In vitro infection of the T24 cell line with E. coli was performed to study the bacterial impact on bladder cancer cells. EMT markers were assessed using immunohistochemistry, western blot and RT-PCR. Stemness characteristics were monitored using RT-PCR.
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Abd-El-Raouf, R., Ouf, S. A., Gabr, M. M., Zakaria, M. M., El-Yasergy, K. F., & Ali-El-Dein, B. (2020). Escherichia coli foster bladder cancer cell line progression via epithelial mesenchymal transition, stemness and metabolic reprogramming. Scientific Reports, 10(1), 18024. https://doi.org/10.1038/s41598-020-74390-5 Cite
Researchers found that glioblastoma multiforme-cerebrospinal fluid-exosomes (GBM-CSF-Exos) contained a unique protein, LGALS9 ligand, which bound to the TIM3 receptor of dendritic cells (DCs) in the CSF to inhibit antigen recognition, processing and presentation by DCs, leading to failure of the cytotoxic T-cell-mediated antitumor immune response.
[Cell Death & Disease]
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In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
[Cell Death & Disease]
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Yang, W.-J., Sun, Y.-F., Jin, A.-L., Lv, L.-H., Zhu, J., Wang, B.-L., Zhou, Y., Zhang, C.-Y., Wang, H., Hu, B., Wang, P.-X., Te, L., Pan, B.-S., Zhou, J., Fan, J., Yang, X.-R., & Guo, W. (2020). BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity. Cell Death & Disease, 11(10), 1–13. https://doi.org/10.1038/s41419-020-03115-3 Cite
TRIM28 high level related to higher melanoma stemness as measured with several distinct scores and TRIM28HIGH-expressing melanoma cell lines possess the greater potential of melanosphere formation.
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Agios Pharmaceuticals, Inc. announced the withdrawal of its European Marketing Authorization Application for TIBSOVO® for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-1 mutation.
[Agios Pharmaceuticals, Inc]
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The authors focus on the contribution of chromosome instability studies to genetic heterogeneity in circulating tumor cells (CTCs) at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine.
Researchers crossed the MMTV‐PyMT model of mammary gland tumorigenesis with a TgfbiΔ/Δ mouse, and studied the cancer stem cell (CSC) content of the tumors. They performed RNAseq on WT and KO tumours, and analyzed the tumor vasculature and the immune compartment by IHC and FACS.
Scientists compared the effects of three tissue‐derived mesenchynal stem cells (MSCs) in vivo on colon tumor xenograft growth. Then, they analyzed the tropism of bone marrow‐derived MSCs toward normal intestinal epithelial cells, parental colon cancer cells, CD133−/CD44−, and CD133+/CD44+ colon cancer cells in vitro.
[Journal of Cellular Physiology]
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Ma, X., Chen, J., Liu, J., Xu, B., Liang, X., Yang, X., Feng, Y., Liang, X., & Liu, J. (n.d.). IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+/CD44+ Colon cancer stem cells. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30080 Cite
Researchers explored the underlying mechanisms behind treatment resistance and the lack of success with anti-EGFR therapy in the clinic. After generating a number of treatment resistant Glioblastoma cell lines they observed that resistant cell lines lacked EGFR activation and expression.
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Areeb, Z., Stuart, S. F., West, A. J., Gomez, J., Nguyen, H. P. T., Paradiso, L., Zulkifli, A., Jones, J., Kaye, A. H., Morokoff, A. P., & Luwor, R. B. (2020). Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma. Scientific Reports, 10(1), 17768. https://doi.org/10.1038/s41598-020-74746-x Cite
Investigators found in breast tumors that the expression of SMAR1 was decreased in cancer stem cells through the cooperative interaction of the pluripotency factors Oct4 and Sox2 with the histone deacetylase HDAC1.
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SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin | Science Signaling. (n.d.). Retrieved October 20, 2020, from https://stke.sciencemag.org/content/13/654/eaay6077 Cite
The authors highlight recent molecular, biochemical, and genetic studies of KLF1 mutants, particularly the dramatic consequences that come from just a single amino acid change.
[Mutation Research-Reviews in Mutation Research]