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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Metastatic Heterogeneity in Pancreatic Cancer: Mechanisms and Opportunities for Targeted Intervention
[Journal of Clinical Investigation] The author examines how tumor-stroma crosstalk mechanisms shape metastatic progression in PDAC and provides a framework for understanding why conventional therapies often fail against metastatic disease.
Localized GLP1 Receptor Pre-Internalization Directs Pancreatic Alpha Cell to Beta Cell Communication
[Cell Metabolism] Researchers showed that the glucagon-like peptide-1 (GLP1) receptor is enriched as nanodomains on beta cell membranes that contact alpha cells, in keeping with increased single-molecule transcript expression.
Pancreatic β-cell Regeneration In Situ by the ALK3 Agonist THR-123
Scientists tested the ability of THR-123, a cyclic peptide with BMP-7-like activity, to regenerate β-cell mass in diabetic mice.
[Nature Communications] Full Article
Pancreatic Islet β-cell Subtypes are Derived from Biochemically-Distinct and Nutritionally-Regulated Islet Progenitors
Researchers showed that islet progenitors with distinct gene expression and DNA methylation patterns produced β-cell subtypes of different secretory function, proliferation rate, and viability...
Non-Canonical ALK7 Pathways Promote Pancreatic Cancer Metastasis Through β-Catenin/MMP-Mediated Basement Membrane Breakdown and Intravasation
[Molecular Cancer] Researchers identify two distinct but interconnected activin receptor-like kinase 7 (ALK7)-driven non-canonical pathways that promote PDAC dissemination.
TP53 Missense-Specific Transcriptional Plasticity Drives Resistance against Cell Cycle Inhibitors in Pancreatic Cancer
[Science Advances] Integrating multicenter patient data and multi-omics, scientists reported that the misp53R273H/C mutant is associated with cell cycle progression and a basal-like state compared to the misp53R248W/Q mutant.
METTL3/IGF2BP3 Mediates ORC6 Via N6-Methyladenosine Modification to Promote the Progression of Pancreatic Ductal Adenocarcinoma
[Gene] Scientists validated the role of origin recognition complex (ORC) 6 in PDAC and supported the hypothesis that the METTL3/IGF2BP3/ORC6/p53 axis may be a novel therapeutic target for PDAC, and inhibiting this axis may be an advantageous therapeutic strategy for curing PDAC.
Phase I Trial of HR070803 (an Irinotecan Liposome) in Combination With 5-Fluorouracil, Leucovorin, and Oxaliplatin for Untreated Advanced, or Metastatic Pancreatic Ductal Adenocarcinoma
[BMC Medicine] Investgigators assessed the safety, preliminary antitumor activity, and pharmacokinetics of HR070803 in combination with 5-FU/LV and oxaliplatin for treatment-naive patients with unresectable locally advanced or metastatic PDAC.
Development of [18F]AlF-RESCA-H006 As a Novel Molecular Probe for 5T4 Tumor Imaging and Exploration of Its Application in Pancreatic Adenocarcinoma
[Molecular Pharmaceutics] Researchers confirmed the overexpression of 5T4 protein in tumor samples of pancreatic adenocarcinoma compared with the corresponding paraneoplastic tissue.
Nigericin Suppresses the Wnt/β-Catenin Signaling in Pancreatic Cancer Through Targeting Pre-Mir-374b-PRKCA/HBP1 Axis
[Molecular Carcinogenesis] Pancreatic cancer cells were exposed to increasing concentrations of nigericin at different time periods, and the corresponding 50% inhibiting concentration values were calculated.
Targeting MXD1 Sensitises Pancreatic Cancer to Trametinib
[Gut] Scientists illustrated the mechanisms of resistance to trametinib in PDAC and identified trametinib resistance-associated druggable targets, thus improving the treatment efficacy of trametinib-resistant PDAC.
eEF2K Is a Poor Prognostic Factor and Novel Molecular Target in Pancreatic Cancer: Regulating Tumor Growth and Progression Via the Tumor Microenvironment
[Cell Death & Disease] Researchers reported that the expression of eukaryotic elongation factor-2 kinase (eEF2K) is associated with shorter patient survival and demonstrated that eEF2K signaling is critical for the PDAC tumor growth and is regulated by the tumor microenvironment.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
