Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

PROX1 Induction by Autolysosomal Activity Stabilizes Persister-Like State of Colon Cancer via Feedback Repression of the NOX1-mTORC1 Pathway

[Cell Reports] Researchers showed that enhanced autolysosomal activity mediated by mTORC1 inhibition induced PROX1 expression and that PROX1 induction in turn inhibited NOX1-mTORC1 activation.

macroH2A2 Antagonizes Epigenetic Programs of Stemness in Glioblastoma

[Nature Communications] With omics and functional assays deploying patient-derived in vitro and in vivo models, scientists showed that macroH2A2 shaped chromatin accessibility at enhancer elements to antagonize transcriptional programs of self-renewal.

Elevated FOXG1 in Glioblastoma Stem Cells Cooperates with Wnt/β-Catenin To Induce Exit From Quiescence

[Cell Reports] Using small-molecule modulators and genetic perturbations, researchers identified a synergistic interaction between FOXG1 and Wnt/β-catenin signaling.

Histone Lysine Methyltransferase SMYD3 Promotes Oral Squamous Cell Carcinoma Tumorigenesis via H3K4me3-Mediated HMGA2 Transcription

[Clinical Epigenetics] The authors investigated the biological functions and mechanisms involved in the SET and MYND domain-containing protein 3 (SMYD3)-mediated tumorigenesis of oral squamous cell carcinoma utilizing bioinformatic approaches and validation assays.

JWA Inhibits Nicotine-Induced Lung Cancer Stemness and Progression Through CHRNA5/AKT-Mediated JWA/SP1/CD44 Axis

[Ecotoxicology and Environmental Safety] Scientists reported for the first time that JWA was significantly downregulated in smoking-related lung cancer and associated with overall survival. Nicotine exposure reduced JWA expression in a dose-dependent manner.

Phosphorylation of IWS1 by AKT Maintains Liposarcoma Tumor Heterogeneity Through Preservation of Cancer Stem Cell Phenotypes and Mesenchymal-Epithelial Plasticity

[Oncogenesis] Researchers showed that the AKT-mediated phosphorylation of the transcription elongation factor IWS1, promoted the maintenance of CSCs in both cell and xenograft models of liposarcoma.

SNHG1, a KLF4-Upregulated Gene, Promotes Glioma Cell Survival and Tumorigenesis Under Endoplasmic Reticulum Stress by Upregulating BIRC3 Expression

[Journal of Cellular and Molecular Medicine] The authors investigated the altered lncRNAs upon endoplasmic reticulum (ER) stress in glioma and found that small nucleolar RNA host gene 1 (SNHG1) was markedly increased in response to ER stress.

FTO Promotes the Stemness of Gastric Cancer Cells

[Dna And Cell Biology] After gastric CSCs were isolated, it was found that fat mass and obesity (FTO) protein expression was increased in gastric CSCs and stemness of gastric cancer cells was reduced after the FTO gene knockdown.

Isoliquiritigenin Inhibits circ0030018 To Suppress Glioma Tumorigenesis via the miR-1236/HER2 Signaling Pathway

[MedComm] Researchers treated glioma cells with isoliquiritigenin (ISL), and circRNA expression levels were detected. Circ0030018 was found significantly downregulated by ISL. Therefore, they explored circ0030018 expression profiles and functions in glioma.

Cancer Stem Cells in Colorectal Cancer: Implications for Targeted Immunotherapies

[Journal of Gastrointestinal Cancer] The authors review the biological significance of stemness and the results of potential colorectal CSC (CRCSC)-based targeted immunotherapies. They pointed out the barriers to targeting CRCSCs in vivo and highlight new strategies based on synthetic and biogenic nanocarriers for the development of future anti-CRCSC trials.

Researcher Receives National Award for Cancer Care Innovation

[Queen's University] A post-doctoral researcher at Queen’s University Cancer Research Institute has been recognized nationally for her groundbreaking work to monitor breast cancer using a simple, routine blood test.

Trethera Receives $2 Million National Cancer Institute Grant for Advancement of Clinically Relevant Biomarkers in Phase I Trial

[Trethera Corporation (GlobeNewswire)] Trethera Corporation (“Trethera”) announced that it was awarded a $2 million Small Business Innovative Research grant from the National Cancer Institute. The grant will fund additional patient dosing studies to identify predictive biomarkers of activity and target engagement of TRE-515 in solid tumors.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.