Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

Beta Cell and Immune Cell Interactions in Autoimmune Type 1 Diabetes: How They Meet and Talk to Each Other

[Molecular Metabolism] Scientists discuss the environment where immune and beta cell interactions occur, the key cell types and molecules involved, and the outcomes of these interactions.

An Oleanolic Acid Derivative, K73-03, Inhibits Pancreatic Cancer Cells Proliferation In Vitro and In Vivo via Blocking EGFR/Akt Pathway

[Cell Biology International] The authors demonstrated that K73-03 effectively inhibited the cell proliferation of pancreatic cells, and induced apoptosis and autophagy of ASPC-1 cells in a dose-dependent manner.

ZNF655 Accelerates Progression of Pancreatic Cancer by Promoting the Binding of E2F1 and CDK1

[Oncogenesis] Scientists demonstrated that Zinc finger protein 655 (ZNF655) knockdown inhibited the biological progression of pancreatic cancer cells, which was characterized by weaken proliferation, enhanced apoptosis, arrested cell cycle in G2, impeded migration, and suppressed tumor growth.

Synthetic Oleanane Triterpenoid Derivative CDDO-Me Disrupts Cellular Bioenergetics To Suppress Pancreatic Ductal Adenocarcinoma via Targeting SLC1A5

[Journal of Biochemical and Molecular Toxicology] The authors verified that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) downregulated glutamine transporter SLC1A5, resulting in excessive reactive oxygen species levels that suppressed tumor growth.

Adaptation to Chronic ER Stress Enforces Pancreatic β-Cell Plasticity

[Nature Communications] Single cell RNA-sequencing analysis of islets from type 1 diabetes patients indicated severe deregulation of the chronic stress-adaptation program and revealed novel biomarkers of diabetes progression.

Current and Future Approaches for In Vitro Hit Discovery in Diabetes Mellitus

[Drug Discovery Today] High-content screening has become a strong technology in phenotypic screens because it allows comprehensive screening for the cell-modulatory activity of small molecules.

WITec Announces Paper Award 2022 Winners

[Oxford Instruments] The WITec Paper Awards 2022 have been given to scientists from the US, Germany and China, recognizing their work in cement chemistry, pharmacy and methane hydrate chemistry.

Imeglimin Exerts Favorable Effects on Pancreatic β-Cells by Improving Morphology in Mitochondria and Increasing the Number of Insulin Granules

[Scientific Reports] Scientists reported that single-dose administration of imeglimin significantly augmented insulin secretion in response to glucose from islets isolated from non-diabetic mice.

Reduced Calcium Levels and Accumulation of Abnormal Insulin Granules in Stem Cell Models of HNF1A Deficiency

[Communications Biology] Using stem cell-derived pancreatic endocrine cells with hypomorphic mutations in HNF1A, the authors demonstrated that HNF1A-deficient β-cells displayed impaired basal and glucose stimulated-insulin secretion, reduced intracellular calcium levels in association with a reduction in CACNA1A expression, and accumulation of abnormal insulin granules in association with SYT13 down-regulation.

CD9 Mediates the Uptake of Extracellular Vesicles From Cancer-Associated Fibroblasts That Promote Pancreatic Cancer Cell Aggressiveness

[Science Signaling] Scientists demonstrated that blocking either CD9 or p38 MAPK signaling impaired CD9+ annexin A6 extracellular vesicle–induced cell migration and epithelial-to-mesenchymal transition in PDAC cells.

CASC9 Potentiates Gemcitabine Resistance in Pancreatic Cancer by Reciprocally Activating NRF2 and the NF-κB Signaling Pathway

[Cell Biology and Toxicology] Researchers discovered that gemcitabine upregulated the expression of Cancer susceptibility candidate 9 (CASC9) in a dose-dependent manner, partially via induction of reactive oxygen species, whereas inhibition of CASC9 expression enhanced gemcitabine-induced oxidative stress and apoptosis in pancreatic cancer cells.

PanCAN Announces Its Largest-Ever Research and Research Grants Investment

[Pancreatic Cancer Action Network] In 2022, 25 research grants have been awarded – including 16 newly awarded grants and nine extensions to support next steps of promising projects – totaling a record $10.5 million.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

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