Escherichia coli Foster Bladder Cancer Cell Line Progression via Epithelial Mesenchymal Transition, Stemness and Metabolic Reprogramming

In vitro infection of the T24 cell line with E. coli was performed to study the bacterial impact on bladder cancer cells. EMT markers were assessed using immunohistochemistry, western blot and RT-PCR. Stemness characteristics were monitored using RT-PCR.
[Scientific Reports]
Abd-El-Raouf, R., Ouf, S. A., Gabr, M. M., Zakaria, M. M., El-Yasergy, K. F., & Ali-El-Dein, B. (2020). Escherichia coli foster bladder cancer cell line progression via epithelial mesenchymal transition, stemness and metabolic reprogramming. Scientific Reports, 10(1), 18024. https://doi.org/10.1038/s41598-020-74390-5 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Exosomal LGALS9 in the Cerebrospinal Fluid of Glioblastoma Patients Suppressed Dendritic Cell Antigen Presentation and Cytotoxic T-Cell Immunity

Researchers found that glioblastoma multiforme-cerebrospinal fluid-exosomes (GBM-CSF-Exos) contained a unique protein, LGALS9 ligand, which bound to the TIM3 receptor of dendritic cells (DCs) in the CSF to inhibit antigen recognition, processing and presentation by DCs, leading to failure of the cytotoxic T-cell-mediated antitumor immune response.
[Cell Death & Disease]
Wang, M., Cai, Y., Peng, Y., Xu, B., Hui, W., & Jiang, Y. (2020). Exosomal LGALS9 in the cerebrospinal fluid of glioblastoma patients suppressed dendritic cell antigen presentation and cytotoxic T-cell immunity. Cell Death & Disease, 11(10), 1–16. https://doi.org/10.1038/s41419-020-03042-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

BCL11B Suppresses Tumor Progression and Stem Cell Traits in Hepatocellular Carcinoma by Restoring p53 Signaling Activity

In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
[Cell Death & Disease]
Yang, W.-J., Sun, Y.-F., Jin, A.-L., Lv, L.-H., Zhu, J., Wang, B.-L., Zhou, Y., Zhang, C.-Y., Wang, H., Hu, B., Wang, P.-X., Te, L., Pan, B.-S., Zhou, J., Fan, J., Yang, X.-R., & Guo, W. (2020). BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity. Cell Death & Disease, 11(10), 1–13. https://doi.org/10.1038/s41419-020-03115-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein

TRIM28 high level related to higher melanoma stemness as measured with several distinct scores and TRIM28HIGH-expressing melanoma cell lines possess the greater potential of melanosphere formation.
[Cancers]
Czerwinska, P., Jaworska, A. M., Wlodarczyk, N. A., & Mackiewicz, A. A. (2020). Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein. Cancers, 12(10), 2998. https://doi.org/10.3390/cancers12102998 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Agios Announces Withdrawal of European Marketing Authorization Application for TIBSOVO® as a Treatment for Relapsed or Refractory IDH1-mutant Acute Myeloid Leukemia

Agios Pharmaceuticals, Inc. announced the withdrawal of its European Marketing Authorization Application for TIBSOVO® for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-1 mutation.
[Agios Pharmaceuticals, Inc]
Press Release
Bookmark

No account yet? Register

0
Share

Genomic Instability in Circulating Tumor Cells

The authors focus on the contribution of chromosome instability studies to genetic heterogeneity in circulating tumor cells (CTCs) at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine.
[Cancers]
Freitas, M. O., Gartner, J., Rangel-Pozzo, A., & Mai, S. (2020). Genomic Instability in Circulating Tumor Cells. Cancers, 12(10), 3001. https://doi.org/10.3390/cancers12103001 Cite
Full Article
Bookmark

No account yet? Register

0
Share

TGFBI Modulates Tumor Hypoxia and Promotes Breast Cancer Metastasis

Researchers crossed the MMTV‐PyMT model of mammary gland tumorigenesis with a TgfbiΔ/Δ mouse, and studied the cancer stem cell (CSC) content of the tumors. They performed RNAseq on WT and KO tumours, and analyzed the tumor vasculature and the immune compartment by IHC and FACS.
[Molecular Oncology]
Fico, F., & Santamaria‐Martínez, A. (n.d.). TGFBI modulates tumour hypoxia and promotes breast cancer metastasis. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.12828 Cite
Abstract
Bookmark

No account yet? Register

0
Share

IL-8/CXCR2 Mediates Tropism of Human Bone Marrow-Derived Mesenchymal Stem Cells toward CD133+/CD44+ Colon Cancer Stem Cells

Scientists compared the effects of three tissue‐derived mesenchynal stem cells (MSCs) in vivo on colon tumor xenograft growth. Then, they analyzed the tropism of bone marrow‐derived MSCs toward normal intestinal epithelial cells, parental colon cancer cells, CD133/CD44, and CD133+/CD44+ colon cancer cells in vitro.
[Journal of Cellular Physiology]
Ma, X., Chen, J., Liu, J., Xu, B., Liang, X., Yang, X., Feng, Y., Liang, X., & Liu, J. (n.d.). IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+/CD44+ Colon cancer stem cells. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30080 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Reduced EGFR and Increased miR-221 Is Associated with Increased Resistance to Temozolomide and Radiotherapy in Glioblastoma

Researchers explored the underlying mechanisms behind treatment resistance and the lack of success with anti-EGFR therapy in the clinic. After generating a number of treatment resistant Glioblastoma cell lines they observed that resistant cell lines lacked EGFR activation and expression.
[Scientific Reports]
Areeb, Z., Stuart, S. F., West, A. J., Gomez, J., Nguyen, H. P. T., Paradiso, L., Zulkifli, A., Jones, J., Kaye, A. H., Morokoff, A. P., & Luwor, R. B. (2020). Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma. Scientific Reports, 10(1), 17768. https://doi.org/10.1038/s41598-020-74746-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

SMAR1 Repression by Pluripotency Factors and Consequent Chemoresistance in Breast Cancer Stem-Like Cells Is Reversed by Aspirin

Investigators found in breast tumors that the expression of SMAR1 was decreased in cancer stem cells through the cooperative interaction of the pluripotency factors Oct4 and Sox2 with the histone deacetylase HDAC1.
[Science SIgnaling]
SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin | Science Signaling. (n.d.). Retrieved October 20, 2020, from https://stke.sciencemag.org/content/13/654/eaay6077 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Severe Anemia Caused by Dominant Mutations in Krüppel-Like Factor 1 (KLF1)

The authors highlight recent molecular, biochemical, and genetic studies of KLF1 mutants, particularly the dramatic consequences that come from just a single amino acid change.
[Mutation Research-Reviews in Mutation Research]
Kulczynska-Figurny, K., Bieker, J. J., & Siatecka, M. (2020). Severe anemia caused by dominant mutations in Krüppel-like factor 1 (KLF1). Mutation Research/Reviews in Mutation Research, 108336. https://doi.org/10.1016/j.mrrev.2020.108336 Cite
Abstract
Bookmark

No account yet? Register

1+
Share
Share