Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Regulatory T Cells Require IL6 Receptor Alpha Signaling to Control Skeletal Muscle Function and Regeneration

[Cell Metabolism] Using exercise and sarcopenia models, mice lacking IL6Rα on T cells demonstrated deficits in regulatory T cells, their functional maturation, and a more pronounced decline in muscle mass.

Oncometabolite D-2-Hydroxyglutarate—Dependent Metabolic Reprogramming Induces Skeletal Muscle Atrophy during Cancer Cachexia

[Communications Biology] Based on the up-regulation of catabolism and down-regulation of anabolism, researchers showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigating their direct effect on muscle atrophy.

Myeloid-Derived Growth Factor Suppresses VSMC Dedifferentiation and Attenuates Postinjury Neointimal Formation in Rats by Activating S1PR2 and Its Downstream Signaling

[Acta Pharmacologica Sinica] Researchers investigated the effect of myeloid-derived growth factor to postinjury neointimal formation and the underlying mechanisms. Rat carotid arteries balloon-injured model was established.

Piezo Channels in Stretch Effects on Developing Human Airway Smooth Muscle

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Using 18-22-week gestation human fetal airway smooth muscle as an in vitro model, the authors tested the hypothesis that mechanosensitive Piezo channels contributed to stretch effects.

LKB1 Delays Atherosclerosis by Inhibiting Phenotypic Transformation of Vascular Smooth Muscle Cells

[International Journal Of Cardiology] ApoE−/− mice with vascular smooth muscle cells-specific overexpression of liver kinase B1 (LKB1) were constructed by adeno-associated virus transfection technique, and then fed with high-fat diet for eight weeks.

Muscle: An Independent Contributor to the Neuromuscular Spinal Muscular Atrophy Disease Phenotype

[JCI Insight] The authors discuss how survival motor neuron (SMN) might regulate the health of myofibers and their progenitors. They also speculate on therapeutic outcomes of failing to raise muscle SMN to healthful levels and present strategies to restore function to this tissue to ensure better treatment results.

Monash-Led National Program to Improve Treatments for Kids with Muscle Disease

[Monash University] A national clinical consortium has joined forces to improve care outcomes for children born with congenital muscle disease, led by Monash University’s Professor Peter Currie.

miRNA-126a Plays Important Role in Myoblast and Endothelial Cell Interaction

[Scientific Reports] Scientists identified miRNA that were up-regulated in satellite cell-derived myoblasts treated with stromal derived factor-1 (SDF-1) and/or down-regulated in cells in which the expression of CXCR4 or CXCR7, that is, SDF-1 receptors, was silenced.

KLF4 Regulates Skeletal Muscle Development and Regeneration by Directly Targeting P57 and Myomixer

[Cell Death & Disease] Investigators revealed that Krüppel-like factor 4 (KLF4) played a critical role in skeletal muscle development and regeneration. Specific knockout of KLF4 in skeletal muscle impaired muscle formation further affecting physical activity and also defected skeletal muscle regeneration.

Accumulation of Endogenous Adenosine Improves Cardiomyocyte Metabolism via Epigenetic Reprogramming in an Ischemia-Reperfusion Model

[Redox Biology] Scientists investigated the role of cellular adenosine in epigenetic regulation on cardiomyocyte gene expression, glucose metabolism and tolerance to ischemia/reperfusion (I/R). Evans blue/TTC staining and echocardiography were used to assess the extent of I/R injury in mice.

S100a9 Inhibits Atg9a Transcription and Participates in Suppression of Autophagy in Cardiomyocytes Induced by β1-Adrenoceptor Autoantibodies

[Cellular & Molecular Biology Letters] The active immunity method was used to establish a β1-AA-induced mouse cardiac dysfunction model, and RT-PCR and western blot were used to detect changes in gene and protein expression in cardiomyocytes.

miR-200a-3p Overexpression Alleviates Diabetic Cardiomyopathy Injury in Mice by Regulating Autophagy through the FOXO3/Mst1/Sirt3/AMPK Axis

[Peerj Life & Environment] Researchers used db/db mice to simulate the animal model of diabetic cardiomyopathy and the expression of miR-200a-3p was then examined by RT-qPCR. Tail vein injection of mice was done with rAAV-miR-200a-3p for eight weeks, and cardiac function was assessed by cardiac ultrasound.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.