Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Suppression of Smooth Muscle Cell Inflammation by Myocardin-Related Transcription Factors Involves Inactivation of TANK-Binding Kinase 1

[Scientific Reports] Researchers tested if myocardin-related transcription factors suppressed inflammation also by targeting cGAS-STING signaling. Interrogation of a transcriptomic dataset where myocardin was overexpressed using a panel of 56 cGAS-STING cytokines showed the panel to be repressed.

TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure

[Circulation] Male and female control or tripartite motif containing 35 (TRIM35) overexpression adolescent and adult transgenic mice were used for all in vivo experiments.

Endothelial Cell Signature in Muscle Stem Cells Validated by VEGFA-FLT1-AKT1 Axis Promoting Survival of Muscle Stem Cell

[eLife] Researchers used several computational analyses including single-cell RNAseq to show that muscle stem cells expressed low levels of canonical endothelial cell markers in mice.

LncRNA DCRT Protects against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1

[Circulation] The dilated cardiomyopathy repressive transcript (DCRT) knockout mice and DCRT knockout cells were developed using CRISPR-Cas9 technology.

Tipifarnib Reduces Extracellular Vesicles and Protects from Heart Failure

[Circulation Research] The authors investigated the role of circulating exosomes during cardiac dysfunction and remodeling in a mouse transverse aortic constriction model of heart failure.

Setdb1 Protects Genome Integrity in Murine Muscle Stem Cells to Allow for Regenerative Myogenesis and Inflammation

[Developmental Cell] Scientists showed that Setdb1 expression by adult muscle stem cells was required for skeletal muscle regeneration.

Circ_0008571 Modulates the Phenotype of Vascular Smooth Muscle Cells by Targeting miR-145-5p in Intracranial Aneurysms

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] circRNA sequencing was used to identify circRNAs from human intracranial aneurysm tissues. To determine the function of circ_0008571, Transwell, wound healing, and cell proliferation assays were conducted.

Network-Based Prioritization and Validation of Regulators of Vascular Smooth Muscle Cell Proliferation in Disease

[Nature Cardiovascular Research] Investigators detected widespread activation of enhancers at disease-relevant loci in proliferation-predisposed vascular smooth muscle cells.

Calcium Signaling from Sarcoplasmic Reticulum and Mitochondria Contact Sites in Acute Myocardial Infarction

[Journal of Translational Medicine] The authors summarize and update the knowledge about the roles of these organelles in acute myocardial infarction from a calcium ion signaling point of view.

FDA Approves First Generics of Heart Failure Combo Drug Entresto

[Medical Professionals Reference] The FDA has approved the first generics of Entresto® tablets. The combination of sacubitril and valsartan is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure.

IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts

[Circulation] Cardiomyocyte-specific inositol-requiring enzyme 1α (IRE1α) knockout and overexpression mouse models were generated to explore its function in vivo.

Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling

[Circulation Research] β2-adrenergic receptor signaling mechanisms were studied in isolated neonatal rat ventricular myocytes and adult mouse ventricular myocytes using live cell imaging and Western blotting methods.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.