Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Collagen Fibril Orientation Instructs Fibroblast Differentiation Via Cell Contractility

[Advanced Science] By characterizing the mechanical properties of reconstituted matrices, it was found that the elastic modulus of collagen matrices was enhanced with an increase in the alignment degree.

UO’s Knight Campus Reveals Design of Second Science Building and New Engineering Program

[Oregon Public Broadcasting] The University of Oregon’s Knight Campus has released design details of its second science building now under construction. The sprawling facility will enable the evolution of a new bioengineering program at the unviersity.

Discoidin Domain Receptors; an Ancient Family of Collagen Receptors Has Major Roles in Bone Development, Regeneration and Metabolism

[Frontiers in Dental Medicine] The authors focus on the roles of discoidin domain receptors in mineralized tissue development as well as related functions in abnormal bone formation, regeneration and metabolism.

An rRNA Fragment in Extracellular Vesicles Secreted by Human Airway Epithelial Cells Increases the Fluoroquinolone Sensitivity of P. aeruginosa

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Researchers showed that extracellular vesicles secreted by primary human alveolar epithelial cells transfered multiple distinct sRNA fragments to P. aeruginosa that were predicted to target the three subunits of the fluoroquinolone efflux pump MexHI-OpmD, thus increasing antibiotic sensitivity.

The Circadian Clock and Extracellular Matrix Homeostasis in Aging and Age-Related Diseases

[American Journal Of Physiology-Cell Physiology] Scientists summarize new work linking the ECM with circadian clocks and tissue ageing. They discuss how the changes in the biomechanical and biochemical properties of ECM during ageing may contribute to circadian clock dysregulation.

Fibrous Viscoelastic Extracellular Matrix Assists Precise Neuronal Connectivity

[Advanced Functional Materials] By developing a label-free traction force microscopy technique, the force networks among neurons are presented, validating that the fibrous matrix-transmitted paratensile signals can assist the axon pathfinding.

LOXL4, but Not LOXL2, Is the Critical Determinant of Pathological Collagen Cross-Linking and Fibrosis in the Lung

[Science Advances] Scientists reported that, while its expression was increased in fibrotic lungs, genetic ablation of LOXL2 only led to a modest reduction of pathological collagen cross-linking but not fibrosis in the lung.

Hydrogel-in-Hydrogel Live Bioprinting for Guidance and Control of Organoids and Organotypic Cultures

[Mesenchymal Cell News, Organoid News] Modulation of hydrogel characteristics over time and according to culture evolution is often not possible. Investigators overcame these limitations by developing a hydrogel-in-hydrogel live bioprinting approach that enables the dynamic fabrication of instructive hydrogel elements within pre-existing hydrogel-based organ-like cultures.

NHR-23 Activity Is Necessary for C. elegans Developmental Progression and Apical Extracellular Matrix Structure and Function

[Development] NHR-23 expression oscillated in the epidermal epithelium, and soma-specific NHR-23 depletion caused severe developmental delay and death.

Cell Shape and Forces in Elastic and Structured Environments: From Single Cells to Organoids

[Advanced Functional Materials] Extracellular stiffness guided migration of single cells and collectives as well as differentiation and developmental processes. In confined environments, cell division patterns are altered, cell death or extrusion might be initiated, and other modes of cell migration became possible.

Tenascin-C Activation of Lung Fibroblasts in a 3D Synthetic Lung Extracellular Matrix Mimic

[Advanced Materials] Researchers developed a synthetic, bioactive hydrogel that mimics the native lung modulus and includes a representative distribution of the most abundant extracellular matrix peptide motifs responsible for integrin binding and matrix metalloproteinase-mediated degradation in the lung, which enabled quiescent culture of human lung fibroblasts.

Living Microecological Hydrogels for Wound Healing

[Science Advances] As the hydrogel consisted of thermosensitive Pluronic F-127 and wet-adhesive polydopamine, the living microecological hydrogel could keep liquid at a low temperature while quickly solidifying and tightly adhering to the wound bed.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.