Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

MicroRNA-21 Promotes Pancreatic β Cell Function Through Modulating Glucose Uptake

[Nature Communications] Investigators reported that miR-21 enhanced glucose uptake and subsequently promoted insulin secretion by up-regulating Glut2 expression in a miR-21-Pdcd4-AP-1 dependent pathway.

Very-Low-Density Lipoprotein Receptor-Enhanced Lipid Metabolism in Pancreatic Stellate Cells Promotes Pancreatic Fibrosis

[Immunity] Single-cell RNA sequencing revealed the heterogeneity of pancreatic stellate cell (PSCs) and identified very-low-density lipoprotein receptor+ PSCs that were characterized by a higher lipid metabolism.

ACLP Promotes Activation of Cancer-Associated Fibroblasts and Tumor Metastasis via ACLP-PPARγ-ACLP Feedback Loop in Pancreatic Cancer

[Cancer Letters] The authors reported that aortic carboxypeptidase–like protein (ACLP) was mainly expressed in cancer-associated fibroblasts (CAFs) but not in cancer cells and highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues.

Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer

[Diabetes] Using total internal reflection fluorescence microscopy, scientists monitored insulin granule exocytosis in primary islet cells to dissect the effect of dopamine.

Methionine Oxidation Activates Pyruvate Kinase M2 To Promote Pancreatic Cancer Metastasis

[Molecular Cell] Scientists reported that methionine sulfoxide reductase A (MSRA) expression is decreased in the metastatic tumors of pancreatic ductal adenocarcinoma (PDA) patients, whereas MSRA loss in primary PDA cells promotes migration and invasion.

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

[Cancer Research] The authors reported that in patient-derived organoid models in vitro and patient-derived xenograft models in vivo, mitochondrial calcium uniporter (MCU)-high PDAC demonstrated increased sensitivity to SLC7A11 inhibition compared with MCU-low tumors.

Transcription Factor p8 Regulates Autophagy in Response to Disulfiram via PI3K/mTOR/p70S6K Signaling Pathway in Pancreatic Cancer Cells

[Human Cell] Scientists reported that disulfiram formed potent complexes with copper, inhibited cell proliferation, and induced apoptosis in human pancreatic cancer cells, which was detected by flow cytometry and western blotting.

S100A11 Activates the Pentose Phosphate Pathway To Induce Malignant Biological Behaviour of Pancreatic Ductal Adenocarcinoma

[Cell Death & Disease] Investigators reported that S100A11 expression was increased in PDAC and significantly associated with worse prognosis and disease progression.

Occult Polyclonality of Preclinical Pancreatic Cancer Models Drives In Vitro Evolution

[Nature Communications] Scientists applied single-cell sequencing technologies to reveal inherent heterogeneity in assumptively monoclonal pancreatic cancer cell lines and patient-derived organoids.

Aberrant APOBEC3C Expression Induces Characteristic Genomic Instability in Pancreatic Ductal Adenocarcinoma

[Oncogenesis] Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3C)-overexpressing cell lines were generated to substantiate the effects of APOBEC3C on the PDAC genome, including alterations in single-nucleotide variant classes and the formation of kataegis regions.

β2-Adrenergic Receptor Drives the Metastasis and Invasion of Pancreatic Ductal Adenocarcinoma Through Activating Cdc42 Signaling Pathway

[Journal of Molecular Histology] Scientists reported that β2-adrenergic receptor recruited Cdc42 in response to isoproterenol exposure in PDAC cells.

Methionine Oxidation Activates Pyruvate Kinase M2 to Promote Pancreatic Cancer Metastasis

[Molecular Cell] Chemoproteomic profiling of pancreatic organoids revealed that methionine sulfoxide reductase A loss resulted in the selective oxidation of a methionine residue in pyruvate kinase M2.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.