Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

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SLC4A3-Related Short QT Syndrome Assessed in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Mechanisms of Ventricular Arrhythmia and Sudden Cardiac Death

March 9, 2026

[European Heart Journal] Human induced pluripotent stem cell-derived cardiomyocytes from each index short QT syndrome patient were developed, as well as an isogenic cell line with variant correction and HEK 293T cells transfected with SLC4A3 expression constructs expressing either wild type SLC4A3 or the variants.

Highly Integrated Chip for Continuous Chemical Synthesis, Purification, and Inline Biosensoric Monitoring of Biological Activity on Stem Cell-Derived 3D Cardiomyocyte Cultures

March 9, 2026

[Biosensors & Bioelectronics] The synthesis of the cardioactive drug propranolol from its precursor was chosen and successfully established in a continuous microfluidic setup. For sensitive detection of bioactivity, human stem cell-derived cardiomyocyte 3D cultures were used.

PFKM Governs Metabolic Shifts Throughout Skeletal Muscle Differentiation

March 9, 2026

[Nature Metabolism] Researchers revealed spatiotemporal dynamics of phosphofructokinase 1, a key glycolytic enzyme, within the skeletal muscle lineage.

Bioengineered Human Pre-Vascularized Microtissues Reconstruct Vascular Niche and Regenerative Microenvironment to Enhance Functional Skeletal Muscle Regeneration

March 9, 2026

[Biomaterials] Scientists highlighted that human pre-vascularized microtissue can effectively re-establish the vascular regenerative microenvironment, which presented an innovative therapeutic approach to promote functional skeletal muscle regeneration following volumetric muscle loss.

Age-Related Adiponectin Resistance in Human Skeletal Muscle Dysfunction: In Vivo and In Vitro Evidence

March 9, 2026

[Journal of Translational Medicine] Excessive AMPK activity, in the context of impaired AdipoR2 function, contributes to redox imbalance and metabolic dysfunction in the skeletal muscle, favoring a “senescent-like” phenotype.

Semaglutide Reduces Murine Blood Pressure through the Vascular Smooth Muscle GLP-1 Receptor

March 9, 2026

[JCI Insight] Investigators showed that GLP-1 receptors (GLP-1Rs) in vascular smooth muscle cells are essential for semaglutide-mediated blood pressure (BP) reduction in mice. In contrast, GLP-1Rs in Tie2+ endothelial or immune cells are not required for semaglutide to lower BP.

Preventive and Inhibitory Effects of Salacia on Sustained Contraction of Vascular Smooth Muscle Cells and Characterization of the Active Compounds

March 9, 2026

[Biochemistry and Biophysics Reports] Researchers suggests that water-soluble compounds from Salacia may prevent or attenuate sphingosylphosphorylcholine-induced vasospasm and its associated severe vascular diseases.

The cGAS-STING signaling pathway: A central regulator and novel therapeutic target in skeletal muscle pathophysiology

March 9, 2026

[Biochemical Pharmacology] The authors elaborate on the central position and “double-edged sword” role of the cGAS–STING pathway in skeletal muscle pathophysiology.

Dyne Therapeutics Announces Initiation of Phase III HARMONIA Trial of Z-Basivarsen in Myotonic Dystrophy Type 1 (DM1)

March 9, 2026

[Dyne Therapeutics, Inc.] Dyne Therapeutics, Inc. announced the initiation of the Phase III HARMONIA trial of zeleciment basivarsen, in individuals with DM1.

Microfluidic Modeling of Macrophage-Induced Cardiac Inflammation Using NF-κB Reporter Cardiomyocytes

February 23, 2026

[Advanced Healthcare Materials] Researchers developed an in vitro cardiac inflammation model that enables controlled investigation of macrophage-cardiomyocyte interactions.

Empagliflozin Protects against Doxorubicin-Induced Arrhythmia by AMPK/mTOR-Mediated Autophagy in Cardiomyocyte

February 23, 2026

[European Journal of Pharmacology] Investigators demonstrated that empagliflozin reduced the incidence of ventricular arrhythmia by regulating AMPK/mTOR signaling and restored autophagic flux in DOX-treated rats and neonatal rat ventricular cardiomyocytes.

Distinct HIF1α and HIF2α Functions Control Skeletal Muscle Metabolism and Erythropoiesis

February 23, 2026

[Journal of Clinical Investigation] Scientists developed mice with myofiber-specific knockouts of prolyl hydroxylase proteins, in which HIFα is stabilized, and inducible myofiber-specific overexpression of stable HIF1α or HIF2α to explore the role of HIFα in myofibers.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.