Researchers investigated the potential effect of combining Rovalpituzumab tesirine and CBL0137 in small cell lung cancer to eradicate tumor-initiating cells more effectively.
[British Journal of Cancer]
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Researchers explored whether targeting nitric oxide in estrogen positive breast cancer cells impacts cancer stem cell subpopulation and sensitivity to hormonal therapy with tamoxifen.
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López-Sánchez, L. M., Mena, R., Guil-Luna, S., Mantrana, A., Peñarando, J., Toledano-Fonseca, M., Conde, F., De la Haba-Rodríguez, J. R., Aranda, E., & Rodríguez-Ariza, A. (2020). Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells. Laboratory Investigation, 1–12. https://doi.org/10.1038/s41374-020-00507-z Cite
Mitochondrial inhibition may be a viable strategy for eradicating cancer stem cells. Medicinal chemistry research over the last decade has synthesized and characterized “vehicles” capable of transporting novel or existing pharmacophores to mitochondrial tumor cells, based on mechanisms that exploit the physicochemical properties of the vehicles and the inherent properties of the mitochondria.
[International Journal of Molecular Sciences]
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Researchers showed the effect of calcium electroporation on immune cells, using melanoma-conditioned bone marrow-derived macrophages.
Human CD24–/CD44+ breast cancer stem cells (BCSCs) were treated with andrographolide in vitro for 24 hours. The cytotoxic effect of andrographolide on BCSCs was compared to that on human mesenchymal stem cells.
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Wanandi, S. I., Limanto, A., Yunita, E., Syahrani, R. A., Louisa, M., Wibowo, A. E., & Arumsari, S. (2020). In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells. PLOS ONE, 15(11), e0240020. https://doi.org/10.1371/journal.pone.0240020 Cite
Investigators showed that histone lysine demethylase 4D (JMJD2D) expression was increased in liver cancer stem-like cells (LCSCs); downregulation of JMJD2D inhibited the self-renewal of LCSCs in vitro and in vivo and inhibited the lung metastasis of LCSCs by reducing the survival and the early lung seeding of circulating LCSCs.
[Journal of Biological Chemistry]
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Deng, Y., Li, M., Zhuo, M., Guo, P., Chen, Q., Mo, P., Li, W., & Yu, C. (2020). Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression. Journal of Biological Chemistry, jbc.RA120.015335. https://doi.org/10.1074/jbc.RA120.015335 Cite
The authors investigate and elucidate the relationship between the effective signaling pathways in CSCs, autophage, and epithelial-mesenchymal transition, which could play an effective role in determining appropriate therapeutic goals.
[Biomedicine & Pharmacotherapy]
Scientists investigated the spatial heterogeneity of cancer stem cell-features with the aim of identifying the unique hepatocellular carcinoma patient subgroups amenable to adjuvant treatment.
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Krause, J., von Felden, J., Casar, C., Fründt, T. W., Galaski, J., Schmidt, C., Jung, C., Ittrich, H., Weidemann, S. A., Krech, T., Heumann, A., Li, J., Fischer, L., Sauter, G., Lohse, A. W., Wege, H., & Schulze, K. (2020). Hepatocellular carcinoma: Intratumoral EpCAM-positive cancer stem cell heterogeneity identifies high-risk tumor subtype. BMC Cancer, 20(1), 1130. https://doi.org/10.1186/s12885-020-07580-z Cite
Investigators showed that a knock-in reporter mouse for the stem cell gene Musashi 2 allowed identification of leukemia stem cells in aggressive myeloid malignancies, and provided a strategy for defining their core dependencies.
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Spinler, K., Bajaj, J., Ito, T., Zimdahl, B., Hamilton, M., Ahmadi, A., Koechlein, C. S., Lytle, N., Kwon, H. Y., Anower-E-Khuda, F., Sun, H., Blevins, A., Weeks, J., Kritzik, M., Karlseder, J., Ginsberg, M. H., Park, P. W., Esko, J. D., & Reya, T. (2020). A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. Nature Communications, 11(1), 5998. https://doi.org/10.1038/s41467-020-19782-x Cite
Researchers analyzed clonal hematopoiesis (CH) in blood samples from a pair of twin astronauts over four years in bulk and fractionated cell populations using a targeted CH panel, linked-read whole-genome sequencing, and deep RNA sequencing.
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Trinchant, N. M., MacKay, M. J., Chin, C., Afshinnekoo, E., Foox, J., Meydan, C., Butler, D., Mozsary, C., Vernice, N. A., Darby, C., Schatz, M. C., Bailey, S. M., Melnick, A. M., Guzman, M., Bolton, K., Braunstein, L. Z., Garrett-Bakelman, F., Levine, R. L., Hassane, D., & Mason, C. E. (2020). Clonal Hematopoiesis Before, During, and After Human Spaceflight. Cell Reports, 0(0). https://doi.org/10.1016/j.celrep.2020.108458 Cite
Using Western blotting and qRT-PCR analyses, investigators revealed that in the T47D and BT20 breast cancer cell lines, astaxanthin inhibited expression of pontin and mutp53, as well as the Oct4 and Nanog cancer stem cell stemness genes.