Scientists demonstrated that NR5A2 acted as a negative prognostic biomarker in PDAC. NR5A2 silencing inhibited the proliferation and migration abilities of pancreatic cancer cells in vitro and in vivo.
[Cell Death Discovery]
Guo, F., Zhou, Y., Guo, H., Ren, D., Jin, X., & Wu, H. (2021). NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15. Cell Death Discovery, 7(1), 1–15. https://doi.org/10.1038/s41420-021-00462-8 Cite
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