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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Infected Wound Repair Correlates with Collagen I Induction and NOX2 Activation by Cold Atmospheric Plasma
[NPJ Regenerative Medicine] Genetic and pharmacological inhibitions of NOX2 in macrophages and bioengineered skin infected with Staphylococcus aureus and treated with cold atmospheric plasma reduced intracellular oxidants and increased bacterial survival.
The Role and Regulation of Integrins in Cell Migration and Invasion
[Nature Reviews Molecular Cell Biology] Investigators discuss the diverse roles integrins have during cancer progression from cell migration across varied ECM landscapes to breaching barriers such as the basement membrane, and eventual colonization of distant organs.
Repair and Regeneration: Ferroptosis in the Process of Remodeling and Fibrosis in Impaired Organs
[Cell Death Discovery] Scientists review the intrinsic mechanisms of tissue repair and remodeling via ferroptosis in different organs and systems under various conditions, including the inflammatory response in skin wounds, remodeling of joints and cartilage, and fibrosis in multiple organs.
Collagen Denaturation in Post-Run Achilles Tendons and Achilles Tendinopathy: In Vivo Mechanophysiology and Magnetic Resonance Imaging
[Science Advances] Researchers interrogated the in vivo molecular structure changes of collagen in rat Achilles tendons following treadmill running.
LRP1 Repression by SNAIL Results in ECM Remodeling in Genetic Risk for Vascular Diseases
[Circulation Research] Investigators proposed decreased low-density lipoprotein receptor-related protein 1 (LRP1) expression in smooth muscle cells to remodel the extracellular matrix enhanced by TGF-β as a potential mechanism of this pleiotropic locus for vascular diseases.
Human Bone Tissue-Derived ECM Hydrogels: Controlling Physicochemical, Biochemical, and Biological Properties Through Processing Parameters
[Bioactive Materials] The authors examined how the physiochemical and biological properties of ECM hydrogels derived from human bone ECM could be controlled by manipulating bone powder size and ECM composition through modulation of enzyme digestion time.
Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI
[Cancer Research Communications] Researchers assessed aberrant N-glycosylation patterns and alterations in extracellular matrix proteins as potential biomarkers of predicting prostate cancer severity in a unique patient outcome cohort.
Ternary Inulin Hydrogel with Long-Term Intestinal Retention for Simultaneously Reversing IBD and Its Fibrotic Complication
[Nature Communications] Researchers introduced a probiotic inulin hydrogel loaded with polypyrrole nanozymes and antifibrotic drug pirfenidone designed for the concurrent amelioration of IBD and its fibrotic complications.
Spatial Single-Cell Protein Landscape Reveals Vimentinhigh Macrophages as Immune-Suppressive in the Microenvironment of Hepatocellular Carcinoma
[Nature Cancer] Functional studies demonstrated that vimentin (VIMhigh) macrophages enhanced the immune-suppressive activity of regulatory T cells by mechanistically increasing the secretion of interleukin-1β.
Confined Copper Depletion via a Hydrogel Platform for Reversing Dabrafenib/Cetuximab Resistance in BRAFV600E-Mutant Colorectal Cancer
[Journal of Controlled Release] Scientists developed a hydrogel platform for confined copper depletion in BRAFV600E-mutant colorectal cancer cells, which effectively reversed dabrafenib/cetuximab resistance and enhancing therapeutic efficiency.
Clinical, Mechanistic, and Therapeutic Landscape of Cutaneous Fibrosis
[Science Translational Medicine] The authors provide a framework for understanding the wide clinical spectrum, mechanisms, and management of cutaneous fibrosis encompassing a variety of matrix disorders, fibrohistiocytic neoplasms, injury-induced scarring, and autoimmune scleroses.
Tumor Microenvironment-Derived Exosomes: A Double-Edged Sword for Advanced T Cell-Based Immunotherapy
[ACS Nano] Investigators delve into the dual roles of exosomes in the tumor microenvironment, highlighting both their immunosuppressive functions and their emerging therapeutic potential.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
