Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Melanoma Stem Cells Promote Metastasis via Exosomal miR-1268a Inactivation of Autophagy

[Biological Research] Exosomes secreted by highly metastatic melanoma cancer stem cells promoted the invasiveness of the low metastatic melanoma cells and accelerated metastatic progression. miR-1268a was up-regulated in cells and exosomes of highly metastatic melanoma cancer stem cells.

TGFB2-AS1 Inhibits Triple-Negative Breast Cancer Progression via Interaction With SMARCA4 and Regulating Its Targets TGFB2 and SOX2

[Proceedings of the National Academy of Sciences of the United States of America] Investigators revealed that TGFB2-AS1 impaired the breast cancer stem-like cell traits of TNBC cells in vitro and dramatically decreases tumorigenic frequency and lung metastasis in vivo.

β-Escin Overcomes Trastuzumab Resistance in HER2-Positive Breast Cancer by Targeting Cancer Stem-Like Features

[Cancer Cell International] The effect of β-escin on trastuzumab-resistant and -sensitive cell lines in vitro was evaluated for apoptosis, expression of HER2 family members, and impact on cancer stem cell-like properties.

Loss of SNAI1 Induces Cellular Plasticity in Invasive Triple-Negative Breast Cancer Cells

[Cell Death & Disease] SNAI1 knockout cells exhibited plasticity in differentiation, drifting towards the luminal phenotype, gained stemness potential, and could differentiate into acinar mammospheres in 3D culture.

Oncofetal Protein IGF2BP1 Regulates IQGAP3 Expression To Maintain Stem Cell Potential in Cancer

[iScience] Scientists found that IGF2BP1 and IQGAP3 expression levels were highest in the blastocyst, with both decreasing during adulthood. This suggested that IQGAP3, like IGF2BP1, is an early developmental gene that is aberrantly upregulated upon re-expression of IGF2BP1 during carcinogenesis.

Radiochemotherapy-Induced DNA Repair Promotes the Biogenesis of Gastric Cancer Stem Cells

[Stem Cell Research & Therapy] RNA-seq was performed to identify which DNA repair genes were crucial for CSC traits induction, followed by the investigation of underlying mechanism and functional significance via in vitro and in vivo experiments.

A Calpain-6/YAP Axis in Sarcoma Stem Cells That Drives the Outgrowth of Tumors and Metastases

[Cell Death & Disease] Investigators used an osteosarcoma cell model, osteosarcoma tissues and transcriptomic data from human tumors to study gene patterns associated with calpain-6 expression or suppression.

β-Escin Overcomes Trastuzumab Resistance in HER2-Positive Breast Cancer by Targeting Cancer Stem-Like Features

[Cancer Cell International] The effect of β-escin on trastuzumab-resistant and -sensitive cell lines in vitro was evaluated for apoptosis, expression of HER2 family members, and impact on CSC-like properties.

A Primary Hierarchically Organized Patient-Derived Model Enables in Depth Interrogation of Stemness Driven by the Coding and Non-Coding Genome

[Leukemia] Through classical flow sorting and functional analyses, researchers established that a single phenotypic population was highly enriched for leukemic stem cells (LSC). The LSC fraction could be easily isolated and serially expanded in culture or in xenografts while faithfully recapitulating functional, transcriptional and epigenetic features of primary LSCs.

Direct Cell–Cell Interaction Regulates Division of Stem Cells From PC-3 Human Prostate Cancer Cell Line

[Biochemical and Biophysical Research Communications] Investigators found that the proliferation of PC-3-derived CSCs was significantly decreased in the presence of non-CSC-rich parental PC-3 cells compared with that in a culture in which they were absent.

FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A

[Stem Cells International] Investigators found that FBXW7 participated in the self-renewal, tumorigenicity, sorafenib therapy, and stem cell-like properties of hepatocellular carcinoma cells in vivo and in vitro.

The Genesis and Evolution of Acute Myeloid Leukemia Stem Cells in the Microenvironment: From Biology to Therapeutic Targeting

[Cell Death Discovery] Scientists discuss the relationship between leukeumic stem cells (LSCs), the bone marrow microenvironment, and how understanding the generation and evolution laws of LSCs can facilitate the development of effective therapeutic targets.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.

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