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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Interpenetrating Networks
[Advanced Materials] The authors introduced a polyethylene glycol-based hydrogel model. The effects of 4D-triggered network mechanical changes on human mesenchymal stem cell morphology and Hippo signaling, as well as Caco-2 colorectal cancer cell mechanomemory using transcriptomics and metabolic assays were investigated.
Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
[Cancer Research] Through analyses of single-cell sequencing data, investigators identified a population of cancer-associated fibroblasts expressing high levels of sulfatase 1 (SULF1), which was associated with poor prognosis in colorectal cancer (CRC) patients.
Development of Neural Cells and Spontaneous Neural Activities in Engineered Brain-Like Constructs for Transplantation
[Advanced Healthcare Materials] Scientists constructed a biomimetic material system comprising gelatin, alginate, and fibrinogen for neural progenitor cell constructs using 3D printing, which exhibited excellent formability, stability, and developmental functions in vitro, as well as biocompatibility and integration into the hippocampus in vivo.
The Multifaceted Role of the Stroma in the Healthy Prostate and Prostate Cancer
[Journal of Translational Medicine] Scientists focus on the characteristics and functions of the prostate associated fibroblasts and of the extracellular matrix in health and cancer.
Rice’s Aryeh Warmflash Awarded $1.6M NIH Grant for Research on Early Human Development
[Rice University] Researchers at Rice University are working to understand how a single cell evolves into the complex network of specialized cells that form the human body. Funded by a $1.6 million grant from the National Institutes of Health, the research team’s new study could advance knowledge of developmental disorders and contribute to the future of regenerative medicine.
CAF-Induced Physical Constraints Controlling T Cell State and Localization in Solid Tumors
[Nature Reviews Cancer] Scientists delve into the complex crosstalk among cancer cells, cancer-associated fibroblasts (CAFs), and immune cells, highlighting the effects of CAF-induced ECM remodeling on T cell functions and offering insights into the potential of targeting ECM components to improve cancer therapies.
Targeting the Peripheral Neural-Tumour Microenvironment for Cancer Therapy
[Nature Reviews Drug Discovery] Investigators review the dynamics of the tumor microenvironment with an emphasis on tumor innervation by the peripheral nervous system, as well as current preclinical and clinical evidence of the benefits of targeting the nervous system in cancer.
Hydrogel Microneedle Patches Loaded with Stem Cell Mitochondria-Enriched Microvesicles Boost the Chronic Wound Healing
[ACS Nano] Investigators designed an effective hydrogel microneedle patch loaded with stem cell-derived mitochondria-rich extracellular vesicles to gradually release and deliver mitochondria into the wound tissues and boost wound healing.
Gradient-Induced Instability in Tumor Spheroids Unveils the Impact of Microenvironmental Nutrient Changes
[Scientific Reports] Scientists developed an in vitro tumor invasion assay to investigate cell invasiveness in tumor spheroids under a chemotactic stimulus.
Tempo Therapeutics Announces First Patient Dosed in Clinical Trial of TT101 for Tissue Repair in Skin Cancer Surgery
[Tempo Therapeutics, Inc. (Newswise)] Tempo Therapeutics, Inc. announced the dosing of the first patients in the MOSAIC Trial, a clinical trial for TT101, the company’s lead candidate for tissue regeneration using its proprietary MAP technology. TT101 is a flowable and integrative scaffold, showing non-immunogenic and regenerative tissue responses in large animal studies of soft tissue repair.
Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds
[Advanced Materials] Scientists discuss the modular design of engineered protein-based hydrogels from both a molecular- and network-level perspective, and summarize recent progress and case studies to highlight the diverse strategies used to construct biomimetic scaffolds.
Effect of 3-Hydrazinylquinoxaline-2-Thiol Hydrogel on Skin Wound Healing Process in Diabetic Rats
[Scientific Reports] Scientists topically tested the wound healing effect of 3-hydrazinylquinoxaline-2-thiol hydrogel in a full-thickness excision wound in streptozotocin-induced type 1 diabetic rats.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
