Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Engineering Large-Scale Self-Mineralizing Bone Organoids with Bone Matrix-Inspired Hydroxyapatite Hybrid Bioinks

[Advanced Materials] Bioprinted scaffolds facilitate the long-term cultivation and progressive maturation of extensive bioprinted bone organoids, foster multicellular differentiation, and offer valuable insights into the initial stages of bone formation.

Injectable In Situ Gelling Methylcellulose-Based Hydrogels for Bone Tissue Regeneration

[Journal Of Materials Chemistry B] In vitro biological characterization revealed the beneficial impact of CaP and CaPGO, indicating their potential in promoting cell adhesion, proliferation and osteogenic differentiation.

Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting BACe1-Mediated Autophagy

[Tissue Engineering And Regenerative Medicine] Knocking down Nogo-B caused the downregulation of pro-fibrotic genes and inhibited the viability of hepatic stellate cells. Nogo-B knockdown prevented CCL4-induced fibrosis, accompanied by downregulation of the extracellular matrix.

A Highly Biocompatible CE-Crosslinked Collagen Implant with Exceptional Anti-calcification and Collagen Regeneration Capabilities for Aging Skin Rejuvenation

[Journal Of Materials Chemistry B] A novel collagen crosslinking agent (CE) was synthesized through a reaction involving chitosan quaternary ammonium salt with 1,4-butanediol diglycidyl ether. Compared to collagen crosslinked with glutaraldehyde, the CE-crosslinked collagen implant exhibited notable stability and durability.

Aflatoxin B1 Inhibited the Development of Primary Myoblasts of Grass Carp (Ctenopharyngodon idella) by Degrading Extracellular Matrix

[Ecotoxicology And Environmental Safety] Scientists suggested that AFB1 damaged the cell morphology, induced oxidative damage and apoptosis, and degraded ECM components, in turn inhibiting myoblast development by activating the p38MAPK/urokinase-type plasminogen activator/matrix metalloproteinase/ECM signaling pathway.

Curcumin Regulates Pulmonary Extracellular Matrix Remodeling and Mitochondrial Function to Attenuate Pulmonary Fibrosis by Regulating the miR-29a-3p/DNMT3A Axis

[Biomedicine & Pharmacotherapy] Human pulmonary fibroblasts were transfected with miR-29a-3p, and RT-qPCR, immunostaining, and western blotting were performed to determine the expression of DNMT3A and extracellular matrix collagen-1 and fibronectin-1 levels.

Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response

[ACS Applied Materials & Interfaces] Investigators successfully validated the pivotal role of activating transcription factor 5 (ATF5) in upregulating the UPRmt, mitigating IL-1β-induced inflammation and mitochondrial dysfunction, and promoting balanced metabolism in articular cartilage ECM, proving its potential as a promising therapeutic target for osteoarthritis.

Report: Europe Leads in Number of Clinical Trials for Cystic Fibrosis, North America for AML

[Fierce Biotech] Europe launched the most clinical trials for cystic fibrosis treatments, while North America leads in those for acute myeloid leukemia, according to a pair of new global trial landscape reports announced by contract research organization Novotech. Global venture funding for R&D on treatments for both diseases topped $1 billion each over the past five years.

Epigenetic Deregulation in Breast Cancer Microenvironment: Implications for Tumor Progression and Therapeutic Strategies

[Biomedicine & Pharmacotherapy] Scientists delve into the complex connections between breast cancer treatment response, underlying epigenetic changes, and vital interactions within the tumor microenvironment.

Steering Cell Orientation Through Light-Based Spatiotemporal Modulation of the Mechanical Environment

[Biofabrication] Researchers observed that 2D stiffness micropatterns induced cardiac fibroblasts (cFBs) anisotropic alignment, independent of the stimulus timing, but dependent on the micropattern spacing. cFBs exhibited organized alignment also in response to 3D stiffness macropatterns, dependent on the stimulus timing and temporally followed by ECM co-alignment.

Blockade of TGF-β and PD-L1 by Bintrafusp Alfa Promotes Survival in Preclinical Ovarian Cancer Models by Promoting T Effector and NK Cell Responses

[British Journal Of Cancer] The authors tested whether coordinated blockade of TGF-β and PD-L1 with bintrafusp alfa could provoke anti-tumour immune responses in preclinical high-grade serous ovarian cancer models.

Federal Agency Supports Research to Improve Nanofiber Production

[Rowan University] A team of engineers from the Rowan-Virtua School of Translational Biomedical Engineering & Sciences and the Henry M. Rowan College of Engineering has developed novel technology for fabricating aligned nanofibers in continuous rolls of material.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.