Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Integrin Signalling in Joint Development, Homeostasis and Osteoarthritis

[Nature Reviews Rheumatology] Integrins are key regulators of cell–matrix interactions during joint development and joint tissue homeostasis, as well as in the development of osteoarthritis.

Bucknell Professor Receives $200,000 Research Grant

[The Daily Item] A Bucknell University professor has received nearly $200,000 in grant funding to research therapeutic applications of ultrasound and the expansion of regenerative medicine education for underrepresented college and high school students.

The Impact of Tertiary Lymphoid Structures on Tumor Prognosis and the Immune Microenvironment in Non-Small Cell Lung Cancer

[Scientific Reports] Scientists accessed The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases to obtain mRNA sequencing data and clinical information as the TCGA cohort, and used our own sample of 53 advanced non-small cell lung cancer as a study cohort.

Cartilage Lacuna-Biomimetic Hydrogel Microspheres Endowed with Integrated Biological Signal Boost Endogenous Articular Cartilage Regeneration

[Bioactive Materials] Investigators developed a cartilage lacuna-like hydrogel microsphere system endowed with integrated biological signals, enabling sequential immunomodulation and endogenous articular cartilage regeneration.

Fabrication of ECM Protein Coated Hollow Collagen Channels to Study Peripheral Nerve Regeneration

[Scientific Reports] Researchers developed a reproducible in vitro hollow channel collagen gel construct to investigate peripheral nerve regeneratio by exploring the influence of key ECM proteins on axonal growth and regeneration.

Alveolar Fibroblast Lineage Orchestrates Lung Inflammation and Fibrosis

[Nature] Scientists showed that lung-specialized alveolar fibroblasts took on multiple molecular states with distinct roles in facilitating responses to fibrotic lung injury.

Mechanical Forces Remodel the Cardiac Extracellular Matrix During Zebrafish Development

[Development] Using zebrafish as a model and focusing on stages when cardiac valves and trabeculae form, the authors found that altering cardiac contraction impaired cardiac ECM remodeling.

A Maternal Brain Hormone That Builds Bone

[Nature] Investigators reported that brain-derived cellular communication network factor 3 secreted from KISS1 neurons of the arcuate nucleus filled this void and functioned as a potent osteoanabolic factor to build bone in lactating females.

These Period Pads Solidify Blood to Prevent Leaks

[Nature News] A biodegradable molecule derived from seaweed that forms a gel when it comes into contact with blood could address leakage of menstrual products, according to a recently published study.

Wolchok Promoted to Professor, Lands Five-Year Appointment as Head of Biomedical Engineering

[University of Arkansas] College of Engineering Dean Kim Needy has announced the five-year appointment of Jeffrey Wolchok to lead the Department of Biomedical Engineering, which he helped found in 2012 and has led as interim department head for the past two years.

Intracellular Cartilage Oligomeric Matrix Protein Augments Breast Cancer Resistance to Chemotherapy

[Cell Death & Disease] Investigators showed that cartilage oligomeric matrix protein (COMP) expression led to increased cancer cell survival and attenuated apoptosis under treatment with several chemotherapeutic drugs, anti-HER2 targeted treatment, and endocrine therapy in several breast cancer cell lines tested.

Bioengineered Niches That Recreate Physiological Extracellular Matrix Organisation to Support Long-Term Hematopoietic Stem Cells

[Nature Communications] Researchers reported the creation of a bioengineered long-term reconstituting hematopoietic stem cells maintenance niche that recreated physiological ECM organisation, using soft collagen type-I hydrogels to drive nestin expression in perivascular stromal cells.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.