Suprachoroidal Gene Transfer with Nonviral Nanoparticles

Suprachoroidal injection of nanoparticles containing a VEGF-binding protein expression plasmid significantly suppressed VEGF-induced vascular leakage and neovascularization demonstrating therapeutic potential.
[Science Advances]
Shen, J., Kim, J., Tzeng, S. Y., Ding, K., Hafiz, Z., Long, D., … Campochiaro, P. A. (2020). Suprachoroidal gene transfer with nonviral nanoparticles. Science Advances, 6(27), eaba1606. https://doi.org/10.1126/sciadv.aba1606 Cite
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Current Progress in Stem Cell Therapy for Type 1 Diabetes Mellitus

Researchers discuss the current research advances in strategies to obtain insulin-producing cells from different precursor cells and in stem cell-based therapies for diabetes.
[Stem Cell Research & Therapy]
Chen, S., Du, K., & Zou, C. (2020). Current progress in stem cell therapy for type 1 diabetes mellitus. Stem Cell Research & Therapy, 11(1), 275. https://doi.org/10.1186/s13287-020-01793-6 Cite
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‘I Feel Like I Am Not Welcome’: Medical, Doctoral Students from Abroad Grapple with Uncertainty from New ICE Rules

International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT]
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Phase I Dose Escalation Study of Naive T-Cell Depleted Donor Lymphocyte Infusion following Allogeneic Stem Cell Transplantation

In this Phase I dose escalation study, the authors assessed the safety of a donor lymphocyte infusion that was depleted of CD45RA+ naive T cells.
[Bone Marrow Transplantation]
Maung, K. K., Chen, B. J., Barak, I., Li, Z., Rizzieri, D. A., Gasparetto, C., … Horwitz, M. E. (2020). Phase I dose escalation study of naive T-cell depleted donor lymphocyte infusion following allogeneic stem cell transplantation. Bone Marrow Transplantation, 1–7. https://doi.org/10.1038/s41409-020-0991-5 Cite
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Endothelial Progenitor Cell Transplantation Restores Vascular Injury in Mice after Whole-brain Irradiation

Flow cytometry demonstrated that irradiation led to a significant reduction in the peripheral blood endothelial progenitor cell (EPC) count; however, EPC transplantation led to a significant increase in the circulating EPCs.
[Brain Research]
Huang, X., Li, M., Zhou, D., Deng, Z., Guo, J., & Huang, H. (2020). Endothelial Progenitor Cell Transplantation Restores Vascular Injury in Mice after Whole-brain Irradiation. Brain Research, 147005. https://doi.org/10.1016/j.brainres.2020.147005 Cite
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Long-Term Outcomes of Cultivated Cell Sheet Transplantation for Treating Total Limbal Stem Cell Deficiency

This study was conducted to determine the long-term outcomes of cultivated cell sheet transplantation, and to clarify risk factors that affected the outcomes.
[Ocular Surface]
Shimazaki, J., Satake, Y., Higa, K., Yamaguchi, T., Noma, H., & Tsubota, K. (2020). Long-term outcomes of cultivated cell sheet transplantation for treating total limbal stem cell deficiency. The Ocular Surface. https://doi.org/10.1016/j.jtos.2020.06.005 Cite
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Treatment with shCCL20-CCR6 Nanodendriplexes and Human Mesenchymal Stem Cell Therapy Improves Pathology in Mice with Repeated Traumatic Brain Injury

Researchers developed a combined nano-cell therapy by using dendrimers complexed with plasmids targeting CCL20 and its sole receptor CCR6 to reduce inflammation followed by human mesenchymal stem cell transplantation.
[Nanomedicine-Nanotechnology Biology and Medicine]
Mayilsamy, K., Markoutsa, E., Das, M., Chopade, P., Puro, D., Kumar, A., … Mohapatra, S. (2020). Treatment with shCCL20-CCR6 nanodendriplexes and human mesenchymal stem cell therapy improves pathology in mice with repeated traumatic brain injury. Nanomedicine: Nanotechnology, Biology and Medicine, 102247. https://doi.org/10.1016/j.nano.2020.102247 Cite
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Transplantation of Human Urine-Derived Neural Progenitor Cells after Spinal Cord Injury in Rats

Using a rat contusive spinal cord injury model, scientists evaluated the survival, migration and differentiation of urine derived induced pluripotent stem cell-neural progenitor cells after transplantation at subacute phase.
[Neuroscience Letters]
Liu, A., Kang, S., Yu, P., Shi, L., & Zhou, L. (2020). Transplantation of human urine-derived neural progenitor cells after spinal cord injury in rats. Neuroscience Letters, 135201. https://doi.org/10.1016/j.neulet.2020.135201 Cite
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DLL4 Restores Damaged Liver by Enhancing hBMSC Differentiation into Cholangiocytes

Scientists aimed to determine whether human bone marrow mesenchymal stem cells can differentiate into biliary epithelial cells in vitro and in vivo and to clarify the role of delta-like ligand 4 (DLL4) in restoring damaged liver by enhancing cholangiocyte differentiation.
[Stem Cell Research]
Sun, S., Yuan, L., An, Z., Shi, D., Xin, J., Jiang, J., … Li, J. (2020). DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes. Stem Cell Research, 47, 101900. https://doi.org/10.1016/j.scr.2020.101900 Cite
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Lung Delivery of MSCs Expressing Anti-Cancer Protein TRAIL Visualized with 89Zr-Oxine PET-CT

Investigators demonstrated 89Zr-oxine labeling and PET-CT imaging as a potential clinical solution for non-invasively tracking MSCTRAIL biodistribution
[Stem Cell Research & Therapy]
Patrick, P. S., Kolluri, K. K., Zaw Thin, M., Edwards, A., Sage, E. K., Sanderson, T., … Kalber, T. L. (2020). Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT. Stem Cell Research & Therapy, 11(1), 256. https://doi.org/10.1186/s13287-020-01770-z Cite
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AVROBIO Announces New Patients Dosed in Gaucher Disease and Cystinosis Clinical Trials

AVROBIO, Inc. announced that the first patient has been dosed in the company’s GuardOne clinical trial, a Phase I/II investigational study evaluating AVR-RD-02 for Gaucher disease type 1.
[AVROBIO, Inc.]
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Celixir Provides Update on Ongoing Clinical Program with Lead Therapeutic Candidate CLXR-001

Celixir announced an update to its ongoing clinical programme with lead therapeutic candidate CLXR-001.
[Celixir (GlobeNewswire, Inc.)]
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