Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Lipid Nanoparticle (LNP) Mediated mRNA Delivery in Cardiovascular Diseases: Advances in Genome Editing and CAR T Cell Therapy

[Journal of Controlled Release] Investigators conclude that the strategies to facilitate the extra-hepatic delivery and targeted organ tropism of mRNA-lipid nanoparticles (LNPs) hold great prospects to accelerate the development and translation of mRNA-LNPs in cardiovascular disease treatment.

Microglia Protect Against Age-Associated Brain Pathologies

[Neuron] Investigators examined the consequences of permanent microglial deficiencies on brain aging using the Csf1rΔFIRE/ΔFIRE mouse model. In juvenile Csf1rΔFIRE/ΔFIRE mice, they showed that microglia were dispensable for the transcriptomic maturation of other brain cell types.

Gene Therapy for CNS Disorders: Modalities, Delivery and Translational Challenges

[Nature Reviews Neuroscience] The authors provide an overview of gene therapy modalities for central nervous system diseases, emphasizing the interconnectedness of different delivery strategies and routes of administration.

Knocking Out CD70 Rescues CD70-Specific nanoCAR T Cells from Antigen-Induced Exhaustion

[Cancer Immunology Research] Investigators evaluated the nanoCARs in clinically relevant models in vitro, using co-cultures of CD70-specific nanoCAR T cells with malignant rhabdoid tumor organoids, and in vivo, using a diffuse large B cell lymphoma patient-derived xenograft model.

Immuno-Protective Vesicle-Crosslinked Hydrogel for Allogenic Transplantation

[Nature Communications] The authors reported a local immuno-protective strategy to enhance post-transplant persistence of allografts using a MSC membrane-derived vesicle-crosslinked hydrogel.

$2.9M Research Grant Funds Technology for MS Stem Cell Therapy

[Multiple Sclerosis News Today] The National Institute of Neurological Disorders and Stroke has awarded a $2.9 million, five-year grant to a research project that aims to advance a new technology that could improve stem cell therapies for multiple sclerosis (MS) and other neurological disorders.

CRISPR-Mediated Sox9 Activation and RelA Inhibition Enhance Cell Therapy for Osteoarthritis

[Molecular Therapy] Researchers used Sox9 activation and RelA inhibition, both mediated by the CRISPR/dCas9 technology simultaneously, to engineer MSCs with enhanced chondrogenic potential and downregulated inflammatory responses.

Thymidylate Synthase Disruption to Limit Cell Proliferation in Cell Therapies

[Molecular Therapy] The authors described a safety system to control cell proliferation while allowing robust and efficient cell manufacture, without any added genetic elements. Inactivating TYMS, a key nucleotide metabolism enzyme, in several cell lines resulted in cells that proliferate only when supplemented with exogenous thymidine.

Intravenous Application of Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuropathic Pain by Suppressing Microglia Activation in Rats

[Heliyon] Scientists verified the analgesic effect of intravenous administration of human umbilical cord mesenchymal stem cells upon rats with chronic constriction injury-induced neuropathic pain and the concomitant mechanism via modulating microglia.

Stromal Cells Engineered to Express T Cell Factors Induce Robust CLL Cell Proliferation In Vitro and in PDX Co-Transplantations Allowing the Identification of RAF...

[Leukemia] Investigators prepared a novel model based on mimicking T cell signals in vitro and in patient-derived xenografts. Six supportive cell lines were prepared by engineering HS5 stromal cells with stable expression of human CD40L, IL4, IL21, and their combinations.

Seraxis Wins Maryland Stem Cell Research Fund Grant to Accelerate Development of Allogenetically Compatible Pancreatic Islet Replacement Therapy for Functional Cure of T1D

[Seraxis (Newswire)] Seraxis, Inc., a regenerative medicine company developing pancreatic islet replacement therapies to transform the lives of patients with Type 1 and insulin-requiring Type 2 diabetes, has been notified that the company is the awardee of a $400,000 Commercialization Program grant from the Maryland Stem Cell Research Fund that aims to foster Maryland research to enhance and propel stem cell treatments.

Virus Specific T Cell Therapy to Treat Refractory Viral infections in Solid Organ Transplant Recipients

[American Journal of Transplantation] The authors provide a state-of-the-art update of the current virus specific T cell pipeline and translational research that is likely to lead to further treatment options for viral infections in solid organ transplant recipients.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.