Cancer Stem Cell News
Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Subscribe|Follow Us On
A Muscle-Enriched Mitochondrial Protein Regulates Postnatal Heart Growth through Mitonuclear Ubiquinone-PPAR Signaling
[Proceedings of the National Academy of Sciences of the United States of America] By integrating mitochondrial proteome annotations with mouse and human transcriptomic datasets, scientists identified Coenzyme Q10a, a striated muscle-enriched mitochondrial protein, as a regulator of postnatal cardiac growth.
Cardiomyocyte-Enriched OTUD5 Alleviates Pathological Myocardial Hypertrophy by Deubiquitinating STAT3 and Modulating the STAT3-PGC-1α Axis
[Experimental & Molecular Medicine] Researchers investigated the role and molecular mechanisms of OTUD5 in pathological cardiac hypertrophy. OTUD5 expression is greatly increased in cardiomyocytes from hypertrophic hearts.
Structural and Functional Remodeling of Large-Scale Cardiac Tubes
[Biofabrication] Investigators engineered large tubular constructs (6 × 1 cm) from hiPSC-derived cardiomyocytes and human foreskin fibroblasts via a rotating mold technology in four independent experiments.
Low-Dose Juglone Attenuates Pressure Overload-Induced Cardiac Hypertrophy through Lys207-Dependent FoxO1 Activation and Mitochondrial Protection
[Pharmacological Research] Scientists investigated the efficacy, safety window, and redox-regulatory mechanism of juglone, a naturally occurring 5-hydroxy-1,4-naphthoquinone.
Restoration of Cyclin A2 by Glabridin Reverses Pathological Cell Cycle Arrest and Drives Cardiac Repair in HFpEF
[Acta Pharmacologica Sinica] The authors identified aberrant cardiomyocyte cell cycle arrest as a previously unrecognized pathological driver of heart failure with preserved ejection fraction (HFpEF) that hinders tissue repair.
The SGLT2 Inhibitor Empagliflozin Directly Binds Cardiac JNK3, Uncouples c-Jun/c-Fos Signaling, and Confers Cardioprotection in Diabetic Cardiomyopathy
[Diabetes & Metabolism Journal] Researchers aimed to identify a direct cardiac target of empagliflozin and define the downstream signaling mechanisms mediating its cardioprotective effects in diabetic cardiomyopathy.
Systems Analysis Reveals Neuregulin-1 Control of Cardiomyocyte Size and Shape Mediated by Distinct PI3K and p38 Pathways
[Journal of Molecular and Cellular Cardiology] Investigators combined high-content morphological profiling, phospho-protein arrays, and systems modeling to characterize the diverse forms of hypertrophy induced by angiotensin II, endothelin-1, insulin growth factor-1, and neuregulin-1.
Circadian Disruption Exacerbates Alcohol-Induced Cardiac Injury through Impaired Cellular Quality Control and Increased Cardiomyocyte Death
[Molecular and Cellular Biochemistry] Scientists performed RNA-sequencing and transcriptomic analysis on hearts from C57BL/6 J mice exposed to alcohol for ten weeks and collected at two distinct circadian time points.
Exercise Improves Heart Failure by Regulating Cardiomyocyte Autophagy via the ILF3/lncRNA NEAT1 Axis
[Molecular and Cellular Biochemistry] Researchers aimed to investigate whether exercise can influence heart failure progression by regulating expression of the lncRNA NEAT1, and to elucidate its molecular mechanisms.
An Integrative Transcriptomic Atlas of ALS and Aging Skeletal Muscle Defines Shared and Distinct Molecular Programs of Degeneration
[Proceedings of the National Academy of Sciences of the United States of America] Researchers used the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model and wild-type mice across the lifespan to generate an integrated single-nucleus transcriptomic atlas of skeletal muscle, mapping changes associated with ALS and aging.
Titin Extension Explains Residual Force Enhancement in Skeletal Muscle
[Proceedings of the National Academy of Sciences of the United States of America] To test whether titin may be responsible for residual force enhancement, investigators used multiple titin immunolabels on single isolated myofibrils to approximately track the migration of individual titin segments in real-time.
Effect of Serum on Smooth Muscle Cell Phenotype in 3D Tissue-Engineered Microvessels
[ACS Biomaterials Science & Engineering] Researchers reported a 3D microfluidic-based tissue-engineered model with human brain smooth muscle cells (SMCs) forming a microvessel within a collagen I hydrogel. Using this platform, they demonstrated that serum-free culture conditions are essential to prevent SMC overproliferation and maintain vessel patency.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
