Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Glutamine Deprivation Induces Ferroptosis in Pancreatic Cancer Cells

[Acta Biochimica et Biophysica Sinica] Scientists explored the association between ferroptosis and glutamine deprivation in pancreatic cancer. The growth of pancreatic cancer cells in culture media with or without glutamine was evaluated using Cell Counting Kit-8.

Purinergic GPCR-Integrin Interactions Drive Pancreatic Cancer Cell Invasion

[eLife] Researchers identified P2RY2 as the purinergic gene with the strongest association with hypoxia and the strongest impact on overall survival.

MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression

[Cancer Research] In pancreatic neuroendocrine tumors cells resistant to everolimus, the downregulation of DCAF7 expression overcame resistance and synergized with everolimus to suppress mTOR activation and inhibit cancer cell growth.

Phanes Therapeutics Announces First Patient Dosed in Phase I Study of PT886 for Advanced Gastric, Gastroesophageal Junction and Pancreatic Adenocarcinomas

[Phanes Therapeutics, Inc.] Phanes Therapeutics, Inc. announced that the first patient has been dosed in the phase I clinical study (NCT05482893) of PT886, a first-in-class native IgG-like bispecific antibody targeting claudin 18.2 and CD47 for the treatment of gastric, gastroesophageal junction, and PDACs.

Pancreatic Islet Cell-Type-Specific Transcriptomic Changes during Pregnancy and Postpartum

[iScience] To understand transcriptional changes driving these adaptations in β-cells and other islet cell types, researchers performed single-cell RNA sequencing on islets from virgin, late gestation, and early postpartum mice.

Monitoring Autophagic Flux In Vivo Revealed Its Physiological Response and Significance of Heterogeneity in Pancreatic Beta Cells

[Cell Chemical Biology] Scientists revealed that autophagic flux in pancreatic islets enhanced after starvation, and suppression of the flux after short-term refeeding needed more prolonged re-starvation in islets than in the other insulin-targeted organs.

Light-Stimulated Insulin Secretion from Pancreatic Islet-Like Organoids Derived from Human Pluripotent Stem Cells

[Molecular Therapy] Investigators reported a novel optogenetic regulatory system for insulin secretion in human pluripotent stem cell-derived pancreatic islet-like organoids using monster-opto-Stromal interaction molecule 1.

HMGA1 Induces FGF19 to Drive Pancreatic Carcinogenesis and Stroma Formation

[Journal of Clinical Investigation] Scientists uncovered an epigenetic program whereby High mobility group A1 (HMGA1) upregulated FGF19 during tumor progression and stroma formation.

Spontaneously Evolved Progenitor Niches Escape Yap Oncogene Addiction in Advanced Pancreatic Ductal Adenocarcinomas

[Nature Communications] By employing an inducible genetic engineered mouse model, the authors illustrated that lineage plasticity enabled advanced PDAC tumors to develop spontaneous relapse following elimination of the central oncogenic driver, Yap.

The Platelet Pannexin 1-IL-1β Axis Orchestrates Pancreatic Ductal Adenocarcinoma Invasion and Metastasis

[Oncogene] Researchers investigated the protumor mechanisms of platelets in PDAC. A Panx1 knockout tumor model and an adoptive platelet transfusion mouse model were established.

SETD8 Inhibits Ferroptosis in Pancreatic Cancer by Inhibiting the Expression of RRAD

[Cancer Cell International] The authors revealed the relationship between SETD8 and ferroptosis in pancreatic cancer and its role in pancreatic cancer to provide a possible new direction for the comprehensive treatment of pancreatic cancer.

Zinc and Iron Dynamics in Human Islet Amyloid Polypeptide-Induced Diabetes Mouse Model

[Scientific Reports] Scientists investigated the dynamics of elements in the pancreatic islets of a diabetic mouse model expressing human islet amyloid polypeptide.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.