A Machine Learning Pipeline Revealing Heterogeneous Responses to Drug Perturbations on Vascular Smooth Muscle Cell Spheroid Morphology and Formation

To identify the heterogeneous responses of drug treatments, scientists created an in vitro experimental model system using vascular smooth muscle cells spheroids and developed a machine learning-based computational method called HETEROID.
[Scientific Reports]
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LncRNA HSPA7 in Human Atherosclerotic Plaques Sponges miR-223 and Promotes the Proinflammatory Vascular Smooth Muscle Cell Transition

Researchers identified and functionally validated a long noncoding RNAs using human atherosclerotic plaques. Human aortic samples were obtained from patients who underwent aortic surgery, and tissues were classified according to atherosclerotic plaques.
[Experimental & Molecular Medicine]
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Dapagliflozin Attenuates Pressure Overload-Induced Myocardial Remodeling in Mice via Activating SIRT1 and Inhibiting Endoplasmic Reticulum Stress

In vitro, scientists found that DAPA inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II (Ang II)-treated cardiomyocytes.
[Acta Pharmacologica Sinica]
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Lymphangion-Chip: A Microphysiological System Which Supports Co-Culture and Bidirectional Signaling of Lymphatic Endothelial and Muscle Cells

A fabrication technique was developed to create a lymphangion-chip. This organ-on-chip consisted of co-culture of a monolayer of endothelial lumen surrounded by multiple and uniformly thick layers of muscle cells.
[Lab On A Chip]
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Nicotinamide Promotes Cardiomyocyte Derivation and Survival through Kinase Inhibition in Human Pluripotent Stem Cells

Researchers showed that nicotinamide played multiplex roles in mesoderm differentiation of human ESCs. Nicotinamide promoted cardiomyocyte fate from mesoderm progenitor cells, and suppressed the emergence of other cell types.
[Cell Death & Disease]
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Neurana Pharmaceuticals Completes Patient Enrollment in Phase III RESUME-1 Study

Neurana Pharmaceuticals, announced it has completed enrollment of its 1,000 patient Phase III RESUME-1 Study of tolperisone for the relief of muscle spasm associated with acute, painful musculoskeletal conditions.
[Neurana Pharmaceuticals. Inc.]
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The Cardiomyocyte Disrupts Pyrimidine Biosynthesis in Non-Myocytes to Regulate Heart Repair

Scientists showed that rescue of pyrimidine biosynthesis by administration of uridine or by genetic targeting of ENPP1/AMP pathway enhanced repair after cardiac injury.
[Journal of Clinical Investigation]
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Cardiomyocyte-GSK-3β Deficiency Induces Cardiac Progenitor Cell Proliferation in the Ischemic Heart through Paracrine Mechanisms

Researchers identified the potential roles of glycogen synthase kinase-3β, a critical regulator of cell proliferation and differentiation, in cardiac progenitor cell proliferation post-myocardial infarction.
[Journal of Cellular Physiology]
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Positive Feedback Loop of lncRNA SNHG1/miR-16-5p/GATA4 in the Regulation of Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury

The authors explored the role and molecular mechanism of lncRNA small nucleolar RNA host gene 1 (SNHG1) in ischemic cardiomyocyte injury.
[Molecular Medicine Reports]
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BAF Complexes Drive Proliferation and Block Myogenic Differentiation in Fusion-Positive Rhabdomyosarcoma

Investigators investigated the contributions of chromatin regulatory complexes to fusion positive RMS (FP-RMS) tumor maintenance. They defined the mSWI/SNF functional repertoire in FP-RMS.
[Nature Communications]
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Bi-Phasic Effect of Gelatin in Myogenesis and Skeletal Muscle Regeneration

Researchers elaborate on a bi-phasic effect of gelatin in skeletal muscle regeneration, mediated by hormetic effects of reactive oxygen species.
[Disease Models & Mechanisms]
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