Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Dynamic Molecular Network Analysis of iPSC-Purkinje Cells Differentiation Delineates Roles of ISG15 in SCA1 at the Earliest Stage

[Communications Biology] The authors investigated the earliest molecular pathology of spinocerebellar ataxia type 1 (SCA1), a rare familial neurodegenerative disease that primarily induces death and dysfunction of cerebellum Purkinje cells.

SBU Senior Nishtha Tripathi to Be Inducted Into Competitive ASBMB Honor Society

[At Bonaventure University] St. Bonaventure University senior Nishtha Tripathi of Austin, Texas, is among 31 undergraduate students nationwide who were accepted into the competitive American Society for Biochemistry and Molecular Biology Honor Society for 2024.

IFI35 Regulates Non-Canonical NF-κB Signaling to Maintain Glioblastoma Stem Cells and Recruit Tumor-Associated Macrophages

[Cell Death & Differentiation] Scientists identified that IFI35, a transcriptional regulatory factor, played both cell-intrinsic and cell-extrinsic roles in maintaining glioma stem cells and the immunosuppressive tumor microenviroment.

Circulating Tumor Cells Shielded with Extracellular Vesicle-Derived CD45 Evade T Cell Attack to Enable Metastasis

[Signal Transduction And Targeted Therapy] The authors unequivocally identified a subpopulation of circulating tumor cells (CTCs) shielded with extracellular vesicle-derived CD45 that resisted T cell attack. A higher percentage of CD45+ CTCs was found to be closely correlated with higher incidence of metastasis and worse prognosis in cancer patients.

Loss of Stress Sensor GADD45A Promotes Stem Cell Activity and Ferroptosis Resistance in LGR4/HOXA9-Dependent AML

[Blood] Researchers defined GADD45A as a key downstream target of LGR4 oncogenic signaling and discover a regulatory role for GADD45A loss in promoting leukemia-initiating activity and oxidative resistance in LGR4/HOXA9-dependent AML, a poor prognosis subset of leukemia.

A Molecular Voyage: Multiomics Insights Into Circulating Tumor Cells

[Academic Pediatrics] Investigators review how state-of-the-art multiomics applied to circulating tumor cells (CTCs) are shedding light on how cancer spreads. They highlight the potential implications of CTC profiling for clinical applications aimed at enhancing cancer diagnosis and treatment.

YTHDF1 Promotes the Viability and Self-Renewal of Glioma Stem Cells by Enhancing LINC00900 Stability

[International Journal Of Oncology] Researchers investigated the molecular mechanism underlying the regulatory effects of YTHDF1 on the viability, invasion and self‑renewal of glioma stem cells.

Uracil- and Pyridine-Containing HDAC Inhibitors Displayed Cytotoxicity in Colorectal and Glioblastoma Cancer Stem Cells

[ChemMedChem] Seven HDACi, showing either hydroxamate or 2'-aminoanilide function, were tested in colorectal cancer and glioblastoma multiforme CSCs to determine their effects on cell proliferation, H3 acetylation levels and in-cell HDAC activity.

Involvement of TGFBI-TAGLN Axis in Cancer Stem Cell Property of Head and Neck Squamous Cell Carcinoma

[Scientific Reports] Through RNA-sequencing data from the TCGA database, we validated that increased TGFBI expression correlated with a higher occurrence of lymph node metastasis and unfavorable prognosis in HNSCC cases.

Transcriptional Regulation of Cancer Stem Cell: Regulatory Factors Elucidation and Cancer Treatment Strategies

[Journal Of Experimental & Clinical Cancer Research] Investigators comprehensively review the traditional aspects of transcriptional regulation, and explores the progress and insights of the impact on CSC transcription and status through tumor microenvironment, hypoxia, metabolism and new meaningful regulatory factors in conjunction with the latest research.

Hypoxia Drives Shared and Distinct Transcriptomic Changes in Two Invasive Glioma Stem Cell Lines

[Scientific Reports] Investigators surveyed eight patient-derived glioblastoma (GBM) stem cell lines for invasion phenotypes in 3D culture, which identified two GBM lines showing increased invasiveness in response to hypoxia.

Chronic Hypoxia Remodels the Tumor Microenvironment to Support Glioma Stem Cell Growth

[Acta Neuropathologica Communications] Researchers describe long-term cerebral organoids (COs) co-cultured with patient derived glioma stem cells (GSCs), a novel model in which COs were grown from embryonic stem cell cultures containing low levels of GSCs and tumor development wasmonitored over extended durations

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.