Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

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P38β-mediated BiP Phosphorylation Drives Stemness and Chemoresistance by Suppressing UPR Activation in Hepatocellular Carcinoma

August 5, 2026

[Nature Communications] Scientists identified the stress kinase p38β (MAPK11) supports tumor-initiating cell maintenance and drug resistance in hepatocellular carcinoma (HCC). Integrated analysis of chemotherapy-enriched HCC spheroids, and DepMap data prioritized p38β as a kinase linked to stemness and chemoresistance.

Mercer School of Medicine Awarded $100,000 Cancer Research Grant

August 5, 2026

[The Den] Mercer University School of Medicine has been awarded the fifth annual Collaborative Cancer Research Seed Grant of $100,000 to advance research aimed at improving treatment for one of the most aggressive forms of endometrial cancer. This grant will support a research project led by Dr. Ilana Chefetz Menaker.

$12.7 Million for Cancer, Heart, and Health Research

August 5, 2026

[Queen's Gazette] 13 research teams at Queen’s University have received a combined $12.7 million from the Canadian Institutes of Health Research (CIHR). Awarded through CIHR's Project Grant: Spring 2026 competition, each project will work towards advancing the wellbeing of Canadians through translational research.

Nanotechnology-Enabled Precision Targeting of Lung Cancer Stem Cells: Recent Developments and Therapeutic Implications

August 5, 2026

[Stem Cell Reviews and Reports] The authors summarize current nanotechnology-enabled strategies targeting lung cancer stem cells, with particular emphasis on tumor microenvironment remodeling, metabolic regulation, and tumor immunity.

Current Therapeutic Interventions to Target Cancer Stem Cells for Metastasis

August 5, 2026

[International Journal of Clinical Oncology] Since CSCs are the major cause of metastatic spread, emerging therapeutic modalities specifically targeting CSCs present a lucrative approach to curtail metastatic disease.

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31-Mediated Degradation of CBX8

August 5, 2026

[Advanced Science] Researchers identifeid WD repeat domain 72 (WDR72) as a cancer stem cell marker that significantly correlates with high-risk of neuroblastoma and poor prognosis in neuroblastoma patients.

Cancer Stem Cells Are Hyper-Responsive Sensors of the Tumor Microenvironment and Regulate Metastasis Dynamics through YAP/TAZ

August 5, 2026

[Nature Cell Biology] Investigators used a fluorescent reporter that marks CSCs to show that CSCs and their more differentiated progeny display strikingly different population dynamics during metastatic lung colonization in breast cancer models.

Dopamine Abrogates Immunosuppression Mediated by PD-L1 of Cancer Stem Cells in a Preclinical Triple-Negative Breast Cancer Model

August 5, 2026

[Acta Pharmacologica Sinica] Using triple negative breast cancer cell lines (TNBC) and CSCs enriched from these cell lines scientists revealed that the PD-1/PD-L1 pathway predominantly mediates CSC-driven immune evasion, growth, and metastasis in TNBC.

The Epigenetic KMT5C-HDAC1 Axis Promotes Hepatocellular Carcinoma Stemness and Progression through SERPINA4 Repression and Chromatin Compaction

August 5, 2026

[Oncogene] Researchers identified the histone methyltransferase KMT5C as master regulator of hepatocellular carcinoma stemness and progression through integrative analyses of patient-derived organoids, murine models, and clinical cohorts.

Paracrine Iron Activates Hopx+ Rectal Cancer Stem Cells to Display Radioresistance

August 5, 2026

[Journal of Advanced Research] Lineage tracing experiments revealed that Hopx+ quiescent stem cell subpopulation exhibited an enhanced regeneration, which functionally drove the recurrence of rectal cancer after irradiation.

Cancer Stem Cell Plasticity: Mechanisms, Immune Microenvironment Crosstalk, and Therapeutic Implications

July 22, 2026

[Journal of Hematology & Oncology] The authors summarize recent advances in our understanding of CSC plasticity, with a particular focus on the bidirectional interplay between CSCs and the tumor immune microenvironment.

LEF1 and Niche Factors Determine T Cell Stemness across Chronic Diseases

July 22, 2026

[Cell] Using preclinical models of autoimmune type 1 diabetes and chronic infection, researchers discovered that a small subset of TCF1hi T cells express the transcription factor LEF1. LEF1+ TCF1hi T cells define a true self-renewing T cell pool.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.