Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Pancreatic Stellate Cells and the Interleukin Family: Linking Fibrosis and Immunity to Pancreatic Ductal Adenocarcinoma

[Molecular Medicine Reports] The authors review the roles of pancreatic stellate cells, differentiated cancer‑associated fibroblasts and the interleukin family, either independently or in combination, in the progression of precursor lesions in pancreatic intraepithelial neoplasia and PDAC.

PDX1+ Cell Budding Morphogenesis in a Stem Cell-Derived Islet Spheroid System

[Nature Communications] Investigators devised a tunable strategy to generate islet spheroids enriched for major islet cell types by incorporating PDX1+ cell budding morphogenesis into staged differentiation.

Blockade of IL-1β and PD-1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor

[Cancer Immunology Research] Investigators reported clinical and translational results from a phase Ib trial testing whether IL-1β blockade in human pancreatic cancer would alleviate myeloid immunosuppression and reveal antitumor T-cell responses to PD-1 blockade.

Can-Fite Applies for FDA Orphan Drug Designation for Namodenoson in the Treatment of Pancreatic Cancer

[Can-Fite Biopharma] Can-Fite BioPharma announced that it has submitted an application to the US FDA for Orphan Drug Designation for its drug candidate Namodenoson in the treatment of pancreatic carcinoma.

Intratumoral NKT Cell Accumulation Promotes Antitumor Immunity in Pancreatic Cancer

[Proceedings of The National Academy of Sciences of The United States of America] Using the mouse KRT19-deficient pancreatic ductal adenocarcinoma model (PDA), researchers reported that intratumoral accumulation of natural killer T cells (NKT) was required to establish an immunologically active tumor microenvironment (TME). Administration of folinic acid to mice bearing PDA increased NKT cells in the TME and improved their response to anti-PD-1 antibody treatment.

ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

[Cancer Discovery] Researchers identified the receptor tyrosine kinase Ror2 as marker of a gastric metaplasia-like identity in pancreas neoplasms. Ablation of Ror2 in a mouse model of pancreatic tumorigenesis promoted a switch to a gastric pit cell identity that largely persisted through progression to the classical subtype of PDAC.

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

[Cancer Discovery] In PDAC cell lines and organoid models treated with the KRASG12D inhibitor MRTX1133, epithelial-to-mesenchymal transition and PI3K-AKT-mTOR signaling associated with resistance to therapy.

A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreas Cancer

[Cancer Discovery] Using genetically engineered mouse models and patient-derived xenografts, researchers discovered that basal PDAC cells were highly sensitive to KRAS inhibitors. Employing fluorescent and bioluminescent reporter systems, they longitudinally tracked cell-state dynamics in vivo and revealed a rapid, KRAS inhibitor-induced enrichment of the classical state.

Single-Cell Transcriptomic Profiling of Human Pancreatic Islets Reveals Genes Responsive to Glucose Exposure over 24 H

[Diabetologia] Scientists explored the effects of in vitro hyperglycaemic conditions on human pancreatic islet gene expression across 24h in six pancreatic cell types: alpha, beta, gamma, delta, ductal, and acinar.

Engineered Matrices Reveal Stiffness-Mediated Chemoresistance in Patient-Derived Pancreatic Cancer Organoids

[Nature Materials] Researchers designed and engineered matrices that recapitulated the key hallmarks of the PDAC tumour extracellular matrix. They showed that patient-derived PDAC organoids developed resistance to several clinically relevant chemotherapies when cultured within high-stiffness matrices mechanically matched to in vivo tumors.

Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth

[Cancer Discovery] Using compartment-specific IL-33 knockout mice, scientists observed that lack of stromal IL-33 led to profound reprogramming of multiple components of the pancreatic tumor microenvironment. Notably, an increase in CD8+ T cell infiltration and activation, and, ultimately, reduced tumor growth.

Paragonix Unveils PancreasPak™: The World’s First FDA-Cleared Preservation Device for Donor Pancreas Transplantation

[Paragonix Technologies, Inc.] Paragonix Technologies, Inc. announced the PancreasPakOrgan Preservation System, the first FDA-cleared device designed to protect and monitor donor pancreases during transportation.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

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