Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Pioneering Engineer-Researcher to Receive 2022 Szent-Györgyi Prize for Progress in Cancer Research

[National Foundation for Cancer Research] The National Foundation for Cancer Research (NFCR) announced today that Dr. Rakesh K. Jain has been selected to receive the 2022 Szent-Györgyi Prize for Progress in Cancer Research.

Baylor College of Medicine Recognizes Research Excellence with DeBakey Awards

[Baylor College of Medicine] Each year, Baylor College of Medicine faculty are recognized for their outstanding published scientific contributions to clinical and basic science research over the past three years through the Michael E. DeBakey MD Award for Excellence in Research.

Verteporfin Ameliorates Fibrotic Aspects of Dupuytren’s Disease Nodular Fibroblasts Irrespective the Activation State of the Cells

[Scientific Reports] Researchers investigated whether verteporfin was able to inhibit the activation and subsequent differentiation of Dupuytren’s disease nodular fibroblasts into myofibroblasts.

An Automated 3D-Printed Perfusion Bioreactor Combinable with Pulsed Electromagnetic Field Stimulators for Bone Tissue Investigations

[Scientific Reports] Investigators proposed an automated uni-/bi-directional perfusion bioreactor combinable with pulsed electromagnetic field stimulation for culturing 3D bone tissue models.

Hypoxia Mimetics Restore Bone Biomineralisation in Hyperglycaemic Environments

[Scientific Reports] The authors investigated, using an in vitro hyperglycaemia bone tissue engineering model, the differing effects of glucose levels, hypoxia, and chemicals known to stabilise HIF-1α on bone formation.

Fenretinide Combines Perturbation of Signaling Kinases, Cell-Extracellular Matrix Interactions and Matrix Metalloproteinase Activation to Inhibit Invasion in Oral Squamous Cell Carcinoma Cells

[Carcinogenesis] Scientists elucidated fenretinide’s effects on additional invasion-relevant mechanisms including matrix metalloproteinase activation and function, cell-ECM attachments, and interaction with a kinase that was essential for the epithelial-myoepithelial transformation i.e. c-Jun NH2-terminal kinase.

STAT3 in Porcine Endometrium during Early Pregnancy Induces Changes in Extracellular Matrix Components and Promotes Angiogenesis

[Biology of Reproduction] Using porcine ECM and adhesion molecule array, EGF was shown to induce changes in gene expression of ECM components: MMP1, MMP3, MMP12, LAMA1, SELL and ICAM1, which were abrogated in the presence of Stattic.

Cell Proliferation Receptor-Enhanced 3D High-Throughput Screening Model for Optimized Drug Efficacy Evaluation in Breast Cancer Cells

[Analytical Chemistry] Investigators developed a cell proliferation receptor-enhanced 3D high-throughput screening model expressing high cell proliferation receptors that was optimized by the selection of alginate as the ECM.

Mechanical Force Directs Proliferation and Differentiation of Stem Cells

[Tissue Engineering Part B-Reviews] The mechanism of mechanical regulation of stem cell proliferation and differentiation is summarized based on the pathway of force transduction, including the signal transduction from ECM to nucleus.

IGF-Binding Proteins Secreted by Cancer-Associated Fibroblasts Induce Context-Dependent Drug Sensitization of Lung Cancer Cells

[Science Signaling] Gene expression and secretome analyses of cancer-associated fibroblasts and normal lung–associated fibroblasts revealed differential abundance of insulin-like growth factors (IGFs) and IGF-binding proteins, which promoted or inhibited, respectively, signaling by the receptor IGF1R and the kinase FAK.

Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Directly Reconstruct the Functional Periodontal Tissue in a Rat Periodontal Defect Model

[Journal of Tissue Engineering and Regenerative Medicine] To develop reliable scaffold-free periodontal tissue regenerative cell therapy by MSCs/extracellular matrix complexes (C-MSCs), scientists investigated the periodontal tissue regenerative capacity of C-MSCs and the behavior of the transplanted cells.

Collagen VI Deficiency Causes Behavioral Abnormalities and Cortical Dopaminergic Dysfunction

[Disease Models & Mechanisms] A thorough behavioral characterization of Collagen VI (COL6) null mice unexpectedly revealed that COL6 deficiency led to a significant impairment in sensorimotor gating and memory/attention functions.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.