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Noshin Noorjahan

Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond

[Hypertension] The authors summarize the latest understanding of the molecular mechanisms by which smooth muscle cell-mineralocorticoid receptor contributes to regulation of vasomotor function and blood pressure , and more.

Pathogenic GATA2 Genetic Variants Utilize an Obligate Enhancer Mechanism to Distort a Multilineage Differentiation Program

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists used a GATA2-deficient progenitor rescue system to analyze how genetic variation influences GATA2 functions.

KCTD5 Regulates Ikaros Degradation Induced by Chemotherapeutic Drug Etoposide in Hematological Cells

[Biological Chemistry] Researchers showed that chemotherapeutic drug etoposide reduced the protein levels of several isoforms of Ikaros including IK1, IK2 and IK4, but not IK6 or IK7, by accelerating protein degradation, in leukemic cells.

Neuronal Dynamics Direct Cerebrospinal Fluid Perfusion and Brain Clearance

[Nature] The authors demonstrated that neural networks synchronized individual action potentials to create large-amplitude, rhythmic, and self-perpetuating ionic waves in the interstitial fluid of the brain.

Neural Conditional Ablation of the Protein Tyrosine Phosphatase Receptor Delta PTPRD Impairs Gliogenesis in the Developing Mouse Brain Cortex

[Frontiers in Cell and Developmental Biology] The authors developed a conditional knockout mouse model lacking phosphatase receptor delta (PTPRD) expression in telencephalon cells. They found that the lack of PTPRD in the mouse cortex reduces glial precursors, astrocytes, and oligodendrocytes.

E-Cadherin Loss Drives Diffuse-Type Gastric Tumorigenesis via EZH2-Mediated Reprogramming

[Journal Of Experimental Medicine] Researchers discovered CDH1 inactivation in a subset of diffuse-type gastric adenocarcinoma (DGAC) patient tumors. Analyzing single-cell transcriptomes in malignant ascites, they identified two DGAC subtypes: DGAC1 (CDH1 loss) and DGAC2 (lacking immune response).

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Endocrinology of the Aging Prostate: Current Concepts

[Frontiers In Endocrinology] Scientists systematically review the impact of hormonal changes that occur during aging on the prostate, including the role of sex hormones, insulin-like growth factor 1, thyroid hormones, and insulin.

Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway

[Research] Gradient rotating magnetic field exposure had a notable impact on the F-actin arrangement of MDA-MB-231, BT-549, and MDA-MB-468 cells, inhibiting cell migration and invasion.

LINC00460-FUS-MYC Feedback Loop Drives Breast Cancer Metastasis and Doxorubicin Resistance

[Oncogene] LINC00460 was demonstrated to promote stem cell-like and epithelial-mesenchymal transition characteristics in breast cancer cells.