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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Urolithin A Activates Mitophagy via the AMPK-mTOR Axis and Modulates the Gut-Ceramide Axis to Ameliorate Cardiac Remodeling in HFpEF
[Experimental & Molecular Medicine] Scientists investigated whether urolithin A (UA) , a gut microbiome-derived mitophagy-activating compound, can ameliorate heart failure with preserved ejection fraction (HFpEF). In vitro and in vivo experiments, together with multi-omics analyses, showed that UA alleviated diastolic dysfunction, cardiac hypertrophy, and fibrosis in HFpEF mice.
Restoring Anisotropy after Myocardial Injury: Strategies to Align Transplanted Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes
[Experimental & Molecular Medicine] This review focuses on cardiomyocyte alignment as a critical design requirement for improving electrophysiological and regenerative outcomes in hiPSC-cardiomyocyte based cardiac cell therapy. They summarize bioengineering strategies that impose or preserve alignments, including topographical guidance, mechanical anisotropy, and electrical conditioning.
PRDM16 Modulates Aspects of Cell Cycle Dynamics and Maturation in Human iPSC-Derived Cardiomyocytes
[Stem Cell Reports] Scientists identifed PRDM16 as a regulator that influences the balance between proliferation and maturation in human iPSC-derived cardiomyocytes (hiPSC-CMs).
Cardiomyocyte-Specific Depletion of Integrin α3 Preserves Cardiac Function after Myocardial Infarction
[Basic Research in Cardiology] To evaluate the role of Integrin α3 (ITGA3) in vivo, scientists generated a mouse line with cardiomyocyte-specific ITGA3 depletion (ITGA3 KO). ITGA3 KO mice were characterized under baseline conditions and after permanent LAD ligation by echocardiography.
Multiscale Analysis and Functional Validation of the Cellular and Genetic Determinants of Skeletal Disease
[Nature Genetics] Researchers exploited the value of cross-species analysis and developed single-cell methodologies in skeletal tissues to define the critical endosteal compartment that regulates bone turnover.
The Formin Fhod3 Is Required for Sarcomere Reassembly after Mitosis in Postnatal Cardiomyocytes
[Cellular and Molecular Life Sciences] Investigators examined the effects of Fhod3 depletion in primary cultured cardiomyocytes derived from Fhod3flox neonates. Long-range time-lapse imaging revealed that Fhod3 depletion around birth using muscle creatine kinase-Cre caused sarcomere disruption only in cells that had undergone mitosis.
An H3K18la-ALKBH5-Runx2-LDHA Positive Feedback Loop Promotes Vascular Calcification in the Osteogenic Phenotypic Transition of Vascular Smooth Muscle Cells
[Cellular Signalling] Scientists confirmed that histone H3 lysine 18 lactylation (H3K18la) is abnormally elevated in osteogenic vascular smooth muscle cells. They demonstrated that H3K18la directly binds to the promoter region of AlkB homolog 5 (ALKBH5) and positively regulates its transcription.
USP18 Regulates Skeletal Muscle Regeneration Independently of Its deISGylation Activity
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] USP18 acts as a context-dependent regulator of muscle regeneration independent of its deISGylation function. The authors identified USP18 as a dual modulator of myogenesis and highlighted its potential as a therapeutic target in inflammatory muscle disease.
Epicrispr Completes Enrollment and Dose Escalation in First-in-Human EPI-321 Trial for FSHD
[Epicrispr Biotechnologies] Epicrispr Biotechnologies announced the completion of enrollment and dosing in the dose-escalation portion of its first-in-human clinical trial evaluating EPI-321 for facioscapulohumeral muscular dystrophy.
Dr. Tim Allerton Receives $3.6M NIH Grant for Heart Failure Research
[Bioengineer] Dr. Tim Allerton has recently been awarded a highly competitive National Institutes of Health (NIH) grant. This funding will support pioneering research into heart failure with preserved ejection fraction, a rapidly growing and complex form of heart failure affecting millions of people worldwide.
Stiffness-Induced Impairment of GLUT4 Trafficking in Adult Cardiomyocytes
[Cell Reports] Researchers observed that human and rat adult cardiomyocytes cultured on stiff surfaces develop blunted insulin-mediated glucose uptake, associated with intracellular aggregation of the high-affinity glucose transporter GLUT4 within the microtubule network, and with impaired contractility.
Kbtbd13 Knockdown Restores Muscle Function in a Clinically Relevant Mouse Model of Nemaline Myopathy Type 6
[Science Translational Medicine] Scientists showed that Kelch repeat and BTB domain–containing 13 (KBTBD13) knockdown restores muscle function and reverses disease features in a clinically relevant mouse model of nemaline myopathy type 6, highlighting a promising therapeutic strategy.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
