Scientists attempted to clarify whether apigenin could improve the antitumor efficiency of cisplatin in lung cancer using cancer stem cells.
[Nutrition and Cancer-An International Journal]
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Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
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Gwynne, W. D., Shakeel, M. S., Girgis-Gabardo, A., Kim, K. H., Ford, E., Dvorkin-Gheva, A., Aarts, C., Isaac, M., Al-awar, R., & Hassell, J. A. (2020). Antagonists of the serotonin receptor 5A target human breast tumor initiating cells. BMC Cancer, 20(1), 724. https://doi.org/10.1186/s12885-020-07193-6 Cite
Investigators highlight the functional consequences of inhibiting and activating mitochondrial proteases and discuss their potential as therapeutic targets in acute myeloid leukemia.
[Stem Cells Translational Medicine]
Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
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Tadano, H., Tsukahara, T., Mizushima, E., Akamatsu, A., Watanabe, K., Nojima, I., Kubo, T., Kanaseki, T., Hirohashi, Y., Sato, N., & Torigoe, T. (2020). Development of an artificial antibody specific for HLA/peptide complex derived from cancer stem-like cell/cancer-initiating cell antigen DNAJB8. British Journal of Cancer, 1–8. https://doi.org/10.1038/s41416-020-1017-1 Cite
The authors demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
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Chen, Y., Niu, J., Li, L., Li, Z., Jiang, J., Zhu, M., Dong, T., Zhang, J., Shi, C., Xu, P., Lu, Y., Jiang, Y., Liu, P., & Chen, W. (2020). Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway. Life Sciences, 118158. https://doi.org/10.1016/j.lfs.2020.118158 Cite
The authors investigated the role of V1G1 in glioma stem cell small extracellular vesicles and their effects on primary brain cultures.
[Molecular Cancer Research]
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Bertolini, I., Storaci, A. M., Terrasi, A., Cristofori, A. D., Locatelli, M., Caroli, M., Ferrero, S., Altieri, D. C., & Vaira, V. (2020). Interplay between V-ATPase G1 and small EV-miRNAs modulates ERK1/2 activation in GBM stem cells and non-neoplastic milieu. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0078 Cite
The authors summarize recent literature regarding molecules and pathways and reviewed the effects of cancer stem cell biology during the formation of brain metastasis in triple-negative breast cancer.
Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]
Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
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Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
The authors identified DOCK6, a guanine nucleotide exchange factor for Rac1 and CDC42, as an independent biomarker for gastric cancer prognosis. Clinical findings indicate the positive correlation of higher DOCK6 expression with tumor size, depth of invasion, lymph node metastasis, vascular invasion, and pathological stage.
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Chi, H.-C., Tsai, C.-Y., Wang, C.-S., Yang, H.-Y., Lo, C.-H., Wang, W.-J., Lee, K.-F., Lai, L.-Y., Hong, J.-H., Chang, Y.-F., Tsai, M.-M., Yeh, C.-T., Wu, C. H., Hsieh, C.-C., Wang, L.-H., Chen, W.-J., & Lin, K.-H. (2020). DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01390-0 Cite
Smurf1 promotes cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.