Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

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Progressing Regenerative Medicine: Integrating Bioprinting Platforms for Stem Cell Applications

July 29, 2026

[Stem Cell International] Investigators critically evaluate bioprinting strategies tailored for stem cell applications, including the selection of stem cell sources, bioink formulation, crosslinking methodologies, and dynamic culture systems.

Lexicon Pharmaceuticals Completes Enrollment of Pivotal Phase 3 SONATA-HCM Study of Sotagliflozin in Symptomatic Non-Obstructive and Obstructive Hypertrophic Cardiomyopathy (HCM)

July 28, 2026

[Lexicon Pharmaceuticals, Inc. ] Lexicon Pharmaceuticals, Inc. announced that randomization of patients has been completed in the pivotal Phase III clinical trial evaluating sotagliflozin in patients with non-obstructive and obstructive hypertrophic cardiomyopathy.

Single-Cell Multiomics and Chromatin Structure Reveal Gene-Regulatory Dynamics in Heart Failure

July 28, 2026

[Science] Investigators constructed a multimodal cell atlas of 36 human hearts spanning atrial and ventricular chambers, cataloging major cardiac cell types and their associated disease states.

Small Extracellular Vesicles from Cardiomyocytes Activate Microglia Aggravating HFpEF

July 28, 2026

[Circulation Research] Researchers revealed that heart failure with preserved ejection fraction (HFpEF) prompts cardiomyocytes to release small extracellular vesicles enriched with miR-200c-3p, leading to hypothalamic inflammation and evoking sympathetic outflow, which in turn exacerbates cardiac dysfunction.

LMNA P.H222P Mutation Causes Contractile Dysfunction via Impaired Mitochondrial Calcium Uptake in Human Cardiac Laminopathy

July 28, 2026

[Cardiovascular Research] The authors established a direct mechanistic link between nuclear envelope dysfunction and impaired mitochondrial function, and highlight the mitochondrial calcium uniporter complex as a potential therapeutic target in LMNA-related cardiomyopathy.

FAP-Derived CCL2 Is Required for Adequate Monocyte/Macrophage Infiltration to Support Acute Skeletal Muscle Injury Repair

July 28, 2026

[iScience] Investigators identified fibro/adipogenic progenitors (FAPs) as the primary source of CCL2 in acutely injured muscle, where the pro-inflammatory subcluster of FAPs expanded rapidly and expressed the highest level of CCL2.

Molecular Mechanisms Underlying FCCP-Induced Mitophagyin Human Airway Smooth Muscle Cells

July 28, 2026

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Researchers hypothesized that, in human airway smooth muscle cells, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP)-induced mitochondrial depolarization activates the PINK1-Parkin-mediated mitophagy pathway, culminating in the clearance of damaged mitochondria.

Smooth Muscle Cell Spheroids As 3D Model of Phenotypic Plasticity and Matrix Deposition Revealed by 2D-3D Proteomics

July 28, 2026

[Scientific Reports] Researchers established a scaffold-free 3D spheroid model of murine and human aortic vascular smooth muscle cells derived from heart failure patients to mimic their multicellular organization, cell plasticity, and interactions with the extracellular matrix.

Single-Cell Resolution of Skeletal Muscle Aging: Current Paradigms and Perspectives

July 28, 2026

[Ageing Research Reviews] Scientists summarize current progress in single-cell technology with respect to skeletal muscle aging. They focused on specific molecular characteristics and interaction networks of muscle fiber, satellite, and immune cells during aging.

The Local-Systemic Axis of the Skeletal Muscle Secretome

July 28, 2026

[Trends In Endocrinology and Metabolism] Using skeletal muscle and endurance exercise as a model system, scientists defined a local–systemic secretome axis shaped by spatial organization, stimulus-specific programs, temporal dynamics, extracellular processing, and paracrine circuitry.

NWO Awards Ten Veni Grants to Promising UM Researchers

July 22, 2026

[Maastricht University] As many as ten young UM researchers have been awarded a Veni grant worth up to €320,000 from the Netherlands Organisation for Scientific Research (NWO).

Urolithin A Activates Mitophagy via the AMPK-mTOR Axis and Modulates the Gut-Ceramide Axis to Ameliorate Cardiac Remodeling in HFpEF

July 13, 2026

[Experimental & Molecular Medicine] Scientists investigated whether urolithin A (UA) , a gut microbiome-derived mitophagy-activating compound, can ameliorate heart failure with preserved ejection fraction (HFpEF). In vitro and in vivo experiments, together with multi-omics analyses, showed that UA alleviated diastolic dysfunction, cardiac hypertrophy, and fibrosis in HFpEF mice.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.