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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
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Harvard, Yale Researchers Awarded $46 Million Grant To Study Autism, Brain Development
[Harvard Medical School] A $46 million grant from a new autism research initiative, Aligning Research to Impact Autism, is turbocharging efforts at Harvard and Yale to understand human brain development and provide insight into the roots of profound autism.
Site-Specific Programming Characterizes Dynamic Post-Translational Acetylation of Histone H2B Lysine 108 in Mouse Embryonic Stem Cells
[Nature Communications] Researchers established a genetic code expansion-based platform in mESCs for site-specific proteomic mapping and functional analysis within native chromatin. Using this platform, they revealed Rps19bp1 promotes Sirt1-mediated deacetylation of histone H2B lysine 108 acetylation.
Induced Pluripotent Stem Cells from Discovery to Translation
[Nature Medicine] The authors evaluate the technological and translational trajectories that have defined the iPSC era and analyzes the operational barriers to therapeutic development.
Ploidy-Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells
[Cell Proliferation] Investigators leveraged their isogenic haploid, diploid and triploid hESC lines to study the effect of ploidy on the response to four different anticancer drugs. They showed that triploid cells are more sensitive to chemotherapy-induced apoptosis and cell cycle arrest than diploid and haploid cells.
Methylome Profiling of SetDB1-Deficient ESCs Reveals Coordinated Epigenetic Cross-Talk during Pluripotency
[Stem Cell Reports] Given the interplay between DNAme and the other epigenetic features, researchers profiled DNA methylation following Setdb1 knockout in ground-state and serum-grown mESCs to illuminate DNAme-dependent and -independent functions of SetDB1.
Post-Transcriptional Regulation of Profilin-2 by microRNAs and RNA-Binding Proteins Forms a Critical Regulatory Node for Early Embryonic Cell Fate Decisions
[PLoS Genetics] Researchers demonstrated that post-transcriptional regulation of the Profilin 2 transcript is essential for differentiation of ESCs into the primary germ layer lineages.
A Human Stem Cell Model of Neuroblastoma Identifies Four Chromosome 17q Genes That Drive Tumor Initiation and Progression
[Cancer Letters] Researchers used a hPSC model of neuroblastoma to show that 17q+ cooperates with MYCN amplification to accelerate tumorigenesis compared to MYCN amplification alone.
cP1P Maintains Long-Term Pluripotency in Human Pluripotent Stem Cells
[International Journal of Stem Cells] Scientists introduced O-cyclic phytosphingosine-1-phosphate (cP1P), a novel culture additive structurally analogous to S1P, which markedly enhances hPSC self-renewal and survival. They demonstrated that cP1P supplementation promotes long-term proliferation of hPSCs.
Greenstone Biosciences Awarded Breakthrough T1D Grant to Advance Islet Cell Platform
[Greenstone Biosciences (Business Wire)] Greenstone Biosciences has been awarded a Breakthrough T1D Industry Discovery and Development Partnership grant to develop a T1D-derived islet cell platform aimed at understanding and protecting insulin-producing β cells in people with type 1 diabetes.
Engineered Human iPSC-Derived Dendritic Cells Dressed with Tumor MHC Complexes As a Cancer Vaccine
[Cell Stem Cell] Investigators presented an approach that involves differentiating universal major histocompatibility complex (MHC)-deficient hiPSCs into CCR7+ migratory dendritic cells.
Modeling Sympathetic Neuro-Cardiac Interactions in a hiPSC-Based Microphysiological System
[Lab on a Chip] The authors presented a novel microphysiological system using a compartmentalized microfluidic device to integrate co-cultured hiPSC-derived cardiomyocytes and sympathetic neurons.
Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors
[Stem Cell Reports] The therapeutic potential of autologous-derived dendritic cells is challenged by the number and quality produced and the diversity of antigens presented. Researchers addressed this limitation by developing a protocol to generate induced pruriceptors from hiPSCs.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
