UCLA Broad Stem Cell Research Center Receives $5 Million CIRM Grant for Research Training Program

The Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA has been awarded $5 million by the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians to become leaders in the stem cell and regenerative medicine field.
[University of California]
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Fibroblast Growth Factor 21 (FGF21) Alleviates Senescence, Apoptosis, and Extracellular Matrix Degradation in Osteoarthritis via the SIRT1-mTOR Signaling Pathway

The role of FGF21 in the progression of osteoarthritis was investigated in both in vitro and in vivo experiments. In vitro, FGF21 administration alleviated apoptosis, senescence, and ECM catabolism of the chondrocytes induced by tert-butyl hydroperoxide by mediating autophagy flux.
[Cell Death & Disease]
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A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature

Researchers evaluated matrix metalloproteinase-8 (MMP-8) as a modulator of pathogenic mechanical signaling in pulmonary arterial hypertension (PAH). MMP-8 expression was significantly increased in plasma and pulmonary arteries of pulmonary hypertension (PH) patients compared to controls and induced in the pulmonary vasculature in rodent PH models.
[American Journal of Respiratory and Critical Care Medicine]
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Rutin Inhibited the Advanced Glycation End Products-Stimulated Inflammatory Response and Extracellular Matrix Degeneration via Targeting TRAF-6 and BCL-2 Proteins in Mouse Model of Osteoarthritis

Scientists screened rutin (RT) for its activity against osteoarthritis with in vivo and in vitro models of osteoarthritis. Pretreatment of RT decreased the ECM degradation, inhibited expression of TRAF-6 and BCL-2 the NF-κB/MAPK pathway proteins.
[Aging]
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Stem Cells Immortalized by hTERT Perform Differently from Those Immortalized by SV40LT in Proliferation, Differentiation, and Reconstruction of Matrix Microenvironment

Decellularized ECM deposited by immortalized cells significantly influenced replicative senescent infrapatellar fat pad-derived stem cells in proliferation and differentiation preference, the effect of which was hinged on the approach of immortalization using either simian virus 40 large T antigen (SV40LT) or human telomerase reverse transcriptase (hTERT).
[Acta Biomaterialia]
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Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI–Mediated High-Density Lipoprotein Uptake

The authors investigated the role of adipocyte procollagen C-endopeptidase enhancer 2 (Pcpe2) in scavenger receptor class BI (SR-BI)–mediated high-density lipoprotein cholesterol uptake and contributions to adipose lipid storage.
[Arteriosclerosis Thrombosis and Vascular Biology]
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HA-Coated Collagen Nanofibers for Urethral Regeneration via In Situ Polarization of M2 Macrophages

Investigators evaluated the efficacy of hyaluronic acid (HA) functionalized collagen nanofibers in modulating the pro-healing phenotype expression of macrophages for urethral regeneration.
[Journal of Nanobiotechnology]
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The Cross Talk between Gastric Cancer Stem Cells and the Immune Microenvironment: A Tumor-Promoting Factor

Scientists provide an overview of bidirectional interactions between cancer stem cells and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.
[Stem Cell Research & Therapy]
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Optimization of Polycaprolactone – Based Nanofiber Matrices for the Cultivation of Corneal Endothelial Cells

Four groups of electrospun nanofibrous scaffolds were compared: polycaprolactone (PCL), PCL/collagen, PCL/gelatin and PCL/chitosan. Each of the scaffolds were tissue-engineered with human corneal endothelial cells and analyzed with regard to their potential application as artificial posterior lamellar grafts.
[Scientific Reports]
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Blade Therapeutics Announces Positive Data from Preclinical Drug-Drug Interaction Study of Cudetaxestat, a Non-Competitive Autotaxin Inhibitor in Clinical Development for Idiopathic Pulmonary Fibrosis (IPF)

Blade Therapeutics, Inc., a biopharmaceutical company focused on developing cutting-edge treatments for fibrotic and neurodegenerative diseases, announced positive preliminary data from a new preclinical study of cudetaxestat, an investigational non-competitive autotaxin inhibitor in clinical development for IPF.
[Blade Therapeutics, Inc.]
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Chitosan Hydrogel/3D-Printed Poly(ε-Caprolactone) Hybrid Scaffold Containing Synovial Mesenchymal Stem Cells for Cartilage Regeneration Based on Tetrahedral Framework Nucleic Acid Recruitment

A cartilage regenerative system was developed based on a chitosan hydrogel/3D-printed poly(ε‐caprolactone) hybrid containing synovial mesencymal stem cells and recruiting tetrahedral framework nucleic acid injected into the articular cavity.
[Biomaterials]
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