ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

FDA Limits Use of J&J Vaccine, Citing Safety Concerns

[The Scientist] The US FDA has limited the use of Johnson & Johnson’s single-shot coronavirus vaccine due to the small risk of developing a rare and potentially life-threatening blood clotting disorder.

Autophagy in PDGFRα+ Mesenchymal Cells Is Essential for Intestinal Stem Cell Survival

[Proceedings of the National Academy of Sciences of the United States of America] Autophagy was required for PDGFRα+ mesenchymal cells (PMC) metabolism and ileum stem cell and mammalian survival. Failure to maintain PMCs through autophagy may therefore contribute to inflammatory bowel diseases.

Revealing the Mechanisms of Weishi Huogu I Capsules Used for Treating Osteonecrosis of the Femoral Head Based on Systems Pharmacology with One Mechanism Validated...

[Journal of Ethnopharmacology] The effects of Weishi Huogu I capsule compounds identified through the systematic pharmacology analysis of the osteogenic transformation of human umbilical MSCs were validated in vitro.

Fast-Curing Injectable Microporous Hydrogel for In Situ Cell Encapsulation

[ACS Applied Bio Materials] When applied for in situ cell encapsulation, encapsulated human dermal fibroblasts and human MSCs were able to rapidly spread and proliferate in the pore space of the hydrogel.

Drug Repositioning of Polaprezinc for Bone Fracture Healing

[Communications Biology] Polaprezinc induced upregulation of osteogenesis-related genes and enhanced the osteogenic potential of human bone marrow-derived MSCs and osteoclast differentiation potential of mouse bone marrow-derived monocytes.

Oxidized High Mobility Group B-1 Enhances Metastability of Colorectal Cancer via Modification of Mesenchymal Stem/Stromal Cells

[Cancer Science] When bone marrow-MSCs pretreated with oxidized high mobility group box-1 were co-cultured with syngeneic cancer cells, cell proliferation and stemness of cancer cells were increased, and tumorigenesis and drug resistance were promoted.

Parkin-Mediated Mitophagy Protects against TNF-α-Induced Stress in Bone Marrow Mesenchymal Stem Cells

[Experimental Gerontology] Parkin-mediated mitophagy played protective role in bone marrow MSCs in response to TNF-α, which could be a crucial therapeutic target in the future.

Allogenic Umbilical Cord Blood-Mesenchymal Stem Cells Are More Effective than Antibiotics in Alleviating Subclinical Mastitis in Dairy Cows

[theriogenology] Investigators isolated, in vitro cultured, and characterized the umbilical cord-derived(UCB)-MSCs as well as UCB-MSC-extracellular vesicles.

Genotoxicity, Oxidative Stress and Transcriptomic Effects of Nitenpyram on Human Bone Marrow Mesenchymal Stem Cells

[Toxicology and Applied Pharmacology] Human bone marrow MSCs were employed as an in vitro model more relevant to humans to assess the potential genotoxicity of nitenpyram and to understand the underlying mechanisms at cellular and molecular levels.

Safety and Efficacy of the Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritic Knee: A 5-Year Follow-up Study

[Stem Cells Translational Medicine] Researchers assessed the mid-term safety and efficacy of the intra-articular injection of adipose-derived MSCs in patients with knee osteoarthritis.

Near-Infrared Light-Controlled and Real-Time Detection of Osteogenic Differentiation in Mesenchymal Stem Cells by Upconversion Nanoparticles for Osteoporosis Therapy

[ACS Nano] Researchers developed an upconversion nanoparticle-based photoresponsive nanoplatform for near-infrared light-mediated control of intracellular icariin release to regulate the osteogenic differentiation of MSCs for osteoporosis therapy.

Cellular Protrusions in 3D: Orchestrating Early Mouse Embryogenesis

[Seminars in Cell & Developmental Biology] The authors review how actin-rich protrusions are used by two major morphological cell types, epithelial and mesenchymal cells, during collective cell migration to sculpt the mouse embryo body.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.