Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Atypical Cofilin Signaling Drives Dendritic Cell Migration through the Extracellular Matrix via Nuclear Deformation

[Cell Reports] Scientists showed that inflammatory activation of dendritic cells leads to the nucleus becoming spherically deformed and enables dendritic cells to overcome the typical 2- to 3-μm diameter limit for 3D migration through gaps in the ECM.

ETS Transcription Factors Regulate Precise Matrix Metalloproteinase Expression and Follicle Rupture in Drosophila

[Development] The authors demonstrated crucial roles for the ETS-family transcriptional activator Pointed and its endogenous repressor Yan in the regulation of MMP2 expression.

Endothelial Cells Regulate Alveolar Morphogenesis by Constructing Basement Membranes Acting as a Scaffold for Myofibroblasts

[Nature Communications] Investigators showed that endothelial cells regulated alveologenesis by constructing basement membranes acting as a scaffold for myofibroblasts to induce septa formation through activating mechanical signaling.

Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix

[ACS Nano] Investigators focus on the regulatory role of nanomaterials in the process of cell synthesis of different ECM-related proteins and extracellular protease.

Three Dimensional Fibrotic Extracellular Matrix Directs Microenvironment Fiber Remodeling by Fibroblasts

[Acta Biomaterialia] Investigators compared how control and idiopathic pulmonary fibrosis lung-derived fibroblasts responded in control and fibrotic microenvironments in a combinatorial manner. Culture of fibroblasts in fibrotic hydrogels did not alter in the overall amount of collagen or glycosaminoglycans but did cause a drastic change in fiber organization compared to culture in control hydrogels.

Myofibroblasts Reside in the Middle Dermis of the Keloids but Do Not Predict the Response to Injection Therapies: A Double-Blinded, Randomized, Controlled Trial

[Frontiers In Medicine] The authors carried out a double-blinded randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil and triamcinolone injections in treating keloids. A total of 43 patients with 50 keloids were treated with either intralesional triamcinolone or 5-FU injections, and their clinical response was evaluated.

Elevated Extracellular Matrix Protein 1 in Circulating Extracellular Vesicles Supports Breast Cancer Progression Under Obesity Conditions

[Nature Communications] Researchers showed that in obesity, ECM protein 1 (ECM1) protein levels were significantly increased in circulating small extracellular vesicles, which is dependent on integrin-β2.

PolyGR and polyPR Knock-In Mice Reveal a Conserved Neuroprotective Extracellular Matrix Signature in C9orf72 ALS/FTD Neurons

[Nature Neuroscience] Investigators generated C9orf72 dipeptide repeat knock-in mouse models characterized by the expression of 400 codon-optimized polyGR or polyPR repeats, and heterozygous C9orf72 reduction.

FGF18 Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting the NF-κB Pathway

[Respiratory Research] A mouse model of acute lung injury and HUVEC stimulated with lipopolysaccharide was established in vivo and in vitro. AAV-FGF18 and fibroblast growth factor 18 (FGF18) proteins were used in C57BL/6J mice and HUVEC, respectively.

Mineralized Collagen Scaffolds for Regenerative Engineering Applications

[Current Opinion In Biotechnology] Scientists summarize key considerations regarding the current state-of-the-art design and use of collagen biomaterials for tissue engineering applications.

Early Pulmonary Fibrosis Detection Holds the Key to Better Health Outcomes for Canadians Living with COVID-19 and Rheumatoid Arthritis

[The Whig] Canadians who have had COVID-19, and other chronic diseases, are experiencing pulmonary fibrosis at significantly higher rates than others, seemingly providing a causal link that researchers are investigating.

Oleic Acid-PPARγ-FABP4 Loop Fuels Cholangiocarcinoma Colonization in Lymph Node Metastases Microenvironment

[Hepatology] Scientists determined whether metabolic reprogramming fueled the adaptation and remodeling of cholangiocarcinoma cells to the lymph node microenvironment.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.