Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression
[Cancer Discovery] Investigators showed that healthy pancreatic mesenchyme expressed the paracrine signaling molecule KITL and identified loss of stromal KITL during tumorigenesis as tumor-promoting.
Retrograde Mitochondrial Signaling Governs the Identity and Maturity of Metabolic Tissues
[Science] The authors reported that dysfunctional mitochondrial quality control engaged a retrograde signaling program that impaired cellular identity and maturity in β-cells, hepatocytes, and brown adipocytes.
Single-Cell Atlas of Human Pancreatic Islet and Acinar Endothelial Cells in Health and Diabetes
[Nature Communications] The authors developed strategies to enrich islet-specific endothelial cells and acinar-specific endothelial cells from three human pancreases and corroborate these findings with three published pancreatic datasets.
CDCA7 Enhances STAT3 Transcriptional Activity to Regulate Aerobic Glycolysis and Promote Pancreatic Cancer Progression and Gemcitabine Resistance
[Cell Death & Disease] The authors investigated cell division cycle associated 7 (CDCA7) expression levels and biological functions in pancreatic cancer using in vitro and in vivo experiments.
Disrupting AGR2/IGF1 Paracrine and Reciprocal Signaling for Pancreatic Cancer Therapy
[Cell Reports Medicine] Scientists highlighted the critical role of anterior gradient 2 (AGR2), an endoplasmic reticulum protein disulfide isomerase, secreted by PDAC cells to activate cancer-associated fibroblasts via the Wnt signaling pathway.
Research Funding to Drive Diabetes Care Impact
[University of Waikato] Dr. Hamish Crocket will co-lead a $1.4 million project, newly funded by the Health Research Council, alongside Waikato colleague Dr. Lynne Chepulis.
Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid
[Diabetes] Researchers showed that Atf4 expression in β-cells was minimally required for glucose homeostasis in juvenile and adolescent mice but it is needed for β-cell function during aging and under obesity-related metabolic stress.
Stroma Gene Signature Predicts Responsiveness to Chemotherapy in Pancreatic Ductal Adenocarcinoma Patient-Derived Xenograft Models
[Molecular Oncology] Four PDAC patient-derived xenografts with different responses to gemcitabine plus nab-paclitaxel were studied to dissect the contribution of both tumor and host microenvironment to treatment response.
Targeting the HERG1/β1 Integrin Complex in Lipid Rafts Potentiates Statins Anti-Cancer Activity in Pancreatic Cancer
[Cell Death Discovery] Investigators provided evidence that the complex formed by the human ether-à -go-go-related gene 1 (hERG1) potassium channel and the β1 subunit of integrin receptors preferentially localized in lipid rafts in PDAC cell lines and primary samples.
Exploring the Biological Mechanism and Clinical Value of Perineural Invasion in Pancreatic Cancer
[Cancer Letters] Scientists present a comprehensive overview of the manifestations and characteristics of perineural invasion (PNI) in pancreatic cancer and summarize the molecular networks that regulate PNI.
Nutritional State-Dependent Modulation of Insulin-Producing Cells in Drosophila
[eLife] To investigate the in vivo dynamics of insulin-producing cell (IPC) activity, researchers quantified the effects of nutritional and internal state changes on IPCs using electrophysiological recordings.
Glucocorticoid Receptor Suppresses GATA6-Mediated RNA Polymerase II Pause Release to Modulate Classical Subtype Identity in Pancreatic Cancer
[Gut] Scientists integrated primary tumor single-cell RNA-seq, patient-derived xenograft RNA-seq and multispectral imaging to identify master transcription factor-dependent, subtype-specific markers.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.