Based on a comprehensive investigation involving pancreatic cancer (PC) patient samples, murine models of PC progression, and loss and gain of function studies, researchers reported a previously undescribed critical role of microtubule-associated serine/threonine-protein kinase-like (MASTL) in promoting cancer malignancy and therapy resistance.
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Scientists employed an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across a panel of patient-derived pancreatic ductal adenocarcinoma models.
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A HepG2 cell line, which inducibly expresses ferroportin-GFP, was established to test the ability of siRNAs directed against components of the ubiquitin system to prevent BMP6- and exogenous hepcidin-induced ferroportin degradation.
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Promising pharmacological advances in insulin therapy include the refinement of extremely rapid insulin analogs, alternate insulin-delivery routes, liver-selective insulins, add-on drugs that enhance insulin effect, and glucose-responsive insulin molecules.
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Researchers introduced an intact human chromosome 3 into the human PK9 and murine LTPA pancreatic cancer cell lines using microcell-mediated chromosome transfer.
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LSI Director Dr. Josef Penninger and Drs. David Long, Luigi Gnudi, and Karen Price in the UK are recipients of a UK-Canada Diabetes Research Team Grant entitled “Bridging the gap to translation by understanding and preventing diabetic vascular complications using human organoid culture” as part of the 100 Years of Insulin initiative.
[The University of British Columbia]
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Researchers identified never in mitosis gene A-related kinase 2 (NEK2) as a prognostic factor in immunologically “hot” pancreatic cancer, involved in the onset and development of pancreatic tumors in an immune-dependent manner.
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Researchers investigated the effects of different doses of metformin on AQP7 expression and explored the possible mechanism of its protective effects in the pancreatic islets.
[Journal of Biological Chemistry]
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Scientists demonstrated that tripartite motif (TRIM) expression was elevated in pancreatic ductal adenocarcinomas tissues, and this elevated expression was associated with a poor prognosis.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
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Scientists investigated the role of ANGPTL4 in KRASG12D-induced acinar-to-ductal metaplasia, pancreatic intraepithelial neoplasia formation, and pancreatic ductal adenocarcinoma maintenance.
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Scientists determined the effects of miR‑7515 on pancreatic cancer cell proliferation, invasion and migration in vitro and in vivo, and investigated its underlying molecular mechanism using bioinformatics, double luciferase assay and western blotting.
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