An NK-Like CAR T Cell Transition in CAR T Cell Dysfunction

Researchers identified a gene signature defining CAR and TCR dysregulation and transcription factors, including SOX4 and ID3 as key regulators of CAR T cell exhaustion.
[Cell]
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Genetic Ablation of PRDM1 in Antitumor T Cells Enhances Therapeutic Efficacy of Adoptive Immunotherapy

Scientists identified PR domain zinc finger protein 1 (PRDM1) i.e., Blimp-1, as a key epigenetic gene associated with terminal T cell differentiation.
[Blood]
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Natural Killer Cells and Immune-Checkpoint Inhibitor Therapy: Current Knowledge and New Challenges

Scientists overview and discuss this new perspective, focusing on the most relevant candidates for this role among the variety of potential NK immune checkpoints.
[Molecular Therapy-Oncolytics]
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MSCs and Their Exosomes: A Rapidly Evolving Approach in the Context of Cutaneous Wounds Therapy

Scientists summarize on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports.
[Stem Cell Research & Therapy]
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In Vivo Genome-Wide CRISPR Screens Identify SOCS1 as Intrinsic Checkpoint of CD4+ TH1 Cell Response

Researchers showed that SOCS1 was a critical node integrating both IL-2 and IFN-γ signals to block multiple downstream signaling pathways abrogating CD4+ T helper 1 (TH1) cell response.
[Science Immunology]
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Cancer-Cell Stiffening via Cholesterol Depletion Enhances Adoptive T Cell Immunotherapy

The authors showed that T cell-mediated cancer-cell killing was hampered for cortically soft cancer cells, which have plasma membranes enriched in cholesterol.
[Nature Biomedical Engineering]
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Implanted Pluripotent Stem-Cell-Derived Pancreatic Endoderm Cells Secrete Glucose-Responsive C-peptide in Patients with Type 1 Diabetes

The authors reported an analysis on one year of data from the first cohort of 15 patients from a single trial site that received subcutaneous implantation of cell products combined with an immunosuppressive regimen.
[Cell Stem Cell]
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α1-Adrenergic Receptor Mediates Adipose-Derived Stem Cell Sheet-Induced Protection against Chronic Heart Failure after Myocardial Infarction in Rats

Hypoxia increased α1-AR and vascular endothelial growth factor (VEGF) mRNA levels in adipose-derived stem cells. Norepinephrine further increased VEGF mRNA expression under hypoxia; this effect was abolished by doxazosin.
[Hypertension Research]
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Impact of Donor-Derived CD34+ Infused Cell Dose on Outcomes of Patients Undergoing Allo-HCT Following Reduced Intensity Regimen for Myelofibrosis: A Study from the Chronic Malignancies Working Party of the EBMT

Investigators retrospectively analyzed 657 patients with primary or secondary myelofibrosis transplanted with use of peripheral blood stem cells after fludarabine/melphalan or fludarabine/busulfan RIC regimen.
[Bone Marrow Transplantation]
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$4M Grant Will Help To Advance New CAR T-Cell Therapy

The California Institute for Regenerative Medicine governing board approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T-cell therapy from the laboratory into the clinic.
[Technology Networrks]
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Oncolytic Adenovirus-Mediated Expression of Decorin Facilitates CAIX-Targeting CAR-T Therapy against Renal Cell Carcinoma

Investigators combinated an oncolytic adenovirus carrying Decorin with a CAR-T targeting carbonic anhydrase IX to perform the anti-tumor activity for renal cancer cells.
[Molecular Therapy-Oncolytics]
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