Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

SOX2 and OCT4 Mediate Radiation and Drug Resistance in Pancreatic Tumor Organoids

[Cell Death Discovery] Investigators treated pancreatic tumor organoids with 4 or 8 Gy of radiation, 10 μM of 5-Fluorouracil, and 100 μM 3-Bromopyruvate, a promising anti-cancer drug, as a single treatment modalities, and in combination with RT.

Progesterone Receptor Potentiates Macropinocytosis through CDC42 in Pancreatic Ductal Adenocarcinoma

[Oncogenesis] The authors found that progesterone receptor (PGR), a steroid-responsive nuclear receptor, is highly expressed in PDAC tissues obtained from both patients and transgenic LSL-KrasG12D/+; LSL-Trp53R172H/+; PDX1-cre mice.

Redox Regulation of m6A Methyltransferase METTL3 in β-Cells Controls the Innate Immune Response in Type 1 Diabetes

[Nature Cell Biology] Investigators reported that N6-methyladenosine (m6A) was an adaptive β-cell safeguard mechanism that controled the amplitude and duration of the antiviral innate immune response at type 1 diabetes onset.

Role of CFTR in Diabetes-Induced Pancreatic Ductal Fluid and HCO3− Secretion

[Journal Of Physiology] The authors investigated the effect of diabetes on ductal function. Diabetes was induced in wild-type and cystic fibrosis transmembrane conductance regulator knockout mice following an i.p. administration of streptozotocin.

Diabetes Research Study Evaluating a New Approach To Helping Patients Now Offered in Warwick

[Fractyl Health (BusinessWire, Inc.)] A new diabetes research study is available in Warwick, R.I., to evaluate a non-drug procedure that may help improve blood sugar without increasing medicines or insulin. The combination of diabetes and obesity significantly increases one’s risk of heart attacks, stroke, liver disease, kidney disease, and other serious health problems.

Genetic Architecture and Biology of Youth-Onset Type 2 Diabetes

[Nature Metabolism] Scientists reported a detailed genetic characterization of youth-onset T2D by analysing exome sequences and common variant associations for 3,005 individuals with youth-onset T2D and 9,777 adult control participants matched for ancestry, including both males and females.

University of Cincinnati Cancer Center First in Midwest to Open Pancreatic Cancer Vaccine Trial

[University of Cincinnati] The University of Cincinnati Cancer Center is the first site in the Midwest enrolling patients in a new Phase II clinical trial testing a vaccine to treat pancreatic cancer.

A Synergistic Two-Drug Therapy Specifically Targets a DNA Repair Dysregulation That Occurs in p53-Deficient Colorectal and Pancreatic Cancers

[Cell Reports Medicine] Scientists reported a therapeutic strategy for p53Mut tumors based on abnormalities in the DNA repair response. Investigation of DNA repair upon challenge with thymidine analogs revealed a dysregulation in DNA repair response in p53Mut cells that led to accumulation of DNA breaks.

Minute Virus of Mice Shows Oncolytic Activity against Pancreatic Cancer Cells Exhibiting a Mesenchymal Phenotype

[Molecular Therapy Oncology] Researchers reported that fibrotropic minute virus of mice prototype specifically infected, replicated in and killed pancreatic cancer cells from murine and human origin with a mesenchymal, basal-like profile, while sparing cancer cells with an epithelial phenotype.

Empowering Pancreatic Tumor Homing with Augmented Anti-Tumor Potency of CXCR2-Tethered CAR-NK Cells

[Molecular Therapy Oncology] Pancreatic cancer cells were found to secrete high levels of ligands for C-X-C motif receptor 1 (CXCR1) and CXCR2. Subsequently, the authors generated anti-mesothelin CAR-NK cells incorporating CXCR1 or CXCR2 and evaluated their tumor-killing abilities in 2D cancer cell co-culture and 3D tumor-mimetic organoid models.

Fusion Genes in Pancreatic Tumors

[Trends In Cancer] The authors review the existing literature on the role of fusion genes in pancreatic tumors and their clinical potential as effective biomarkers and therapeutic targets.

Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice

[Diabetes] Scientists demonstrated that mAb43 binds to exocytotic sites on the β-cell surface, masking the antigenic exposure of ZnT8 and insulin following glucosestimulated insulin secretion.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.