ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Emergence of Large-Scale Cell Death through Ferroptotic Trigger Waves

[Nature] The authors demonstrated that ferroptosis, an iron- and lipid-peroxidation-dependent form of cell death, could propagate across human cells over long distances at constant speeds through trigger waves of reactive oxygen species.

Mapping the Chromatin Accessibility Landscape of Zebrafish Embryogenesis at Single-Cell Resolution by SPATAC-Seq

[Nature Cell Biology] Using SPATAC-seq, scientists profiled chromatin accessibility in more than 800,000 individual nuclei across 20 developmental stages spanning the sphere stage to the early larval protruding mouth stage.

Long-Term Culture of Human Pluripotent Stem Cells in Xeno-Free Condition Using Functional Polymer Films

[Advanced Materials] Scientists engineered a fully synthetic, xeno-free culture substrate, whose surface composition was tailored systematically for xeno-free culture of hPSCs.

Sequence-to-Expression Approach to Identify Etiological Non-Coding DNA Variations in P53 and cMYC-Driven Diseases

[Human Molecular Genetics] Researchers designed in vitro experiments to uncover the significance of occupancy and competitive binding between P53 and cMYC on common target genes.

PRC2-AgeIndex as a Universal Biomarker of Aging and Rejuvenation

[Nature Communications] The authors showed that low-methylated regions which were highly bound by polycomb repressive complex 2 (PRC2) in embryonic stem cells gained methylation with age in all examined somatic mitotic cells.

Reevaluation by the CRISPR/Cas9 Knockout Approach Revealed That Multiple Pluripotency-Associated lncRNAs Are Dispensable for Pluripotency Maintenance While Snora73a/B Is Essential for Pluripotency Exit

[Science China Life Sciences] Investigators employed CRISPR/Cas9-mediated knockout technology to explore the functions of eight lncRNAs previously reported to promote pluripotency in mouse ESCs.

The Differential Developmental Neurotoxicity of Valproic Acid on Anterior and Posterior Neural Induction of Human Pluripotent Stem Cells

[International Journal of Stem Cells] Researchers investigated the effects of valproic acid in a model where human pluripotent stem cells differentiate into anterior or posterior neural tissues.

O-GlcNAcase Regulates Pluripotency States of Human Embryonic Stem Cells

[Stem Cell Reports] Scientists showed that naive hESCs displayed lower levels of O-linked N-acetylglucosamine than primed hESCs.

Efficient and Reproducible Generation of Human iPSC-Derived Cardiomyocytes and Cardiac Organoids in Stirred Suspension Systems

[Nature Communications] The authors reported a robust stirred suspension cardiac differentiation protocol and performed extensive morphological and functional characterization of the resulting bioreactor-differentiated iPSC-cardiomyocytes.

Polycomb Function in Early Mouse Development

[Cell Death & Differentiation] Scientists discuss the functions and molecular mechanisms of both polycomb repressive complex 1 (PRC1) and PRC2 during early mouse embryo development, integrating new studies with existing knowledge.

Pioneering Code of Practice Released for Use of Stem Cell-Based Embryo Models in Research

[The University of Cambridge] The University of Cambridge, in partnership with the Progress Educational Trust, has led work to create the first ever UK guidelines for the generation and use of stem cell-based embryo models in research.

METAPHOR: Metabolic Evaluation through Phasor-Based Hyperspectral Imaging and Organelle Recognition for Mouse Blastocysts and Oocytes

[Proceedings of The National Academy of Sciences of The United States of America] Metabolic Evaluation through Phasor-based Hyperspectral Imaging and Organelle Recognition (METAPHOR) is a non-invasive, label-free imaging method thaT combined two-photon illumination and AI to deliver the metabolic profile of embryos and oocytes based on intrinsic autofluorescence signals.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.