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Noshin Noorjahan

HDL-Bound S1P Affects the Subventricular Niche and Early Neuropathological Features of Alzheimer’s Disease

[Nature Communications] Using apolipoprotein M (Apom)-/- mice, scientists showed that blood ApoM-sphingosine-1-phosphate (S1P) deficiency impairs the subventricular zone-NSC pool, neurogenesis, ependymal cell polarity, and cerebrospinal fluid flow.

Connexin43 Hemichannel Blockade Turns Microglia Neuroprotective and Mitigates Cognitive Deficits in a Mouse Model of Amyloidosis

[Nature Communications] Researchers identified microglial connexin43 hemichannels as a regulator of microglial reactivity in Alzheimer's disease, positioning them as a promising therapeutic target.

Rutin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions by Inhibiting Oxidative Stress Injury and the Inflammatory Response in Mice via the Keap1/Nrf2 Signaling Pathway

[Scientific Reports] To investigate the protective effects of rutin in imiquimod (IMQ)-induced psoriasis model mice and its underlying molecular mechanism, IMQ was applied to mice to induce inflammatory skin that phenotypically mimics psoriasis.

Direct Lineage Reprogramming of Fibroblasts into Functional Keratinocyte-Like Cells via BMI1 and FGFR2b for Diabetic Wound Repair

[Stem Cell Reviews and Reports] Researchers established a novel reprogramming approach using a combination of two factors, BMI1 and FGFR2b, to induce fibroblast-to-keratinocyte-like cells conversion in vitro and delivered via adeno-associated virus 9 in vivo.

Oxyresveratrol Suppressed Melanogenesis, Dendrite Formation, and Melanosome Transport in Melanocytes via Regulation of the MC1R/cAMP/MITF Pathway

[Scientific Reports] The effects and mechanisms of oxyresveratrol on melanogenesis, dendrite formation, and melanosome transport were investigated.

CFAP100 Couples Microtubule Glutamylation to Spindle Pole Integrity in Keratinocytes to Promote Epidermal Development

[Nature Communications] Researchers demonstrated an essential role for cilia and flagella associated protein 100 (CFAP100) in keratinocyte division.

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Pancreatic β-cell Regeneration In Situ by the ALK3 Agonist THR-123

Scientists tested the ability of THR-123, a cyclic peptide with BMP-7-like activity, to regenerate β-cell mass in diabetic mice. [Nature Communications] Full Article

Pancreatic Islet β-cell Subtypes are Derived from Biochemically-Distinct and Nutritionally-Regulated Islet Progenitors

Researchers showed that islet progenitors with distinct gene expression and DNA methylation patterns produced β-cell subtypes of different secretory function, proliferation rate, and viability in male and female mice. [Nature...

Non-Canonical ALK7 Pathways Promote Pancreatic Cancer Metastasis Through β-Catenin/MMP-Mediated Basement Membrane Breakdown and Intravasation

[Molecular Cancer] Researchers identify two distinct but interconnected activin receptor-like kinase 7 (ALK7)-driven non-canonical pathways that promote PDAC dissemination.