Scientists confirmed the remarkable potential of Glucagon Like Peptide 1 Receptor agonist conjugation for the delivery of antisense oligonucleotides to pancreatic beta cell by effectively knocking down islet amyloid polypeptide mRNA, a potential proapoptotic target, in mice.
[Journal of the American Chemical Society]
Scientists demonstrated that the histone variant H2A.Z was highly expressed in PDAC cell lines and PDAC patients and that its overexpression correlated with poor prognosis.
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Ávila-López, P. A., Guerrero, G., Nuñez-Martínez, H. N., Peralta-Alvarez, C. A., Hernández-Montes, G., Álvarez-Hilario, L. G., Herrera-Goepfert, R., Albores-Saavedra, J., Villegas-Sepúlveda, N., Cedillo-Barrón, L., Montes-Gómez, A. E., Vargas, M., Schnoor, M., Recillas-Targa, F., & Hernández-Rivas, R. (2021). H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01664-1 Cite
Researchers showed that PDAC tumor cells present an increased sialylation that could be recognized by Siglec-7 and Siglec-9 on myeloid cells.
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Rodriguez, E., Boelaars, K., Brown, K., Eveline Li, R. J., Kruijssen, L., Bruijns, S. C. M., van Ee, T., Schetters, S. T. T., Crommentuijn, M. H. W., van der Horst, J. C., van Grieken, N. C. T., van Vliet, S. J., Kazemier, G., Giovannetti, E., Garcia-Vallejo, J. J., & van Kooyk, Y. (2021). Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. Nature Communications, 12(1), 1270. https://doi.org/10.1038/s41467-021-21550-4 Cite
The authors evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor to maintain glucose homeostasis in type 1 diabetic rodents.
[Proceedings of the National Academy of Sciences of the United States of America]
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Wang, M.-Y., Dean, E. D., Quittner-Strom, E., Zhu, Y., Chowdhury, K. H., Zhang, Z., Zhao, S., Li, N., Ye, R., Lee, Y., Zhang, Y., Chen, S., Yu, X., Leonard, D. C., Poffenberger, G., Deylen, A. V., McCorkle, S. K., Schlegel, A., Sloop, K. W., … Holland, W. L. (2021). Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets. Proceedings of the National Academy of Sciences, 118(9). https://doi.org/10.1073/pnas.2022142118 Cite
Cetuximab‐conjugated maleimide‐polyethylene glycol‐chlorin e6 (CMPC) was designed to strengthen its antitumor efficacy. With strong affinity for epidermal growth factor receptor overexpressing Aspc‐1 cells, CMPC with laser exerted the greatest cytotoxicity and induction of immunogenic cell death.
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Immune Stimulating Antibody‐Photosensitizer Conjugates via Fc‐Mediated Dendritic Cell Phagocytosis and Phototriggered Immunogenic Cell Death for KRAS‐Mutated Pancreatic Cancer Treatment - Kim - - Small - Wiley Online Library. (n.d.). Retrieved February 23, 2021, from https://onlinelibrary.wiley.com/doi/10.1002/smll.202006650 Cite
Scientists investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.
[Nutrition and Cancer]
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Terasaki, M., Takahashi, S., Nishimura, R., Kubota, A., Kojima, H., Ohta, T., Hamada, J., Kuramitsu, Y., Maeda, H., Miyashita, K., Takahashi, M., & Mutoh, M. (2021). A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. Nutrition and Cancer, 0(0), 1–16. https://doi.org/10.1080/01635581.2020.1863994 Cite
Researchers found that a Ser552Ala version of β-catenin attenuated glucose stimulated insulin secretion indicating a functional role for Ser552 phosphorylation of β-catenin in insulin secretion.
Scientists showed that ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) expression was significantly increased in the pancreatic cancer tissues and cells, and that knocking down UCHL3 noticeably inhibited cell viability and aerobic glycolysis.
[Clinical and Translational Oncology]
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The authors compared and discussed two strategies for culturing human pancreatic β-cells derived from human induced pluripotent stem cells in microfluidic biochips.
[Journal of Biotechnology]
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Essaouiba, A., Jellali, R., Shinohara, M., Scheidecker, B., Legallais, C., Sakai, Y., & Leclerc, E. (2021). Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment. Journal of Biotechnology. https://doi.org/10.1016/j.jbiotec.2021.02.009 Cite
Interleukin (IL)‐33 was highly expressed in the skin and pancreatic epithelial cells in chronic inflammation, leading to a markedly repressed Smad6 expression as well as dramatically upregulated p‐SMAD2/3 and p‐SMAD1/5 in the epithelial cells.
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Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation | The EMBO Journal. (n.d.). Retrieved February 23, 2021, from https://www.embopress.org/doi/abs/10.15252/embj.2020106151 Cite
JDRF announced, in collaboration with the Harvard Stem Cell Institute, the launch of the JDRF Center of Excellence in New England.
[JDRF (PR Newswire, LLC)]
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