Extracellular Matrix News
Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
iVeena Secures $3 Million in Series B-2 Financing to Accelerate Development of IVMED-85 for Myopia
[iVeena Delivery Systems, Inc (iVeena) (BusinessWire)] iVeena, a company advancing IVMED-85 for the treatment of pediatric myopia, announced that it has closed its subscribed Series B-2 financing of $3 million. IVMED-85 is a daily eye drop that strengthens scleral and corneal collagen crosslinks through LOX activation.
Live Imaging of the Extracellular Matrix with a Glycan-Binding Fluorophore
[Nature Methods] Scientists presented a cell-impermeable small-molecule fluorophore, termed Rhobo6, that turned on and red shifts upon reversible binding to glycans.
Pyxis Oncology Initiates New PYX-201 Combination Trial and Initiates Cohort Expansions of Ongoing Monotherapy Trial
[Pyxis Oncology, Inc.] Pyxis Oncology, Inc. announced progress in its clinical program for PYX-201, a first-in-concept antibody-drug conjugate that targets extradomain-b fibronectin, a non-cellular structural component within the tumor ECM, which is highly expressed in various tumor types.
RUNX2 Promotes Fibrosis via an Alveolar-to-Pathological Fibroblast Transition
[Nature] Scientists used two mouse models of pulmonary fibrosis to show that LEPR+ fibroblasts that arise during alveologenesis included SCUBE2+ alveolar fibroblasts as a major constituent. These alveolar fibroblasts in turn contributed to pathological fibroblasts.
Biomimetic Basement Membrane: Advances in Materials, Fabrication Techniques, and Applications in In Vitro Biological Models
[Biomaterials Science] The authors explore the materials, preparation techniques, and applications of biomimetic basement membrane across various biological models, highlighting their advantages and limitations. They identify current challenges in achieving BM simulations that mimic native structures.
Micro Immune Response On-Chip (MIRO) Models the Tumor-Stroma Interface for Immunotherapy Testing
[Nature Communications] Researchers developed MIRO, a fully humanized in vitro platform to model the spatial organisation of the tumor/stroma interface and its interaction with immune cells. In MIRO, cell co-culture was optimized in 2.5D to generate a well-defined cancer/stroma interface.
A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity
[Cancer Research] Researchers developed a hydrogel-free self-assembly platform to establish ECM-rich 3D “MatriSpheres” to deconvolute cancer cell-ECM interactions. MatriSpheres featured ECM-dependent transcriptional and cytokine profiles associated with malignancy, lipid metabolism, and immunoregulation.
Extracellular Matrix Stiffness Regulates Colorectal Cancer Progression via HSF4
[Journal of Experimental & Clinical Cancer Research] A heat shock transcriptional factor 4 (HSF4) knockout colorectal cancer cell model was cultured in different ECM stiffness to evaluate the effects of HSF4 on cell proliferation, migration, and invasion in vitro and in vivo.
Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation
[Advanced Science] Researchers prepared humanized corneal stroma-like adhesive patches (HCSPs) through a multi-step process. In rabbit models of lamellar keratoplasty and microperforation repair, HCSPs accelerated epithelial healing, minimized suture-associated complications, and maintained structural stability.
A Safe Haven for Cancer Cells: Tumor Plus Stroma Control by DYRK1B
[Oncogene] Recent evidence suggests that dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) exerts its oncogenic features by installing a protective niche for cancer cells by directly affecting cancer cells but also the TME.
Programmed Shape Transformations in Cell-Laden Granular Composites
[Science Advances] The authors used combinations of mesenchymal stromal cell spheroids and hydrogel microparticles with varied hydrolytic stability to fabricate programmable and dynamic granular composites that controlled compaction and tissue formation over time.
Masquelet Inspired in Vivo Engineered Extracellular Matrix as Functional Periosteum for Bone Defect Repair and Reconstruction
[Advanced Healthcare Materials] Inspired by Masquelet's technique, here a novel approach was devised to create periosteum mimetics from decellularized ECM, engineered in vivo through foreign body reaction, for reconstruction of segmental bone defects.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.