Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Cellular Uptake and In Vivo Distribution of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles Are Protein Corona Dependent

[Nature Nanotechnology] Scientists explored the impact of protein corona on extracellular vesicles (EVs) derived from two culturing conditions in which specific proteins acquired from media were simultaneously adsorbed on the EV surface.

Targeting the Mevalonate or Wnt Pathways to Overcome CAR T-Cell Resistance in TP53-Mutant AML Cells

[EMBO Molecular Medicine] The authors showed that CAR T-cells engaging TP53-deficient leukemia cells exhibited a prolonged interaction time, upregulated exhaustion markers, and were inefficient to control acute myeloid leukemia (AML) cell outgrowth in vitro and in vivo compared to TP53 wild-type cells.

Engineering Transcriptional Regulation for Cell-Based Therapies

[SLAS Technology] Investigators examine current engineering approaches to control transcription in mammalian cells with an emphasis on systems that can be selectively activated in response to extracellular signals.

Lineage Announces FDA Clearance of IND Amendment for OPC1 Cell Transplant for the Treatment of Spinal Cord Injury

[Lineage Cell Therapeutics, Inc.] Lineage Cell Therapeutics, Inc. announced the clearance, by the FDA, of its Investigational New Drug amendment for OPC1, an investigational allogeneic oligodendrocyte progenitor cell transplant for the treatment of spinal cord injury.

Tough Physically Crosslinked Poly(vinyl Alcohol)-Based Hydrogels Loaded With Collagen Type I to Promote Bone Regeneration In Vitro and In Vivo

[International Journal Of Biological Macromolecules] Investigators developed a tough Poly(vinyl alcohol) (PVA)-based hydrogel using a facile physical crosslinking method, comprising of PVA, tannic acid (TA), and hydroxyapatite (HA). Systematic experiments were conducted to examine the physicochemical properties of PVA/HA/TA hydrogels, including their compositions, microstructures, and mechanical and rheological properties.

Host Brain Environmental Influences on Transplanted Medial Ganglionic Eminence Progenitors

[Scientific Reports] Investigators systematically evaluated the influence of age and brain region on survival, migration, and differentiation of transplant-derived cells.

4D Printed Shape-Shifting Biomaterials for Tissue Engineering and Regenerative Medicine Applications

[Biofabrication] Scientists present an overview of the current developments of the 4D printing technology for tissue engineering and regenerative medicine, with a focus on approaches to achieve temporal changes of the shape of the printed constructs that would enable biofabrication of highly complex structures.

Hypoimmune Islets Achieve Insulin Independence After Allogeneic Transplantation in a Fully Immunocompetent Non-Human Primate

[Cell Stem Cell] Investigators reported that allogeneic transplantation of genetically engineered, primary, hypoimmune, pseudo-islets resulted in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provided stable endocrine function and enabled insulin independence without inducing any detectable immune response in the absence of immunosuppression.

CAR-T Cell Therapy Targeting Surface Expression of TYRP1 to Treat Cutaneous and Rare Melanoma Subtypes

[Nature Communications] Investigators identified Tyrosinase Related Protein 1 as a CAR-T cell therapy target to treat patients with cutaneous and rare melanoma subtypes unresponsive to immune checkpoint blockade.

Cell Membrane-Targeting Type I/II Photodynamic Therapy Combination with FSP1 Inhibition for Ferroptosis-Enhanced Photodynamic Immunotherapy

[Advanced Healthcare Materials] Scientists developed a cell membrane-targeting photosensitizer, TBzT-CNQi, which could generate 1O2, •OH, and O2•− via type I/II process to induce a high level of lipid peroxide for potent ferroptosis and photodynamic therapy.

Gene Therapy With AAV9-SGPL1 in an Animal Model of Lung Fibrosis

[Journal Of Pathology] Researchers found that a knock-in mouse with a missense S1P lyase (SPL) mutation mimicking human disease resulted in reduced SPL activity, increased S1P, increased TGF-β signaling, increased lung fibrosis, and higher mortality after injury compared to wild type.

FLT3L-Induced Virtual Memory CD8 T Cells Engage the Immune System Against Tumors

[Journal Of Biomedical Science] Albumin-conjugated FLT3L (Alb-FLT3L) was generated and applied for translational medicine purposes; here it was used to treat naïve C57BL/6 and OT1 mice for CD8 T cell response analysis. Syngeneic B16ova and E.G7ova mouse models were employed for adoptive cell transfer to evaluate the effects of Alb-FLT3L preconditioning of CD8 T cells on tumor progression.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.