PDGF-PDGFR Network Differentially Regulates, Myogenic Cell Fate, Migration, Proliferation, and Cell Cycle Progression

The authors explored the PDGF-PDGFR gene expression changes and their involvement in skeletal muscle myogenesis and myogenic fate.
[Cellular Signalling]
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Spermidine Inhibits Vascular Calcification in Chronic Kidney Disease through Modulation of SIRT1 Signaling Pathway

Alizarin red staining and quantification of calcium content showed that spermidine treatment markedly reduced mineral deposition in both rat and human vascular smooth muscle cells (VSMCs) under osteogenic conditions.
[Aging Cell]
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Puerarin Protects Cardiomyocytes from Ischemia–Reperfusion Injury by Upregulating LncRNA ANRIL and Inhibiting Autophagy

Researchers analyzed the roles of puerarin and LncRNA ANRIL in myocardial ischemia–reperfusion injury. After cell transfection, the effects of overexpressed and knockdown of ANRIL on cardiomyocytes and H/R-injured cardiomyocytes were examined by rescue experiments.
[Cell and Tissue Research]
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Decreased YAP Activity Reduces Proliferative Ability in Human Induced Pluripotent Stem Cell of Duchenne Muscular Dystrophy Derived Cardiomyocytes

Scientists investigated yes-associated protein (YAP) activity using disease-specific induced pluripotent stem cell derived cardiomyocytes in Duchenne muscular dystrophy.
[Scientific Reports]
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Skeletal Muscle Fibers Count on Nuclear Numbers for Growth

The authors review recent advances that elucidate the relationship between myonuclear numbers and establishment of myofiber size, and discuss how this new information refines our understanding of the concept of myonuclear domains, the cytoplasmic volumes that each resident myonucleus can support.
[Seminars in Cell & Developmental Biology]
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Identification of Dynamic RNA-Binding Proteins Uncovers a Cpeb4-Controlled Regulatory Cascade during Pathological Cell Growth of Cardiomyocytes

Scientists identified mRNAs bound to and regulated by Cpeb4 in cardiomyocytes. Cpeb4 regulated cardiac remodeling by differential expression of transcription factors.
[Cell Reports]
Riechert, E., Kmietczyk, V., Stein, F., Schwarzl, T., Sekaran, T., Jürgensen, L., Kamuf-Schenk, V., Varma, E., Hofmann, C., Rettel, M., Gür, K., Ölschläger, J., Kühl, F., Martin, J., Ramirez-Pedraza, M., Fernandez, M., Doroudgar, S., Méndez, R., Katus, H. A., … Völkers, M. (2021). Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes. Cell Reports, 35(6). https://doi.org/10.1016/j.celrep.2021.109100 Cite
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Mitofusin-2 Stabilizes Adherens Junctions and Suppresses Endothelial Inflammation via Modulation of β-Catenin Signaling

Using three-dimensional structured illumination microscopy, scientists observed that the mitochondrial protein Mitofusin-2 (Mfn2) co-localized at the plasma membrane with VE-cadherin and β-catenin in endothelial cells during homeostasis.
[Nature Communications]
Kim, Y.-M., Krantz, S., Jambusaria, A., Toth, P. T., Moon, H.-G., Gunarathna, I., Park, G. Y., & Rehman, J. (2021). Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling. Nature Communications, 12(1), 2736. https://doi.org/10.1038/s41467-021-23047-6 Cite
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Persistent NF-κB Activation in Muscle Stem Cells Induces Proliferation-Independent Telomere Shortening

Researchers demonstrated that the distinct early telomere shortening of diseased muscle stem cell in both mice and young Duchenne muscular dystrophy patients was associated with aberrant NF-κB activation.
[Cell Reports]
Tichy, E. D., Ma, N., Sidibe, D., Loro, E., Kocan, J., Chen, D. Z., Khurana, T. S., Hasty, P., & Mourkioti, F. (2021). Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening. Cell Reports, 35(6). https://doi.org/10.1016/j.celrep.2021.109098 Cite
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Targeting Inflammation in Atherosclerosis — from Experimental Insights to the Clinic

Scientists consider a gamut of attractive possibilities for modifying inflammation in atherosclerosis, including targeting pivotal inflammatory pathways such as the inflammasomes, inhibiting cytokines, manipulating adaptive immunity and promoting pro-resolution mechanisms.
[Nature Reviews Drug Discovery]
Soehnlein, O., & Libby, P. (2021). Targeting inflammation in atherosclerosis — from experimental insights to the clinic. Nature Reviews Drug Discovery, 1–22. https://doi.org/10.1038/s41573-021-00198-1 Cite
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Three-Dimensional Tissue-Engineered Human Skeletal Muscle Model of Pompe Disease

Researchers reported a three-dimensional primary human skeletal muscle model of infantile-onset Pompe disease that recapitulated hallmark pathological features including reduced GAA enzyme activity, elevated glycogen content and lysosome abundance, and increased sensitivity of muscle contractile function to metabolic stress.
[Communications Biology]
Wang, J., Zhou, C. J., Khodabukus, A., Tran, S., Han, S.-O., Carlson, A. L., Madden, L., Kishnani, P. S., Koeberl, D. D., & Bursac, N. (2021). Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-021-02059-4 Cite
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The Effects of Exercise Training on Kinesin and GAP-43 Expression in Skeletal Muscle Fibers of STZ-Induced Diabetic Rats

Scientists investigated the beneficial effects of endurance training on growth Associated Protein 43 (GAP-43) and Kinesin Family Member 5B (KIF5B) expression in gastrocnemius muscle of streptozotocin – induced diabetic rats.
[Scientific Reports]
Rahmati, M., & Taherabadi, S. J. (2021). The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats. Scientific Reports, 11(1), 9535. https://doi.org/10.1038/s41598-021-89106-6 Cite
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