Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Subscribe|Follow Us On

Epigenetic Editing Balances TCR Suppression and Persistence in CAR T cells

March 5, 2026

[Molecular Therapy] Researchers presented an epigenetic editing approach that enables efficient, specific, and reversible silencing of the CD3ε gene, a critical component of the T cell receptor complex, without altering the genome.

Perfusion Microbioreactor for CAR-Treg Manufacturing

March 5, 2026

[iScience] Scientists developed the KCL-Microbioreactor, a closed microbioreactor platform based on microfluidic principles. They demonstrated the platform’s utility by generating functional CAR-Tregs targeting HLA-A2, achieving a 92% increase in yield compared to conventional methods.

A2 Biotherapeutics Doses First Patient in EVEREST-2 Study with A2B543, a Logic-Gated CAR T Cell Therapy Enhanced with a Membrane-Tethered IL-12 Booster

March 2, 2026

[A2 Biotherapeutics, Inc.] A2 Biotherapeutics, Inc. announced the first patient dosed with A2B543, an autologous CAR T cell therapy, initiating the second arm of the Phase I/II EVEREST-2 study.

TRIM13 In Situ Engineering Boosts Anti-Inflammatory Capacity of CAR-Ms for Liver Fibrosis Therapy

March 2, 2026

[Nature] Scientists reported tripartite motif containing 13 (TRIM13) engineered CAR-macrophages (CAR-Ms) for effectively manipulating the anti-inflammatory phenotype of CAR-Ms, augmenting their anti-fibrosis efficacy.

OR7A10 GPCR Engineering Boosts CAR-NK Therapy against Solid Tumours

March 2, 2026

[Nature] Engineering CAR-NK cells with OR7A10 cDNA enhanced their proliferation, activation, degranulation, cytokine production, death ligand expression, chemokine receptor expression, cytotoxicity, persistence, metabolic fitness and tumor microenvironment resistance.

MyD88-Mediated Chimaeric Antigen Receptor Macrophages Suppress Brain Metastasis Using Target-Specific Phagocytosis

March 2, 2026

[Nature Biomedical Engineering] Given the unique abilities of macrophages to cross the blood–brain barrier and exert their phagocytic function on tumour cells, researchers genetically engineered macrophages that express a CAR targeting mesothelin.

Antigen-Boosted CD4 CAR-T Cells Fail to Expand or Control Viremia in Multiple Nonhuman Primate Models of HIV

March 2, 2026

[Blood] Researchers tested a broad array of strategies to enhance CD4CAR-T cell efficacy, including CRISPR-Cas9-mediated gene editing of immune checkpoint and HIV-associated genes, single and pooled competitive infusions of engineered CAR-T cells, and exogenous antigen boosting.

Pluripotent Stem Cell-Derived CAR-NK Progenitor Therapy Targets Minimal Residual Disease and Prevents Relapse in Leukemia Models

March 2, 2026

[Cell Stem Cell] Scientists developed a PSC-derived induced natural killer lineage-committed progenitor cell therapy (iNKP) in leukemia models. They generated abundant iNKP cells via an organoid culture system.

KRASG12V/HLA-a*02:01-Targeted Chimeric Antigen Receptor T Cells Exhibit Potent Preclinical Activity against Solid Tumors

March 2, 2026

[Science Advances] Investigators developed CAR T cells targeting KRASG12V/HLA-A*02:01 using phage antibody display to identify high-affinity single-chain variable fragments.

Effective Allogeneic Natural Killer Cell Therapy for Pancreatic Adenocarcinoma Avails Conserved Activating Receptors and Evades HLA I-Driven Inhibition

March 2, 2026

[Journal for Immunotherapy of Cancer] In natural killer (NK)-competent humanized mice, adoptively transferred, unselected, unmodified NK cells slowed tumor growth in a dose-dependent manner, but NK cells selected to avoid HLA I-driven inhibition were the most competent effectors for PDAC control.

CAR T Cells and T Cell Engagers for Autoimmunity-Lessons from Hematology

February 23, 2026

[Bone Marrow Transplantation] The authors explore key insights gained from hematologic applications of CAR T cells and T cell engagers, and discuss how these lessons can guide the clinical use of these therapies in autoimmune diseases.

Cardiotoxicity of T Cell Immunotherapies

February 23, 2026

[Nature Reviews Cardiology] The authors summarize the mechanisms, epidemiology and management of T cell therapy-associated cytokine release syndrome and subsequent cardiotoxicity.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.