Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

RAB27B-Regulated Exosomes Mediate LSC Maintenance via Resistance to Senescence and Crosstalk with the Microenvironment

[Leukemia] Investigators found that increased RAB27B in leukemia stem cells prevented their senescence and maintained their stemness in vitro and in vivo.

The Promoting Effect and Mechanism of MAD2L2 on Stemness Maintenance and Malignant Progression in Glioma

[Journal of Translational Medicine] Scientists elucidated the role of Mitotic arrest deficient 2 like 2 (MAD2L2) in maintaining glioblastoma stemness and promoting malignant behaviors through the regulation of c-MYC.

Transcription Factor MITF Inhibits the Transcription of CPT1B to Regulate Fatty Acid ╬▓-Oxidation and Thus Affects Stemness in Lung Adenocarcinoma Cells

[Pharmacology] Transcription factor MITF inhibited transcription of CPT1B to regulate fatty acid ╬▓-oxidation, thereby suppressing stemness in lung adenocarcinoma cells.

Inhibition of Mitochondria Induces Apoptosis and Reduces Telomere Length and Activity in Acute Myeloid Leukemia Stem Cells

[Cell Biochemistry And Function] Investigators evaluated whether leukemia stem cells was influenced by mitochondrial inhibition.They demonstrated that the inhibition of mitochondrial activity by tigecycline affects CSCs in comparison with other cells.

Inhibiting NR5A2 Targets Stemness in Pancreatic Cancer by Disrupting SOX2/MYC Signaling and Restoring Chemosensitivity

[Journal of Experimental & Clinical Cancer Research] The authors elucidated the function of the nuclear receptor subfamily 5, group A, member 2 (NR5A2) in the context of pancreatic CSCs.

RCC2 Promotes Prostate Cancer Cell Proliferation and Migration through Hh/GLI1 Signaling Pathway and Cancer Stem-Like Cells

[Biology Direct] Researchers explored the function of regulator of chromosome condensation 2 (RCC2) on prostate cancer (PCa) development. They found that RCC2 promoted PCa development through Hh/Gli1 signaling pathway via regulating epithelial-mesenchymal transition and CSCs.

1-Benzylimidazole Attenuates the Stemness of Breast Cancer Cells through Partially Targeting CYP4Z1

[Environmental Toxicology] RNA sequencing found that 1-benzylimidazole held a preferable correlation with breast cancer and suppressed the expression of CSC makers.

TET1 Regulates Stem Cell Properties and Cell Cycle of Cancer Stem Cells in Triple-Negative Breast Cancer via DNA Demethylation

[Biochemical Pharmacology] Investigators revealed that TET1 could regulate the phenotype of CSCs via OCT4. Additionally, it could control the cell cycle by increasing CDK1 and CCNB1 levels.

Montefiore Einstein Comprehensive Cancer Center Awarded FDA Grant for Clinical Trial on Experimental AML/MDS Treatment

[Albert Einstein College of Medicine] Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center were awarded a four-year, $2.6 million grant from the US FDA to conduct an innovative Phase I clinical trial of a new drug for patients with relapsed and treatment-resistant forms of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).

ID1 Expressing Macrophages Support Cancer Cell Stemness and Limit CD8+ T Cell Infiltration in Colorectal Cancer

[Nature Communications] Researchers reported that high expression of inhibitor of differentiation 1 (ID1) in tumor-associated macrophages correlated with poor outcome in patients with colorectal cancer.

Sniping Cancer Stem Cells with Nanomaterials

[ACS Nano] Scientists provide an update on the current landscape of nanobased precision targeting approaches against CSCs. They elucidate the nuanced application of organic, inorganic, and bioinspired nanomaterials across a spectrum of therapeutic paradigms, encompassing targeted therapy, and more.

Predominant Factors Influencing Reactive Oxygen Species in Cancer Stem Cells

[Journal of Cellular Biochemistry] The authors summarize the mechanisms of redox regulation in CSCs, with a focus on therapy resistance, its various pathways and microRNAs regulation, and the potential therapeutic implications of manipulating the reactive oxygen species levels to eradicate CSCs.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.

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