Category Archives: Pancreatic Cell

Pancreatic Cell News is an online publication and email newsletter providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
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Pancreatic Cell News is a weekly newsletter that highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

Cdk5 Drives Formation of Heterogeneous Pancreatic Neuroendocrine Tumors

Scientists reported development of an inducible, conditional mouse model of PanNETs by using a bi-transgenic system for regulated expression of the aberrant activator of Cdk5, p25, specifically in β-islet cells.
[Oncogenesis]
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ALKBH5-Mediated m6A Demethylation of KCNK15-AS1 Inhibits Pancreatic Cancer Progression via Regulating KCNK15 and PTEN/AKT Signaling

Researchers probed the function and potential mechanism of KCNK15-AS1 in pancreatic cancer (PC) cell growth. RT-qPCR and western blot were employed to measure gene expression in PC cells.
[Cell Death & Disease]
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Tentonin 3/TMEM150C Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells

Investigators demonstrated that Tentonin 3/TMEM150C, a mechanosensitive channel, contributes to glucose-stimulated insulin secretion by mediating cation influx.
[Cell Reports]
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Diabetes Day: Israel Launches $75M. Effort to Prevent, Treat, Cure Disease

The Azrieli Faculty of Medicine at Bar-Ilan University and The Russell Berrie Foundation announced a new $75 million, comprehensive 10-year program to help transform diabetes care, with the simultaneous goal of spurring innovations in diabetes treatment and prevention that can be applied around the world.
[The Jerusalem Post]
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$4M Grant Will Help To Advance New CAR T-Cell Therapy

The California Institute for Regenerative Medicine governing board approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T-cell therapy from the laboratory into the clinic.
[Technology Networrks]
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In Vivo Bioengineering of Beta Cells with Immune Checkpoint Ligand as a Treatment for Early-Onset Type 1 Diabetes Mellitus

Investigators described a strategy that utilizes pretargeting and glycochemistry to bioengineer β cells in situ to induce β-cell-specific tolerance.
[ACS Nano]
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Type IIB PKA Is Highly Expressed in β Cells and Controls Cell Proliferation via Regulating Cyclin D1 Expression

Investigators found that the RIIB subunit of protein kinase A is expressed specifically by β cells of mouse and human islets.
[FEBS Journal]
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WFS1 Functions in ER Export of Vesicular Cargo Proteins in Pancreatic β-Cells

Researchers showed that ER to Golgi transfer of vesicular cargo proteins requires WFS1, an endoplasmic reticulum (ER)-associated membrane protein whose loss of function led to Wolfram syndrome.
[Nature Communications]
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Drug-Dependent Morphological Transitions in Spherical and Worm-Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs

It was observed that poly(2-oxazoline)-based polymeric micelles could be elongated over time from a spherical structure to worm-like structure, with elongation influenced by several conditions, including the amount and type of drug loaded into the micelles.
[Small]
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CHK1 Protects Oncogenic KRAS-Expressing Cells from DNA Damage and Is a Target for Pancreatic Cancer Treatment

Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.
[Cell Reports]
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Glutamine Deprivation Triggers NAGK-Dependent Hexosamine Salvage

The authors identified that glutamine limitation in pancreatic ductal adenocarcinoma cells suppressed de novo hexosamine synthesis but resulted in increased free GlcNAc abundance.
[eLife]
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