MaxiVAX SA and Minaris Regenerative Medicine GmbH have entered into a manufacturing agreement for MVX-ONCO-2, a cell-based immunotherapy for the treatment of cancers such as chordoma, head and neck, and other solid tumors.
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Researchers demonstrated that CD20 controlled the nanoscale organization of receptors on the surface of resting B lymphocytes.
[Proceedings of the National Academy of Sciences of the United States of America]
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Kläsener, K., Jellusova, J., Andrieux, G., Salzer, U., Böhler, C., Steiner, S. N., Albinus, J. B., Cavallari, M., Süß, B., Voll, R. E., Boerries, M., Wollscheid, B., & Reth, M. (2021). CD20 as a gatekeeper of the resting state of human B cells. Proceedings of the National Academy of Sciences, 118(7). https://doi.org/10.1073/pnas.2021342118 Cite
Scientists summarize recent studies investigating the involvement of TAMs in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies.
[Signal Transduction and Targeted Therapy]
Integrative analysis identified 117 p30-dependent REs associated with 33 strongly down-regulated genes upon p30-knockdown. CRISPR/Cas9-mediated mutational disruption of these genes revealed the RNA-binding protein MSI2 as a critical p30-target.
Scientists established a procedure for placental HSC transplantation into E11.5 Runx1-deficient mice mated with G1-HRD-Runx1 transgenic mice that had no HSCs in the fetal liver.
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Jeon, H., Asano, K., Wakimoto, A., Kulathunga, K., Tran, M. T. N., Nakamura, M., Yokomizo, T., Hamada, M., & Takahashi, S. (2021). Generation of reconstituted hemato-lymphoid murine embryos by placental transplantation into embryos lacking HSCs. Scientific Reports, 11(1), 4374. https://doi.org/10.1038/s41598-021-83652-9 Cite
Using T cell bispecific antibodies and chimeric antigen receptors directed against HER2, scientists showed that disruption of interferon-gamma signaling confers resistance to killing by active T lymphocytes.
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Arenas, E. J., Martínez-Sabadell, A., Rius Ruiz, I., Román Alonso, M., Escorihuela, M., Luque, A., Fajardo, C. A., Gros, A., Klein, C., & Arribas, J. (2021). Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nature Communications, 12(1), 1237. https://doi.org/10.1038/s41467-021-21445-4 Cite
Scientists report the development of novel engineered recombinant adeno‐associated virus vectors that enabled efficient targeting of photoreceptors via less invasive intravitreal administration.
[EMBO Molecular Medicine]
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Pavlou, M., Schön, C., Occelli, L. M., Rossi, A., Meumann, N., Boyd, R. F., Bartoe, J. T., Siedlecki, J., Gerhardt, M. J., Babutzka, S., Bogedein, J., Wagner, J. E., Priglinger, S. G., Biel, M., Petersen-Jones, S. M., Büning, H., & Michalakis, S. (2021). Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders. EMBO Molecular Medicine, n/a(n/a), e13392. https://doi.org/10.15252/emmm.202013392 Cite
Therapeutic Solutions International, Inc., reported novel data and filing of a patent application demonstrating that StemVacs™ cells carrying proprietary sequences from the cancer-specific antigen Brother of the Regulator of Imprinted Sites, were able to elicit the generation of T cells capable of selectively killing cancer stem cells.
[Therapeutic Solutions International, Inc. (PR Newswire)]
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In November 2020, the FDA granted Regenerative Medicine Advanced Therapy designation for a cellular therapy called AB-205. AB-205 acts promptly to repair injured vascular niches of organs to prevent or reduce severe toxicities in patients who have Hodgkin lymphoma or non-Hodgkin lymphoma undergoing high dose chemotherapy and autologous stem cell transplantation.
[Hackensack University Medical Center (Newswise, Inc.)]
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The authors showed that expression of the glucagon-like peptide-1 gene delivered by epidermal stem cells attenuated development and reinstatement of alcohol-induced drug-taking and seeking as well as voluntary oral alcohol consumption.
Researchers report a case of irreversible B cell maturation antigen (BCMA) loss in a patient with multiple myeloma who was enrolled in the KarMMa trial and progressed after anti-BCMA CAR T cell therapy.
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Da Vià, M. C., Dietrich, O., Truger, M., Arampatzi, P., Duell, J., Heidemeier, A., Zhou, X., Danhof, S., Kraus, S., Chatterjee, M., Meggendorfer, M., Twardziok, S., Goebeler, M.-E., Topp, M. S., Hudecek, M., Prommersberger, S., Hege, K., Kaiser, S., Fuhr, V., … Rasche, L. (2021). Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma. Nature Medicine, 1–4. https://doi.org/10.1038/s41591-021-01245-5 Cite