The authors explored the PDGF-PDGFR gene expression changes and their involvement in skeletal muscle myogenesis and myogenic fate.
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Alizarin red staining and quantification of calcium content showed that spermidine treatment markedly reduced mineral deposition in both rat and human vascular smooth muscle cells (VSMCs) under osteogenic conditions.
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Researchers analyzed the roles of puerarin and LncRNA ANRIL in myocardial ischemia–reperfusion injury. After cell transfection, the effects of overexpressed and knockdown of ANRIL on cardiomyocytes and H/R-injured cardiomyocytes were examined by rescue experiments.
[Cell and Tissue Research]
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Scientists investigated yes-associated protein (YAP) activity using disease-specific induced pluripotent stem cell derived cardiomyocytes in Duchenne muscular dystrophy.
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The authors review recent advances that elucidate the relationship between myonuclear numbers and establishment of myofiber size, and discuss how this new information refines our understanding of the concept of myonuclear domains, the cytoplasmic volumes that each resident myonucleus can support.
[Seminars in Cell & Developmental Biology]
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Scientists identified mRNAs bound to and regulated by Cpeb4 in cardiomyocytes. Cpeb4 regulated cardiac remodeling by differential expression of transcription factors.
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Riechert, E., Kmietczyk, V., Stein, F., Schwarzl, T., Sekaran, T., Jürgensen, L., Kamuf-Schenk, V., Varma, E., Hofmann, C., Rettel, M., Gür, K., Ölschläger, J., Kühl, F., Martin, J., Ramirez-Pedraza, M., Fernandez, M., Doroudgar, S., Méndez, R., Katus, H. A., … Völkers, M. (2021). Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes. Cell Reports, 35(6). https://doi.org/10.1016/j.celrep.2021.109100 Cite
Using three-dimensional structured illumination microscopy, scientists observed that the mitochondrial protein Mitofusin-2 (Mfn2) co-localized at the plasma membrane with VE-cadherin and β-catenin in endothelial cells during homeostasis.
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Kim, Y.-M., Krantz, S., Jambusaria, A., Toth, P. T., Moon, H.-G., Gunarathna, I., Park, G. Y., & Rehman, J. (2021). Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling. Nature Communications, 12(1), 2736. https://doi.org/10.1038/s41467-021-23047-6 Cite
Researchers demonstrated that the distinct early telomere shortening of diseased muscle stem cell in both mice and young Duchenne muscular dystrophy patients was associated with aberrant NF-κB activation.
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Scientists consider a gamut of attractive possibilities for modifying inflammation in atherosclerosis, including targeting pivotal inflammatory pathways such as the inflammasomes, inhibiting cytokines, manipulating adaptive immunity and promoting pro-resolution mechanisms.
[Nature Reviews Drug Discovery]
Researchers reported a three-dimensional primary human skeletal muscle model of infantile-onset Pompe disease that recapitulated hallmark pathological features including reduced GAA enzyme activity, elevated glycogen content and lysosome abundance, and increased sensitivity of muscle contractile function to metabolic stress.
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Wang, J., Zhou, C. J., Khodabukus, A., Tran, S., Han, S.-O., Carlson, A. L., Madden, L., Kishnani, P. S., Koeberl, D. D., & Bursac, N. (2021). Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-021-02059-4 Cite
Scientists investigated the beneficial effects of endurance training on growth Associated Protein 43 (GAP-43) and Kinesin Family Member 5B (KIF5B) expression in gastrocnemius muscle of streptozotocin – induced diabetic rats.