ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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Reversible Epiblast Regionalization Determines Differentiation Potential of Human Pluripotent Stem Cells

August 12, 2026

[Nature Biotechnology] Scientists explored variability in hPSC differentiation potential and the underlying epigenetic processes through the lens of epiblast anterior-posterior regionalization in vivo.

A Reproducible Three-Dimensional Model of Human Brain Tissue to Investigate Physiological and Disease-Associated Microglia Phenotypes

August 12, 2026

[Nature Neuroscience] Investigators developed a hiPSC-based three-dimensional cortical brain tissue model containing neurons, astrocytes, and microglia with high reproducibility, maturity and viability.

H2BK5ac Is Required for the Establishment of Inflammatory Potential in Mouse Embryonic Stem Cells following Differentiation

August 12, 2026

[Cell Reports] The authors reported that H2BK5ac regulates the acquisition of inflammatory potential in mouse ESCs during differentiation.

CtBP1/2 Restrict DUX-Dependent and Independent 2C-Like Programs in Mouse Embryonic Stem Cells

August 12, 2026

[EMBO Reports] Researchers showed that C-terminal binding protein 1/2 (CtBP1/2) restricts both DUX-dependent and independent 2-cell-like transcriptional programs in mESCs.

From Stem Cells to Somites: Revealing Genetic and Exogenous Factors of Human Embryogenesis

August 12, 2026

[Stem Cell Reports] The authors showed that pre-differentiation culture medium impacts the developmental potential of iPSCs, with StemFit medium and Matrigel embedding outperforming mTeSR Plus medium in generating robust somite-like structures.

Top2a Complexes with Trim28 to Orchestrate Stemness of Embryonic Stem Cells and Tumorigenesis

August 12, 2026

[Communications Biology] Using an unbiased proteomic approach, scientists discovered that Trim28, along with subunits of various chromatin remodeling complexes and modifiers, interacts with Type II topoisomerase α (Top2a) on ESC chromatin.

Microtubule Function in Pluripotent Mouse Embryonic Stem Cells

August 12, 2026

[Trends in Cell Biology] Investigators summarize recent advances in our understanding of the role of the microtubule cytoskeleton in pluripotency maintenance.

Sumitomo Pharma America Announces First Patient Receives Treatment in Phase I/IIa Study for its Investigational Therapy DSP-3077 for Retinitis Pigmentosa

August 12, 2026

[Sumitomo Pharma] Sumitomo Pharma America, Inc. announced that the first patient in its study evaluating DSP-3077 in the treatment of non-syndromic retinitis pigmentosa has undergone subretinal implantation. DSP-3077 is an investigative regenerative cell therapy that leverages allogeneic retinal sheets derived from iPSCs.

Mechanistic Insights Into Gene Regulation Driving Normal and Malignant Hematopoietic Development from Embryonic and Induced Pluripotent Stem Cell Differentiation

August 4, 2026

[Experimental Hematology] The following review highlights how embryonic and iPSC models are uncovering the gene regulatory mechanisms that drive normal and malignant blood cell development, advancing regenerative medicine and leukemia research.

RoslinCT and BlueRock Therapeutics Partner to Expand Access to Clinical-Grade Pluripotent Cell Lines for Cell Therapy Developers

July 29, 2026

[RoslinCT] RoslinCT announced a strategic partnership with BlueRock Therapeutics, a leader in stem cell therapeutic development, to broaden access to clinical-grade pluripotent stem cell lines for cell therapy developers.

Alu-Mediated SPAST Deletion Impairs Golgi Zinc Transport and Reveals a Druggable Vulnerability

July 29, 2026

[Signal Transduction and Targeted Therapy] The authors leveraged hPSC-derived cortical organoids and xenografts to model an Alu-mediated exon 17 deletion in the SPAST gene, a frequent cause of hereditary spastic paraplegia with dementia.

Distinct Differentiation Trajectories Leave Lasting Impacts on Gene Regulation and Function of V2a Neurons

July 29, 2026

[Nature Communications] Researchers differentiated human stem cells into V2a neurons through hindbrain- and spinal cord-like progenitor routes and profiled them by single nucleus multiomic sequencing.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.