QDPR Deficiency Drives Immune Suppression in Pancreatic Cancer

Scientists demonstrated that the deficiency of quinoid dihydropteridine reductase (QDPR), a critical enzyme regulating biopterin metabolism, caused metabolite dihydrobiopterin (BH2) accumulation and decrease the ratio of tetrahydrobiopterin to BH2 in pancreatic ductal adenocarcinomas.