Umbilical & Placental Cell News

Umbilical & Placental Cell News is an online resource dedicated to sharing the newest publications, reviews, and news updates in the field of umbilical and placental cell research.

Durable Discontinuation of Systemic Therapy in Patients Affected by Chronic Graft-versus-Host Disease

[Haematologica] Scientists evaluated the factors associated with durable systemic therapy (ST) discontinuation, defined as cessation of all ST for ≥12 months, using data from two prospectively followed cohorts from the chronic graft-versus-host disease Consortium.

Improved Trends in Survival and Engraftment after Single Cord Blood Transplantation for Adult Acute Myeloid Leukemia

[Blood Cancer Journal] To investigate the trends of survival and engraftment after cord blood transplantation (CBT) over the past 22 years, scientists retrospectively evaluated the data of patients with AML in Japan according to the time period of CBT.

Irisin and the Fibronectin Type III Domain-Containing Family: Structure, Signaling and Role in Female Reproduction

[Reproduction] The receptors for irisin are integrins, and it has recently been shown to alter steroidogenesis in ovarian granulosa cells although the effects appear to be species or context specific, and irisin may improve uterine and placental function in women and rodent models.

Derivation of Functional Trophoblast Stem Cells from Primed Human Pluripotent Stem Cells

[Stem Cell Reports] Scientists showed that the trophoblast cells cells resembled placenta- and naive human PSC-derived trophoblast stem cells, based on their transcriptome as well as their in vitro and in vivo differentiation potential.

Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes That Drive Cellular Aging

[Developmental Cell] Investigators found that the epigenetic de-repression unlocked the expression of pregnancy-specific beta-1 glycoprotein genes that exacerbate human mesenchymal progenitor cells aging and serve as potential aging biomarkers.

The Product of BMP-Directed Differentiation Protocols for Human Primed Pluripotent Stem Cells Is Placental Trophoblast and Not Amnion

[Stem Cell Reports] By analyzing transcriptome data from multiple sources, including bulk and single-cell data, investigators showed that the BMP4 procedure generated bona fide trophoblast (TB) with similarities to both placental villous TB and TB generated from TB stem cells.

Acasti Pharma Announces Positive Results for Pharmacokinetic Bridging Study, with Intravenous GTX-104 Meeting All Endpoints

[Acasti Pharma Inc.] Acasti Pharma Inc. announced that the top line results of its pharmacokinetic bridging study with IV GTX-104, the Company’s lead drug candidate for the treatment of Subarachnoid Hemorrhage , met all its planned study endpoints.

Adaptive Immune Defense Prevents Bartonella Persistence upon Trans-placental Transmission

[PLoS Pathogens] Researchers studied an experimental model of Bartonella infection in mice to assess the impact of maternal and newborn immune defense on vertical transmission and bacterial persistence in the offspring, respectively.

Autophagic Flux Inhibition, Apoptosis, and Mitochondrial Dysfunction in Bile Acids-Induced Impairment of Human Placental Trophoblast

[Journal of Cellular Physiology] Researchers evaluated the effect of increased concentration of bile acids on autophagy in trophoblasts in vitro and in vivo.

Aberrant Hypomethylation at Imprinted Differentially Methylated Regions Is Involved in Biparental Placental Mesenchymal Dysplasia

[Clinical Epigenetics] Scientists examined 44 placental specimens from 26 patients with PMD: 19 of these were macroscopically normal and 25 exhibited macroscopic PMD.

SRT1720 Plays a Role in Oxidative Stress and the Senescence of Human Trophoblast HTR8/SVneo Cells Induced by D-galactose through the SIRT1/FOXO3a/ROS Signaling Pathway

[Reproductive Toxicology] Scientists evaluated the effects of D-gal on HTR8/SVneo cells and the mechanisms in vitro. The activity of HTR8/SVneo human trophoblasts decreased in a time- and concentration-dependent manner after exposure to D-gal.

Expression Profiles of Circular RNA in Human Placental Villus and Decidua and Prediction of Drugs for Recurrent Spontaneous Abortion

[American Journal of Reproductive Immunology] Scientists evaluated potential biomarkers and candidate drugs for recurrent spontaneous abortion (RSA) and explored functional circular RNA pathways involved in regulating RSA.

Summarizing the latest research and reviews since 2009, Umbilical & Placental Cell News, previously known as Cord Blood News, keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cells, placental cells, amniotic fluid and membrane-derived cells, and all their derivatives. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.