Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Glycemic Control Releases Regenerative Potential of Pancreatic Beta Cells Blocked by Severe Hyperglycemia

[Cell Reports] Investigators identified and characterized heterogeneity in response to beta cell ablation. Efficient beta cell elimination leading to severe hyperglycemia, caused permanent diabetes with failed regeneration despite cell cycle engagement of surviving beta cells.

Assessment of Stromal SCD-Induced Drug Resistance of PDAC Using 3D-Printed zPDX Model Chips

[iScience] The mixture of cancer-associated fibroblasts and cancer cells were co-injected into scd-/-; prkdc-/-, or hIGF1/INS-expressing zebrafish to generate patient-derived xenograft models.

Inversago Pharma Doses First Patient in Phase II Trial of INV-202, an Oral, Peripherally-acting CB1 Inverse Agonist, in Patients with Diabetic Kidney Disease

[Inversago Pharma, Inc. (BusinessWire, Inc.)] Inversago Pharma, Inc. announced that the first patient has been dosed with INV-202 in a Phase II clinical trial in subjects with diabetic kidney disease.

Extracellular SQSTM1 Exacerbates Acute Pancreatitis by Activating Autophagy-Dependent Ferroptosis

[Autophagy] Scientists reported that extracellular SQSTM1 acted as a mediator of acute pancreatitis by enhancing the sensitivity to autophagy-dependent ferroptotic cell death.

Diphenyl Ether Derivatives as Novel GPR120 Agonists for the Treatment of Type 2 Diabetes Mellitus

[Chemistry & Biodiversity] Researchers designed and synthesized a series of novel GPR120 agonists based on the structure of TUG-891, which was the first potent and selective GPR120 agonist.

RNA Binding Protein HUD Mediates the Crosstalk between β Cells and Islet Endothelial Cells by the Regulation of Endostatin and Serpin E1 Expression

[Cell Death & Disease] Co-cultures of βTC6 cells and pancreatic islet endothelial MS1 cells were used to assess the crosstalk between β cells and islet endothelial cells, and the results showed that HuD downregulation in βTC6 cells inhibited the growth and migration of MS1 cells.

Wayne State Researchers Aim to Improve the Future of Diabetes Therapy

[Wayne State University] A team of researchers from Wayne State University received a nearly $2.7 million government grant under the auspices of the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health for the study, “Infusion device optimization by addressing root causes of the inflammatory response.”

Low-Dose IL-2 Reduces IL-21+ T Cell Frequency and Induces Anti-inflammatory Gene Expression in Type 1 Diabetes

[Nature Communications] Researchers examined the effects of interval administration of low-dose recombinant IL-2 in type 1 diabetes using high-resolution single-cell multiomics and flow cytometry on longitudinally-collected peripheral blood samples.

Advantages of the Retroperitoneal Retrocolic Space as the Transplant Site for Encapsulated Xenogeneic Islets

[Xenotransplantation] The authors tested a new polymer combination for islet encapsulation and transplantation and explored a new site for xenogeneic islet transplantation in mice.

Neuronal-Epithelial Cross-Talk Drives Acinar Specification via NRG1-ERBB3-mTORC2 Signaling

[Developmental Cell] Scientists demonstrated that neuronal-epithelial cross-talk drove acinar specification through neuregulin-ERBB3-mTORC2 signaling.

Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement

[Endocrinology] The authors highlight important findings in β-cell transdifferentiation, neogenesis, and stem cell differentiation, which have nucleated multiple promising therapeutic strategies.

Novel Histone Post-Translational Modifications in Diabetes and Complications of Diabetes: The Underlying Mechanisms and Implications

[Biomedicine & Pharmacotherapy] Scientists summarize the relationship between novel histone modifications and diabetes, mainly focusing on β-hydroxybutyrylation, propionylation, butyrylation, malonylation, and succinylation.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

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