Mast Cells (MCs) Induce Ductular Reaction Mimicking Liver Injury in Mice via MC-Derived TGF-β1 Signaling

Wild‐type, KitW‐sh, and Mdr2‐/‐ mice lacking l‐histidine decarboxylase were injected with vehicle or PKH26‐tagged murine mast cells pretreated with 0.01% DMSO or the TGF‐βR inhibitor,
[Hepatology]
Abstract

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Inhibition of Bruton’s Tyrosine Kinase Interferes with Pathogenic B-Cell Development in Inflammatory CNS Demyelinating Disease

Using mouse models of multiple scelrosis, investigators determined that evobrutinib, the first Burton’s tyrosine kinase inhibiting molecule being developed, dose-dependently inhibited antigen-triggered activation and maturation of B cells as well as their release of pro-inflammatory cytokines.
[Acta Neuropathologica]
Torke, S., Pretzsch, R., Häusler, D., Haselmayer, P., Grenningloh, R., Boschert, U., Brück, W., & Weber, M. S. (2020). Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease. Acta Neuropathologica. https://doi.org/10.1007/s00401-020-02204-z Cite
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Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart

The authors showed for the first time that the immune response is altered as a result of syngeneic neonatal cardiomyocyte transplantation after myocardial infarction leading to improved cardiac pump function as observed by magnetic resonance imaging in C57BL/6J mice.
[Cells]
Vasudevan, P., Wolfien, M., Lemcke, H., Lang, C. I., Skorska, A., Gaebel, R., Koczan, D., Lindner, T., Engelmann, R., Vollmar, B., Krause, B. J., Wolkenhauer, O., Lang, H., Steinhoff, G., & David, R. (2020). Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells, 9(8), 1825. https://doi.org/10.3390/cells9081825 Cite
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Exosomes — Beyond Stem Cells for Cardiac Protection and Repair

Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
[Stem Cells]
Balbi, C., & Vassalli, G. (n.d.). Exosomes — Beyond Stem Cells for Cardiac Protection and Repair. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3261 Cite
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HDAC Inhibitors Tune miRNAs in Extracellular Vesicles of Dystrophic Muscle-Resident Mesenchymal Cells

Investigators showed that extracellular vesicles released by mesenchymal cells mediated microRNAtransfer to muscle stem cells.
[EMBO Reports]
Sandonà, M., Consalvi, S., Tucciarone, L., De Bardi, M., Scimeca, M., Angelini, D. F., Buffa, V., D’Amico, A., Bertini, E. S., Cazzaniga, S., Bettica, P., Bouché, M., Bongiovanni, A., Puri, P. L., & Saccone, V. (2020). HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells. EMBO Reports, n/a(n/a), e50863. https://doi.org/10.15252/embr.202050863 Cite
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Enhancing Myocardial Repair with CardioClusters

Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
[Nature Communications]
Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-z Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
Abstract

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Immunological Distinctions between Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

the liver is a central player in immunoregulation. Altered immune responses are tightly associated with the development of non-alcoholic steatohepatitis and hepatocellular carcinoma.
[Experimental and Molecular Medicine]
Koo, S.-Y., Park, E.-J., & Lee, C.-W. (2020). Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-0480-3 Cite
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Intercellular Communication Controls Agonist-Induced Calcium Oscillations Independently of Gap Junctions in Smooth Muscle Cells

Investigators report the existence of a communication system among human smooth muscle cells that used mechanical forces to frequency modulate long-range calcium waves.
[Science Advances]
Stasiak, S. E., Jamieson, R. R., Bouffard, J., Cram, E. J., & Parameswaran, H. (2020). Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells. Science Advances, 6(32), eaba1149. https://doi.org/10.1126/sciadv.aba1149 Cite
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Corbus Pharmaceuticals Completes Enrollment in DETERMINE Phase III Study of Lenabasum for Treatment of Dermatomyositis

Corbus Pharmaceuticals Holdings, Inc. announced the completion of subject enrollment in DETERMINE, a Phase III study assessing the efficacy and safety of lenabasum for the treatment of dermatomyositis. The company expects to report topline results from this study in the fourth quarter of 2021.
[Corbus Pharmaceuticals Holdings, Inc.]
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Cellular, Mitochondrial and Molecular Alterations Associate with Early Left Ventricular Diastolic Dysfunction in a Porcine Model of Diabetic Metabolic Derangement

Investigators employed a translationally relevant large animal model with Diabetic Metabolic Derangement, having similar anatomic, physiologic and metabolic characteristics of the cardiovascular system with the human situation.
[Scientific Reports]
Heinonen, I., Sorop, O., van Dalen, B. M., Wüst, R. C. I., van de Wouw, J., de Beer, V. J., Octavia, Y., van Duin, R. W. B., Hoogstrate, Y., Blonden, L., Alkio, M., Anttila, K., Stubbs, A., van der Velden, J., Merkus, D., & Duncker, D. J. (2020). Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Scientific Reports, 10(1), 13173. https://doi.org/10.1038/s41598-020-68637-4 Cite
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Large-Scale Spontaneous Self-Organization and Maturation of Skeletal Muscle Tissues on Ultra-Compliant Gelatin Hydrogel Substrates

Scientists showed that C2C12 myoblasts spontaneously organized into highly aligned myotube tissues on the mm to cm scale, when cultured on sufficiently soft yet fully isotropic gelatin hydrogel substrates.
[Scientific Reports]
Jensen, J. H., Cakal, S. D., Li, J., Pless, C. J., Radeke, C., Jepsen, M. L., Jensen, T. E., Dufva, M., & Lind, J. U. (2020). Large-scale spontaneous self-organization and maturation of skeletal muscle tissues on ultra-compliant gelatin hydrogel substrates. Scientific Reports, 10(1), 13305. https://doi.org/10.1038/s41598-020-69936-6 Cite
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