Bayer subsidiary BlueRock Therapeutics has been granted a fast-track review by the FDA for DA01, its stem cell-based therapy for Parkinson’s disease which is currently in early-stage clinical testing.
[PharmaPhorum]
Category Archives: Cell Therapy
Cell Therapy NewsCell Therapy News is an online publication and email newsletter dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Published weekly since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
FDA Gives Speedy Review to Bayer’s Parkinson’s Stem Cell Therapy
Ottawa Researchers Receive $8 Million to Find Answers on COVID Vaccines, Cancer
Ottawa researchers have been awarded more than $8 million to lead four national studies in pursuit of answers about how well COVID-19 vaccines work in people with cancer and other health conditions.
[Ottawa Citizen]
High-Throughput and Single-Cell T Cell Receptor Sequencing Technologies
The authors highlight advances in high-throughput sequencing technologies to identify TCR sequences and describe how they have been applied to discover fundamental insights into T cell-mediated immunity.
[Nature Methods]
Pai, J. A., & Satpathy, A. T. (2021). High-throughput and single-cell T cell receptor sequencing technologies. Nature Methods, 1–12. https://doi.org/10.1038/s41592-021-01201-8 Cite
Depletion of High-Content CD14+ Cells from Apheresis Products Is Critical for the Successful Transduction and Expansion of CAR T Cells during Large-Scale cGMP Manufacturing
Investigators found that high CD14+ cell content posed a challenge for manufacturing CAR T cells especially in patients with non-Hodgkin’s lymphoma and multiple myeloma due to the non-specific phagocytosis of the magnetic beads used to activate CD3+ T cells.
[Molecular Therapy-Methods & Clinical Development]
Wang, X., Borquez-Ojeda, O., Stefanski, J., Du, F., Qu, J., Chaudhari, J., Thummar, K., Zhu, M., Shen, L., Hall, M., Gautam, P., Wang, Y., Senechal, B., Sikder, D., Adusumilli, P. S., Brentjens, R. J., Curran, K., Geyer, M. B., Mailankhody, S., … Rivière, I. (2021). Depletion of High-Content CD14+ Cells from Apheresis Products is Critical for the Successful Transduction and Expansion of CAR T cells during Large-scale cGMP Manufacturing. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.06.014 Cite
Characterization of Neoantigen-Specific T Cells in Cancer Resistant to Immune Checkpoint Therapies
Leveraging the use of mass cytometry combined with multiplex major histocompatibility complex class I tetramer staining, researchers screened and identified tumor neoantigen–specific CD8+ T cells in the Lewis Lung carcinoma tumor model.
[Proceedings of the National Academy of Sciences of the United States of America]
Wang, X., Borquez-Ojeda, O., Stefanski, J., Du, F., Qu, J., Chaudhari, J., Thummar, K., Zhu, M., Shen, L., Hall, M., Gautam, P., Wang, Y., Senechal, B., Sikder, D., Adusumilli, P. S., Brentjens, R. J., Curran, K., Geyer, M. B., Mailankhody, S., … Rivière, I. (2021). Depletion of High-Content CD14+ Cells from Apheresis Products is Critical for the Successful Transduction and Expansion of CAR T cells during Large-scale cGMP Manufacturing. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.06.014 Cite
Gene Therapy for Spinal Muscular Atrophy: The Qatari Experience
Researchers described Qatari experience with onasemnogene abeparvovec by reviewing the clinical outcomes of nine spinal muscular atrophy children.
[Gene Therapy]
Ali, H. G., Ibrahim, K., Elsaid, M. F., Mohamed, R. B., Abeidah, M. I. A., Al Rawwas, A. O., Elshafey, K., Almulla, H., El-Akouri, K., Almulla, M., Othman, A., Musa, S., Al-Mesaifri, F., Ali, R., Shahbeck, N., Al-Mureikhi, M., Alsulaiman, R., Alkaabi, S., & Ben-Omran, T. (2021). Gene therapy for spinal muscular atrophy: the Qatari experience. Gene Therapy, 1–5. https://doi.org/10.1038/s41434-021-00273-7 Cite
Pulmonary Transplantation of Alpha-1 Antitrypsin (AAT)-Transgenic Macrophages Provides a Source of Functional Human AAT In Vivo
The authors investigated the pulmonary transplantation of macrophages transgenic for alpha-1 antitrypsin (AAT) as a potential therapy for AAT deficiency-associated lung pathology.
