Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

The β1-Adrenergic Receptor Links Sympathetic Nerves to T Cell Exhaustion

[Nature] The authors showed a new link between the stress-associated catecholamines and the progression of T cell exhaustion through the β1-adrenergic receptor ADRB1.

Self-Adaptive Nanoregulator to Mitigate Dynamic Immune Evasion of Pancreatic Cancer

[Advanced Materials] Investigators engineered a novel peptide-drug conjugate-based self-adaptive nanoregulator for mitigating dynamic immune evasion of PDAC.

A Microprotein N1DARP Encoded by LINC00261 Promotes Notch1 Intracellular Domain (N1ICD) Degradation via Disrupting USP10-N1ICD Interaction to Inhibit Chemoresistance in Notch1-Hyperactivated Pancreatic Cancer

[Cell Discovery] Researchers identified a previously uncharacterized microprotein, Notch1 degradation-associated regulatory polypeptide (N1DARP), encoded by LINC00261. N1DARP knockout accelerated tumor progression and enhanced stem cell properties in pancreatic cancer organoids and LSL-Kras, LSL-Trp53, and Pdx1-Cre mice.

Noncanonical CDK4 Signaling Rescues Diabetes in a Mouse Model by Promoting β Cell Differentiation

[Journal Of Clinical Investigation] The authors tested whether replacement of endogenous CDK4 with the inhibitor-resistant mutant CDK4-R24C rescued the loss of β cell mass in IRS2-deficient mice.

KMT2A Associates with PHF5A-PHF14-HMG20A-RAI1 Subcomplex in Pancreatic Cancer Stem Cells and Epigenetically Regulates Their Characteristics

[Nature Communications] Targeting the protein subcomplex in pancreatic cancer stem cells with a KMT2A-WDR5 inhibitor attenuated their self-renewal capacity, cell viability, and in vivo tumorigenicity.

Enhanced Antitumor Immunity following Neoadjuvant Chemoradiotherapy Mediates a Favourable Prognosis in Women with Resected Pancreatic Cancer

[Gut] Scientists investigated sex disparities in clinical outcomes and tumor immune profiles in patients with PDAC who underwent upfront resection or resection preceded by gemcitabine-based neoadjuvant chemoradiotherapy.

Biological Characteristics of Pancreatic Ductal Adenocarcinoma: Initiation to Malignancy, Intracellular to Extracellular

[Cancer Letters] The authors elucidate the alterations in intracellular molecules and the extracellular environment that occur during the progression of PDAC.

Quantifying Beta Cell Function in the Preclinical Stages of Type 1 Diabetes

[Diabetologia] Scientists describe the metabolic changes that occur in the early pre-symptomatic stages of type 1 diabetes with respect to both insulin secretion and insulin sensitivity, as well as the measurable outcomes that can be derived from the available tests.

Mounjaro Approved by NICE For Treating Type 2 Diabetes

[Diabetes UK] The National Institute for Health and Care Excellence (NICE) have published draft guidance approving the use of tirzepatide (brand name Mounjaro) for treating type 2 diabetes in England and Wales.

TFEB and TFE3 Control Glucose Homeostasis by Regulating Insulin Gene Expression

[EMBO Journal] Scientists found that nutrient deprivation in beta cells promoted TFEB/TFE3 activation, which resulted in suppression of insulin gene expression. TFEB overexpression was sufficient to inhibit insulin transcription, whereas beta cells depleted of both TFEB and TFE3 failed to suppress insulin gene expression in response to amino acid deprivation.

DNA-Methylation Signature Accurately Differentiates Pancreatic Cancer from Chronic Pancreatitis in Tissue and Plasma

[Gut] Genome-wide variations of DNA-methylation, messenger RNA and microRNA level as well as combinations thereof were analyzed in 345 tissue samples for marker identification. To improve diagnostic performance, researchers established a random-forest machine-learning approach.

Hydroxychloroquine in Stage 1 Type 1 Diabetes

[Diabetes Care] To test whether blocking innate immaune cells modulated progression of the disease, we randomly assigned 273 individuals with stage 1 T1D to treatment with hydroxychloroquine or placebo and assessed whether hydroxychloroquine treatment delayed or prevented progression to stage 2 T1D

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

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