Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Third Party CMV Viral Specific T-Cells for Refractory CMV Viremia and Disease after Hematopoietic Transplant

[Journal Of Clinical Investigation] In Phase I/II trials, scientists treated 67 subjects for CMV viremia or disease arising after allogeneic hematopoietic cell transplant with adoptive transfer of banked off-the-shelf, 3rd party, CMVpp65-sensitized T cells.

Modular-Designed Engineered Bacteria for Precision Tumor Immunotherapy via Spatiotemporal Manipulation by Magnetic Field

[Nature Communications] Investigators described an alternating magnetic field-manipulated tumor-homing bacteria developed by genetically modifying engineered Escherichia coli with Fe3O4@lipid nanocomposites.

Rhodiola rosea Polysaccharides-Based Nanoparticles Loaded with DOX Boosts Chemo-Immunotherapy for Triple-Negative Breast Cancer by Re-educating Tumor-Associated Macrophages

[International Journal Of Biological Macromolecules] Scientists described a Rhodiola rosea polysaccharides-based hydrophobic delivery vector and achieved an additional helpful antitumor effect by modulating tumor-associated macrophages.

Potential of an Aligned Porous Hydrogel Scaffold Combined with Periodontal Ligament Stem Cells or Gingival Mesenchymal Stem Cells to Promote Tissue Regeneration in Rat...

[ACS Biomaterials Science & Engineering] A constructed aligned porous hydrogel scaffold carrying cells based on chitosan and oxidized chondroitin sulfate treated with a freeze-casting technique was fabricated, which aimed to induce the arrangement of periodontal tissue regeneration.

Differentiation of Patient-Specific Void Urine-Derived Human Induced Pluripotent Stem Cells to Fibroblasts and Skeletal Muscle Myocytes

[Scientific Reports] Researchers established a workflow using iPSC-derived fibroblasts and skeletal myocytes for urethral tissue regeneration, allowing scalable derivation, culture, and in vivo tracing of patient-specific fibroblasts and myocytes, which can be assessed in rat stress urinary incontinence models to regenerate urethral damages and restore continence.

GD2 CAR-T Cells in Combination with Nivolumab Exhibit Enhanced Antitumor Efficacy

[Translational Oncology] A combined therapeutic strategy was tested in the current study using GD2 CAR T together with Nivolumab, an anti-PD-1 monoclonal antibody. Animal studies suggested that GD2 CAR T effectively infiltrated into tumor tissue and significantly hampered tumor progression.

Novel Nanotherapeutics for Cancer Immunotherapy by CTLA-4 Aptamer-Functionalized Albumin Nanoparticle Loaded with Antihistamine

[Journal Of Cancer Research And Clinical Oncology] To improve immune checkpoint blockade, fexofenadine, an antihistamine, was encapsulated into aptamer-modified nanostructure to make a drug-loaded nanoparticle.

iPSC-Derived Tenocytes Seeded on Microgrooved 3D Printed Scaffolds for Achilles Tendon Regeneration

[Journal Of Orthopaedic Research] Scientists assessed the application of novel 3D printed scaffolds and induced pluripotent stem cell-derived mesenchymal stem cells overexpressing the transcription factor Scleraxis as a new strategy for tendon defect repair.

A Tunable Calcium Phosphate Coating to Drive In Vivo Osseointegration of Composite Engineered Tissues

[Cells Tissues Organs] Investigators successfully fabricated polycaprolactone salt-leached scaffolds with two levels of a biomimetic calcium phosphate coating to examine their effects on mesenchymal stem cell osteogenesis. They also demonstrated that the use of simulated body fluid-based hydroxyapatite coatings promoted higher levels of osteogenesis in vivo.

Cell and Gene Therapy for Kidney Disease

[Nature Reviews Nephrology] The authors describe the potential for cell and gene therapy in treating kidney disease, focusing on recent genetic studies, key advances, and emerging technologies, describing several crucial considerations for renal genetic and cell therapies.

Advancing Cell-Based Cancer Immunotherapy through Stem Cell Engineering

[Cell Stem Cell] Investigators review stem cell-based immunotherapy approaches, stem cell sources, gene engineering and manufacturing strategies, therapeutic platforms, and clinical trials, as well as challenges and future directions for the field.

Aurion Biotech Receives Approval From Japan’s PMDA For New Drug Application

[Aurion Biotech] Aurion Biotech announced it has received regulatory approval from Japan’s Pharmaceuticals and Medical Devices Agency, for its novel cell therapy, VyznovaTM for the treatment of bullous keratopathy of the cornea.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.