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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
The GLP-1R Agonist Semaglutide Reshapes Pancreatic Cancer Associated Fibroblasts Reducing Collagen Proline Hydroxylation and Favoring T Lymphocyte Infiltration
[Journal of Experimental & Clinical Cancer Research] Scientists investigated the effect of dysmetabolism on pancreatic ductal adenocarcinoma (PDAC) development in a pre-clinical PDAC model with a specific focus on the stromal compartment.
Adjuvant Chemotherapy after Resection of Localized Pancreatic Adenocarcinoma following Preoperative FOLFIRINOX
[Jama Oncology] This retrospective cohort study included patients with localized PDAC treated with 2 to 11 cycles of preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) followed by resection.
SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer
[Cancer Research] Investigators used single-cell RNA-sequencing to analyze the cellular landscape of Trp53-mutant mouse models driven by KrasG12D or KrasG12V in which Smad4 was wild-type or deleted.
Lineage Tracing of Pancreatic Cells for Mechanistic and Therapeutic Insights
[Trends In Endocrinology and Metabolism] Scientists summarize advances, challenges, and future directions in tracing pancreatic cell origins and fates using lineage-tracing technologies.
Betagenin Ameliorates Diabetes by Inducing Insulin Secretion and β-Cell Proliferation
[Journal of Biological Chemistry] Researchers isolated and identified a new intestine-derived hormone, betagenin, and showed that it stimulated insulin secretion and β-cell proliferation and suppresses β-cell apoptosis.
Targeting uPAR with An Antibody-Drug Conjugate Suppresses Tumor Growth And Reshapes The Immune Landscape In Pancreatic Cancer Models
[Science Advances] The authors explored the urokinase plasminogen activator receptor (uPAR) as a candidate antibody-drug conjugate target in PDAC, harnessing its massive tumoral and stromal expression in this stroma-dense tumor.
BE-43547A2 Exerts Hypoxia-Selective Inhibition on Human Pancreatic Cancer Cells through Targeting eEF1A1 and Disrupting Its Association with FoxO1
[Acta Pharmacologica Sinica] Scientists investigated the molecular mechanism underlying the hypoxia selectivity of BE-43547A2 in human pancreatic cancer cells.
$3.4M Grant Targets Pancreatic Cancer Risk
[Innovent Biologics, Inc. (PR Newswire)] The University of Hawaiʻi Cancer Center has secured a $3.4 million grant from the National Cancer Institute for a new study aimed at improving pancreatic cancer risk prediction and prevention.
Intercellular TIMP-1-CD63 Signaling Directs the Evolution of Immune Escape and Metastasis in KRAS-Mutated Pancreatic Cancer Cells
[Molecular Cancer] Scientists investigated how KRAS-mutated epithelial cells acquired the capacity to escape senescence or even immune clearance, thereby progressing to advanced pancreatic ductal adenocarcinoma.
Neuronal-ILC2 Interactions Regulate Pancreatic Glucagon and Glucose Homeostasis
[Science] Scientists provided evidence that immune cells could be regulated by neuronal signals in response to fasting, activating an inter-organ communication route that promoted pancreatic endocrine function and regulation of blood glucose levels.
Targeting MXD1 Sensitises Pancreatic Cancer to Trametinib
[Gut] Scientists illustrated the mechanisms of resistance to trametinib in PDAC and identified trametinib resistance-associated druggable targets, thus improving the treatment efficacy of trametinib-resistant PDAC.
Melanophilin-Induced Primary Cilia Promote Pancreatic Cancer Metastasis
[Cell Death & Disease] Researchers demonstrated that melanophilin (MLPH) promoted PDAC metastasis by inducing the regrowth of primary cilia. Clinically, high MLPH expression was positively correlated with metastasis and poor PDAC prognosis.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
