Pancreatic Ductal Adenocarcinoma Progression Is Restrained by Stromal Matrix

Experimentally manipulating stromal matrix with an anti– lysyl oxidase like-2 antibody in syngeneic orthotopic pancreatic ductal adenocarcinoma mouse models significantly decreased matrix content, led to lower tissue stiffness, lower contrast retention on computed tomography, and accelerated tumor growth, resulting in diminished overall survival.
[Journal of Clinical Investigation]
Jiang, H., Torphy, R. J., Steiger, K., Hongo, H., Ritchie, A. J., Kriegsmann, M., Horst, D., Umetsu, S. E., Joseph, N. M., McGregor, K., Pishvaian, M. J., Blais, E. M., Lu, B., Li, M., Hollingsworth, M., Stashko, C., Volmar, K., Yeh, J. J., Weaver, V. M., … Collisson, E. A. (2020). Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix. The Journal of Clinical Investigation, 130(9). https://doi.org/10.1172/JCI136760 Cite
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Amyloid Aggregates Accumulate in Melanoma Metastasis Modulating YAP Activity

Using secretome analyses, the authors revealed the extracellular accumulation of amyloidogenic proteins, i.e. premelanosome protein, in metastatic melanoma, together with proteins that assist amyloid maturation into fibrils.
[EMBO Reports]
Matafora, V., Farris, F., Restuccia, U., Tamburri, S., Martano, G., Bernardelli, C., Sofia, A., Pisati, F., Casagrande, F., Lazzari, L., Marsoni, S., Bonoldi, E., & Bachi, A. (2020). Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity. EMBO Reports, n/a(n/a), e50446. https://doi.org/10.15252/embr.202050446 Cite
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Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis

The authors aims to understand the biological processes, key events, and consequences regarding the hypoxia-driven metabolic adaptation of tumor cells.
[International Journal of Molecular Sciences]
Miranda-Galvis, M., & Teng, Y. (2020). Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis. International Journal of Molecular Sciences, 21(15), 5487. https://doi.org/10.3390/ijms21155487 Cite
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Researchers examined how regulation and function of gene products that provide the target epitopes for CD8+ T cell anti-tumor immunity influence therapeutic efficacy and resistance.
[Immunity]
Effern, M., Glodde, N., Braun, M., Liebing, J., Boll, H. N., Yong, M., Bawden, E., Hinze, D., Boorn-Konijnenberg, D. van den, Daoud, M., Aymans, P., Landsberg, J., Smyth, M. J., Flatz, L., Tüting, T., Bald, T., Gebhardt, T., & Hölzel, M. (2020). Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.07.007 Cite
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The Mesenchymal Context in Inflammation, Immunity and Cancer

Investigators provide a concise overview of the contextual contribution of fibroblastic mesenchymal cells in physiology and disease and bring into focus emerging evidence for both their heterogeneity at the single-cell level and their tissue-specific, spatiotemporal functional diversity.
[Nature Immunology]
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Correlative Study of Epigenetic Regulation of Tumor Microenvironment in Spindle Cell Melanomas and Cutaneous Malignant Peripheral Nerve Sheath Tumors

Scientists investigated the epigenetic regulation of promoters and gene bodies and their effect on the tumor microenvironment composition of cutaneous malignant peripheral nerve sheath tumors and spindle cell melanomas.
[Scientific Reports]
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Fabrication of Homotypic Neural Ribbons as a Multiplex Platform Optimized for Spinal Cord Delivery

Neural ribbons offer multifunctionality in vitro including co-encapsulation of the injury site ESM modifier chondroitinase ABC, tested in glial scar models, and ability of cervically-patterned spinal cord neural stem cells to differentiate within neural ribbons and project axons for integration with 3D external matrices.
[Scientific Reports]
Olmsted, Z. T., Stigliano, C., Badri, A., Zhang, F., Williams, A., Koffas, M. A. G., Xie, Y., Linhardt, R. J., Cibelli, J., Horner, P. J., & Paluh, J. L. (2020). Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery. Scientific Reports, 10(1), 12939. https://doi.org/10.1038/s41598-020-69274-7 Cite
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An In-Silico Study of Cancer Cell Survival and Spatial Distribution within a 3D Microenvironment

Scientists present SALSA (ScAffoLd SimulAtor), a general purpose computational tool that can simulate the behavior of a population of cells cultured in a 3D scaffold.
[Scientific Reports]
Cortesi, M., Liverani, C., Mercatali, L., Ibrahim, T., & Giordano, E. (2020). An in-silico study of cancer cell survival and spatial distribution within a 3D microenvironment. Scientific Reports, 10(1), 12976. https://doi.org/10.1038/s41598-020-69862-7 Cite
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Cleavage of Proteoglycans, Plasma Proteins and the Platelet-Derived Growth Factor Receptor in the Hemorrhagic Process Induced by Snake Venom Metalloproteinases

The authors outlined the multifactorial character of snake venom metalloproteinases (SVMP)-induced tissue damage, including the transient activation of tissue proteinases, and underscore for the first time that endothelial glycocalyx proteoglycans and PDGFR are targets of SVMPs in the disruption of microvasculature integrity and generation of hemorrhage.
[Scientific Reports]
Asega, A. F., Menezes, M. C., Trevisan-Silva, D., Cajado-Carvalho, D., Bertholim, L., Oliveira, A. K., Zelanis, A., & Serrano, S. M. T. (2020). Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. Scientific Reports, 10(1), 12912. https://doi.org/10.1038/s41598-020-69396-y Cite
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Temperature-Regulated Heterogeneous Extracellular Matrix Gene Expression Defines Biofilm Morphology in Clostridium Perfringens

Researchers find that the temperature-regulated production of extracellular polymeric substance is necessary for morphological changes in biofilms.
[NPJ Biofilms and Microbiomes]
Obana, N., Nakamura, K., & Nomura, N. (2020). Temperature-regulated heterogeneous extracellular matrix gene expression defines biofilm morphology in Clostridium perfringens. Npj Biofilms and Microbiomes, 6(1), 1–11. https://doi.org/10.1038/s41522-020-00139-7 Cite
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Engineering CAR-T Cells for Next-Generation Cancer Therapy

Investigators highlight recent strategies to improve chimeric antigen therapy (CAR)-T cell therapy by engineering the CAR protein, T cells, and the interaction between T cells and other components in the tumor microenvironment.
[Cancer Cell]
Hong, M., Clubb, J. D., & Chen, Y. Y. (2020). Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.07.005 Cite
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