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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
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Nitric Oxide Donor-Modified Extracellular Matrix Hydrogel Loaded with Salvianolic Acid B for Diabetic Wound Healing
[Journal of Materials Chemistry B] Scientists presented a skin-derived ECM–based platform that leverages its inherent biocompatibility and cell affinity for efficient nitric oxide delivery.
Extracellular Matrix Remodeling As an Immune-Regulatory Mechanism in Psoriasis: Implications for Tissue Persistence and Relapse
[Autoimmunity Reviews] This review evaluates whether ECM remodeling is merely a consequence of inflammation or can help maintain a relapse-permissive tissue state.
Decellularized CNS-Derived ECM Hydrogels As Dual-Action Scaffolds for Angiogenesis and Neurogenesis
[ACS Biomaterials Science & Engineering] Researchers developed bioactive scaffolds from decellularizedE ECM derived from four central nervous system (CNS) tissues: brain, spinal cord, spinal meninges, and optic nerve.
Targeting LOXL4-Driven Matrix Stiffening with Acetyldigoxin Restores CD8 T Cell Function in Lung Cancer
[Science Advances] Scientists investigated the role of lysyl oxidase–like 4 (LOXL4) in ECM stiffening and CD8+ T cell function in lung cancer. They established Loxl4 knockout and mouse recombinant LOXL4 protein systems, along with Piezo1, Ybx1, Acly, and Kat2a conditional knockout mouse models.
Cathepsin D As a Central Regulator of Extracellular Matrix Remodeling in Wound Healing and Chronic Tissue Pathologies
[Tissue Barriers] The authors synthesize mechanistic insights linking cathepsin D–mediated proteolysis to epithelial junction reorganization and permeability barrier recovery, and highlight emerging therapeutic strategies for improving chronic wound healing.
Mechanisms of Regeneration and Maladaptive Repair in Acute Kidney Injury
[Nature Reviews Nephrology] Aberrant tubular epithelial cells and immune-cell activation converges in the sustained activation of fibroblasts and the deposition of excess ECM via cellular crosstalk — the common final pathway of maladaptive repair — which drives the progression of acute kidney injury to chronic kidney disease over time.
NIR-Triggered Methylgermanane Nanosheet-Embedded Hydrogels Enable Cascade Dual-Organelle Stress to Potentiate Cancer Immunotherapy
[Advanced Healthcare Materials] Researchers developed an accelerated immunomodulatory matrix reservoir integrating methylgermanane nanosheets (mGeNS) within an active Ca2+-crosslinked alginate hydrogel. Upon near-infrared irradiation, localized hyperthermia softens the hydrogel, triggering the co-release of Ca2+ and an mGeNS-delivered immunogenic cell death inducer.
Party With a Purpose Honors the Power of Immunotherapy
[AACR] Party with a Purpose, an annual event support the American Association of Cancer Research (AACR), will recognize Dr. Robert Vonderheide, the Scientific Achievement Honoree, and Dr. Andrew Rech, who was nominated by Vonderheide, as the Early Career Investigator Honoree, for their continued efforts to drive new cancer immunotherapy advances.
The Tissue Engineering Grail: Seamless Biofabrication of Scaffold-Free Hollow Constructs
[Advanced Healthcare Materials] By expanding scaffold-free biofabrication beyond sheets and fibers to robust hollow geometries, researchers established a versatile set of physiologically relevant building blocks for scalable bottom-up assembly of complex, multi-tissue organ-like constructs within a bioassembloid framework.
Dual Functions of B7-H3-MAPK Signaling Orchestrate Tumor Immunosuppression via Regulating the Plasticity of Myeloid-Derived Suppressor Cells and Fibroblasts
[Cancer Discovery] Scientists reported that B7-H3 plays dual roles in regulating myeloid-derived suppressor cells and cancer-associated fibroblasts, thereby promoting tumor progression and therapy resistance, respectively.
SNED1 Modulates ECM Architecture and Cell Proliferation via Its LDV Integrin-Binding Motif Icon for the Forest of Biologists
[Journal of Cell Science] Researchers investigated the role of SNED1–integrin interactions in SNED1 ECM assembly. They found that the LDV motif, but not the RGE motif, in SNED1, was required for ECM build-up and the patterning of SNED1 and the fibrillar proteins fibronectin and collagen.
Frederick’s Stemora Secures $100,000 MIPS Matching Grant to Fund UMD Cartilage Research Collaboration
[Stemora, Inc. (BioBuzz)] Stemora, Inc. announced that it has received a $100,000 matching grant from the Maryland Industrial Partnerships program to fund a collaboration with Dr. Srinivasa Raghavan at the University of Maryland. The project will engineer controlled-release hydrogel formulations for STM-01.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
