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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Imbed Biosciences Announces FDA IDE Approval for Silver-Gallium Synthetic Antimicrobial Matrix Clinical Study with Human Donor Site Wounds
[Imbed Biosciences (BioSpace)] Imbed Biosciences announced the US FDA has approved an Investigational Device Exemption application to conduct a feasibility clinical trial to validate the safety of their pipeline polymeric matrix with silver and gallium ions in human donor site wounds.
Cellino and Matricelf Announce Global Collaboration to Scale Personalized Spinal Cord Injury Treatments
[Cellino (BioSpace)] Cellino and Matricelf announced a collaboration to accelerate the global biomanufacturing of personalized spinal cord injury treatments using Cellino’s Nebula™ technology combined with Matricelf’s breakthrough regenerative approach.
Matrix-Producing Neutrophils Populate and Shield the Skin
[Nature] Scientists examined immune diversity across tissues and identified a population of neutrophils in the skin that expressed a broad repertoire of proteins and enzymes needed to build the ECM.
Cell-Matrix Feedback Controls Stretch-Induced Cellular Memory and Fibroblast Activation
[Proceedings of The National Academy of Sciences of The United States of America] Researchers showed that static mechanical stretch of cells in 3D tissues could either increase or decrease fibroblast activation depending upon recursive cell–ECM feedback and demonstrated control of this activation through integrated in vitro and mathematical models.
Epigenetic Drivers of Metalloproteinases and Metastasis
[Trends in Cell Biology] Aberrant metalloproteinases (MP) expression can result in pathological events, involving ECM remodeling, which can facilitate cancer cell invasion and dissemination. Targeting the epigenetic regulators of MP expression may be an alternative approach for the prevention and treatment of metastatic disease.
Fibrosis: Cross-Organ Biology and Pathways to Development of Innovative Drugs
[Nature Reviews Drug Discovery] Scientists integrate viewpoints of biologists and physician-scientists on core pathways involved in fibrosis across organs, as well as on specific characteristics and approaches to assess therapeutic interventions for fibrotic diseases of the lung, gut, kidney, skin and liver.
Title Actuated Hydrogel Platforms To Study Brain Cell Behavior
[Advanced Healthcare Materials] The authors discuss current hydrogel platforms used to investigate brain function in health and disease, focusing on traumatic brain injury-like conditions and brain tumors.
The Fibroinflammatory Response in Cancer
[Nature Reviews Cancer] The authors review advances made in unravelling the complexity of cancer-associated fibroinflammation that can inform the rational design of therapies targeting this.
Anti-Inflammatory and Antibacterial Hydrogel Based on a Polymerizable Ionic Liquid
[Acta Biomaterialia] Scientists proposed a dual-action hydrogel composed of methacrylated gelatin as a matrix and a salicylate anion-exchanged polymerizable ionic liquid to achieve anti-inflammatory and antibacterial activities.
ER O-Glycosylation in Synovial Fibroblasts Drives Cartilage Degradation
[Nature Communications] Researchers showed that lining synovial fibroblasts from arthritic patients but not from healthy individuals display marked ER relocation of polypeptide N-acetylgalactosaminyltransferases. The resulting increase of O-glycosylation, driven by re-compartmentation of the enzymes, was critical for disease progression in mice.
Y Chromosome-Linked UTY Modulates Sex Differences in Valvular Fibroblast Methylation in Response to Nanoscale Extracellular Matrix Cues
[Science Advances] Scientists hypothesized that the lysine demethylase ubiquitously transcribed tetratricopeptide repeat containing Y-linked (UTY) decreased methylation uniquely in male valvular interstitial cells responding to nanoscale ECM cues to promote an osteoblast-like cell phenotype.
Piezo-Dependent Surveillance of Matrix Stiffness Generates Transient Cells That Repair the Basement Membrane
[Developmental Cell] Using the intestinal basement membrane of adult Drosophila as a model, the authors showed that after basement membrane damage, there was a sharp increase in enteroblasts transiently expressing Col4, termed “matrix mender” cells.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
