Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Arginine Ingestion Inhibits Phagocyte Invasion in Eccentrically Contracted Rat Fast-Twitch Muscle

[Journal of Muscle Research and Cell Motility] Scientists investigated whether prior ingestion of L-arginine, a nitric oxide precursor, inhibited eccentric contraction-induced macrophage invasion.

KLF13 Promotes VSMCs Phenotypic Dedifferentiation by Directly Binding to the SM22α Promoter

[Journal of Cellular Physiology] The authors investigated the relationship between KLF13 and SM22α expression in normal and atherosclerotic plaques by bioanalysis, and observed a significant increase in KLF13 levels in the atherosclerotic plaques of both human patients and ApoE−/− mice.

Proximal Telomeric Decompaction Due to Telomere Shortening Drives FOXC1-Dependent Myocardial Senescence

[Nucleic Acids Research] Investigators demonstrated that in heart failure patient cardiomyocytes, telomeres were shortened compared to healthy controls.

HOIL-1L Deficiency Induces Cell Cycle Alteration Which Causes Immaturity of Skeletal Muscle and Cardiomyocytes

[Scientific Reports] The authors elucidated the mechanisms by which myopathy and dilated cardiomyopathy develop using the murine myoblast cell line C2C12 and disease-specific human induced pluripotent stem cells.

Human Skeletal Muscle Aging Atlas

[Human Skeletal Muscle Aging Atlas] Researchers profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment.

Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation

[Circulation] The authors leveraged 2 models of in vitro cultured adult mouse cardiomyocytes and in vivo adeno-associated virus serotype 9 cardiomyocyte–targeted delivery of reprogramming factors in adult mice to study cardiomyocyte dedifferentiation.

A Versatile High-Throughput Assay Based on 3D Ring-Shaped Cardiac Tissues Generated from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

[eLife] Researchers developed a 96-well plate assay which allowed fast, reproducible, and high-throughput generation of three dimensional cardiac rings around a deformable optically transparent hydrogel pillar of known stiffness.

Thiamine-Modified Metabolic Reprogramming of Human Pluripotent Stem Cell-Derived Cardiomyocyte under Space Microgravity

[Signal Transduction and Targeted Therapy] Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium cycling. Metabolomic and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight, especially thiamine metabolism.

Hypoxia Treatment and Resistance Training Alters microRNA Profiling in Rats Skeletal Muscle

[Scientific Reports] Scientists employed miRNA microarray analysis to investigate the expression profile of miRNAs in skeletal muscle from an animal model of hypoxia-induced muscle atrophy and resistance training aimed at mitigating muscle atrophy.

RSAD2 Is Abundant in Atherosclerotic Plaques and Promotes Interferon-Induced CXCR3-Chemokines in Human Smooth Muscle Cells

[Scientific Reports] The authors harnessed publicly available human carotid atherosclerotic data to explore radical S-adenosyl-L-methionine domain containing 2 (RSAD2) in lesions and employed siRNA-mediated gene-knockdown to investigate its function in interferon gamma-stimulated human aortic smooth muscle cells.

Arterial Smooth Muscle Cell AKAP150 Mediates Exercise-Induced Repression of CaV1.2 Channel Function in Cerebral Arteries of Hypertensive Rats

[Arteriosclerosis Thrombosis And Vascular Biology] Spontaneously hypertensive rats and newly generated smooth muscle–specific AKAP150 knockin mice were used to assess the role of myocyte AKAP150/CaV1.2 channel in regulating cerebral artery function after exercise intervention.

MicroRNA-Mediated Regulation of Muscular Atrophy: Exploring Molecular Pathways and Therapeutics

[Molecular Medicine Reports] The authors lay a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explore other regulatory pathways, such as autophagy and inflammatory signaling.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.