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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Decellularized Extracellular Matrix Scaffold Loaded with Regulatory T Cell-Conditioned Medium Induces M2 Macrophage Polarization
[Biomaterials Research] Investigators proposed that regulatory T cell-conditioned medium effectively promoted M2 polarization of macrophages induced by decellularized ECM materials in inflammatory environments.
Targeted Immunotherapy Rescues Pulmonary Fibrosis by Reducing Activated Fibroblasts and Regulating Alveolar Cell Profile
[Nature Communications] Researchers evaluated the therapeutic activity of transient antifibrotic chimeric antigen receptor (CAR) T cells generated via a novelly-designed lipid nanoparticle-messenger RNA system and explored the regeneration mechanisms of lung in a male mouse model of bleomycin-induced pulmonary fibrosis.
Border-Zone Cardiomyocytes and Macrophages Regulate Extracellular Matrix Remodeling to Promote Cardiomyocyte Protrusion during Cardiac Regeneration
[Nature Communications] Single-cell RNA-sequencing revealed the expression of mmp14b, encoding a membrane-anchored matrix metalloproteinase, in several cell types at the border zone. Genetic mmp14b mutation led to decreased macrophage recruitment, collagen degradation, and subsequent cardiomyocyte protrusion into injured tissue.
Macrophages and Fibroblasts As Regulators of the Immune Response in Pancreatic Cancer
[Nature Immunology] Scientists provide an overview of the heterogeneity of cancer-associated fibroblasts and tumor-associated macrophages, how they establish an immunosuppressive microenvironment and their collaboration in the remodeling of the ECM.
Effects of Embryonic Origin, Tissue Cues, and Pathological Signals on Fibroblast Diversity in Humans
[Nature Cell Biology] The authors provide a global overview of the expanding compendium of fibroblast cell types and states, their diverse lineage origins, and multifaceted functions across various human organs.
Fibroblast Activation Protein (FAP)+ Cancer-Associated Fibroblasts Induce Macrophage M2-Like Polarization via the Fibronectin 1-Integrin α5β1 Axis in Breast Cancer
[Oncogene] Through integrated analysis of single-cell RNA sequencing data, clinical specimens, and in vivo and in vitro experiments, scientists identified cancer-associated fibroblasts expressing fibroblast activation protein as the predominant stromal population associated with poor clinical outcomes and immunosuppressive features.
Hydrogels with Multiple RGD Presentations Increase Cell Adhesion and Spreading
[Acta Biomaterialia] Scientists introduced a synthetic hydrogel platform where they could independently tune storage modulus, stress relaxation, and the mobility of cell adhesion peptides.
Lab-Grown Teeth Might Become an Alternative to Fillings following Research Breakthrough
[King's College London] Adults could one day grow their own replacement teeth instead of having fillings – as scientists make a key discovery.
Multifaceted Roles of OCT4 in Tumor Microenvironment: Biology and Therapeutic Implications
[Leukemia] The authors review recent evidence showing that OCT4 expressed in cancer stem cells plays a multifaceted role in shaping the TME by interacting with the cellular TME components, including cancer-associated fibroblasts, tumor endothelial cells, tumor-infiltrating immune cells, as well as the non-cellular TME components, such as ECM.
THBS2-Producing Matrix CAFs Promote Colorectal Cancer Progression and Link to Poor Prognosis via the CD47-MAPK Axis
[Cell Reports] Employing single-cell RNA sequencing data of colorectal cancer (CRC), researchers identified a subset of matrix cancer-associated fibroblasts as a critical subtype that secretes THBS2, a molecule linked to advanced cancer stages and poor prognosis.
Snail1 As a Key Prognostic Biomarker of Cancer-Associated Fibroblasts in Breast Tumors
[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors summarize recent findings from patient samples and mouse models of breast cancer, focusing on gene signatures identified by single-cell RNA sequencing that define cancer-associated fibroblast subtypes and predict cancer prognosis.
Fibromodulin Selectively Accelerates Myofibroblast Apoptosis in Cutaneous Wounds by Enhancing Interleukin 1β Signaling
[Nature Communications] Researchers found that fibromodulin induced myofibroblast apoptosis after wound closure to reduce scarring in small and large animal models.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
