In cell experiments, network formation of human umbilical vein endothelial cells (HUVECs) within fibrinogen‐based hydrogels with different concentrations of hyaluronic acid (HA) were systematically studied.
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Hsu, H.-H., Ko, P.-L., Wu, H.-M., Lin, H.-C., Wang, C.-K., & Tung, Y.-C. (n.d.). Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside-Down Microfluidic Devices. Small, n/a(n/a), 2006091. https://doi.org/https://doi.org/10.1002/smll.202006091 Cite
To fast-track translation of therapies and to inform personalised medicine, researchers aimed to develop a whole-tissue ex vivo explant model that maintains viability, 3D multicellular architecture, and microenvironmental cues of human pancreatic tumours.
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Kokkinos, J., Sharbeen, G., Haghighi, K. S., Ignacio, R. M. C., Kopecky, C., Gonzales-Aloy, E., Youkhana, J., Timpson, P., Pereira, B. A., Ritchie, S., Pandzic, E., Boyer, C., Davis, T. P., Butler, L. M., Goldstein, D., McCarroll, J. A., & Phillips, P. A. (2021). Ex vivo culture of intact human patient derived pancreatic tumour tissue. Scientific Reports, 11(1), 1944. https://doi.org/10.1038/s41598-021-81299-0 Cite
The authors present a method to visualize thermal distribution with the aid of a thermally active material. An ionic liquid with lower critical solution temperature is mixed within hydrogel to demonstrate a hydrogel confined ionic system.
Scientists found that combined therapy with Asiatic Acid, a Smad7 agonist, and Naringenin, a Smad3 inhibitor, effectively retrieved the balance between Smad3 and Smad7 signaling in the TGF-β-rich tumor microenvironment and thus significantly suppressed tumor invasion and metastasis in mouse models of melanoma and lung carcinoma.
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The authors report a generalizable strategy utilizing a photomediated oxime ligation to covalently decorate naturally derived hydrogels with bioactive proteins including growth factors.
[Proceedings of the National Academy of Sciences of the United States of America]
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Investigators describe a tissue-engineered model that reproduces bone tissue complexity and bone remodeling processes with high fidelity and control. An osteoid-inspired biomaterial—demineralized bone paper—directs osteoblasts to deposit structural mineralized bone tissue and subsequently acquire the resting-state bone lining cell phenotype.
Organogenesis Holdings Inc. announced that the first patient has been enrolled in its pivotal Phase III clinical trial evaluating the safety and efficacy of ReNu®, a cryopreserved amniotic suspension allograft, for the management of symptoms associated with knee osteoarthritis. ReNu consists of amniotic fluid cells and micronized amniotic membrane and contains cellular, growth factor, and ECM components.
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Histogen Inc. announced that the US FDA has verbally notified the company that it has additional questions about the company’s Investigational New Drug application package for the planned Phase I/II clinical trial of HST-003, which is intended to evaluate the safety and efficacy of human ECM implanted within microfracture interstices and the cartilage defect in the knee to regenerate hyaline cartilage in combination with a microfracture procedure.
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Scientists recruited 33 lung cancer patients with brain oligo-metastasis to explore the genomic features and tumor immune microenvironment of the lung and brain metastasis independently.
[Cell Death & Disease]
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Song, Z., Yang, L., Zhou, Z., Li, P., Wang, W., Cheng, G., Chen, R., Chang, L., Zhang, Y., Guan, Y., Xia, X., Yi, X., Zhou, R., & Chen, M. (2021). Genomic profiles and tumor immune microenvironment of primary lung carcinoma and brain oligo-metastasis. Cell Death & Disease, 12(1), 1–10. https://doi.org/10.1038/s41419-021-03410-7 Cite
Flow cytometric analyses indicated that induction of epithelial-mesenchymal transition decreased trastuzumab binding, prior to overt loss of HER2 expression in trastuzumab-emtansine-resistant (TDM1R) cells. Kinome analyses of TDM1R cells indicated increased phosphorylation of ErbB1, ErbB4, and FGFR1.
[npj Breast Cancer]
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Akhand, S. S., Chen, H., Purdy, S. C., Liu, Z., Anderson, J. C., Willey, C. D., & Wendt, M. K. (2021). Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy. Npj Breast Cancer, 7(1), 1–11. https://doi.org/10.1038/s41523-020-00213-5 Cite
Scientists demonstratde that their integrated hybrid additive manufacturing platform offers the ability to create scaffolds with continuous physicochemical gradients, and to selectively activate or coat the scaffold surfaces.
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Sinha, R., Cámara-Torres, M., Scopece, P., Verga Falzacappa, E., Patelli, A., Moroni, L., & Mota, C. (2021). A hybrid additive manufacturing platform to create bulk and surface composition gradients on scaffolds for tissue regeneration. Nature Communications, 12(1), 500. https://doi.org/10.1038/s41467-020-20865-y Cite