A Tumor-Resident Lgr5+ Stem-Cell-Like Pool Drives the Establishment and Progression of Advanced Gastric Cancers

Scientists showed that Cldn18 tumors accurately recapitulated advanced human gastric cancer in terms of disease morphology, aberrant gene expression, molecular markers and sites of distant metastases.
[Nature Cell Biology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Targeting the Metabolism of Cancer Stem Cells by Energy Disruptor Molecules

Investigators highlight the differences between regular cancer cells and CSC metabolism and discuss the action mechanisms of energy disruptors at the cellular and molecular levels.
[Critical Reviews in Oncology/Hematology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Advances in Glioma-Associated Oncogene (GLI) Inhibitors for Cancer Therapy

The authors review direct and indirect inhibitors of glioma-associated oncogene homolog (GLI); summarize the abundant active structurally diverse natural GLI inhibitors.
[Investigational New Drugs]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Elevated ATGL in Colon Cancer Cells and Cancer Stem Cells Promotes Metabolic and Tumorigenic Reprogramming Reinforced by Obesity

Elevated ATGL levels in human colon cancer cells relative to non-transformed were augmented by an obesity mediator, oleic acid.
[Oncogenesis]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Chemotoxicity-Induced Exosomal lncFERO Regulates Ferroptosis and Stemness in Gastric Cancer Stem Cells

Sphere-formation assay was used to estimate the stemness of gastric cancer stem cells. Exosomal lnc-ENDOG-1:1 (lncFERO) was isolated by ultracentrifugation.
[Cell Death & Disease]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Aptamer-Mediated Doxorubicin Delivery Reduces HCC Burden in 3D Organoids Model

Investigators developed a specific aptamer against EpCAM and tested its potential as a drug delivery agent for hepatocellular carcinoma.
[Journal of Controlled Release]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

pERK-Mediated IL8 Secretion Can Enhance the Migration, Invasion, and Cisplatin Resistance of CD10-Positive Oral Cancer Cells

Researchers hypothesized that IL8 might regulate migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells through the ERK pathway.
[BMC Cancer]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

NIR Irradiation Enhances the Apoptotic Potentiality of Quinacrine-Gold Hybrid Nanoparticles by Modulation of HSP-70 in Oral Cancer Stem Cells

Using in vitro oral squamous cell carcinoma CSCs and in vivo xenograft mice model, investigators systematically studied the apoptotic potentiality of Quinacrine-gold hybrid nanoparticle and its underlying mechanism after NIR irradiation.
[Nanomedicine-Nanotechnology Biology and Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Targeting alpha2,3-Sialylated Glycan in Glioma Stem-Like Cells by Maackia amurensis Lectin-II: A Promising Strategy for Glioma Treatment

The authors established a new glioma stem-like cell, named U373-GSC, from the U373 glioma cell line. The cells exhibited stemness properties, e.g., expression of stem cell markers, self-renewal activity, multi-lineage differentiating abilities, and drug resistance.
[Experimental Cell Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

MiR-342-3p Inhibits LCSC Oncogenicity and Cell Stemness through HDAC7/PTEN Axis

miR-342-3p overexpression in LCSC lead to lower tumor volume, reduced tumor spheroid formation and agar colony formation rates, as well as lower mRNA and protein expressions of CD44, ALDH1, Bmi1, Sox2, and Oct4.
[Inflammation Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Spatial Heterogeneity of Invading Glioblastoma Cells Regulated by Paracrine Factors

Scientists observed spatially heterogeneous GBM cell populations emerged from an isogenic clonal population of glioma-initiating cells during invasion into a 3D collagen hydrogel in a microfluidic device.
[Tissue Engineering Part A]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share