Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

CCL18 Signaling from Tumor-Associated Macrophages Activates Fibroblasts to Adopt a Chemoresistance-Inducing Phenotype

[Oncogene] CCL18 secreted by tumor-associated macrophages activated a CD10+GPR77+ cancer-associated fibroblast (CAF) phenotype in normal breast-resident fibroblasts, enriching cancer stem cells and inducing chemoresistance in breast cancer cells.

Superenhancer-Activation of KLHDC8A Drives Glioma Ciliation and Hedgehog Signaling

[Journal of Clinical Investigation] Scientists interrogated superenhancer landscapes of primary glioblastoma specimens and patient-derived GSCs, revealing a kelch domain-containing gene (KLHDC8A) with a previously unknown function as an epigenetically-driven oncogene.

PTEN Overexpression and Nuclear β-Catenin Stabilization Promote Morular Differentiation through Induction of Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Properties in Endometrial Carcinoma

[Cell Communication and Signaling] Investigators found that PTEN overexpression and nuclear β-catenin stabilization promoted the establishment and maintenance of morular phenotype associated with epithelial–mesenchymal transition/CSC-like features in endometrial carcinoma cells.

Cell-Cell Contact-Driven EphB1 Cis- and Trans- Signalings Regulate Cancer Stem Cells Enrichment after Chemotherapy

[Cell Death & Disease] Investigators found that during the process of dormancy and reactivation induced by cisplatin, non-small cell lung cancer cells underwent sequential epithelial-to-mesenchymal transition-mesenchymal-to-epithelial transition with enrichment of CSCs.

Metformin Abrogates Fusobacterium nucleatum-Induced Chemoresistance in Colorectal Cancer by Inhibiting miR-361-5p/Sonic Hedgehog Signaling-Regulated Stemness

[British Journal of Cancer] Researchers investigated whether metformin could revert F. nucleatum-induced chemoresistance and explored the mechanism.

Mitophagy Bridges DNA Sensing With Metabolic Adaption To Expand Lung Cancer Stem-Like Cells

[EMBO Reports] The authors identified hypermitophagy as a feature of human lung CSCs, promoting metabolic adaption via the Notch1-AMPK axis to drive CSC expansion.

Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells Through Lead Optimization

[Journal of Medicinal Chemistry] In order to develop potent and selective CYP4Z1 inhibitors, a series of novel N-hydroxyphenylformamidines were rationally designed and synthesized from a pan-CYP inhibitor HET0016.

P2X1 Enhances Leukemogenesis Through PBX3-BCAT1 Pathways

[Leukemia] Scientists revealed that the metabolic niche component, ATP, efficiently induced ion influx in leukemia-initiating cells through its ligand-gated ion channel, P2X1.

Intravital Imaging To Study Cancer Progression and Metastasis

[Nature Reviews Cancer] The authors describe new techniques that allow access to a range of tissue and cancer types, novel fluorescent reporters and biosensors that allow fate mapping and the probing of functional and phenotypic states, and the clinical applications that have arisen.

UC Clermont Professor Receives $100,000 Grant for Cancer Research

[University of Cincinnati] A University of Cincinnati (UC) Clermont professor has received a $100,000 PhRMA Foundation Faculty Starter Grant in drug discovery for her work on new antibiotics capable of taking on cancer stem cells.

Implications of Cancer Stem Cells in Diabetes and Pancreatic Cancer

[Life Sciences] Investigators provide insight into the relationship between diabetes and pancreatic cancer and the methods that can be employed to diagnose this disease at an earlier stage successfully.

The Long Noncoding RNA TINCR Promotes Self-Renewal of Human Liver Cancer Stem Cells through Autophagy Activation

[Cell Death & Disease] TINCR was found to be highly expressed in HCC tissues and liver cancer stem cells (LCSCs). In vitro and in vivo assays for the first time showed that TINCR was required for LCSC self-renewal and tumorigenesis.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.