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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Modeling X Chromosome Inactivation Using t5iLA Naive Human Pluripotent Stem Cells
[BMC Biology] By focusing on the transition between naive and primed pluripotent states, researchers highlighted the role of long non-coding RNA X-inactive specific transcript and epigenetic alterations in mediating X chromosome inactivation.
EIF3B Affects the Invasion and Metastasis of Hepatocellular Carcinoma Cells via the TGFBI/MAPK/ERK Pathway
[Annals of Hepatology] Researchers investigated the effect of eukaryotic initiation factor 3B (EIF3B) on the invasion and migration of HCC and its potential mechanism.
The Scaffolding Function of LSD1 Controls DNA Methylation in Mouse ESCs
[Nature Communications] Scientists showed that lysine-specific histone demethylase 1 (LSD1) was dispensable for mouse ESC self-renewal but was required for mouse ESC growth and differentiation. Reintroduction of a catalytically-impaired LSD1 (LSD1MUT) recovered the proliferation capability of mouse ESCs, yet the enzymatic activity of LSD1 was essential to ensure proper differentiation.
Characterization of Two iPSC Lines from Patients with Maternally Inherited Leigh (MILS) and Neuropathy, Ataxia, and Retinitis Pigmentosa (NARP) Syndrome Carrying the MT-ATP6 m.8993...
[Stem Cell Research] Investigators generated two iPSC lines from fibroblasts of patients carrying mutations at MT-ATP6 (m.8993 T>G).
Endogenous Retroviral ERVH48-1 Promotes Human Urine Cell Reprogramming
[Cell Regeneration] The researcher explored endogenous retroviruses (ERVs) functionality by examining single-cell transcriptomic profiles from human embryonic stem cells and urine cells. This led to the discovery of a unique ERVH48-1 expression pattern between these cell types.
A Monoclonal Antibody Recognizing CD98 on Human Embryonic Stem Cells Shows Anti-tumor Activity in Hepatocellular Carcinoma Xenografts
[Cancer Immunology Immunotherapy] Researchers generated a panel of monoclonal antibodies against surface proteins on human embryonic stem cells.
The Metabolic Profiles of Endogenous and Exogenous Substances in a Poor Metabolizer of Humanized CYP2D6 Model
[European Journal of Pharmaceutical Sciences] Investigators used embryonic stem cell targeting and CRISPR-Cas9 technology to create a humanized CYP2D6 mouse model by inserting the human wild-type CYP2D6 gene and knocking out the mouse Cyp2d locus.
Submission to Stem Cells Reviews and Reports
[Stem Cell Reviews and Reports] The use of allogeneic iPSC-derived cell therapies for regenerative medicine offers an affordable and realistic alternative to producing individual iPSC lines for each patient in need.
Parkinson’s iPSC Trial
[Nature Biotechnology] The USD FDA has given the green light to a clinical trial designed to test patient-derived (iPSCs in patients with Parkinson’s disease.
An Ode to Stem Cells
Leveraging the versatility of stem cells allows researchers to advance science across multiple disciplines.
[nan] Press Release
Effect of a FOXO1 Inhibitor on Trophoblast Differentiation from Human Pluripotent Stem Cells and ERV-Associated Gene Expression
[Regenerative Therapy] Scientists examined the effect of FOXO1 inhibition on the differentiation of naive human iPSCs into trophectoderm and trophoblast lineages.
Adipocyte Inflammation Is the Primary Driver of Hepatic Insulin Resistance in a Human iPSC-Based Microphysiological System
[Nature Communications] To address the need for an accurate in vitro model, researchers established an interconnected microphysiological system containing white adipocytes, hepatocytes, and proinflammatory macrophages derived from isogenic human induced pluripotent stem cells.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
