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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Crosstalk Between FTH1 and PYCR1 Dysregulates Proline Metabolism and Mediates Cell Growth in KRAS-Mutant Pancreatic Cancer Cells
[Experimental & Molecular Medicine] Scientists observed a direct correlation between ferritin, comprising heavy (FTH1) expression and cell viability and clonogenicity in KRAS-mutant PDAC cell lines as well as with in vivo tumor growth through the control of proline metabolism.
Reprograming Immunosuppressive Microenvironment by eIF4G1 Targeting to Eradicate Pancreatic Ductal Adenocarcinoma
[Cell Reports Medicine] Investigators reported that eukaryotic initiation factor (eIF) 4G1, one of the subunits of eIF4F, was overexpressed in cancer cells and cancer-associated fibroblasts, and this correlated with poor prognosis in patients with PDAC.
Birmingham Opens Europe’s First Pancreatic Cancer mRNA Vaccine Trial
[Birmingham Health Partners] Researchers at BHP founding-members University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham have opened a trial to study how mRNA cancer vaccines may be used to prevent recurrence of pancreatic cancer. The Queen Elizabeth Hospital Birmingham is the first hospital in Europe to recruit into such a trial.
Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
[Clinical Cancer Research] Researchers examined 8,743 patients with RNA sequencing from pancreatic cancer. Classical and basal subtypes were identified using PurIST algorithm on RNA-sequencing and two cohorts were analyzed.
CircRREB1 Mediates Metabolic Reprogramming and Stemness Maintenance to Facilitate Pancreatic Ductal Adenocarcinoma Progression
[Cancer Research] Using circRNA sequencing of diverse PDAC samples, the authors identified circRREB1 as an oncogenic circRNA that was significantly upregulated in PDAC and was correlated with an unfavorable patient prognosis.
Sulfation Pathways in the Maintenance of Functional Beta-Cell Mass and Implications for Diabetes
[Essays In Biochemistry] The authors present evidence for the involvement of sulfation pathways in the maintenance of functional pancreatic beta-cell mass and the implications for diabetes, grouped into various classes of sulfated biomolecule.
Can-Fite: Pancreatic Carcinoma Phase IIa Clinical Study with Namodenoson Received Regulatory Authorization from the Israeli Ministry of Health
[Can Fite Biopharma] Can-Fite BioPharma Ltd. announced that it received approval from the Israeli Ministry of Health to conduct Phase IIa clinical trial with orally-administered Namodenoson in the treatment of pancreatic carcinoma.
Identification of STAM-Binding Protein as a Target for the Treatment of Gemcitabine Resistance Pancreatic Cancer in a Nutrient-Poor Microenvironment
[Cell Death & Disease] Scientists analyzed clinical tissue sample databases using bioinformatics tools and observed significantly upregulated expression of the deubiquitinase STAM-binding protein (STAMBP) in pancreatic cancer (PC) tissues. Functional experiments revealed that STAMBP knockdown remarkably increased gemcitabine sensitivity in PC cells.
FGFR2-Fusions Define a Clinically Actionable Molecular Subset of Pancreatic Cancer
[NPJ Precision Oncology] Researchers presented four fibroblast growth factor receptor (FGFR2) fusion-positive metastatic PDAC patients who exhibited durable responses or disease control to FGFR kinase inhibitors. They monitored variant allele fractions of FGFR2 fusions during FGFR inhibitor treatment and observed dynamic changes correlating with clinical responses.
G3BP2 Promotes Tumor Progression and Gemcitabine Resistance in PDAC via Regulating PDIA3-DKC1-hENT in a Stress Granules-Dependent Manner
[Acta Pharmacologica Sinica] Scientists investigated the relationship between Ras GTPase-activating protein-binding proteins 2 (G3BP2), a core component of stress granules, and the malignancy of PDAC as well as its resistance to the chemotherapy drug gemcitabine.
Researcher Awarded $600,000 Grant to Study Therapeutics to Mitigate Obesity-Linked Diabetes
[Georgia State University] Dr. Chong Hyun Shin, a research assistant professor in the Institute for Biomedical Sciences at Georgia State University, has received a three-year, $600,000 federal grant to study small molecules targeting obesity-linked diabetes.
Pancreatic Cancer-Associated Fibroblasts: Where Do We Go from Here?
[Cancer Research] Scientists summarize the views of several experts in the field, focusing on the current understanding of cancer-associated fibroblasts and challenges to address.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
