Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

BioRestorative Therapies Announces Clinical Trial Contract with Second Site for the Company’s Phase II Clinical Trial to Treat Chronic Lumbar Disc Disease (cLDD)

[BioRestorative Therapies, Inc.] BioRestorative Therapies, Inc. announced it has reached an agreement with its second clinical site for its Phase II clinical trial targeting chronic lumbar disc disease.

Extracellular Microenvironmental Control for Organoid Assembly

[Tissue Engineering Part B-Reviews] Investigators summarize the natural tissue and organ's unique chemical and mechanical properties, guiding researchers to design an extracellular microenvironment used for organoid engineering

3D Culture Modeling of Metastatic Breast Cancer Cells in Additive Manufactured Scaffolds

[ACS Applied Materials & interfaces] Scientists used porous 3D scaffolds, designed with two different porosities along with 2D tissue culture polystyrene plates were used with a model breast cancer human cell line.

Arctigenin Inhibits Apoptosis, Extracellular Matrix Degradation, and Inflammation in Human Nucleus Pulposus Cells by Up-Regulating miR-483-3p

[Journal of Clinical Laboratory Analysis] Interleukin (IL)-1β was adopted to induce human nucleus pulposus cells as a cell model for intervertebral disc degeneration.

Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via α6β1 Integrin-Fyn-RhoA-ROCK Signaling

[Stem Cells and Development] The impact of laminin-511 on hiPSC on α6β1 integrin-Fyn-RhoA-ROCK signaling was discussed and explored along with validation experiments.

miR-218 Affects the ECM Composition and Cell Biomechanical Properties of Glioblastoma Cells

[Journal of Cellular and Molecular Medicine] Investigators reported that ECM composition was partially regulated at the post-transcriptional level by miRNA.

Efficient Engineering of Human Auricular Cartilage through Mesenchymal Stem Cell Chaperoning

[Journal of Tissue Engineering and Regenerative Medicine] To significantly decrease the number of chondrocytes required for human elastic cartilage engineering, the authors co-cultured human mesenchymal stem cells with auricular chondrocyte to promote healthy elastic cartilage formation.

A Sonication-Induced Silk-Collagen Hydrogel for Functional Cartilage Regeneration

[Journal of Materials Chemistry B] Scientists developed a sonication-induced silk-collagen composite hydrogel and investigated its physicochemical and biological properties compared with a collagen hydrogel and a non-sonicated silk-collagen composite hydrogel.

Fibroblast Growth Factor 2 Inhibits Myofibroblastic Activation of Valvular Interstitial Cells

[Plos One] Investigators isolated valvular interstitial cells from diseased human valves and treated these cells with FGF-2 and TGF-β to elucidate effect of these growth factors on several myofibroblastic outcomes, in particular immunocytochemistry and gene expression.

Systematic Analysis of Actively Transcribed Core Matrisome Genes Across Tissues and Cell Phenotypes

[Matrix Biology] Integration of the core matrisome and curated FANTOM5 SSTAR data creates a unique tool that provides insight into the promoter-level expression of ECM-encoding genes in a tissue- and cell-specific manner.

Stoichiometric Post Modification of Hydrogel Microparticles Dictates Neural Stem Cell Fate in Microporous Annealed Particle Scaffolds

[Advanced Materials] To create plain hydrogel microparticles (HMPs) that could later be converted to contain different types of bioactivities, scientists utilized the inverse electron-demand Deiels-Alder reaction between tetrazine and norbornene, which allowed them to post modify plain HMPs stoichiometrically.

Disgraced Italian Surgeon Convicted of Criminal Harm to Stem Cell Patient

[ScienceInsider] A surgeon who just a decade ago was celebrated around the globe as a pioneer in stem cell transplants has been convicted of one count of “causing bodily harm,” a felony, in a Swedish court.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.