Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

VGLL4-TEAD1 Promotes Vascular Smooth Muscle Cell Differentiation from Human Pluripotent Stem Cells via TET2

[Journal of Molecular and Cellular Cardiology] Using microarray profiling, investigators found that the Hippo pathway components vestigial-like family member 4 (VGLL4) and TEA domain transcription factor 1 (TEAD1) were upregulated during vascular smooth muscle cell differentiation from H1 ESCs.

Co-Culture Models of Endothelial Cells, Macrophages, and Vascular Smooth Muscle Cells for the Study of the Natural History of Atherosclerosis

[Plos One] Scientists presented a fast, affordable, and reproducible three-cell co-culture system that could represent the different cellular mechanisms of atherosclerosis, extending from atherogenesis to pathological intimal thickening.

Monoamine Oxidase A-dependent ROS Formation Modulates Human Cardiomyocyte Differentiation through AKT and WNT Activation

[Basic Research In Cardiology] Scientists investigated whether reactive oxygen species (ROS) produced by the mitochondrial flavoenzyme monoamine oxidase A played a role in cardiomyocyte differentiation from human-induced pluripotent stem cells.

A Phenotypic Screen of Marfan Syndrome iPSC-Derived Vascular Smooth Muscle Cells Uncovers GSK3β as a New Target

[Stem Cell Reports] Scientists described a medium-throughput, unbiased small molecule screen to identify novel disease mechanisms and therapeutic targets using induced pluripotent stem cell (iPSC) technology.

Single-Cell Transcriptomics Reveal Extracellular Vesicles Secretion with a Cardiomyocyte Proteostasis Signature during Pathological Remodeling

[Communications Biology] Functional enrichment analysis pointed to an involvement of extracellular vesicle-related processes in the hearts of β-catΔex3 mice. Human induced pluripotent stem cells-derived cardiomyocytes subjected to pharmacological Wnt activation recapitulated the increased expression of exosomal markers, CRYAB accumulation, and increased PQC signaling.

Protective Effect of Urotensin II Receptor Antagonist Urantide and Exercise Training on Doxorubicin-Induced Cardiotoxicity

[Scientific Reports] In vitro and in vivo assessments were performed using Doxorubicin (DOX)-treated H9C2 cells and rats. It was found that the Urotensin II receptor (UT) antagonist, Urantide, and exercise training improved DOX-induced cardiac insufficiency and cardiomyocyte apoptosis, improved the structural disorder of myocardial fibers, and inhibited DOX-induced myocardial fibrosis.

Caloric Restriction Delays Age-Related Muscle Atrophy by Inhibiting 11β−HSD1 to Promote the Differentiation of Muscle Stem Cells

[Frontiers In Medicine] Researchers used a calorie restriction (CR) model of elderly mice with muscle-specific 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) knockout mice and 11β-HSD1 overexpression mice to confirm that CR could delay muscle aging by inhibiting 11β-HSD1. The ability of self-proliferation and differentiation into muscle fibers of these mouse muscle stem cells was observed in vitro.

Tensile Loaded Tissue Engineered Human Tendon Constructs Stimulate Myotube Formation

[Tissue Engineering Part A] Investigators tested whether factors released by 3D-engineered human tendon constructs in response to uniaxial tensile loading could stimulate the proliferation and differentiation of human-derived myogenic cells.

A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14

[American Journal Of Respiratory Cell And Molecular Biology] Scientists established that the activation of the bitter taste receptor, TAS2R14, in human airway smooth muscle cells promoted relaxation through F-actin severing.

Co-culture Models of Endothelial Cells, Macrophages, and Vascular Smooth Muscle Cells for the Study of the Natural History of Atherosclerosis

[Plos One] Investigators presented a fast, affordable, and reproducible three-cell co-culture system that could represent the different cellular mechanisms of atherosclerosis, extending from atherogenesis to pathological intimal thickening.

GATA6 Triggers Fibroblast Activation and Tracheal Fibrosis through the Wnt/β-Catenin Pathway

[Cellular Signalling] Researchers investigated the potential role of GATA6 as a novel regulator of tracheal fibrosis. It was found that GATA6 and α-smooth muscle actin (α-SMA) were obviously increased in tracheal fibrotic granulations and in TGFβ1-treated primary tracheal fibroblasts.

Metabolism-Based Cardiomyocytes Production for Regenerative Therapy

[Journal Of Molecular And Cellular Cardiology] The authors describe the metabolic programs in human pluripotent stem cells (hPSCs) and the metabolic regulation in hPSC-cardiomyocyte production for cardiac regenerative therapy.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.

spot_img