Scientists identified CEACAM7 as a potential therapeutic target in PDAC and described the development of CEACAM7-targeted CAR T cells with efficacy against PDAC.
[Clinical Cancer Research]
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Raj, D., Nikolaidi, M., Garces, I., Lorizio, D., Castro, N. M., Caiafa, S. G., Moore, K., Brown, N. F., Kocher, H. M., Duan, X., Nelson, B. H., Lemoine, N. R., & Marshall, J. F. (2021). CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-19-2163 Cite
The authors discuss the roles of lncRNAs in type 2 diabetes (T2D) and cardiovascular disease (CVD) conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.
Researchers suggested that microdose lithium conferred a protective effect on islet β-cells via targeting the GSK3β-regulated Nrf2 antioxidant response and thereby ameliorated type 1 diabetes mellitus and its related kidney impairment.
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The authors showed that La-related protein 1 (LARP1) was the most expressed LARP in mouse islets and human β-cells, being two–four-fold more abundant than LARP1B, a member of the family that also interacts with rapamycin complex 1.
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To fast-track translation of therapies and to inform personalised medicine, researchers aimed to develop a whole-tissue ex vivo explant model that maintains viability, 3D multicellular architecture, and microenvironmental cues of human pancreatic tumours.
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Kokkinos, J., Sharbeen, G., Haghighi, K. S., Ignacio, R. M. C., Kopecky, C., Gonzales-Aloy, E., Youkhana, J., Timpson, P., Pereira, B. A., Ritchie, S., Pandzic, E., Boyer, C., Davis, T. P., Butler, L. M., Goldstein, D., McCarroll, J. A., & Phillips, P. A. (2021). Ex vivo culture of intact human patient derived pancreatic tumour tissue. Scientific Reports, 11(1), 1944. https://doi.org/10.1038/s41598-021-81299-0 Cite
Researchers generated induced pluripotent stem cells (iPSCs) from a patient with FOXA2 haploinsufficiency followed by beta-cell differentiation to understand the role of FOXA2 during pancreatic beta-cell development.
[Cell Death & Disease]
Erytech Pharma S.A. announced the first patient enrolled in a Phase I investigator sponsored trial, named rESPECT, of its lead product eryaspase for the first-line treatment of pancreatic cancer.
[Erytech Pharma S.A.]
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The roles and mechanisms of dopamine to affect the chemotherapeutic efficacy for pancreatic cancer were studied. Multi-omics results revealed that there was a tumor-promoting vicious cycle involving murine pancreatic cancer cells and tumor-associated macrophages.
[Cancer Immunology Immunotherapy]
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Liu, Q., Zhang, R., Zhang, X., Liu, J., Wu, H., Li, Y., Cui, M., Li, T., Song, H., Gao, J., Zhang, Y., Yang, S., & Liao, Q. (2021). Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-020-02816-0 Cite
To directly define the roles of insulin and IGF-1 receptors in the maintenance of pluripotency and differentiation of stem cells, scientists knocked out both the receptors in induced pluripotent stem cells.
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Okawa, E. R., Gupta, M. K., Kahraman, S., Goli, P., Sakaguchi, M., Hu, J., Duan, K., Slipp, B., Lennerz, J. K., & Kulkarni, R. N. (2021). Essential roles of insulin and IGF-1 receptors during embryonic lineage development. Molecular Metabolism, 101164. https://doi.org/10.1016/j.molmet.2021.101164 Cite
Scientists showed that shRNA-mediated SIX2 or SIX3 suppression in human pancreatic adult islets impaired insulin secretion.
[Genes & Development]
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Researchers revealed that increased ataxia-telangiectasia group D-associated gene (ATDC) levels protected cancer cells from reactive oxygen species via stabilization of nuclear factor erythroid 2-related factor 2 (NRF2).
[Genes & Development]
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Purohit, V., Wang, L., Yang, H., Li, J., Ney, G. M., Gumkowski, E. R., Vaidya, A. J., Wang, A., Bhardwaj, A., Zhao, E., Dolgalev, I., Zamperone, A., Abel, E. V., Magliano, M. P. D., Crawford, H. C., Diolaiti, D., Papagiannakopoulos, T. Y., Lyssiotis, C. A., & Simeone, D. M. (2021). ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Genes & Development. https://doi.org/10.1101/gad.344184.120 Cite