Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

3D Printed Multi-Growth Factor Delivery Patches Fabricated Using Dual-Crosslinked Decellularized Extracellular Matrix-Based Hybrid Inks to Promote Cerebral Angiogenesis

[Acta Biomaterialia] Scientists developed a 3D printed spatiotemporally compartmentalized cerebral angiogenesis inducing hydrogel patch, releasing dual angiogenic growth factors, using extracellular matrix-based hybrid inks.

Extracellular Matrix Sheet Modified with VEGF-Loaded Nanoparticles for Bladder Regeneration

[NPG Asia Materials] ECM bioscaffolds were derived from decellularized sheets and then modified with vascular endothelial growth factor (VEGF)-conjugated superparamagnetic iron oxide nanoparticles to promote angiogenesis.

Micromechanical Property Mismatch between Pericellular and Extracellular Matrices Regulates Stem Cell Articular and Hypertrophic Chondrogenesis

[Matter] Researchers reported a unique biomaterial-based engineering strategy to create cartilage-tissue equivalents possessing pericellular matrix (PCM)-ECM microarchitecture of native cartilage, where human mesenchymal stem cell-laden soft microgels representing PCM were encapsulated in stiff hydrogels representing ECM.

Bone ECM-Like 3D Printing Scaffold with Liquid Crystalline and Viscoelastic Microenvironment for Bone Regeneration

[ACS Nano] Investigators developed a facile approach to fabricate a bionic scaffold perfectly combining bone ECM-like microenvironment and robust mechanical properties.

Cross-Talk between TSC2 and the Extracellular Matrix Controls Pulmonary Vascular Proliferation and Pulmonary Hypertension

[Science Signaling] ECM produced by tuberous sclerosis complex 2 (TSC2)-deficient pulmonary artery vascular smooth muscle cells (PAVSMCs) stimulated the proliferation of nondiseased PA adventitial fibroblasts and PAVSMCs through fibronectin and its receptor.

Matrix Metalloproteinase 1 as a Marker of Tonsil-Derived Mesenchymal Stem Cells to Assess Bone Marrow Cell Migration

[Tissue Engineering and Regenerative Medicine] To examine the donor-to-donor variation of tonsil-derived mesenchymal stem cells (TMSCs) in potentiating bone marrow cells migration, the authors isolated TMSCs from 25 independent donors.

Amyloid-Based Albumin Hydrogels

[Advanced Healthcare Materials] Scientists presented the formation of physically cross-linked, self-healing hydrogels based on bovine serum albumin at room temperature through a straightforward disulfide reduction step induced by tris (2-carboxyethyl) phosphine hydrochloride.

Advances in Biomimetic Collagen Mineralisation and Future Approaches to Bone Tissue Engineering

[Biopolymers] Scientists sum up the current understanding of bone tissue mineralisation and structure while providing a critical outlook on the existing biomimetic strategies of mineralising collagen for bone tissue engineering applications, highlighting where gaps in knowledge exist.

Laminin Matrix Adhesion Regulates Basal Mammary Epithelial Cell Identity

[Journal of Cell Science] Researchers showed that adhesion of basal cells to laminin α5-containing basement membrane matrix, which was produced by luminal cells, presented a regulated control mechanism to restrict excess basal cell activity.

Heterogeneous Matrix Stiffness Regulates the Cancer Stem-Like Cell Phenotype in Hepatocellular Carcinoma

[Journal of Translational Medicine] Investigators provided new insights into the interaction between matrix stiffness, cancer cell stemness, and heterogeneity, while also providing a novel hepatocellular carcinoma therapeutic strategy.

Extracellular Matrix Profiles Determine Risk and Prognosis of the Squamous Cell Carcinoma Subtype of Non-Small Cell Lung Carcinoma

[Genome Medicine] Scientists revealed subtype-specific ECM signatures associated with tumor initiation that were predictive of premalignant progression.

Extracellular Matrix Drives Tumor Organoids toward Desmoplastic Matrix Deposition and Mesenchymal Transition

[Acta Biomaterialia] The authors combined cholangiocarcinoma organoids with native tumor and liver scaffolds, obtained by decellularization, to effectuate a model to study the interaction between epithelial tumor cells and their surrounding ECM.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.