Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Apelin-Driven Endothelial Cell Migration Sustains Intestinal Progenitor Cells and Tumor Growth

May 16, 2022

[Nature Cardiovascular Research] Scientists report that in colorectal cancer, expansion of the stem/progenitor pool in intestinal crypts required VEGFA-independent growth and remodeling of blood vessels.

Syndecan-2 Selectively Regulates VEGF-Induced Vascular Permeability

May 16, 2022

[Nature Cardiovascular Research] Researchers reported that a proteoglycan, Syndecan-2, regulated the interaction between a transmembrane phosphatase, DEP1, and VEGFR2 by controlling cell surface levels of DEP1.

Endothelial ETS1 Inhibition Exacerbate Blood–Brain Barrier Dysfunction in Multiple Sclerosis through Inducing Endothelial-to-Mesenchymal Transition

May 16, 2022

[Cell Death & Disease] Investigators demonstrated that endothelial-to-mesenchymal transition accompanied the blood–brain barrier dysfunction in several neurological disorders, especially in multiple sclerosis.

Aspartate Metabolism in Endothelial Cells Activates the mTORC1 Pathway to Initiate Translation during Angiogenesis

May 16, 2022

[Developmental Cell] The authors showed in both human cell lines and mouse models that during developmental and pathological angiogenesis, endothelial cells used glutaminolysis-derived glutamate to produce aspartate via aspartate aminotransferase.

Yeast Beta-Glucan Mediates Histone Deacetylase 5-Induced Angiogenesis in Vascular Endothelial Cells

May 16, 2022

[International Journal of Biological Macromolecules] Scientists investigated the correlation between β-glucan and histone deacetylase 5 (HDAC5) in HUVECs, revealing the role of β-glucan in angiogenesis, and confirmed that HDAC5 was phosphorylated by β-glucan stimulation and released from the nucleus to the cytoplasm.

Pro-Angiogenic Role of ZEB1 in Skin Wound Healing by Upregulating VEGFA via microRNA-206 Suppression

May 16, 2022

[Experimental Dermatology] Cell and animal experiments were implemented to figure out whether zinc finger E-box binding homeobox 1 (ZEB1) orchestrated angiogenesis during skin wound healing.

Organ-Specific Endothelial Cell Heterogenicity and Its Impact on Regenerative Medicine and Biomedical Engineering Applications

May 16, 2022

[Advanced Drug Delivery Reviews] The authors highlight the main differences between different endothelial cell (EC) types, briefly summarize their different characteristics, and focus on the use of ECs in in vitro models.

New Insight into Dyslipidemia-Induced Cellular Senescence in Atherosclerosis

May 16, 2022

[Biological Reviews] Scientists summarize the current evidence for dyslipidemia-induced cellular senescence during atherosclerosis, with a focus on low-density lipoprotein and its modifications, hydrolysate of triglyceride-rich lipoproteins, and high-density lipoprotein.

Oxurion Announces Top-Line Results from Part A of Phase II INTEGRAL Trial Evaluating THR-687 for Treatment of Diabetic Macular Edema (DME)

May 16, 2022

[Oxurion NV] Oxurion NV announced top-line results from Part A of its Phase II trial of THR-687, an integrin antagonist, for the treatment of DME.

Mast Cell Infiltration of the Choroid and Protease Release Are Early Events in Age-Related Macular Degeneration Associated with Genetic Risk at Both Chromosomes 1q32...

May 16, 2022

[Proceedings of the National Academy of Sciences of the United States of America] The authors used mass spectrometry–based quantitative proteomics to compare the proteins in human submacular stromal tissue punches from donors who were homozygous for high-risk alleles at either Chr1 or Chr10 with those from donors who had protective haplotypes at these loci, all without clinical features of age-related macular degeneration.

Travere Therapeutics Announces FDA Acceptance and Priority Review of New Drug Application for Sparsentan for the Treatment of IgA Nephropathy

May 16, 2022

[Travere Therapeutics, Inc.] Travere Therapeutics, Inc. announced the US FDA has accepted and granted Priority Review of its New Drug Application under Subpart H for accelerated approval of sparsentan for the treatment of IgA nephropathy.

Rescue of Behavioral and Electrophysiological Phenotypes in a Pitt-Hopkins Syndrome Mouse Model by Genetic Restoration of Tcf4 Expression

May 16, 2022

[eLife] Investigators performed proof-of-concept viral gene therapy experiments using a conditional Tcf4 mouse model of Pitt-Hopkins syndrome and found that postnatally reinstating Tcf4 expression in neurons improved anxiety-like behavior, activity levels, innate behaviors, and memory.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.