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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Neoadjuvant BMS-813160, Nivolumab, Gemcitabine, and Nab-Paclitaxel for Patients with Pancreatic Cancer
[Clinical Cancer Research] Scientists conducted a Phase I/II single institution study combining chemotherapy gemcitabine and nab-paclitaxel, CCR2/5 inhibitor BMS-813160, and nivolumab for four 28-day cycles for patients with borderline resectable or locally advanced PDAC.
Genetic Protection from Type 1 Diabetes Resulting from Accelerated Insulin mRNA Decay
[Cell] Investigators discovered that the inositol-requiring enzyme 1α (IRE1α) digestion motif was present in insulin mRNA carrying SNP rs3842752. This SNP in the 3′ untranslated region of insulin gene associated with protection from T1D.
Septin5 Deletion Enhances β-cell Exocytosis by Releasing Microtubule-Tethered Insulin Granules onto Plasma Membrane
[Nature Communications] Scientists reported that Septin5 was abundant in rodent and human β-cells, deletion of which dramatically enhanced biphasic glucose-stimulated insulin secretion, including in type 2 diabetes.
Investigating Synthetic Lethality and PARP Inhibitor Resistance in Pancreatic Cancer through Enantiomer Differential Activity
[Cell Death Discovery] Through multiple, integrated orthogonal biological approaches in different 2D and 3D PDAC cultures, researchers characterized RS-35d enantiomers, in terms of mode of action and single contributions.
PLXDC1+ Tumor-Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma
[Advanced Science] Researchers combined RNA sequencing and assay for transposase-accessible chromatin using sequencing on sorted pancreatic stellate cells from adjacent normal and PDAC tissues to investigate their transcriptional and epigenetic activation.
NIH Cancels Funding for Landmark Diabetes Study at a Time of Focus on Chronic Disease
[STAT] The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said, at a time when top officials have emphasized their determination to curb the incidence of such chronic conditions.
PEP-Therapy Receives FDA Orphan Drug Designation for PEP-010 for Treatment of Pancreatic Cancer
[PEP-Therapy (GlobeNewswire)] PEP-Therapy announced that the US FDA has granted Orphan Drug designation to its flagship product, PEP-010, for the treatment of pancreatic cancer.
Polysaccharide from Momordica charantia L. Alleviates Type 2 Diabetes Mellitus in Mice by Activating the IRS1/PI3K/Akt and AMPK Signaling Pathways and Regulating the Gut...
[Journal of Agricultural and Food Chemistry] Scientists explored the novel antidiabetic potential of MCPS-3, a polysaccharide derived from Momordica charantia L., and its underlying mechanisms in a high-fat diet and streptozotocin-induced T2DM mouse model.
Liver-Derived Neuregulin1α Stimulates Compensatory Pancreatic β Cell Hyperplasia in Insulin Resistance
[Nature Communications] Researchers showed that a liver-derived secreted protein, Neuregulin1α, promoted compensatory proliferation of pancreatic β cells in type 2 diabetes.
Anocca Announces Authorization of Clinical Trial Application to Start First In-Human Trial in Advanced Pancreatic Cancer
[Anocca AB] Anocca AB announced the authorization of its Clinical Trial Application from the regulatory authorities in four European countries under the European Union’s harmonized framework, for VIDAR-1, a Phase I/II multi-product umbrella trial in patients with mutated KRAS-positive advanced pancreatic cancer.
Endocrine-Exocrine Mir-503-322 Drives Aging-Associated Pancreatitis Via Targeting MKNK1 in Acinar Cells
[Nature Communications] Scientists demonstrate that senescent β-cells of endocrine pancreas decided the onset and severity of chronic and acute pancreatitis.
ADT-1004: A First-in-Class, Oral Pan-RAS Inhibitor with Robust Antitumor Activity in Preclinical Models of Pancreatic Ductal Adenocarcinoma
[Molecular Cancer] Investigators developed a novel pan-RAS inhibitor, ADT-1004 and evaluated antitumor activity in murine and human PDAC models. ADT-1004 had strong antitumor activity in aggressive and clinically relevant PDAC models with unique selectivity to block RAS-mediated signaling in RAS mutant cells.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
