Umbilical & Placental Cell News

Umbilical & Placental Cell News is an online resource dedicated to sharing the newest publications, reviews, and news updates in the field of umbilical and placental cell research.

RGS2 Promotes Estradiol Biosynthesis by Trophoblasts during Human Pregnancy

[Experimental And Molecular Medicine] Scientists reported that regulator of G-protein signaling 2 (RGS2) affected estradiol levels by regulating aromatase, a rate-limiting enzyme for estradiol biosynthesis, by using human trophoblast-derived JEG-3 cells and human placental villus tissues.

Haemorrhage of Human Fetal Cortex Associated with SARS-CoV-2 Infection

[Brain] SARS-CoV-2 spike protein was sparsely detected within progenitors and neurons of the fetal cortex itself, but was abundant in the choroid plexus of haemorrhagic samples.The virus was also sparsely detected in placenta, amnion, and umbilical cord tissues.

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Diabetic Kidney Disease through the NLRP3 Signaling Pathway

[Stem Cells] Researchers co-cultured podocytes and human umbilical cord-MSCs derived exosomes (Exo) under high glucose and injected MSCs-Exo into diabetic mice, then detected the NLRP3 inflammasome both in vitro and in vivo.

3D Organoid Formation and EVT Differentiation of Various Trophoblastic Cell Lines

[Placenta] Restricted access to first trimester placentae requires alternative cell sources for establishing placental organoids. Scientists tested whether commonly used trophoblastic cell lines, ACH-3P, HTR-8/SVneo, and SWAN-71 were capable of self-organizing into organoids and subsequent extravillous trophoblast differentiation.

Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs

[Tissue Engineering And Regenerative Medicine] The effect of exosomes derived from human amniotic MSCs (hAMSC-Exos) on diabetic wound healing were tested by measuring wound closure rates and immunohistochemical staining of CD31.

Mono(2-Ethylhexyl) Phthalate Induces Transcriptomic Changes in Placental Cells Based on Concentration, Fetal Sex, and Trophoblast Cell Type

[Archives Of Toxicology] HTR-8/SVneo and primary syncytiotrophoblast cells were exposed to three concentrations of mono(2-ethylhexyl) phthalate for 24 hours with DMSO as a vehicle control.

A Combination of Umbilical Cord Mesenchymal Stem Cells and Monosialotetrahexosy 1 Ganglioside Alleviates Neuroinflammation in Traumatic Brain Injury

[Experimental Brain Research] Investigators determined the effect of neural network reconstruction after human umbilical cord MSCs (UMSCs) combined with monosialotetrahexosy 1 ganglioside transplantation, and the effect on the neuro-inflammation and polarization of microglia in a rat model of traumatic brain injury.

Placental Syndromes and Long-term Risk of Hypertension

[Journal Of Human Hypertension] Whether placental impairment and clinical syndromes are causes or consequences of higher blood pressure in women remains unclear. In this review ,the authors address the relationship between blood pressure and maternal health in pregnancy.

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Diabetic Kidney Disease through the NLRP3 Signaling Pathway

[Stem Cells] Researchers co-cultured podocytes and human umbilical cord-MSCs derived exosomes (Exo) under high glucose and injected MSCs-Exo into diabetic mice, then detected the NLRP3 inflammasome both in vitro and in vivo.

Exosomes Derived from Human Adipose Mesenchymal Stem Cells Ameliorate Hepatic Fibrosis by Inhibiting PI3K/Akt/mTOR Pathway and Remodeling Choline Metabolism

[Journal Of Nanobiotechnology] The authors investigated anti-fibrotic efficacy of exosomes derived from human adipose MSCs in vitro and in vivo, and identified important metabolic changes and the detailed mechanism through transcriptomic and metabolomic profiling.

Combining Bone Collagen Material with hUC-MSCs for Applicationto Spina Bifida in a Rabbit Model

[Stem Cell Reviews and Reports] Results showed that the combination of human umbilical cord-MSCs with collagen material had better regeneration effect than collagen material alone, and had no negative impact on the spina bifida models.

Safety and Efficacy of Injection of Human Placenta Mesenchymal Stem Cells Derived Exosomes for Treatment of Complex Perianal Fistula in Non-Crohn’s Cases: Clinical Trial...

[European Journal Of Gastroenterology & Hepatology] Researchers evaluated the safety of MSC-derived exosomes application for complex perianal fistula. Placenta-derived MSCs were cultured and exosomes were isolated using ultracentrifugation.

Summarizing the latest research and reviews since 2009, Umbilical & Placental Cell News, previously known as Cord Blood News, keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cells, placental cells, amniotic fluid and membrane-derived cells, and all their derivatives. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.

spot_img