Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Kite’s CAR T-Cell Therapy Yescarta®. Granted European Marketing Authorization for the Treatment of Relapsed or Refractory Follicular Lymphoma

[Kite] Kite announced that the European Commission has approved its CAR T-cell therapy Yescarta® for the treatment of adult patients with relapsed or refractory follicular lymphomaafter three or more lines of systemic therapy.

Skyhawk Therapeutics Announces Expansion of its Collaboration Agreement with Merck to Discover and Develop Novel Small Molecules that Modulate RNA Splicing

[Skyhawk Therapeutics, Inc.] Skyhawk Therapeutics, Inc. announced the signing of an exclusive worldwide collaboration agreement with Sanofi to discover and develop novel small molecules that modulate RNA splicing for challenging oncology and immunology targets.

Vertex Announces FDA Has Lifted the Clinical Hold on VX-880 Phase I/II Clinical Trial for the Treatment of Type 1 Diabetes

[Vertex Pharmaceuticals Incorporated] Vertex Pharmaceuticals Incorporated announced that the US FDA has lifted the clinical hold placed on the Phase I/II clinical trial of VX-880, an investigational stem cell-derived, fully differentiated pancreatic islet cell replacement therapy for people with type 1 diabetes with impaired hypoglycemic awareness and severe hypoglycemia.

MicroRNA-206 Down-Regulated Human Umbilical Cord Mesenchymal Stem Cells Alleviate Cognitive Decline in D-Galactose-Induced Aging Mice

[Cell Death Discovery] After daily subcutaneous injection of D-gal (500 mg/kg/d) for 8 weeks, 17-week-old male C57BL/6 J mice were stem cells transplanted by lateral ventricular localization injection.

Impact on Outcomes of Mixed Chimerism of Bone Marrow CD34+ Sorted Cells after Matched or Haploidentical Allogeneic Stem Cell Transplantation for Myeloid Malignancies

[Bone Marrow Transplantation] An investigation of donor/recipient chimerism in the population of bone CD34+ sorted cells was performed in 261 allogeneic hematopoietic stem cell transplantation recipients with myeloid malignancies.

Oligoclonal T-Cell Expansion in a Patient with Bone Marrow Failure after CD19 CAR-T for Richter Transformed DLBCL

[Blood] Scientists presented a case of bone marrow failure in a 57-year old man with diffuse large B-cell lymphoma (DLBCL)-type Richter transformation receiving tisagenlecleucel in a standard-of-care setting.

Performance of Islets of Langerhans Conformally Coated via an Emulsion Cross-Linking Method in Diabetic Rodents and Nonhuman Primates

[Science Advances] The authors developed and validated an augmented conformal coating (CC) method that achieved hydrogel CCs around islets at physiological pH for improved cytocompatibility, with PEG hydrogels for increased biocompatibility and with fivefold increase in encapsulation throughput for enhanced scalability.

An Optimized Ionizable Cationic Lipid for Brain Tumor-Targeted siRNA Delivery and Glioblastoma Immunotherapy

[Biomaterials] A new cationic lipid nanoparticle that could efficiently deliver siRNA across blood-brain barrier and target mouse brain was prepared for modulating the tumor microenvironment for glioblastoma multiforme immunotherapy.

Corneal Fibrosis Abrogation by a Localized AAV Mediated Inhibitor of Differentiation 3 (Id3) Gene Therapy in Rabbit Eyes In Vivo

[Molecular Therapy] Researchers evaluated the potential of adeno-associated virus 5 (AAV5)-mediated Id3 gene therapy to treat corneal scarring using an established rabbit in vivo disease model.

EGF/bFGF Promotes Survival, Migration and Differentiation into Neurons of GFP-Labeled Rhesus Monkey Neural Stem Cells Xenografted into the Rat Brain

[Biochemical and Biophysical Research Communications] Neural stem cells derived from rhesus monkey embryonic stem cells were resuspended in medium with or without epidermal growth factor (EGF)/basic fibroblast growth factor (bFGF) and xenotransplanted into the rat striatum.

A Pilot Clinical Trial of Cell Therapy in Heart Failure with Preserved Ejection Fraction

[European Journal of Heart Failure] Scientists investigated the effects of CD34+ cell therapy in patients with heart failure with preserved ejection fraction.

Evaluation of Chimeric Antigen Receptor of Humanized Rabbit-Derived T Cell Receptor-Like Antibody

[Cancer Science] Investigators reported the generation of CAR-T cells using humanized rabbit-derived TCR-like antibodies.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.