Category Archives: Pancreatic Cell

Pancreatic Cell News is an online publication and email newsletter providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
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Pancreatic Cell News is a weekly newsletter that highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma

Scientists identified CEACAM7 as a potential therapeutic target in PDAC and described the development of CEACAM7-targeted CAR T cells with efficacy against PDAC.
[Clinical Cancer Research]
Raj, D., Nikolaidi, M., Garces, I., Lorizio, D., Castro, N. M., Caiafa, S. G., Moore, K., Brown, N. F., Kocher, H. M., Duan, X., Nelson, B. H., Lemoine, N. R., & Marshall, J. F. (2021). CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-19-2163 Cite
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Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes

The authors discuss the roles of lncRNAs in type 2 diabetes (T2D) and cardiovascular disease (CVD) conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.
[Diagnostics]
Ismail, N., Abdullah, N., Abdul Murad, N. A., Jamal, R., & Sulaiman, S. A. (2021). Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes. Diagnostics, 11(1), 145. https://doi.org/10.3390/diagnostics11010145 Cite
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Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes

Researchers suggested that microdose lithium conferred a protective effect on islet β-cells via targeting the GSK3β-regulated Nrf2 antioxidant response and thereby ameliorated type 1 diabetes mellitus and its related kidney impairment.
[Antioxidants]
Zhang, J., Anshul, F., Malhotra, D. K., Jaume, J., Dworkin, L. D., & Gong, R. (2021). Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes. Antioxidants, 10(1), 138. https://doi.org/10.3390/antiox10010138 Cite
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The RNA-Binding Protein LARP1 Is Dispensable for Pancreatic β-Cell Function and Mass

The authors showed that La-related protein 1 (LARP1) was the most expressed LARP in mouse islets and human β-cells, being two–four-fold more abundant than LARP1B, a member of the family that also interacts with rapamycin complex 1.
[Scientific Reports]
Werneck-de-Castro, J. P., Peçanha, F. L. M., Silvestre, D. H., & Bernal-Mizrachi, E. (2021). The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass. Scientific Reports, 11(1), 2079. https://doi.org/10.1038/s41598-021-81457-4 Cite
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Ex Vivo Culture of Intact Human Patient Derived Pancreatic Tumor Tissue

To fast-track translation of therapies and to inform personalised medicine, researchers aimed to develop a whole-tissue ex vivo explant model that maintains viability, 3D multicellular architecture, and microenvironmental cues of human pancreatic tumours.
[Scientific Reports]
Kokkinos, J., Sharbeen, G., Haghighi, K. S., Ignacio, R. M. C., Kopecky, C., Gonzales-Aloy, E., Youkhana, J., Timpson, P., Pereira, B. A., Ritchie, S., Pandzic, E., Boyer, C., Davis, T. P., Butler, L. M., Goldstein, D., McCarroll, J. A., & Phillips, P. A. (2021). Ex vivo culture of intact human patient derived pancreatic tumour tissue. Scientific Reports, 11(1), 1944. https://doi.org/10.1038/s41598-021-81299-0 Cite
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Aberrant Development of Pancreatic Beta Cells Derived from Human iPSCs with FOXA2 Deficiency

Researchers generated induced pluripotent stem cells (iPSCs) from a patient with FOXA2 haploinsufficiency followed by beta-cell differentiation to understand the role of FOXA2 during pancreatic beta-cell development.
[Cell Death & Disease]
Elsayed, A. K., Younis, I., Ali, G., Hussain, K., & Abdelalim, E. M. (2021). Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency. Cell Death & Disease, 12(1), 1–17. https://doi.org/10.1038/s41419-021-03390-8 Cite
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ERYTECH Announces First Patient Enrolled in a Phase I Investigator Sponsored Trial of Eryaspase in First-Line Pancreatic Cancer

Erytech Pharma S.A. announced the first patient enrolled in a Phase I investigator sponsored trial, named rESPECT, of its lead product eryaspase for the first-line treatment of pancreatic cancer.
[Erytech Pharma S.A.]
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Dopamine Improves Chemotherapeutic Efficacy for Pancreatic Cancer by Regulating Macrophage-Derived Inflammations

The roles and mechanisms of dopamine to affect the chemotherapeutic efficacy for pancreatic cancer were studied. Multi-omics results revealed that there was a tumor-promoting vicious cycle involving murine pancreatic cancer cells and tumor-associated macrophages.
[Cancer Immunology Immunotherapy]
Liu, Q., Zhang, R., Zhang, X., Liu, J., Wu, H., Li, Y., Cui, M., Li, T., Song, H., Gao, J., Zhang, Y., Yang, S., & Liao, Q. (2021). Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-020-02816-0 Cite
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Essential Roles of Insulin and IGF-1 Receptors during Embryonic Lineage Development

To directly define the roles of insulin and IGF-1 receptors in the maintenance of pluripotency and differentiation of stem cells, scientists knocked out both the receptors in induced pluripotent stem cells.
[Molecular Medicine]
Okawa, E. R., Gupta, M. K., Kahraman, S., Goli, P., Sakaguchi, M., Hu, J., Duan, K., Slipp, B., Lennerz, J. K., & Kulkarni, R. N. (2021). Essential roles of insulin and IGF-1 receptors during embryonic lineage development. Molecular Metabolism, 101164. https://doi.org/10.1016/j.molmet.2021.101164 Cite
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SIX2 and SIX3 Coordinately Regulate Functional Maturity and Fate of Human Pancreatic β Cells

Scientists showed that shRNA-mediated SIX2 or SIX3 suppression in human pancreatic adult islets impaired insulin secretion.
[Genes & Development]
Bevacqua, R. J., Lam, J. Y., Peiris, H., Whitener, R. L., Kim, S., Gu, X., Friedlander, M. S. H., & Kim, S. K. (2021). SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells. Genes & Development. https://doi.org/10.1101/gad.342378.120 Cite
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ATDC Binds to KEAP1 to Drive NRF2-Mediated Tumorigenesis and Chemoresistance in Pancreatic Cancer

Researchers revealed that increased ataxia-telangiectasia group D-associated gene (ATDC) levels protected cancer cells from reactive oxygen species via stabilization of nuclear factor erythroid 2-related factor 2 (NRF2).
[Genes & Development]
Purohit, V., Wang, L., Yang, H., Li, J., Ney, G. M., Gumkowski, E. R., Vaidya, A. J., Wang, A., Bhardwaj, A., Zhao, E., Dolgalev, I., Zamperone, A., Abel, E. V., Magliano, M. P. D., Crawford, H. C., Diolaiti, D., Papagiannakopoulos, T. Y., Lyssiotis, C. A., & Simeone, D. M. (2021). ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Genes & Development. https://doi.org/10.1101/gad.344184.120 Cite
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