ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

DMRT1 Regulates Human Germline Commitment

[Nature Cell Biology] Investigators followed the progression of nascent primordial germ cell-like cells derived from human ESCs in vitro.

Monolayer Platform to Generate and Purify Primordial Germ-Like Cells In Vitro Provides Insights into Human Germline Specification

[Nature Communications] The authors developed a simplified, monolayer method to differentiate hPSCs into primordial germ cells within three and a half days.

The COPD GWAS Gene ADGRG6 Instructs Function and Injury Response in Human iPSC-Derived Type II Alveolar Epithelial Cells

[American Journal of Human Genetics] Researchers applied an inducible CRISPR interference human induced pluripotent stem cells platform to explore ADGRG6 function in iPSC-derived human type 2 alveolar epithelial cells.

Derivation of Naïve Human Embryonic Stem Cells Using a CHK1 Inhibitor

[Stem Cell Reviews and Reports] Investigators showed that exposure of frozen human blastocysts to an inhibitor of checkpoint kinase 1 (CHK1) upon thaw greatly enhanced establishment of karyotypically normal late naïve human ESC cultures.

Mini-TCRs: Truncated T Cell Receptors to Generate T Cells from Induced Pluripotent Stem Cells

[Molecular Therapy-Methods & Clinical Development] Scientists presented the development of truncated T cell receptor (TCR) α and TCRβ chains, termed "Mini-TCRs". They successfully induced cytotoxic T lymphocytes from iPSCs by employing Mini-TCRs.

Accelerated Differentiation of Human Induced Pluripotent Stem Cells into Regionally Specific Dorsal and Ventral Spinal Neural Progenitor Cells for Application in Spinal Cord Therapeutics

[Frontiers in Neuroscience] Building upon previous work that demonstrated the rapid establishment of a primitive ectoderm population from hiPSCs, researchers described the production of a diverse population of both ventral spinal and dorsal horn progenitor cells.

Deepening the Role of Excitation/Inhibition Balance in Human iPSCs-Derived Neuronal Networks Coupled to MEAs during Long-Term Development

[Journal of Neural Engineering] The authors investigated whether and how the balance between excitation and inhibition influenced the spontaneous development of human-derived neuronal networks in vitro.

Cardiac Involvement in Patient-Specific Induced Pluripotent Stem Cells of Myotonic Dystrophy Type 1: Unveiling the Impact of Voltage-Gated Sodium Channels

[Frontiers in Physiology] Scientists identified two myotonic dystrophy type 1 patients with heart conduction abnormalities and characterized their hiPSC lines.

Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility

[Annual Review of Genetics] Investigators summarize the particular challenges presented by each organ system and describe how iPSC models are being used to address them.

Human Trials of Artificial Wombs Could Start Soon. Here’s What You Need to Know

[Nature News] Researchers at the Children’s Hospital of Philadelphia are seeking approval for the first human clinical trials of the device they’ve been testing, named the Extra-uterine Environment for Newborn Development, or EXTEND. The team has emphasized that the technology is not intended — or able — to support development from conception to birth.

Longitudinal scRNA-Seq Analysis in Mouse and Human Informs Optimization of Rapid Mouse Astrocyte Differentiation Protocols

[Nature Neuroscience] The authors used single cell RNA-sequencing/single nucleus RNA-sequencing to analyze over 298,000 cells and nuclei during macroglia differentiation from mouse embryonic and human-induced pluripotent stem cells.

Uncovering the Role of FOXA2 in the Development of Human Serotonin Neurons

[Advanced Science] Researchers uncovered the role of FOXA2 in human serotonin neuron (SN) development and improved the differentiation efficiency of human pluripotent stem cells into SNs by repressing FOXA2 expression.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.