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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Differential Mirroring Between In Vivo Insulin Secretion and Ex Vivo Islet Function in Individuals with and Without Diabetes
[Metabolism Clinical and Experimental] Researchers studied 63 individuals undergoing partial pancreatectomy who underwent preoperative OGTT with model-based assessment of β cell function and provided pancreatic tissue for ex vivo islet isolation and glucose stimulation.
3D Epigenomic Remodelling Mediated by Foxa1 Drives Gemcitabine Resistance in Pancreatic Cancer
[Cancer Letters] Scientists established Foxa1-orchestrated enhancer reprogramming as a fundamental mechanism of gemcitabine resistance and unveil a promising epigenetic therapy to restore treatment efficacy in PDAC.
Developmental Control of DNA Damage Responses in α- and β-Cells Shapes the Selective β-Cell Susceptibility in Diabetes
[Diabetes] Scientists demonstrated that replication introduces a window of genomic vulnerability in both α- and β-cells during neonatal growth, with α-cells exhibiting higher replication rates and DNA damage.
HDAC5 Depletion Promotes Hyper-Acetylation of FOXA1 and Potentiates HIF1α Transcriptional Activation in Pancreatic Cancer
[Molecular Cell] Investigators demonstrated that histone deacetylase 5 (HDAC5) mediates the deacetylation of forkhead box A1 (FOXA1) at lysine residue 270, leading to repression of FOXA1’s global chromatin occupancy.
Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer
[Cancer Immunology Research] The authors establish cancer-associated fibroblast-stratified ductal spatial architecture as a fundamental determinant of immune exclusion in PDAC.
GSTT1 Promotes Stemness and FGFR Inhibitor Sensitivity in Pancreatic Cancer through Regulation of CD133 (PROM1)
[Cancer Letters] Using a mCherry-tagged Gstt1 reporter system in metastatic murine PDAC cells, investigators enriched for Gstt1High cells and observed increased tumor sphere formation, accompanied by upregulation of stemness-associated genes including PROM1 (CD133) and activation of Wnt and FGF signaling pathways.
Ferroptosis at the Intersection of Metabolism and Immunity in Pancreatitis and Pancreatic Cancer
[Seminars in Immunology] Scientists discuss how ferroptosis shapes immune responses in pancreatitis and pancreatic cancer and examine the factors that determine whether it promotes inflammation, antitumor immunity, or immune tolerance.
Revolution Medicines’ New Drug Application for Daraxonrasib Accepted for Review by U.S. FDA for Previously Treated Metastatic Pancreatic Cancer
[Revolution Medicines, Inc.] Revolution Medicines, Inc. announced that the US FDA accepted for review the company’s New Drug Application for daraxonrasib, an oral RAS(ON) multi-selective inhibitor, for previously treated metastatic PDAC.
Resolving Human α versus β Cell Fate Allocation for the Generation of Stem Cell-Derived Islets
[Nature Communications] Researchers uncovered human-specific mechanisms that govern α and β cell fate allocation, advancing the generation of stem cell-derived islets for diabetes research and cell therapy.
Trichostatin a Improves Impaired Autophagic Flux Associated with ERK/FoxO3a Signaling to Alleviate Acute Pancreatitis
[European Journal of Pharmacology] Scientists showed that trichostatin A alleviates acute pancreatitis by restoring autophagic flux through modulation of the ERK/FoxO3a signaling pathway.
GSK3βhigh/NFATc1high Subtype Targeting Overcomes Therapy Resistance in Pancreatic Cancer through Transcriptional Induction of Homologous Recombination Repair
[Gut] Investigators identified a GSK3βhigh/NFATc1high subtype of pancreatic cancer that drives DNA repair and cisplatin resistance, revealing a targetable vulnerability for precision therapy.
LY6D Identifies Persistent Stem-Like Cells Driving Pancreatic Tumourigenesis
[Gut] The authors revealed that LY6D marks a persistent gastric-like cell state that drives pancreatic cancer initiation and metastasis.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
