Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Lycopene Ameliorates Islet Function and Down-Regulates the TLR4/MyD88/NF-κB Pathway in Diabetic Mice and Min6 Cells

[Food & Function] By using anti-diabetic metformin as a positive control, investigators demonstrated that lycopene treatment suppressed islet inflammation and apoptosis in both high-fat diet /streptozotocin-induced diabetic mice and in Min6 cells exposed to high glucose/palmitic acid-RAW264.7 conditioned medium.

Membrane Protease Prostasin Promotes Insulin Secretion by Regulating the Epidermal Growth Factor Receptor Pathway

[Scientific Reports] Researchers studied whether epidermal growth factor receptor (EGFR) was a substrate of prostasin (PRSS8) in pancreatic β-cells and that PRSS8 modulated insulin secretion via EGF–EGFR signaling.

Protocol Development To Further Differentiate and Transition Stem Cell-Derived Pancreatic Progenitors From a Monolayer Into Endocrine Cells in Suspension Culture

[Scientific Reports] Scientists developed a protocol to harvest and aggregate human pluripotent stem cells-derived pancreatic progenitors generated using a commercially available kit into near uniform spheroids and to further differentiate the cells toward an endocrine cell fate in suspension culture.

Adipocytes Promote Pancreatic Cancer Migration and Invasion Through Fatty Acid Metabolic Reprogramming

[Oncology Reports] Using an in vitro coculture model, it was shown that adipocytes promoted tumor progression, and an intricate metabolic network between pancreatic cancer cells and adipocytes was identified and elucidated.

POLQ Inhibition Elicits an Immune Response in Homologous Recombination–Deficient Pancreatic Adenocarcinoma via cGAS/STING Signaling

[Journal Of Clinical Investigation] Using human and murine homologous recombination (HR)-deficient PDAC models, scientists found that polymerase theta knockdown was synthetically lethal in combination with mutations in HR genes such as BRCA1 and BRCA2 and the DNA damage repair gene

p53 Inhibitor iASPP Is an Unexpected Suppressor of KRAS and Inflammation-Driven Pancreatic Cancer

[Cell Death & Differentiation] Researchers reported iASPP, an inhibitor of p53, as a paradoxical suppressor of inflammation and oncogenic KRASG12D-driven pancreatic cancer tumorigenesis.

Phosphoproteomics Guides Effective Low-Dose Drug Combinations Against Pancreatic Ductal Adenocarcinoma

[Cell Reports] Using two-step sequential phosphopeptide enrichment, scientists generated a comprehensive phosphoproteome and proteome of nine PDAC cell lines, encompassing more than 20,000 phosphosites on 5,763 phospho-proteins, including 316 protein kinases.

Targeting Pancreatic Cancer With Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation

[Journal Of Medicinal Chemistry] Investigators synthesized a series of plumbagin derivatives and found that 2-(cyclohexylmethyl)-plumbagin inhibited the PI3K/Akt/mTOR signaling pathways, leading to cancer cell death under nutrient-deprived conditions.

An Increased Demand of FAD Synthesis in Differentiated and Stem Pancreatic Cancer Cells Is Accomplished by Modulating FLAD1 Gene Expression

[FEBS Journal] The FAD synthesis process was evaluated in two PDAC cell lines: PANC-1 and PANC-1 derived cancer stem cells (CSCs), presenting the R273H mutation in the oncosuppressor p53, as well as MiaPaca2 and MiaPaca2 derived CSCs, presenting the R248W mutation in p53.

Pancreatic β-Cell Heterogeneity in Adult Human Islets and Stem Cell-Derived Islets

[Cellular And Molecular Life Sciences] The authors summarize the heterogeneity in islet cells of the adult pancreas and those generated from stem cells. They also highlight the significance of this heterogeneity in health and disease conditions and how this can be used to design a stem cell-derived product for diabetes cell therapy.

Dysfunctions, Molecular Mechanisms, and Therapeutic Strategies of Pancreatic β-Cells in Diabetes

[Apoptosis] Investigators summarize current knowledge on the crucial pathways implicated in pancreatic beta cell death. They also focus on applying natural compounds as potential treatment strategies in inhibiting these cell death pathways.

Amphera Announces a Positive Opinion of the European Medicines Agency on the Granting of Orphan Medicinal Product Designation for MesoPher in Pancreatic Cancer

[ZyVersa Therapeutics, Inc.] ZyVersa Therapeutics, Inc. announced that the European Patent Office has issued a “Notice of Intention to Grant” ZyVersa’s patent application covering the company’s Phase IIa-ready Cholesterol Efflux Mediator VAR 200 for use in diabetic nephropathy/diabetic kidney disease.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.