Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Aurion Biotech Receives Approval From Japan’s PMDA For New Drug Application

[Aurion Biotech] Aurion Biotech announced it has received regulatory approval from Japan’s Pharmaceuticals and Medical Devices Agency, for its novel cell therapy, VyznovaTM for the treatment of bullous keratopathy of the cornea.

Clonal Hematopoiesis and Dysregulation of the Immune System

[Oncotargets And Therapy] The authors focus on the burden of relapsed/refractory pediatric B cell acute lymphoblastic leukemia (B-ALL), the limitations of current strategies, the emerging paradigms for the role of CAR-T in r/r B-ALL, the local perspectives on the health economics and future direction of CAR-T therapies in pediatric patients.

The Infusion of Ex Vivo, Interleukin-15 and -21-Activated Donor NK Cells after Haploidentical HCT in High-Risk AML and MDS Patients—a Randomized Trial

[Leukemia] Clinical effect of donor-derived natural killer cell infusion after HLA-haploidentical hematopoietic cell transplantation (HCT) was evaluated in high-risk myeloid malignancy in Phase 2, randomized trial.

Galectin-3 Expression in Donor T Cells Reduces GvHD Severity and Lethality after Allogeneic Hematopoietic Cell Transplantation

[Cell Reports] Scientists showed that activated donor T cells expressed galectin-3 (Gal-3) after allo-HCT. In both major and minor histocompatibility-mismatched models of murine acute graft versus host disease expression of Gal-3 is associated with decreased T cell activation and suppression of the secretion of effector cytokines.

Intracutaneous Transplantation of Islets within a Biodegradable Temporizing Matrix (BTM) as an Alternative Site for Islet Transplantation

[Diabetes] Investigators tested a clinically proven BTM, a polyurethane-based scaffold, to generate a well-vascularized intracutaneous “neo-dermis” within the skin for islet transplantation.

Conditioned Media of Deer Antler Stem Cells Accelerate Regeneration of Alveolar Bone Defects in Rats

[Cell Proliferation] Researchers investigated the effectiveness of deer Antler stem cells conditioned medium for the repair of surgically-created alveolar bone defects using a rat model and sought to define the underlying mechanisms.

Nanoparticle Pre-Treatment for Enhancing the Survival and Activation of Pulmonary Macrophage Transplant

[Drug Delivery And Translational Research] Given recent discoveries of nanoparticle strategies in improving macrophage survival and promoting phenotype retention, Investigators reported the ability to extend the survival and phenotype of macrophage transplants in murine lungs via pre-treatment with nanoparticles of varying degradation rates.

Role of Allogeneic Hematopoietic Cell Transplant for Relapsed/Refractory Aggressive B-cell Lymphomas in the CAR T Era

[Bone Marrow Transplantation] Scientists selected patients with the following characteristics: CART or allogeneic hematopoietic cell transplantation (alloHCT) performed between 2016 and 2021; ≥18 years old; ABCL diagnosis; ≥2 lines of therapy; and either anti-CD19 CART or alloHCT as therapy at relapse. In the multivariate analysis, CART was confirmed to be similar to alloHCT for the primary study endpoint.

Efficacy of Salvage Treatments in Relapsed or Refractory Diffuse Large B-Cell Lymphoma including Chimeric Antigen Receptor T-Cell Therapy: A Systematic Review and Meta-Analysis

[Cancer Research And Treatment] Investigators evaluated the efficacy of salvage treatments for relapsed or refractory diffuse large B-cell lymphoma through meta-analysis.

Rapid and Effective Preparation of Clonal Bone Marrow-Derived Mesenchymal Stem/Stromal Cell Sheets to Reduce Renal Fibrosis

[Scientific Reports] Scientists engineered clonal human bone marrow mesenchymal stem/stromal cell (cBMSC) sheets in 24 h to provide rapid preparation. They then sought to determine the influence of cBMSC freeze-thawing on both in vitro production of pro-regenerative factors and in vivo ability to reduce renal fibrosis in a rat model compared to freshly harvested cBMSCs.

Chimeric Antigen Receptor T Therapy for Adult B-Cell Acute Lymphoblastic Leukemia: State-Of the-(C)ART and Road Ahead

[Blood Advances] Investigators evaluate the evolving role of allogeneic hematopoietic stem cell transplantation in the CAR T era, and discuss lessons learned from the first steps with CAR T in acute lymphoblastic leukemia.

Vaccitech’s VTP-200 Ph Ib/II Study Demonstrates Favorable Tolerability and Immunogenicity Profile at Interim Analysis in Women with Low-Grade Human Papillomavirus (HPV)-Related Cervical Lesions

[Vaccitech plc] Vaccitech plc announced topline interim data from the HPV001 study, a Phase Ib/II clinical trial of VTP-200 in women with low-grade cervical HPV lesions.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.