Silencing of Sinusoidal DDR1 Reduces Murine Liver Metastasis by Colon Carcinoma

Liver metastasis depends on the collagenous microenvironment generated by hepatic sinusoidal cells (SCs). Hepatic DDR1 was found to promote C26 liver metastasis and favor the pro-metastatic response of SCs to the tumor.
[Scientific Reports]
Romayor, I., Badiola, I., Benedicto, A., Márquez, J., Herrero, A., Arteta, B., & Olaso, E. (2020). Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma. Scientific Reports, 10(1), 18398. https://doi.org/10.1038/s41598-020-75395-w Cite
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The Impact of Endotrophin on the Progression of Chronic Liver Disease

The fibrotic liver is characterized by the pathological accumulation of ECM proteins. Type VI collagen alpha3 is a biomarker of hepatic fibrosis, and its cleaved form, endotrophin (ETP), plays a critical role in adipose tissue dysfunction, insulin resistance, and breast cancer development. Scientists studied the effects of the Col6a3-derived peptide ETP on the progression of chronic liver diseases, such as NASH and liver cancer.
[Experimental and Molecular Medicine]
Kim, M., Lee, C., Seo, D. Y., Lee, H., Horton, J. D., Park, J., & Scherer, P. E. (2020). The impact of endotrophin on the progression of chronic liver disease. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-00520-8 Cite
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Osteogenic Potential of Human Adipose Derived Stem Cells (hASCs) Seeded on Titanium Trabecular Spinal Cages

This in vitro study evaluated the adhesion, proliferation and osteogenic differentiation of adipose derived MSCs (ASCs) seeded on trabecular titanium cages. ASCs adhered, proliferated and produced an abundant extracellular matrix during the 3 weeks of culture.
[Scientific Reports]
Caliogna, L., Bina, V., Botta, L., Benazzo, F. M., Medetti, M., Maestretti, G., Mosconi, M., Cofano, F., Tartara, F., & Gastaldi, G. (2020). Osteogenic potential of human adipose derived stem cells (hASCs) seeded on titanium trabecular spinal cages. Scientific Reports, 10(1), 18284. https://doi.org/10.1038/s41598-020-75385-y Cite
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Emerging Players in Prostate Cancer–Bone Niche Communication

The authors highlight the emerging role of prostate cancer (PCa)-derived extracellular vesicles in reprogramming osteoblasts and support of premetastatic niche formation. They also develop the concept of cancer-associated osteoblasts and outline the potential of PCa cells to acquire an osteoblastic phenotype, termed osteomimicry, as two strategies that PCa utilizes to create a favorable protected niche.
[Trends in Cancer]
Furesi, G., Rauner, M., & Hofbauer, L. C. (2020). Emerging Players in Prostate Cancer–Bone Niche Communication. Trends in Cancer, 0(0). https://doi.org/10.1016/j.trecan.2020.09.006 Cite
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FRESH 3D Bioprinting a Full-Size Model of the Human Heart

The advantage of approaches such as Freeform Reversible Embedding of Suspended Hydrogels (FRESH) printing is the ability to embed soft biomaterials in a thermoreversible support bath at sizes ranging from a few millimeters to centimeters. In this study, researchers were able to expand this printable size range by FRESH bioprinting a full-size model of an adult human heart from patient-derived magnetic resonance imaging data sets.
[ACS Biomaterials Science & Engineering]
Mirdamadi, E., Tashman, J. W., Shiwarski, D. J., Palchesko, R. N., & Feinberg, A. W. (2020). FRESH 3D Bioprinting a Full-Size Model of the Human Heart. ACS Biomaterials Science & Engineering. https://doi.org/10.1021/acsbiomaterials.0c01133 Cite
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Needle-Injectable Microcomposite Cryogel Scaffolds With Antimicrobial Properties

