Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Human Umbilical Cord Mesenchymal Stem Cells for Psoriasis: A Phase I/IIa, Single-Arm Study

[Signal Transduction and Targeted Therapy] Investigators performed a Phase I/IIa, single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs in the treatment of psoriasis and preliminarily explored the possible mechanisms.

Preclinical Assessment of Antigen-Specific Chimeric Antigen Receptor Regulatory T Cells for Use in Solid Organ Transplantation

[Gene Therapy] Scientists reported the preclinical characterization of Tregs transduced with a human leukocyte antigen (HLA)-A*02 CAR lentiviral vector designated to induce immunosuppression of allograft-specific effector T cells in HLA-A*02-negative recipients of HLA-A*02-positive transplants.

Orca Bio Announces the Precision-T Phase III Study Is Open and Enrolling Patients at Transplant Centers across the US

[Orca Bio] Orca Bio announced Precision-T, its pivotal Phase III study, is open, enrolling and treating patients at clinical trial sites including Stanford Health Care, City of Hope, Winship Cancer Institute of Emory University, Sarah Cannon Research Institute, Ronald Reagan UCLA Medical Center and Oregon Health & Science University.

Exocrine Pancreas Regeneration Modifies Original Pancreas to Alleviate Diabetes in Mouse Models

[Science Translational Medicine] The authors showed that pancreas-derived mesenchymal stem cells were capable of regenerating exocrine pancreas when implanted into the kidney capsule of mice with streptozotocin–induced diabetes.

Genetically Engineered Viral Vectors and Organic-Based Non-Viral Nanocarriers for Drug Delivery Applications

[Advanced Healthcare Materials] The authors discuss research progress in developing various genetically engineered carriers. Organic-based nanoparticles including cellulose, collagen, silk-like polymers, elastin-like protein, silk-like elastane, and inorganic-based nanoparticles are discussed in detail.

Late to the CAR-T Game, AstraZeneca Quietly Works on Its Own Off-the-Shelf Therapies

[Fierce Biotech] While AstraZeneca may be a major player in the oncology space, the company has been noticeably absent as the first wave of CAR-T therapies hit the market over the past five years. But movement is happening behind the scenes.

UF Brain Cancer Researcher Awarded St. Baldrick’s Foundation Grant

[University of Florida Health] University of Florida (UF) brain cancer researcher Dr. Lan Hoang-Minh has been awarded a $100,000 grant from the St. Baldrick’s Foundation for a preclinical research project seeking to advance adoptive T cell therapy for pediatric brain tumors.

Intracavity Generation of Glioma Stem Cell–Specific CAR Macrophages Primes Locoregional Immunity for Postoperative Glioblastoma Therapy

[Science Translational Medicine] The authors reported a cavity-injectable nanoporter-hydrogel superstructure that created glioma stem cell-specific CAR macrophages/microglia surrounding the cavity to prevent glioblastoma multiforme relapse.

Poseida Therapeutics Announces Strategic Global Collaboration with Roche Focused on Allogeneic CAR-T Cell Therapies for Hematologic Malignancies

[Poseida Therapeutics, Inc.] Poseida Therapeutics, Inc. announced it has entered into a broad strategic collaboration and license agreement with Roche, focused on developing allogeneic CAR-T therapies directed to hematologic malignancies.

Spatiotemporal Control of Engineered Bacteria to Express Interferon-γ by Focused Ultrasound for Tumor Immunotherapy

[Nature Communications] Researchers showed that brief hyperthermia induced by focused ultrasound promoted the expression of IFN-γ gene, improving anti-tumor efficacy of ultrasound-responsive bacterium in vitro and in vivo.

Cardiomyocytes Induced from hiPSCs by Well-Defined Compounds Have Therapeutic Potential in Heart Failure by Secreting PDGF-BB

[Signal Transduction and Targeted Therapy] Investigators established a saponin+ compound optimally induced system to generate human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes with stable functional attributes in vitro and transplanted in heart failure mice.

A Humanized Knock-In Mouse Model of Duchenne Muscular Dystrophy and Its Correction by CRISPR-Cas9 Therapeutic Gene Editing

[Molecular Therapy-Nucleic Acids] Systemic CRISPR-Cas9 gene editing using an single guide RNAs (sgRNAs) that targeted human exon 51 efficiently restored dystrophin expression and ameliorated pathologic hallmarks of Duchenne muscular dystrophy, including histopathology and grip strength in a mouse model.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.