Constructing a Cell Microenvironment with Biomaterial Scaffolds for Stem Cell Therapy

In recent years, emerging biomaterials that provide a supportable cellular microenvironment for transplanted cells have optimized the therapeutic efficacy of stem cells in injured tissues or organs.
[Stem Cell Research & Therapy]
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CRISPR Therapeutics Announces FDA Regenerative Medicine Advanced Therapy (RMAT) Designation Granted to CTX110™ for the Treatment of Relapsed or Refractory CD19+ B Cell Malignancies

CRISPR Therapeutics announced that the FDA granted Regenerative Medicine Advanced Therapy designation to CTX110™, its wholly-owned allogeneic CAR-T cell therapy targeting CD19+ B-cell malignancies.
[CRISPR Therapeutics]
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CRISPR-Enhanced Human Adipocyte Browning as Cell Therapy for Metabolic Disease

Scientists applied methods to greatly expand human adipocyte progenitors from small samples of human subcutaneous adipose tissue and then disrupt the thermogenic suppressor gene NRIP1 by CRISPR.
[Nature Communications]
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Simultaneous Silencing of A2aR and PD-1 as Immune Checkpoints by siRNA-Loaded Nanoparticles Enhances the Immunotherapeutic Potential of Dendritic Cell Vaccine in Tumor Experimental Models

Scientists inhibited two of the most important immune checkpoints expressed on T cells infiltrated in tumors, including PD-1 and A2aR. Ligation of PD-1 with PD-L1 and A2aR with adenosine significantly suppress T cell responses against tumor cells.
[Life Sciences]
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Targeting p21Cip1 Highly Expressing Cells in Adipose Tissue Alleviates Insulin Resistance in Obesity

Using single-cell transcriptomics, the authors identified a small, critically important, but previously unexamined cell population, p21Cip1 highly expressing (p21high) cells, which accumulated in adipose tissue with obesity.
[Cell Metabolism]
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Sulforaphane Enhances the Antitumor Response of Chimeric Antigen Receptor T Cells by Regulating PD-1/PD-L1 Pathway

The effect of combined SFN and CAR-T cells was determined in vitro using a co-culture system and in vivo using a xenograft mouse model. They furthered validated the effects of combination therapy in patients with cancer.
[BMC Medicine]
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Comparing Cord Blood Transplantation and Matched Related Donor Transplantation in Non-Remission Acute Myeloid Leukemia

Scientists investigated the impact of cord blood transplantation, compared to human leukocyte antigen-matched related donor transplantation.
[Leukemia]
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Impact of Donor Types on Reduced-Intensity Conditioning Allogeneic Stem Cell Transplant for Mature Lymphoid Malignancies

Scientists retrospectively compared the outcomes of reduced-intensity conditioning transplantation from matched related donors matched unrelated donors, and umbilical cord blood for mature lymphoid malignancies.
[Bone Marrow Transplantation]
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Neoantigen-Reactive CD8+ T Cells Affect Clinical Outcome of Adoptive Transfer with Tumor-Infiltrating Lymphocytes in Melanoma

Using barcoded pMHC multimers, scientists provided a comprehensive mapping of CD8+ T cells recognizing neoepitopes in Tumor-Infiltrating Lymphocyte infusion products and blood samples from 26 metastatic mela-noma patients who received adoptive cell therapy.
[Journal of Clinical Investigation]
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Lin Ma Named 2021 STEM CELLS Young Investigator

Dr. Lin Ma is the recipient of STEM CELLS’s Young Investigator Award for 2021. Her work on engineering hypoimmunogenic human PSCs exemplifies the potential of the field and promise of this young next generation of researchers.
[ALPHAMED PRESS (EurekAlert!)]
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Cytovia and Cellectis Expand Their TALEN® Gene-Edited iNK Partnership to Enable Broader Collaboration in China

Cytovia Therapeutics, Inc. and Cellectis announced that they have expanded their collaboration of TALEN® gene-edited iPSC-derived natural killer (NK) and chimeric antigen receptor (CAR)-NK cells to include new CAR target and development in China by Cytovia’s joint venture entity, CytoLynx Therapeutics.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]
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