Scientists examined several proteomic- and RNA-Seq-based datasets of cardiac-enriched, cell-surface and membrane-associated proteins in human fetal and mouse neonatal ventricular cardiomyocytes.
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Lee, S.-H., Hadipour-Lakmehsari, S., Kim, D. H., Di Paola, M., Kuzmanov, U., Shah, S., Lee, J. J.-H., Kislinger, T., Sharma, P., Oudit, G. Y., & Gramolini, A. O. (2020). Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium. Scientific Data, 7(1), 425. https://doi.org/10.1038/s41597-020-00762-1 Cite
Scientists showed that protein levels of the Bromodomain and extra-terminal domain (BET) protein BRD4 were significantly increased in the muscle of the mouse model of Duchenne muscular dystrophy, the mdx mouse, and that pharmacological inhibition of the BET proteins had a beneficial outcome, tempering oxidative stress and muscle damage.
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Segatto, M., Szokoll, R., Fittipaldi, R., Bottino, C., Nevi, L., Mamchaoui, K., Filippakopoulos, P., & Caretti, G. (2020). BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy. Nature Communications, 11(1), 6108. https://doi.org/10.1038/s41467-020-19839-x Cite
The authors demonstrated that the Hippo pathway effectors YAP and TAZ play a critical role in maintaining the differentiated contractile phenotype of vascular smooth muscle cells.
Scientists discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.
[Journal of Cellular Physiology]
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Shang, Q., Shen, G., Chen, G., Zhang, Z., Yu, X., Zhao, W., Zhang, P., Chen, H., Tang, K., Yu, F., Tang, J., Liang, D., Jiang, X., & Ren, H. (n.d.). The emerging role of miR-128 in musculoskeletal diseases. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30179 Cite
The authors observed altered interactions between coactivator-associated arginine methyltransferase 1 (CARM1) and AMP-activated protein kinase (AMPK) and its network, including forkhead box protein O1, during muscle disuse.
Researchers identified nine distinct major clusters including myeloid‐derived cells, fibroblast/fibro/adipogenic progenitors, and skeletal muscle stem cells in glycerol‐injured skeletal muscle.
[Journal of Cachexia Sarcopenia and Muscle]
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Xu, Z., You, W., Chen, W., Zhou, Y., Nong, Q., Valencak, T. G., Wang, Y., & Shan, T. (n.d.). Single-cell RNA sequencing and lipidomics reveal cell and lipid dynamics of fat infiltration in skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcsm.12643 Cite
Investigators generated muscle stem cell‐specific androgen receptor and estrogen receptor 2 double knockout mice and pharmacologically inhibited the hypothalamic–pituitary–gonadal axis to mimic decreased serum levels of sex steroid hormones in aged mice.
[Journal of Cachexia Sarcopenia and Muscle]
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Kim, J.-H., Park, I., Shin, H. R., Rhee, J., Seo, J.-Y., Jo, Y.-W., Yoo, K., Hann, S.-H., Kang, J.-S., Park, J., Kim, Y. L., Moon, J.-Y., Choi, M. H., & Kong, Y.-Y. (n.d.). The hypothalamic–pituitary–gonadal axis controls muscle stem cell senescence through autophagosome clearance. Journal of Cachexia, Sarcopenia and Muscle, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcsm.12653 Cite
The authors investigated the role and the underlying regulatory mechanism of ubiquitin specific peptidase 7 (USP7) in myocardial infarction.
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Investigators found abundant transient receptor potential channel M2 (TRPM2) expression in lysosomes/autolysosomes in the primary cultured mouse aortic smooth muscle cells.
Osthole inhibited phosphodiesterase 4D activity to amplify autocrine prostaglandin E2 signaling in airway smooth muscle cells that eventually triggered cAMP/PKA-dependent relaxation of airways.
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Wang, S., Xie, Y., Huo, Y.-W., Li, Y., Abel, P. W., Jiang, H., Zou, X., Jiao, H.-Z., Kuang, X., Wolff, D. W., Huang, Y.-G., Casale, T. B., Panettieri, R. A., Wei, T., Cao, Z., & Tu, Y. (2020). Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma. Science Signaling, 13(659). https://doi.org/10.1126/scisignal.aax0273 Cite
The authors discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis.