ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Tbl1 Promotes Wnt/β-Catenin Signaling-Induced Degradation of the Tcf7l1 Protein in Mouse ESCs

[Journal of Cell Science] Investigators showed that the overexpression of transducin-β-like protein 1 (Tbl1) or its family member Tblr1 could decrease Tcf7l1 protein levels, while the knockdown of each increased Tcf7l1 levels without affecting Tcf7l1 transcription.

Dynamic Roles of Signaling Pathways in Maintaining Pluripotency of Mouse and Human Embryonic Stem Cells

[Cellular Reprogramming] The authors discuss the role of canonical signaling pathways implicated in regulation of pluripotency and differentiation particularly in mouse and human ESCs.

Mannose Controls Mesoderm Specification and Symmetry Breaking in Mouse Gastruloids

[Developmental Cell] To understand how metabolism impacted early mesoderm development, scientists used mESC-derived gastruloids, that co-expressed glucose transporters with the mesodermal marker T/Bra.

Two-Way Regulation of MgFe-LDH on ESC Cell Fate via Temporal Selective Activation of Different Cell Membrane Receptors

[Advanced Functional Materials] Investigators revealed that MgFe-layered double hydroxide (LDH) had bidirectional regulatory effects on the differentiation of mESCs into neural progenitor cells, essentially suppressing cell differentiation on the first day and promoting cell differentiation on the third day.

Smaug Regulates Germ Plasm Assembly and Primordial Germ Cell Number in Drosophila Embryos

[Science Advances] Investigators identified mechanisms that subsequently regulated germ plasm assembly in the early embryo. They showed that the Smaug RNA binding protein was transported into the germ plasm of the early embryo where it accumulated in the germ granules.

Low Initial Cell Density Promotes the Differentiation and Maturation of Human Pluripotent Stem Cells into Erythrocytes

[Stem Cells and Development] In the selection of low- and high-density inoculation conditions, scientists found that low-density culture performed better in the final red blood cell product with more cell output and increased average cellular hemoglobin content.

Impaired Osteogenesis in Human Induced Pluripotent Stem Cells with Acetaldehyde Dehydrogenase 2 Mutations

[International Journal of Stem Cells] Researchers investigated the effects of acetaldehyde dehydrogenase 2 (ALDH2) mutations on bone remodeling. They examined the effects of ALDH2 polymorphisms on in vitro osteogensis using hiPSCs.

Human Embryonic Genetic Mosaicism and Its Effects on Development and Disease

[Nature Genetics] Recent high-throughput sequencing studies have revealed that mosaicism is common, clone sizes often increase with age and specific variants can affect tissue function and disease development.

The Many Faces of H3.3 in Regulating Chromatin in Embryonic Stem Cells and Beyond

[Trends in Cell Biology] The authors provide an update with a focus on H3.3 functions in early mammalian development, considering the context of ESC maintenance and differentiation, to finally conclude with emerging roles in cancer development and cell fate transition and maintenance.

SCG Cell Therapy and A*star Launch Joint Labs with Collaboration Nearing S$30 Million to Advance iPSC Technology towards Scalable GMP Manufacturing of Cellular Immunotherapies

[SCG Cell Therapy] SCG Cell Therapy and the Agency for Science, Technology and Research (A*STAR) announced the launch of joint laboratories for cellular immunotherapies. This collaboration,aims to advance the development of iPSC technology to produce novel cell therapies that meet GMP standards.

Cell-Type-Specific mRNA Transcription and Degradation Kinetics in Zebrafish Embryogenesis from Metabolically Labeled Single-Cell RNA-Seq

[Nature Communications] Scientists combined single-cell RNA-Seq and metabolic labeling to capture temporal cellular transcriptomes of zebrafish embryos where newly-transcribed and pre-existing mRNA could be distinguished.

TEAD2 Initiates Ground-State Pluripotency by Mediating Chromatin Looping

[EMBO Journal] The authors systematically screened factors essential for ESC pluripotency, identifying transcriptional enhanced associate domain (TEAD) 2 as an ancillary factor maintaining ground-state pluripotency in 2i/leukemia inhibitory factor (LIF) ESCs and facilitating the transition from serum/LIF to 2i/LIF ESCs.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.