Researchers indicated that needle-injectable and biodegradable calcium peroxide-containing cryogels exhibited antimicrobial activity that holds great promise for a wide variety of biomedical applications, particularly when designing tissue engineering scaffolds.
[Scientific Reports]
Joshi Navare, K., Colombani, T., Rezaeeyazdi, M., Bassous, N., Rana, D., Webster, T., Memic, A., & Bencherif, S. A. (2020). Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties. Scientific Reports, 10(1), 18370. https://doi.org/10.1038/s41598-020-75196-1 Cite
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Mesoscopic 3D Imaging of Pancreatic Cancer and Langerhans Islets Based on Tissue Autofluorescence

The authors demonstrated a method that without prior immunohistochemical labelling provides insight into the 3D microenvironment and spread of PDAC and premalignant cysts in intact surgical biopsies.
[Scientific Reports]
Hahn, M., Nord, C., Franklin, O., Alanentalo, T., Mettävainio, M. I., Morini, F., Eriksson, M., Korsgren, O., Sund, M., & Ahlgren, U. (2020). Mesoscopic 3D imaging of pancreatic cancer and Langerhans islets based on tissue autofluorescence. Scientific Reports, 10(1), 18246. https://doi.org/10.1038/s41598-020-74616-6 Cite
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Escherichia coli Foster Bladder Cancer Cell Line Progression via Epithelial Mesenchymal Transition, Stemness and Metabolic Reprogramming

In vitro infection of the T24 cell line with E. coli was performed to study the bacterial impact on bladder cancer cells. EMT markers were assessed using immunohistochemistry, western blot and RT-PCR. Stemness characteristics were monitored using RT-PCR.
[Scientific Reports]
Abd-El-Raouf, R., Ouf, S. A., Gabr, M. M., Zakaria, M. M., El-Yasergy, K. F., & Ali-El-Dein, B. (2020). Escherichia coli foster bladder cancer cell line progression via epithelial mesenchymal transition, stemness and metabolic reprogramming. Scientific Reports, 10(1), 18024. https://doi.org/10.1038/s41598-020-74390-5 Cite
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Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer

To what extent stromal cells in the tumor microenvironment (TME) are transformed by colorectal cancer (CRC) cells is unexplored. Researchers performed single-cell multiomics sequencing of 21 patients with microsatellite-stable CRCs and six cancer-free, elderly individuals.
[Cancer Cell]
Zhou, Y., Bian, S., Zhou, X., Cui, Y., Wang, W., Wen, L., Guo, L., Fu, W., & Tang, F. (2020). Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.09.015 Cite
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Lung Gene Expression Signatures Suggest Pathogenic Links and Molecular Markers for Pulmonary Tuberculosis, Adenocarcinoma and Sarcoidosis

The authors revealed a distinct ossification-related tuberculosis (TB) lung signature, which may be associated with the activation of the BMP/SMAD/RUNX2 pathway in Mtb-infected macrophages that can restrain mycobacterial survival and promote osteogenic differentiation of mesenchymal stem cells.
[Communications Biology]
Chai, Q., Lu, Z., Liu, Z., Zhong, Y., Zhang, F., Qiu, C., Li, B., Wang, J., Zhang, L., Pang, Y., & Liu, C. H. (2020). Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis. Communications Biology, 3(1), 1–17. https://doi.org/10.1038/s42003-020-01318-0 Cite
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Extracellular Matrix Plasticity as a Driver of Cell Spreading

Scientists demonstrated that network plasticity independently controls mesenchymal stem cell spreading through a biphasic relationship dependent on cell-intrinsic forces, and this relationship can be shifted by inhibiting actomyosin contractility.
[Proceedings of the National Academy of Sciences of the United States of America]
Grolman, J. M., Weinand, P., & Mooney, D. J. (2020). Extracellular matrix plasticity as a driver of cell spreading. Proceedings of the National Academy of Sciences, 117(42), 25999–26007. https://doi.org/10.1073/pnas.2008801117 Cite
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