Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Extracellular Matrix-Induced Signaling Pathways in Mesenchymal Stem/Stromal Cells

[Cell Communication and Signaling] The authors consider the existing evidence regarded the contribution of extracellular matrix-induced intracellular signaling pathways into the regulation of stem cell differentiation focusing on MSCs as well-studied type of postnatal stem cells totally depended on signals from ECM.

Glycoprotein Injectable Hydrogels Promote Accelerated Bone Regeneration through Angiogenesis and Innervation

[Advanced Healthcare Materials] Investigators reported the role of mucin in ECM formation validated by RNA sequencing analysis of human bone marrow derived mesenchymal stem cells.

Adipose-Derived Mesenchymal Stem Cell-Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin Regeneration

[Advanced Science] The development of a novel ECM hydrogel@exosomes was reported, which entailed incorporation of adipose-derived mesenchymal stem cell-derived exosomes into an ECM hydrogel.

Exploring Mechanical Responses of Cells to Geometric Information Using Micropatterned DNA-Based Molecular Tension Probes

[ACS Nano] To investigate the mechanical role of integrin in the geometrical interplay between cells and the ECM, researchers proposed a single-cell micropatterning technique combined with molecular tension fluorescence microscopy, which allowed for characterization of the mechanical properties of cells with prescribed geometries.

A TGFβ-ECM-Integrin Signaling Axis Drives Structural Reconfiguration of the Bile Duct to Promote Polycystic Liver Disease

[Science Translational Medicine] The development of cystic tissue required the activation of transforming growth factor–β (TGFβ) signaling, which promoted the expression of a procystic, fibronectin-rich ECM and which itself was perceived by a changing profile of integrin receptors on the cystic epithelium.

A Bioengineered Trachea-Like Structure Improves Survival in a Rabbit Tracheal Defect Model

[Science Translational Medicine] Investigators fabricated bioengineered cartilage rings from three-dimensionally printed fibers of poly(ɛ-caprolactone) and rabbit chondrocytes.

Lysyl Oxidase-Dependent Extracellular Matrix Crosslinking Modulates Calcification in Atherosclerosis and Aortic Valve Disease

[Biomedicine & Pharmacotherapy] Lysyl oxidase (LOX) conditions ECM biomechanical properties, and was upregulated in calcified valves from two cohorts of calcific aortic valve disease patients.

Bioinspired Multiphase Composite Gel Materials: From Controlled Micro-Phase Separation to Multiple Functionalities

[Chem] The critical design criteria and fabrication strategies of gel materials with micro-phase separation are summarized. Then, the multiple functionalities of these materials are systemically reviewed, including surface engineering, mechanical properties, shape memory, and sensor properties.

3D Chitosan Scaffolds Support Expansion of Human Neural Stem Cells in Chemically Defined Condition

[Matter] Researchers introduced chitosan scaffolds as an alternative culture platform to costly animal-sourced feeders, Matrigel, and Geltrex for human neural stem cell expansion.

Local BMP2 Hydrogel Therapy for Robust Bone Regeneration in a Porcine Model of Legg-Calvé-Perthes Disease

[NPJ Regenerative Medicine] Scientists developed a bone morphogenetic protein-2 (BMP2)-hydrogel treatment via a transphyseal bone wash and subsequential injection of BMP2-loaded hydrogel.

Activation of the Transcription Factor NFAT5 in the Tumor Microenvironment Enforces CD8+ T Cell Exhaustion

[Nature Immunology] Researchers found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8+ T cells in the context of chronic infections and tumors but was selectively required in tumor-induced CD8M+ T cell exhaustion.

Scientific Retractions May Become Easier to Spot As Retraction Watch Finds New Partner

[ScienceInsider] Retraction Watch, the influential website and database that tracks retractions in scholarly literature, is joining forces with another publishing nonprofit, Crossref, in hopes of helping researchers and journals flag articles that have been retracted and sustain the literature’s veracity.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.