Histone Variant macroH2A1.1 Enhances Non-homologous End Joining-Dependent DNA Double-Strand-Break Repair and Reprogramming Efficiency of Human iPSCs

Researchers evaluated the splicing isoforms of histone variant macroH2A1, macroH2A1.1 and macroH2A1.2, as potential regulators of DNA damage repair during iPSC reprogramming.
[Stem Cells]
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Selective Elimination of Pluripotent Stem Cells by PIKfyve Specific Inhibitors

Scientists showed that PIKfyve inhibitors could selectively eliminate pluripotent embryonal carcinoma cells, ESCs, and iPSCs under conditions where differentiated cells remained viable.
[Stem Cell Reports]
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Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells

Researchers studied maturity-onset diabetes of the young 1 using human iPSC-derived pancreatic β-like patient and isogenic control cell lines in two different 3D contexts.
[Diabetes]
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Integrated Fibroblast Growth Factor Signal Disruptions in Human iPS Cells for Prediction of Teratogenic Toxicity of Chemicals

Investigators developed a reporter assay using human iPSCs to detect changes in the fibroblast growth factor signaling pathway, a pathway essential for limb morphogenesis.
[Journal of Bioscience and Bioengineering]
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Transcriptional Programs Regulating Neuronal Differentiation Are Disrupted in DLG2 Knockout Human Embryonic Stem Cells and Enriched for Schizophrenia and Related Disorders Risk Variants

Scientists integrated human genetics with transcriptomic data from differentiation of human ESCs into cortical excitatory neurons.
[Nature Communications]
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Genome-Wide CRISPR Screen Identifies Puf60 as a Novel Stemness Gene of Mouse Embryonic Stem Cells

To study the mechanisms in ESC self-renewal, screening and identification of key genes maintaining ESC self-renewal were performed by a genome-wide CRISPR-Cas9 knockout virus library.
[Stem Cells and Development]
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Human Airway Lineages Derived from Pluripotent Stem Cells Reveal the Epithelial Responses to SARS-CoV-2 Infection

Investigators presented a human iPSC-derived airway epithelial platform, composed of the major airway epithelial cell types, that was permissive to SARS-CoV-2 infection.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Stem Cells at Odds with Telomere Maintenance and Protection

The authors discuss insights into telomere protection in ESCs versus somatic cells and summarize findings on telomerase regulation as a function of pluripotency.
[Trends in Cell Biology]
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ZFP207 Sustains Pluripotency by Coordinating OCT4 Stability, Alternative Splicing and RNA Export

The authors employed multiple functional analyses to characterize the role of Zinc Finger Protein 207 (ZFP207) in mouse ESCs.
[EMBO Reports]
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Japan University Uses iPS Cells to Treat Spinal Cord Injury for First Time

Keio University in Tokyo said it has started the world’s first clinical test using induced pluripotent stem cells, or iPS cells, to treat patients with spinal cord injuries.
[Kyodo News]
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Establishment of a Developmental Toxicity Assay Based on Human iPSC Reporter to Detect Fibroblast Growth Factor Signal Disruption

Scientists proposed a reporter assay that utilized human iPSCs to detect changes in fibroblast growth factor signaling, which was essential for limb morphogenesis.
[iScience]
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