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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
O-GlcNAcylation with Ubiquitination Stabilizes METTL3 to Promoting HMGB1 Degradation to Inhibit Ferroptosis and Enhance Gemcitabine Resistance in Pancreatic Cancer
[Molecular Medicine] By means of functional gain and loss experiments, the relationship between METTL3 and gemcitabine resistance as well as ferroptosis was explored.
Emerin Is an Effector of Oncogenic KRAS-Driven Nuclear Dynamics in Pancreatic Cancer.
[JCI Insight] Using a model of PDAC, the major histological subtypes of pancreatic cancer, researchers found oncogenic mutant KRAS reduces nuclear size. Transcriptomic and protein expression analysis of mutant KRAS-expressing PDAC cells revealed differential levels of several nuclear envelope-associated genes.
ImPact Biotech Announces Treatment of First Patient in Phase 1 Clinical Trial of Padeliporfin VTP in Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma (PDAC)
[ImPact Biotech] ImPact Biotech announced that the first patient has been treated in its Phase I trial evaluating Padeliporfin vascular targeted photodynamic (VTP) in individuals with locally advanced, unresectable PDAC at the UCI Irvine Medical Center.
Neuroendocrine Cells Orchestrate Regeneration through Desert Hedgehog Signaling
[Cell] Researchers presented a mechanism wherein Desert hedgehog (Dhh), secreted from epithelial neuroendocrine cells, elicits a regenerative/protective response from mesenchymal cells.
Glucocorticoid Receptor Suppresses GATA6-Mediated RNA Polymerase II Pause Release to Modulate Classical Subtype Identity in Pancreatic Cancer
[Gut] Investigators integrated primary tumor single-cell RNA-seq, patient-derived xenograft RNA-seq, and multispectral imaging to identify master transcription factor-dependent, subtype-specific markers.
Islet Delta-Cell Architecture Is Remodelled in the Human Pancreas during Type 1 Diabetes
[Scientific Reports] Researchers determined intra-islet and extra-islet delta-cell architecture in the pancreas during long-standing type 1 diabetes or type 2 diabetes.
The E3 Ligase TRIM21 Promotes Progression of Pancreatic Ductal Adenocarcinoma by Down-Regulating TAp63α and Derepressing IL20RB
[Science Signaling] Researchers found that TAp63α inhibited cell proliferation, epithelial-mesenchymal transition, and migration in several p53-mutant PDAC cell lines.
FXYD2 Marks and Regulates Maturity of β Cells via Ion Channel-Mediated Signal Transduction
[Nature Communications] Researchers showed that FXYD Domain Containing Ion Transport Regulator 2 (FXYD2) marks and regulates functional maturation and heterogeneity of generated human islet-like organoids, by controlling the β cell transcriptome necessary for glucose-stimulated insulin secretion.
Diabetes Mellitus and the Key Role of Endoplasmic Reticulum Stress in Pancreatic β Cells
[Nature Reviews Endocrinology] The authors consider the role of β cell ER stress in common forms of diabetes mellitus and examine whether it is a cause or a consequence of these diseases.
Inhibition of NAD-GPx4 Axis and MEK Triggers Ferroptosis to Suppress Pancreatic Ductal Adenocarcinoma
[Molecular Therapy] The authors examined the roles of nicotinamide adenine dinucleotide (NAD) synthesis pathway in PDAC. Targeting the NAD synthesis pathway significantly mitigated lethality in a Drosophila model that recapitulates the PDAC genotype.
Comprehensive Sequencing Profile and Functional Analysis of IsomiRs in Human Pancreatic Islets and Beta Cells
[Diabetologia] Small RNA-seq and/or small RNA dataset analysis was conducted on human pancreatic islets and beta cells. Data were processed using the sRNAbench bioinformatics pipeline to classify isomiRs based on sequence variations.
Enterovirus VP1 Protein and HLA Class I Hyperexpression in Pancreatic Islet Cells of Organ Donors with Type 1 Diabetes
[Diabetologia] Organ donor tissues were collected by the Network for Pancreatic Organ Donors with Diabetes from donors without diabetes, donors expressing a single or multiple diabetes-associated autoantibodies, and donors with type 1 diabetes with residual insulin-containing islets or only insulin-deficient islets.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
