Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Xilio Therapeutics Announces Preliminary Clinical Data From Phase I Trial of XTX101, a Tumor-Activated, FC-Enhanced Anti-CTLA-4, in Patients With Advanced Solid Tumors

[Xilio Therapeutics, Inc.] Xilio Therapeutics, Inc. announced preliminary data from its Phase I clinical trial evaluating XTX101, an investigational tumor-activated, Fc-enhanced anti-CTLA-4, in patients with advanced solid tumors.

3-Hydroxybutyrate Ameliorates Insulin Resistance by Inhibiting PPARγ Ser273 Phosphorylation in Type 2 Diabetic Mice

[Signal Transduction And Targeted Therapy] Investigators demonstrated that 3-Hydroxybutyrate reduced fasting blood glucose levels, improved glucose tolerance, and ameliorated insulin resistance in type 2 diabetic mice through hydroxycarboxylic acid receptor 2.

FTZ Promotes Islet β-Cell Regeneration in T1DM Mice via the Regulation of Nuclear Proliferation Factors

[Journal Of Ethnopharmacology] Scientists investigated the role of the Fufang-Zhenzhu-Tiaozhi capsule, a traditional Chinese medicine, in promoting β-cell regeneration in T1DM mice, and to further explore its mechanism.

Elucidation of HHEX in Pancreatic Endoderm Differentiation Using a Human iPSC Differentiation Model

[Scientific Reports] Researchers elucidated the molecular mechanisms underlying pancreatic endoderm differentiation by searching for factors that regulate a crucial pancreatic endoderm marker gene, NKX6.1

Silibinin Alleviates Ferroptosis of Rat Islet β Cell INS-1 Induced by the Treatment With Palmitic Acid and High Glucose Through Enhancing PINK1/Parkin-Mediated Mitophagy

[Archives Of Biochemistry And Biophysics] Scientists conducted an in vitro study investigating the effects of silibinin on palmitic acid and high glucose-induced cell loss and ferroptosis of rat insulinoma INS-1 cells.

Liposomes Targeting the Cancer Cell-Exposed Receptor, Claudin-4, for Pancreatic Cancer Chemotherapy

[Biomaterials Research] Investigators developed a Clostridium perfringens enterotoxin 17-containing liposome that targets pancreatic cancers through binding to exposed claudin-4.

PLEKHG5 Is Stabilized by HDAC2-Related Deacetylation and Confers Sorafenib Resistance in Hepatocellular Carcinoma

[Cell Death Discovery] Scientists found that PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5), a RhoGEF, was highly upregulated in sorafenib-resistant cells. PLEKHG5 overexpression activated Rac1/AKT/NF-κB signaling and reduced sensitivity to sorafenib in HCC cells.

Pulsatilla Decoction and Its Bioactive Component β-Peltatin Induce G2/M Cell Cycle Arrest and Apoptosis in Pancreatic Cancer

[Chinese Medicine] Investigators demonstrated that Pulsatilla Decoction markedly inhibited PAC cell proliferation and triggered their apoptosis.

Effects of LPA Receptor-Mediated Signaling on the Modulation of Cellular Functions of Pancreatic Cancer Cells Cultured in Fibroblast Supernatants Under Hypoxic Conditions

[Journal Of Bioenergetics And Biomembranes] Researchers investigated whether lysophosphatidic acid receptor-mediated signaling regulates cellular functions by the tumor microenvironment of pancreatic cancer PANC-1 cells.

Emerging Role of Pancreatic Stellate Cell-Derived Extracellular Vesicles in Pancreatic Cancer

[Seminars In Cancer Biology] The authors provide an overview of PDAC, pancreatic stellate cells and their interactions with cancer cells, as well as the currently known role of extracellular vesicles derived from pancreatic stellate cells in PDAC progression.

Dissecting the Interrelationship Between COVID-19 and Diabetes Mellitus

[Advanced Biology] Investigators look into the interrelationship between COVID-19 and diabetes mellitus with the aim to provide mechanistic insights into the process by which SARS-CoV-2 infects the pancreas and mediates dysfunction and death of endocrine islets.

Brg1 Controls Stemness and Metastasis of Pancreatic Cancer through Regulating Hypoxia Pathway

[Oncogene] Scientists investigated the importance of Brg1 for established pancreatic ductal adenocarcinoma (PDAC) by using a mouse model with a dual recombinase system.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.