Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Spatial Mapping of Transcriptomic Plasticity in Metastatic Pancreatic Cancer
[Nature] Researchers constructed high-resolution maps of lineage states, clonal architecture, and the tumor microenvironment using spatially resolved transcriptomics from 55 samples of primary tumor and metastases collected from rapid autopsies of 13 people.
RFX3 Is Essential for the Generation of Functional Human Pancreatic Islets from Stem Cells
[Diabetologia] Scientists generated regulatory factor X 3 (RFX3) knockout iPSC lines using CRISPR/Cas9 and differentiated them into pancreatic islet organoids.
Targeting PIKfyve-Driven Lipid Metabolism in Pancreatic Cancer
[Nature] The authors characterized PIKfyve, a lipid kinase that was integral to lysosomal functioning7, as a targetable vulnerability in PDAC.
Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes
[Nature Communications] Scientists constructed a genome-wide protein quantitative trait loci map of 1985 proteins in 695 newborn babies at increased genetic risk of developing type 1 diabetes.
Macrophages and Fibroblasts As Regulators of the Immune Response in Pancreatic Cancer
[Nature Immunology] Scientists provide an overview of the heterogeneity of cancer-associated fibroblasts and tumor-associated macrophages, how they establish an immunosuppressive microenvironment and their collaboration in the remodeling of the ECM.
Advancing toward a Curative Frontier: An Updated Narrative Review on Stem-Cell Therapy in Pediatric Type 1 Diabetes
[World Journal of Pediatrics] A comprehensive review of the literature was conducted to evaluate stem-cell types: embryonic, perinatal, adult, induced pluripotent and cancer stem cells, and their role in T1D treatment.
Gold Nanoparticle Resveratrol Complex Increases Apoptosis in KRAS Mutant Pancreatic Cancer Cells
[Scientific Reports] To enhance delivery rate and efficacy, the size of about 30 nm gold nanoparticles was synthesized and conjugated to resveratrol via polyvinylpyrrolidone for high bioavailability.
Insulin Resistance in Type 2 Diabetes Mellitus
[Nature Reviews Endocrinology] The authors review established and emerging cellular mechanisms of insulin resistance, their complex integrative features and their relevance to disease progression.
Islet Autoantibodies and Their Association With β-Cell Function and Diabetes Measures in Children With Acute Recurrent and Chronic Pancreatitis
[Diabetes Care] This was a retrospective cross-sectional analysis of 234 youth with acute recurrent pancreatitis/chronic pancreatitis who had islet Ab testing. Fasting glucose and HbA1c were collected.
A Novel Peptide RR-171 Derived from Human Umbilical Cord Serum Induces Apoptosis and Pyroptosis in Pancreatic Cancer Cells
[Scientific Reports] The anti-pancreatic cancer properties of RR-171 were detected by a cell counting kit-8, colony formation, flow cytometry, LDH release, and EdU incorporation assays.
Off-the-Shelf Invariant NKT Cells Expressing Anti-PSCA CAR and IL-15 Promote Pancreatic Cancer Regression in Mice
[Journal of Clinical Investigation] The authors generated cryopreserved, off-the-shelf, allogeneic prostate stem cell antigen chimeric antigen receptor invariant NKT cells using human peripheral blood mononuclear cells as a cell source.
Miro1- A Key Player in β-cell Function and Mitochondrial Dynamics under Diabetes Mellitus
[Mitochondrion] Scientists explore the dysfunction of Miro1 in type 2 diabetes mellitus and its contribution to impaired Ca2+ signaling, which increases oxidative stress in β-cells.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
