Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

3D Printed Elastomeric Biomaterial Mitigates Compaction during In Vitro Vasculogenesis

[Acta Biomaterialia] Vasculogenic hydrogels were embedded within a highly porous, biostable 3D polydimethylsiloxane scaffold.

NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases

[Journal Of Crohns & Colitis] Inhibition of NLRP3 caused significantly reduced proliferation of intestinal fibroblasts from inflammatory bowel diseases patients, which was associated with a marked decrease in production of collagen type I and type VI.

Src and TKS5 Mediated Podosome Formation in Fibroblasts Promotes Extracellular Matrix Invasion and Pulmonary Fibrosis

[Nature Communications] Increased expression of TKS5, a scaffold protein essential for the formation of podosomes, was detected in the lung tissue of Idiopathic Pulmonary Fibrosis patients and bleomycin-treated mice.

Microenvironmental Stiffness Induces Metabolic Reprogramming in Glioblastoma

[Cell Reports] Scientists demonstrated that the softer matrix microenvironment induces a shift in glioblastoma cell metabolism toward glycolysis, which manifested in lower proliferation rate and increased migration activities.

Cancer-Associated Fibroblasts Influence Wnt/PCP Signaling in Gastric Cancer Cells by Cytoneme-Based Dissemination of ROR2

[Proceedings Of The National Academy Of Sciences Of The United States Of America] By high-resolution imaging, researchers observed a direct transfer of fluorescently tagged ROR2 from cancer-associated fibroblasts to the gastric cancer cell line AGS cells by signaling filopodia, known as cytonemes.

Curved Adhesions Mediate Cell Attachment to Soft Matrix Fibres in Three Dimensions

[Nature Cell Biology] Investigators reported curvature-dependent integrin-mediated adhesions called curved adhesions. Their formation was regulated by the membrane curvatures imposed by the topography of ECM protein fibres.

Mechanical Stiffness Promotes Skin Fibrosis through Piezo1-Mediated Arginine and Proline Metabolism

[Cell Death Discovery] Investigators showed that transferring mouse dermal fibroblasts from soft to stiff substrates caused an up-regulation of arginine and proline metabolism, and that increased matrix stiffness stimulated the expression and activity of key metabolic enzymes.

The Third Dimension of Tumor Microenvironment—The Importance of Tumor Stroma in 3D Cancer Models

[Experimental Biology And Medicine] The authors focus on the description of existing 3D models, the incorporation of TME and fluidics into these models, and their perspective in the future research.

Genentech Sticks Molecular Glue Deal with Orionis for $47M Upfront

[Fierce Biotech] As well as the $47 million upfront payment, Orionis will be eligible for over $2 billion in milestone payments on top of royalties. Molecular glues are small molecules used to stabilize the interaction between two proteins that don’t typically interact.

C9orf72-ALS Human iPSC Microglia Are Pro-Inflammatory and Toxic to Co-Cultured Motor Neurons via MMP9

[Nature Communications] Scientists studied the consequences of the hexanucleotide repeat expansion mutation in C9orf72 for microglial function using human iPSC-derived microglia.

Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture

[Acta Biomaterialia] Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.

Extracellular Matrix-Induced Signaling Pathways in Mesenchymal Stem/Stromal Cells

[Cell Communication and Signaling] The authors consider the existing evidence regarded the contribution of extracellular matrix-induced intracellular signaling pathways into the regulation of stem cell differentiation focusing on MSCs as well-studied type of postnatal stem cells totally depended on signals from ECM.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.