Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

UC San Diego Awarded $8M to Expand Stem Cell Therapy Clinical Trials

[UC San Diego Health] As part of a state-wide effort to advance stem cell therapies, the California Institute for Regenerative Medicine (CIRM) awarded $8 million to the UC San Diego Alpha Stem Cell Clinic. The funding will support the clinic’s mission of bringing new stem cell-based therapies to patients with difficult-to-treat diseases.

Placental Pathology Associated with Lenticulostriate Vasculopathy (LSV) in Preterm Infants

[Journal of Perinatology] Researchers examined the frequency and type of placental abnormalities in neonates with LSV. They found that there were no significant differences for any type of placental abnormities between LSV and control groups.

Editing a Gateway for Cell Therapy across the Blood–Brain Barrier

[Brain] Scientists describe experimental approaches that have been developed in which cells are either engineered to express cell surface proteins mimicking infiltrating immune cells or cell grafts are preconditioned with hypoxia or incubated with pharmacological agents or cytokines.

Elevated CD47 Is a Hallmark of Dysfunctional Aged Muscle Stem Cells That Can Be Targeted to Augment Regeneration

[Cell Stem Cell] Researchers capitalized on mass cytometry to identify high CD47 expression as a hallmark of dysfunctional muscle stem cells with impaired regenerative capacity that predominate with aging.

The IAP Antagonist Birinapant Enhances Chimeric Antigen Receptor T Cell Therapy for Glioblastoma by Overcoming Antigen Heterogeneity

[Molecular Therapy Oncolytics] Investigators developed an approach that combines CAR-T cells with inhibitor of apoptosis protein (IAP) antagonists, a new class of small molecules that mediate the degradation of IAPs, to treat glioblastoma multiforme.

Transplantable Human Thyroid Organoids Generated from Embryonic Stem Cells to Rescue Hypothyroidism

[Nature Communications] The authors reported the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice.

Intravenous Mesenchymal Stem Cell Administration Modulates Monocytes/Macrophages and Ameliorates Asthmatic Airway Inflammation in a Murine Asthma Model

[Molecular and Cellular Biology] Scientists determined the effect of human umbilical cord-derived mesenchymal stem cells on asthmatic lungs by modulating innate immune cells and effector T cells using a murine asthmatic model.

Therapeutic Effects of Anti-PD1 Immunotherapy on Hepatocellular Carcinoma under Administration of Tacrolimus

[Transplantation] Investigators used a murine allogeneic skin transplantation model and murine syngeneic subcutaneous and orthotopic hepatocellular carcinoma models and measured the tumor volume and the change in tumor-infiltrating lymphocytes.

Th2 Cells Inhibit Growth of Colon and Pancreas Cancers by Promoting Anti-Tumorigenic Responses from Macrophages and Eosinophils

[British Journal of Cancer] Scientists identified that T helper (Th) 2 cells were responsible for generation of apoptotic factors and affect macrophage as well as eosinophil recruitment into tumors where they produced cytotoxic factors.

Combined Targeting of Soluble Latent TGF-ß and a Solid Tumor-Associated Antigen with Adapter CAR T Cells

[OncoImmunology] Researchers showed that adapter CAR T cells in combination with the respective adapter can be used to sense soluble tumor-derived latent TGF-β, both in vitro and in vivo.

Engineered T Cell Therapy for Viral and Non-Viral Epithelial Cancers

[Cancer Cell] The authors review and consolidate understanding gained from clinical trials to treat viral and non-viral epithelial cancers with cell and gene therapy and examine how past experience may guide future strategy in treatment and biomarker discovery.

Cell-Based Therapies for Neurological Disorders — the Bioreactor Hypothesis

[Nature Reviews Neurology] Investigators synthesize results from over 20 years of animal studies that illustrate how transdifferentiation, cell replacement, and restoration of damaged tissues in the central nervous system are highly unlikely mechanisms.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.