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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Lannett Company, Lanexa Biologics and Sunshine Lake Pharma announce FDA Approval of LANGLARA™ an Interchangeable Biosimilar of Lantus® (insulin glargine)
[Lannett Company, Inc. (Business Wire)] Lannett Company, Inc., Lanexa Biologics, and Sunshine Lake Pharma announced that the US FDA has approved LANGLARA™ (insulin glargine-aldy), as a biosimilar to Lantus® (insulin glargine), for the treatment of adults and pediatric patients with type 1 diabetes mellitus and adults with type 2 diabetes mellitus.
Sonire Therapeutics Initiates First US Clinical Study of Ultrasound-Guided HIFU Therapy for Pancreatic Cancer
[ Sonire Therapeutics] Sonire Therapeutics announced the initiation of its first US clinical trial, SUNRISE-II, evaluating its proprietary High-Intensity Focused Ultrasound (HIFU) therapy system for the treatment of pancreatic cancer.
GLP-1R-GIPR-PPARα/γ/δ Quintuple Agonism Corrects Obesity and Diabetes in Mice
[Nature] Scientists reported the design and preclinical evaluation of a unimolecular quintuple agonist, which via covalent binding of Lani to a GLP-1R–GIPR co-agonist allows for its targeted delivery into cells that express the receptor for GLP-1 or GIP.
Epigenetic Adaptation of Beta Cells across Lifespan and Disease
[Nature Metabolism] Researchers showed the mapping of genome-wide DNA methylation patterns and the epigenomic basis of beta cell adaptations by leveraging cell-type-specific methylome data from the Human Pancreas Analysis Program.
Cell-Specific DNA Methylation in Human Alpha and Beta Cells Regulates Gene Expression in Type 2 Diabetes
[Nature Metabolism] Scientists showed changes to alpha and beta cell-specific methylomes and transcriptomes from people with or without type 2 diabetes, using whole-genome bisulfite sequencing and RNA sequencing.
Cancer-Associated Fibroblasts Regulate DNA Repair in Pancreatic Cancer through NDRG1-Mediated R-Loop Processing
[Nature Cell Biology] Researchers showed an unexpected link between cancer-associated fibroblast-secreted extracellular matrix (ECM) proteins and enhanced DNA repair. They identified N-myc downstream-regulated gene 1 (NDRG1) as a key mediator that senses signals from the ECM via adhesion receptors and serum and glucocorticoid-activated kinase.
The Circadian Gene Dec2 Promotes Pancreatic Cancer Progression and Dormancy through Immune Evasion
[Developmental Cell] Using a mouse model of resectable PDAC, investigators identified an unknown role of the circadian rhythm gene Differentially Expressed in Chondrocytes 2 (Dec2) in regulating tumor progression and dormancy.
KRAS Signaling Inhibition Induces a Targetable Metabolic Dependency on Lipophagy-Dependent Fatty Acid Oxidation in Pancreatic Cancer
[Cancer Research] Researchers explored metabolic vulnerabilities of PDAC by assessing initial metabolic reprogramming upon ERK inhibition using metabolomics, lipidomics, and isotope-tracing experiments.
Mitochondrial Double-Stranded RNA Fuels Pancreatic Cancer Growth via RIG-I/TLR3 Inflammation
[Proceedings of the National Academy of Sciences of the United States of America] Investigators reported that patients with PDAC with reduced levels of the mitochondrial scaffold, Mic60, or inner mitochondrial membrane protein, exhibit increased inflammation, high NFκB activity and production of TNFα.
Fra-2 Controls the Response to the KRAS Inhibitor MRTX-1133 in Pancreatic Ductal Adenocarcinoma
[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified Fos-related antigen-2 (Fra-2), a stress-responsive transcription factor of the AP-1 family, as a key mediator of adaptive resistance to the KRASG12D selective inhibitor MRTX-1133.
Neuroprotective Strategies for Cognitive Decline in Type 2 Diabetes
[Trends In Endocrinology and Metabolism] The authors propose a conceptual shift in type 2 diabetes management in which cognitive preservation becomes an explicit therapeutic objective, integrating metabolic control with targeted brain-protective approaches.
Circulating Extracellular Vesicle Long RNA Profiling Combined with Machine Learning Unveils Novel Diagnostic Signature and Molecular Features in Chronic Pancreatitis
[Gut] Researchers constructed a diagnostic model for chronic pancreatitis (CP) and depicted molecular landscape of CP based on extracellular vesicle long RNA.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
