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Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
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Spatiotemporal Precision Interventions for Cardiac Repair and Regenerative Therapy
[Experimental & Molecular Medicine] Aligning therapeutic action with the intrinsic biology of myocardial healing provides a rational pathway toward more effective, durable, and biologically informed strategies for cardiac repair and, where biology permits, regeneration.
EHMT2 Aggravates Vascular Remodeling via Epigenetic Inhibition of GADD45G
[Experimental & Molecular Medicine] Scientists investigated the contribution of EHMT2 to vascular smooth muscle cell (VSMC) proliferation, migration and neointima formation following vascular injury using carotid artery injury models and in vitro VSMC studies.
Nuclear Envelope Budding Enables Export of Large Transcripts in Muscle Cells
[Cell] Researchers used a combination of electron and fluorescence microscopy to demonstrate that nuclear envelope budding events occur following myoblast differentiation into myotubes and concomitant with the expression of extremely long muscle-specific transcripts.
Microtubule Dynamics Control the Direction of Cardiomyocyte Growth
[Science] Investigators found that microtubule dynamics could act as a toggle to direct cardiomyocyte growth. Increasing microtubule stability drove cellular widening, concomitant with redirecting mRNA export and translation along the width of the cell and reinforcement of the intercalated disc.
Restoration of Structural Organization in Engineered Cardiac Microtissues Is Promoted by Cardiomyocyte Beating
[Communications Biology] Scientists engineered cardiac microtissues by embedding cardiac cells in constrained collagen hydrogels, modeling aligned (anisotropic) and disorganized (isotropic) tissues. By varying tissue constraint geometry, they created conditions that either promoted or restricted anisotropy and assessed the contribution of cardiomyocyte contraction.
New York Blood Center Enterprises and Biohub Launch Collaboration to Advance Cord Blood–Derived Stem Cell Platforms
[New York Blood Center Enterprises] The New York Blood Center Enterprises announced that they are collaborating to turn discarded cells into a library of cord blood-derived iPSCs, designed to be broadly compatible with human immune systems and available as shared research resources for regenerative medicine and cell therapy.
iPSC-Derived Skeletal Muscle Spheroids for Duchenne Muscular Dystrophy Modeling
[Skeletal Muscle] Investigators validated a 3D culture of skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling, as compared to the traditional 2D culture, while investigating the pathophysiological mechanisms of dystrophin deficiency in vitro.
Engineered Cardiac Patches from hiPSC-Derived Cardiomyocytes
[Stem Cell Research & Therapy] Engineered hiPSC-cardiomyocyte (CM) cardiac patches, 3D constructs of hiPSC-CMs combined with supporting cells and scaffolds, represent a rapidly advancing frontier in regenerative cardiology. The authors highlight recent advances in maturation protocols, vascularization strategies, and scaffold engineering of hiPSC-CM patches.
Mechanobiological Landscape of Muscle Stem Cells
[Skeletal Muscle] Scientists summarize the mechanosensory mechanisms through which muscle stem cells (MuSCs) respond to mechanical perturbations in regenerating myofibers. They highlight recent advances in mechanosensitive receptors, including ion channels, and the downstream mechano-signaling pathways that shape MuSC fate.
Precision BioSciences Activates First Clinical Trial Site and Begins Patient Enrollment in Phase 1/2 FUNCTION-DMD Study
[Precision BioSciences, Inc. ] Precision BioSciences, Inc. announced the activation of the first clinical trial site and the opening of patient screening and enrollment for PBGENE-Duchenne muscular dystrophy (DMD). PBGENE-DMD, an in vivo gene editing treatment for DMD, is being evaluated in the Phase I/II FUNCTION-DMD study.
A Skeletal Muscle Atlas Shows Neuromuscular Junction Adaptations to Growth and Atrophy
[Developmental Cell] Researchers presented a single-nucleus and single-cell transcriptomic atlas, coupled with spatial profiling, of mouse limb skeletal muscle under resting conditions and during experimentally induced atrophy or hypertrophy.
Entos Pharmaceuticals and the L-CMD Research Foundation Collaborate to Develop Curative Therapy for LMNA-Related Congenital Muscular Dystrophy
[Entos Pharmaceuticals, Inc. ] Entos Pharmaceuticals, Inc. announced a collaboration with the L-CMD Research Foundation, a nonprofit that urgently translates scientific research into treatments for LMNA-related congenital muscular dystrophy (L-CMD).
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
