A subcutaneous injectable acellular pancreatic extracellular matrix platform for localizing the bioengineered β cells while creating a pancreas‐like immunogenic microenvironment, in which the autoreactive T cells can interface with the β cells, was devised.
Bigfoot Biomedical, Inc. announced that the FDA has granted 510(k) clearance for first-of-its-kind Bigfoot Unity™ Diabetes Management System, which features connected smart pen caps that recommend insulin doses for people using multiple daily injection therapy.
[Bigfoot Biomedical, Inc. (Business Wire, Inc.)]
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To isolate β cell precursors from late stage pancreatic endocrine progenitor (EP) cells derived from iPS cells, researchers have identified CD82, a member of the tetraspanin family. CD82+ cells at the EP stage differentiated into endocrine cells more efficiently than CD82− EP stage cells.
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Researchers assessed the actions of JMV-449 on pancreatic beta-cells alone, and in combination with glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1).
[Biochimica Et Biophysica Acta-General Subjects]
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Comparison of independent and combined effects of the neurotensin receptor agonist, JMV-449, and incretin mimetics on pancreatic islet function, glucose homeostasis and appetite control. (2021). Biochimica et Biophysica Acta (BBA) - General Subjects, 129917. https://doi.org/10.1016/j.bbagen.2021.129917 Cite
Scientists examined the expression of other Family B Gs‐protein coupled receptor in the cell line and assessed cAMP elevation and neuritogenesis after treatment with their cognate peptide ligands.
[Journal of Neuroendocrinology]
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Xu, W., Dahlke, S. P., Emery, A. C., Sung, M., Chepurny, O. G., Holz, G. G., & Eiden, L. E. (n.d.). Cyclic AMP-dependent activation of ERK via GLP-1 receptor signalling requires the neuroendocrine cell-specific guanine nucleotide exchanger NCS-RapGEF2. Journal of Neuroendocrinology, n/a(n/a), e12974. https://doi.org/https://doi.org/10.1111/jne.12974 Cite
Using functional genomics and subsequent in vitro and in vivo validations, investigators found that pancreatic ductal adenocarcinoma cell lines with high NADPH levels were dependent on peroxiredoxin 4 for their growth and survival.
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Jain, P., Dvorkin-Gheva, A., Mollen, E., Malbeteau, L., Xie, M., Jessa, F., Dhavarasa, P., Chung, S., Brown, K. R., Jang, G. H., Vora, P., Notta, F., Moffat, J., Hedley, D., Boutros, P. C., Wouters, B. G., & Koritzinsky, M. (2021). NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4. Science Advances, 7(19), eabf7114. https://doi.org/10.1126/sciadv.abf7114 Cite
Researchers found that BM-MSC-derived exosomes significantly reduced the invasion, migration, and proliferation of pancreatic cancer cells, as well as tumor stemness.
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Investigators showed that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8+ T cell effector and memory responses, induced cancer-specific humoral immune responses, reduced immunosuppressive CD4+ T regulatory cells, and prevented tumor formation in 75% of pancreatic ductal adenocarcinoma mice.
[Stem Cell Reports]
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Ouyang, X., Liu, Y., Zhou, Y., Guo, J., Wei, T.-T., Liu, C., Lee, B., Chen, B., Zhang, A., Casey, K. M., Wang, L., Kooreman, N. G., Habtezion, A., Engleman, E. G., & Wu, J. C. (2021). Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.04.004 Cite
Researchers developed a six-tier grading scheme for neoadjuvant responses evaluating the remaining tumor cells in surgical specimens.
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Eurola, A., Ristimäki, A., Mustonen, H., Nurmi, A.-M., Hagström, J., Haglund, C., & Seppänen, H. (2021). Impact of histological response after neoadjuvant therapy on podocalyxin as a prognostic marker in pancreatic cancer. Scientific Reports, 11(1), 9896. https://doi.org/10.1038/s41598-021-89134-2 Cite
Scientists presented the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells.
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Hébert, A., Parisotto, M., Rowell, M.-C., Doré, A., Fernandez Ruiz, A., Lefrançois, G., Kalegari, P., Ferbeyre, G., & Schmitzer, A. R. (2021). Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth. Scientific Reports, 11(1), 9854. https://doi.org/10.1038/s41598-021-87993-3 Cite
The authors describe the evidence of an association and causal link between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), discusses the putative pathophysiological mechanisms linking NAFLD to T2DM and summarizes the current pharmacological treatments for NAFLD or T2DM that might benefit or adversely affect the risk of T2DM or NAFLD progression.
[Nature Reviews Gastroenterology & Hepatology]