Umbilical & Placental Cell News

Umbilical & Placental Cell News is an online resource dedicated to sharing the newest publications, reviews, and news updates in the field of umbilical and placental cell research.

Intravenously Transplanted Mesenchymal Stromal Cells: A New Endocrine Reservoir for Cardioprotection

[Stem Cell Research & Therapy] MSCs were isolated from human placenta tissue, and DF-MSCs or Gluc-MSCs were generated by transduced with firefly luciferase/enhanced green fluorescence protein or Gaussia luciferase lactadherin fusion protein.

The Downregulation of miR-22 and miR-372 May Contribute to Gestational Diabetes Mellitus Through Regulating Glucose Metabolism via the PI3K/AKT/GLUT4 Pathway

[Journal of Clinical Laboratory Analysis] Researchers highlighted that miR-22 and miR-372 could improve glucose metabolic disorders in gestational diabetes mellitus (GDM) and might serve as diagnostic biomarkers for GDM as well as promising therapeutic targets for the treatment of this condition.

A Long-Term Anti-inflammation Markedly Alleviated High-Fat Diet-Induced Obesity by Repeated Administrations of Overexpressing IL10 Human Umbilical Cord-Derived Mesenchymal Stromal Cells

[Stem Cell Research & Therapy] Investigators explored whether long-term inhibition of inflammation could successfully alleviate high-fat diet-induced obesity.

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Diffuse Alveolar Hemorrhage Associated with Systemic Lupus Erythematosus in Mice by Promoting M2 Macrophage...

[Immunological Investigations] Human umbilical cord mesenchymal stem cell (HUCMSC)-derived exosomes diminished NOTCH1 expression to accelerate M2 macrophage polarization via delivery of miR-146a-5p, thus alleviating systemic lupus erythematosus-associated diffuse alveolar hemorrhage in mice.

Mice Lacking DCAF2 in Placenta Die at the Gastrulation Stage

[Cell and Tissue Research] To clarify the function of DCAF2 in vivo, scientists used Cre recombinase driven by the Elf5 promoter to generate knockout mouse model that was specifically deleted Dcaf2 in the trophoblast lineage (Elf5-Cre; Dcaf2fl/fl, Dcaf2 cKO).

Mesenchymal Stromal/Stem Cells Spheroid Culture Effect on the Therapeutic Efficacy of These Cells and Their Exosomes: A New Strategy to Overcome Cell Therapy Limitations

[Biomedicine & Pharmacotherapy] Due to the novelty of the field of using 3D culture MSCs-derived exosomes, examination of their properties and the results of their therapeutic application can increase our view of this field.

Aziyo Biologics Appoints Dr. C. Randal Mills as Interim President and CEO

[Aziyo Biologics, Inc.] Aziyo Biologics, Inc., a commercial-stage regenerative medicine company focused on creating the next generation of differentiated products and improving outcomes in patients undergoing surgery, announced Aziyo co-founder C. Randal (Randy) Mills, Ph.D., has been appointed interim president and CEO.

Intravenously Transplanted Mesenchymal Stromal Cells: A New Endocrine Reservoir for Cardioprotection

[Stem Cell Research & Therapy] MSCs were isolated from human placenta tissue, and DF-MSCs or Gluc-MSCs were generated by transduced with firefly luciferase/enhanced green fluorescence protein or Gaussia luciferase lactadherin fusion protein.

Development of Secretome-Based Strategies to Improve Cell Culture Protocols in Tissue Engineering

[Scientific Reports] The effects of three different types of secretome derived from human mesenchymal stem cells were evaluated on cultured skin epithelial cells during 24, 48, 72 and 120 hours to determine the potential of this product to enhance cell proliferation and improve biofabrication strategies for tissue engineering..

Human Umbilical Cord-Derived Mesenchymal Stem Cells Not Only Ameliorate Blood Glucose but Also Protect Vascular Endothelium from Diabetic Damage through a Paracrine Mechanism Mediated...

[Stem Cell Research & Therapy] Scientists conducted in vivo experiment on streptozotocin-induced diabetic rat model to test body weight, fasting blood glucose, serum ICAM-1 and VCAM-1 levels, histopathology and immunohistochemical staining of aorta segments.

Disgraced Italian Surgeon Convicted of Criminal Harm to Stem Cell Patient

[ScienceInsider] A surgeon who just a decade ago was celebrated around the globe as a pioneer in stem cell transplants has been convicted of one count of “causing bodily harm,” a felony, in a Swedish court.

Large-Scale Placenta DNA Methylation Integrated Analysis Reveals Fetal Sex-Specific Differentially Methylated CpG Sites and Regions

[Scientific Reports] Scientists present a mega-analysis of 14 publicly available placenta DNA methylation microarray datasets to identify individual CpGs and regions associated with fetal sex.

Summarizing the latest research and reviews since 2009, Umbilical & Placental Cell News, previously known as Cord Blood News, keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cells, placental cells, amniotic fluid and membrane-derived cells, and all their derivatives. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.

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