In vitro, researchers found that 3D collagen culture promoted the capability of colony formation and growth in integrin β1 positive gastric cancer, whereas limited colony growth was observed in ITGB1 negative gastric cancer, suggesting the role of ITGB1 in type I collagen associated tumor progression.
In H&E stained muscle sections, the relative fractions of muscle vs extracellular matrix were determined.
[Journal of Applied Physiology]
Investigators studied the possible role and mechanism of AMOTL2 in regulating transforming growth factor-β1 (TGF-β1)-induced proliferation and extracellular matrix (ECM) deposition of airway smooth muscle cells.
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Fang, P., Deng, W., Fan, N., Shi, J., Shi, H., Ou, L., Pan, J., & Yang, S. (n.d.). AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation. Environmental Toxicology, n/a(n/a). https://doi.org/10.1002/tox.23336 Cite
Researchers explored effects of lipopolysaccharide (LPS)-pre extracellular vesicles (EVs) on chondrocyte proliferation, migration, and chondrocyte apoptosis, as well as the protective effect of LPS-pre EVs on mouse articular cartilage.
[Stem Cell Research & Therapy]
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Duan, A., Shen, K., Li, B., Li, C., Zhou, H., Kong, R., Shao, Y., Qin, J., Yuan, T., Ji, J., Guo, W., Wang, X., Xue, T., Li, L., Huang, X., Sun, Y., Cai, Z., Liu, W., & Liu, F. (2021). Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model. Stem Cell Research & Therapy, 12(1), 427. https://doi.org/10.1186/s13287-021-02507-2 Cite
The American Association for Dental Research (AADR) announced Martha Somerman, National Institutes of Health, Bethesda, Md., as the 2021 recipient of the AADR Jack Hein Public Service Award. Somerman began her dental research career analyzing links between vitamin D and bone remodeling and continued research of mineralized tissues characterizing extracellular matrix proteins from bone and their bioactive effects on osteoblasts and osteoclasts in culture.
[International & American Associations For Dental Research (EurkAlert!)]
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The American Thoracic Society (ATS) Research Program and the American Lung Association have awarded Laurie Eldredge, MD, PhD, of the University of Washington/Seattle Children’s Hospital a $100,000 Partner Grant. The ATS Research Program Partner Grants provide crucial support to talented investigators from around the world, launching careers dedicated to scientific discovery and better patient care.
[ATS Research Program (Newswise, Inc.)]
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To explore the key extracellular matrix (ECM) proteins in the maintenance of the contractile phenotype of vascular smooth muscle cells (VSMCs), investigators applied protein-protein interaction network analysis to explore novel ECM proteins associated with the VSMC phenotype.
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Mao, C., Ma, Z., Jia, Y., Li, W., Xie, N., Zhao, G., Ma, B., Yu, F., Sun, J., Zhou, Y., Cui, Q., Fu, Y., & Kong, W. (n.d.). Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.053361 Cite
Researchers investigated the comprehensive cytokine dynamics following endoscopic submucosal dissection in patients with oesophageal cancer.
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Yoshida, A., Takata, T., Kanda, T., Yamaguchi, N., Minami, H., Nakao, K., Kobayashi, S., Eguchi, S., & Isomoto, H. (2021). Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer. Scientific Reports, 11(1), 15282. https://doi.org/10.1038/s41598-021-94871-5 Cite
Scientists demonstrated that THAP1 modulated the ECM composition by regulating glycosaminoglycan catabolism within oligodendrocyte progenitor cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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Yellajoshyula, D., Pappas, S. S., Rogers, A. E., Choudhury, B., Reed, X., Ding, J., Cookson, M. R., Shakkottai, V. G., Giger, R. J., & Dauer, W. T. (2021). THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes. Proceedings of the National Academy of Sciences, 118(31). https://doi.org/10.1073/pnas.2100862118 Cite
The authors summarize the contribution of biomaterials to wound healing and skin regeneration and addresses the existing limitations in skin grafting.
The authors discuss approaches adopted to recapitulate complex tumor biology in tractable 3D models. They consider how these cell types can be sourced and combined and examine methods for the deconvolution of complex multicellular models into manageable and informative outputs.
[Trends in Cancer]