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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Combining Top-Down and Bottom-Up: An Open Microfluidic Microtumor Model for Investigating Tumor Cell-ECM Interaction and Anti-Metastasis
[Small] The Under-oil Open Microfluidic System microtumor model – allowing a controlled but also self-organized, cell-directed tumor-ECM microenvironment in an open microfluidic configuration – was used to test an anti-metastasis drug with a triple-negative breast cancer cell line.
Human Hair Follicle Mesenchymal Stem Cell-Derived Exosomes Attenuate UVB-Induced Photoaging via the miR-125b-5p/TGF-β1/Smad Axis
[Biomaterials Research] The authors revealed that exosomes derived from human hair follicle mesenchymal stem cells effectively enhanced the migration and proliferation of human dermal fibroblasts (HDFs) and upregulated the expressions of TGF-β1, p-Smad2/p-Smad3, collagen type 1, and collagen type 3.
Harnessing the Tumor Microenvironment: Targeted Cancer Therapies through Modulation of Epithelial-Mesenchymal Transition
[Journal of Hematology & Oncology] The authors scrutinize the key players in the tumor microenvironment (TME) and the TME's contribution to epithelial-mesenchymal transition, emphasizing avenues to therapeutically disrupt the interactions between the various TME components.
Personalizing Glioblastoma Medicine: Explant Organoid Applications, Challenges, and Future Perspectives
[Acta Neuropathologica Communications] The authors provide a review of existing brain cancer organoid technologies, in vivo xenograft approaches, evaluate in-detail the key advantages and limitations of this rapidly emerging technology, and consider solutions to overcome these difficulties.
Perivascular Cells Function as Key Mediators of Mechanical and Structural Changes in Vascular Capillaries
[Science Advances] Researchers used a microphysiological model of capillaries on a chip mimicking the characteristics of healthy or fibrotic collagen to test the hypothesis that perivascular cells mediated the response of vascular capillaries to mechanical and structural changes in the human ECM.
Endothelial Tip-Cell Position, Filopodia Formation, and Biomechanics Require BMPR2 Expression and Signaling
[Communications Biology] Researchers combined genetic, biochemical, and molecular methods together with 3D traction force microscopy, which revealed an essential role of BMPR2 for actin-driven filopodia formation and mechanical properties of endothelial cells.
Regulation of Fibronectin and Collagens Type I, III, and VI by TNF-α, TGF-β, IL-13, and Tofacitinib
[Scientific Reports] Investigators showed that 12-day fibroblast culture with TNF-α or IL-13 induced fibrogenesis, marked by progressively increasing type III and VI collagen formation, and that TGF-β1 co-stimulation amplified these effects.
Fesarius Therapeutics, Inc. Announces FDA 510(K) Clearance for Dermisphere Hydrogel Dermal Regeneration Template
[Fesarius Therapeutics, Inc.] Fesarius Therapeutics, Inc. announceed that the US FDA has granted 510(k) clearance for its DermiSphere hydrogel Dermal Regeneration Template. This technology represents a new class of collagen-based dermal matrices designed for tissue integration and revascularization for improved wound healing and reduction of time to healing.
Chemically Defined and Dynamic Click Hydrogels Support Hair Cell Differentiation in Human Inner Ear Organoids
[Stem Cell Reports] The authors implemented an alternative, chemically defined, dynamic hydrogel to support the differentiation of human inner ear organoids. Specifically, thiol-norbornene and hydrazide-aldehyde click chemistries were used to fabricate inner ear organoid-laden, gelatin-based scaffolds.
Magnetic Nanoactuator-Protein Fiber Coated Hydrogel Dressing for Well-Balanced Skin Wound Healing and Tissue Regeneration
[ACS Nano] Researchers adopted a “dual-wheel-driven” strategy to modify the surface of methacrylated gelatin hydrogel with highly aligned magnetic nanocomposites-protein fiber assemblies consisting of photothermal responsive antibacteria superparamagnetic nanocomposites-fibrinogen complexes as the building blocks.
Silk Fibroin-Based Hydrogels for Cartilage Organoids in Osteoarthritis Treatment
[Theranostics] Scientists reviewed the studies of cartilage organoids and silk fibroin (SF)-based hydrogels. The advantages of SF-based hydrogels in constructing cartilage organoids and the iterative optimization of cartilage organoids through designing hydrogels by using artificial intelligence calculation are also discussed.
Extracellular Matrix in Vascular Homeostasis and Disease
[Nature Reviews Cardiology] The authors explore various aspects of extracellular matrix biology in vascular development, disorders and aging, emphasizing the effect of the ECM on disease initiation and progression.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
