Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Deletion of TECRL Promotes Skeletal Muscle Repair by Up-Regulating EGR2

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists deciphered a mechanism that enabled the proliferation and differentiation of satellite cells through the downregulation of trans-2,3-enoyl-CoA reductase like (TECRL) during muscle regeneration.

Allele-Specific Suppression of Variant MHC with High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy

[Circulation] On the basis of Cas13d homology structure, researchers rationally designed a series of Cas13d variants and obtained a high-precision Cas13d variant that specifically cleaved the MYH7 variant RNAs containing 1 allelic single nucleotide variant.

Vascular Smooth Muscle-Specific LRRC8A Knockout Ameliorates Angiotensin II-Induced Cerebrovascular Remodeling by Inhibiting the WNK1/FOXO3a/MMP Signaling Pathway

[Acta Pharmacologica Sinica] Researchers used vascular smooth muscle-specific leucine-rich repeat-containing family 8 A (LRRC8A) knockout mice and an angiotensin II-induced hypertension model.

Inhibition of TBL1 Cleavage Alleviates Doxorubicin-Induced Cardiomyocytes Death by Regulating the Wnt/β-Catenin Signal Pathway

[Cardiovascular Research] Researchers observed a reduction in transducin beta-like protein 1 (TBL1) protein expression levels as well as cleavage events in the transplanted cardiac tissues of patients diagnosed with dilated cardiomyopathy and doxorubicin-induced cardiotoxicity.

Skeletal Muscle Hypertrophy Rewires Glucose Metabolism: An Experimental Investigation and Systematic Review

[Journal Of Cachexia Sarcopenia And Muscle] The authors used mass spectrometry in hypertrophying C2C12 myotubes in vitro and plantaris mouse muscle in vivo and assessed metabolomic changes and the incorporation of the [U-13C6]glucose tracer.

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

[Circulation] Researchers used a proteomics screen to identify adducin, an actin capping protein previously not studied in cardiomyocytes, as a regulator of sarcomere disassembly.

Inhibition of Hmbox1 Promotes Cardiomyocyte Survival and Glucose Metabolism Through Gck Activation in Ischemia/Reperfusion Injury

[Circulation] Scientists studied the function of homeobox-containing 1 (Hmbox1) in exercise-induced physiological cardiac growth in mice after four weeks of swimming exercise. Hmbox1 expression was then evaluated in human heart samples from deceased patients with myocardial infarction and in the animal cardiac ischemia/reperfusion injury model.

Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology

[Arteriosclerosis Thrombosis And Vascular Biology] Challenges both specific, e.g. the lack of specific markers to thoroughly validate human induced pluripotent stem cell-smooth muscle cells (hiPSC-SMC), and general, e.g. a lack of transparency and consensus around methodology in the field, remain. Scientists highlight the recent successes and remaining challenges of the hiPSC-SMC model.

Heart Disease Research in Doberman Patient Replaces Animal Experiments

[Utrecht University] A team of researchers from Utrecht University and UMC Utrecht has received a grant of 936,587 euros from the ZonMw Open Competition for research into a serious heart condition that affects both humans and dogs, especially Dobermanns.

High Fat Diet Ameliorates Mitochondrial Cardiomyopathy in CHCHD10 Mutant Mice

[EMBO Molecular Medicine] Heterozygous S55L mice were subjected to chronic high-fat diet to decrease insulin sensitivity and glucose uptake and enhance fatty acid utilization in the heart.

Mitochondria Regulate Proliferation in Adult Cardiac Myocytes

[Journal Of Clinical Investigation] Researchers tested whether forced reversal of adult cardiomyocytes back to a fetal glycolytic phenotype would restore proliferative capacity. They deleted Uqcrfs1 in hearts of adult mice.

Sfrp5 Overexpression Reverses oxLDL-Induced Lipid Accumulation in HVSMCs

[Bioscience, Biotechnology, and Biochemistry] Researchers found that Sfrp5 expression in oxLDL-treated human vascular smooth muscle cells (HVSMCs) was downregulated. Sfrp5 overexpression inhibited the viability of HVSMCs induced by oxLDL.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.