Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

An mTurq2-Col4a1 Mouse Model Allows for Live Visualization of Mammalian Basement Membrane Development

[Journal Of Cell Biology] Using an innovative planar-sagittal live imaging technique to visualize the basement membrane of developing skin, researchers directly observed basement membrane deformation during hair follicle budding and basal progenitor cell divisions.

Piezo1-Mediated Regulation of Smooth Muscle Cell Volume in Response to Enhanced Extracellular Matrix Rigidity

[British Journal of Pharmacology] Human aortic-vascular smooth muscle cells were seeded onto polyacrylamide hydrogels whose rigidity mimicked either healthy or aged/diseased aortae.

Intracellular Tension Sensor Reveals Mechanical Anisotropy of the Actin Cytoskeleton

[Nature Communications] Researchers developed a molecular tension sensor that embeds into the F-actin cytoskeleton. Using this sensor, they measured tension within stress fibers and cortical actin, as the cell was subject to uniaxial stretch.

Delayed Collagen Production Without Myofibroblast Formation Contributes to Reduced Scarring in Adult Skin Micro-Wounds

[Journal Of Investigative Dermatology] The study delineated the cellular attributes of microthermal zones, underscoring a temporally limited, subclinical inflammatory milieu concomitant with rapid re-epithelialization within 24 hours.

Electrospun Poly(carbonate-urea-urethane)s Nonwovens with Shape-Memory Properties as a Potential Biomaterial

[ACS Biomaterials Science & Engineering] Scientists investigated the suitability of Poly(carbonate-urea-urethane) as polymers for the manufacturing of nonwoven mats by electrospinning, able to closely mimic the fibrous structure of the extracellular matrix.

Tanshinone IIA Ameliorates the Development of Dermal Fibrosis in Systemic Sclerosis

[Clinical And Experimental Pharmacology And Physiology] Researchers determined whether tanshinone IIA could directly act on the skin fibroblasts of scleroderma and look into its underlying anti-fibrotic mechanisms.

The C-type Lectin COLEC10 Is Predominantly Produced by Hepatic Stellate Cells and Involved in the Pathogenesis of Liver Fibrosis

[Cell Death & Disease] Investigators found the C-type lectins including Colec10 and Colec11 were not produced by hepatocytes but predominantly produced by hepatic stellate cells, especially quiescent ones in the mice livers. In vitro overexpression of COLEC10 in LX-2 cells promotes the mRNA expression of extracellular matrix components including COL1A1, COL1A2 and COL3A1 and the extracellular matrix degradation enzyme MMP2.

Preventive Effects of Ramelteon on Bleomycin-Induced Pulmonary Fibrosis in Mice

[Naunyn-Schmiedebergs Archives Of Pharmacology] Ramelteon partially abrogated TGF-β1-induced pulmonary fibrosis and reduced fibroblast proliferation, extracellular matrix deposition, and differentiation into myofibroblasts. In vivo experiments, ramelteon attenuated bleomycin-induced pulmonary fibrosis and collagen deposition.

hsdSA Regulated Extracellular Vesicle-Associated PLY to Protect Streptococcus pneumoniae from Macrophage Killing via LAPosomes

[Microbiology Spectrum] hsdSA regulated the production of extracellular vesicles which package cytosolic, surface, and secreted proteins, including pneumolysin.

The Antioxidant Glycitin Protects Against Intervertebral Disc Degeneration Through Antagonizing Inflammation and Oxidative Stress in Nucleus Pulposus Cells

[Aging] Researchers found that Glycitin alleviated TNF-α-induced metabolic disorders, extracellular matrix degradation, oxidative stress, inflammation responses, and mitochondrial damage.

Anika Announces First Surgeries Performed using the Integrity™ Implant System, a Regenerative Hyaluronic Acid-Based Patch System for Rotator Cuff Repairs, Commencing Limited Market Release

[Anika Therapeutics, Inc. (Globe Newswire)] Anika Therapeutics, Inc. announced that the first surgeries using the Integrity Implant System. Integrity is designed to protect an injured tendon and promote healing in rotator cuff repair and other tendon procedures using hyaluronic acid-based scaffold with bone and tendon fixation components.

Mouse Gingival Single-Cell Transcriptomic Atlas Identified a Novel Fibroblast Subpopulation Activated to Guide Oral Barrier Immunity in Periodontitis

[eLife] Scientists reported a unique fibroblast subpopulation activated to guide oral inflammation identified in a single-cell RNA sequencing gingival cell atlas constructed from the mouse periodontitis models.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.