Suprachoroidal injection of nanoparticles containing a VEGF-binding protein expression plasmid significantly suppressed VEGF-induced vascular leakage and neovascularization demonstrating therapeutic potential.
Researchers discuss the current research advances in strategies to obtain insulin-producing cells from different precursor cells and in stem cell-based therapies for diabetes.
[Stem Cell Research & Therapy]
International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
In this Phase I dose escalation study, the authors assessed the safety of a donor lymphocyte infusion that was depleted of CD45RA+ naive T cells.
[Bone Marrow Transplantation]
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Maung, K. K., Chen, B. J., Barak, I., Li, Z., Rizzieri, D. A., Gasparetto, C., … Horwitz, M. E. (2020). Phase I dose escalation study of naive T-cell depleted donor lymphocyte infusion following allogeneic stem cell transplantation. Bone Marrow Transplantation, 1–7. https://doi.org/10.1038/s41409-020-0991-5 Cite
Flow cytometry demonstrated that irradiation led to a significant reduction in the peripheral blood endothelial progenitor cell (EPC) count; however, EPC transplantation led to a significant increase in the circulating EPCs.
This study was conducted to determine the long-term outcomes of cultivated cell sheet transplantation, and to clarify risk factors that affected the outcomes.
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Researchers developed a combined nano-cell therapy by using dendrimers complexed with plasmids targeting CCL20 and its sole receptor CCR6 to reduce inflammation followed by human mesenchymal stem cell transplantation.
[Nanomedicine-Nanotechnology Biology and Medicine]
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Mayilsamy, K., Markoutsa, E., Das, M., Chopade, P., Puro, D., Kumar, A., … Mohapatra, S. (2020). Treatment with shCCL20-CCR6 nanodendriplexes and human mesenchymal stem cell therapy improves pathology in mice with repeated traumatic brain injury. Nanomedicine: Nanotechnology, Biology and Medicine, 102247. https://doi.org/10.1016/j.nano.2020.102247 Cite
Using a rat contusive spinal cord injury model, scientists evaluated the survival, migration and differentiation of urine derived induced pluripotent stem cell-neural progenitor cells after transplantation at subacute phase.
Scientists aimed to determine whether human bone marrow mesenchymal stem cells can differentiate into biliary epithelial cells in vitro and in vivo and to clarify the role of delta-like ligand 4 (DLL4) in restoring damaged liver by enhancing cholangiocyte differentiation.
[Stem Cell Research]
Investigators demonstrated 89Zr-oxine labeling and PET-CT imaging as a potential clinical solution for non-invasively tracking MSCTRAIL biodistribution
[Stem Cell Research & Therapy]
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AVROBIO, Inc. announced that the first patient has been dosed in the company’s GuardOne clinical trial, a Phase I/II investigational study evaluating AVR-RD-02 for Gaucher disease type 1.
Celixir announced an update to its ongoing clinical programme with lead therapeutic candidate CLXR-001.
[Celixir (GlobeNewswire, Inc.)]