Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell

Scientists confirmed the remarkable potential of Glucagon Like Peptide 1 Receptor agonist conjugation for the delivery of antisense oligonucleotides to pancreatic beta cell by effectively knocking down islet amyloid polypeptide mRNA, a potential proapoptotic target, in mice.
[Journal of the American Chemical Society]
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell | Journal of the American Chemical Society. (n.d.). Retrieved February 26, 2021, from https://pubs.acs.org/doi/10.1021/jacs.0c12043 Cite
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H2A.Z Overexpression Suppresses Senescence and Chemosensitivity in Pancreatic Ductal Adenocarcinoma

Scientists demonstrated that the histone variant H2A.Z was highly expressed in PDAC cell lines and PDAC patients and that its overexpression correlated with poor prognosis.
[Oncogene]
Ávila-López, P. A., Guerrero, G., Nuñez-Martínez, H. N., Peralta-Alvarez, C. A., Hernández-Montes, G., Álvarez-Hilario, L. G., Herrera-Goepfert, R., Albores-Saavedra, J., Villegas-Sepúlveda, N., Cedillo-Barrón, L., Montes-Gómez, A. E., Vargas, M., Schnoor, M., Recillas-Targa, F., & Hernández-Rivas, R. (2021). H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01664-1 Cite
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Sialic Acids in Pancreatic Cancer Cells Drive Tumor-Associated Macrophage Differentiation via the Siglec Receptors Siglec-7 and Siglec-9

Researchers showed that PDAC tumor cells present an increased sialylation that could be recognized by Siglec-7 and Siglec-9 on myeloid cells.
[Nature Communications]
Rodriguez, E., Boelaars, K., Brown, K., Eveline Li, R. J., Kruijssen, L., Bruijns, S. C. M., van Ee, T., Schetters, S. T. T., Crommentuijn, M. H. W., van der Horst, J. C., van Grieken, N. C. T., van Vliet, S. J., Kazemier, G., Giovannetti, E., Garcia-Vallejo, J. J., & van Kooyk, Y. (2021). Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. Nature Communications, 12(1), 1270. https://doi.org/10.1038/s41467-021-21550-4 Cite
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Glucagon Blockade Restores Functional β-Cell Mass in Type 1 Diabetic Mice and Enhances Function of Human Islets

The authors evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor to maintain glucose homeostasis in type 1 diabetic rodents.
[Proceedings of the National Academy of Sciences of the United States of America]
Wang, M.-Y., Dean, E. D., Quittner-Strom, E., Zhu, Y., Chowdhury, K. H., Zhang, Z., Zhao, S., Li, N., Ye, R., Lee, Y., Zhang, Y., Chen, S., Yu, X., Leonard, D. C., Poffenberger, G., Deylen, A. V., McCorkle, S. K., Schlegel, A., Sloop, K. W., … Holland, W. L. (2021). Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets. Proceedings of the National Academy of Sciences, 118(9). https://doi.org/10.1073/pnas.2022142118 Cite
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Immune Stimulating Antibody‐Photosensitizer Conjugates via Fc‐Mediated Dendritic Cell Phagocytosis and Phototriggered Immunogenic Cell Death for KRAS‐Mutated Pancreatic Cancer Treatment

Cetuximab‐conjugated maleimide‐polyethylene glycol‐chlorin e6 (CMPC) was designed to strengthen its antitumor efficacy. With strong affinity for epidermal growth factor receptor overexpressing Aspc‐1 cells, CMPC with laser exerted the greatest cytotoxicity and induction of immunogenic cell death.
[Small]
Immune Stimulating Antibody‐Photosensitizer Conjugates via Fc‐Mediated Dendritic Cell Phagocytosis and Phototriggered Immunogenic Cell Death for KRAS‐Mutated Pancreatic Cancer Treatment - Kim - - Small - Wiley Online Library. (n.d.). Retrieved February 23, 2021, from https://onlinelibrary.wiley.com/doi/10.1002/smll.202006650 Cite
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A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells

Scientists investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.
[Nutrition and Cancer]
Terasaki, M., Takahashi, S., Nishimura, R., Kubota, A., Kojima, H., Ohta, T., Hamada, J., Kuramitsu, Y., Maeda, H., Miyashita, K., Takahashi, M., & Mutoh, M. (2021). A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. Nutrition and Cancer, 0(0), 1–16. https://doi.org/10.1080/01635581.2020.1863994 Cite
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A Role for PAK1 Mediated Phosphorylation of β-Catenin Ser552 in the Regulation of Insulin Secretion

Researchers found that a Ser552Ala version of β-catenin attenuated glucose stimulated insulin secretion indicating a functional role for Ser552 phosphorylation of β-catenin in insulin secretion.
[Biochemical Journal]
Sorrenson, B., Dissanayake, W. C., Hu, F., Lee, K. L., & Shepherd, P. R. (2021). A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion. Biochemical Journal, BCJ20200862. https://doi.org/10.1042/BCJ20200862 Cite
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UCHL3 Promotes Aerobic Glycolysis of Pancreatic Cancer through Upregulating LDHA Expression

Scientists showed that ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) expression was significantly increased in the pancreatic cancer tissues and cells, and that knocking down UCHL3 noticeably inhibited cell viability and aerobic glycolysis.
[Clinical and Translational Oncology]
Fan, Y., Hu, D., Li, D., Ma, C., Tang, Y., Tao, Q., Deng, L., & Tang, D. (2021). UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression. Clinical and Translational Oncology. https://doi.org/10.1007/s12094-021-02565-1 Cite
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Analysis of the Behavior of 2D Monolayers and 3D Spheroid Human Pancreatic Beta Cells Derived from Induced Pluripotent Stem Cells in a Microfluidic Environment

The authors compared and discussed two strategies for culturing human pancreatic β-cells derived from human induced pluripotent stem cells in microfluidic biochips.
[Journal of Biotechnology]
Essaouiba, A., Jellali, R., Shinohara, M., Scheidecker, B., Legallais, C., Sakai, Y., & Leclerc, E. (2021). Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment. Journal of Biotechnology. https://doi.org/10.1016/j.jbiotec.2021.02.009 Cite
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Nuclear IL-33/SMAD Signaling Axis Promotes Cancer Development in Chronic Inflammation

Interleukin (IL)‐33 was highly expressed in the skin and pancreatic epithelial cells in chronic inflammation, leading to a markedly repressed Smad6 expression as well as dramatically upregulated p‐SMAD2/3 and p‐SMAD1/5 in the epithelial cells.
[EMBO Journal]
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation | The EMBO Journal. (n.d.). Retrieved February 23, 2021, from https://www.embopress.org/doi/abs/10.15252/embj.2020106151 Cite
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JDRF Announces New Center of Excellence in New England to Advance Type 1 Diabetes Research

JDRF announced, in collaboration with the Harvard Stem Cell Institute, the launch of the JDRF Center of Excellence in New England.
[JDRF (PR Newswire, LLC)]
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