ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Differentiation and Maturation Effect of All-Trans Retinoic Acid on Cultured Fetal RPE and Stem Cell-Derived RPE Cells for Cell-Based Therapy

[Current Eye Research] Scientists investigated the culture-induced changes in passaged fetal retinal pigment epithelium (fRPE), hESC-RPE and hiPSC-RPE cells and explored the differentiation and maturation effect of all-trans retinoic acid on cells for manufacturing and screening high quality RPE cells for clinical transplantation.

Induction of Mouse Totipotent Stem Cells by a Defined Chemical Cocktail

[Nature] Investigators demonstrated induction and long-term maintenance of totipotent stem cells from mPSCs by a combination of three small molecules, TTNPB, 1-Azakenpaullone, and WS6.

CTCF Organizes Inter-A Compartment Interactions through RYBP-Dependent Phase Separation

[Cell Research] Researchers designed and verified an induced CTCF phase separation system in ESCs, which facilitated inter-A compartment interactions, improved self-renewal of ESCs, and inhibited their differentiation toward neural progenitor cells.

G1/S Restriction Point Coordinates Phasic Gene Expression and Cell Differentiation

[Nature Communications] Researchers evaluated the link between G1/S restriction point activation, phasic gene expression, and cellular differentiation.

The 22q11.2 Region Regulates Presynaptic Gene-Products Linked to Schizophrenia

[Nature Communications] Investigators showed that upon induced pluripotent stem cells differentiation into neural progenitor cells, the deletion acted in trans to alter the abundance of transcripts associated with risk for neurodevelopmental disorders including autism.

KCNQ1-Deficient and KCNQ1-Mutant Human Embryonic Stem Cell-Derived Cardiomyocytes for Modeling QT Prolongation

[Stem Cell Research & Therapy] KCNQ1 was knocked out in hESC H9 line using the CRISPR/cas9 system. KCNQ1-deficient and KCNQ1-mutant hESCs were differentiated into cardiomyocytes through a chemically defined differentiation protocol.

Hypoxia Drives Hematopoiesis with the Enhancement of T Lineage through Eliciting Arterial Specification of Hematopoietic Endothelial Progenitors from hESC

[Stem Cell Research & Therapy] Investigators reported a novel culture system for hematopoietic differentiation from hESCs with optimal cytokines combinations under hypoxia condition.

HDAC Inhibitor and Proteasome Inhibitor Induce Cleavage and Exosome-Mediated Secretion of HSP90 in Mouse Pluripotent Stem Cells

[Biochemical and Biophysical Research Communications] HDAC inhibitors and proteasome inhibitors induced heat shock protein 90 (HSP90) cleavage in the mouse ESC line R1, and the cleaved HSP90 was barely found in the cells and instead secreted out of the cells through the exosome.

Generation of Universal Natural Killer Cells from a Cryopreserved Cord Blood Mononuclear Cell-Derived Induced Pluripotent Stem Cell Library

[Febs Open Bio] The authors prepared human leukocyte antigen (HLA)-matched iPSCs using HLA common haplotype homozygous donors from cryopreserved human cord blood sourced from the Tianjin Cord Blood Public Bank.

Human Pluripotent Stem Cells for the Modelling of Retinal Pigment Epithelium Homeostasis and Disease: A Review

[Clinical & Experimental Ophthalmology] The authors review the current knowledge gained in understanding the molecular events involved in retinal disease using hPSC-derived retinal models, in particular retinal pigment epithelium models.

A Comprehensive Review on the Role of ZSCAN4 in Embryonic Development, Stem Cells, and Cancer

[Stem Cell Reviews and Reports] Scientists discuss the multifaceted role of ZSCAN4 in embryonic development, embryonic stem cells, induced pluripotent stem cells, cancer, and germ cells.

TreeFrog Therapeutics Launches a $100,000 Research Grant in Regenerative Medicine

[TreeFrog Therapeutics] TreeFrog Therapeutics announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell biology and regenerative medicine.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.

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