Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

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Intramyocardial Injection of Allogeneic Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Advanced Ischemic Heart Failure: An Early-Stage Randomized Trial

August 24, 2026

[Nature Medicine] Scientists conducted the HEAL-CHF trial, in which patients with advanced heart failure with reduced ejection fraction were randomized to receive intramyocardial injections of allogeneic hiPSC-derived cardiomyocytes or were uninjected.

Potassium-Selective Nanoelectrode Arrays for Single-Cell Profiling of Human iPSC-Derived Cardiomyocytes

August 24, 2026

[ACS Nano] Researchers developed KINESIS (K⁺-Ion Nano-Electrode Selective Interface System), a potassium-selective nanoelectrode platform that enables label-free, single-cell monitoring of K⁺ dynamics in hiPSC-derived cardiomyocytes for cardiotoxicity testing and disease modeling.

Free Fatty Acid Receptor 4 in Cardiac Myocytes Ameliorates Ischemic Cardiomyopathy

August 24, 2026

[Cardiovascular Research] Investigators showed that Ffar4 protects cardiac muscle cells from ischemic injury by preserving mitochondrial function and cGMP signaling, helping prevent cardiac dysfunction after ischemia-reperfusion.

PP2Acα Regulates the Hippo-YAP Signaling Axis to Promote Cardiac Regeneration and Alleviate Myocardial Infarction

August 24, 2026

[Journal of Molecular and Cellular Cardiology] The authors showed that protein phosphatase 2A (PP2A)cα promotes cardiomyocyte proliferation and heart regeneration by activating Hippo–YAP signaling, revealing a potential therapeutic target for cardiac repair after myocardial infarction.

One-Step Coaxial Bioprinting of Aligned and Vascularized 3D Skeletal Muscle Constructs

August 24, 2026

[Biofabrication] Scientists developed a one-step coaxial bioprinting strategy to create aligned, vascularized 3D skeletal muscle constructs, advancing muscle regeneration, disease modeling, and drug screening.

Flexible 3D-Printed Piezoelectric and Bioinstructive Platforms for Skeletal Muscle Development and Organization

August 24, 2026

[ACS Applied Materials & Interfaces] Investigators developed a myogenic platform that provides a comprehensive set of bioactive cues, including bioelectrical cues that can be delivered wirelessly, to promote skeletal muscle development.

Immortalized Smooth Muscle Cells Enhance In Vitro Vasculogenesis

August 24, 2026

[Angiogenesis] Researchers developed a robust co-culture system of HUVECs and smooth muscle cells to generate stable vascular networks capable of maintaining tissue viability over extended periods.

Biomolecular Condensates As Dynamic Regulators of Musculoskeletal Homeostasis, Disease, and Therapeutic Challenges

August 24, 2026

[Bone Research] Scientists examine how biomolecular condensates and liquid-liquid phase separation-related mechanisms have been implicated in osteoporosis, osteoarthritis, skeletal muscle atrophy, bone and soft tissue sarcomas, and neuromusculoskeletal diseases.

Precision BioSciences Commences Dosing in Phase I/II FUNCTION-DMD Study

August 24, 2026

[Precision BioSciences, Inc.] Precision BioSciences, Inc. announced the dosing of the first patient in August in the Phase I/II FUNCTION-DMD clinical trial evaluating PBGENE-DMD for the treatment of Duchenne muscular dystrophy (DMD).

UBC Medicine Researchers Awarded More Than $39 Million in CIHR Funding

August 17, 2026

[The University of British Columbia] UBC Faculty of Medicine researchers have been awarded more than $39 million in federal funding through the Canadian Institutes of Health Research (CIHR) Project Grant: Spring 2026 competition.

Mechanical Unloading Promotes Adult Cardiomyocyte Proliferation through Epicardial NRG1-ERBB4 Signaling

August 10, 2026

[Nature Cardiovascular Research] Scientists used a heterotopic heart transplantation model, in which the donor heart is vascularized but nonpumping, to show that mechanical unloading induces adult cardiomyocyte proliferation, revealed by Ki67-based and mosaic analysis with double markers lineage tracing.

Cardiomyocyte OTUD7b Drives Diabetic Cardiomyopathy via Deubiquitinating and Stabilizing TAK1

August 10, 2026

[Acta Pharmacologica Sinica] The authors identified that OTU domain-containing protein 7B (OTUD7b) expression was significantly elevated in cardiomyocytes from both type 1 and type 2 diabetic mouse hearts.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.