ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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ERC Awards Proof of Concept Grants to 182 Researchers

July 6, 2026

[The European Research Council] The European Research Council (ERC) has announced the names of its grantees to be awarded the Proof of Concept Grants. Funding for this first round of 2026, worth €27.3 million, will go to 182 researchers.

Continuous Modeling of Primate Embryogenesis from Totipotency to Early Organogenesis

June 16, 2026

[Cell] Investigators successfully generate primate organogenetic embryoids from cynomolgus totipotent blastomere-like stem cells (cTBLCs). cTBLCs, reprogrammed from PSCs and stably maintained, can display key totipotent-like molecular and functional features resembling zygotes/2–4-cell blastomeres.

A Human Induced Pluripotent Stem Cell Model for the Holistic Study of Epithelial-to-Mesenchymal Transitions

June 16, 2026

[Nature Methods] Researchers showed that hiPSCs in defined cell culture geometries, two-dimensional colonies and three-dimensional lumenoids, enable multimodal measurements of epithelial-to-mesenchymal transition dynamics within a single experimental platform.

Generation of Human Appetite-Regulating Neurons and Tanycytes from Pluripotent Stem Cells

June 16, 2026

[Cell Stem Cell] Scientists demonstrated that human ventromedial hypothalamus and arcuate nucleus neurons can be generated from pluripotent stem cells by fine-tuned timing and duration of bone morphogenetic protein exposure.

Development of a Laminin-511 Inspired 3D Zwitterionic Hydrogel for Human Pluripotent Stem Cell Culture

June 16, 2026

[ACS Applied Materials & Interfaces] Researchers developed a laminin-511-inspired 3D zwitterionic hydrogel that supports long-term hPSC culture while maintaining pluripotency and differentiation potential.

Functional Maturation of Enteric Neurons Derived from Human Induced Pluripotent Stem Cells

June 16, 2026

[Stem Cell Reports] Using a defined protocol for the generation of iPSC-derived enteric neurons, scientists examined neuronal differentiation with immunohistochemistry, gene expression analysis, and cellular-resolution calcium imaging from day 21 to D57 of differentiation.

Canonical Autophagy Remains Inactive in Induced Pluripotent Stem Cells and Neuronal Progenitor Cells Following DNA Damage Induced by BPDE or Etoposide

June 16, 2026

[Scientific Reports] Using the hiPSC lines iPS11 and iPS12 and thereof derived NPCs, the authors investigated whether genotoxic stress induced by low doses of benzo[a]pyrene diolepoxide or etoposide can similarly activate autophagy for cancer cell lines..

Modeling Striatal Development and Disease with Human Pluripotent Stem Cells

June 16, 2026

[Inflammation and Regeneration] The authors summarize current approaches for generating striatal cell types from PSCs, with a particular focus on medium spiny neurons, the principal projection neurons of the striatum.

Heartseed, World’s First Clinical Trial of Catheter Administration of iPSC-Derived Cardiomyocyte Spheroids: First Patient Dosed

June 16, 2026

[Heartseed Inc.] Heartseed announced the successful dosing of the first patient in its domestic Phase I/II EMERALD study of HS-005, allogeneic iPSC-derived cardiomyocyte spheroids administered via catheter, targeting severe heart failure caused by ischemic heart disease or dilated cardiomyopathy.

FUJIFILM Cellular Dynamics Launches New iPSC Manufacturing Facility in Madison

June 3, 2026

[FUJIFILM Cellular Dynamics, Inc.] FUJIFILM Cellular Dynamics, Inc. celebrated the opening of its new headquarters and iPSC development and manufacturing facility in its Madison home. The new site is expected to quadruple the capacity for the company’s iPSC-based research products and services manufacturing footprint and expand capabilities across FUJIFILM Cellular Dynamics’ research product portfolio.

Reversible Superdeformability of hiPSC Epithelial Cortinoids

June 3, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Scientists highlighted how spherical epithelial shells, formed from hiPSCs, achieve “superdeformability” through reversible bending and tilting of their lateral cell edges.

Cryopreservable Dopaminergic Progenitors Derived from Human iPSCs with Accelerated Loss of Pluripotency and Early Functional Restoration in Parkinsonian Rats

June 3, 2026

[NPJ Parkinson'S Disease] Investigators developed an optimized protocol building upon our previously established neural induction method, with further refinements, to efficiently convert iPSCs into midbrain dopaminergic neurons.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.