Umbilical & Placental Cell News

Umbilical & Placental Cell News is an online resource dedicated to sharing the newest publications, reviews, and news updates in the field of umbilical and placental cell research.

Acasti Pharma Announces Positive Results for Pharmacokinetic Bridging Study, with Intravenous GTX-104 Meeting All Endpoints

[Acasti Pharma Inc.] Acasti Pharma Inc. announced that the top line results of its pharmacokinetic bridging study with IV GTX-104, the Company’s lead drug candidate for the treatment of Subarachnoid Hemorrhage , met all its planned study endpoints.

Adaptive Immune Defense Prevents Bartonella Persistence upon Trans-placental Transmission

[PLoS Pathogens] Researchers studied an experimental model of Bartonella infection in mice to assess the impact of maternal and newborn immune defense on vertical transmission and bacterial persistence in the offspring, respectively.

Autophagic Flux Inhibition, Apoptosis, and Mitochondrial Dysfunction in Bile Acids-Induced Impairment of Human Placental Trophoblast

[Journal of Cellular Physiology] Researchers evaluated the effect of increased concentration of bile acids on autophagy in trophoblasts in vitro and in vivo.

Aberrant Hypomethylation at Imprinted Differentially Methylated Regions Is Involved in Biparental Placental Mesenchymal Dysplasia

[Clinical Epigenetics] Scientists examined 44 placental specimens from 26 patients with PMD: 19 of these were macroscopically normal and 25 exhibited macroscopic PMD.

SRT1720 Plays a Role in Oxidative Stress and the Senescence of Human Trophoblast HTR8/SVneo Cells Induced by D-galactose through the SIRT1/FOXO3a/ROS Signaling Pathway

[Reproductive Toxicology] Scientists evaluated the effects of D-gal on HTR8/SVneo cells and the mechanisms in vitro. The activity of HTR8/SVneo human trophoblasts decreased in a time- and concentration-dependent manner after exposure to D-gal.

Expression Profiles of Circular RNA in Human Placental Villus and Decidua and Prediction of Drugs for Recurrent Spontaneous Abortion

[American Journal of Reproductive Immunology] Scientists evaluated potential biomarkers and candidate drugs for recurrent spontaneous abortion (RSA) and explored functional circular RNA pathways involved in regulating RSA.

Effect of Umbilical Cord Mesenchymal Stem Cell Transplantation under LIFPUS Pretreatment on Thyroid Function in EAT Rats

[Current Stem Cell Research & Therapy] Scientists showed that LIFPUS could effectively stimulate hUCMSCs in vitro to achieve the most optimal proliferative and secretory activity.

Allogenic Umbilical Cord Blood-Mesenchymal Stem Cells Are More Effective than Antibiotics in Alleviating Subclinical Mastitis in Dairy Cows

[Theriogenology] Researchers isolated, in vitro cultured, and characterized the umbilical cord-derived mesenchymal stem cells (UCB-MSCs) as well as UCB-MSC-extracellular vesicles.

WNT and NOTCH Signaling in Human Trophoblast Development and Differentiation

[Cellular and Molecular Life Sciences] Research discuss Wingless (WNT) and NOTCH signaling, two pathways that play pivotal roles in human placenta and trophoblast development.

University of Nottingham Partnership Part of £20M Investment in New Blood and Transplant Units

[The University of Nottingham] The University of Nottingham is one of five research units across blood, organ, plasma, and stem cells launched by NHS Blood and Transplant.

Overexpression of lncRNA HCP5 in Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promoted the Proliferation and Inhibited the Apoptosis of Ovarian Granulosa Cells via...

[Endocrine Journal] HucMSC-derived exosomes promoted the proliferation of ovarian granulosa cells and oestrogen receptor alpha 1 expression and inhibited cell apoptosis.

A Genome-Wide CRISPR-Cas9 Knockout Screen Identifies Essential and Growth-Restricting Genes in Human Trophoblast Stem Cells

[Nature Communications] The authors utilized a genome-wide CRISPR-Cas9 knockout screen to comprehensively identify essential and growth-restricting genes in human trophoblast stem cells.

Summarizing the latest research and reviews since 2009, Umbilical & Placental Cell News, previously known as Cord Blood News, keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cells, placental cells, amniotic fluid and membrane-derived cells, and all their derivatives. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.