Umbilical & Placental Cell News

Umbilical & Placental Cell News is an online resource dedicated to sharing the newest publications, reviews, and news updates in the field of umbilical and placental cell research.

Molecular Analysis and Comparison of CD34+ and CD133+ Very Small Embryonic-Like Stem Cells (VSELs) Purified from Umbilical Cord Blood (UCB)

[Cytometry Part A] Researchers performed initial molecular characterization of CD34+Lin-CD45- and CD133+Lin-CD45- UCB-derived VSELs populations for expression of selected pluripotency markers and compared these cells at the proteomic level.

Placental Homing Peptide Guides HIF1α-Silenced Exosomes Conjugates for Targeted Enhancement of Invasion of Trophoblast Cells

[Molecular Medicine Reports] Scientists developed a method for targeted delivery of HIF1α‑silenced exosomes to the placenta. HIF1α was overexpressed in JEG‑3 cells.

Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Facilitates Injured Endometrial Restoring in Early Repair Period through miR-202-3p Mediating Formation of ECM

[Stem Cell Reviews And Reports] Scientists aimed to investigate the role of hucMSCs-derived exosomal microRNA-202-3p in endometrial damage repair.

Intravenous Injection of Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorates Not Only Blood Glucose but Also Nephrotic Complication of Diabetic Rats through Autophagy-Mediated Anti-Senescent...

[Biology Of Reproduction] Researchers investigated the regulation of placentas and uterus remodeling and involvement of E2 in gestational diabetes mellitus.

Regulation of Uterus and Placenta Remodeling under High Estradiol Levels in Gestational Diabetes Mellitus Models

[Stem Cell Research & Therapy] Investigators established in vitro and in vivo models for gestational diabetes mellitus placentas by culturing BeWo cells under hyperglycemic concentration, and treating pregnant rats with streptozotocin.

Application of Mesenchymal Stem Cells (MSCs) in Neurodegenerative Disorders: History, Findings, and Prospective Challenges

[Pathology - Research and Practice] The authors compared and contrasted the numerous mesenchymal cell sources and their cellular features. These many sources of mesenchymal cells included adipocyte cells, fetal umbilical cord tissue, and bone marrow.

Single Cell Profiling at the Maternal–Fetal Interface Reveals a Deficiency of PD-L1+ Non-Immune Cells in Human Spontaneous Preterm Labor

[Scientific Reports] Among the immune cells, maternal PD1+ CD8 T cell subsets were less abundant in term laboring compared to term non-laboring women. Among the non-immune cells, PD-L1+ maternal (stromal) and fetal (extravillous trophoblast) cells were less abundant in preterm laboring compared to term laboring women.

Comparison of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, and Umbilical Cord Tissue in Regeneration of a Full-Thickness Tendon Defect In Vitro...

[Biochemistry And Biophysics Reports] Researchers evaluated the potential of one marrow-, umbilical cord blood- and umbilical cord-MSC to differentiate into tendon-like cells in tensioned three-dimensional construct using gene and histological analysis.

Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Oxidative Stress-Induced Islet Impairment via the Nrf2/HO-1 Axis

[Journal Of Molecular Cell Biology] Investigators showed that intravenous injection of human umbilical cord-MSCs engrafted into the injured pancreas and promoted pancreatic β-cell function in a mouse model of type 1 diabetes mellitus.

Granulocyte Transfusion during Cord Blood Transplant for Relapsed, Refractory AML Is Associated with Massive CD8+ T Cell Expansion, Significant Cytokine Release Syndrome and Induction...

[British Journal Of Haematology] Researchers reported the safety and tolerability of cord blood transplant recipients receiving granulocyte transfusions, T cell expansion data, immunophenotype, cytokine profiles and clinical response in children with post-transplant relapsed acute leukemia.

A Murine Calvarial Defect Model for the Investigation of the Osteogenic Potential of Newborn Umbilical Cord Mesenchymal Stem Cells in Bone Regeneration

[Plastic And Reconstructive Surgery] Investigators evaluated the efficacy of using tissue-derived human umbilical cord MSC and their osteogenic capabilities in a murine model to improve alveolar cleft repair.

Protecting Human Amnion and Chorion Matrices (HACM) during Processing: Performance Enhancement in a Diabetic Mouse Model and Human Co-Culture System

[Wound Repair And Regeneration] Treatment of diabetic full thickness excisional wounds with HACM, processed with a polyampholyte preservative accentuated the proliferative phase of wound healing that decreased the time necessary to heal wounds.

Summarizing the latest research and reviews since 2009, Umbilical & Placental Cell News, previously known as Cord Blood News, keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cells, placental cells, amniotic fluid and membrane-derived cells, and all their derivatives. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.