Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Strategy of a Cell-Derived Extracellular Matrix for the Construction of an Osteochondral Interlayer

[Biomaterials Science] Scientists proposed that an ECM-derived from a suitable cell source might efficiently promote the formation of calcified cartilage.

IL-10-Functionalized Hydrogels Support Immunosuppressive Dendritic Cell Phenotype and Function

[ACS Biomaterials Science & Engineering] The authors developed a 4-arm poly(ethylene-glycol)-maleimide hydrogel functionalized with interleukin-10 to improve the local delivery and efficacy of a cell therapy against autoimmune disease.

Selenium-Sensitive Histone Deacetylase 2 Is Required for Forkhead Box O3A and Regulates Extracellular Matrix Metabolism in Cartilage

[Journal of Bone and Mineral Metabolism] Scientists explored the relationship between differentially expressed histone deacetylases and cartilage development, especially ECM homeostasis maintenance.

Adipose Extracellular Matrix Deposition Is an Indicator of Obesity and Metabolic Disorders

[Journal of Nutritional Biochemistry] Multiple collagens, laminins, fibronectin, nidogen, and Hspg2 were upregulated in obese white adipose tissue from mice and humans.

Role of MMP3 and Fibroblast-MMP14 in Skin Homeostasis and Repair

[European Journal of Cell Biology] To identify the compensatory role of matrix metalloproteinase 3 (MMP3), mice were generated with MMP3 deletion in addition to MMP14 loss in fibroblasts.

Biomaterials and Tissue Engineering Approaches Using Glycosaminoglycans for Tissue Repair: Lessons Learned from the Native Extracellular Matrix

[Acta Biomaterialia] Scientists provide an overview of native glycosaminoglycans, their structure, and properties, specifically their interaction with proteins, their effect on cell behavior, and their mechanical role in the ECM.

Matrix-Directed Mineralization for Bulk Structural Materials

[Journal of the American Chemical Society] The authors provide a panoramic view of an emerging fabrication strategy, matrix-directed mineralization, which imitates the in vivo growth of some biominerals.

MIT Biologist Richard Hynes Wins Lasker Award

[Massachusetts Institute of Technology] MIT Professor Richard Hynes, a pioneer in studying cellular adhesion, has been named a recipient of the 2022 Albert Lasker Basic Medical Research Award.

Organization, Dynamics and Mechanoregulation of Integrin-Mediated Cell–ECM Adhesions

[Nature Reviews Molecular Cell Biology] Investigators review how the interplay of mechanical forces, biochemical signalling and molecular self-organization determines the composition, organization, mechanosensitivity and dynamics of these adhesions.

Activated Natural Killer Cells-Dependent Dendritic Cells Recruitment and Maturation by Responsive Nanogels for Targeting Pancreatic Cancer Immunotherapy

[Small] Researchers used tumor microenvironment responsive nanogels with prominent tumor-targeting capability by Panc02 cell membranes coating and inhibition of tumor-derived prostaglandin E2, aimed at improving natural killer cells activation, and inducing activated NK cells-dependent dendritic cells recruitment.

AlphaFold Developers Win US$3-Million Breakthrough Prize

[Nature News] Demis Hassabis and John Jumper, both at DeepMind in London, were recognized for creating the tool that has predicted the 3D structures of almost every known protein on the planet.

Exploring the Difference in the Mechanics of Vascular Smooth Muscle Cells from Wild Type and Apolipoprotein-E Knockout Mice

[American Journal of Physiology-Cell Physiology] Using an atherosclerotic murine model, scientists analyzed how the mechanics of vascular smooth muscle cells isolated from western diet fed apolipoprotein-E knockout and wild-type mice were altered during atherosclerosis.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.