ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Manufacturing Parameters for the Creation of Clinical-Grade Human-Induced Pluripotent Stem Cell Lines From Umbilical Cord Mesenchymal Stromal Cells

[Stem Cells Translational Medicine] Scientists described the establishment of the first clinical-grade iPSC lines from umbilical cord mesenchymal stromal cells in Brazil.

Interlinked Bi-stable Switches Govern the Cell Fate Commitment of Embryonic Stem Cells

[FEBS Letters] Investigators demonstrated that steady-state dynamics involving two bistable switches which are interlinked via a stepwise and a mushroom-like manner orchestrate the fate specification of embryonic stem cells.

Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons

[Journal Of Proteome Research] Researchers conducted integrated proteomics, lipidomics, and metabolomics analyses with confident identification, accurate quantification, and reproducible measurements to compare the molecular profiles of human iPSCs and iPSC-derived neurons.

Generation of Induced Pluripotent Stem Cell Line NIMHi010-A from Dermal Fibroblast Cells of a Healthy Individual

[Stem Cell Research] Scientists established hiPSC line, NIMHi010-A of a 42-year-old healthy donor. The iPSC line was generated from human dermal fibroblasts using Sendai viruses carrying reprogramming factors c-MYC, SOX2, KLF4, and OCT4 under a feeder-free culture system.

Quiescence Enables Unrestricted Cell Fate in Naive Embryonic Stem Cells

[Nature Communications] Investigators showed that quiescent embryonic stem cells possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types.

Cellular Reprogramming as a Tool to Model Human Aging in a Dish

[Nature Communications] Scientists explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.

UC Irvine Advances Stem Cell Research with $4 Million CIRM Grant for Shared Resources Lab

[UCI News] The University of California, Irvine (UCI) received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center. The facility will offer essential technologies and training for the development of novel in vitro stem cell-based modeling that will serve researchers across the campus and the state.

Mouse SAS-6 Is Required for Centriole Formation in Embryos and Integrity in Embryonic Stem Cells

[eLife] Scientists reported that Sass6‑mutant mouse embryos lack centrioles, activate the mitotic surveillance cell death pathway and arrest at mid‑gestation. In contrast, SAS‑6 is not required for centriole formation in mouse ESCs, but is essential to maintain centriole architecture.

Generation of an Induced Pluripotent Stem Cell Line (SDQLCHi067-a) from a Patient with Subcortical Band Heterotopia Harboring a Heterozygous Mutation in DCX Gene

[Stem Cell Research] A human iPSCs line was established from a 4-year-1-month-old girl with subcortical band heterotopia carrying a heterozygous mutation in DCX. The generated iPSC line showed the ability to differentiate into three lineages in vitro and was confirmed by pluripotency markers and the original gene mutation.

Hallmarks of Totipotent and Pluripotent Stem Cell States

[Cell Stem Cell] The authors delve into the hallmarks of totipotent and pluripotent stem cells, shedding light on their key molecular and functional features.

Survival and Functional Integration of Human Embryonic Stem Cell-Derived Retinal Organoids After Shipping and Transplantation into Retinal Degeneration Rats

[Stem Cells And Development] Human ESC (hESC)-derived retinal organoids were differentiated from the hESC line H1, shipped overnight to another location, and then transplanted into the subretinal space of blind immunodeficient retinal degenerate rats.

3D Aligned Nanofiber Scaffold Fabrication with Trench-Guided Electrospinning for Cardiac Tissue Engineering

[Langmuir] A trench-guided electrospinning strategy was proposed to directly fabricate 3D aligned nanofiber scaffolds with alternative electrospinning and a direct ink writing process. The effect of the scaffolds was verified by culturing hiPS-cardiomyocytes (CM), which resulted in the uniform 3D distribution of aligned hiPSC-CMs with ∼1000 μm thickness.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.