Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Pancreatic Islets Implanted in an Irreversible Electroporation Generated Extracellular Matrix in the Liver

[Radiology and Oncology] Researchers showed that pancreatic islets could become incorporated and function in a non-thermal irreversible electroporation-generated ECM niche, albeit at a low success rate.

Precision Targeting of Autoantigen-Specific B Cells in Muscle-Specific Tyrosine Kinase Myasthenia Gravis with Chimeric Autoantibody Receptor T Cells

[Nature Biotechnology] Researchers engineered T cells to express a muscle-specific tyrosine kinase (MuSK) chimeric autoantibody receptor with CD137-CD3ζ signaling domains for precision targeting of B cells expressing anti-MuSK autoantibodies.

Challenges in the Clinical Advancement of Cell Therapies for Parkinson’s Disease

[Nature Biomedical Engineering] Scientists discuss how challenges pertaining to cell sources, functional and safety testing, manufacturing, and address clinical-trial design to advance the development of cell therapies for Parkinson’s disease.

Transplantation of Hybrid Adipose-Derived Stem Cell Sheet with Autologous Peritoneum: An In Vivo Feasibility Study

[Heliyon] Scientists explored the feasibility of using the peritoneum as a support for the precise transplantation of adipose-derived stem cell sheets during surgery.

Transplanted Human iPSC-Derived Vascular Endothelial Cells Promote Functional Recovery by Recruitment of Regulatory T Cells to Ischemic White Matter in the Brain

[Journal of Neuroinflammation] The authors investigated contribution of the immune system, especially Tregs, to the mechanism whereby human induced pluripotent stem cell transplantation ameliorated white matter infarct.

Application of Nanomaterials in Stem Cell-Based Therapeutics for Cardiac Repair and Regeneration

[Small] Investigators discuss the current status and limitations of stem cells and cell-derived exosomes/micro RNAs based cardiac therapy, and evaluate the advantages and disadvantages of the relevant nanomaterials.

Large-Gap Peripheral Nerve Repair Using Xenogeneic Transplants in Rhesus Macaques

[Xenotransplantation] Researchers reported the repair of fully transected radial nerves in 10 Rhesus Macaques using viable, whole sciatic nerve from genetically engineered, designated pathogen free porcine donors.

Allogeneic BCMA-Targeting CAR T Cells in Relapsed/Refractory Multiple Myeloma: Phase I UNIVERSAL Trial Interim Results

[Nature Medicine] Investigators evaluated escalating doses of ALLO-715 after lymphodepletion with an anti-CD52 antibody (ALLO-647)-containing regimen in 43 patients with relapsed/refractory multiple myeloma.

Improvements in Gut Microbiota Dysbiosis in Aged Mice Transplanted with Adipose-Derived Stem Cells

[Stem Cells And Development] The authors used C57BL/6J mice of different ages to carry out the and extracted adipose-derived stem cells from young mice as donors. They further analyzed the species composition of intestinal microorganisms.

Astrocytes Transplanted during Early Postnatal Development Integrate, Mature, and Survive Long-Term in Mouse Cortex

[Journal Of Neuroscience] To better understand how astrocytes acquire their unique features, scientists transplanted immature mouse cortical astrocytes into the developing cortex of mice and assessed their integration, maturation, and survival.

Safety and Efficacy of Autologous Stem Cell Transplantation in Dialysis-Dependent Myeloma Patients—the DIADEM Study from the Chronic Malignancies Working Party of the EBMT

[Bone Marrow Transplantation] Investigators reported on the outcomes of 110 patients, median age 57 years, who had become dialysis-dependent pre-autologous stem cell transplantation (ASCT) and who underwent a first ASCT.

Enzyme-Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells

[JBMR Plus] Successful engraftment of bone marrow mesenchymal stem cell (MSC) to the new bone formation occured in collagenase-integrated-bone marrow transplantation (BMT) mice, while routine BMT mice did not recruit bone marrow MSC.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.