The authors suggested the observed therapeutic effect of lentiviral vector carrying vasoactive intestinal peptide(VIP) gene was due to the repression of diabetes-induced inflammation, its insulinotropic properties, and VIP-induced beta-cell proliferation.
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Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
Mouse and human islets were used in combination with confocal microscopy, electrophysiology, GCG immunoassays, and fluorescent thallium flux assays to assess α-cell Ca2+ handling, Vm, KATP currents, and GCG secretion.
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Zaborska, K. E., Dadi, P. K., Dickerson, M. T., Nakhe, A. Y., Thorson, A. S., Schaub, C. M., Graff, S. M., Stanley, J. E., Kondapavuluru, R. S., Denton, J. S., & Jacobson, D. A. (2020). Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry. Molecular Metabolism, 101056. https://doi.org/10.1016/j.molmet.2020.101056 Cite
Investigators found that overexpression of Go-Ichi-Ni-San 2 (GINS2) contributed to advanced clinical stage of pancreatic cancer patient and promoted epithelial–mesenchymal-transition in vitro and in vivo via specifically activating ERK/MAPK signal pathway.
[Cancer Gene Therapy]
In vitro and in vivo functional studies performed by silencing or overexpressing TET1 suggested that TET1 was able to suppress epithelial-mesenchymal transition and sensitize pancreatic ductal adenocarcinoma cells to 5FU and gemcitabine. RNA-seq, whole genome bisulfite sequencing and ChIP-seq were used to explore the TET1-associated pathway, and showed that TET1 promoted the transcription of CHL1 by binding and demethylating the CHL1 promoter, which consequently inhibits the Hedgehog pathway.
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Li, H., Jiang, W., Liu, X.-N., Yuan, L.-Y., Li, T.-J., Li, S., Xu, S.-S., Zhang, W.-H., Gao, H.-L., Han, X., Wang, W.-Q., Wu, C.-T., Yu, X.-J., Xu, H.-X., & Liu, L. (2020). TET1 downregulates epithelial-mesenchymal transition and chemoresistance in PDAC by demethylating CHL1 to inhibit the Hedgehog signaling pathway. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01407-8 Cite
The authors found that metformin suppressed HNF4G activity via AMPK-mediated phosphorylation-coupled ubiquitination degradation and inhibited in vitro invasion and in vivo metastasis of pancreatic ductal adenocarcinoma cells with SMAD4 deficiency.
[Protein & Cell]
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IL-17F possessed similar pathogenic activities to IL-17A in mouse β-cell lines and islets and was likely to be a type 17 associated pathogenic factor in type 1 diabetes.
The authors discuss the important roles of mucins that lead to the lethality of pancreatic adenocarcinoma, particularly MUC1, MUC4, MUC5AC and MUC16 in disease progression, and present a comprehensive analysis of the clinical application of mucins and their promising roles in cancer treatment.
[Journal of Cellular and Molecular Medicine]
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Mucins in pancreatic cancer: A well‐established but promising family for diagnosis, prognosis and therapy - Wang - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved August 4, 2020, from https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15684 Cite
Tyme Technologies, Inc. announced that the FDA has granted the company Orphan Drug Designation for its lead pipeline candidate, SM-88, as a potential treatment for patients with pancreatic cancer.
Genprex, Inc. announced that Dr. George K. Gittes, MD of the University of Pittsburgh, was awarded a grant of $2.59 million from the NIH National Institute of Diabetes and Digestive and Kidney Diseases.
Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
Scientists revealed an important role for EGFR–AKT–FOXO1–KLF6–E-cadherin axis in mutant p53-induced cell migration and tumor metastasis.
[Cell Death & Disease]