Genome Researchers Question Security Provisions in New US Senate Bill

Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science]
Editorial
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Diabetes Center Berne Launches Its First Open Innovation Challenge and Supports the Most Promising Ideas Submitted with Coaching, Expertise and a Total of 200,000 USD in Funding

DCB is looking for innovators, co-creators, scientists and members of the diabetes community from around the world to join our open call for ideas and be part of an innovative community at the forefront of diabetes technology.
[Diabetes Center Berne (BusinessWire, Inc.)]
Press Release
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British Columbia First Province to Cover Dexcom G6 Continuous Glucose Monitoring System for People with Type 1 and Type 2 Diabetes on Intensive Insulin Therapy

Dexcom, Inc. (NASDAQ: DXCM), a leader in real-time continuous glucose monitoring (CGM), announced today that people with diabetes who are on intensive insulin therapy, age two years or older, may now be eligible for provincial coverage of the Dexcom G6 CGM System through BC PharmaCare.
[Dexcom, Inc. (BusinessWire, Inc.)]
Press Release
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Fine-Mapping, Trans-Ancestral and Genomic Analyses Identify Causal Variants, Cells, Genes and Drug Targets for Type 1 Diabetes

Researchers reported the largest and most diverse genetic study of type 1 diabetes to date, yielding 78 genome-wide-significant regions, including 36 that are new.
[Nature Genetics]
Robertson, C. C., Inshaw, J. R. J., Onengut-Gumuscu, S., Chen, W.-M., Santa Cruz, D. F., Yang, H., Cutler, A. J., Crouch, D. J. M., Farber, E., Bridges, S. L., Edberg, J. C., Kimberly, R. P., Buckner, J. H., Deloukas, P., Divers, J., Dabelea, D., Lawrence, J. M., Marcovina, S., Shah, A. S., … Rich, S. S. (2021). Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nature Genetics, 1–10. https://doi.org/10.1038/s41588-021-00880-5 Cite
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NADK Is Activated by Oncogenic Signaling to Sustain Pancreatic Ductal Adenocarcinoma

Scientists showed that oncogenic KRAS promoted protein kinase C-mediated NAD+ kinase (NADK) phosphorylation, leading to its hyperactivation, thus sustaining both NADP+ and NADPH levels in pancreatic ductal adenocarcinoma cells.
[Cell Reports]
Schild, T., McReynolds, M. R., Shea, C., Low, V., Schaffer, B. E., Asara, J. M., Piskounova, E., Dephoure, N., Rabinowitz, J. D., Gomes, A. P., & Blenis, J. (2021). NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Reports, 35(11). https://doi.org/10.1016/j.celrep.2021.109238 Cite
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Peripherally Active Dextromethorphan Derivatives Lower Blood Glucose Levels by Targeting Pancreatic Islets

Investigators showed that basic nitrogen-containing residues blocked central adverse events of Dextromethorphan without reducing its anti-diabetic effects, including the protection of human pancreatic islets from cell death.
[Cell Chemical Biology]
Scholz, O., Otter, S., Welters, A., Wörmeyer, L., Dolenšek, J., Klemen, M. S., Pohorec, V., Eberhard, D., Mrugala, J., Hamacher, A., Koch, A., Sanz, M., Hoffmann, T., Hogeback, J., Herebian, D., Klöcker, N., Piechot, A., Mayatepek, E., Meissner, T., … Lammert, E. (2021). Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2021.05.011 Cite
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Necroptosis Protects against Exacerbation of Acute Pancreatitis

Researchers found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice.
[Cell Death & Disease]
Boonchan, M., Arimochi, H., Otsuka, K., Kobayashi, T., Uehara, H., Jaroonwitchawan, T., Sasaki, Y., Tsukumo, S., & Yasutomo, K. (2021). Necroptosis protects against exacerbation of acute pancreatitis. Cell Death & Disease, 12(6), 1–13. https://doi.org/10.1038/s41419-021-03847-w Cite
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SETD4-Expressing Cells Contribute to Pancreatic Development and Response to Cerulein Induced Pancreatitis Injury

Scientists provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+ cell population.
[Scientific Reports]
Tian, J.-Z., Xing, S., Feng, J.-Y., Yang, S.-H., Ding, Y.-F., Huang, X.-T., Yang, J.-S., & Yang, W.-J. (2021). SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury. Scientific Reports, 11(1), 12614. https://doi.org/10.1038/s41598-021-92075-5 Cite
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TP53 Missense Mutations in PDAC Are Associated with Enhanced Fibrosis and an Immunosuppressive Microenvironment

Researchers suggested that missense p53 mutations might contribute to worse pancreatic ductal adenocarcinoma prognosis by promoting a more vigorous fibrotic tumor microenvironment and impeding the ability of the immune system to eliminate the cancer cells.
[Proceedings of the National Academy of Sciences of the United States of America]
Maddalena, M., Mallel, G., Nataraj, N. B., Shreberk-Shaked, M., Hassin, O., Mukherjee, S., Arandkar, S., Rotkopf, R., Kapsack, A., Lambiase, G., Pellegrino, B., Ben-Isaac, E., Golani, O., Addadi, Y., Hajaj, E., Eilam, R., Straussman, R., Yarden, Y., Lotem, M., & Oren, M. (2021). TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment. Proceedings of the National Academy of Sciences, 118(23). https://doi.org/10.1073/pnas.2025631118 Cite
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CF33-hNIS-antiPDL1 Virus Primes Pancreatic Ductal Adenocarcinoma for Enhanced Anti-PD-L1 Therapy

Oncolytic viral chimera, CF33-hNIS-antiPDL1 genetically modified to express anti-human PD-L1 antibody and CF33-hNIS-Δ without the anti-PD-L1 gene, were used to investigate the immunogenic effects of oncolytic virus and virus-delivered anti-PD-L1 in pancreatic ductal adenocarcinoma in vitro.
[Cancer Gene Therapy]
Zhang, Z., Yang, A., Chaurasiya, S., Park, A. K., Lu, J., Kim, S.-I., Warner, S. G., Yuan, Y.-C., Liu, Z., Han, H., Von Hoff, D., Fong, Y., & Woo, Y. (2021). CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy. Cancer Gene Therapy, 1–12. https://doi.org/10.1038/s41417-021-00350-4 Cite
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Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ

Scientists found that EPCAM + tumors developed in the mouse pancreas store zinc that is detectable by fluorescence-activated cell sorting using N-(6-methoxy-8-quinolyl)-p-toluenesulfonamide (TSQ), a fluorescence chelator. EPCAM + TSQ + tumor cells isolated from the mouse pancreas formed organoids in matrigel.
[Biological Trace Element Research]
Asahina, K. (2021). Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ. Biological Trace Element Research. https://doi.org/10.1007/s12011-021-02770-7 Cite
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