Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

CKS1 Inhibition Depletes Leukemic Stem Cells and Protects Healthy Hematopoietic Stem Cells in Acute Myeloid Leukemia

[Science Translational Medicine] Researchers studied the role of cyclin-dependent kinase regulatory subunit 1 (CKS1)–dependent protein degradation in primary human acute myeloid leukemia and healthy hematopoiesis xenograft models in vivo.

Exploring Stem Cell Biology in Pituitary Tumors and Derived Organoids

[Endocrine-Related Cancer] In human pituitary tumors, cells typified by expression of stemness markers, in particular SOX2 and SOX9, were found present in a wide variety of clinical tumor types, also showing a pronounced proliferative status.

Oct4A Palmitoylation Modulates Tumorigenicity and Stemness in Human Glioblastoma Cells

[Neuro-Oncology] The expression of Oct4 variants was evaluated in brain cancer cell lines, and in brain tumor tissues, by quantitative real-time PCR, western blotting, and immunohistochemical analysis.

The Presentation and Regulation of the IL-8 Network in the Epithelial Cancer Stem-Like Cell Niche in Patients with Colorectal Cancer

[Biomedicine & Pharmacotherapy] Scientists characterized the presentation of CSCs and the interleukin-8 network in the adenoma/colorectal cancer epithelium using quantitative real-time PCR, immunohistochemistry and double immunofluorescence.

Tumor-Associated Macrophages Promote Epithelial–Mesenchymal Transition and the Cancer Stem Cell Properties in Triple-Negative Breast Cancer through CCL2/AKT/β-Catenin Signaling

[Cell Communication and Signaling] Expression of the M2-like macrophage marker CD163 was evaluated by immunohistochemistry in human breast cancer tissues.

Single-Cell Analyses Define a Continuum of Cell State and Composition Changes in the Malignant Transformation of Polyps to Colorectal Cancer

[Nature Genetics] A large fraction of polyp and colorectal cancer (CRC) cells exhibited a stem-like phenotype, and investigators defined a continuum of epigenetic and transcriptional changes occurring in these stem-like cells as they progressed from homeostasis to CRC.

EZH2 Endorses Cell Plasticity to Non-Small Cell Lung Cancer Cells Facilitating Mesenchymal to Epithelial Transition and Tumor Colonization

[Oncogene] The authors found that besides its described role in CDKN2A-dependent cell proliferation, EZH2 upheld the epithelial state of cancer cells by repressing the transcription of hundreds of mesenchymal genes.

Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells

[Pathobiology] Tryptophan 2,3-dioxygenase (TDO2) expression was correlated with both progressive disease and clinical outcome, and its expression was an independent predictor of prognosis in GC.

Phenazine Derivatives Attenuate the Stemness of Breast Cancer Cells through Triggering Ferroptosis

[Cellular and Molecular Life Sciences] Scientists focused on the compounds without affecting cell viability and screened out three potential compounds that could significantly attenuate the stemness of breast cancer cells, as evident by the decrease of stemness marker expression.

circFCHO2 Promotes Gastric Cancer Progression by Activating the JAK1/STAT3 Pathway via Sponging miR-194-5p

[Cell Cycle] Cell counting kit-8 assay, 5-ethynyl-2-deoxyuridine staining, transwell experiment, tube formation and sphere formation experiments were applied to detect gastric cancer cell proliferation, invasion, angiogenesis and cancer stem cell characteristics.

CRISPR Screening in Cancer Stem Cells

[Essays in Biochemistry] Investigators discuss the progress made and emerging opportunities of coupling advanced CRISPR screening systems with CSC models to reveal the understudied vulnerabilities of CSCs.

The Cancer Grand Challenges Program Awards $100 Million To Four Research Teams

[Forbes] The National Cancer Institute, part of the National Institutes of Health, announced that four international research teams had been selected to receive a total of $100 million as part of the Cancer Grand Challenges program.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.

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