Umbilical & Placental Cell News

Umbilical & Placental Cell News is an online resource dedicated to sharing the newest publications, reviews, and news updates in the field of umbilical and placental cell research.

Anemia and Red Blood Cell Transfusion in Women with Placenta Accreta Spectrum: An Analysis of 38,060 Cases

[Scientific Reports] Investigators retrospectively analyzed the prevalence of anemia, transfusion requirements and outcome in women with placenta accreta spectrum. Using data from the German Statistical Office pregnant patients with deliveries hospitalized between January 2012 and December 2021 were included.

Pre-Administration of Human Umbilical Cord Mesenchymal Stem Cells Has Better Therapeutic Efficacy in Rats With D-Galactosamine-Induced Acute Liver Failure

[Umbilical & Placental Cell NewsUmbilical & Placental Cell NewsUmbilical & Placental Cell NewsUmbilical & Placental Cell Ne] The rat model of acute liver failure (ALF) was induced by D-galactosamine, and human umbilical cord (hUC)MSCs were administered via the tail vein 12 hours before or 2 hours after induction. The potential mechanisms of hUCMSCs in treatment of ALF, regulation cell subset and secretion of inflammatory factors, were verified by co-culturing with PBMCs in vitro.

Assessment of the Proteome Profile of Decellularized Human Amniotic Membrane and Its Biocompatibility With Umbilical Cord-Derived Mesenchymal Stem Cells

[Journal Of Biomedical Materials Research Part A] Investigators evaluated the impact of decellularization on the human amniotic membrane based on its proteome profile, physicochemical features, as well as the attachment, viability, and proliferation of umbilical cord-derived MSCs.

Efficacy of Growth Factor Gene–Modified Stem Cells for Motor Function After Spinal Cord Injury in Rodents: A Systematic Review and Meta-Analysis

[Neurosurgical Review] Scientists evaluated the effectiveness of growth factor gene–modified stem cells in restoring motor function after spinal cord injury. Two reviewers searched four databases, including PubMed, Embase, Web of Science, and Scopus, to identify relevant records.

Quantitation and Identification of Microplastics Accumulation in Human Placental Specimens Using Pyrolysis Gas Chromatography Mass Spectrometry

[Toxicological Sciences] Investigators developed methodologies to extract solid materials from human tissue samples by saponification and ultracentrifugation, allowing for highly specific and quantitative analysis of plastics by pyrolysis-gas chromatography and mass spectrometry

miR615-3p Inhibited FBLN1 and Osteogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells by Associated With YTHDF2 in a m6A-miRNA Interaction Manner

[Cell Proliferation] The authors found that FBLN1 promoted osteogenic differentiation of MSCs and MSC-mediated bone regeneration. It was showed that there was an m6A methylation site in 3′UTR of FBLN1 mRNA, and the mutation of the m6A site enhanced the stability of FBLN1 mRNA, subsequently fostering the FBLN1 enhanced osteogenic differentiation of WJCMSCs.

UC Irvine Advances Stem Cell Research with $4 Million CIRM Grant for Shared Resources Lab

[UCI News] The University of California, Irvine (UCI) received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center. The facility will offer essential technologies and training for the development of novel in vitro stem cell-based modeling that will serve researchers across the campus and the state.

Identification of Critical Process Parameters for Expansion of Clinical Grade Human Wharton’s Jelly-Derived Mesenchymal Stromal Cells in Stirred-Tank Bioreactors

[Biotechnology Journal] The feasibility of transitioning was evaluated from an established Wharton's jelly MSCs 2D production strategy to a new one with stirred-tank bioreactors. Experimental conditions included four GMP-compliant xeno- and serum-free media screened in 2D conditions and two GMP-grade microcarriers assessed in 0.25 L-STRs using serum-containing media.

The Regulated Cell Death at the Maternal-Fetal Interface: Beneficial or Detrimental?

[Cell Death Discovery] Investigators summarized the apoptosis, necroptosis and autophagy play both promoting and inhibiting roles in the differentiation, invasion of trophoblast, remodeling of the uterine spiral artery and decidualization, whereas ferroptosis and pyroptosis have adverse effects.

Dynamic and Distinct Histone Modifications Facilitate Human Trophoblast Lineage Differentiation

[Scientific Reports] Through comprehensive mapping of H3K4me3, H3K27me3, H3K9me3, and H3K27ac loci during the differentiation of trophoblast stem cells into syncytiotrophoblasts and extravillous trophoblasts, the authors revealed dynamic reconfiguration in H3K4me3 and H3K27ac patterns that establish an epigenetic landscape conducive to proper trophoblast lineage differentiation.

Placental Transfer Dynamics and Durability of Maternal COVID-19 Vaccine-Induced Antibodies in Infants

[iScience] Scientists evaluated anti-COVID antibody IgG subclass, Fc-receptor binding profile, and activity against wild-type Spike and RBD plus five variants of concern in 153 serum samples from 100 infants.

Targeting Senescent Alveolar Epithelial Cells Using Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles To Treat Pulmonary Fibrosis

[ACS Nano] Scientists constructed CD38 antigen receptor membrane-modified MSC-extracellular vesicles by transfecting MSCs with a lentivirus loaded with a CD38 antigen receptor–CD8 transmembrane fragment fusion plasmid to target AEC2s and alleviate pulmonary fibrosis.

Summarizing the latest research and reviews since 2009, Umbilical & Placental Cell News, previously known as Cord Blood News, keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cells, placental cells, amniotic fluid and membrane-derived cells, and all their derivatives. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.