KRT13 Promotes Stemness and Drives Metastasis in Breast Cancer through a Plakoglobin/C-myc Signaling Pathway

Keratin 13 (KRT13) plays an important role in breast cancer progression and metastasis. Researchers elucidated the mechanism by which KRTs promoted breast cancer growth and metastasis.
[Breast Cancer Research]
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Lyell Immunopharma Announces FDA Clearance of IND for LYL132, a T-cell Receptor Therapy for Solid Tumors Being Developed in Collaboration with GSK

Lyell Immunopharma, Inc. announced that US FDA has cleared an Investigational New Drug (IND) application to initiate a Phase I clinical trial for LYL132, an investigational T-cell receptor therapy for patients with solid tumors expressing New York esophageal squamous cell carcinoma 1 that the company is developing in collaboration with GSK.
[Lyell Immunopharma, Inc. (Globenewswire, Inc.)]
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Different Pancreatic Cancer Microenvironments Convert iPSCs into Cancer Stem Cells Exhibiting Distinct Plasticity with Altered Gene Expression of Metabolic Pathways

The isolated cells were characterized for cancer stem cell characters in vitro and in vivo as well as their responses to anticancer drugs.
[Journal of Experimental & Clinical Cancer Research]
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Deregulation of the CD44-NANOG-MDR1 Associated Chemoresistance Pathways of Breast Cancer Stem Cells Potentiates the Anti-cancer Effect of Kaempferol in Synergism with Verapamil

Researchers used Kaempferol in combination with Verapamil, in multiple assays to determine if there was an inhibitory effect on breast cancer stem cells.
[Toxicology and Applied Pharmacology]
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SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth

Downregulation of SET-domain containing 5 (SETD5) significantly decreased breast cancer stem-like cells properties and glycolysis in vitro and in vivo.
[American Journal of Pathology]
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Tumor Radioresistance Caused by Radiation-Induced Changes of Stem-Like Cell Content and Sub-lethal Damage Repair Capability

Four types of human oral squamous carcinoma cell lines, non-radioresistant cell lines, and radioresistant cell lines, were used to measure the surviving fraction after single-dose irradiation, split-dose irradiation, and multi-fractionated irradiation.
[Scientific Reports]
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Estrogen Receptor Beta Increases Clear Cell Renal Cell Carcinoma Stem Cell Phenotype via Altering the circPHACTR4/miR-34b-5p/C-myc Signaling

Scientists found estrogen receptor beta could increase the CSC population via altering the circPHACTR4/miR-34b-5p/c-Myc signaling.
[FASEB Journal]
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FOXM1 Mediates GDF-15 Dependent Stemness and Intrinsic Drug Resistance in Breast Cancer

The expressions and interactions of GDF-15, FOXM1, and stemness (OCT4 and SOX2), and drug resistance (ABCC5) markers were evaluated in breast cancer.
[Molecular Biology Reports]
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Tanshinone IIA Attenuates the Stemness of Breast Cancer Cells via Targeting the miR-125b/STARD13 Axis

In vitro mammary spheroid formation, flow cytometry assay on CD24−/CD44+ sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells.
[Experimental Hematology & Oncology]
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The Association between Bromodomain (BrD) Proteins and Cancer Stemness in Different Solid Tumor Types

Researchers demonstrated that significant upregulation of ATAD2 and SMARCA4, and downregulation of SMARCA2 was consistently associated with enriched cancer stem cell-like phenotype, respectively.
[International Journal of Cancer]
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RICH1 Inhibits Breast Cancer Stem Cell Traits through Activating Kinases Cascade of Hippo Signaling by Competing with Merlin for Binding to Amot-p80

Scientists found that the low expression of RICH1 in breast cancer was associated with poor prognosis. Depletion of RICH1 promoted the stemness and disrupted the normal epithelial architecture of MCF10A cells.
[Cell Death & Disease]
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