Noshin Noorjahan

Hepatic Cell News

YTHDF1 Mediates KLF2/VSIG4 Axis to Regulate Kupffer Cell Polarization to Alleviate Sepsis-Induced Liver Injury

[Genes & Immunity] The effect of YTH domain N6-methyladenosine RNA binding protein F1 (YTHDF1) on Kupffer cell polarization in sepsis was evaluated.

Hepatic Cell News

METTL5 Promotes Fatty Acid Metabolism by Modulating Peroxisome to Promote Hepatocellular Carcinoma Recurrence after Thermal Ablation

[Molecular Therapy] Researchers found that the levels of methyltransferase 5 (METTL5) and 18S rRNA m⁶A modification were significantly upregulated in post-radiofrequency ablation (RFA) recurrent HCC and were further verified by insufficient RFA models in vitro and in vivo.

Hepatic Cell News

Targeting MORF4L1-Mediated DNA Repair Potentiates RT-Induced Antitumor Immunity via cGAS-STING Activation in Hepatocellular Carcinoma

[Cellular & Molecular Immunology] Single-cell and bulk RNA sequencing analyses identified the DNA damage repair gene mortality factor 4-like 1 (MORF4L1) as a critical regulator of hepatocellular carcinoma progression and resistance to radiotherapy.

Hepatic Cell News

Diclofenac and Acetaminophen Dim the Acute-Phase Response but Amplify Expression of the Iron Regulator Hepcidin in Liver Cancer Cells

[Cell Systems] Using proteomics and dynamic pathway modeling, investigators showed that diclofenac and acetaminophen directly impact IL-6 signaling by enhancing the induction of the feedback-inhibitor suppressor of cytokine signaling 3.

Hepatic Cell News

Hypoxia-Mediated m6a Modulation in Hepatocellular Carcinoma: A Comprehensive Review

[Journal of Translational Medicine] Investigators systematically elucidate the molecular mechanisms by which hypoxia-inducible factor and key m6A-modifying enzymes jointly regulate HCC progression within the hypoxic microenvironment.

Hepatic Cell News

Mursla Bio Collaborates with a Leading Global Pharma Company to Advance Biomarker-Guided Precision Medicine in MASH

[Mursla Bio] Mursla Bio announced a collaboration with a leading global pharmaceutical company recognized for its expertise in precision medicine and biomarker-guided drug development.

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Unmasking Cancer’s Silent Saboteurs: T Regulatory Cells As Therapeutic Targets in Immunotherapy

[Expert Review of Clinical Immunology] Scientists explore the role of Tregs in the immune system, delve into their contribution to cancer and tumor progression, and highlight therapeutic strategies targeting Tregs, along with innovative delivery systems.

Destruction of VISTA by TRIM25 Ablation in T Cells Potentiates Cancer Immunotherapy

[Cell Research] Researchers unveiled a mechanism for V-domain Ig suppressor of T cell activation (VISTA) regulation in T cells and highlights targeting tripartite motif containing 25 (TRIM25)–VISTA as a potential strategy to enhance tumor immunotherapy.

The IL-1R and NFKBIZ Pathway Mediates Immunoregulatory Responses and Immunotherapy Efficacy in Anaplastic Large Cell Lymphoma

[Leukemia] The authors conducted integrated genome-wide CRISPR-Cas9 loss-of-function screens using CD30-specific CAR-engineered NK cells, alongside a complementary PD-L1 regulator screen, and uncovered a critical role for interleukin-1 receptor signaling in modulating CAR therapy efficacy in both ALK^⁺ and ALK^⁻ anaplastic large cell lymphoma.

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Noshin Noorjahan

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