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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
RNA-Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post-Transcriptional Manner
By performing integrated bioinformatic analysis of snRNA-seq data from neonatal and adult hearts, this study identified Hnrnpa1 as a potential RNA-binding protein regulating cardiomyoctye...
Graphene SU-8 Platform for Enhanced Cardiomyocyte Maturation and Intercellular Communication in Cardiac Drug Screening
[ACS Nano] Investigators proposed the application of monolayer graphene, transferred onto SU-8 cantilevers integrated with a microelectrode array, to evaluate its influence on the structural, functional, and electro-mechano-physiological properties of cardiomyocytes.
GSK3 Inhibition Improves Skeletal Muscle Function and Whole-Body Metabolism in Male Mouse Models of Duchenne Muscular Dystrophy
[Nature Communications] Researchers showed the effects of glycogen synthase kinase 3 (GSK3) inhibition in male DBA/2J and C57BL/10 mdx mice. GSK3 inhibition in C57 mdx mice also improved muscle fatigue resistance and increased cage ambulation.
PIEZO1 Attenuates Marfan Syndrome Aneurysm Development Through TGF-β Signaling Pathway Inhibition via TGFBR2
[European Heart Journal] The role of Piezo-type mechanosensitive ion channel component 1 (Piezo1) in Marfan syndrome (MFS) was investigated and the activation of PIEZO1 was identified as a potential treatment for MFS.
Mechanical Activation of cPLA2 Impedes Fatty Acid β-Oxidation in Vein Grafts
[Advanced Science] Researchers highlighted the critical role of cytosolic Phospholipase A2 (cPLA2)/ Yin Yang 1 (YY1)/ carnitine palmitoyltransferase 1b signaling in coordinating vascular smooth muscle cell mechanical activation by inhibiting fatty acid β-oxidation.
Macrophage-Specific κ-OR Knockout Exacerbates Inflammation in Hypoxic Pulmonary Hypertension
[European Journal of Pharmacology] Scientists revealed that hypoxia promoted macrophage infiltration and pulmonary artery smooth muscle cell proliferation.
Muscle Regeneration and Muscle Stem Cells in Metabolic Disease
[Free Radical Biology and Medicine] The authors review the impact of diabetes and metabolic disease on MuSCs and skeletal muscle, including potential mechanisms for impaired muscle regeneration and muscle stem cell dysfunction, and how these deficits could be addressed.
Cytokinetics Announces FDA Acceptance of New Drug Application for Aficamten for the Treatment of Obstructive Hypertrophic Cardiomyopathy
[Cytokinetics, Inc.] Cytokinetics, Inc.announced that the US FDA has accepted the company’s New Drug Application for aficamten, a next-in-class cardiac myosin inhibitor, for the treatment of obstructive hypertrophic cardiomyopathy.
Impairing Ferroptosis through the PI3K/Akt/Nrf2 Pathway: The Way for Nerve Growth Factor to Mitigate Hypoxia-induced Cardiomyocyte Damage
[Cell Biochemistry and Biophysics] In H9C2 cells, exposure to hypoxia for 24 hours led to weakened nerve growth factor level, as well as lowered cell vitality and superoxide dismutase activity, but elevated levels of LDH, Fe2+, malondialdehyde, and reactive oxygen species, triggering ferroptosis.
Dilated Cardiomyopathy–Associated Skeletal Muscle Actin (ACTA1) Mutation R256H Disrupts Actin Structure and Function and Causes Cardiomyocyte Hypocontractility
[Proceedings of The National Academy of Sciences of The United States of America] The authors demonstrated that a skeletal muscle actin mutation potently caused multiple defects in actin function at the atomic and molecular scales, and it functions in a dominant fashion, leading to cardiomyocyte contractile defects.
Empagliflozin Attenuates Neointima Formation After Arterial Injury and Inhibits Smooth Muscle Cell Proliferation and Migration by Suppressing Platelet‐Derived Growth Factor–Related Signaling
[Journal of The American Heart Association] Researchers highlighted the crucial role of suppressing platelet‐derived growth factor‐related signaling in mediating the beneficial effects of empagliflozin on neointima formation and vascular smooth muscle cell function, which were independent of sodium-glucose cotransporter 2 and glycemic control.
Extracellular Matrix-Mimicking Cryogels Composed of Methacrylated Fucoidan Enhance Vascularized Skeletal Muscle Regeneration Following Volumetric Muscle Loss
[International Journal of Biological Macromolecules] Methacrylated fucoidan (FuMA) was synthesized by grafting the methacryloyl group onto fucoidan. In vitro experiments demonstrated that treatment with FuMA significantly up-regulated myogenic markers' expression and promoted myotubes' formation in C2C12 myoblast cells.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
