MaxiVAX and Minaris Regenerative Medicine Enter into a Manufacturing Partnership for MVX-ONCO-2 Cancer Immunotherapy

MaxiVAX SA and Minaris Regenerative Medicine GmbH have entered into a manufacturing agreement for MVX-ONCO-2, a cell-based immunotherapy for the treatment of cancers such as chordoma, head and neck, and other solid tumors.
[MaxiVAX SA]
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CD20 as a Gatekeeper of the Resting State of Human B Cells

Researchers demonstrated that CD20 controlled the nanoscale organization of receptors on the surface of resting B lymphocytes.
[Proceedings of the National Academy of Sciences of the United States of America]
Kläsener, K., Jellusova, J., Andrieux, G., Salzer, U., Böhler, C., Steiner, S. N., Albinus, J. B., Cavallari, M., Süß, B., Voll, R. E., Boerries, M., Wollscheid, B., & Reth, M. (2021). CD20 as a gatekeeper of the resting state of human B cells. Proceedings of the National Academy of Sciences, 118(7). https://doi.org/10.1073/pnas.2021342118 Cite
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Targeting Tumor-Associated Macrophages to Synergize Tumor Immunotherapy

Scientists summarize recent studies investigating the involvement of TAMs in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies.
[Signal Transduction and Targeted Therapy]
Xiang, X., Wang, J., Lu, D., & Xu, X. (2021). Targeting tumor-associated macrophages to synergize tumor immunotherapy. Signal Transduction and Targeted Therapy, 6(1), 1–12. https://doi.org/10.1038/s41392-021-00484-9 Cite
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Identification of Gene Targets of Mutant C/EBPα Reveals a Critical Role for MSI2 in CEBPA-Mutated AML

Integrative analysis identified 117 p30-dependent REs associated with 33 strongly down-regulated genes upon p30-knockdown. CRISPR/Cas9-mediated mutational disruption of these genes revealed the RNA-binding protein MSI2 as a critical p30-target.
[Leukemia]
Heyes, E., Schmidt, L., Manhart, G., Eder, T., Proietti, L., & Grebien, F. (2021). Identification of gene targets of mutant C/EBPα reveals a critical role for MSI2 in CEBPA -mutated AML. Leukemia, 1–13. https://doi.org/10.1038/s41375-021-01169-6 Cite
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Generation of Reconstituted Hemato-Lymphoid Murine Embryos by Placental Transplantation into Embryos Lacking HSCs

Scientists established a procedure for placental HSC transplantation into E11.5 Runx1-deficient mice mated with G1-HRD-Runx1 transgenic mice that had no HSCs in the fetal liver.
[Scientific Reports]
Jeon, H., Asano, K., Wakimoto, A., Kulathunga, K., Tran, M. T. N., Nakamura, M., Yokomizo, T., Hamada, M., & Takahashi, S. (2021). Generation of reconstituted hemato-lymphoid murine embryos by placental transplantation into embryos lacking HSCs. Scientific Reports, 11(1), 4374. https://doi.org/10.1038/s41598-021-83652-9 Cite
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Acquired Cancer Cell Resistance to T Cell Bispecific Antibodies and CAR T Targeting HER2 through JAK2 Down-Modulation

Using T cell bispecific antibodies and chimeric antigen receptors directed against HER2, scientists showed that disruption of interferon-gamma signaling confers resistance to killing by active T lymphocytes.
[Nature Communications]
Arenas, E. J., Martínez-Sabadell, A., Rius Ruiz, I., Román Alonso, M., Escorihuela, M., Luque, A., Fajardo, C. A., Gros, A., Klein, C., & Arribas, J. (2021). Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nature Communications, 12(1), 1237. https://doi.org/10.1038/s41467-021-21445-4 Cite
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Novel AAV Capsids for Intravitreal Gene Therapy of Photoreceptor Disorders

Scientists report the development of novel engineered recombinant adeno‐associated virus vectors that enabled efficient targeting of photoreceptors via less invasive intravitreal administration.
[EMBO Molecular Medicine]
Pavlou, M., Schön, C., Occelli, L. M., Rossi, A., Meumann, N., Boyd, R. F., Bartoe, J. T., Siedlecki, J., Gerhardt, M. J., Babutzka, S., Bogedein, J., Wagner, J. E., Priglinger, S. G., Biel, M., Petersen-Jones, S. M., Büning, H., & Michalakis, S. (2021). Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders. EMBO Molecular Medicine, n/a(n/a), e13392. https://doi.org/10.15252/emmm.202013392 Cite
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Therapeutic Solutions International Uses StemVacs™ Platform to Generate Personalized Adoptive T Cell Therapy Targeting Cancer Stem Cells

Therapeutic Solutions International, Inc., reported novel data and filing of a patent application demonstrating that StemVacs™ cells carrying proprietary sequences from the cancer-specific antigen Brother of the Regulator of Imprinted Sites, were able to elicit the generation of T cells capable of selectively killing cancer stem cells.
[Therapeutic Solutions International, Inc. (PR Newswire)]
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Recent FDA Designation Puts Promising Engineered Cellular Therapy that Reduces Complications of Lymphoma Treatment on Accelerated Path to Market Approval

In November 2020, the FDA granted Regenerative Medicine Advanced Therapy designation for a cellular therapy called AB-205. AB-205 acts promptly to repair injured vascular niches of organs to prevent or reduce severe toxicities in patients who have Hodgkin lymphoma or non-Hodgkin lymphoma undergoing high dose chemotherapy and autologous stem cell transplantation.
[Hackensack University Medical Center (Newswise, Inc.)]
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Reducing Alcohol and/or Cocaine-Induced Reward and Toxicity via an Epidermal Stem Cell-Based Gene Delivery Platform

The authors showed that expression of the glucagon-like peptide-1 gene delivered by epidermal stem cells attenuated development and reinstatement of alcohol-induced drug-taking and seeking as well as voluntary oral alcohol consumption.
[Molecular Psychiatry]
Kong, Q., Li, Y., Yue, J., Wu, X., & Xu, M. (2021). Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform. Molecular Psychiatry, 1–11. https://doi.org/10.1038/s41380-021-01043-y Cite
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Homozygous BCMA Gene Deletion in Response to Anti-BCMA CAR T Cells in a Patient with Multiple Myeloma

Researchers report a case of irreversible B cell maturation antigen (BCMA) loss in a patient with multiple myeloma who was enrolled in the KarMMa trial and progressed after anti-BCMA CAR T cell therapy.
[Nature Medicine]
Da Vià, M. C., Dietrich, O., Truger, M., Arampatzi, P., Duell, J., Heidemeier, A., Zhou, X., Danhof, S., Kraus, S., Chatterjee, M., Meggendorfer, M., Twardziok, S., Goebeler, M.-E., Topp, M. S., Hudecek, M., Prommersberger, S., Hege, K., Kaiser, S., Fuhr, V., … Rasche, L. (2021). Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma. Nature Medicine, 1–4. https://doi.org/10.1038/s41591-021-01245-5 Cite
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