Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Extracellular Matrix News
Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Subscribe|Follow Us On
European Commission Expands Role of Gilead’s Trodelvy® in First-Line Metastatic Triple-Negative Breast Cancer Across PD-L1 Status
[Gilead Sciences, Inc. (BioSpace)] Gilead Sciences, Inc. announced that the European Commission has granted marketing authorization for Trodelvy® in combination with Keytruday® for the treatment of adult patients with unresectable, locally advanced or metastatic triple-negative breast cancer (TNBC) who have not received prior systemic therapy for metastatic disease.
Matrix Stress Relaxation Drives Glioblastoma Cell Response in Viscoelastic Biomaterials
[Science Advances] Researchers engineered a tunable hyaluronan-elastin-like protein hydrogel to independently control ligand presentation and matrix viscoelasticity. Using dynamic covalent chemistry, they developed hydrogels with matched stiffness but distinct stress relaxation profiles.
Cancer-Associated Adipocytes: Metabolic Reprogramming, Crosstalk, and Therapeutic Implications in Tumor Progression
[Signal Transduction and Targeted Therapy] The authors synthesize how cancer-associated adipocytes and adipose dynamics drive oncogenesis, progression and therapeutic failure and highlight actionable nodes within the adipose–tumor axis for precision oncology.
CXCR4-Targeted Dual Softener for Inducing Senescence Therapy in Hepatic Fibrosis
[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed an activation of hepatic stellate cell-targeted nanocomplex to remodel a rigid fibrotic barrier. This platform inhibits the fibrotic process by inducing cellular senescence and activating endogenous immune surveillance.
Spatial Profiling of the Spleen in Mouse and Human Myelofibrosis Reveals Complement-Driven Immune-Stromal Interactions As a Therapeutic Target
[Cell Stem Cell] Scientists combined spatial and single-nucleus transcriptomics of patient spleens with spatial and single-cell transcriptomics, as well as imaging analyses, of murine spleens to map extramedullary hematopoiesis niches.
ST6GAL1-Mediated Sialyl Linkage Switching Drives Cancer-Promoting α2,6-Sialo-Protrusions Radiating from Anti-Inflammatory TAMs
[Proceedings of the National Academy of Sciences of the United States of America] Using system glycobiology approaches, the authors reported that ST6GAL1 facilitates profound sialyl linkage switching within the glycocalyx upon tumor-associated macrophage (TAM) polarization.
Unraveling the Epigenetic Code in Cancer Cell-Tumor Microenvironment Crosstalk
[Molecular Oncology] Scientists discussed various epigenetic mechanisms controlling cancer cell-intrinsic states, cancer cell–TME crosstalk, current epigenetic therapies, and future research directions that may lead to the discovery of new biomarkers and the development of effective epigenetic anticancer therapeutics.
Extracellular Matrix Composition and Stiffness Regulates Progesterone Responsiveness and Decidualization
[iScience] Investigators used hydrogels to mimic physiological stiffnesses and examine how mechanical and biochemical ECM cues influence progesterone-induced differentiation (decidualization) in healthy fibroblasts.
HydroMEA: A 3D Hydrogel-Based Microfluidic Device to Study Electrophysiology for Myelinated Nerve-on-Chip
[Advanced Healthcare Materials] Researchers described ‘hydroMEA,’ a 3D platform fabricated by placing polydimethylsiloxane microstructures on a high-density multielectrode array and filled with a desired hydrogel, to offer controlled topologies, physiologically relevant microenvironments, and real-time electrophysiological measurements.
UBC Medicine Researchers Awarded More Than $39 Million in CIHR Funding
Cell Therapy NewsDermal Cell NewsEndothelial Cell NewsESC & iPSC NewsExtracellular Matrix NewsHematopoiesis NewsMammary Cell NewsMuscle Cell NewsNeural Cell NewsNewslettersOrganoid NewsPancreatic Cell News
[The University of British Columbia] UBC Faculty of Medicine researchers have been awarded more than $39 million in federal funding through the Canadian Institutes of Health Research (CIHR) Project Grant: Spring 2026 competition.
A Thiol-Rich Immunomodulatory Injectable Hydrogel Suppresses Endometrial Fibrosis to Restore Fertilization
[Science Advances] Researchers reported a thiol-rich immunomodulatory injectable hydrogel (TR-gel) that forms in situ through Michael addition between acrylated hyaluronic acid and thiolated hyaluronic acid. In a rat intrauterine adhesion model, TR-gel decreased collagen deposition, promoted angiogenesis, and improved the fertility rate from 25.0 to 62.5%.
Damon Runyon Cancer Research Foundation Awards $4.2 Million to Exceptional Early-Career Scientists
[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 14 new Damon Runyon Fellows, brilliant postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
