Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

The Role of RAS Oncogenes in Controlling Epithelial Mechanics

[Trends in Cell Biology] Investigators discuss the role of oncogenic RAS in controlling mechanical cell phenotypes, and how these mechanical changes promote oncogenic transformation in single cells and tissues.

90 New Grants To Outsmart Cancer, Totalling $10.8 Million

[Cancer Research Society] The Cancer Research Society is awarding 90 new research grants valued at $10.8 million as part of its annual competition. It is an all-time record for the organization for a second year in a row. The grants are awarded to some of the most promising cancer research projects in Canada.

Functional Precision Cancer Medicine: Drug Sensitivity Screening Enabled by Cell Culture Models

[Trends in Pharmacological Sciences] The authors provide an overview of the current state of functional precision medicine, highlight advances for drug-sensitivity screening enabled by cell culture models, and discuss how artificial intelligence can be coupled to functional precision medicine to guide patient stratification.

The Evolving View of Thermogenic Fat and Its Implications in Cancer and Metabolic Diseases

[Signal Transduction and Targeted Therapy] The authors enumerate current knowledge about the origin and physiological functions of thermogenic fat. In addition, they discuss the multiple roles of thermogenic adipocytes in different tumors.

Targeting Pancreatic β Cells for Diabetes Treatment

[Nature Metabolism] The authors highlight recent advances toward the development of diabetes therapies that target β cells to enhance proliferation, redifferentiation and protection from cell death and/or enable selective killing of senescent β cells.

Interplays of Glucose Metabolism and Kras Mutation in Pancreatic Ductal Adenocarcinoma

[Cell Death & Disease] Scientists review convergent and diverse metabolic networks related to oncogenic KRAS mutations between PDAC initiation and progression, emphasizing the interplay among oncogenic mutations, glucose metabolic reprogramming, and the tumor microenvironment.

Islet Primary Cilia Motility Controls Insulin Secretion

[Science Advances] Scientists show that primary cilia in human and mouse pancreatic islets exhibited movement that was required for glucose-dependent insulin secretion.

Engineering of Immune Checkpoints B7-H3 and CD155 Enhances Immune Compatibility of MHC-I−/− iPSCs for β Cell Replacement

[Cell Reports] By profiling the relevant NK-activating ligands on iPSCs during in vitro differentiation into pancreatic β cells, researchers found that they express high levels of B7-H3 and CD155.

Azulene Hydrazide-Hydrazones for Selective Targeting of Pancreatic Cancer Cells

[Biomedicine & Pharmacotherapy] Scientists tested the cytotoxicity of novel azulene hydrazide-hydrazone-based chelators against pancreatic cancer cell lines (MIA PaCa-2, PANC-1, AsPC-1).

FAK Promotes Stromal PD-L2 Expression associated With Poor Survival in Pancreatic Cancer

[British Journal of Cancer] Researchers combined CRISPR, shRNA and flow cytometry with mechanistic experiments using a KrasG12Dp53R172H mouse model of pancreatic cancer and analysis of publicly available human PDAC transcriptomic datasets.

An EGFR/HER2-Targeted Conjugate Sensitizes Gemcitabine-Sensitive and Resistant Pancreatic Cancer through Different SMAD4-Mediated Mechanisms

[Nature Communications] To overcome chemoresistance in PDAC, researchers aimed to study dual-targeting ligand-based lidamycin efficacy when combined with gemcitabine and exploreed its mechanisms of action.

Biomarkers for Pancreatic Cancer Based on Tissue and Serum Metabolomics Analysis in a Multicenter Study

[Cancer Medicine] Investigators sought to identify metabolic features of PDAC and to discover early detection biomarkers for PDAC by tissue and serum metabolomics analysis.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

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