ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Human Embryonic Stem Cells Exert Antitumor Effects on Prostate Cancer Cells in a Co-Culture Microenvironment

[Frontiers In Oncology] To facilitate the practical application of human embryonic stem cells (hESCs), scientists established a co-culture system consisting of prostate cancer cell lines and hESCs and investigated the antitumor activity of the supernatant of the co-culture system in vitro and in vivo.

Council Calls for Transparent, Equitable, and Open Access to Scholarly Publications

[Council of the European Union] The Council has adopted conclusions on the ‘high quality, transparent, open, trustworthy and equitable scholarly publishing’, in which it calls for immediate and unrestricted open access in publishing research involving public funds.

Thousands of Early-Career NIH Researchers Forming Union for First Time

[Nature News] Thousands of early-career researchers at the US National Institutes of Health (NIH) have kick-started the process of forming a union. They are calling on the agency — the world’s largest biomedical funder — to raise pay and improve benefits, as well as to bolster its policies and procedures on harassment and excessive workloads.

Extensive Programmed Centriole Elimination Unveiled in C. elegans Embryos

[Science Advances] Using notably lattice light-sheet microscopy, correlative light electron microscopy, and lineage assignment, investigators found that ~88% of cells lose centrioles during embryogenesis.

Ablation of ZC3H11A Causes Early Embryonic Lethality and Dysregulation of Metabolic Processes

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors reported the generation and phenotypic characterization of Zc3h11a knockout mice. Heterozygous null Zc3h11a mice were born at the expected frequency without distinguishable phenotypic differences compared with wild-type mice.

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis

[Molecular Neurobiology] Scientists identified a function of cyclin F to regulate substrate solubility and showed how cyclin F mechanistically underlay amyotrophic lateral sclerosis and frontotemporal dementia disease pathogenesis.

Reprogramming of Three-Dimensional Chromatin Organization in the Early Embryo

[Current Opinion In Structural Biology] Investigators highlight recent findings describing the dynamics and driving mechanisms for establishing 3D chromatin organization and discuss the role such organization has on gene regulation in early embryonic development.

AI Intensifies Fight against ‘Paper Mills’ That Churn Out Fake Research

[Nature News] Generative AI tools, including chatbots such as ChatGPT and image-generating software, provide new ways of producing paper-mill content, which could prove particularly difficult to detect.

Mesodermal FGF and BMP Govern the Sequential Stages of Zebrafish Thyroid Specification

[Development] By analyzing Pax2a and Nkx2.4b expression dynamics in relation to endodermal FGF and BMP signaling activities in zebrafish embryos, researchers identified a Pax2a-expressing thyroid progenitor population that shows enhanced FGF signaling but lacks Nkx2.4b expression and BMP signaling.

Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse Embryo

[Nature Communications] Scientists uncovered apical-to-basal RNA asymmetries in outer blastomeres of 16-cell stage mouse preimplantation embryos. Basally directed RNA transport was facilitated in a microtubule- and lysosome-mediated manner.

GSK-3484862 Targets DNMT1 for Degradation in Cells

[NAR Cancer] Researchers showed that GSK-3484862 targets DNMT1 for protein degradation in both cancer cell lines and murine ESCs. DNMT1 depletion was rapid, taking effect within hours following GSK-3484862 treatment, leading to global hypomethylation.

Mouse Embryonic Stem Cell-Derived Blood–Brain Barrier Model: Applicability to Studying Antibody Triggered Receptor Mediated Transcytosis

[Fluids And Barriers Of The Cns] Investigators developed a mouse blood-brain barrier model, composed of mouse embryonic stem cell-derived brain endothelial-like cells, employing a directed monolayer differentiation strategy.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.