HOTAIR Contributes to Stemness Acquisition of Cervical Cancer through Regulating miR-203 Interaction with ZEB1 on Epithelial-Mesenchymal Transition

Cisplatin-resistant and serum-free cultured cells exhibited stem cells properties. Cervical cancer stem cells exhibited greater invasion and migration compared with their parental cells, which was similar to cells overexpressing HOTAIR.
[Journal of Oncology]
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SNAI1-Mediated Transcriptional Regulation of Epithelial-to-Mesenchymal Transition Genes in Breast Cancer Stem Cells

Researchers performed in silico analysis of microarray data from luminal, Her2+, and triple-negative breast cancer cell lines and identified 15 relatively unexplored epithelial-to-mesenchymal (EMT)-related differentially expressed genes along with the markedly high expression of EMT-transcription factor, SNAI1.
[Cellular Signalling]
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Gly-tRF Enhances LCSC-Like Properties and Promotes HCC Cells Migration by Targeting NDFIP2

The expression of glycine tRNA-derived fragment was measured by qRT-PCR. Flow cytometric analysis and sphere formation assays were used to determine the properties of liver CSCs (LCSCs). Transwell assays and scratch wound assays were performed to detect hepatocellular carcinoma cell migration.
[Cancer Cell International]
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A Novel Peptidomimetic Therapeutic for Selective Suppression of Lung Cancer Stem Cells over Non-Stem Cancer Cells

Investigators identified a highly specific peptidomimetic that selectively bound to the CSC subpopulation of lung cancer over the remaining cancer cells.
[Bioorganic Chemistry]
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Fine-Tuned Repression of Drp1 Driven Mitochondrial Fission Primes a ‘Stem/Progenitor-Like State’ to Support Neoplastic Transformation

Using a newly derived carcinogen transformed human cell model, researchers demonstrated that fine-tuned Drp1 repression primed a slow cycling ‘stem/progenitor-like state’, which was characterized by small networks of fused mitochondria and a gene-expression profile with elevated functional stem/progenitor markers and their regulators.
[eLife]
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RhoGTPase Signaling in Cancer Progression and Dissemination

After years of intensive research, scientists highlight the importance of relevant models in the Rho GTPase field, and they reflect on the therapeutic opportunities arising for cancer patients.
[Physiological Reviews]
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The Cross Talk between Gastric Cancer Stem Cells and the Immune Microenvironment: A Tumor-Promoting Factor

Scientists provide an overview of bidirectional interactions between cancer stem cells and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.
[Stem Cell Research & Therapy]
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Erasca Announces First Patient Dosed in HERKULES-3, a Phase Ib/II Gastrointestinal Cancer Master Protocol Evaluating ERAS-007 in Multiple Combinations

Erasca, Inc. announced dosing of the first patient in HERKULES-3, a Phase Ib/II master protocol clinical trial evaluating ERAS-007 in combination with various agents in patients with gastrointestinal cancer, with initial focus on patients with advanced colorectal cancer.
[Erasca, Inc.]
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International Regenerative Medicine Expert Will Lead CSU Translational Medicine Institute

Frank Barry, Ph.D., has been selected as the new director of the C. Wayne McIlwraith Translational Medicine Institute at Colorado State University. Barry’s research and interests include stem cell biology and the development of cell-based repair strategies for osteoarthritis.
[Colorado State University]
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Researchers Receive National Award to Further Study Muscular Dystrophy, Cancer and Heart Failure

Three Virginia Commonwealth University researchers were awarded funding that will support the expansion of their health research and translation of that research into improved care for patients.
[Virginia Commonwealth University]
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m6A Modification of circHPS5 Facilitates Cytoplasmic Export and Promotes Hepatocellular Carcinoma Progression by Enhancing HMGA2 Expression

Silencing of circHPS5 inhibited epithelial-mesenchymal transition and cancer stem-like cell (CSC) phenotypes. METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5.
[Molecular Therapy-Nucleic Acids]
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