[Secretome Therapeutics (Business Wire)] Secretome Therapeutics, a clinical-stage biotechnology company developing novel therapies derived from neonatal cardiac progenitor cells (nCPC), today announced the closing of a $30 million Series A financing from RA Capital Management, LP (“RA Capital”), a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies. RA Capital was the sole investor in the financing.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed a screening platform using hiPSC–derived cardiomyocytes to identify human cardiotropic lipid nanoparticles (LNPs). By screening a chemically diverse LNP library, they identified a lead LNP, 18:1 TAP10, with potent human cardiac transfection capability.

[Cell Reports] Scientists investigated the impact of maternal hyperglycemia on cardiac development using a diabetic pregnancy mouse model and pluripotent stem cell-derived cardiomyocytes.

[Circulation Research] The authors investigated hypothesized roles and mechanisms of cell type–specific, selective activation of different vascular NADPH oxidase (NOX) isoforms in obesity and metabolic syndrome.

[Journal of Clinical Investigation] Investigators examined the consequences of Jagged2 JAGGED2 (JAG2) deficiency and modeled pathogenic JAG2 variants in vitro and in vivo, the latter in mouse and fly models and with particular attention to the muscle stem cell-muscle endothelial cell niche.

[Science Advances] Scientists used a flow cytometry approach coupled with scRNAseq to determine the muscle senescent cell identity and transcriptional landscape during skeletal muscle recovery following disuse atrophy.

[Cell Stem Cell] Researchers identified a smooth muscle-derived transient progenitor cell population, marked by CD34 expression, which emerges after artery injury.

[Biochemical Society Transactions] Investigators highlight the role of heterogeneous nuclear ribonucleoprotein K (hnRNPK) in myogenic differentiation, gene expression control, signaling pathway cross-talk, and skeletal muscle development.

[Experimental & Molecular Medicine] Aligning therapeutic action with the intrinsic biology of myocardial healing provides a rational pathway toward more effective, durable, and biologically informed strategies for cardiac repair and, where biology permits, regeneration.

[Experimental & Molecular Medicine] Scientists investigated the contribution of EHMT2 to vascular smooth muscle cell (VSMC) proliferation, migration and neointima formation following vascular injury using carotid artery injury models and in vitro VSMC studies.

[Cell] Researchers used a combination of electron and fluorescence microscopy to demonstrate that nuclear envelope budding events occur following myoblast differentiation into myotubes and concomitant with the expression of extremely long muscle-specific transcripts.

[Science] Investigators found that microtubule dynamics could act as a toggle to direct cardiomyocyte growth. Increasing microtubule stability drove cellular widening, concomitant with redirecting mRNA export and translation along the width of the cell and reinforcement of the intercalated disc.