[Gene Therapy]
Janosz, E., Hetzel, M., Spielmann, H., Tumpara, S., Rossdam, C., Schwabbauer, M., Kloos, D., von Kaisenberg, C., Schambach, A., Buettner, F. F. R., Janciauskiene, S., Lachmann, N., & Moritz, T. (2021). Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo. Gene Therapy, 1–17. https://doi.org/10.1038/s41434-021-00269-3 Cite
Impact of Gut Fungal and Bacterial Communities on the Outcome of Allogeneic Hematopoietic Cell Transplantation
Investigators evaluated the bacterial and fungal composition of the fecal microbiota at day 0 of allogeneic hematopoietic cell transplantation.
[Mucosal Immunology]
Malard, F., Lavelle, A., Battipaglia, G., Gaugler, B., Dulery, R., Brissot, E., Mediavilla, C., Jegou, S., Rolhion, N., Ledraa, T., Mohty, R., Sokol, H., & Mohty, M. (2021). Impact of gut fungal and bacterial communities on the outcome of allogeneic hematopoietic cell transplantation. Mucosal Immunology, 1–6. https://doi.org/10.1038/s41385-021-00429-z Cite
Engineered Mucoperiosteal Scaffold for Cleft Palate Regeneration towards the Non-immunogenic Transplantation
The authors set up a new natural scaffold deriving from a decellularized porcine mucoperiosteum, engineered by an innovative micro-perforation procedure based on Quantum Molecular Resonance and then subjected to in vitro recellularization with human bone marrow-derived mesenchymal stem cells.
[Scientific Reports]
Rizzo, M. I., Tomao, L., Tedesco, S., Cajozzo, M., Esposito, M., De Stefanis, C., Ferranti, A. M., Mezzogori, D., Palmieri, A., Pozzato, G., Algeri, M., Locatelli, F., Leone, L., & Zama, M. (2021). Engineered mucoperiosteal scaffold for cleft palate regeneration towards the non-immunogenic transplantation. Scientific Reports, 11(1), 14570. https://doi.org/10.1038/s41598-021-93951-w Cite
Dexamethasone Enhances the Lung Metastasis of Breast Cancer via a PI3K-SGK1-CTGF Pathway
Ligation of Dex and glucocorticoid receptor on tumor cells activated the PI3K signaling pathway and upregulated serum glucocorticoid-inducible kinase 1 expression, and then increased the expression of connective tissue growth factor through Nedd4l-Smad2.
[Oncogene]
Zhang, Y., Shi, G., Zhang, H., Xiong, Q., Cheng, F., Wang, H., Luo, J., Zhang, Y., Shi, P., Xu, J., Fu, J., Chen, N., Cheng, L., Li, Y., Dai, L., Yang, Y., Yu, D., Zhang, S., & Deng, H. (2021). Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway. Oncogene, 1–12. https://doi.org/10.1038/s41388-021-01944-w Cite
Cell Therapy in Patients with COVID-19 Using Wharton’s Jelly Mesenchymal Stem Cells: A Phase I Clinical Trial
Scientists assessed the safety and efficacy of injecting intravenous Wharton’s jelly-derived MSCs in patients with COVID-19 as a treatment. Five patients with severe COVID-19 were treated with Wharton’s jelly-derived mesenchymal stem cells.
[Stem Cell Research & Therapy]
Saleh, M., Vaezi, A. A., Aliannejad, R., Sohrabpour, A. A., Kiaei, S. Z. F., Shadnoush, M., Siavashi, V., Aghaghazvini, L., Khoundabi, B., Abdoli, S., Chahardouli, B., Seyhoun, I., Alijani, N., & Verdi, J. (2021). Cell therapy in patients with COVID-19 using Wharton’s jelly mesenchymal stem cells: a phase 1 clinical trial. Stem Cell Research & Therapy, 12(1), 410. https://doi.org/10.1186/s13287-021-02483-7 Cite
