Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Cell-Free DNA as a Potential Biomarker of Differentiation and Toxicity in Cardiac Organoids

[Elife] The authors presented a scalable method for high-throughput screening of cell-free DNA from cardiac organoids.

Exercise Metabolism and Adaptation in Skeletal Muscle

[Nature Reviews molecular cell biology] The authors provide a contemporary view of the metabolic flexibility and functional plasticity of skeletal muscle in response to exercise.

SARS-CoV-2 Induces Cardiomyocyte Apoptosis and Inflammation but Can Be Ameliorated by ACE Inhibitor Captopril

[Antiviral Research] Scientists found that SARS-CoV-2 could infect cardiomyocytes and produce infectious progeny viruses in human pluripotent stem cell-derived cardiomyocyte-like cells.

Cardiomyocyte Nuclear Remodeling After Mechanical Unloading

[American Journal Of Physiology-Heart And Circulatory Physiology] Researchers studied whether changes in DNA content with mechanical unloading occurred independent of cardiomyocyte proliferation by comparing human subjects undergoing left ventricular assist device implantation or primary transplantation.

Slo1 Deficiency Impaired Skeletal Muscle Regeneration and Slow-Twitch Fibre Formation

[Journal Of Cachexia Sarcopenia And Muscle] To investigate the involvement of genes in the regulation of muscle dysfunction induced by Slo1 deletion, RNA-seq analysis was performed in primary myoblasts.

Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart

[eLife] Researchers investigated the role of senescence in regulating inflammation, fibrosis, and arrhythmogenesis in young and aged infarcted rabbits.

Non-Canonical Telomere Protection Role of FOXO3a of Human Skeletal Muscle Cells Regulated by the TRF2-Redox Axis

[Communications Biology] Scientists showed in transformed fibroblasts and myotubes that the telomere properties of FOXO3a were dependent on the C-terminal segment of its CR2 domain but independent of its Forkhead DNA binding domain and of its CR3 transactivation domain.

miR-136-5p/FZD4 Axis Is Critical for Wnt Signaling-Mediated Myogenesis and Skeletal Muscle Regeneration

[Journal Of Cellular Physiology] Investigators found that miR-136-5p was significantly upregulated during the proliferation and differentiation of C2C12 cells.

Bioinspired PLCL/Elastin Nanofibrous Vascular Tissue Engineering Scaffold Enhances Endothelial Cells and Inhibits Smooth Muscle Cells

[Biomacromolecules] Cell culture experiments showed that a novel composite fiber membrane had high cell viability, promoting the proliferation and adhesion of human umbilical vein endothelial cells and inducing a contractile phenotype in human umbilical artery smooth muscle cells.

A High-Throughput 3D Cantilever Array To Model Airway Smooth Muscle Hypercontractility in Asthma Scilightfeatured

[APL Bioengineering] Using DEFLCT, researchers exposed primary human airway smooth muscle cell-derived microtissues to a panel of six inflammatory cytokines present in the asthmatic niche, identifying TGF-β1 and IL-13 as inducers of a hypercontractile phenotype.

MasR and pGCA Receptor Activation Protects Primary Vascular Smooth Muscle Cells and Endothelial Cells Against Oxidative Stress via Inhibition of Intracellular Calcium

[Journal Of Cellular Biochemistry] Investigators determined the effect of co-activation of MasR and particulate guanylate cyclase receptor (pGCA) pathways by synthesizing novel peptides in oxidative stress-induced vascular smooth muscle cells and endothelial cells.

Lexicon Announces FDA Approval of InpefaTM (Sotagliflozin) for Treatment of Heart Failure

[Lexicon Pharmaceuticals, Inc.] Lexicon Pharmaceuticals, Inc. announced that the US FDA approved INPEFA, a once-daily oral tablet to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in adults with heart failure, type 2 diabetes mellitus, chronic kidney disease, and other cardiovascular risk factors.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.