Noshin Noorjahan

Extracellular Matrix News

Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis

[Advanced Materials] Scientists hypothesized that ECM softening in periodontal disease contributes to inflammation by dysregulating gingival fibroblasts.

Cancer Stem Cell News

Extracellular Matrix Mediates Circulating Tumor Cell Clustering in Triple-Negative Breast Cancer Metastasis

[Nature Communications] Researchers showed that the ECM component hyaluronan mediates adherens junction-independent circulating tumor cell clustering in triple-negative breast cancers.

Extracellular Matrix News

FOXI3 Establishes the Ectodermal Niche in Pharyngeal Arches for Cranial Neural Crest Cells and Their Lineages

[Bone Research] Deletion of Foxi3 in the mouse cranial neural crest cells (CNCCs) did not disrupt mandible and auricular development, further confirming that FOXI3 does not directly regulate CNCCs.

Extracellular Matrix News

A TRPV4-Dependent Calcium Signaling Axis Regulates Lamellipodial Actin Architecture to Promote Cell Migration

[Current Biology] Investigators identified a novel calcium signaling axis involving the mechano-gated channel transient receptor potential vanilloid 4 (TRPV4), which regulates lamellipodial protrusions in various cell types.

Extracellular Matrix News

Matrix Stiffness-Induced NARF Promotes Hepatocellular Carcinoma Progression by Enhancing LEF1-Mediated Transcription

[Biochimica Et Biophysica Acta-Molecular Cell Research] Scientists identified nuclear prelamin A recognition factor (NARF) as a novel matrix stiffness-responsive gene, whose transcription is directly regulated by the mechanosensor Yes-associated protein.

Extracellular Matrix News

Esculin Improves Wound Healing in Diabetic Rats by Modulating Extracellular Matrix Remodeling and Molecular Pathways

[Scientific Reports] The authors investigated the histopathological, biochemical, and molecular effects of topical esculin on full-thickness wounds in streptozotocin-induced diabetic rats.

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Challenges and Opportunities in Combining Radiotherapy and Immunotherapy for Localized Pancreatic Cancer

[Nature Reviews Gastroenterology & Hepatology] Expanding preclinical and clinical literature from PDAC and other oncological indications identifies novel approaches through which radiation therapy–immunotherapy combinations could improve local and systemic disease control in patients with PDAC.

Developmental and MAPK-Responsive Transcription Factors Regulate Distinct Malignant Cell States and Associated Genetic Dependencies in Pancreatic Cancer

[Nature Genetics] Single-cell master regulator analysis of multiple pancreatic ductal adenocarcinoma cohorts identified malignant cells in three co-existing, molecularly distinct developmental lineage states, with distinct histopathological morphologies and spatial architecture.

FDA Approves First in Class Targeted Therapy for Metastatic Pancreatic Cancer

[US FDA] The US FDA approved Rasonque (daraxonrasib), a RAS inhibitor for the most common form of pancreatic cancer—delivering a new treatment option to patients with advanced pancreatic cancer months ahead of schedule.

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Noshin Noorjahan

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