CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma

Scientists identified CEACAM7 as a potential therapeutic target in PDAC and described the development of CEACAM7-targeted CAR T cells with efficacy against PDAC.
[Clinical Cancer Research]
Raj, D., Nikolaidi, M., Garces, I., Lorizio, D., Castro, N. M., Caiafa, S. G., Moore, K., Brown, N. F., Kocher, H. M., Duan, X., Nelson, B. H., Lemoine, N. R., & Marshall, J. F. (2021). CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-19-2163 Cite
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Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes

The authors discuss the roles of lncRNAs in type 2 diabetes (T2D) and cardiovascular disease (CVD) conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.
[Diagnostics]
Ismail, N., Abdullah, N., Abdul Murad, N. A., Jamal, R., & Sulaiman, S. A. (2021). Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes. Diagnostics, 11(1), 145. https://doi.org/10.3390/diagnostics11010145 Cite
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Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes

Researchers suggested that microdose lithium conferred a protective effect on islet β-cells via targeting the GSK3β-regulated Nrf2 antioxidant response and thereby ameliorated type 1 diabetes mellitus and its related kidney impairment.
[Antioxidants]
Zhang, J., Anshul, F., Malhotra, D. K., Jaume, J., Dworkin, L. D., & Gong, R. (2021). Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes. Antioxidants, 10(1), 138. https://doi.org/10.3390/antiox10010138 Cite
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The RNA-Binding Protein LARP1 Is Dispensable for Pancreatic β-Cell Function and Mass

The authors showed that La-related protein 1 (LARP1) was the most expressed LARP in mouse islets and human β-cells, being two–four-fold more abundant than LARP1B, a member of the family that also interacts with rapamycin complex 1.
[Scientific Reports]
Werneck-de-Castro, J. P., Peçanha, F. L. M., Silvestre, D. H., & Bernal-Mizrachi, E. (2021). The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass. Scientific Reports, 11(1), 2079. https://doi.org/10.1038/s41598-021-81457-4 Cite
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Ex Vivo Culture of Intact Human Patient Derived Pancreatic Tumor Tissue

To fast-track translation of therapies and to inform personalised medicine, researchers aimed to develop a whole-tissue ex vivo explant model that maintains viability, 3D multicellular architecture, and microenvironmental cues of human pancreatic tumours.
[Scientific Reports]
Kokkinos, J., Sharbeen, G., Haghighi, K. S., Ignacio, R. M. C., Kopecky, C., Gonzales-Aloy, E., Youkhana, J., Timpson, P., Pereira, B. A., Ritchie, S., Pandzic, E., Boyer, C., Davis, T. P., Butler, L. M., Goldstein, D., McCarroll, J. A., & Phillips, P. A. (2021). Ex vivo culture of intact human patient derived pancreatic tumour tissue. Scientific Reports, 11(1), 1944. https://doi.org/10.1038/s41598-021-81299-0 Cite
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Aberrant Development of Pancreatic Beta Cells Derived from Human iPSCs with FOXA2 Deficiency

Researchers generated induced pluripotent stem cells (iPSCs) from a patient with FOXA2 haploinsufficiency followed by beta-cell differentiation to understand the role of FOXA2 during pancreatic beta-cell development.
[Cell Death & Disease]
Elsayed, A. K., Younis, I., Ali, G., Hussain, K., & Abdelalim, E. M. (2021). Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency. Cell Death & Disease, 12(1), 1–17. https://doi.org/10.1038/s41419-021-03390-8 Cite
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ERYTECH Announces First Patient Enrolled in a Phase I Investigator Sponsored Trial of Eryaspase in First-Line Pancreatic Cancer

Erytech Pharma S.A. announced the first patient enrolled in a Phase I investigator sponsored trial, named rESPECT, of its lead product eryaspase for the first-line treatment of pancreatic cancer.
[Erytech Pharma S.A.]
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Dopamine Improves Chemotherapeutic Efficacy for Pancreatic Cancer by Regulating Macrophage-Derived Inflammations

The roles and mechanisms of dopamine to affect the chemotherapeutic efficacy for pancreatic cancer were studied. Multi-omics results revealed that there was a tumor-promoting vicious cycle involving murine pancreatic cancer cells and tumor-associated macrophages.
[Cancer Immunology Immunotherapy]
Liu, Q., Zhang, R., Zhang, X., Liu, J., Wu, H., Li, Y., Cui, M., Li, T., Song, H., Gao, J., Zhang, Y., Yang, S., & Liao, Q. (2021). Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-020-02816-0 Cite
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Essential Roles of Insulin and IGF-1 Receptors during Embryonic Lineage Development

To directly define the roles of insulin and IGF-1 receptors in the maintenance of pluripotency and differentiation of stem cells, scientists knocked out both the receptors in induced pluripotent stem cells.
[Molecular Medicine]
Okawa, E. R., Gupta, M. K., Kahraman, S., Goli, P., Sakaguchi, M., Hu, J., Duan, K., Slipp, B., Lennerz, J. K., & Kulkarni, R. N. (2021). Essential roles of insulin and IGF-1 receptors during embryonic lineage development. Molecular Metabolism, 101164. https://doi.org/10.1016/j.molmet.2021.101164 Cite
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SIX2 and SIX3 Coordinately Regulate Functional Maturity and Fate of Human Pancreatic β Cells

Scientists showed that shRNA-mediated SIX2 or SIX3 suppression in human pancreatic adult islets impaired insulin secretion.
[Genes & Development]
Bevacqua, R. J., Lam, J. Y., Peiris, H., Whitener, R. L., Kim, S., Gu, X., Friedlander, M. S. H., & Kim, S. K. (2021). SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells. Genes & Development. https://doi.org/10.1101/gad.342378.120 Cite
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ATDC Binds to KEAP1 to Drive NRF2-Mediated Tumorigenesis and Chemoresistance in Pancreatic Cancer

Researchers revealed that increased ataxia-telangiectasia group D-associated gene (ATDC) levels protected cancer cells from reactive oxygen species via stabilization of nuclear factor erythroid 2-related factor 2 (NRF2).
[Genes & Development]
Purohit, V., Wang, L., Yang, H., Li, J., Ney, G. M., Gumkowski, E. R., Vaidya, A. J., Wang, A., Bhardwaj, A., Zhao, E., Dolgalev, I., Zamperone, A., Abel, E. V., Magliano, M. P. D., Crawford, H. C., Diolaiti, D., Papagiannakopoulos, T. Y., Lyssiotis, C. A., & Simeone, D. M. (2021). ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Genes & Development. https://doi.org/10.1101/gad.344184.120 Cite
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