Cell Therapy News | Science News

Enhancement of CAR-T Cell Activity against Cholangiocarcinoma by Simultaneous Knockdown of Six Inhibitory Membrane Proteins

June 8, 2023

[Cancer Communications] Researchers knocked down immune checkpoints and immunosuppressive molecular receptors in CAR-T cells by constructing two clusters of small hairpin RNAs and evaluated the engineered CAR-T cells for antitumor activity both in vitro, using tumor cell lines and cholangiocarcinoma organoid models, and in vivo, using humanized mouse models.

Unrelated or Haploidentical Allogeneic Hematopoietic Cell Transplantation in Second Complete Remission for Acute Myeloid Leukemia—Improved Outcomes Over Time: A European Society for Blood and...

June 6, 2023

[Cancer] Even in the absence of a matched sibling donor, outcomes of allogeneic hematopoietic cell transplantation in second complete remission for acute myeloid leukemia have significantly improved over time, with most favorable outcomes achieved with matched unrelated donors.

US DoD Funds Stem Cell Research for Severe Traumatic Brain Injury

June 6, 2023

[The Defense Post] The US Department of Defense (DoD) has awarded UTHealth Houston a $4.9 million contract to research if stem cells reduce chronic neuroinflammatory response to severe traumatic brain injury in warfighters.

‘It’s a Vote for Hope’: First Gene Therapy for Muscular Dystrophy Nears Approval, but Will It Work?

June 5, 2023

[Imbria Pharmaceuticals, Inc.] Imbria Pharmaceuticals, Inc. announced that it has completed enrollment in the IMPROVE-HCM Phase II placebo-controlled clinical trial of ninerafaxstat with 67 patients with non-obstructive hypertrophic cardiomyopathy randomized.

Dual Human iPSC-Derived Cardiac Lineage Cell-Seeding Extracellular Matrix Patches Promote Regeneration and Long-Term Repair of Infarcted Hearts

June 5, 2023

[Bioactive Materials] Scientists demonstrated the efficacy and mechanisms of mono- and dual-human pluripotent stem cell-derived cardiovascular progenitor cells- and cardiomyocytes-seeding small intestinal submucosal extracellular matrix for repair of infarcted hearts based on the side-by-side comparison.

Exploratory Study on the Efficacy of Bortezomib Combining Mitoxantrone or CD22-CAR T Therapy Targeting CD19-Negative Relapse After CD19-CAR T Cell Therapy With a Simpler...

June 5, 2023

[Apoptosis] Investigators established a cellular model system using a CD19-positive B lineage acute lymphoblastic leukemia (B-ALL) cell line Nalm-6 to investigate the treatment options for CD19-negative relapsed B-ALL after CD19-CAR T cell therapy.

A Novel Autologous CAR-T Therapy, YTB323, With Preserved T-Cell Stemness Shows Enhanced CAR T-Cell Efficacy in Preclinical and Early Clinical Development

June 5, 2023

[Cancer Discovery] In preclinical mouse models, YTB323, a novel autologous CD19-directed CAR T-cell therapy expressing the same validated CAR as tisagenlecleucel, exhibited enhanced in vivo expansion and antitumor activity at lower doses than traditionally manufactured CAR T-cells.

Lysophosphatidic Acid Modulates CD8 T Cell Immunosurveillance and Metabolism To Impair Anti-Tumor Immunity

June 5, 2023

[Nature Communications] Lysophosphatidic acid receptor signaling by CD8 T cells promoted tolerogenic states via metabolic reprogramming and potentiating exhaustive-like differentiation to modulate anti-tumor immunity.

Developing Hypoimmunogenic Human iPSC-Derived Oligodendrocyte Progenitor Cells as an Off-the-Shelf Cell Therapy for Myelin Disorders

June 5, 2023

[Advanced Science] Hypoimmunogenic iPSCs were generated through CRISPR/Cas9 editing of the human leukocyte antigen molecules in healthy donor-derived iPSCs and differentiated into oligodendrocyte progenitor cells (OPCs_. The OPCs were engrafted into the brains of Canavan disease mice and exhibited widespread distribution in the brain.

Unrelated or Haploidentical Allogeneic Hematopoietic Cell Transplantation in Second Complete Remission for Acute Myeloid Leukemia—Improved Outcomes Over Time: A European Society for Blood and...

June 5, 2023

[Cancer] Even in the absence of a matched sibling donor, outcomes of allogeneic hematopoietic cell transplantation in second complete remission for acute myeloid leukemia have significantly improved over time, with most favorable outcomes achieved with matched unrelated donors.

Activation-Inducible CAR Expression Enables Precise Control Over Engineered CAR T Cell Function

June 5, 2023

[Communications Biology] Scientists manufactured activation-inducible CAR T cells with the help of CRISPR-mediated targeted integration. This new type of engineered T cells expressed the CAR gene dependent on their activation status.

Efficient Chimeric Antigen Receptor (CAR) Targeting of a Central Epitope of CD22

June 5, 2023

[Journal Of Biological Chemistry] Researchers compared m971-CAR with a novel CAR derived from IS7, an antibody that targets a central epitope on CD22. The IS7-CAR has superior avidity, and is active and specific against CD22 positive targets, including B lineage acute lymphoblastic leukemia patient-derived xenograft samples.