Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Stem Cell-Based Therapy for Human Diseases

[Signal Transduction and Targeted Therapy] Scientists provide an update on recent clinical applications using either human pluripotent stem cells or mesenchymal stem cells derived from bone marrow, adipose tissue, or the umbilical cord for the treatment of human diseases.

Extracellular Vesicles Derived from Wharton’s Jelly Mesenchymal Stem Cells Inhibit the Tumor Environment via the miR-125b/HIF1α Signaling Pathway

[Scientific Reports] The authors suggested a novel strategy to treat triple negative breast cancer (TNBC) using mesenchymal stem cell-derived extracellular vesicles to transform the behaviors and cellular communication of TNBC cells with other non-cancer cells related to tumorigenesis and metastasis.

Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T Cell Immunotherapy against Cancer

[Cancer Discovery] Researchers combined CAR T19 with the FDA-approved BCL-2-inhibitor, venetoclax, and demonstrated in vivo synergy in venetoclax-sensitive non-Hodgkin lymphoma.

Rearrangement of T Cell Genome Architecture Regulates GVHD

[iScience] Wapl deficiency in T cells reduced loop extensions, changed expression of cell cycling genes, reduced proliferation following in vitro and in vivo stimulation, and reduced severity of graft-versus-host disease following experimental allogeneic hematopoietic stem cell transplantation.

Off-The-Shelf Third-Party HSC-Engineered iNKT Cells for Ameliorating GvHD While Preserving GvL Effect in the Treatment of Blood Cancers

[iScience] Scientists reported the successful generation of third-party hematopoietic stem cell (HSC)-engineered human invariant natural killer T (iNKT) cells, using a method combining HSC gene engineering and in vitro HSC differentiation.

Stem Cell Transplantation for Systemic Sclerosis

[Cochrane Database of Systematic Reviews] Scientists assess the benefits and harms of autologous hematopoietic stem cell transplantation for the treatment of systemic sclerosis.

UK Charity Gives $36 Million Boost to Gene Editing for Inherited Heart Diseases

[ScienceInsider] In the biggest research grant ever from the research charity, the British Heart Foundation announced an award of £30 million over five years to an international team to develop gene-editing treatments for deadly heart conditions.

R-spondin3 Is a Myokine That Differentiates Myoblasts to Type I Fibres

[Scientific Reports] To examine whether Rspo3 induced type I fibres, primary myoblasts prepared from mouse soleus muscles were exposed to a differentiation medium containing the mouse recombinant Rspo3 protein.

Targeting Transcription in Heart Failure via CDK7/12/13 Inhibition

[Nature Communications] Researchers demonstrated that CDK7/12/13 were critical regulators of transcription activation in the heart that could be pharmacologically inhibited to improve heart failure with reduced ejection fraction.

Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes

[Circulation Research] Researchers clarified the pathophysiological significance of lysine crotonylation in cardiac injury and explored the underlying mechanism.

Dysregulation of Tweak and Fn14 in Skeletal Muscle of Spinal Muscular Atrophy Mice

[Skeletal Muscle] Researchers investigated the potential role of the TWEAK/Fn14 pathway in spinal muscular atrophy muscle pathology. They also used experimental models of denervation and muscle injury in pre-weaned wild-type animals and siRNA-mediated knockdown in C2C12 muscle cells to conduct additional mechanistic investigations.

Myocardin Regulates Exon Usage in Smooth Muscle Cells Through Induction of Splicing Regulatory Factors

[Cellular and Molecular Life Sciences] Researchers identified four splicing factors (MBNL1, RBPMS, RBPMS2, and RBFOX2) that correlated with myocardin across human smooth muscle cell tissues.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.