Magnesium Sensing via LFA-1 Regulates CD8+ T Cell Effector Function

Low serum magnesium levels were associated with more rapid disease progression and shorter overall survival in CAR T cell and immune checkpoint antibody-treated patients.
[Cell]
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Long-Term Safety and Efficacy of Lentiviral Hematopoietic Stem/Progenitor Cell Gene Therapy for Wiskott–Aldrich Syndrome

Scientists presented comprehensive, long-term follow-up results for eight patients with Wiskott–Aldrich syndrome having undergone a Phase I/II lentiviral vector-based gene therapy trial, with a focus on thrombocytopenia and autoimmunity.
[Nature Medicine]
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Transplantation of 3D Adipose-Derived Stem Cell/Hepatocyte Spheroids Alleviates Chronic Hepatic Damage in a Rat Model of Thioacetamide-Induced Liver Cirrhosis

Investigators reported a new approach that enables the formation of self-assembled 3D spheroids of adipose-derived stem cells and murine hepatocytes via reconstituted collagen fibers.
[Scientific Reports]
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EdiGene Enters Strategic R&D Collaboration with Haihe Laboratory of Cell Ecosystem to Develop Hematopoietic Stem Cell Regenerative Therapies and Platform Technologies

EdiGene, Inc. announced a research and development collaboration with Haihe Laboratory of Cell Ecosystem to develop hematopoietic stem cell regenerative therapies and platform technology by combining resources and expertise from both sides.
[EdiGene, Inc. (BusinessWire, Inc.)]
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NK Cells in the Brain: Implications for Brain Tumor Development and Therapy

Natural killer (NK) cells lend themselves to off-the-shelf applications owing to their favorable safety profile and retained efficacy in an allogeneic setting.
[Trends in Molecular Medicine]
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Immune Translational Control by CPEB4 Regulates Intestinal Inflammation Resolution and Colorectal Cancer Development

Researchers addressed the contribution of posttranscriptional regulation, by the RNA-binding protein CPEB4, to intestinal immune homeostasis and its role in inflammatory bowel diseases and CRC development.
[iScience]
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Disrupting N-Glycan Expression on Tumor Cells Boosts Chimeric Antigen Receptor T Cell Efficacy against Solid Malignancies

The authors showed that multiple carcinomas expressed extracellular N-glycans, whose abundance negatively correlated with CAR T cell killing.
[Science Translational Medicine]
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The Current Landscape of Immunotherapy for Pediatric Brain Tumors

Investigators review recent advances and ongoing challenges in pediatric brain cancer immunotherapy, as well as considerations for efficient clinical translation of efficacious immunotherapies into pediatric settings.
[Nature Cancer]
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Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive without Neuroprotection in the Spinal Contusion Cavity

Using a rat cervical hemicontusion model, investigators evaluated the survival and integration of human iPSC-derived spinal motor neurons and oligodendrocyte progenitor cells.
[Frontiers in Cellular Neuroscience]
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SUPT4H1-Edited Stem Cell Therapy Rescues Neuronal Dysfunction in a Mouse Model for Huntington’s Disease

Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.
[NPJ Regenerative Medicine]
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Neurofilament Light Chain Serum Levels Correlate with the Severity of Neurotoxicity after CAR T Cell Treatment

Researchers examined whether serum levels of neurofilament light chain, a marker of neuroaxonal injury, correlated with the severity of immune effector cell-associated neurotoxicity syndrome.
[Blood Advances]
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