Noshin Noorjahan

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The Gut Microbiome-Prostate Cancer Crosstalk Is Modulated by Dietary Polyunsaturated Long-Chain Fatty Acids

[Nature Communications] Scientists showed a reduction in fecal microbiota alpha-diversity correlating with increase tumor burden in two distinct groups of hormonotherapy naïve prostate cancer (PCa) patients and three murine PCa models.

Muscle Cell News

LSD1 Inhibition Circumvents Glucocorticoid-Induced Muscle Wasting of Male Mice

[Nature Communications] Researchers showed that glucocorticoid receptor (GR) and the lysine-specific demethylase 1 (LSD1) interact in myofibers of male mice, and that LSD1 connected GR-bound enhancers with NRF1-associated promoters to stimulate target gene expression.

Hematopoiesis News

Mis-Expression of GATA6 Re-programs Cell Fate during Early Hematopoiesis

[Cell Reports] In Max41 transgenic mice, nearly all B cells diverted into the granulocyte lineage. Investigators showed that these mice had an excess of myeloid progenitors, but their common lymphoid progenitor compartment was ablated, and they had few plasmacytoid dendritic cells.

Hematopoiesis News

Not Just for Lymphoid Cells: The Role of the Noncanonical NF-κB Signaling Pathway in Early and Late Myelopoiesis with a Focus on Hypereosinophilic Disorders

[Journal of Leukocyte Biology] The authors discuss the molecular machinery within the noncanonical NF-κB pathway, crosstalk with the canonical NF-κB pathway, murine models of noncanonical signaling, as well as how aberrations in this pathway manifest in leukemic or hyperinflammatory disease with a focus on Hypereosinophilic syndrome.

Hematopoiesis News

$2.7 Million Grant to Explore Hypoxia’s Impact on Blood Stem Cells

[Indiana University School of Medicine (EurekAlert)] A new four-year, $2.7 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases will support the project, “Hypoxia's role in regulating stressed hematopoietic stem cells,” led byIndiana University School of Medicine scientists.

Mesenchymal Cell News

HOXB5 Promotes the Progression and Metastasis of Osteosarcoma Cells by Activating the JAK2/STAT3 Signaling Pathway

[Heliyon] The expression of homeobox gene B5 (HOXB5) in human osteosarcoma tissues and its correlation with clinical indicators were investigated using bioinformatics analysis and immunohistochemical labelling.

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Sylvester Cancer Adding Cellular Therapy to its Arsenal against Metastatic Melanoma

[University of Miami Miller School of Medicine (EurekAlert!)] Patients in South Florida with metastatic melanoma will soon have access to tumor-infiltrating lymphocyte therapy, following its recent approval by the FDA. It will be available to patients at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.

The Role of Yes Activated Protein (YAP) in Melanoma Metastasis

[iScience] The authors discuss how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.

Exploration of the Photothermal Role of Curcumin-Loaded Targeted Carbon Nanotubes as a Potential Therapy for Melanoma Cancer

[Scientific Reports] Scientists designed and evaluated targeted carbon nanotubes containing curcumin, and assessed their in vitro cytotoxicity effects on melanoma cancer cells.

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Noshin Noorjahan

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