Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct Interactions

The authors showed in a reconstituted in vitro system that vimentin intermediate filaments stabilized microtubules against depolymerization and supported microtubule rescue.
[Nature Communications]
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Pan-Cancer Characterization of lncRNA Modifiers of Immune Microenvironment Reveals Clinically Distinct De Novo Tumor Subtypes

The impact of lncRNA expression on immune-related molecular and cellular components in the tumor immune microenvironment (TIME) at the pan-cancer level was systematically investigated and lncRNA modifier candidates of infiltrating immune cells within the TIME were identified.
[npj Genomic Medicine]
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Genome Researchers Question Security Provisions in New US Senate Bill

Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science]
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Building a Stem Cell-Based Primate Uterus

Investigators discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organizing cultures, or by controlled assembly through microfluidic and print-based technologies.
[Communications Biology]
Bergmann, S., Schindler, M., Munger, C., Penfold, C. A., & Boroviak, T. E. (2021). Building a stem cell-based primate uterus. Communications Biology, 4(1), 1–12. https://doi.org/10.1038/s42003-021-02233-8 Cite
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Tumor Microenvironment and Radioresistance

Scientists provide an overview of the tumor microenvironment and characteristics of tumor tissues, both of which affect the malignant phenotypes and radioresistance of cancer cells.
[Experimental and Molecular Medicine]
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A Combined Biomarker Approach for Characterizing Extracellular Matrix Profiles in Acute Myocardial Infarction

The authors conducted exploratory factor analysis to examine the interrelationships between ECM biomarkers, and cluster analysis to identify if distinct ECM profiles could distinguish patient risk in acute myocardial infarction.
[Scientific Reports]
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Advanced Mycelium Materials as Potential Self-Growing Biomedical Scaffolds

Investigators demonstrated the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.
[Scientific Reports]
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Macrophage Depletion Induces Edema through Release of Matrix-Degrading Proteases and Proteoglycan Deposition

Extended antibody treatment of mice caused marked body weight gain, an indicator of enhanced body fluid retention. This was associated with an increase of ECM–remodeling metalloproteinases (MMPs), namely MMP2 and MMP3, and enhanced deposition of hyaluronan and proteoglycans, leading to skin thickening.
[Science Translational Medicine]
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ATP and Cancer Immunosurveillance

The authors discuss the molecular and cellular mechanisms through which ATP and its degradation products influence cancer immunosurveillance, with a focus on therapeutically targetable circuitries.
[EMBO Journal]
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Budding Epithelial Morphogenesis Driven by Cell-Matrix versus Cell-Cell Adhesion

Researchers performed live-organ imaging of mouse embryonic salivary glands at single-cell resolution to reveal that budding morphogenesis was driven by expansion and folding of a distinct epithelial surface cell sheet characterized by strong cell-matrix adhesions and weak cell-cell adhesions.
[Cell]
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First Patient Enrolled in Restrata® Randomized Controlled Trial

Acera Surgical, Inc. has announced its first patient enrollment in a clinical study evaluating Restrata®, Acera’s leading wound care product, for the treatment of non-healing diabetic foot ulcers.
[Acera Surgical, Inc. (PR Newswire, LLC)]
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