Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

The Mechanism of the Imbalance Between Proliferation and Ferroptosis in Pulmonary Artery Smooth Muscle Cells Based on the Activation of SLC7A11

[European Journal of Pharmacology] SLC7A11 was up-regulated in Sugen5416/hypoxia-induced pulmonary arterial hypertension (PAH) rats and patients with PAH. Moreover, solute carrier family 7 member 11 (SLC7A11) inhibited ferroptosis and promoted proliferation by overexpressing SLC7A11 in pulmonary artery smooth muscle cells.

Salvianolic Acid A From Danhong Injection Induces Vasorelaxation by Regulating L-Type Calcium Channel in Isolated Mouse Arteries

[Journal of Ethnopharmacology] Scientists determined the vasodilating substances of Danhong injection and explained its molecular mechanism of vasodilation. With molecular biology experiments, it was verified that the relevant mechanisms were closely related to calcium-mediated vasoconstriction in smooth muscle cells.

Epigenetic Reactivation of Transcriptional Programs Orchestrating Fetal Lung Development in Human Pulmonary Hypertension

[Science Translational Medicine] RNA sequencing in pulmonary artery fibroblasts (FBs) from adult human pulmonary arterial hypertension (PAH) and control lungs revealed 2460 differentially transcribed genes. Silencing of TBX4, TBX5, SOX9, or E1A-associated protein P300 by RNA interference or small-molecule compounds regressed PAH phenotypes and mesenchymal signatures in arterial FBs and smooth muscle cells.

FibroGen Announces Completion of Patient Enrollment in LELANTOS-2, a Phase III Clinical Study of Pamrevlumab in Duchenne Muscular Dystrophy

[FibroGen, Inc.] FibroGen, Inc. announced completion of patient enrollment for LELANTOS-2, a Phase 3 clinical study of pamrevlumab in patients with ambulatory Duchenne muscular dystrophy.

Antioxidant Effects of Bis-Indole Alkaloid Indigo and Related Signaling Pathways in the Experimental Model of Duchenne Muscular Dystrophy

[Cell Stress & Chaperones] Investigators evaluated the potential role of the indigo on oxidative stress and related signaling pathways in primary skeletal muscle cell cultures and in the diaphragm muscle from mdx mice.

Active Force Generation Contributes to the Complexity of Spontaneous Activity and to the Response to Stretch of Murine Cardiomyocyte Cultures

[Journal of Physiology-London] Using stretchable microelectrode arrays, we assessed the effects of the myosin inhibitor blebbistatin and the nonselective stretch-activated channel blocker streptomycin on beating variability and on the response of neonatal or fetal murine ventricular cell cultures against deformation.

Global O-GlcNAcylation Changes Impact Desmin Phosphorylation and Its Partition Toward Cytoskeleton in C2C12 Skeletal Muscle Cells Differentiated Into Myotubes

[Scientific Reports] In a model of C2C12 myotubes, researchers modulated the global O-GlcNAcylation level, and they determined whether the expression, the post-translational modifications and the partition of desmin toward insoluble material or cytoskeleton were impacted or not.

RNA-Binding Proteins Direct Myogenic Cell Fate Decisions

[Stem Cells and Regenerative Medicine] Single-cell RNA-sequencing of regenerating Mus musculus skeletal muscle revealed that RNA-binding protein expression, including the expression of many neuromuscular disease-associated RBPs, was temporally regulated in skeletal muscle stem cells and correlated with specific stages of myogenic differentiation.

Silencing METTL3 Stabilizes Atherosclerotic Plaques by Regulating the Phenotypic Transformation of Vascular Smooth Muscle Cells via the miR-375-3p/PDK1 Axis

[Cardiovascular Drugs and Therapy] Scientists investigated the mechanism of methyltransferase-like 3 (METTL3) in atherosclerosis plaques via modulating the phenotypic transformation of vascular smooth muscle cells.

Synthetic Growth Hormone-Releasing Hormone Agonist Ameliorates the Myocardial Pathophysiology Characteristic of HFpEF

[Cardiovascular Research] Researchers demonstrated that the activation of the growth hormone-releasing hormone receptor signaling pathway within the myocardium both prevented and reversed diastolic dysfunction and pathophysiologic features consistent with heart failure with preserved ejection fraction (HFpEF).

Cardiomyocyte Death in Sepsis: Mechanisms and Regulation

[Molecular Medicine Reports] Authors review advances in understanding of sepsis‑induced cardiomyocyte death pathways, including apoptosis, necroptosis, mitochondria‑mediated necrosis, pyroptosis, ferroptosis and autophagy.

Future Scope and Challenges for Congestive Heart Failure: Moving Towards Development of Pharmacotherapy

[Canadian Journal of Physiology and Pharmacology] Scientists discuss different mechanisms involving both cardiomyocytes and non-myocyte (extracellular matrix) alterations for the transition of cardiac hypertrophy to heart failure as well as for the progression of heart failure.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.