Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

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Entos Pharmaceuticals and the L-CMD Research Foundation Collaborate to Develop Curative Therapy for LMNA-Related Congenital Muscular Dystrophy

April 20, 2026

[Entos Pharmaceuticals, Inc. ] Entos Pharmaceuticals, Inc. announced a collaboration with the L-CMD Research Foundation, a nonprofit that urgently translates scientific research into treatments for LMNA-related congenital muscular dystrophy (L-CMD).

MARCH2 Prevents Doxorubicin-Induced Cardiomyopathy by Stabilizing NR1H2 and Promoting Clearance of Apoptotic Cardiomyocytes

April 20, 2026

[Nature Communications] Scientists found that MARCH2 expression is significantly reduced in cardiac macrophages from doxorubicin-induced cardiomyopathy (DiCM) mice and human dilated cardiomyopathy patients.

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

April 20, 2026

[Advanced Healthcare Materials] The authors investigated the role of surface charge and synergistic mechano-electrical stimulation of piezoelectric poly(vinylidene fluoride) on the behaviour of H9c2 cardiac cells.

Arachidonate Lipoxygenase 5 Metabolism Axis Promoting Ferroptosis: A Potential Druggable Target for Doxorubicin-Induced Cardiomyopathy

April 20, 2026

[British Journal of Cancer] Researchers investigated the role of the ALOX5 metabolism axis in doxorubicin-induced cardiomyopathy and to elucidate its underlying mechanism using genetic and pharmacological approaches.

Dystrophins DP71 and DP427 Determine Cell Viability during Proliferation and Myofibre Differentiation

April 20, 2026

[Cell Death & Disease] Scientists investigated the roles of DP427 and DP71 during cell proliferation and fibre differentiation. They included paralogous utrophins in our analyses, particularly the UP395 isoform, owing to its presence in muscle and its partial ability to compensate for the lack of DP427.

TAK1 Is a Key Regulator of Oncogenic Signaling and Differentiation Blockade in Rhabdomyosarcoma

April 20, 2026

[Oncogene] Investigators showed that transforming growth factor β-activated kinase 1 (TAK1) expression and activity are markedly elevated in rhabdomyosarcoma cell lines and patient tumor specimens.

TGFβ1-Loaded Extracellular Matrix Hydrogels Promote Skeletal Muscle Stem Cell Regeneration via m6a-Mediated Integrin-ERK Signaling

April 20, 2026

[Journal of Translational Medicine] Researchers revealed a novel m6A-mediated pathway that integrates biochemical (TGFβ1) and mechanical signals to direct skeletal muscle stem cells fate

Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics

April 20, 2026

[Circulation] To achieve precise manipulation of arterial smooth muscle cell (ASMCs) in vivo, researchers combined alleles for Cspg4-Dre and rox-Stop–containing Acta2-CreER, generating a mouse line with Cre activity exclusively in ASMCs.

PDK4 Drives Abdominal Aortic Aneurysm by Promoting Smooth Muscle Cell Metabolic Reprogramming and NLRP3-Mediated Pyroptosis

April 20, 2026

[Nature Communications] Investigators showed that pyruvate dehydrogenase kinase 4 (PDK4), a key metabolic regulator, is upregulated in human and mouse abdominal aortic aneurysm tissues.

Molecular Basis of Muscle Wasting and Emerging Therapeutic Strategies Targeting Degenerative Muscle Disorders

April 20, 2026

[Experimental Cell Research] Scientists summarize current knowledge of the molecular mechanisms underlying muscle degeneration and discusses emerging therapeutic strategies that hold promise for effective muscle regeneration.

PGK1 Drives Cardiac Hypertrophy by Regulating the Vimentin/PI3K/Akt Pathway

April 6, 2026

[Circulation Research] Researchers highlighted a critical role for PGK1 (phosphoglycerate kinase 1) in myocardial hypertrophy, with downstream activation of the vimentin/PI3K/Akt/ferroptosis pathway.

Cardiomyocyte-Derived GPX4 Stabilizes BNIP3 to Facilitate Mitophagy and Mitigate Myocardial Ischemia/Reperfusion Injury

April 6, 2026

[Nature Communications] Scientists defined the role of the GPX4/BNIP3/USP20 complex in myocardial ischemia/reperfusion injury and uncovered a mechanism linking GPX4 to ferroptosis-related mitochondrial damage.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.