The authors provide evidence on the functional role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas and discuss the benefits of its targeting as a novel approach toward glioma treatment.
[Journal of Molecular Medicine-Jmm]
Researchers collected the gene expression profiles of ovarian (O)CSCs were from five public cohorts and employed R software and Bioconductor packages to establish differently expressed genes between OCSCs and parental cells.
[Journal of Ovarian Research]
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Zhang, X., Su, Y., Wu, X., Xiao, R., Wu, Y., Yang, B., Wang, Z., Guo, L., Kang, X., & Wang, C. (2020). Integrative analysis of the common genetic characteristics in ovarian cancer stem cells sorted by multiple approaches. Journal of Ovarian Research, 13(1), 116. https://doi.org/10.1186/s13048-020-00715-7 Cite
Methanol extracts of carrot root were purified by means of silica gel, Sephadex LH-20, and preparative high-performance liquid chromatography to isolate a compound targeting mammosphere formation.
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Scientists performed BSH-polyR-based boron neutron capture therapy (BNCT) against glioma stem-like cells and revealed that BSH-polyR successfully induced BNCT-dependent cell death specifically in CD44High cells.
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Fujimura, A., Yasui, S., Igawa, K., Ueda, A., Watanabe, K., Hanafusa, T., Ichikawa, Y., Yoshihashi, S., Tsuchida, K., Kamiya, A., & Furuya, S. (2020). In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy. Cells, 9(10), 2149. https://doi.org/10.3390/cells9102149 Cite
Knockdown of S100A10 in breast cancer cells suppressed and overexpression of S100A10 in breast cancer patient‐derived tumor xenograft cells enhanced their invasion abilities and 3D organoid formation capacities in vitro.
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Yanagi, H., Watanabe, T., Nishimura, T., Hayashi, T., Kono, S., Tsuchida, H., Hirata, M., Kijima, Y., Takao, S., Okada, S., Suzuki, M., Imaizumi, K., Kawada, K., Minami, H., Gotoh, N., & Shimono, Y. (n.d.). Upregulation of S100A10 in metastasized breast cancer stem cells. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14659 Cite
Investigators evaluated in vitro the expression and the biological function of DCLK1 in intrahepatic cholangiocarcinom (CCA) and perihilar CCA.
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Nevi, L., Matteo, S. D., Carpino, G., Zizzari, I., Safarikia, S., Ambrosino, V., Costantini, D., Overi, D., Giancotti, A., Monti, M., Bosco, D., Peppo, V. D., Oddi, A., Rose, A. M. D., Melandro, F., Bragazzi, M. C., Faccioli, J., Massironi, S., Grazi, G. L., … Alvaro, D. (n.d.). DCLK1, a putative novel stem cell marker in human cholangiocarcinoma. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31571 Cite
ATR-defective cells were defective in neuronal migration during development and in metastatic dissemination from circulating tumor cells.
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Kidiyoor, G. R., Li, Q., Bastianello, G., Bruhn, C., Giovannetti, I., Mohamood, A., Beznoussenko, G. V., Mironov, A., Raab, M., Piel, M., Restuccia, U., Matafora, V., Bachi, A., Barozzi, S., Parazzoli, D., Frittoli, E., Palamidessi, A., Panciera, T., Piccolo, S., … Foiani, M. (2020). ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nature Communications, 11(1), 4828. https://doi.org/10.1038/s41467-020-18580-9 Cite
Investigators showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.
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Smoothened (SMO) expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity.
[International Journal of Medical Sciences]
The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses.
The authors studied the contribution of nestin+ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
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Forte, D., García-Fernández, M., Sánchez-Aguilera, A., Stavropoulou, V., Fielding, C., Martín-Pérez, D., López, J. A., Costa, A. S. H., Tronci, L., Nikitopoulou, E., Barber, M., Gallipoli, P., Marando, L., Castillejo, C. L. F. de, Tzankov, A., Dietmann, S., Cavo, M., Catani, L., Curti, A., … Méndez-Ferrer, S. (2020). Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.09.001 Cite