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Noshin Noorjahan

HOIL-1L Deficiency Induces Cell Cycle Alteration Which Causes Immaturity of Skeletal Muscle and Cardiomyocytes

[Scientific Reports] The authors elucidated the mechanisms by which myopathy and dilated cardiomyopathy develop using the murine myoblast cell line C2C12 and disease-specific human induced pluripotent stem cells.

Brain Endothelial GSDMD Activation Mediates Inflammatory BBB Breakdown

[Nature] Scientists found that activation of the pore-forming protein GSDMD by the cytosolic lipopolysaccharide (LPS) sensor caspase-11, but not by TLR4-induced cytokines, mediated BBB breakdown in response to circulating LPS or during LPS-induced sepsis.

Inhibition of the Galactosyltransferase C1GALT1 Reduces Osteosarcoma Cell Proliferation by Interfering with Erk Signaling and Cell Cycle Progression

[Cancer Gene Therapy] Researchers screened for differentially expressed genes in osteosarcoma. They found that osteosarcoma cases could be divided into fair and poor survival groups based on gene expression profiles.

Caspase 8 Deletion Causes Infection/Inflammation-Induced Bone Marrow Failure and MDS-Like Disease in Mice

[Cell Death & Disease] Caspase 8 (Casp8) is a master regulator of pyroptosis, apoptosis, and necroptosis (PANoptosis). To study the role of PANoptosis in hematopoiesis, scientists generated inducible Casp8 knockout mice.

Mannose Controls Mesoderm Specification and Symmetry Breaking in Mouse Gastruloids

[Developmental Cell] To understand how metabolism impacted early mesoderm development, scientists used mESC-derived gastruloids, that co-expressed glucose transporters with the mesodermal marker T/Bra.

Inflammatory and Tissue Injury Marker Dynamics in Pediatric Acute Respiratory Distress Syndrome

[Journal Of Clinical Investigation] In a single-center prospective cohort of intubated pediatric acute respiratory distress syndrome, investigators collected plasma on days zero, three, and seven. Nineteen biomarkers reflecting inflammation, tissue injury, and damage associated molecular patterns were measured.

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Arginine Ingestion Inhibits Phagocyte Invasion in Eccentrically Contracted Rat Fast-Twitch Muscle

[Journal of Muscle Research and Cell Motility] Scientists investigated whether prior ingestion of L-arginine, a nitric oxide precursor, inhibited eccentric contraction-induced macrophage invasion.

KLF13 Promotes VSMCs Phenotypic Dedifferentiation by Directly Binding to the SM22α Promoter

[Journal of Cellular Physiology] The authors investigated the relationship between KLF13 and SM22α expression in normal and atherosclerotic plaques by bioanalysis, and observed a significant increase in KLF13 levels in the atherosclerotic plaques of both human patients and ApoE−/− mice.

Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension

[Circulation Research] Researchers studied cyclophilin D (CypD) acetylation in patients with essential hypertension, defined a pathogenic role of CypD acetylation in deacetylation mimetic CypD-K166R mutant mice and endothelial-specific general control of amino acid synthesis 5 like 1–deficient mice using an angiotensin II model of hypertension.