carotid Artery Wire Injury Model

Given the proliferation and adhesion defect of Trpm7−/− trophoblast stem cells and the ability of Trpm7−/− ESCs to develop to embryos in tetraploid embryo complementation assays, researchers postulated a critical role of TRPM7 in trophectoderm cells.
[Cell Reports]
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Mutations and Variants of ONECUT1 in Diabetes

Directed differentiation of human PSCs revealed that loss of One Cut Homeobox 1 (ONECUT1) impaired pancreatic progenitor formation and a subsequent endocrine program.
[Nature Medicine]
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Loss of TBX3 Enhances Pancreatic Progenitor Generation from Human Pluripotent Stem Cells

TBX3 mutant human PSC lines were generated using CRISPR/Cas9 genome editing. TBX3 loss led to impaired liver differentiation and an upregulation of pancreatic gene expression, including PDX1, during a hepatocyte differentiation protocol.
[Stem Cell Reports]
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Human Kidney Organoids Reveal the Role of Glutathione in Fabry Disease

Researchers modeled Fabry disease using human iPSC-derived kidney organoids and the CRISPR–Cas9 genome-editing system.
[Experimental & Molecular Medicine]
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Human Induced Pluripotent Stem Cell-Derived Platelets Loaded with Lapatinib Effectively Target HER2+ Breast Cancer Metastasis to the Brain

Investigators described methods for ex vivo generation of megakaryocytes and functional platelets from human iPSCs in a scalable fashion.
[Scientific Reports]
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Retinoic Acid Signaling in Heart Development: Application in the Differentiation of Cardiovascular Lineages from Human Pluripotent Stem Cells

Scientists discuss the role of retinoic acid (RA) in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification.
[Stem Cell Reports]
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Integrating Single-Cell Genomics Pipelines to Discover Mechanisms of Stem Cell Differentiation

The authors discuss strategies for scaling stem cell differentiation through multiplexed single-cell analysis, for evaluating molecular regulation of cell differentiation using new analysis algorithms, and methods for integration and projection analysis to classify and benchmark stem cell derivatives against in vivo cell types.
[Trends in Molecular Medicine]
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Plexin-B2 Orchestrates Collective Stem Cell Dynamics via Actomyosin Contractility, Cytoskeletal Tension and Adhesion

Scientists showed a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellular development of human embryonic stem cells and neuroprogenitor cells.
[Nature Communications]
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Cell-Based Therapies for Retinal Diseases: A Review of Clinical Trials and Direct to Consumer “Cell Therapy” Clinics

Scientists outline the particular approaches in the different published clinical trials for cell-based therapies for retinal diseases, and present the controversies surrounding experimental treatments offered outside of legitimate studies.
[Stem Cell Research & Therapy]
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Regulation of NANOG and SOX2 Expression by Activin A and a Canonical WNT Agonist in Bovine Embryonic Stem Cells and Blastocysts

Activation of activin A signaling stimulated NANOG expression during self-renewal of bovine ESC but suppressed cells expressing pluripotency markers in the blastocyst and increased cells expressing CDX2.
[Biology Open]
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Generation of a Transgenic Mouse Embryonic Stem Cell Line Expressing Dnmt1Y495C Mutation Associated with HSAN1E Disorder

Researchers employed non-homologous recombination and generated a mouse ESC line carrying a transgene expressing DNMT1 Y495C mutation in the wild-type background as a model for studying the abnormal neurogenesis due to this mutation.
[Stem Cell Research]
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