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Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
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Mechanical Unloading Promotes Adult Cardiomyocyte Proliferation through Epicardial NRG1-ERBB4 Signaling
[Nature Cardiovascular Research] Scientists used a heterotopic heart transplantation model, in which the donor heart is vascularized but nonpumping, to show that mechanical unloading induces adult cardiomyocyte proliferation, revealed by Ki67-based and mosaic analysis with double markers lineage tracing.
Cardiomyocyte OTUD7b Drives Diabetic Cardiomyopathy via Deubiquitinating and Stabilizing TAK1
[Acta Pharmacologica Sinica] The authors identified that OTU domain-containing protein 7B (OTUD7b) expression was significantly elevated in cardiomyocytes from both type 1 and type 2 diabetic mouse hearts.
Ascorbic Acid Attenuates Obesity Induced Myogenic Impairment in C2C12 Cells
[Life Sciences] Investigators aimed of the study was to rescue obesity induced skeletal muscle atrophy with ascorbic acid in vitro. Their findings suggest that ascorbic acid alleviates adipocyte-derived inflammatory stress and protects against myotube atrophy.
LXR/RXR Activation Mitigates Ferroptosis in Diabetic Cardiomyocytes by Regulating Calpain1 via Calpastatin
[Biochemical Pharmacology] High-fat diet/streptozotocin-induced Type 2 Diabetes Mellitus mouse models and high glucose and high fat-exposed cardiomyocytes were used to assess the impact of Liver X Receptor (LXR) activation on myocardial injury and ferroptosis.
Loss of the Coronary Artery Disease Risk Gene LMOD1 in Vascular Smooth Muscle Cells Triggers Rapid-Onset Coronary Atherosclerosis
[Circulation] Researchers showed that loss of LMOD1 in vascular smooth muscle cells triggers rapid coronary atherosclerosis, revealing a protective role for LMOD1 in coronary artery health.
Long Non-Coding RNA SNHG6 Promotes the Proliferation of PASMCs Cells through the miR-429/DUSP1 Axis during Early/Subacute Vascular Responses to Pulmonary Embolism
[Molecular and Cellular Biochemistry] Scientists showed that the lncRNA SNHG6 promotes pulmonary arterial smooth muscle cell proliferation through the miR-429/DUSP1 axis, revealing a potential mechanism underlying vascular remodeling after pulmonary embolism.
Temperature Dependence of Activation of Thick and Thin Filaments in Skeletal and Cardiac Muscles
[Journal of Muscle Research and Cell Motility] Investigators discuss the differential effects of heating on the skeletal vs. cardiac contractile system, focusing especially on the temperature-dependent shift of the “on-off” equilibrium of the thin filament state in sarcomeres.
Emory Biophysicist Shashank Shekhar’s Research into Tiny Cellular Force Generators Nets Two Major Federal Awards
[Emory University] Dr. Shekhar won two major funding awards in recognition of the huge impact of his work to understand the tiny threads: the elite National Science Foundation Faculty Early Career Development Program grant and renewal of a National Institutes of Health Maximizing Investigators’ Research Award.
Progressing Regenerative Medicine: Integrating Bioprinting Platforms for Stem Cell Applications
[Stem Cell International] Investigators critically evaluate bioprinting strategies tailored for stem cell applications, including the selection of stem cell sources, bioink formulation, crosslinking methodologies, and dynamic culture systems.
Lexicon Pharmaceuticals Completes Enrollment of Pivotal Phase 3 SONATA-HCM Study of Sotagliflozin in Symptomatic Non-Obstructive and Obstructive Hypertrophic Cardiomyopathy (HCM)
[Lexicon Pharmaceuticals, Inc. ] Lexicon Pharmaceuticals, Inc. announced that randomization of patients has been completed in the pivotal Phase III clinical trial evaluating sotagliflozin in patients with non-obstructive and obstructive hypertrophic cardiomyopathy.
Single-Cell Multiomics and Chromatin Structure Reveal Gene-Regulatory Dynamics in Heart Failure
[Science] Investigators constructed a multimodal cell atlas of 36 human hearts spanning atrial and ventricular chambers, cataloging major cardiac cell types and their associated disease states.
Small Extracellular Vesicles from Cardiomyocytes Activate Microglia Aggravating HFpEF
[Circulation Research] Researchers revealed that heart failure with preserved ejection fraction (HFpEF) prompts cardiomyocytes to release small extracellular vesicles enriched with miR-200c-3p, leading to hypothalamic inflammation and evoking sympathetic outflow, which in turn exacerbates cardiac dysfunction.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
