Noshin Noorjahan

Cancer Stem Cell News

KIF20A Inhibits TRIM21-Dependent Ubiquitination of DHX9 to Boost SOX2 Stability, Enhancing OSCC Stemness, and Ferroptosis Resistance

[Cell Death & Disease] Mechanistic investigations revealed that KIF20A regulates DHX9 nucleocytoplasmic distribution and inhibits TRIM21-mediated K48-linked polyubiquitination at DHX9-K755, thereby preventing its proteasomal degradation and enhancing protein stability.

Cancer Stem Cell News

KDM6A Alternative Splicing Induced by 25(OH)D Inhibits Breast Cancer Cell Stemness through Repressing TRAP1 Transcription

[Oncogene] Investigators revealed for the first time that 25-Hydroxyvitamin D (25(OH)D) exerts antitumor effects by promoting exon 13 skipping of KDM6A, which suppresses the proliferation and stemness of breast cancer cells and lacks H3K27 demethylase activity.

Cancer Stem Cell News

KCTD15 Enhances Stem Cell-Like Properties and Promotes Triple-Negative Breast Cancer Progression through KLF4/β-Catenin Signaling

[FASEB Journal] Scientists elucidated the functional role of the potassium channel tetramerization domain 15 (KCTD15) in triple-negative breast cancer progression, providing mechanistic insights into its potential as a therapeutic target for this challenging disease.

Cancer Stem Cell News

Synthetic Lethality and DNA Damage Response Targeting in Cancer Stem Cells: A Comprehensive Review

[Discover Oncology] The authors synthesize current preclinical and clinical advancements in targeting CSCs via DNA damage response inhibitors, including PARP, ATR, ATM, and DNA-PKcs inhibitors, as well as emerging synthetic lethality targets.

Cancer Stem Cell News

US FDA Approves Novocure’s Optune Pax® for the Treatment of Locally Advanced Pancreatic Cancer

[Novocure] Novocure announced that the US FDA approved Optune Pax^® for the treatment of adult patients with locally advanced pancreatic cancer concomitant with gemcitabine and nab-paclitaxel.

Extracellular Matrix News

Sensory Neurons Drive Immune Exclusion by Stimulating a Dense Extracellular Matrix in the Breast Cancer Tumor Microenvironment

[Cell] The authors deciphered that sensory neurons, the dominant neuron type in the triple negative breast cancer ecosystem, drive the immune-excluded tumor microenvironment by stimulating a dense extracellular matrix.

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Gli2 and Gli3 Synergistically Mediate HH-TGF-β Crosstalk in Mesenchymal Progenitor Cells to Orchestrate Tooth Root Morphogenesis

[International Journal of Oral Science] Scientists revealed that loss of Gli3 alone in dental mesenchymal root progenitor cells caused shortened roots and that concurrent loss of Gli2 and Gli3 exacerbated root malformations, concomitant with profound impairments in cell proliferation and multilineage differentiation.

Microfluidic Encapsulation of Genetically Engineered Bone-Marrow-Derived Mesenchymal Stem Cells for Bone Defect Healing

[Advanced Healthcare Materials] Researchers transfected bone MSCs with RUNX2 plasmid nanoparticles and encapsulated them into gelatin methacryloyl hydrogel microcarriers for bone regeneration.

SLIT3/ROBO1 Axis Contributes to Angiogenic-Osteogenic Coupling in Endothelial Progenitor Cells and Peripheral Blood Mesenchymal Stem Cells

[Stem Cell Research & Therapy] Investigators constructed endothelial progenitor cells/peripheral blood derived-MSCs sheets and evaluated their repair value and potential molecular mechanisms in bone regeneration.

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Noshin Noorjahan

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