The authors describe the circuitry of a transactivation system responsible for oncogenic self-renewal. MLL recruited RNA polymerase II to unmethylated CpG-rich promoters by its CXXC domain and activated transcription by transcriptional regulators, including the AF4 family/ENL family/P-TEFb complex, DOT1L, and p300/CBP histone acetyl transferases.
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Investigators found that pancreatic ductal adenocarcinomas overexpressed the myelin regulatory factor, an ER membrane-associated transcription factor released by self-cleavage.
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Milan, M., Balestrieri, C., Alfarano, G., Polletti, S., Prosperini, E., Nicoli, P., Spaggiari, P., Zerbi, A., Cirulli, V., Diaferia, G. R., & Natoli, G. (2020). Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.09.011 Cite
The arginine methyltransferase PRMT5 can methylate lymphoid-specific helicase (LSH) at R309 residue, meanwhile, LSH could as well be phosphorylated by MAPK1 kinase at S503 residue.
[Signal Transduction and Targeted Therapy]
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Liu, N., Yang, R., Shi, Y., Chen, L., Liu, Y., Wang, Z., Liu, S., Ouyang, L., Wang, H., Lai, W., Mao, C., Wang, M., Cheng, Y., Liu, S., Wang, X., Zhou, H., Cao, Y., Xiao, D., & Tao, Y. (2020). The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties. Signal Transduction and Targeted Therapy, 5(1), 1–14. https://doi.org/10.1038/s41392-020-00249-w Cite
Prelude Therapeutics Incorporated announced that the first patient has been dosed in its first-in-human Phase I open-label, multicenter, dose-escalation study of PRT1419 in patients with relapsed/refractory hematologic malignancies. PRT1419, the company’s third clinical candidate, is designed to be an orally available, potent and selective MCL1 inhibitor.
[ Prelude Therapeutics Incorporated ]
Apollomics, Inc., announced APL-106 has received Investigational New Drug approval from the China National Medical Products Administration Center for Drug Evaluation. This approval enables the initiation of a Phase I pharmacokinetic and tolerability study and includes acceptance of a Phase III bridging study of APL-106 in combination with chemotherapy in relapsed/refractory acute myeloid leukemia.
Basilea Pharmaceutica Ltd. announced that it has initiated a Phase II expansion study with its tumor checkpoint controller, lisavanbulin, in patients with recurrent glioblastoma multiforme, whose tumor has tested positive for the potential response-predictive biomarker end-binding protein 1.
[Basilea Pharmaceutica Ltd. ]
Human induced pluripotent stem cells were converted into cancer stem cells (CSCs) in the presence of conditioned medium from PK8 cells. CSCs were then transplanted in vivo and formed primary tumors.
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Effects of degradable magnesium on paracrine signaling between human umbilical cord perivascular cells and peripheral blood mononuclear cells - Biomaterials Science (RSC Publishing). (n.d.). Retrieved September 30, 2020, from https://pubs.rsc.org/en/content/articlelanding/2020/BM/D0BM00834F#!divAbstract Cite
This study displayed histological and immunohistochemical analyses of a malignant tumor model developed from cancer stem cells converted from human iPSCs in a cancer microenvironment prepared from the conditioned medium of a pancreatic cancer cell line.
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The authors provide evidence on the functional role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas and discuss the benefits of its targeting as a novel approach toward glioma treatment.
[Journal of Molecular Medicine-Jmm]
Researchers collected the gene expression profiles of ovarian (O)CSCs were from five public cohorts and employed R software and Bioconductor packages to establish differently expressed genes between OCSCs and parental cells.
[Journal of Ovarian Research]
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Zhang, X., Su, Y., Wu, X., Xiao, R., Wu, Y., Yang, B., Wang, Z., Guo, L., Kang, X., & Wang, C. (2020). Integrative analysis of the common genetic characteristics in ovarian cancer stem cells sorted by multiple approaches. Journal of Ovarian Research, 13(1), 116. https://doi.org/10.1186/s13048-020-00715-7 Cite
Methanol extracts of carrot root were purified by means of silica gel, Sephadex LH-20, and preparative high-performance liquid chromatography to isolate a compound targeting mammosphere formation.
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