Microfluidic Organ-on-Chip System for Multi-Analyte Monitoring of Metabolites in 3D Cell Cultures

Investigators developed a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cultures with fully integrated electrochemical chemo- and biosensor arrays for the energy metabolites oxygen, lactate, and glucose.
[Lab On A Chip]
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Biomaterials Direct Functional B Cell Response in a Material-Specific Manner

To probe the role of B cells in biomaterial scaffold response, scientists evaluated the B cell response to biomaterial materials implanted in a muscle wound using a biological ECM as a reference for a naturally derived material, and synthetic polyester polycaprolactone as a reference for a synthetic material.
[Science Advances]
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GlomSpheres as a 3D Co-Culture Spheroid Model of the Kidney Glomerulus for Rapid Drug-Screening

Co-cultured using a magnetic spheroid formation approach, conditionally immortalised human podocytes and glomerular endothelial cells deposited mature, organized isoforms of collagen IV and Laminin.
[Communications Biology]
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Persistent Pulmonary Pathology after COVID-19 Is Associated with High Viral Load, Weak Antibody Response, and High Levels of Matrix Metalloproteinase-9

The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19.
[Scientific Reports]
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Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration through Activated Trem2+ Macrophages

Investigators showed that collagen deposition in response to the implantation of human split-thickness skin grafts containing live cells recapitulated normal skin architecture, whereas human acellular dermal matrix grafts led to a fibrotic collagen deposition.
[Science Advances]
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Oncotelic Initiates Phase II Trial Evaluating OT-101 in Combination with KEYTRUDA® for Mesothelioma

Oncotelic Therapeutics, Inc. announced that it has submitted clinical study protocol to the US FDA for the initiation of a Phase II Trial for OT-101, the company’s TGF-β inhibitor, in combination with Anti-PD-1 as a treatment for patients with malignant pleural mesothelioma.
[Oncotelic Therapeutics, Inc.]
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G1 Therapeutics Initiates Phase II Trial to Support the Antitumor Mechanism of Action (MOA) of Trilaciclib in the Tumor Microenvironment

G1 Therapeutics, Inc. announced that the company has initiated a Phase II, single arm, open-label study of trilaciclib in patients with early-stage triple negative breast cancer designed to further investigate the role of trilaciclib in modulating the anti-tumor immune response.
[G1 Therapeutics, Inc.]
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PCI Biotech and Immunicum Announce an Extension to Their Research Collaboration to Explore Novel Cancer Vaccination Treatments

PCI Biotech Holding ASA, a cancer focused biopharmaceutical company with a unique intracellular delivery technology via Photochemical Internalisation and Immunicum AB, a biopharmaceutical company focused on hard-to-treat established tumors and the prevention of cancer recurrence, announced an extension of their current collaboration.
[PCI Biotech Holding ASA]
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Mechanistically Scoping Cell-free and Cell-Dependent Artificial Scaffolds in Rebuilding Skeletal and Dental Hard Tissues

The authors summarize two strategies in regenerative dentistry and orthopedics at the level of mechanisms.
[Advanced Materials]
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Anlotinib Induces a T Cell-Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD1 Checkpoint Blockade in Neuroblastoma

Researchers proved that anlotinib facilitated tumor vessel normalization at least partially through CD4+ T cells, reprogrammed the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME, significantly inhibited tumor growth and effectively prevented systemic immunosuppression.
[Clinical Cancer Research]
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Sequential Modulation of the Wnt/β-Catenin Signaling Pathway Enhances Tumor-Intrinsic MHC I Expression and Tumor Clearance

Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence
[Gynecological Oncology]
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