Noshin Noorjahan

[Cancer Discovery] The authors showed that the LINE-1 ORF1 protein (ORF1p) in PDAC cells played a role in shielding repeat RNAs from activating a pathogen recognition receptor-mediated antiviral response that is independent of retrotransposition.

[Cell Death & Disease] The authors reported that TRIM8 could act as a tumor suppressor in NSCLC. Both gain- and loss-of-function experiments revealed that TRIM8 inhibited the proliferation, colony formation, migration, and invasion of NSCLC cells.

[Advanced Science] Researchers reported that POU-domain containing family protein POU3F3 was translocated into the nuclei of NSCLC cell lines harboring mutant RAS, where it activated transcription of ATP5PF leading to enhanced NSCLC proliferation and migration.

[Nature] Scientists showed that neuroendocrine (NE) cells, but not non-NE cells, were excitable, and their action potential firing directly promoted SCLC malignancy.

[Autophagy] Scientists explored the role of the small molecular chaperone HSPB1 in counteracting neurodegeneration induced by poly-glycine aggregates.

[Journal of Clinical Investigation] The authors reported that loss of tumor necrosis factor receptor-associated factor 3 (TRAF3) in glioblastoma critically regulated lipid peroxidation and tumorigenesis by controlling the oxidation of polyunsaturated fatty acids.