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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
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New York Blood Center Enterprises and Biohub Launch Collaboration to Advance Cord Blood-Derived Stem Cell Platforms
[ New York Blood Center Enterprises] New York Blood Center Enterprises’ Lindsley F. Kimball Research Institute announced a scientific collaboration with Biohub to develop optimized methodologies for deriving iPSCs from defined immune cell populations isolated from cord blood units.
TCA Cycle Rewiring Underpins Histone Acetylation Sourcing and Cell-Fate Transitions during Exit from Naive Pluripotency
[Cell Stem Cell] Researchers mapped metabolite routing in pre- and post-implantation mouse embryos and across dynamic pluripotency transitions in stem cells, revealing that the tricarboxylic acid (TCA) cycle undergoes spatio-temporal rewiring rather than a simple shutdown.
Scaling and Self-Similarity in the Formation of the Embryonic Epigenome
[Nature Physics] Investigators showed that despite the complexity of epigenetic regulation, dynamical scaling and self-similarity of DNA methylation marks emerge in embryonic development.
NELFA Supports Naïve Pluripotency and Drives 8C-Like State in Human Embryonic Stem Cells
[Nature Communications] The authors showed that NELFA is dispensable in human primed ESCs but critical for naïve pluripotency, and its overexpression promotes the primed-to-naïve conversion.
The Nuclear Cap-Binding Complex Safeguards Stress-Resistant Protein Synthesis and Proliferation of Stem Cells
[Science Advances] Scientists showed that under stress, cap-binding complex-bound mRNAs recruit eIF2A, an alternative initiation factor, to sustain translation when eIF4E-dependent translation is inhibited.
RYBP Regulates Selective Genomic Binding of TrxG and PcG Components in Embryonic Stem Cell Fate Control
[EMBO Journal] Researchers reported that the polycomb repressive complex 1 subunit RYBP co-localizes with trithorax group (TrxG) component WDR5 and selectively enriches polycomb group (PcG) component RING1B in condensates in mESCs.
Actomyosin Contractility Is a Potent Suppressor of Mesoderm Induction by Human Pluripotent Stem Cells
[Journal of Cell Biology] Scientists showed that increasing contractility through constitutively active Rho kinase or myosin light-chain kinase unexpectedly blocks β-catenin–dependent mesoderm induction and prevents epithelial–mesenchymal transition.
Advances in Cell Therapy for Neural Repair
[Journal of Neuroscience] Cell therapies using derivatives of PSCs have emerged as promising approaches at restoring brain and spinal cord integrity, driving innovation from primary tissue transplants to the engineering of iPSC-derived neuronal and glial progenitors and now to complex multicellular brain and spinal cord organoids.
A Scalable Embryonic Stem Cell-Based Platform for Efficient Generation of Mitochondrial DNA Mutant Mice
[Proceedings of the National Academy of Sciences of the United States of America] Investigators developed a scalable embryonic stem cell–based platform for efficient production of mitochondrial DNA mutant mice.
EpCAM Supports Exit from Pluripotency of Embryonic Stem Cells via Eomes
[Cell Death & Disease] Researchers presented a role of epithelial cell adhesion molecule (EpCAM) in exit from pluripotency of murine ESCs to establish cardiomyocytes in embryoid bodies.
An Optimized Protocol for Efficient Derivation of Pancreatic Islets from Multiple Human Pluripotent Stem Cell Lines
[Stem Cell Reports] Investigators developed a robust protocol that generates functional stem cell-derived islets from all eight tested hPSC lines.
Generating Microglia-Integrated Cortical Organoids from Human Embryonic Stem Cells
[Stem Cell Reviews and Reports] Researchers presented a protocol for generating cortical organoids integrated with microglial progenitors derived from hESCs by differentiating hESCs into Yolk Sac Embryoid Bodies.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
