Umbilical & Placental Cell News

Umbilical & Placental Cell News is an online resource dedicated to sharing the newest publications, reviews, and news updates in the field of umbilical and placental cell research.

Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Acute Graft versus Host Disease by Elevating Phytosphingosine

[Experimental Hematology] Investigators revealed the efficacy of human umbilical cord MSCs in alleviating acute graft-versus-host disease in a murine model, with striking changes in metabolism and significantly elevated phytosphingosine levels due to sphingolipid metabolism.

Placenta Powder-Infused Thiol-Ene PEG Hydrogels as Potential Tissue Engineering Scaffolds

[Biomacromolecules] Placenta powder, made from decellularized human placenta, was physically incorporated into synthetic poly(ethylene glycol)-based hydrogels via ultraviolet-initiated thiol-ene coupling.

Placental Mesenchymal Stem Cells Ameliorate NLRP3 Inflammasome-Induced Ovarian Insufficiency by Modulating Macrophage M2 Polarization

[Journal of Ovarian Research] Injection of human placental MSCs improved ovarian function and reproductive ability of premature ovarian insufficiency rats compared to the sham and hormone groups.

A Differentiation Roadmap of Murine Placentation at Single-Cell Resolution

[Cell Discovery] To decipher cell compositions and developmental processes, the authors systematically profiled the single-cell transcriptomes of trophoblast cells from extraembryonic tissues and placentae at one-day intervals.

Human Umbilical Cord Mesenchymal Stem Cells Conditioned Medium Exerts Anti-Tumor Effects on KGN Cells in a Cell Density-Dependent Manner through Activation of the Hippo...

[Stem Cell Research & Therapy] Researchers explored the effect of human umbilical cord MSCs-conditioned medium on granulosa tumor cell line cells at low or high density.

The Role of Ferroptosis in Placental-Related Diseases

[Reproductive Sciences] Scientists summarize the latest progress in trophoblastic ferroptosis research on placental-related diseases, provide references for further understanding of its pathogenesis, and propose new strategies for the prevention and treatment of placental-related diseases.

Human Umbilical-Cord-Derived Mesenchymal Stem Cells in Combination with Rapamycin Reduce Cartilage Degradation via Inhibition of the AKT/mTOR Signaling Pathway

[Immunopharmacology And Immunotoxicology] Scientists explored the role of rapamycin combined with human umbilical-cord-derived MSCs in osteoarthritis (OA)rabbits in vivo. OA rabbits received an intra-articular injection of a collagenase solution.

Neuroprotective Mechanism of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving the Phenotype Polarization of Microglia via the PI3K/AKT/Nrf2 Pathway in Vascular Dementia

[Synapse] Vascular dementia (VaD) rat model was established by bilateral common carotid artery ligation andhuman umbilical cord MSC derived extraellular vesicles (EVs) were extracted. VaD rats were injected with Evs through the tail vein.

Monash Awarded More than $53M through MRFF for Medical and Health Research

[Monash University] The Australian Government has awarded more than $53M through the Medical Research Future Fund (MRFF) to 21 Monash researchers for research into cardiovascular disease, respiratory disease, dementia, cancer, primary health care, nutrition, and more.

Placental Cell Type Deconvolution Reveals That Cell Proportions Drive Preeclampsia Gene Expression Differences

[Communications Biology] Scientists generated single-cell RNA-sequencing samples for integration with existing data to create the largest deconvolution reference of 19 fetal and eight maternal cell types from placental villous tissue.

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosome Suppresses Programmed Cell Death in Traumatic Brain Injury via PINK1/Parkin-Mediated Mitophagy

[CNS Neuroscience & Therapeutics] The authors investigated the protective effects of HucMSC-derived exosome in both in vivo and in vitro traumatic brain injury models.

Fetal Membranes Exhibit Similar Nutrient Transporter Expression Profiles to the Placenta

[Placenta] Researchers determined nutrient transport expression in human fetal membranes (FM) and FM cells and compared expression with placental tissues and BeWo cells.

Summarizing the latest research and reviews since 2009, Umbilical & Placental Cell News, previously known as Cord Blood News, keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cells, placental cells, amniotic fluid and membrane-derived cells, and all their derivatives. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.