MASTL Regulates EGFR Signaling to Impact Pancreatic Cancer Progression

Based on a comprehensive investigation involving pancreatic cancer (PC) patient samples, murine models of PC progression, and loss and gain of function studies, researchers reported a previously undescribed critical role of microtubule-associated serine/threonine-protein kinase-like (MASTL) in promoting cancer malignancy and therapy resistance.
[Oncogene]
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PRMT1-Dependent Regulation of RNA Metabolism and DNA Damage Response Sustains Pancreatic Ductal Adenocarcinoma

Scientists employed an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across a panel of patient-derived pancreatic ductal adenocarcinoma models.
[Nature Communications]
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UBA6 and NDFIP1 Regulate the Degradation of Ferroportin

A HepG2 cell line, which inducibly expresses ferroportin-GFP, was established to test the ability of siRNAs directed against components of the ubiquitin system to prevent BMP6- and exogenous hepcidin-induced ferroportin degradation.
[Haematologica]
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Type 1 Diabetes Glycemic Management: Insulin Therapy, Glucose Monitoring, and Automation

Promising pharmacological advances in insulin therapy include the refinement of extremely rapid insulin analogs, alternate insulin-delivery routes, liver-selective insulins, add-on drugs that enhance insulin effect, and glucose-responsive insulin molecules.
[Science]
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Human Chromosome 3p21.3 Carries TERT Transcriptional Regulators in Pancreatic Cancer

Researchers introduced an intact human chromosome 3 into the human PK9 and murine LTPA pancreatic cancer cell lines using microcell-mediated chromosome transfer.
[Scientific Reports]
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Blood Vessel Organoids Research from Penninger Lab to Play Central Role in 100 Years of Insulin UK-Canada Team Grant Research

LSI Director Dr. Josef Penninger and Drs. David Long, Luigi Gnudi, and Karen Price in the UK are recipients of a UK-Canada Diabetes Research Team Grant entitled “Bridging the gap to translation by understanding and preventing diabetic vascular complications using human organoid culture” as part of the 100 Years of Insulin initiative.
[The University of British Columbia]
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NEK2 Inhibition Triggers Anti-pancreatic Cancer Immunity by Targeting PD-L1

Researchers identified never in mitosis gene A-related kinase 2 (NEK2) as a prognostic factor in immunologically “hot” pancreatic cancer, involved in the onset and development of pancreatic tumors in an immune-dependent manner.
[Nature Communications]
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Metformin Inhibits MAPK Signaling and Rescues Pancreatic Aquaporin 7 Expression to Induce Insulin Secretion in Type 2 Diabetes Mellitus

Researchers investigated the effects of different doses of metformin on AQP7 expression and explored the possible mechanism of its protective effects in the pancreatic islets.
[Journal of Biological Chemistry]
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TRIM15 Promotes the Invasion and Metastasis of Pancreatic Cancer Cells by Mediating APOA1 Ubiquitination and Degradation

Scientists demonstrated that tripartite motif (TRIM) expression was elevated in pancreatic ductal adenocarcinomas tissues, and this elevated expression was associated with a poor prognosis.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
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ANGPTL4 Accelerates KRASG12D-Induced Acinar to Ductal Metaplasia and Pancreatic Carcinogenesis

Scientists investigated the role of ANGPTL4 in KRASG12D-induced acinar-to-ductal metaplasia, pancreatic intraepithelial neoplasia formation, and pancreatic ductal adenocarcinoma maintenance.
[Cancer Letters]
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miRNA-7515 Suppresses Pancreatic Cancer Cell Proliferation, Migration and Invasion via Downregulating IGF-1 Expression

Scientists determined the effects of miR‑7515 on pancreatic cancer cell proliferation, invasion and migration in vitro and in vivo, and investigated its underlying molecular mechanism using bioinformatics, double luciferase assay and western blotting.
[Oncology Reports]
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