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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Nivolumab in Patients with Metastatic Castration-Resistant Prostate Cancer with and without DNA Repair Defects
[Clinical Cancer Research] Scientists conducted a Phase II, multi-center, single-arm trial evaluating nivolumab in post-docetaxel metastatic castration-resistant prostate cancer patients. DNA repair defects was assessed using circulating tumor DNA.
Clinical Cancer Research in the US Increasingly Dominated by Pharmaceutical Industry Sponsors
[Fred Hutch] Researchers at Fred Hutch Cancer Center identified a substantial increase over the past decade in the proportion of patients with cancer in the US who participate in pharmaceutical industry sponsored clinical trials compared to those conducted with federal government support.
New Funding for Brain Cancer Research at UCL
[UCL] The announcement will support the Cancer Research UK Glioma Brain Tumor Centre of Excellence, a collaboration between UCL and the University of Edinburgh, whose work aims to better understand the disease and find new treatments.
A Live Single-Cell Reporter System Reveals Drug-Induced Plasticity of a Cancer Stem Cell-Like Population in Cholangiocarcinoma
[Scientific Reports] Since dual expression of the core pluripotent factors SOX2/OCT4 has been shown to correlate with poor outcome in cholangiocarcinoma patients, researchers selected the SOX2/OCT4 activating short half-life GFP-based live reporter to study CSC dynamics at the single-cell level.
Integration of Single-Cell Sequencing and Bulk Transcriptome Data Develops Prognostic Markers Based on PCLAF+ Stem-Like Tumor Cells Using Artificial Neural Network in Gastric Cancer
[Heliyon] Stem-like tumor cells were identified by mining single-cell transcriptomic data from multiple samples. Integrated analysis of single-cell and bulk transcriptome data was performed to analyze the role of stem-like tumor cells in predicting clinical outcomes by introducing the intermediate variable mRNA stemness degree.
An ILK/STAT3 Pathway Controls Glioblastoma Stem Cell Plasticity
[Developmental Cell] Investigators showed that the extracellular matrix-cell adhesion protein integrin-linked kinase (ILK) stimulated phenotypic plasticity and mesenchymal-like, invasive behavior in a murine glioblastoma stem cell model.
Targeting CREB-Binding Protein (CBP) Abrogates Colorectal Cancer Stemness through Epigenetic Regulation of C-MYC
[Cancer Gene Therapy] Investigators converted hiPSCs into cancer stem-like cells by culture with conditioned medium from colorectal cancer cells. These transformed cells, termed hiPSC-CSCs, displayed cancer stem-like properties, including a spheroid morphology and the expression of both pluripotency and CSC markers.
Aneuploidy as a Driver of Human Cancer
[Nature Genetics] The authors delved into the context-dependent identification and functional characterization of the driver genes underlying driver aneuploidies and examine emerging strategies to uncover these driver genes using cancer genomics data and cancer models.
Cellular Taxonomy of the Preleukemic Bone Marrow Niche of Acute Myeloid Leukemia
[Leukemia] Using our AML-murine model, researchers performed single-cell RNA-sequencing of preleukemic BMM cells. They found normal HSC-regulating LepR+ mesenchymal stem cells, and endothelial cells were decreased, along with increases in CD55+ fibroblasts and pericytes.
RNA m5C Oxidation by TET2 Regulates Chromatin State and Leukaemogenesis
[Nature] Investigators showed that chromatin-associated retrotransposon RNA 5-methylcytosine (m5C) can be recognized by the methyl-CpG-binding-domain protein MBD6, which guided deubiquitination of nearby monoubiquitinated Lys119 of histone H2A to promote an open chromatin state.
Combinations of HDAC Inhibitor and PPAR Agonist Induce Ferroptosis of Leukemic Stem Cell-Like Cells in Acute Myeloid Leukemia
[Clinical Cancer Research] Leukemia stem cell-like cell lines, CD34+ primary AML cells purified from AML patients treated with CS055 and/or chiglitazar and were analyzed for viability, death, and colony formation assay.
Interleukin-34-Orchestrated Tumor-Associated Macrophage Reprogramming Is Required for Tumor Immune Escape Driven by p53 Inactivation
[Immunity] Scientists found that CSCs established an interleukin-34-orchestrated niche to promote tumorigenesis in p53-inactivated liver cancer.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
