Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Council Calls for Transparent, Equitable, and Open Access to Scholarly Publications

[Council of the European Union] The Council has adopted conclusions on the ‘high quality, transparent, open, trustworthy and equitable scholarly publishing’, in which it calls for immediate and unrestricted open access in publishing research involving public funds.

Thousands of Early-Career NIH Researchers Forming Union for First Time

[Nature News] Thousands of early-career researchers at the US National Institutes of Health (NIH) have kick-started the process of forming a union. They are calling on the agency — the world’s largest biomedical funder — to raise pay and improve benefits, as well as to bolster its policies and procedures on harassment and excessive workloads.

UO’s Knight Campus Reveals Design of Second Science Building and New Engineering Program

[Oregon Public Broadcasting] The University of Oregon’s Knight Campus has released design details of its second science building now under construction. The sprawling facility will enable the evolution of a new bioengineering program at the unviersity.

Tumor-Intrinsic Sensitivity to the Pro-Apoptotic Effects of IFN-γ Is a Major Determinant of CD4+ CAR T-Cell Antitumor Activity

[Nature Cancer] With the help of functional intravital imaging, scientists reported that interferon (IFN)-γ production but not perforin-mediated cytotoxicity was the dominant mechanism for tumor elimination by anti-CD19 CD4+ CAR T cells.

Hematopoietic Reconstitution Dynamics of Mobilized- and Bone Marrow-Derived Human Hematopoietic Stem Cells After Gene Therapy

[Nature Communications] Investigators presented an unplanned exploratory analysis evaluating the hematopoietic reconstitution kinetics, engraftment, and clonality in 13 pediatric Wiskott-Aldrich syndrome patients treated with autologous lentiviral-vector transduced hematopoietic stem/progenitor cells derived from mobilized peripheral blood, bone marrow or the combination of the two sources

Rescue of Auditory Function by a Single Administration of AAV-TMPRSS3 Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8

[Molecular Therapy] A single adeno-associated virus-humanTMPRSS3 injection in Tmprss3A306T/A306T mice of an average age of 18.5 months led to the sustained rescue of the auditory function to a level similar to wild-type mice.

Suicide Gene Therapy Using Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cell Gene Delivery Vehicles in Recurrent Glioblastoma Multiforme: A First-in-Human, Dose-Escalation, Phase I Clinical Trial

[Journal Of Translational Medicine] Researchers showed that suicide gene therapy using allogeneic adipose tissue-derived mesenchymal stem cells carrying the herpes simplex virus-thymidine kinase gene was safe in patients with recurrent glioblastoma multiforme.

Transplantation of Human Brain-Derived Ischemia-Induced Multipotent Stem Cells Ameliorates Neurological Dysfunction in Mice After Stroke

[Stem Cells Translational Medicine] Investigators performed a preclinical study by transplanting human brain-derived-induced multipotent stem cells transcranially into post-stroke mouse brains 6 weeks after middle cerebral artery occlusion.

Lenalidomide Overcomes the Resistance to Third-Generation CD19-CAR-T Cell Therapy in Preclinical Models of Diffuse Large B-Cell Lymphoma

[Cellular Oncology] Germinal center B-cell-like diffuse large B-cell lymphoma cell line OCI-Ly1, and patient-derived xenografted mice were used as the CAR-T cell-resistant model.

A Novel Bispecific T-Cell Engager (BiTE) Targeting CD22 and CD3 Has Both In Vitro and In Vivo Activity and Synergizes With Blinatumomab in an...

[Cancer Immunology Immunotherapy] Scientists reported the development of a new BiTE with cytotoxic activity against CD22+ cells which could represent an alternate or complementary therapeutic option for B cell malignancies.

VEGF Overexpressed Mesoangioblasts Enhance Urethral and Vaginal Recovery Following Simulated Vaginal Birth in Rats

[Scientific Reports] Female rats were assigned to either injection of saline, allogeneic-mesoangioblasts (MABs), autologous-MABs or allogeneic-MABs transduced to stably expressed vascular endothelial growth factor (VEGF).

Infectious Complications Following CAR-T Cell Therapy for B Cell Non-Hodgkin Lymphoma: A Single-Center Experience and Review of the Literature

[Annals Of Hematology] Investigators report a single-center retrospective study of infectious complications following CAR-T cell therapy in 48 adult patients with relapsed and refractory B cell non-Hodgkin lymphoma.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.