Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Microfluidic Organoid Cultures Derived from Pancreatic Cancer Biopsies for Personalized Testing of Chemotherapy and Immunotherapy

[Advanced Science] Researchers demonstrated that microfluidic patient-derived cancer organoids were phenotypically and genotypically similar to the gold-standard Matrigel organoids with the advantages of 1) spheroid uniformity, 2) minimal cell number requirement, and 3) not relying on Matrigel.

Analysis of BRCA1- and BRCA2-Related Pancreatic Cancer and Survival

[Jama Network Open] This study included 234 consecutively identified patients with germline BRCA PVs and a diagnosis of PDAC. Of patients with BRCA1, 33 of 69 were males with a median age of 63 years. Of patients with BRCA2, 84 of 165 were males, and the median age was 64 years.

Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells

[Diabetes] Investigators discuss conflicting views of the relationship between pancreatic α-cells and β-cells and seek to understand how communication depends on blood flow and/or paracrine mechanisms.

C1QA and COMP: Plasma-Based Biomarkers for Early Diagnosis of Pancreatic Neuroendocrine Tumors

[Scientific Reports] The authors utilized proteomics as a valuable approach for cancer biomarker discovery; therefore, mass spectrometry-based proteomic profiling was conducted on plasma samples from 12 subjects to identify potential proteins capable of effectively distinguishing PanNET from healthy controls.

Inhibiting NR5A2 Targets Stemness in Pancreatic Cancer by Disrupting SOX2/MYC Signaling and Restoring Chemosensitivity

[Journal of Experimental & Clinical Cancer Research] The authors elucidated the function of the nuclear receptor subfamily 5, group A, member 2 (NR5A2) in the context of pancreatic CSCs.

Goat Milk Improves Glucose Metabolism in Type 2 Diabetic Mice and Protects Pancreatic β-Cell Functions

[Molecular Nutrition & Food Research] Type 2 diabetes mice are fed with a goat-milk-based diet containing 10.3% w/w goat milk powder for ten weeks for investigating the in vivo effects; a β cell line MIN6 cells are used to test the in vitro effects of digested goat milk.

Nanoparticles in Pancreatic Cancer Therapy: A Detailed and Elaborated Review on Patent Literature

[Expert Opinion On Therapeutic Patents] Investigators cover all the major nanotechnology-based patent litrature available on renowned patent data bases like Patentscope and Espacenet, through the time period of 2007-2022.

Call for Type 1 Diabetes Screening Gains Momentum

[University of Colorado] The approval of approval of Tzield (teplizumab) in November of 2022, the first-ever disease-modifying drug for T1D, boosted screening momentum. The BDC led clinical trials on the drug, which offers the first tangible reason for testing for the disease that halts glucose-regulating insulin production. In April, Simmons and her University of Colorado School Medicine colleagues became the first in the state to treat a clinical patient with the novel drug on the CU Anschutz Medical Campus.

Extensive Elimination of Acinar Cells During Normal Postnatal Pancreas Growth

[Cell Reports] Investigators demonstrated that early postnatal growth of the pancreas unexpectedly involves massive acinar cell elimination.

High CTCF Expression Mediated by FGD5-AS1/miR-19a-3p Axis Is Associated with Immunosuppression and Pancreatic Cancer Progression

[Heliyon] Researchers examined the CCCTC-binding factor (CTCF) function in pancreatic cancer (PC) and discovered that CTCF expression in PC tissues was significantly raised compared to neighboring healthy tissues.

Suppression of the KRAS-NRF2 Axis Shifts Arginine into the Phosphocreatine Energy System in Pancreatic Cancer Cells

[iScience] Unbiased transcriptome and metabolome analyses showed that PDAC cells with disrupted KRASG12D-NRF2 signalling (NRF2−/− cells) shift from aerobic glycolysis to metabolic pathways fed by amino acids.

Knockdown of TACC3 Inhibits Tumor Cell Proliferation and Increases Chemosensitivity in Pancreatic Cancer

[Cell Death & Disease] The authors found that high TACC3 expression in PDAC is associated with poor prognosis. shRNA-mediated TACC3 knockdown caused S phase arrest of the cell cycle and inhibited proliferation in PDAC cell lines.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.