SPEN Is Required for Xist Upregulation during Initiation of X Chromosome Inactivation

The authors showed that SPEN played an important role in initiation of X chromosome inactivation. Spen null female mouse ESCs were defective in Xist upregulation upon differentiation.
[Nature Communications]
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A Novel RNA-Mediated Mechanism Causing Down-Regulation of Insulating Promoter Interactions in Human Embryonic Stem Cells

Scientists integrated genome-wide datasets of RNA-chromatin and promoter-genome interactions in human ESCs to identify putative RNA-mediated promoter interactions.
[Scientific Reports]
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Functional Human Gastrointestinal Organoids Can Be Engineered from Three Primary Germ Layers Derived Separately from Pluripotent Stem Cells

Researchers developed an organoid assembly approach starting with cells from the three primary germ layers—enteric neuroglial, mesenchymal, and epithelial precursors—that were derived separately from human PSCs.
[Cell Stem Cell]
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Generation of Developmentally Competent Oocytes and Fertile Mice from Parthenogenetic Embryonic Stem Cells

Investigators showed that an unlimited number of oocytes could be derived from pparthenogenetic ESCs and produce healthy offspring.
[Protein & Cell]
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β-Catenin Links Cell Seeding Density to Global Gene Expression during Mouse Embryonic Stem Cell Differentiation

The authors revealed that the expression of thousands of genes in mouse ESCs was affected by cell seeding density and that low cell density enhanced the efficiency of differentiation.
[iScience]
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AgeX Therapeutics’ Licensee ImStem Biotechnology Announces First US Multiple Sclerosis Patient Dosed with IMS001

AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc., a biopharmaceutical company developing human ESC-derived mesenchymal stem cells, has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.
[AgeX Therapeutics, Inc.]
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$5.5 Million CIRM Grant to Fund Development of New Cervical Spinal Cord Injury Therapeutic

Aileen Anderson, director of the University of California Irvinc’s Sue & Bill Gross Stem Cell Research Center and professor of physical medicine & rehabilitation, has been awarded a 30-month, $5.5 million grant from the California Institute for Regenerative Medicine (CIRM).
[UCI News]
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Three Researchers Honoured for Groundbreaking Work on Ovarian Cancer, Stem Cells and Blood Transfusions

Each year, the Ottawa Hospital honours three outstanding researchers for discoveries that are having an impact around the world. This year’s honourees have led game-changing discoveries and clinical trials in areas such as ovarian cancer, stem cells and blood transfusions.
[Ottawa Citizen]
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AgeX Therapeutics’ Licensee ImStem Biotechnology Announces First U.S. Multiple Sclerosis Patient Dosed with IMS001

AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc. has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.
[AgeX Therapeutics, Inc. (BusinessWire, Inc.)]
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Generation and Characterization of Stable Pig Pregastrulation Epiblast Stem Cell Lines

Guided by insights from a large-scale single-cell transcriptome analysis of pig embryos from embryonic day (E) 0 to E14, the authors developed an in vitro culture medium for establishing and maintaining stable PSC lines from pig E10 pregastrulation epiblasts.
[Cell Research]
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Lysophosphatidic Acid Shifts Metabolic and Transcriptional Landscapes to Induce a Distinct Cellular State in Human Pluripotent Stem Cells

Scientists reported that the metabolic landscape of human PSCs was shifted by signaling lipid lysophosphatidic acid (LPA), which naturally exists. LPA led to a distinctive transcriptome profile that was not associated with de novo lipogenesis.
[Cell Reports]
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