Pancreatic Cell News

Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.

In Depth Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Beta Cells In Vitro and In Vivo

August 17, 2022

[Frontiers in Cell and Developmental Biology] Using a 7-stage protocol, hiPSCs were differentiated into islet-like aggregates with a yield of insulin-positive beta cells comparable to that of human islets.

miR-222-3p-Containing Macrophage-Derived Extracellular Vesicles Confer Gemcitabine Resistance via TSC1-Mediated mTOR/AKT/PI3K Pathway in Pancreatic Cancer

August 17, 2022

[Cell Biology and Toxicology] Co-culture of pancreatic cancer cells with M2 macrophage-derived extracellular vesicles enriched with miR-222-3p suppressed the sensitivity to gemcitabine, accompanied by diminished apoptosis and promoted proliferation.

The Transcription Factor E2F1 Controls the GLP-1 Receptor Pathway in Pancreatic β Cells

August 16, 2022

[Cell Reports] Scientists reported that that β cell-specific genetic ablation of E2f1 impaired glucose homeostasis associated with decreased expression of the Glp-1 receptor (Glp1r) in E2f1β−/− pancreatic islets.

Lutein Inhibits IL-6 Expression by Inducing PPAR-γ Activation and SOCS3 Expression in Cerulein-Stimulated Pancreatic Acinar Cells

August 16, 2022

[Molecular Medicine Reports] Investigators reported that cerulein increased phospho‑specific forms of JAK2 and STAT3, and mRNA and protein expression of IL‑6, but decreased cytokine signaling 3 (SOCS3) levels in AR42J cells.

CDK7 Inhibition Augments Response to Multidrug Chemotherapy in Pancreatic Cancer

August 16, 2022

[Journal of Experimental & Clinical Cancer Research] Using gene knockout and pharmacological inhibition of cyclin-dependent kinase 7 (CDK7) by THZ1, the authors reported cell cycle arrest, apoptosis induction, and DNA damage through the STAT3-MCL1-CHK1 axis.

N6-Methyladenosine-Mediated CELF2 Regulates CD44 Alternative Splicing Affecting Tumorigenesis via ERAD Pathway in Pancreatic Cancer

August 16, 2022

[Cell and Bioscience] Using in vivo and in vitro experiments, the authors demonstrated that abnormal expression of (CUGBP) Elav-like family member 2 (CELF2) affected the stemness, apoptosis, and proliferation of pancreatic cancer (PC) cells.

ID1 Marks the Tumorigenesis of Pancreatic Ductal Adenocarcinoma in Mouse and Human

August 16, 2022

[Scientific Reports] Using Ingenuity Pathway Analysis analysis on the differentially expressed genes, researchers determined that EIF2 signaling was the core pathway regulating the development of PDAC.

Every Islet Matters: Improving the Impact of Human Islet Research

August 16, 2022

[Nature Metabolism] The authors overview the status of the field of human islet research, highlight the challenges and propose actions that could accelerate research progress and increase understanding of type 2 diabetes to slow its pandemic spreading.

Loss of FGFR4 Promotes the Malignant Phenotype of PDAC

August 16, 2022

[Oncogene] Scientists reported that increased proliferation of FGFR4-depleted PDAC cells correlated with hyperactivation of the mTORC1 pathway both in vitro and in vivo.

Design and Synthesis of Novel Pipernonaline Derivatives As Anti-Austerity Agents Against Human Pancreatic Cancer PANC-1 Cells

August 16, 2022

[Bioorganic & Medicinal Chemistry] Investigators demonstrated that pipernonaline, one of the components of the spice pepper, preferentially reduced the survival of human pancreatic cancer PANC-1 cells under nutrient-deprived conditions.

MiR-190 Ameliorates Glucotoxicity-Induced Dysfunction and Apoptosis of Pancreatic β-Cells by Inhibiting NOX2-Mediated Reactive Oxygen Species Production

August 16, 2022

[Peerj] Scientists identified miR-190 as a candidate regulator that could effectively restore insulin expression in NIT-1 cells under high-glucose stimulation.

Therapeutic Potential of a Water-Soluble Silver-Diclofenac Coordination Polymer on 3D Pancreatic Cancer Spheroids

August 16, 2022

[Journal of Medicinal Chemistry] A 3D model representing human pancreas/duct carcinoma and human lung adenocarcinoma was designed and applied as a clear proof of the remarkable therapeutic potential of a new coordination polymer [Ag(μ-PTA)(Df)(H2O)]n·3nH2O.

Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.