Low serum magnesium levels were associated with more rapid disease progression and shorter overall survival in CAR T cell and immune checkpoint antibody-treated patients.
[Cell]
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Category Archives: Cell Therapy
Cell Therapy NewsCell Therapy News is an online publication and email newsletter dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Published weekly since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
Magnesium Sensing via LFA-1 Regulates CD8+ T Cell Effector Function
Long-Term Safety and Efficacy of Lentiviral Hematopoietic Stem/Progenitor Cell Gene Therapy for Wiskott–Aldrich Syndrome
Scientists presented comprehensive, long-term follow-up results for eight patients with Wiskott–Aldrich syndrome having undergone a Phase I/II lentiviral vector-based gene therapy trial, with a focus on thrombocytopenia and autoimmunity.
[Nature Medicine]
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Transplantation of 3D Adipose-Derived Stem Cell/Hepatocyte Spheroids Alleviates Chronic Hepatic Damage in a Rat Model of Thioacetamide-Induced Liver Cirrhosis
Investigators reported a new approach that enables the formation of self-assembled 3D spheroids of adipose-derived stem cells and murine hepatocytes via reconstituted collagen fibers.
[Scientific Reports]
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EdiGene Enters Strategic R&D Collaboration with Haihe Laboratory of Cell Ecosystem to Develop Hematopoietic Stem Cell Regenerative Therapies and Platform Technologies
EdiGene, Inc. announced a research and development collaboration with Haihe Laboratory of Cell Ecosystem to develop hematopoietic stem cell regenerative therapies and platform technology by combining resources and expertise from both sides.
[EdiGene, Inc. (BusinessWire, Inc.)]
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NK Cells in the Brain: Implications for Brain Tumor Development and Therapy
Natural killer (NK) cells lend themselves to off-the-shelf applications owing to their favorable safety profile and retained efficacy in an allogeneic setting.
[Trends in Molecular Medicine]
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Immune Translational Control by CPEB4 Regulates Intestinal Inflammation Resolution and Colorectal Cancer Development
Researchers addressed the contribution of posttranscriptional regulation, by the RNA-binding protein CPEB4, to intestinal immune homeostasis and its role in inflammatory bowel diseases and CRC development.
[iScience]
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Disrupting N-Glycan Expression on Tumor Cells Boosts Chimeric Antigen Receptor T Cell Efficacy against Solid Malignancies
The authors showed that multiple carcinomas expressed extracellular N-glycans, whose abundance negatively correlated with CAR T cell killing.
[Science Translational Medicine]
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The Current Landscape of Immunotherapy for Pediatric Brain Tumors
Investigators review recent advances and ongoing challenges in pediatric brain cancer immunotherapy, as well as considerations for efficient clinical translation of efficacious immunotherapies into pediatric settings.
[Nature Cancer]
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Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive without Neuroprotection in the Spinal Contusion Cavity
Using a rat cervical hemicontusion model, investigators evaluated the survival and integration of human iPSC-derived spinal motor neurons and oligodendrocyte progenitor cells.
[Frontiers in Cellular Neuroscience]
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SUPT4H1-Edited Stem Cell Therapy Rescues Neuronal Dysfunction in a Mouse Model for Huntington’s Disease
Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.
[NPJ Regenerative Medicine]
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Neurofilament Light Chain Serum Levels Correlate with the Severity of Neurotoxicity after CAR T Cell Treatment
Researchers examined whether serum levels of neurofilament light chain, a marker of neuroaxonal injury, correlated with the severity of immune effector cell-associated neurotoxicity syndrome.
[Blood Advances]
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