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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Dysregulated FOXO1 Activity Drives Skeletal Muscle Intrinsic Dysfunction in Amyotrophic Lateral Sclerosis
[Acta Neuropathologica] Scientists described intrinsic abnormalities in amyotrophic lateral sclerosis (ALS) skeletal muscle, both in patient-derived muscle cells and in muscle cell lines with genetic knockdown of genes related to familial ALS, such as TARDBP and FUS.
Adipogenic-Myogenic Signaling in Engineered Human Muscle Grafts used to Treat Volumetric Muscle Loss
[Advanced Biology] Human myogenic progenitors (hMPs) were cultured on electrospun fibrin microfiber bundles and the therapeutic potential of engineered hMP tissue-engineered muscle grafts in the treatment of murine tibialis anterior volumetric muscle loss injuries was employed.
Clinical Trials In-a-Dish for Cardiovascular Medicine
[European Heart Journal] The authors discuss milestones in induced pluripotent stem cell differentiation and their applications from disease modeling to drug discovery in cardiovascular medicine.
Chronic Activation of Tubulin Tyrosination Improves Heart Function
[Circulation Research] Investigators tested the impact of chronic tubulin tyrosination in hypertrophic cardiomyopathy (HCM) mouse model, in human HCM cardiomyocytes, and SVBP-deficient human engineered heart tissues.
Leiomodin 2 Neonatal Dilated Cardiomyopathy Mutation Results in Altered Actin Gene Signatures and Cardiomyocyte Dysfunction
[NPJ Regenerative Medicine] Using patient-specific human induced pluripotent stem cell-derived cardiomyocytes and a mouse model harboring the homologous mutation to the patient, researchers discovered dysregulated actin-thin filament lengths, altered contractility and calcium handling properties, as well as alterations in the serum response factor-dependent signaling pathway.
Activation of the Muscle-to-Brain Axis Ameliorates Neurocognitive Deficits in an Alzheimer’s Disease Mouse Model via Enhancing Neurotrophic and Synaptic Signaling
[Geroscience] To investigate muscle-to-brain axis signaling in response to amyloid β (Aβ)-induced toxicity, we generated 5xFAD transgenic female mice with enhanced skeletal muscle function (5xFAD;cTFEB;HSACre) at prodromal (4-months old) and late (8-months old) symptomatic stages.
mTOR Signaling Controls the Formation of Smooth Muscle Cell-Derived Luminal Myofibroblasts during Vasculitis
[EMBO Reports] By performing lineage tracing studies in a murine model of Kawasaki disease, researchers revealed that luminal myofibroblasts developed independently of adventitial fibroblasts and endothelial cells, and instead derive from smooth muscle cells.
SOX9 Promotes Hypoxic Pulmonary Hypertension through Stabilization of DPP4 in Pulmonary Artery Smooth Muscle Cells
[Experimental Cell Research] Scientists investigated the role and molecular mechanism of SOX9 in hypoxic pulmonary hypertension in rats. The findings revealed that SOX9 was upregulated in hypoxia-exposed rats' pulmonary arteries and pulmonary artery smooth muscle cells.
Podocan Unraveled: Understanding Its Role in Tumor Proliferation and Smooth Muscle Regulation
[Biomedicine & Pharmacotherapy] The authors provide a comprehensive overview of Podocan's involvement in smooth muscle, cardiovascular system, and tumors by integrating current and past research.
Characterization of Infantile Cardiomyopathy in Alström Syndrome Using ALMS1 Knockout Induced Pluripotent Stem Cell Derived Cardiomyocyte Model
[Molecular Genetics and Metabolism] To understand the role of ALMS1 in infantile cardiomyopathy, the reduction of ALMS1 protein seen in Alström syndrome patients was modelled using human induced pluripotent stem cell-derived cardiomyocytes, in which ALMS1 was knocked out.
SRSF2 Is a Key Player in Orchestrating the Directional Migration and Differentiation of MyoD Progenitors during Skeletal Muscle Development
[eLife] Scientists offered insights into the role of SRSF2 in governing MyoD progenitors to specific muscle regions, thereby controling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.
Heart Failure Risk Assessment in Patients with Hypertrophic Cardiomyopathy Based on the H2FPEF Score
[European Journal of Heart Failure] Scientists investigated whether the H2FPEF score, which was developed to improve the diagnosis of heart failure (HF) with preserved ejection fraction, is associated with HF outcomes in patients with hypertrophic cardiomyopathy
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
