Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Extracellular Matrix News
Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Subscribe|Follow Us On
Histaminylation Alters Collagen Matrix Mechanics and Attenuates Cardiac Fibrosis Post-Myocardial Infarction via Mechanotransduction Signaling Axis
[Signal Transduction and Targeted Therapy] Investigators identified histaminylation in cardiac type I collagen isolated from mice 7 days after acute myocardial infarction by mass spectrometry.
Macropinocytosis Inhibition Attenuates Profibrotic Responses in Lung Fibroblasts and Pulmonary Fibrosis Models
[Journal of Clinical Investigation] Researchers studied the role of macropinocytosis in experimental pulmonary fibrosis models. They found that macropinocytosis is increased in human lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.
A Stretch-Responsive Fibroblast Program Promotes Epidermal Stem Cell Self-Renewal during Skin Expansion
[Nature Communications] Scientists mapped the fibroblast transcriptional response to stretching in vivo and demonstrate that stretching forces fibroblasts to exit their quiescent state and restart proliferation.
Glycosylated Extracellular Matrix Drives Immune Suppression by Modulating Macrophage-T Cell Crosstalk in Triple-Negative Breast Cancer
[Nature Communications] Investigators reported that ECM immunomodulation in triple-negative breast cancer is mediated by post-translational glycan modifications on ECM proteins.
Extracellular Matrix Biomarkers of T-Cell Infiltration and Tumor Fibrosis Predict Response to Nivolumab ± Ipilimumab with SBRT in Biliary Tract Cancer: Insights from the CheckPAC Trial
[BMC Medicine] Researchers investigated the pharmacodynamic and predictive potential of liquid, ECM-derived biomarkers reflecting cytotoxic T cell activity and fibrotic activity in patients with metastatic biliary tract cancer receiving combined immunotherapy and radiotherapy.
Transcription Factor ID3 Promotes Fibroblast Differentiation and Proliferation in Lung Fibrosis through Augmenting the TGF-β Signaling Pathway
[Molecular Immunology] Scientists investigated fibroblast lineage progression using single-cell RNA-sequencing data from fibroblast-enriched populations in bleomycin-induced mouse models and human idiopathic pulmonary fibrosis samples.
Hidden Architecture of Resistance: The Extracellular Matrix in Melanoma’S Immune Landscape
[Seminars in Cancer Biology] The authors focus on the critical roles of ECM molecules, namely collagen, fibronectin, laminin, hyaluronic acid, galectin, and matrix metalloproteinase, in shaping the melanoma tumor immune microenvironment.
Engitix Announces Strategic Collaboration with GSK to Advance First-in-Class Targets for Liver Fibrosis Regression
[Engitix, Ltd.] Engitix, Ltd. announced a strategic research collaboration and option agreement with GSK to identify and validate novel therapeutic targets driving liver fibrosis regression.
Smart Microneedles Regulate Reactive Oxygen Species and Deliver Matrix Metalloproteinases for Pathological Scar Treatment
[ACS Nano] To modulate the oxidative microenvironment and remodel the ECM, a smart microneedle capable of regulating reactive oxygen species and delivering matrix metalloproteinase functions was developed.
Artificial Self-Mineralized MSCs’ Niche Mimics Dynamic Variations of ECM Modulus during Osteogenesis for Rapid Bone Regeneration
[Biomaterials] The development of artificial scaffolds capable of providing dynamically evolving mineralized niches for mesenchymal stem cells remains challenging, and the underlying osteogenic mechanisms are still poorly understood. A hierarchical graphene-doped polymethyl methacrylate scaffold was fabricated via vapor-induced phase separation.
Mesangial Cell-Derived Extracellular Matrix Protein 1 Is Essential for Maintaining Mesangial Matrix Homeostasis and Glomerular Architecture
[Journal of the American Society of Nephrology] Researchers investigated the role of mesangial cell–derived ECM protein 1 in regulating mesangial matrix homeostasis and glomerular structure in mice.
Phosphorylation Remodels the Mitotic Centrosome Matrix to Generate Bipartite γ-Tubulin Complex Docking Sites
[Science Advances] Scientists showed that SPindle Defective-5) contains two regions, phospho-regulated γTuC binding region 1 (PRGB1) and PRGB2, that are each sufficient for polo-like kinase 1 phosphorylation–regulated γTuC binding.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
