Umbilical & Placental Cell News

Umbilical & Placental Cell News is an online resource dedicated to sharing the newest publications, reviews, and news updates in the field of umbilical and placental cell research.

Different Probiotic Strains Alter Human Cord Blood Monocyte Responses

[Pediatric Research] Scientists investigated the effect of probiotics on the functions of neonatal monocytes in an in vitro model using three different strains and mononuclear cells isolated from cord blood.

Human Placental Barrier-Brain Organoid-on-a-Chip for Modeling Maternal PM2.5 Exposure

[Science of the Total Environment] Researchers constructed a placental barrier-brain organoid-on-a-chip model, which enabled them to investigate the effects of maternal PM2.5 exposure on the human fetal system including the placental barrier and fetal brain.

Time Course and Mechanistic Analysis of Human Umbilical Cord Perivascular Cell Mitigation of Lipopolysaccharide-Induced Systemic and Neurological Inflammation

[Cytotherapy] Researchers evaluated the time course and mechanisms by which human umbilical cord perivascular cells mitigatef lipopolysaccharide-induced systemic and neurological inflammation in immunocompetent mice.

MSC Based Gene Delivery Methods and Strategies Improve the Therapeutic Efficacy of Neurological Diseases

[Bioactive Materials] Investigators focus on gene transport technologies for engineering MSCs and the application of strategies for selecting optimal delivery genes.

Cord Blood Transplantation for Nonmalignant Disorders: Early Functional Immunity and High Survival

[Blood Advances] The authors evaluated the two-year Overall Survival after umbilical cord blood transplantation in patients with non-malignant disorders enrolled on a prospective clinical trial using either 5/6 or 6/6 umbilical cord blood as cell source.

Comparison of Human Acellular Amniotic Membranes with Acellular Amniotic Membranes Pretreated with MPLA for Repair of Fascia in Rats

[Cell and Tissue Banking] Researchers compared the effectiveness of amniotic membrane and amniotic membrane pretreated with monophosphoryl lipid A (MPLA) for repairing the fascia of the abdomen with tension sutures.

Preparation of Single-Cell Suspensions from the Human Placenta

[Nature Protocols] Researchers described a protocol for the preparation of high-quality single-cell suspensions from human placental tissues—namely, the basal plate, placental villi and chorioamniotic membranes.

The Multifaceted Role of GCM1 during Trophoblast Differentiation in the Human Placenta

[Proceedings of the National Academy of Sciences of the United States of America] Human trophoblast stem cells were used to corroborate the role of glial cells missing-1 (GCM1) in syncytiotrophoblast formation and uncover its critical role in extravillous trophoblast development.

Small Extracellular Vesicles Derived from Nrf2-Overexpressing Human Amniotic Mesenchymal Stem Cells Protect against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting NLRP3

[Biology Direct] Scientists tested whether small extracellular vesicles derived from Nrf2-overexpressing hAMSCs (Nrf2-sEVs) could protect against ALI.

Regulation of the Placental Growth Factor Mediated by Sumoylation and Expression of miR-652-3p in Pregnant Women with Early-Onset Preeclampsia

[Bulletin of Experimental Biology and Medicine] Investigators studied regulation of the expression of placental growth factor that play an important role in the trophoblast cells functions and reduced production of which by the placenta is associated with gestational complications.

MiR-141–3p Promotes Hypoxia-Induced Autophagy in Human Placental Trophoblast Cells

[Reproductive Biology] The authors investigated the role of miR-141–3p in autophagy induced by hypoxia in human placental trophoblast cells. They found that hypoxia induced autophagy in trophoblast cells and dramatically elevated the expression of miR-141–3p.

Effects of Glucose on the Proliferation of Human Umbilical Cord Blood Hematopoietic Stem Cells

[Cell and Tissue Banking] Scientists demonstrated the relationship between glucose and the activation of the NLR family of pyrin domain-containing 3 inflammasome.

Summarizing the latest research and reviews since 2009, Umbilical & Placental Cell News, previously known as Cord Blood News, keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cells, placental cells, amniotic fluid and membrane-derived cells, and all their derivatives. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.