De Novo Expression of Gastrokines in Pancreatic Precursor Lesions Impede the Development of Pancreatic Cancer

Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC, where they noted marked upregulation of gastrokine proteins.
[Oncogene]
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ER Stress-Induced Cell Death Proceeds Independently of the TRAIL-R2 Signaling Axis in Pancreatic β Cells

Scientists investigated if TRAIL-R2 dependent signaling towards apoptosis can be induced in pancreatic β cells, whose loss by prolonged ER stress was associated with the onset of diabetes.
[Cell Death Discovery]
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Interactions with Stromal Cells Promote a More Oxidized Cancer Cell Redox State in Pancreatic Tumors

Nontransformed cells in tumors can help cancer cells overcome metabolic limitations, particularly in pancreatic cancer, where pancreatic stellate cells (PSCs) promote cancer cell proliferation and tumor growth.
[Science Advances]
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SENP2 Regulates Mitochondrial Function and Insulin Secretion in Pancreatic β Cells

Using a cell culture system of NIT-1, an islet β cell line, scientists found that increased small ubiquitin-like modifier (SUMO) 2/3 conjugation to DRP1 due to SUMO-specific protease 2 (SENP2) deficiency suppressed the phosphorylation of DRP1, which possibly induced mitochondrial dysfunction.
[Experimental and Molecular Medicine]
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XP-524 Is a Dual-BET/EP300 Inhibitor That Represses Oncogenic KRAS and Potentiates Immune Checkpoint Inhibition in Pancreatic Cancer

Researchers demonstrated that the multispecificity BET/EP300 inhibitor XP-524 has pronounced single-agent efficacy in vitro, in vivo, and ex vivo human PDAC slice cultures, functioning in part by attenuating oncogenic KRAS signaling.
[Proceedings of the National Academy of Sciences of the United States of America]
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A MicroRNA Checkpoint for Ca2+ Signaling and Overload in Acute Pancreatitis

Scientists showed that microRNA-26a inhibited pancreatic acinar cell store-operated Ca2+ entry channel expression, Ca2+ overload, and acute pancreatitis.
[Molecular Therapy]
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Antioxidation of a Proteoglycan from Ganoderma lucidum Protects Pancreatic β-Cells against Oxidative Stress-Induced Apoptosis In Vitro and In Vivo

Researchers investigated systematically the roles of a proteoglycan from Ganoderma lucidum in protection and repair of pancreatic β-cells against oxidative stress-induced injury and apoptosis on molecular, cellular and animal basis.
[International Journal of Biological Macromolecules]
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Urocortin3: Local Inducer of Somatostatin Release and Bellwether of Beta Cell Maturity

Scientists review the mechanistic underpinnings of urocortin 3 signaling, its net effect on islet cell hormone output, as well as its value as a marker for beta cell maturation and functional status.
[Peptides]
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Marker Therapeutics Receives FDA Orphan Drug Designation for Its Multi-Antigen Targeted T Cell Therapy for Pancreatic Cancer

Marker Therapeutics, Inc. announced that the US FDA Office of Orphan Products Development has granted Orphan Drug designation to MT-601, a multi-tumor-associated antigen-specific T cell product optimized for the treatment of patients with pancreatic cancer.
[Marker Therapeutics, Inc.]
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The Inhibition of Panc1 Cancer Cells Invasion by hAMSCs Secretome through Suppression of Tyrosine Phosphorylation of SGK223 (at Y411 Site), C-src (at Y416, Y530 Sites), AKT Activity, and JAK1/Stat3 Signaling

Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.
[Medical Oncology]
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PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Scientists assessed the global protein and individual protein tyrosine phosphatases (PTP) profiles in the pancreas from early onset non-obese diabetic mice treated with an anti-CD3 monoclonal antibody and interleukin-1 receptor antagonist.
[Diabetes]
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