Loss of the Wild-Type KRAS Allele Promotes Pancreatic Cancer Progression through Functional Activation of YAP1

Researchers showed that the restoration of wild type (WT) KRAS expression in human pancreatic ductal adenocarcinoma (PDAC) cell lines with LOH at KRAS significantly attenuated the malignancy of PDAC cells both in vitro and in vivo, demonstrating a tumor-suppressive role of the WT KRAS allele.
[Oncogene]
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Loss of TBX3 Enhances Pancreatic Progenitor Generation from Human Pluripotent Stem Cells

TBX3 mutant human PSC lines were generated using CRISPR/Cas9 genome editing. TBX3 loss led to impaired liver differentiation and an upregulation of pancreatic gene expression, including PDX1, during a hepatocyte differentiation protocol.
[Stem Cell Reports]
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Lixte Biotechnology Announces Collaboration with Netherlands Cancer Institute (Amsterdam) and Oncode Institute (Utrecht) to Identify the Most Promising Drug Combinations for its Lead Clinical Compound, LB-100, for Cancer Treatment

Lixte Biotechnology Holdings, Inc. announced entry into a collaboration with the Netherlands Cancer Institute, Amsterdam, and Oncode Institute, Utrecht to identify the most promising drugs to be combined with LB-100, and potentially LB-100 analogues, to be used to treat a range of cancers, as well as to identify the specific molecular mechanisms underlying the identified combinations.
[Lixte Biotechnology Holdings, Inc.]
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Designing Biomaterials for the Modulation of Allogeneic and Autoimmune Responses to Cellular Implants in Type 1 Diabetes

Designing materials to decrease antigen escape, improve cell viability, and increase material compatibility are all approaches that can decrease the local release of antigen and danger signals into the implant microenvironment.
[Acta Biomaterialia]
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Proteotranscriptomic Classification and Characterization of Pancreatic Neuroendocrine Neoplasms

Transcriptomic analysis of 84 PNEN specimens, drawn from two cohorts, was substantiated with proteomic profiling and identifies four subgroups: Proliferative, PDX1-high, Alpha cell-like and Stromal/Mesenchymal.
[Cell Reports]
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TIGER: The Gene Expression Regulatory Variation Landscape of Human Pancreatic Islets

Scientists created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating over 500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems.
[Cell Reports]
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Inhibition of JAK2/STAT3 Signaling Pathway by Panaxadiol Limits the Progression of Pancreatic Cancer

Investigators found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.
[Aging-Us]
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A 3-Dimensional Coculture Model to Visualize and Monitor Interaction Between Pancreatic Cancer and Islet β Cells

Adopting a 3D rotary cell culture system, researchers co-cultured several PDAC cell lines and MIN6 islet β cells.
[Pancreas]
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Positive Feedback between lncRNA FLVCR1-AS1 and KLF10 May Inhibit Pancreatic Cancer Progression via the PTEN/AKT Pathway

FLVCR1-AS1 expression levels in 77 pancreatic cancer tissues and matched non-tumor tissues were analyzed by qRT-PCR.
[Journal of Experimental & Clinical Cancer Research]
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Integrated Systems-Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1

Researchers observed both common and distinct patterns of glycosylation in pancreatic cancer across species. Common alterations included increased levels of α-2,3- and α-2,6-sialic acids, bisecting GlcNAc and poly-LacNAc.
[Molecular & Cellular Proteomics]
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SNAIL2 Contributes to Tumorigenicity and Chemotherapy Resistance in Pancreatic Cancer by Regulating IGFBP2

Scientists showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro and in vivo in two pancreatic cancer cell lines, KLM1 and KMP5.
[Cancer Science]
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