Government of Canada and JDRF Canada Announce New Research Funding to Accelerate Stem Cell-Based Therapies for Type 1 Diabetes

To mark the end of Diabetes Awareness Month, Sonia Sidhu, Member of Parliament for Brampton South, on behalf of the Honourable Patty Hajdu, Minister of Health, announced an investment of $6 million through the CIHR-JDRF Partnership to Defeat Diabetes for two Canadian research teams to accelerate the development of stem cell-based therapies for the treatment of type 1 diabetes.
[Juvenile Diabetes Research Foundation]
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Genprex Initiates Site Recruitment for Acclaim-1 Clinical Trial for the Treatment of Non-Small Cell Lung Cancer

Genprex, Inc. announced it has commenced clinical trial site recruitment for its upcoming Acclaim-1 clinical trial for the treatment of non-small cell lung cancer. Acclaim-1 is an open-label, multi-center Phase 1/2 clinical trial that combines Genprex’s lead drug candidate, REQORSA™ immunogene therapy with AstraZeneca PLC’s Tagrisso.
[Genprex, Inc.]
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The Clinical Role of the Gut Microbiome and Fecal Microbiota Transplantation in Allogeneic Stem Cell Transplantation

The authors define the role of administrating fecal microbiota transplantation in the setting of allogeneic hematopoietic stem cell transplantation.
[Haematologica]
Henig, I., Yehudai-Ofir, D., & Zuckerman, T. (2020). The clinical role of the gut microbiome and fecal microbiota transplantation in allogeneic stem cell transplantation. Haematologica. https://doi.org/10.3324/haematol.2020.247395 Cite
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Detection of Immunogenic Cell Death and Its Relevance for Cancer Therapy

Scientists outline methodological approaches for measuring immunogenic cell death markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer regimens, and the identification of optimal therapeutic combinations for the clinical management of cancer.
[Cell Death & Disease]
Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020). Detection of immunogenic cell death and its relevance for cancer therapy. Cell Death & Disease, 11(11), 1–13. https://doi.org/10.1038/s41419-020-03221-2 Cite
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Targeting the Endothelin Axis as a Therapeutic Strategy for Oral Cancer Metastasis and Pain

Scientists demonstrated that combination treatment of macitentan and ETBR gene therapy inhibited invasion, but not proliferation, in cell culture and in a mouse model of tongue cancer.
[Scientific Reports]
Targeting the endothelin axis as a therapeutic strategy for oral cancer metastasis and pain | Scientific Reports. (n.d.). Retrieved November 30, 2020, from https://www.nature.com/articles/s41598-020-77642-6 Cite
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Fabrication of Hyaline-Like Cartilage Constructs using Mesenchymal Stem Cell Sheets

Researchers developed transplantable hyaline-like cartilage constructs by stimulating MSC chondrogenic differentiation as cell sheets.
[Scientific Reports]
Thorp, H., Kim, K., Kondo, M., Grainger, D. W., & Okano, T. (2020). Fabrication of hyaline-like cartilage constructs using mesenchymal stem cell sheets. Scientific Reports, 10(1), 20869. https://doi.org/10.1038/s41598-020-77842-0 Cite
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Therapeutic Efficacy of Umbilical Cord-Derived Stem Cells for Diabetes Mellitus: A Meta-Analysis Study

The clinical efficacy was evaluated based on glycemic control status and β cell function, as well as the daily insulin requirement in diabetic patients after receiving umbilical cord-derived stem cell-transplantation compared to baseline values.
[Stem Cell Research & Therapy]
Kassem, D. H., & Kamal, M. M. (2020). Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study. Stem Cell Research & Therapy, 11(1), 484. https://doi.org/10.1186/s13287-020-01996-x Cite
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Lonza and Be The Match BioTherapies Partner to Expand Vein-to-Vein Cell and Gene Therapy Supply Chain Network

Be The Match BioTherapies as a preferred partner to provide consistent access to high-quality, healthy donor tissue and cell and gene therapy supply chain support.
[Be The Match BioTherapies]
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The Gut Microbiota Is Associated with Immune Cell Dynamics in Humans

Researchers study hundreds of hospitalized—and closely monitored—patients with cancer receiving haematopoietic cell transplantation as they recover from chemotherapy and stem-cell engraftment.
[Nature]
Schluter, J., Peled, J. U., Taylor, B. P., Markey, K. A., Smith, M., Taur, Y., Niehus, R., Staffas, A., Dai, A., Fontana, E., Amoretti, L. A., Wright, R. J., Morjaria, S., Fenelus, M., Pessin, M. S., Chao, N. J., Lew, M., Bohannon, L., Bush, A., … Xavier, J. B. (2020). The gut microbiota is associated with immune cell dynamics in humans. Nature, 1–5. https://doi.org/10.1038/s41586-020-2971-8 Cite
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Establishment of Human Fetal Hepatocyte Organoids and CRISPR–Cas9-Based Gene Knockin and Knockout in Organoid Cultures from Human Liver

Scientists established culture conditions that facilitate long-term expansion of human fetal hepatocytes as organoids
[Nature Protocols]
Hendriks, D., Artegiani, B., Hu, H., Chuva de Sousa Lopes, S., & Clevers, H. (2020). Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver. Nature Protocols, 1–36. https://doi.org/10.1038/s41596-020-00411-2 Cite
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Innate and Innate-Like Cells: The Future of Chimeric Antigen Receptor (CAR) Cell Therapy

Scientists review the applicability of these cells in the context of CAR therapy, focusing on therapies under development, the advantages of these approaches relative to conventional CAR-T cells, and their potential in allogeneic therapies.
[Trends in Pharmacological Sciences]
Cortés-Selva, D., Dasgupta, B., Singh, S., & Grewal, I. S. (2020). Innate and Innate-Like Cells: The Future of Chimeric Antigen Receptor (CAR) Cell Therapy. Trends in Pharmacological Sciences, 0(0). https://doi.org/10.1016/j.tips.2020.11.004 Cite
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