Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Cell Therapy News
Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Peptide-Oligonucleotide Nanohybrids Designed for Precise Gene Therapy of Rheumatoid Arthritis
[Advanced Materials] A novel kind of engineered peptide and oligonucleotide nanohybrids were designed and fabricated, which provide various advantages including good biosafety, inflammatory region-targeted delivery, cell membrane penetration, reactive oxygen species scavenging, and endolysosomal escape.
Cas12a-Knock-In Mice for Multiplexed Genome Editing, Disease Modeling, and Immune-Cell Engineering
[Nature Biomedical Engineering] Scientists described a series of knock-in mice with a C57BL/6 background and with the conditional or constitutive expression of LbCas12a or of high-fidelity enhanced AsCas12a, which were inserted at the Rosa26 locus.
T Cell Receptor Precision Editing of Regulatory T Cells for Celiac Disease
[Science Translational Medicine] The authors showed that engineered regulatory T cells modified to orthotopically express T cell receptors specific to gluten peptides could quiet gluten-reactive effector T cells in vitro and in vivo.
CD24-Targeted CAR-T Cells Mediated Long-Term Anti-Tumor Efficacy through Activation of Endogenous Tumor Immune Responses
[Molecular Cancer Therapeutics] Scientists reported that CAR-T cells targeting CD24, a potential tumor biomarker and an innate immune checkpoint molecular, evoked robust anti-tumor efficacy and elicited long-term tumor regression.
VDAC2 Loss Elicits Tumor Destruction and Inflammation for Cancer Therapy
[Nature] Using complementary in vivo and in vitro CRISPR–Cas9 genetic screens to target metabolic factors, scientists established voltage-dependent anion channel 2 (VDAC2) as an immune signal-dependent checkpoint that curtailed interferon-γ (IFNγ)-mediated tumor destruction and inflammatory reprogramming of the tumor microenvironment.
Cell Therapy for Liver Disorders: Past, Present, and Future
[Nature Reviews Gastroenterology & Hepatology] Scientists focus on the advantages and drawbacks of distinct cell sources and the relative strategies to address different therapeutic needs in distinct liver diseases.
CAR-NK Cell Therapy Combined with Checkpoint Inhibition Induces an NKT Cell Response in Glioblastoma
[British Journal of Cancer] Advanced GL261/HER2 tumors were treated by local CAR-NK cell injection combined with systemic anti-PD-1 checkpoint blockade.
CRISPR Targeting of SNPs Associated with Age-Related Macular Degeneration in ARPE-19 Cells: A Potential Model for Manipulating the Complement System
[Gene Therapy] The authors conducted targeted PCRs to identify age-related Macular degeneration-related single nucleotide polymorphisms in ARPE-19 cells and used CRISPR constructs to assess allele-specific activity.
Progress in Skin Gene Therapy: From the Inside and Out
[Molecular Therapy] Investigators examine the current approaches of cell and gene therapies for genetic skin disorders.
Locoregional Infusion of EGFR806-CAR T Cells for Recurrent or Refractory Pediatric CNS Tumors: Results of the Completed BrainChild02 Phase 1 Clinical Trial
[Neuro-Oncology] In this open-label Phase I clinical trial, patients age 1-26 years with EGFR+ CNS tumors received weekly infusions of 1-2.5 x 107 CAR T cells into the tumor resection bed or the lateral ventricle via an implanted catheter.
Characterization of Diverse Cas9 Orthologs for Genome and Epigenome Editing
[Proceedings of The National Academy of Sciences of The United States of America] Researchers assessed a diversity of Cas9 orthologs and described four effectors that function in mammalian cells, with the Streptococcus uberis Cas9 as a particularly promising chassis for genome, transcriptome, and epigenome editing.
Dual mRNA Nanoparticles Strategy for Enhanced Pancreatic Cancer Treatment and β-elemene Combination Therapy
[Proceedings of The National Academy of Sciences of The United States of America] The authors demonstrated that mRNA polymeric nanoparticles encoding anti-PD-1 antibodies in situ at the tumor site enhanced the therapeutic efficacy of neoantigen-based mRNA vaccine for pancreatic ductal adenocarcinoma.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
