Cdk5 Drives Formation of Heterogeneous Pancreatic Neuroendocrine Tumors

Scientists reported development of an inducible, conditional mouse model of PanNETs by using a bi-transgenic system for regulated expression of the aberrant activator of Cdk5, p25, specifically in β-islet cells.
[Oncogenesis]
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ALKBH5-Mediated m6A Demethylation of KCNK15-AS1 Inhibits Pancreatic Cancer Progression via Regulating KCNK15 and PTEN/AKT Signaling

Researchers probed the function and potential mechanism of KCNK15-AS1 in pancreatic cancer (PC) cell growth. RT-qPCR and western blot were employed to measure gene expression in PC cells.
[Cell Death & Disease]
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Tentonin 3/TMEM150C Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells

Investigators demonstrated that Tentonin 3/TMEM150C, a mechanosensitive channel, contributes to glucose-stimulated insulin secretion by mediating cation influx.
[Cell Reports]
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Diabetes Day: Israel Launches $75M. Effort to Prevent, Treat, Cure Disease

The Azrieli Faculty of Medicine at Bar-Ilan University and The Russell Berrie Foundation announced a new $75 million, comprehensive 10-year program to help transform diabetes care, with the simultaneous goal of spurring innovations in diabetes treatment and prevention that can be applied around the world.
[The Jerusalem Post]
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$4M Grant Will Help To Advance New CAR T-Cell Therapy

The California Institute for Regenerative Medicine governing board approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T-cell therapy from the laboratory into the clinic.
[Technology Networrks]
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In Vivo Bioengineering of Beta Cells with Immune Checkpoint Ligand as a Treatment for Early-Onset Type 1 Diabetes Mellitus

Investigators described a strategy that utilizes pretargeting and glycochemistry to bioengineer β cells in situ to induce β-cell-specific tolerance.
[ACS Nano]
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Type IIB PKA Is Highly Expressed in β Cells and Controls Cell Proliferation via Regulating Cyclin D1 Expression

Investigators found that the RIIB subunit of protein kinase A is expressed specifically by β cells of mouse and human islets.
[FEBS Journal]
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WFS1 Functions in ER Export of Vesicular Cargo Proteins in Pancreatic β-Cells

Researchers showed that ER to Golgi transfer of vesicular cargo proteins requires WFS1, an endoplasmic reticulum (ER)-associated membrane protein whose loss of function led to Wolfram syndrome.
[Nature Communications]
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Drug-Dependent Morphological Transitions in Spherical and Worm-Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs

It was observed that poly(2-oxazoline)-based polymeric micelles could be elongated over time from a spherical structure to worm-like structure, with elongation influenced by several conditions, including the amount and type of drug loaded into the micelles.
[Small]
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CHK1 Protects Oncogenic KRAS-Expressing Cells from DNA Damage and Is a Target for Pancreatic Cancer Treatment

Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.
[Cell Reports]
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Glutamine Deprivation Triggers NAGK-Dependent Hexosamine Salvage

The authors identified that glutamine limitation in pancreatic ductal adenocarcinoma cells suppressed de novo hexosamine synthesis but resulted in increased free GlcNAc abundance.
[eLife]
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