Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

SMCHD1 Activates the Expression of Genes Required for the Expansion of Human Myoblasts

[Nucleic Acids Research] Genomic and transcriptomic experiments determined that structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) associated with enhancers of genes controlling cell cycle to activate their expression.

The IRE1α/XBP1 Signaling Axis Drives Myoblast Fusion in Adult Skeletal Muscle

[EMBO Reports] Researchers demonstrated that inducible deletion of inositol requiring enzyme 1α (IRE1α) in satellite cells of mice impaired skeletal muscle regeneration through inhibiting myoblast fusion.

Differential Responses to Thrombospondin-1 and PDGF-BB in Smooth Muscle Cells from Atherosclerotic Coronary Arteries and Internal Thoracic Arteries

[Scientific Reports] Internal thoracic arteries smooth muscle cells (SMC) from three distinct donors and atherosclerotic coronary artery SMC from three distinct donors were grown to sub-confluence and growth arrested for 48 hours.

Niclosamide Modulates Phenotypic Switch and Inflammatory Responses in Human Pulmonary Arterial Smooth Muscle Cells

[Molecular and Cellular Biochemistry] Cell proliferation assay showed that niclosamide inhibited PDGF-BB induced proliferation of human pulmonary arterial smooth muscle cells in a dose-dependent manner.

The E2F Family: A Ray of Dawn in Cardiomyopathy

[Molecular and Cellular Biochemistry] The authors describe the structural and functional characteristics of the E2F family and its role in cardiomyocyte processes, with a focus on how E2Fs are associated with the onset and development of cardiomyopathies.

Satellos Announces Submission of Regulatory Filing to Commence a Phase I Clinical Trial with SAT-3247

[Satellos Bioscience Inc. (Businesswire)] Satellos Bioscience Inc. announced submission of a clinical research proposal to a Human Research Ethics Committee in Australia seeking regulatory authorization to conduct a first-in-human Phase I clinical trial of SAT-3247.

EPAC1 and 2 Inhibit K+ Currents via PLC/PKC and NOS/PKG Pathways in Rat Ventricular Cardiomyocytes

[American Journal of Physiology-Cell Physiology] Researchers assessed the role of Exchange Protein directly Activated by cAMP (EPAC) 1 and 2 in the decrease of repolarizing steady state K+ current and to investigate the underlying signalling pathways.

Hypoxic Extracellular Vesicles from hiPSCs Protect Cardiomyocytes from Oxidative Damage by Transferring Antioxidant Proteins and Enhancing Akt/Erk/NRF2 Signaling

[Cell Communication and Signaling] Extracellular vesicles were isolated by ultrafiltration combined with size exclusion chromatography, followed by characterization by nanoparticle tracking analysis, atomic force microscopy and Western blot methods.

Nicotinamide N-Methyltransferase Inhibition Mimics and Boosts Exercise-Mediated Improvements in Muscle Function in Aged Mice

[Scientific Reports] Since human hallmarks of sarcopenia were recapitulated in aged mice, researchers treated mice from 22 to 24 months of age with Nicotinamide N-methyltransferase inhibitor, intensive exercise, or a combination of both, and compared skeletal muscle adaptations.

KLF13 Restrains Dll4-Muscular Notch2 Axis to Improve the Muscle Atrophy

[Journal of Cachexia Sarcopenia and Muscle] The effects of gene knockdown and pharmacological targeting of Krüppel-like factor 13 (KLF13) on skeletal muscle atrophy were investigated using cell-based and animal models.

FOXO-Regulated DEAF1 Controls Muscle Regeneration through Autophagy

[Autophagy] Investigators identified a new regulator of muscle regeneration, deformed epidermal autoregulatory factor-1 (Deaf1) – a transcriptional factor downstream of forkhead box O (foxo) signaling.

Epigenetic Control of Skeletal Muscle Atrophy

[Cellular & Molecular Biology Letters] Scientists discuss how epigenetic modifications change during the process of skeletal muscle atrophy, the molecular mechanisms by which epigenetic regulatory proteins control skeletal muscle atrophy, and assess their translational potential.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.