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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
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RoslinCT and BlueRock Therapeutics Partner to Expand Access to Clinical-Grade Pluripotent Cell Lines for Cell Therapy Developers
[RoslinCT] RoslinCT announced a strategic partnership with BlueRock Therapeutics, a leader in stem cell therapeutic development, to broaden access to clinical-grade pluripotent stem cell lines for cell therapy developers.
Alu-Mediated SPAST Deletion Impairs Golgi Zinc Transport and Reveals a Druggable Vulnerability
[Signal Transduction and Targeted Therapy] The authors leveraged hPSC-derived cortical organoids and xenografts to model an Alu-mediated exon 17 deletion in the SPAST gene, a frequent cause of hereditary spastic paraplegia with dementia.
Distinct Differentiation Trajectories Leave Lasting Impacts on Gene Regulation and Function of V2a Neurons
[Nature Communications] Researchers differentiated human stem cells into V2a neurons through hindbrain- and spinal cord-like progenitor routes and profiled them by single nucleus multiomic sequencing.
Signaling Mechanisms and Dynamics Governing the Myocardial-Epicardial Fate Switch during Human Cardiogenesis
[Science Advances] The authors developed a hPSC-based cardiac development model and employed time-course single-cell RNA sequencing to delineate cardiac lineage specification trajectories.
Tissue Tension Permits β-Catenin Phosphorylation to Drive Mesoderm Specification in Human Embryonic Stem Cells
[Developmental Cell] Using an ectopically expressed nonphosphorylatable mutant of β-catenin)in hESC colonies, scientists provided evidence that impeding tension-dependent Src-mediated β-catenin phosphorylation compromises BMP4-driven Brachyury expression.
Human Induced Pluripotent Stem Cell-Derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model Without Triggering Ventricular Arrhythmias
[Journal of the American Heart Association] Investigators reported results from a first-in-human, open-label study of iPSC-neural stem/progenitor cells transplantation in four patients with subacute cervical complete spinal cord injury.
USP15 Mutation Associated with Autism Spectrum Disorder Alters Progenitor Fate and Neuronal Maturation in Human Brain Organoids
[Molecules and Cells] Researchers investigated USP15, a deubiquitinating enzyme with rare damaging variants identified in individuals with autism spectrum disorder, using isogenic human iPSC-derived brain organoids and single-cell transcriptomics.
Progressing Regenerative Medicine: Integrating Bioprinting Platforms for Stem Cell Applications
[Stem Cell International] Investigators critically evaluate bioprinting strategies tailored for stem cell applications, including the selection of stem cell sources, bioink formulation, crosslinking methodologies, and dynamic culture systems.
A Universal 6il/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells across Mammalian Species
[Cell Research] Investigators reported the development of a defined, serum-free culture system, termed 6iL/E4, that enables the derivation and long-term self-renewal of ESCs across diverse mammalian species.
Generation of Spermatogonia from Human and Non-Human Primate Pluripotent Stem Cells
[Cell Stem Cell] Researchers developed a system to differentiate hiPSCs into primordial germ cell-like cells that self-organize with mouse fetal testicular cells into seminiferous tubule-like structures within a xenogeneic reconstituted testis.
Tissue Tension Permits β-Catenin Phosphorylation to Drive Mesoderm Specification in Human Embryonic Stem Cells
[Developmental Cell] Using an ectopically expressed nonphosphorylatable mutant of β-catenin in hESC colonies, scientists provideed evidence that impeding tension-dependent Src-mediated β-catenin phosphorylation compromises BMP4-driven Brachyury expression.
Gata3 Dosage Governs Primitive Endoderm Versus Trophectoderm Specification in Embryonic Stem Cells
[EMBO Reports] The authors demonstrated that Gata3 functions as a dosage-sensitive regulator directing mutually exclusive lineage programs in mESCs.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
