Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Modifying miRs for Effective Reprogramming of Fibroblasts to Cardiomyocytes

[Molecular Therapy - Nucleic Acids] Researchers reported enhanced efficacy of our miR reprogramming cocktail miR combo, miR-1, miR-133a, miR-208a and miR-499, via RNA-sensing receptor stimulation.

MBNL1 Regulates Programmed Postnatal Switching between Regenerative and Differentiated Cardiac States

[Circulation] Muscleblind-like 1 (MBNL1) gain- and loss-of-function mouse models were studied at several developmental time points and in surgical models of heart regeneration.

Human Beta Defensin 3 Knockdown Inhibits the Proliferation and Migration of Airway Smooth Muscle Cells through Regulating the PI3K/AKT Signaling Pathway

[Molecular Immunology] Scientists investigated the functions of human β defensin-3 in asthma progression. Blood samples from asthmatic and healthy children were collected.

Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond

[Hypertension] The authors summarize the latest understanding of the molecular mechanisms by which smooth muscle cell-mineralocorticoid receptor contributes to regulation of vasomotor function and blood pressure , and more.

SNUPN Deficiency Causes a Recessive Muscular Dystrophy Due to RNA Mis-Splicing and ECM Dysregulation

[Nature Communications] The authors demonstrated that mutant SPN1 failed to oligomerize leading to cytoplasmic aggregation in patients’ primary fibroblasts and CRISPR/Cas9-mediated mutant cell lines.

Flvcr1a Deficiency Promotes Heme-Based Energy Metabolism Dysfunction in Skeletal Muscle

[Cell Reports] Scientists generated a skeletal-muscle-specific feline leukemia virus subgroup C receptor 1a (FLVCR1a) knockout mouse model and showed that, by sustaining heme synthesis, FLVCR1a contributed to determine the energy phenotype in skeletal muscle cells and to modulate satellite cell differentiation and muscle regeneration.

Skeletal Muscle Regeneration after Extensive Cryoinjury of Caudal Myomeres in Adult Zebrafish

[npj Regenerative Medicine] A new cryoinjury model revealed that several myomeres efficiently regenerated within one month after wounding the zebrafish caudal peduncle.

HDAC Inhibitors as Pharmacological Treatment for Duchenne Muscular Dystrophy: A Discovery Journey from Bench to Patients

[Trends in Molecular Medicine] Scientists describe the molecular, preclinical, and clinical evidence supporting the efficacy of histone deacetylase (HDAC) inhibitors in countering disease progression by targeting pathogenic networks of gene expression in multiple muscle-resident cell types of patients with Duchenne muscular dystrophy.

A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation

[Nature Cardiovascular Research] Researchers employed a genome-wide CRISPR screen in a human induced pluripotent stem cell to cardiomyocyte (CM) differentiation system and revealed that BRD4 regulated CM differentiation.

Runx1+ Vascular Smooth Muscle Cells Are Essential for Hematopoietic Stem and Progenitor Cell Development In Vivo

[Nature Communications] Researchers identified a subpopulation of NG2+Runx1+ perivascular cells that display a sclerotome-derived vascular smooth muscle cell transcriptomic profile.

Parent Project Muscular Dystrophy Announces Pediatric Certified Duchenne Care Center, Penn State Health Children’s Hospital

[Parent Project Muscular Dystrophy] Parent Project Muscular Dystrophy announced the expansion of their Certified Duchenne Care Center Program with the certification of the clinic at Penn State Health Children’s Hospital in Hershey, Pennsylvania.

Age-Related Changes in Human Skeletal Muscle Transcriptome and Proteome Are More Affected by Chronic Inflammation and Physical Inactivity than Primary Aging

[Aging Cell] Investigators demonstrated for the first time the distinct role of primary aging and chronic inflammation/physical inactivity – the most important drivers of secondary aging, in the regulation of transcriptomic and proteomic profiles in human skeletal muscle.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.