Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Advances in In Vitro Models of Neuromuscular Junction: Focusing on Organ-on-a-Chip, Organoids, and Biohybrid Robotics

[Advanced Materials] The authors review recent developments in in vitro neuromuscular junction (NMJ) models with 2D or 3D cultures, from organ-on-a-chip and organoids, to biohybrid robotics. They also introduce related derivative techniques for functional analysis of the NMJ.

Knockdown of Deleterious miRNA in Progenitor Cell–Derived Small Extracellular Vesicles Enhances Tissue Repair in Myocardial Infarction

[Science Advances] MiR-192-5p– and miR-432-5p–depleted cardiac c-kit+ cell-V small extracellular vesicles enhanced cardiac function by reducing fibrosis and necrotic inflammatory responses.

Engineered Cardiac Tissue Model of Restrictive Cardiomyopathy for Drug Discovery

[Cell Reports Medicine] Human variants in filamin C are linked to a variety of cardiomyopathies, and in this study, scientists investigated an in-frame deletion in a patient with restrictive cardiomyopathy.

CAR Links Hypoxia Signaling to Improved Survival after Myocardial Infarction

[Experimental And Molecular Medicine] To elucidate whether the coxsackievirus and adenovirus receptor (CAR) contributed to hypoxia signaling and myocardial infarction pathology, researchers used a gain- and loss-of-function approach in transfected HEK293 cells, H9c2 cardiomyocytes and CAR knockout mice.

Myoscaffolds Reveal Laminin Scarring Is Detrimental for Stem Cell Function While Sarcospan Induces Compensatory Fibrosis

[NPJ Regenerative Medicine] Researchers investigated whether fibrotic extracellular matrixscarring affected human skeletal muscle progenitor cell functions that are essential for myoregeneration.

Dynamic Transcriptomic Responses to Acute Exercise Stimuli in Young Adults

[Physiological Genomics] Scientists assessed transcriptome-wide responses in skeletal muscle and circulating extracellular vehicles to a single exercise bout in young adults randomized to conventional resistance training or high-intensity training.

Distinct Myofibre Domains of the Human Myotendinous Junction Revealed by Single Nucleus RNA-Seq

[Journal Of Cell Science] Investigators profiled 24,161 nuclei in semitendinosus muscle-tendon samples from three healthy males by single nucleus RNA-sequencing, alongside spatial transcriptomics, to gain insight into the genes characterizing this specialization in humans.

Silencing EIF3A Ameliorates Pulmonary Arterial Hypertension through HDAC1 and PTEN/PI3K/AKT Pathway In Vitro and In Vivo

[Cellular Signalling] Pulmonary arterial smooth muscle cells (PASMC) were isolated from rats and treated with PDGF-BB to simulate PASMC proliferation, and shRNA for EIF3 was conducted to investigate the mechanism behind the role of EIF3A in PASMC function in vitro.

JMJD1C Promotes Smooth Muscle Cell Proliferation by Activating Glycolysis in Pulmonary Arterial Hypertension

[Cell Death Discovery] In vitro, hypoxia-induced hyperproliferation and activated glycolytic processes in mouse pulmonary arterial smooth muscle cells were impaired by JMJD1C knockdown.

Obesity and the Risk of Cardiometabolic Diseases

[Nature Reviews Cardiology] The authors present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardiometabolic consequences, and discuss the major mechanisms involved in the association between obesity and the risk of cardiometabolic diseases.

Metabolic Landscape in Cardiac Aging: Insights into Molecular Biology and Therapeutic Implications

[Signal Transduction And Targeted Therapy] Scientists summarize emerging concepts about metabolic landscapes of cardiac aging, with specific focuses on why metabolic profile alters during cardiac degeneration and how we could utilize the current knowledge to improve the management of cardiac aging.

FDA Shocks Sarepta, Ordering AdComm for DMD Gene Therapy in Sudden Change of Heart

[Fierce Biotech] Two weeks after saying the FDA would assess its gene therapy without an advisory committee meeting, Sarepta has revealed the agency will now convene experts to dig into the data on its Duchenne muscular dystrophy submission.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.