Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Astaxanthin Alleviates PM2.5-Induced Cardiomyocyte Injury via Inhibiting Ferroptosis

[Cellular & Molecular Biology Letters] In vitro experiments, the H9C2 cells were subjected to pretreatment with varying concentrations of astaxanthin, and then cardiomyocyte injury model induced by PM2.5 was established.

Skeletal Muscle-Secreted DLPC Orchestrates Systemic Energy Homeostasis by Enhancing Adipose Browning

[Nature Communications] By performing lipidomic analysis in muscle-conditioned medium and serum, the authors identified 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) as a muscle-released lipid that was responsible for MyoD-orchestrated body energy homeostasis in male Myod knockout mice.

All-Trans Retinoic Acid and Dexamethasone Regulate Phagocytosis-Related Gene Expression and Enhance Dead Cell Uptake in C2C12 Myoblast Cells

[Scientific Reports] Researchers investigated the in vitro phagocytic capacity of the C2C12 mouse myoblast cell line. RNA sequencing data were analyzed to determine the level and changes of phagocytosis-related gene expression during the differentiation process of C2C12 cells.

Smooth Muscle–Derived Adventitial Progenitor Cells Direct Atherosclerotic Plaque Composition Complexity in a Klf4-Dependent Manner

[JCI Insight] The authors confirmed that vascular smooth muscle–derived adventitial progenitor cells–derived cells localized throughout the vessel wall and atherosclerotic plaques, where they primarily differentiated into fibroblasts, smooth muscle cells, or remained in a stem-like state.

Piezo1-Mediated Regulation of Smooth Muscle Cell Volume in Response to Enhanced Extracellular Matrix Rigidity

[British Journal of Pharmacology] Human aortic-vascular smooth muscle cells were seeded onto polyacrylamide hydrogels whose rigidity mimicked either healthy or aged/diseased aortae.

Aerobic Exercise Improves BKCa Channel-Mediated Vasodilation in Diabetic Vascular Smooth Muscle via AMPK/Nrf2/HO-1 Pathway

[Acta Diabetologica] Control m/m mice and diabetic db/db mice were randomly assigned to sedentary groups and exercise training groups. Mice in exercise groups underwent training sessions lasting for 12 weeks, with a speed of 12 m/min for 60 min, five times per week.

Potential Regulatory Role of PGC-1α within the Skeletal Muscle during Metabolic Adaptations in Response to High-Fat Diet Feeding in Animal Models

[Pflugers Archiv-European Journal Of Physiology] The authors suggest the causal relationship between peroxisome proliferator–activated receptor γ coactivator-1α (PGC-1α) regulation and effective modulations of mitochondrial biogenesis and metabolic flexibility during the different stages of disease development.

ORYZON Awarded with a Grant for ORY-4001 from the ALS Association in the US

[Oryzon Genomics] Oryzon Genomics, announced the start of a preclinical collaboration with the ALS Association. The Association has awarded Oryzon a 498,690 USD grant to support the regulatory preclinical development of ORY-4001.

SARS-CoV-2 Spike Receptor-Binding Domain Is Internalized and Promotes Protein ISGylation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

[Scientific Reports] Researchers investigated the direct effects of spike receptor-binding domain on human cardiomyocytes differentiated from induced pluripotent stem cells.

Lactate and Immunomagnetic-Purified hiPSC-Derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs

[JCI Insight] Scientists determined if use of lactate relative to magnetic antibody-based cell sorting-purified human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes impacted the properties of resulting hiPSC-engineered cardiac tissues.

Dbh+ Catecholaminergic Cardiomyocytes Contribute to the Structure and Function of the Cardiac Conduction System in Murine Heart

[Nature Communications] Investigators reported a previously unrecognised population of cardiomyocytes expressing dopamine beta-hydroxylase (Dbh) gene encoding dopamine beta-hydroxylase in murine heart.

Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects

[Cell] The authors established a human cardioid platform that recapitulated the development of all major embryonic heart compartments, including right and left ventricles, atria, outflow tract, and atrioventricular canal.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.