DCLK1, a Putative Novel Stem Cell Marker in Human Cholangiocarcinoma

Investigators evaluated in vitro the expression and the biological function of DCLK1 in intrahepatic cholangiocarcinom (CCA) and perihilar CCA.
[Hepatology]
Nevi, L., Matteo, S. D., Carpino, G., Zizzari, I., Safarikia, S., Ambrosino, V., Costantini, D., Overi, D., Giancotti, A., Monti, M., Bosco, D., Peppo, V. D., Oddi, A., Rose, A. M. D., Melandro, F., Bragazzi, M. C., Faccioli, J., Massironi, S., Grazi, G. L., … Alvaro, D. (n.d.). DCLK1, a putative novel stem cell marker in human cholangiocarcinoma. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31571 Cite
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ATR Is Essential for Preservation of Cell Mechanics and Nuclear Integrity during Interstitial Migration

ATR-defective cells were defective in neuronal migration during development and in metastatic dissemination from circulating tumor cells.
[Nature Communications]
Kidiyoor, G. R., Li, Q., Bastianello, G., Bruhn, C., Giovannetti, I., Mohamood, A., Beznoussenko, G. V., Mironov, A., Raab, M., Piel, M., Restuccia, U., Matafora, V., Bachi, A., Barozzi, S., Parazzoli, D., Frittoli, E., Palamidessi, A., Panciera, T., Piccolo, S., … Foiani, M. (2020). ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nature Communications, 11(1), 4828. https://doi.org/10.1038/s41467-020-18580-9 Cite
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Matrix Metalloprotease-7 Mediates Nucleolar Assembly & Intra-Nucleolar Cleaving p53 in Gefitinib Resistant Cancer Stem Cells

Investigators showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.
[iScience]
Yu, W.-H., Wu, E., Li, Y., Hou, H.-H., Yu, S. C., Huang, P.-T., Kuo, W.-H., Qi, D., & Yu, C.-J. (2020). Matrix metalloprotease-7 mediates nucleolar assembly & intra-nucleolar cleaving p53 in gefitinib resistant cancer stem cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101600 Cite
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The Role of Smoothened in Cancer

Smoothened (SMO) expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity.
[International Journal of Medical Sciences]
Jeng, K.-S., Sheen, I.-S., Leu, C.-M., Tseng, P.-H., & Chang, C.-F. (2020). The Role of Smoothened in Cancer. International Journal of Molecular Sciences, 21(18), 6863. https://doi.org/10.3390/ijms21186863 Cite
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The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors

The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses.
[Diagnostics ]
Ko, C. C. H., Chia, W. K., Selvarajah, G. T., Cheah, Y. K., Wong, Y. P., & Tan, G. C. (2020). The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors. Diagnostics, 10(9), 721. https://doi.org/10.3390/diagnostics10090721 Cite
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Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

The authors studied the contribution of nestin+ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
[Cell Metabolism]
Forte, D., García-Fernández, M., Sánchez-Aguilera, A., Stavropoulou, V., Fielding, C., Martín-Pérez, D., López, J. A., Costa, A. S. H., Tronci, L., Nikitopoulou, E., Barber, M., Gallipoli, P., Marando, L., Castillejo, C. L. F. de, Tzankov, A., Dietmann, S., Cavo, M., Catani, L., Curti, A., … Méndez-Ferrer, S. (2020). Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.09.001 Cite
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Quantitative In Vivo Bioluminescence Imaging of Orthotopic Patient-Derived Glioblastoma Xenografts

Scientists showed that stable expression of near-infrared fluorescent protein in patient-derived glioblastoma cells enabled rapid, direct non-invasive monitoring of tumor development without compromising tumor stemness or tumorigenicity.
[Scientific Reports]
Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N., Chalmers, A. J., Norman, J. C., & Tait, S. W. G. (2020). Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10(1), 15361. https://doi.org/10.1038/s41598-020-72322-x Cite
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A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity

Investigators described the chemical synthesis and biological activity of a new doxycycline derivative, designed specifically to more effectively target CSCs.
[Frontiers in Oncology]
Ózsvári, B., Magalhães, L. G., Latimer, J., Kangasmetsa, J., Sotgia, F., & Lisanti, M. P. (2020). A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity. Frontiers in Oncology, 10. https://doi.org/10.3389/fonc.2020.01528 Cite
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SPT6-Driven Error-Free DNA Repair Safeguards Genomic Stability of Glioblastoma Cancer Stem-Like Cells

Researchers presented the results of a high-content siRNA microscopy screen, revealing the transcriptional elongation factor SPT6 to be critical for the genomic stability and self-renewal of glioblastoma cancer-stem like cells.
[Nature Communications]
Obara, E. A. A., Aguilar-Morante, D., Rasmussen, R. D., Frias, A., Vitting-Serup, K., Lim, Y. C., Elbæk, K. J., Pedersen, H., Vardouli, L., Jensen, K. E., Skjoth-Rasmussen, J., Brennum, J., Tuckova, L., Strauss, R., Dinant, C., Bartek, J., & Hamerlik, P. (2020). SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells. Nature Communications, 11(1), 4709. https://doi.org/10.1038/s41467-020-18549-8 Cite
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Immunomedics Announces Encouraging Early-Stage Clinical Results with Trodelvy in Brain Cancers

Immunomedics, Inc.announced that Trodelvy delivered 150-fold and 40-fold the 50% inhibitory concentration of SN-38 for brain metastasis from breast cancer and recurrent glioblastoma, respectively, and produced partial responses in both cohorts of brain cancer patients.
[Immunomedics, Inc.]
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NIH Funds Research into Differences in Glioblastoma between Males and Females

A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic’s Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females.
[Cleveland Clinic Lerner Research Institute]
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