Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

The Peptidoglycan Recognition Protein 1 Confers Immune Evasive Properties on Pancreatic Cancer Stem Cells

[Gut] Researchers used a mouse model and primary tumour cell lines to investigate putative cancer stem cell (CSC) populations. They established peptidoglycan recognition protein 1 (PGLYRP1) as a novel CSC-associated marker crucial for immune evasion.

Allysine-Targeted Molecular MRI Enables Early Prediction of Chemotherapy Response in Pancreatic Cancer

[Cancer Research] Investigators reported the application of an allysine-targeted molecular magnetic resonance imaging probe, MnL3, to provide an early, noninvasive assessment of treatment response in PDAC. Molecular MRI with MnL3 could specifically detect and quantify fibrogenesis in PDAC xenografts.

Obg-Like ATPase 1 Exacerbated Gemcitabine Drug Resistance of Pancreatic Cancer

[iScience] Scientists investigated the molecular mechanism of obg-like ATPase 1 (OLA1) underlying gemcitabine (GEM)-induced drug resistance. An enhanced expression of OLA1 was observed in a GEM acquired resistant pancreatic cancer cell lines and in patients with pancreatic cancer.

Reg4 Deficiency Aggravates Pancreatitis by Increasing Mitochondrial Cell Death and Fibrosis

[Cell Death & Disease] Researchers investigated the contribution of Reg4 to the pathogenesis of pancreatitis and evaluated its therapeutic effects in experimental pancreatitis.

The Integrated Stress Response in Pancreatic Development, Tissue Homeostasis, and Cancer

[Gastroenterology] Scientists review what is known about the key roles that the integrated stress response (ISR) plays in the development, homeostasis, and neoplasia of the pancreas.

Ferroptosis Exacerbates Hyperlipidemic Acute Pancreatitis by Enhancing Lipid Peroxidation and Modulating the Immune Microenvironment

[Cell Death Discovery] The authors focus on the malignant development of hyperlipidemic pancreatitis with severe disease combined with the core features of ferroptosis to explore and describe the mechanism of this phenomenon and show that the activation of lipid peroxidation and the aberrant intracellular release of many inflammatory mediators during ferroptosis are the key processes that regulate the degree of disease development in patients with hyperlipidemic acute pancreatitis.

Lisata Therapeutics Receives Pediatric Investigation Plan Waiver from the European Medicines Agency for Certepetide in Pancreatic Cancer

[Lisata Therapeutics, Inc.] Lisata Therapeutics, Inc. announced that it has reached agreement with the European Medicines Agency on a Pediatric Investigation Plan for Lisata’s lead investigational product, certepetide in pancreatic cancer.

Cantex Pharmaceuticals Receives FDA Orphan Drug Designation for Azeliragon for the Treatment of Pancreatic Cancer

[Cantex Pharmaceuticals, Inc.] Cantex Pharmaceuticals, Inc. announced today that the US FDA has granted Orphan Drug Designation to Cantex’ azeliragon, a once-a-day pill, for the treatment of pancreatic cancer.

The Efficiency of Stem Cell Differentiation into Functional Beta Cells for Treating Insulin-Requiring Diabetes: Recent Advances and Current Challenges

[Endocrine] The authors review the current advances and challenges faced by stem cell differentiation into functional β-cells for diabetes treatment.

E3 Ubiquitin Ligase UBR5 Promotes Gemcitabine Resistance in Pancreatic Cancer by Inducing O-GlcNAcylation-Mediated EMT via Destabilization of OGA

[Cell Death & Disease] Investigators reported that ubiquitin-protein ligase E3 module N-recognition 5 (UBR5) was a therapeutic target against gemcitabine (GEM) resistance. Further analysis revealed that UBR5 promoted GEM resistance in pancreatic cancer cells by enhancing O-GlcNAcylation-mediated epithelial-mesenchymal transition.

3D Printed VEGF-CPO Biomaterial Scaffold to Promote Subcutaneous Vascularization and Survival of Transplanted Islets for the Treatment of Diabetes

[International Journal Of Biological Macromolecules] Investigators utilized biocompatible copolymers of L-lactide and D,L-lactide to manufacture a biomaterial scaffold with a mesh-like structure via 3D printing technology, providing a material foundation for encapsulating pancreatic islet cells.

A Mucus Production Program Promotes Classical Pancreatic Ductal Adenocarcinoma

Investigators explored intratumour heterogeneity and plasticity of cancer cell states in pancreatic dutal adenocarcinoma (PDA) in order to reveal cell state-specific regulators. They analyzed...

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.