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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Glycemia Shifts Pancreatic Islet Rhythmicity by Influencing Interactions between δ Cells and α Cells
[Cell Systems] Scientists reported that a transition from hyperglycemia to euglycemia drove a coordinated shift from slow to fast islet Ca2+ oscillations (HESF) in vivo. HESF was conserved in pancreatic tissue slices but not in dispersed single β cells in vitro, linking the transition to paracrine signaling.
Gut Virome and Metabolic Associations in Patients with Acute Pancreatitis
[mSystems] Researchers comprehensively profiled virome alterations in acute pancreatitis and evaluated their associations with disease severity, etiology, and clinical parameters.
Spatially-Resolved Subtype Progression Reveals Metabolic Vulnerabilities in Pancreatic Ductal Adenocarcinoma
[Molecular Cancer] The authors demonstrated that metabolic identity, spatial context, and tumor–stroma crosstalk are an inseparable triad that drives PDAC behavior.
Senescent Cancer-Associated Fibroblasts Drive Early-Stage Lymph Node Metastasis in Pancreatic Cancer through Lactate-Mediated Metabolic-Epigenetic Rewiring
[Cancer Discovery] Scientists demonstrated that senescent cancer-associated fibroblasts drive lymphatic remodeling and lymph node metastasis in early-stage PDAC.
Single-Cell Analysis of Chemotherapy-Induced Remodeling Reveals CD276-Driven Basal-Like Chemoresistance in Pancreatic Cancer
[Gastroenterology] Researchers uncovered the plasticity of PDAC tumor cell states and their interactions with the tumor microenvironment that are modified during chemotherapy of unresectable advanced PDAC, and pinpointed CD276/B7-H3 as a critical regulator and a promising therapeutic target for overcoming chemotherapy resistance.
The Vulnerabilities of Chemotherapy Resistant Pancreatic Cancer Revealed by Organoids of Pre- and Post-Neoadjuvant Therapy
[Cancer Letters] Investigators provided insights into molecular changes in PDAC during treatment process and demonstrate that albumin-bound paclitaxel and gemcitabine chemotherapy can activate the KRAS and MAPK signaling, presenting a potential target for therapeutic intervention.
NUP93 Facilitates the Nuclear Import of SOX2 to Activate G3BP1 Transcription and Impairs Gemcitabine Response in Pancreatic Cancer
[Cell Death & Disease] Scientists reported that nuclear pore protein NUP93 is upregulated in PDAC and correlates with poor patient survival.
Metabolic Plasticity in Pancreatic Ductal Adenocarcinoma Progression and Response to Treatment
[Molecular Cancer] The authors highlight that focusing on these dependencies, particularly those resulting from the distinctive metabolic interactions between cancer cells and the surrounding stroma, offers a promising strategy for overcoming treatment challenges.
Revolution Medicines Begins Treating Patients in Phase III RASolute 303 Trial Evaluating Daraxonrasib as First Line Treatment for Patients with Metastatic Pancreatic Cancer
[Revolution Medicines] Revolution Medicines announced that it has begun treating patients in RASolute 303, a global Phase III clinical trial evaluating daraxonrasib as monotherapy and in combination with chemotherapy in patients with previously untreated metastatic PDAC, a disease predominantly driven by oncogenic RAS variants.
Rationale for Multi-Epitope TGFβ Vaccination in Pancreatic Cancer: Evidence from Immunologic and Clinical Correlates
[Signal Transduction and Targeted Therapy] Scientists explored the immunogenic potential of multiple transforming growth factor beta (TGFβ)-derived epitopes and assessed the clinical relevance of TGFβ-specific T cells in PDAC patients.
Antigen-Specific Immunotherapy with a CD4+ T Cell Neoepitope Restrains CD8+ T Cell Differentiation in Murine Pancreatic Islet Grafts
[Nature Communications] Using pancreatic islet transplantation in NOD mice, investigators showed that induction of tolerance to a CD4+ T cell hybrid insulin peptide neoepitope reprograms the fate of antigen-specific CD8+ T cells within the grafts.
Targeting Prolyl 3-Hydroxylase 1 Inhibits Pancreatic Cancer Progression and Macrophage Immunity
[Nature Communications] Researchers revealed a pivotal role of Prolyl 3-hydroxylase 1 in pancreatic ductal adenocarcinoma using transcriptome sequencing, proteomic analyses and engineered mouse model.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
