Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

ACLS4 Could Be a Potential Therapeutic Target for Severe Acute Pancreatitis

[Scientific Reports] The authors conducted a comprehensive transcriptomic analysis of peripheral blood from patients with acute pancreatitis (AP) and the pancreatic tissue from a mouse model of AP. In mouse models of severe AP, ACSL4 was significantly upregulated in the pancreas, whereas GALNT3, WSB1, and IL1R1 were not.

Phase-Changing Citrate Macromolecule Combats Oxidative Pancreatic Islet Damage, Enables Islet Engraftment and Function in the Omentum

[Science Advances] Scientists described at hermoresponsive, antioxidant macromolecule poly(polyethylene glycol citrate-co-N-isopropylacrylamide) (PPCN) to protect islet redox status and function and to enable extrahepatic omentum islet engraftment. Islets entrapped in PPCN and exposed to oxidative stress remained functional and supported long-term euglycemia, in contrast to islets entrapped in a plasma-thrombin biologic scaffold.

Can-Fite Received IRB Approval for the Treatment of Pancreatic Cancer with Namodenoson in a Phase IIa Study

[Can Fite Biopharma] Can-Fite BioPharma announced that it received an approval from the Institutional Review Board (IRB) of Rabin Medical Center, a leading medical institution in Israel where the study will be conducted. The approved protocol has been submitted now to the Ministry of Health.

Pancreas-Directed AAV8-hSPINK1 Gene Therapy Safely and Effectively Protects against Pancreatitis in Mice

[Gut] Scientists explored the potential of adeno-associated virus type 8 (AAV8)-mediated overexpression of human SPINK1 (hSPINK1) for pancreatitis therapy in mice. The effectiveness of AAV8-hSPINK1 on pancreatitis prevention and treatment was studied in three mouse models.

IDH1 Inhibition Potentiates Chemotherapy Efficacy in Pancreatic Cancer

[Cancer Research] Pharmacologic inhibition of wild-type IDH1 with ivosidenib synergized with conventional chemotherapeutics in vitro and potentiated the efficacy of sub-therapeutic doses of these drugs in vivo in murine PDAC models.

Gene Therapy Targeting Key Beta Cell Regulators as a Potential Intervention for Diabetes

[EMBO Molecular Medicine] The authors summarize the roles of pancreatic and duodenal homeobox 1, v-Maf musculoaponeurotic fibrosarcoma oncogene family protein A, and paired box 6 in determining beta cell function and diabetes development. They also explore the potential of gene therapy that delivers these beta cell regulators as therapeutic interventions to rescue beta cell function in diabetes.

Capillary Contact Points Determine Beta Cell Polarity, Control Secretion and are Disrupted in the db/db Mouse Model of Diabetes

[Diabetologia] Using pancreatic slices in mice and humans, investigators set out to determine the proportion of beta cells with multiple contacts and the impact of this on cell structure and function.

Pancreatic Epithelial IL-17/IL-17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis

[Cancer Immunology Research] Deletion of IL-17RA from the pancreatic epithelial compartment, but not from hematopoietic, resulted in delayed premalignant lesions initiation and progression and increased CD8+ cytotoxic T cells infiltration to the tumor microenvironment, investigators reported.

DYRK1B Blockade Promotes Tumoricidal Macrophage Activity in Pancreatic Cancer

[Gut] Scientists used transplantation and autochthonous mouse models of PDAC with either genetic tyrosine phosphorylation-regulated kinase 1B (Dyrk1b) loss or pharmacological DYRK1B inhibition, respectively, to investigate whether DYRK1B represented a promising anticancer target in PDAC.

Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions

[ACS Nano] The authors reported that treatment with tetrafluorosuccinic acid nanoparticles restored lysosomal acidification, autophagic function, and mitochondrial activity, thereby improving the pancreatic function in INS-1 cells and high-fat-diet mice with lipid overload.

Leveraging Zebrafish to Investigate Pancreatic Development, Regeneration, and Diabetes

[Trends In Molecular Medicine] Investigators review recent findings on zebrafish pancreas development, β-cell regeneration, and how zebrafish can be used to provide novel insights into gene functions, disease mechanisms, and therapeutic targets in diabetes, inspiring further use of zebrafish for the development of novel therapies for diabetes.

Genialis and Pancreatic Cancer Action Network (PanCAN) Partner to Progress KRAS Diagnostics

[Genialis] Genialis announced a new partnership with the Pancreatic Cancer Action Network to expand the validation of the Genialis krasID biomarker in the pancreatic cancer histology. Genialis krasID is a new Artificial Intelligence classifier that accurately predicts response and clinical benefit to KRAS inhibitors across preclinical, clinical, and real-world settings.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

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