Allogeneic Stem Cell Transplantation for Patients with Aggressive NK-Cell Leukemia

Using the Japanese transplant registry data, the outcomes of 59 aggressive NK-cell leukemia patients who underwent first allogeneic hematopoietic stem cell transplantation were analyzed. Twenty-nine patients received stem cells from cord blood, 18 from peripheral blood, and 12 from bone marrow.
[Bone Marrow Transplantation]
Fujimoto, A., Ishida, F., Izutsu, K., Yamasaki, S., Chihara, D., Suzumiya, J., Mitsui, T., Doki, N., Sakai, H., Kobayashi, H., Kanda, J., Fukuda, T., Atsuta, Y., & Suzuki, R. (2020). Allogeneic stem cell transplantation for patients with aggressive NK-cell leukemia. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01009-8 Cite
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Progress of Gene Therapy in Cardiovascular Disease

Researchers discuss the recent advances in proangiogenic gene therapy for critical limb ischemia and DNA vaccine for hypertension.
[Hypertension]
Shimamura Munehisa, Nakagami Hironori, Sanada Fumihiro, & Morishita Ryuichi. (n.d.). Progress of Gene Therapy in Cardiovascular Disease. Hypertension, 0(0), HYPERTENSIONAHA.120.14478. https://doi.org/10.1161/HYPERTENSIONAHA.120.14478 Cite
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Transplantation of Human Amnion Epithelial Cells Improves Endometrial Regeneration in Rat Model of Intrauterine Adhesions

Investigators found that PKH26-labeled human amniotic epithelial cells mainly distributed in the basal layer of endometrium after transplantation.
[Stem Cells and Development]
Ouyang, X., You, S., zhang, Y., Zhang, C., Zhang, G., Shao, X., He, F., & Hu, L. (2020). Transplantation of human amnion epithelial cells improves endometrial regeneration in rat model of intrauterine adhesions. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0246 Cite
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Hemogenyx Partners with UPenn to Study CAR T-Cell Therapy in AML

Hemogenyx Pharmaceuticals has inked a research agreement with the University of Pennsylvania (UPenn) for its CAR T-cell therapy for acute myeloid leukemia (AML).
[Hemogenyx Pharmaceuticals (Precision Oncology News)]
Press Release

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Celyad to Begin Phase I Trial of Donor-Derived CAR T-Cell Therapy for Multiple Myeloma

Celyad Oncology SA announced that the company’s Investigational New Drug (IND) application for CYAD-211, the company’s first-in-class short hairpin RNA-based allogeneic CAR T candidate and second non-gene edited off-the-shelf program, is in effect with the FDA.
[Celyad Oncology SA]
Press Release

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Ocugen Receives Fourth FDA Orphan Drug Designation for the Same Product, OCU400 (AAV-NR2E3) Gene Therapy, for the Treatment of Another Key Inherited Retinal Disease (IRD), PDE6B Gene Mutation-Associated Retinal Diseases

Ocugen, Inc. announced the FDA granted the fourth Orphan Drug Designation for OCU400 in the treatment of PDE6B gene mutation-associated retinal diseases.
[Ocugen, Inc.]
Press Release

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Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes

To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
Liu, C., Kang, L.-N., Chen, F., Mu, D., Shen, S., Wang, K., Hu, J.-X., Xie, J., & Xu, B. (2020). Immediate intracoronary delivery of human umbilical cord mesenchymal stem cells reduces myocardial injury by regulating the inflammatory process via cell-cell contact with T lymphocytes. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0264 Cite
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Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome

The authors focus on the therapeutic potential of mesenchymal stem/stromal cells (MSCs). MSCs are available from several tissues, including bone marrow, umbilical cord, and adipose tissue.
[Seminars in Respiratory and Critical Care Medicine]
Byrnes, D., Masterson, C. H., Artigas, A., & Laffey, J. G. (2020). Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome. Seminars in Respiratory and Critical Care Medicine. https://doi.org/10.1055/s-0040-1713422 Cite
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Sangamo Announces Global Collaboration with Novartis to Develop Genomic Medicines for Autism and other Neurodevelopmental Disorders

Sangamo Therapeutics, Inc. announced that it has executed a global licensing collaboration agreement with Novartis to develop and commercialize gene regulation therapies to address three neurodevelopmental targets, including autism spectrum disorder and other neurodevelopmental disorders.
[Sangamo Therapeutics]
Press Release

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Celularity Announces the Activation of First California Clinical Trial Site following CIRM Grant Award to Advance Treatments for COVID-19

Celularity announced that it has been awarded a $750,000 COVID-19 Project grant by the California Institute for Regenerative Medicine (CIRM), one of the three clinical awards targeting the coronavirus. This grant will support California Institutions participating in the Phase I/II clinical trial of human placental hematopoietic stem cell derived natural killer cells for the treatment of adults with COVID-19.
[Celularity Inc.]
Press Release

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Gene Therapy for Alpha 1-Antitrypsin Deficiency with an Oxidant-Resistant Human Alpha 1-Antitrypsin

Scientists hypothesized that a onetime administration of a serotype 8 adeno-associated virus gene transfer vector coding for the oxidation-resistant variant alpha 1-antitrypsin (AAT) would maintain antiprotease activity under oxidant stress compared with normal AAT.
[JCI Insight]
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