Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Oxidative Stress-Induced Senescence in Endothelial Cells via Regulation of miR-146a/Src

In vitro results showed that MSC-small extracellular vesicles reduced senescent biomarkers, decreased senescence-associated secretory phenotype, rescued angiogenesis, migration and other dysfunctions in senescent endothelial cell induced by oxidative stress.
[Signal Transduction and Targeted Therapy]
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Promise and Pitfalls of Allogeneic Chimeric Antigen Receptor Therapy in Plasma Cell and Lymphoid Malignancies

Investigators provide a comprehensive review of the challenges associated with autologous CAR, the benefits and potential challenges associated with allogenic-CAR.
[British Journal of Haematology]
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BioCardia Announces First Patient Treated in CardiAMP Cell Therapy Trial for Chronic Myocardial Ischemia

BioCardia®, Inc. announced the treatment of the first patient in its Phase III pivotal CardiAMP Cell Therapy Chronic Myocardial Ischemia Trial for patients with no option chronic myocardial ischemia with refractory angina.
[BioCardia®, Inc.]
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Longeveron Announces Activation of Two New Clinical Sites in ELPIS II Trial of Lomecel-B for Hypoplastic Left Heart Syndrome (HLHS)

Longeveron, Inc. announced the activation of two new clinical sites for the currently enrolling ELPIS II Trial, evaluating Lomecel-B injection into the myocardium of infants with Hypoplastic Left Heart Syndrome, a rare and life-threatening congenital heart defect.
[Longeveron, Inc.]
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SynGAP Research Fund Announces $308,000 Multidisciplinary Biomarker Grant to Boston Children’s Hospital

The SynGAP Research Fund (SRF) announces grants to Drs. April Levin, Mustafa Sahin and Annapurna Poduri of Boston Children’s Hospital to advance SYNGAP1 biomarker characterization and genotype-phenotype analysis.
[SynGAP Research Fund]
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Ambulero’s Gene Therapy Candidate AMB-301 Granted US Orphan Drug Designation for Treatment of Severe Vascular Disease

Ambulero, Inc. announced that the US FDA’s Office For Orphan Products Development granted the company’s request for orphan drug status for its gene therapy candidate, AMB-301, to treat Buerger’s Disease, also known as Thromboangiitis Obliterans.
[Ambulero, Inc.]
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Combining Systemic and Locally Applied Cellular Therapies for the Treatment of Systemic Sclerosis

Investigators provide an overview of the cellular therapies available for the management of systemic sclerosis, including systemically injected therapies and locally administered regenerative cell therapies.
[Bone Marrow Transplantation]
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The Emerging Role of Off-the-Shelf Engineered Natural Killer Cells in Targeted Cancer Immunotherapy

CAR-engineered natural killer (NK)-92 cells have demonstrated robust antitumor activity in in vitro and in vivo preclinical studies, propelling the clinical development of CAR NK-92 cells.
[Molecular Therapy-Oncolytics]
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Development of Injectable Graphene Oxide/Laponite/Gelatin Hydrogel Containing Wharton’s Jelly Mesenchymal Stem Cells for Treatment of Oxidative Stress-Damaged Cardiomyocytes

Injectable GO/laponite/gelatin (GO-LG) hydrogel was developed and characterized. The results of cell viability showed that the optimal concentration of GO flasks to treat cells was 100 μg/ml.
[Colloids and Surfaces B-Biointerfaces]
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Hepatocyte Organoids and Cell Transplantation: What the Future Holds

The authors describe strategies for establishing primary hepatocyte organoids derived from either adult or fetal liver based on insights from signaling pathways regulating hepatocyte renewal in vivo.
[Experimental & Molecular Medicine]
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Introducing Dorsoventral Patterning in Adult Regenerating Lizard Tails with Gene-Edited Embryonic Neural Stem Cells

Neural-stem cells were isolated from parthenogenetic lizard embryos, rendered unresponsive to Hedgehog signaling via CRISPR/Cas9 gene knockout of smoothened, and implanted back into clonally-identical adults to regulate tail regeneration.
[Nature Communications]
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