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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Small Molecule and Cell Contact-Inducible Systems for Controlling Expression and Differentiation in Mouse Embryonic Stem Cells
[Development] Scientists characterized three small molecule and two cell contact-inducible systems for gene expression in and differentiation of mESCs.
Deciphering Signaling Mechanisms and Developmental Dynamics in Extraembryonic Mesoderm Specification from hESCs
[Nature Communications] Investigators reported that the modulation of BMP, WNT, and Nodal signaling pathways can rapidly and efficiently induce the differentiation of both naive and primed hESCs into extraembryonic mesoderm-like cells.
Post-Gastrulation Amnioids As a Stem Cell-Derived Model of Human Extra-Embryonic Development
[Cell] Researchers presented an ESC-derived 3D model of the post-gastrulation amnion, post-gastrulation amnioids, that faithfully recapitulates extra-embryonic development up to four weeks post-fertilization, closely mimicking the functional traits of the human amniotic sac.
Effects of Bisphenol A and Retinoic Acid Exposure on Neuron and Brain Formation: a Study in Human Induced Pluripotent Stem Cells and Zebrafish Embryos
[Environmental Health Perspectives] The authors used hiPSCs and zebrafish embryos to investigate whether co-exposure to bisphenol A and exogenous retinoic acid (RA) can potentiate HOX gene expression and exert pleiotropic effects on RA signaling.
IPS HEART Granted Orphan Drug Designation in the EU for Becker Muscular Dystrophy
[IPS Heart (Businesswire)] IPS HEART has been awarded orphan drug designation in the EU by the European Medicines Agency for GIVI-MPCs unique ability to create new muscle with 100% full length dystrophin in Becker Muscular Dystrophy.
Proteogenomic Reprogramming to a Functional Human Blastomere-Like Stem Cell State via a PARP-DUX4 Regulatory Axis
[Cell Reports] Investigators showed that conventional hPSCs cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells.
Induced Neural Progenitor Specification from Human Pluripotent Stem Cells by a Refined Synthetic Notch Platform
[ACS Synthetic Biology] Scientists presented a method for cell-guided differentiation using the synthetic Notch receptor platform to regulate sonic hedgehog production and subsequent cell fate specification.
KDM3A and KDM3B Regulate Alternative Splicing in Mouse Pluripotent Stem Cells
[iScience] Scientists uncovered a surprising role for the KDM3 proteins in post-transcriptional regulation of mESCs. Proteomic analysis shows KDM3A and KDM3B interacting with RNA processing factors such as EFTUD2 and PRMT5.
LEC2 Induces Somatic Cell Reprogramming through Epigenetic Activation of Plant Cell Totipotency Regulators
[Nature Communications] Scientists showed that during somatic embryogenesis induced by overexpressing the totipotency-regulating transcription factor LEAFY COTYLEDON2 (LEC2) in Arabidopsis, CHH hypermethylation is deposited by the LEC2-activated RNA-directed DNA methylation pathway.
NAMPT Regulates Mitochondria and Oxidative Stress Level for Mouse Early Embryo Development
[Biological Research] Researchers disturbed the nicotinamide phosphoribosyltransferase (NAMPT) activity and employed immunofluorescence staining and live cell imaging to explore its roles during early embryo development.
KIF2A Stabilizes Intercellular Bridge Microtubules to Maintain Mouse Embryonic Stem Cell Cytokinesis
[Journal of Cell Biology] Scientists described a novel function for the kinesin-13 member KIF2A in cytokinesis. In genome-engineered mESCs, they found that KIF2A localizes to spindle poles during metaphase and regulates spindle length in a manner consistent with its known role as a microtubule minus-end depolymerase.
Leveraging CRISPR Activation for Rapid Assessment of Gene Editing Products in Human Pluripotent Stem Cells
[Stem Cell Reports] Scientists established a rapid and effective workflow for verifying genome-edited hPSC lines targeting unexpressed genes using CRISPR-mediated transcriptional activation.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
