Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

SCARB2 Drives Hepatocellular Carcinoma Tumor Initiating Cells via Enhanced MYC Transcriptional Activity

[Nature Communications] Scientists performed a metabolic gene CRISPR/Cas9 knockout library screen in tumorspheres derived from HCC cells and found that deletion of scavenger receptor class B member 2 (SCARB2) suppressed the cancer stem cell-like properties of HCC cells.

LncRNA Tug1 Relieves the Steatosis of SelenoF-Knockout Hepatocytes via Sponging miR-1934-3p

[Cell Biology And Toxicology] The authors uncovered that the potent non-coding RNA Tug1, which was related to metabolic enzymes, regulated hepatocytes steatosis induced by sodium palmitate via miR-1934-3p absorbing.

Doxorubicin-Induced Senescence Promotes Resistance to Cell Death by Modulating Genes Associated With Apoptotic and Necrotic Pathways in Prostate Cancer DU145 CD133+/CD44+ Cells

[Biochemical and Biophysical Research Communications] Investigators elucidated the effects of senescence induction on proliferation, cell cycle, and apoptosis in prostate cancer stem cells (CSCs) and non-CSCs.

PCK1 Attenuates Tumor Stemness via Activating the Hippo Signaling Pathway in Hepatocellular Carcinoma

[Genes & Diseases] Researchers showed that phosphoenolpyruvate carboxylase 1 (PCK1) inhibited the self-renewal property of hepatoma cells, reduced the mRNA level of cancer stem cell markers, and inhibited tumorigenesis.

Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells

[Advanced Healthcare Materials] Investigators cultured circulating tumor cells (CTC)-like DU4475 triple negative breast cancer cells in mechanically tunable 3D fibrin hydrogel scaffolds. They showed that fibrin hydrogels supported DU4475 cell growth, resulting in spheroid formation.

A Novel TOX3-WDR5-ABCG2 Signaling Axis Regulates the Progression of Colorectal Cancer by Accelerating Stem-Like Traits and Chemoresistance

[PLOS Biology] ABCG2 was found to be markedly up–regulated in colorectal cancer (CRC) CSCs expansion and chemo–resistant CRC tissues and closely associated with CRC recurrence.

Extracellular Vesicle-Carried GTF2I from Mesenchymal Stem Cells Promotes the Expression of Tumor-Suppressive FAT1 and Inhibits Stemness Maintenance in Thyroid Carcinoma

[Frontiers Of Medicine] The effects of bone marrow mesenchymal stem cell-derived extracellular vesicles enriched with GTF2I were evaluated on the epithelial–to–mesenchymal transition and stemness maintenance in thyroid carcinoma.

Ubiquitin-Specific Peptidase 5 Facilitates Cancer Stem Cell-Like Properties in Lung Cancer by Deubiquitinating β-Catenin

[Cancer Cell International] Phenotypic effects of ubiquitin-specific peptidase 5 on the CSC-like properties and metastasis were examined by in vitro sphere formation assay, migration assay, invasion assay, and in vivo xenografted animal models.

Clinical Significance of Porphyromonas gingivalis Enriching Cancer Stem Cells by Inhibiting Programmed Cell Death Factor 4 in Esophageal Squamous Cell Carcinoma

[ACS Infectious Diseases] Scientists investigated the functional mechanism by which Porphyromonas gingivalis (Pg) promoted esophageal squamous cell carcinoma (ESCC) chemoresistance and malignancy through inhibiting PDCD4 and enriching CSCs. The effects of Pg and programmed cell death factor 4 on CSCs, chemoresistance, and malignancy of ESCC cells were evaluated by in vitro studies.

Pan Cancer Characterization of Genes Whose Expression Has Been Associated with LINE-1 Antisense Promoter Activity

[Mobile DNA] Hub long interspersed nuclear element-1 (LINE01) antisense promoter-associated genes CENPU and MCM2 showed a correlation with immune infiltration, clinical T stage, and cancer stemness in pan-cancer.

Cancer Stem Cells of Esophageal Adenocarcinoma are Suppressed by Inhibitors of TRPV2 and SLC12A2

[Annals Of Surgical Oncology] Researchers examined the expression profiles of ion transport-related molecules in the CSCs of esophageal adenocarcinoma.

MPZL1 Suppresses the Cancer Stem-Like Properties of Lung Cancer Through β-Catenin/TCF4 Signaling

[Functional & Integrative Genomics] Scientists explored the influence of myelin protein zero-like protein 1 (MPZL1) on the stem-like properties of cancer cells and the underlying mechanism in lung adenocarcinoma.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.