Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Nilotinib Impairs Relaxation and Temporal Electro-Mechanical Integrity in Human iPS-Derived Cardiomyocyte Sheets
[Toxicology and Applied Pharmacology] Investigators adopted two-dimensional human induced pluripotent stem cell-derived cardiomyocyte sheets to examine the effects of nilotinib on their electrophysiological and mechanical properties besides intracellular calcium dynamics.
Limiting Cap-Dependent Translation Increases 20S Proteasomal Degradation and Protects the Proteomic Integrity in Autophagy-Deficient Skeletal Muscle
[Autophagy] Scientists revealed novel insights into the complex relationship in autophagy-deficient skeletal muscle. They demonstrated that despite a compensatory increase in proteasome level in response to autophagy impairment, 26S proteasome activity was not proportionally enhanced in autophagy-deficient skeletal muscle.
Increased Muscle Satellite Cell Content and Preserved Telomere Length in Response to Combined Exercise Training in Patients with FSHD
[Journal of Physiology] Researchers suggested that combined exercise training elicited beneficial muscular adaptations without impairing important indicators of skeletal muscle regenerative capacity in patients with facioscapulohumeral muscular dystrophy (FSHD).
CCN5 Suppresses Injury-Induced Vascular Restenosis by Inhibiting Smooth Muscle Cell Proliferation and Facilitating Endothelial Repair via Thymosin β4 and Cd9 Pathway
[European Heart Journal] CCN5 exerted a dual protective effect on in-stent restenosis (ISR) by inhibiting vascular smooth muscle cell proliferation and facilitating endothelial cell repair. CCN5rp-coated stent might be promising in the prevention of ISR after percutaneous coronary intervention.
Protease-Activated Receptors in Vascular Smooth Muscle Cells: A Bridge Between Thrombo-Inflammation and Vascular Remodelling
[Cell Communication and Signaling] The authors discuss recent advances on the role of protease-activated receptors signalling on vascular smooth muscle cells and specifically their role in vascular remodelling contributing to cardiovascular disease.
Tenaya Therapeutics Receives $8 Million Clinical Grant from California Institute for Regenerative Medicine
[Tenaya Therapeutics, Inc.] Tenaya Therapeutics, Inc. announced that the California Institute for Regenerative Medicine (CIRM), a state of California Agency that funds regenerative medicine, stem cell, and gene therapy research, has awarded Tenaya Therapeutics an $8.0 million CLIN2 grant.
Endothelial TRIM35-Regulated MMP10 Release Exacerbates Calcification of Vascular Grafts
[Advanced Science] To test how endothelial cells interact with smooth muscle cells (SMC) in artery grafts, single-cell analysis of wild-type mice is first performed using an arterial isograft mouse model and found robust cytokine-mediated signaling pathway activation and SMC proliferation, together with upregulated endothelial tripartite motif 35 (TRIM35) expression.
N-Cadherin Promotes Cardiac Regeneration by Potentiating Pro-Mitotic β-Catenin Signaling in Cardiomyocytes
[Nature Communications] Comparative transcriptome analyses identified adherens junction protein N-Cadherin as a crucial regulator of cardiomyocyte proliferation/renewal.
Dynamic Map Illuminates Hippo-cMyc Module Crosstalk Driving Cardiomyocyte Proliferation
[Development] Investigators developed a computational model of the cardiomyocyte proliferation regulatory network to obtain key regulators and systems-level understanding.
Human Epicardial Organoids from Pluripotent Stem Cells Resemble Fetal Stage with Potential Cardiomyocyte- Transdifferentiation
[Cell & Bioscience] After 8-days treatment of TGF-beta following by bFGF, cells entered into epithelium-mesenchymal transition and gave rise to smooth muscle cells. Epicardium could also integrate and invade into mouse heart with SNAI1 expression, and give birth to numerous cardiomyocyte-like cells.
Impaired Hydrogen Sulfide Biosynthesis Underlies Eccentric Contraction-Induced Force Loss in Dystrophin-Deficient Skeletal Muscle
[Journal of Clinical Investigation] Investigators showed that the cysteine proteome of skeletal muscle functioned as a redox buffer in wild-type and murine dystrophin-deficient (mdx)muscle during eccentric contractions, but the buffer capacity in mdx muscle was significantly compromised by elevated basal protein oxidation.
The Role of MEGF10 in Myoblast Fusion and Hypertrophic Response to Overload of Skeletal Muscle
[Journal of Muscle Research and Cell Motility] To better understand the role of MEGF10 in satellite cells, investigators overexpressed human multiple EGF domain protein 10 (MEGF10) in mouse H-2kb-tsA58 myoblasts and found that it inhibited fusion.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.