Autophagy Inhibition Reinforces Stemness Together with Exit from Dormancy of Polydisperse Glioblastoma Stem Cells

The authors silenced two autophagy related genes -either Beclin1 or ATG5- by shRNA and they explored the ensuing consequences on CSCs markers’ expression and functionalities.
[Aging-Us]
Aging | Autophagy inhibition reinforces stemness together with exit from dormancy of polydisperse glioblastoma stem cells - Full Text. (n.d.). Retrieved July 28, 2021, from https://www.aging-us.com/article/203362/text Cite
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Aspirin Enhances the Therapeutic Efficacy of Cisplatin in Oesophageal Squamous Cell Carcinoma by Inhibition of Putative Cancer Stem Cells

The authors investigated the role of acetylsalicylic acid in chemotherapy/chemoprevention in human oesophageal squamous cell carcinoma (ESCC) cell lines and an N-nitrosomethylbenzylamine-induced rat ESCC carcinogenesis model.
[British Journal of Cancer]
Zou, Z., Zheng, W., Fan, H., Deng, G., Lu, S.-H., Jiang, W., & Yu, X. (2021). Aspirin enhances the therapeutic efficacy of cisplatin in oesophageal squamous cell carcinoma by inhibition of putative cancer stem cells. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-021-01499-3 Cite
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Human Prostate Epithelial Cells and Prostate-Derived Stem Cells Malignantly Transformed In Vitro with Sodium Arsenite Show Impaired Toll Like Receptor -3 (TLR3)-Associated Anti-Tumor Pathway

Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.
[Toxicology Letters]
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Targeting Cancer Stem Cells in Medulloblastoma by Inhibiting AMBRA1 Dual Function in Autophagy and STAT3 Signaling

Investigators identified a previously unrecognized role of the pro-autophagy factor AMBRA1 in regulating medulloblastoma .
[Acta Neuropathologica]
Nazio, F., Po, A., Abballe, L., Ballabio, C., Diomedi Camassei, F., Bordi, M., Camera, A., Caruso, S., Caruana, I., Ferraina, C., Milletti, G., Gianesello, M., Reddel, S., De Luca, C. D., Ceglie, D., Marinelli, S., Campello, S., Papaleo, E., Miele, E., … Cecconi, F. (2021). Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling. Acta Neuropathologica. https://doi.org/10.1007/s00401-021-02347-7 Cite
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Catch Me If You Can: How AML and Its Niche Escape Immunotherapy

Researchers describe the immunological features of the acute myeloid leukemia (AML) niche, with particular attention to the crosstalk between the AML blasts and the cellular components of the altered tumor microenvironment and the mechanisms of immune escape that hamper the therapeutic effects of the most advanced treatments.
[Leukemia]
Tettamanti, S., Pievani, A., Biondi, A., Dotti, G., & Serafini, M. (2021). Catch me if you can: how AML and its niche escape immunotherapy. Leukemia, 1–10. https://doi.org/10.1038/s41375-021-01350-x Cite
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Elevated Cellular PpIX Potentiates Sonodynamic Therapy in a Mouse Glioma Stem Cell-Bearing Glioma Model by Downregulating the Akt/NF-κB/MDR1 Pathway

In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.
[Scientific Reports]
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State Gives $51 Million to College Students for Stem Cell Research

The California stem cell agency awarded $51 million to help train students in the art of research at the Golden State’s community colleges and universities.
[Capitol Weekly]
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Nuclear NAD+ Homeostasis Governed by NMNAT1 Prevents Apoptosis of Acute Myeloid Leukemia Stem Cells

Scientists demonstrated that NAD+ metabolism enabled acute myeloid leukemia (AML) to evade apoptosis. They integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis.
[Science Advances]
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Afatinib Induces Pro-Survival Autophagy and Increases Sensitivity to Apoptosis in Stem-Like HNSCC Cells

Scientists demonstrated that afatinib induced mTORC1 suppression-mediated autophagy in head and neck squamous cell carcinoma cells.
[Cell Death & Disease]
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Nicotinamide Phosphoribosyltransferase Inhibitors Selectively Induce Apoptosis of AML Stem Cells by Disrupting Lipid Homeostasis

Investigators performed a metabolic drug screen to identify leukemic stem cell (LSC)-specific vulnerabilities and found that nicotinamide phosphoribosyltransferase inhibitors selectively killed LSCs, while sparing normal hematopoietic stem and progenitor cells.
[Cell Stem Cell]
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Oblato Announces That It Has Received a Positive Response from the FDA for the Use of OKN-007 for Patients with High-grade Gliomas in an Expanded Access Program

Oblato, Inc. announced that it has received an agreement from the FDA for its plan to submit an intermediate size expanded access protocol for use of OKN-007 in patients with high-grade gliomas.
[Oblato, Inc.]
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