Metabolic Programming of Distinct Cancer Stem Cells Promotes Metastasis of Pancreatic Ductal Adenocarcinoma

Scientists investigated the role of distinct subtypes of pancreatic cancer stem cells and their metabolomic signatures in organ-specific metastatic colonization.
[Oncogene]
Nimmakayala, R. K., Leon, F., Rachagani, S., Rauth, S., Nallasamy, P., Marimuthu, S., Shailendra, G. K., Chhonker, Y. S., Chugh, S., Chirravuri, R., Gupta, R., Mallya, K., Prajapati, D. R., Lele, S. M., C. Caffrey, T., L. Grem, J., Grandgenett, P. M., Hollingsworth, M. A., Murry, D. J., … Ponnusamy, M. P. (2020). Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01518-2 Cite
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The KRAS/Lin28B Axis Maintains Stemness of Pancreatic Cancer Cells via the Let-7i/TET3 Pathway

Investigators observed that Lin28B was up‐regulated in pancreatic cancer, contributing to cellular migration and proliferation. Nuclear Lin28B upregulated TET3 mRNA and protein levels by blocking the production of mature let‐7i.
[Molecular Oncology]
Liu, Y., Wang, D., Zhou, M., Chen, H., Wang, H., Min, J., Chen, J., Wu, S., Ni, X., Zhang, Y., Gong, A., & Xu, M. (n.d.). The KRAS/Lin28B axis maintains stemness of pancreatic cancer cells via the let-7i/TET3 pathway. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.12836 Cite
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Galectin-3 Expression in Pancreatic Cell Lines under Distinct Autophagy-Inducing Stimulus

Researchers analyzed the most effective autophagic-inducing conditions in PDAC cells and the effect exerted under these conditions in association with hypoxia on the galectin-3 expression.
[Microscopy and Microanalysis]
Filho, A. F. da S., Sousa, L. M. de, Consonni, S. R., Pitta, M. G. da R., Carvalho, H. F., & Rêgo, M. J. B. de M. (undefined/ed). Galectin-3 Expression in Pancreatic Cell Lines Under Distinct Autophagy-Inducing Stimulus. Microscopy and Microanalysis, 1–11. https://doi.org/10.1017/S1431927620024526 Cite
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miR-375 Induces Adipogenesis through Targeting Erk1 in Pancreatic Duct Cells under the Influence of Sodium Palmitate

The authors researched long‐term saturated fatty acid overexposure that can induce differentiation of pancreatic duct cells into adipocytes and also into β‐cells.
[Journal of Cellular Physiology]
Gezginci‐Oktayoglu, S., Sancar, S., Karatug‐Kacar, A., & Bolkent, S. (n.d.). miR-375 induces adipogenesis through targeting Erk1 in pancreatic duct cells under the influence of sodium palmitate. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30129 Cite
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Molecular Drivers and Cells of Origin in Pancreatic Ductal Adenocarcinoma and Pancreatic Neuroendocrine Carcinoma

Scientists summarize published studies pointing to common potential cells of origin and speculate about how the distinct paths of differentiation are determined by the genomic patterns of each disease.
[Experimental Hematology]
Gao, H.-L., Wang, W.-Q., Yu, X.-J., & Liu, L. (2020). Molecular drivers and cells of origin in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine carcinoma. Experimental Hematology & Oncology, 9(1), 28. https://doi.org/10.1186/s40164-020-00184-0 Cite
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Harnessing the Power and Potential of Regenerative Medicine in Canada

The Stem Cell Network announced today $4.3 million in funding to support stem cell and regenerative medicine research projects that will help to deliver improved health for Canadians and will contribute to national economic recovery. Funded projects include stem cell-based research into new therapeutics for type-1 diabetes, cancer, cystic fibrosis, brain and heart conditions.
[Stem Cell Network]
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Targeted CRISPR Screening Identifies PRMT5 as Synthetic Lethality Combinatorial Target with Gemcitabine in Pancreatic Cancer Cells

Researchers performed an in vivo CRISPR screen in an orthotopic patient-derived xenograft model to identify gene targets whose inhibition created synergistic tumor growth inhibition with gemcitabine, a first- or second-line chemotherapeutic agent for pancreatic ductal adenocarcinoma treatment.
[Proceedings of the National Academy of Sciences of the United States of America]
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Mesoscopic 3D Imaging of Pancreatic Cancer and Langerhans Islets Based on Tissue Autofluorescence

The authors demonstrated a method that without prior immunohistochemical labelling provides insight into the 3D microenvironment and spread of PDAC and premalignant cysts in intact surgical biopsies.
[Scientific Reports]
Hahn, M., Nord, C., Franklin, O., Alanentalo, T., Mettävainio, M. I., Morini, F., Eriksson, M., Korsgren, O., Sund, M., & Ahlgren, U. (2020). Mesoscopic 3D imaging of pancreatic cancer and Langerhans islets based on tissue autofluorescence. Scientific Reports, 10(1), 18246. https://doi.org/10.1038/s41598-020-74616-6 Cite
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Inhibition of NLRP3 Inflammasome by McC950 Improves the Metabolic Outcome of Islet Transplantation by Suppressing IL-1β and Islet Cellular Death

NLRP3 inflammasome-related gene (Nlrp3 and Il1b) expression was upregulated in islets stimulated with proinflammatory cytokines and suppressed when incubated with MCC950.
[Scientific Reports]
Matsuoka, T., Yoshimatsu, G., Sakata, N., Kawakami, R., Tanaka, T., Yamada, T., Yoshida, Y., Hasegawa, S., & Kodama, S. (2020). Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death. Scientific Reports, 10(1), 17920. https://doi.org/10.1038/s41598-020-74786-3 Cite
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Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells

Scientists observed more CD9+C-PEPTIDE+ β cells in the fetal than in the adult cadaveric islets and more Ki67+ proliferating cells among CD9+ fetal β cells. Their experiments showed CD9 as a cell-surface marker for negative enrichment of glucose-responsive β-like cells differentiated from human PSCs.
[Stem Cell Reports]
Li, X., Yang, K. Y., Chan, V. W., Leung, K. T., Zhang, X.-B., Wong, A. S., Chong, C. C. N., Wang, C. C., Ku, M., & Lui, K. O. (2020). Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.09.009 Cite
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The Efficiency of Insulin Production and Its Content in Insulin-Expressing Model β-Cells Correlate with Their Zn2+ Levels

Scientists systematically compared zinc and insulin contents in the permanent INS-1E and BRIN-BD11 β-cells and in the native rat pancreatic islets by flow cytometry, confocal microscopy, immunoblotting, specific messenger RNA and total insulin analysis.
[Open Biology]
Dzianová, P., Asai, S., Chrudinová, M., Kosinová, L., Potalitsyn, P., Šácha, P., Hadravová, R., Selicharová, I., Kříž, J., Turkenburg, J. P., Brzozowski, A. M., Jiráček, J., & Žáková, L. (n.d.). The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels. Open Biology, 10(10), 200137. https://doi.org/10.1098/rsob.200137 Cite
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