ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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Highly Efficient Generation of Mature Megakaryocytes and Functional Platelets from Human Embryonic Stem Cells

December 3, 2024

[Stem Cell Research & Therapy] Researchers presented a novel approach to highly and efficiently generate mature megakaryocytes and functional platelets from human ESCs (hESCs). The in vivo functionality of hESC-derived platelets closely resembled that of natural human platelets.

Embryoid Body-Based Differentiation of Human-Induced Pluripotent Stem Cells into Cells with a Corneal Stromal Keratocyte Phenotype

December 2, 2024

[BMJ Open] Researchers established an innovative and effective method to generate corneal stromal keratocytes via the embryoid body-based differentiation of human iPSCs, which may be employed for cell-based therapy of corneal stromal opacities.

DEAD-Box RNA Helicase 10 Is Required for 18S rRNA Maturation by Controlling the Release of U3 snoRNA from Pre-rRNA in Embryonic Stem Cells

November 28, 2024

[Nature Communications] The authors discovered that DEAD-box RNA helicase 10 (DDX10) was indispensable for upholding cellular homeostasis and the viability of mouse ESCs. DDX10 participated in the process of liquid-liquid phase separation, which was necessary for efficient ribosome biogenesis.

Alloy Therapeutics Signs Collaboration and License Agreement with Takeda to Develop Cell Therapy Platform

November 27, 2024

[Alloy Therapeutics, Inc.] Alloy Therapeutics, Inc. announced a strategic collaboration and license agreement with Takeda Pharmaceutical Company Limited to develop Takeda’s proprietary iPSC derived CAR-T cell platform and iPSC-derived CAR-NK platform.

Phosphorylation-Mediated Disassembly of C-Terminal Binding Protein 2 Tetramer Impedes Epigenetic Silencing of Pluripotency in Mouse Embryonic Stem Cells

November 26, 2024

[Nucleic Acids Research] Researchers elucidated that DNA damage activated Chk2, leading to the phosphorylation of serine 164 on C-terminal binding protein 2 (Ctbp2).

Inhibition of Lung Tumorigenesis by Transient Reprogramming in Cancer Cells

November 26, 2024

[Cell Death & Disease] Investigators found that Oct4, Sox2, Klf4, and c-Myc expression limited the growth of transformed lung cells by inducing apoptosis and senescence. They identify Oct4 and Klf4 as the main individual reprogramming factors responsible for this effect.

Gain of 1q Confers an MDM4-Driven Growth Advantage to Undifferentiated and Differentiating hESC While Altering Their Differentiation Capacity

November 22, 2024

[Cell Death & Disease] Researchers showed that gains of 1q impacted the differentiation capacity to derivates of the three germ layers, leading to mis-specification to cranial placode and non-neural ectoderm during neuroectoderm differentiation.

Nuclear Receptor-SINE B1 Network Modulates Expanded Pluripotency in Blastoids and Blastocysts

November 22, 2024

[Nature Communications] Scientists established metrics for grading the resemblance of blastoids to mouse blastocysts, and identified the differential activation of gene regulons involved in lineage specification among various blastoid grades.

A Stepwise Mode of TGFβ-SMAD Signaling and DNA Methylation Regulates Naïve-to-Primed Pluripotency and Differentiation

November 22, 2024

[Nature Communications] Scientists introduced a stepwise paradigm in which Smad2/3 regulated the lineage priming and differentiation of mouse ESCs by collaboration with different effectors.

Generation of iPSC-Derived Human Venous Endothelial Cells for the Modeling of Vascular Malformations and Drug Discovery

November 22, 2024

[Cell Stem Cell] Investigators devised a robust protocol for the generation of human induced venous endothelial cells through manipulation of cell-cycle dynamics via the retinoic signaling pathway.

Single-Cell Transcriptomics Reveals the Molecular Basis of Human iPS Cell Differentiation into Ectodermal Ocular Lineages

November 20, 2024

[Communications Biology] Scientists used single-cell analyses to interrogate developing self-formed, ectodermal, autonomous multi-zones at key junctures throughout their formation as proxies of human eye development, in order to reveal the developmental trajectories of individual cell populations as they lose pluripotency and commit to specific ocular lineages.

A Comprehensive Human Embryo Reference Tool Using Single-Cell RNA-Sequencing Data

November 20, 2024

[Nature Methods] Researchers developed a universal reference for benchmarking human embryo models through the integration of six published human datasets covering development from the zygote to the gastrula.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.