Large-Scale Spontaneous Self-Organization and Maturation of Skeletal Muscle Tissues on Ultra-Compliant Gelatin Hydrogel Substrates

Scientists showed that C2C12 myoblasts spontaneously organized into highly aligned myotube tissues on the mm to cm scale, when cultured on sufficiently soft yet fully isotropic gelatin hydrogel substrates.
[Scientific Reports]
Jensen, J. H., Cakal, S. D., Li, J., Pless, C. J., Radeke, C., Jepsen, M. L., Jensen, T. E., Dufva, M., & Lind, J. U. (2020). Large-scale spontaneous self-organization and maturation of skeletal muscle tissues on ultra-compliant gelatin hydrogel substrates. Scientific Reports, 10(1), 13305. https://doi.org/10.1038/s41598-020-69936-6 Cite
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Intercellular Communication Controls Agonist-Induced Calcium Oscillations Independently of Gap Junctions in Smooth Muscle Cells

Investigators report the existence of a communication system among human smooth muscle cells that used mechanical forces to frequency modulate long-range calcium waves.
[Science Advances]
Stasiak, S. E., Jamieson, R. R., Bouffard, J., Cram, E. J., & Parameswaran, H. (2020). Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells. Science Advances, 6(32), eaba1149. https://doi.org/10.1126/sciadv.aba1149 Cite
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Corbus Pharmaceuticals Completes Enrollment in DETERMINE Phase III Study of Lenabasum for Treatment of Dermatomyositis

Corbus Pharmaceuticals Holdings, Inc. announced the completion of subject enrollment in DETERMINE, a Phase III study assessing the efficacy and safety of lenabasum for the treatment of dermatomyositis. The company expects to report topline results from this study in the fourth quarter of 2021.
[Corbus Pharmaceuticals Holdings, Inc.]
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Cellular, Mitochondrial and Molecular Alterations Associate with Early Left Ventricular Diastolic Dysfunction in a Porcine Model of Diabetic Metabolic Derangement

Investigators employed a translationally relevant large animal model with Diabetic Metabolic Derangement, having similar anatomic, physiologic and metabolic characteristics of the cardiovascular system with the human situation.
[Scientific Reports]
Heinonen, I., Sorop, O., van Dalen, B. M., Wüst, R. C. I., van de Wouw, J., de Beer, V. J., Octavia, Y., van Duin, R. W. B., Hoogstrate, Y., Blonden, L., Alkio, M., Anttila, K., Stubbs, A., van der Velden, J., Merkus, D., & Duncker, D. J. (2020). Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Scientific Reports, 10(1), 13173. https://doi.org/10.1038/s41598-020-68637-4 Cite
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Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes

Researchers investigated the metabolic landscape of Danon disease by applying a multi-omics approach and combined structural and functional readouts provided by Raman and atomic force microscopy.
[Journal of Clinical Medicine]
Del Favero, G., Bonifacio, A., Rowland, T. J., Gao, S., Song, K., Sergo, V., Adler, E. D., Mestroni, L., Sbaizero, O., & Taylor, M. R. G. (2020). Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes. Journal of Clinical Medicine, 9(8), 2457. https://doi.org/10.3390/jcm9082457 Cite
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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Human Pluripotent Stem Cell-Derived Cardiomyocytes as a Target Platform for Paracrine Protection by Cardiac Mesenchymal Stromal Cells

Investigators tested the impact of paracrine signals on human cardiomyocytes, using human pluripotent stem cell-derived cardiomyocytes as the target of mouse and human cardiac mesenchymal stromal cells with progenitor-like features.
[Scientific Reports]
Constantinou, C., Miranda, A. M. A., Chaves, P., Bellahcene, M., Massaia, A., Cheng, K., Samari, S., Rothery, S. M., Chandler, A. M., Schwarz, R. P., Harding, S. E., Punjabi, P., Schneider, M. D., & Noseda, M. (2020). Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells. Scientific Reports, 10(1), 13016. https://doi.org/10.1038/s41598-020-69495-w Cite
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Skeletal Muscle Energy Metabolism during Exercise

The authors provide an overview of exercise metabolism and the key regulatory mechanisms ensuring that ATP resynthesis is closely matched to the ATP demand of exercise.
[Nature Metabolism]
Hargreaves, M., & Spriet, L. L. (2020). Skeletal muscle energy metabolism during exercise. Nature Metabolism, 1–12. https://doi.org/10.1038/s42255-020-0251-4 Cite
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Satellite Cell Self-Renewal in Endurance Exercise Is Mediated by Inhibition of Mitochondrial Oxygen Consumption

Young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
[Journal of Cachexia Sarcopenia and Muscle]
Abreu, P., & Kowaltowski, A. J. (n.d.). Satellite cell self-renewal in endurance exercise is mediated by inhibition of mitochondrial oxygen consumption. Journal of Cachexia, Sarcopenia and Muscle, n/a(n/a). https://doi.org/10.1002/jcsm.12601 Cite
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Human Pluripotent Stem Cell-Derived Cardiomyocytes as a Target Platform for Paracrine Protection by Cardiac Mesenchymal Stromal Cells

Investigators tested the impact of paracrine signals on human cardiomyocytes, using human pluripotent stem cell-derived cardiomyocytes as the target of mouse and human cardiac mesenchymal stromal cells with progenitor-like features.
[Scientific Reports]
Constantinou, C., Miranda, A. M. A., Chaves, P., Bellahcene, M., Massaia, A., Cheng, K., Samari, S., Rothery, S. M., Chandler, A. M., Schwarz, R. P., Harding, S. E., Punjabi, P., Schneider, M. D., & Noseda, M. (2020). Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells. Scientific Reports, 10(1), 13016. https://doi.org/10.1038/s41598-020-69495-w Cite
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More than Just a Garbage Can: Emerging Roles of the Lysosome as an Anabolic Organelle in Skeletal Muscle

The authors describe the molecular regulation of lysosome biogenesis and detail the emerging anabolic roles of the lysosome in skeletal muscle with particular emphasis on how these roles may mediate adaptations to chronic resistance exercise.
[American Journal of Physiology-Cell Physiology]
Abou Sawan, S., Mazzulla, M., Moore, D. R., & Hodson, N. (2020). More than just a garbage can: emerging roles of the lysosome as an anabolic organelle in skeletal muscle. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00241.2020 Cite
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Heart Regeneration Using Pluripotent Stem Cells

In this review, the authors summarize the updated knowledge, perspectives, and limitations of PSC-derived cardiomyocytes for heart regeneration.
[Journal of Cardiology]
Kadota, S., Tanaka, Y., & Shiba, Y. (2020). Heart regeneration using pluripotent stem cells. Journal of Cardiology, 0(0). https://doi.org/10.1016/j.jjcc.2020.03.013 Cite
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