Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Imeglimin Exerts Favorable Effects on Pancreatic β-Cells by Improving Morphology in Mitochondria and Increasing the Number of Insulin Granules

[Scientific Reports] Scientists reported that single-dose administration of imeglimin significantly augmented insulin secretion in response to glucose from islets isolated from non-diabetic mice.

Reduced Calcium Levels and Accumulation of Abnormal Insulin Granules in Stem Cell Models of HNF1A Deficiency

[Communications Biology] Using stem cell-derived pancreatic endocrine cells with hypomorphic mutations in HNF1A, the authors demonstrated that HNF1A-deficient β-cells displayed impaired basal and glucose stimulated-insulin secretion, reduced intracellular calcium levels in association with a reduction in CACNA1A expression, and accumulation of abnormal insulin granules in association with SYT13 down-regulation.

CD9 Mediates the Uptake of Extracellular Vesicles From Cancer-Associated Fibroblasts That Promote Pancreatic Cancer Cell Aggressiveness

[Science Signaling] Scientists demonstrated that blocking either CD9 or p38 MAPK signaling impaired CD9+ annexin A6 extracellular vesicle–induced cell migration and epithelial-to-mesenchymal transition in PDAC cells.

CASC9 Potentiates Gemcitabine Resistance in Pancreatic Cancer by Reciprocally Activating NRF2 and the NF-κB Signaling Pathway

[Cell Biology and Toxicology] Researchers discovered that gemcitabine upregulated the expression of Cancer susceptibility candidate 9 (CASC9) in a dose-dependent manner, partially via induction of reactive oxygen species, whereas inhibition of CASC9 expression enhanced gemcitabine-induced oxidative stress and apoptosis in pancreatic cancer cells.

PanCAN Announces Its Largest-Ever Research and Research Grants Investment

[Pancreatic Cancer Action Network] In 2022, 25 research grants have been awarded – including 16 newly awarded grants and nine extensions to support next steps of promising projects – totaling a record $10.5 million.

Reprogramming Adipose Mesenchymal Stem Cells into Islet β-Cells for the Treatment of Canine Diabetes Mellitus

[Stem Cell Research & Therapy] In this study, Pbx1, Rfx3, Pdx1, Ngn3, Pax4 and MafA were used to form a six-gene combination to efficiently reprogram adipose MSCs (aMSCs) into reprogrammed aMSCs-derived islet β-cells.

Kynurenine-3-Monooxygenase Expression Is Activated in the Pancreatic Endocrine Cells by Diabetes and Its Blockade Improves Glucose-Stimulated Insulin Secretion

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Researchers reported a remarkable induction of the kmo gene in GK islets and in human islets exposed to proinflammatory conditions. It occurred prominently in beta cells.

UF Diabetes Institute to Establish Novel Biobank to Study Cardiovascular and Kidney Disease in Diabetes

[University of Florida Health] A major step toward transforming the understanding of cardiovascular and kidney disease in the millions of Americans with diabetes occurred when the National Institutes of Health designated the University of Florida (UF) Diabetes Institute the home for a new biobank of human heart and kidney tissue.

N6-Methyladenosine RNA Demethylase FTO Regulates Extracellular Matrix-Related Genes and Promotes Pancreatic Cancer Cell Migration and Invasion

[Cancer Medicine] Cell biology function assays showed that knockdown of FTO-inhibited pancreatic cell c;ell abilities to migrate and invade in vitro.

Reprogrammed Schwann Cells Organize into Dynamic Tracks That Promote Pancreatic Cancer Invasion

[Cancer Discovery] The authors showed that Schwann cells activated by cancer cells collectively function as Tumor Activated Schwann cell Tracks that promoted cancer cell migration and invasion.

Targeting hIAPP Fibrillation: A New Paradigm To Prevent β-Cell Death?

[Biochimica Et Biophysica Acta-Biomembranes] The authors review the human islet amyloid polypeptide (hIAPP) physiology and the pathology that contributes to β-cell destruction, deciphering the various cellular steps that could be involved.

NUPR1 Protects Against hyperPARylation-Dependent Cell Death

[Communications Biology] Proteomic, cellular and biochemical analysis of the stress protein NUPR1 revealed that it bound to PARP1 into the nucleus and inhibited' PARP1 activity in vitro.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

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