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Noshin Noorjahan
Neural Cell News
HDL-Bound S1P Affects the Subventricular Niche and Early Neuropathological Features of Alzheimer’s Disease
[Nature Communications] Using apolipoprotein M (Apom)-/- mice, scientists showed that blood ApoM-sphingosine-1-phosphate (S1P) deficiency impairs the subventricular zone-NSC pool, neurogenesis, ependymal cell polarity, and cerebrospinal fluid flow.
Neural Cell News
Connexin43 Hemichannel Blockade Turns Microglia Neuroprotective and Mitigates Cognitive Deficits in a Mouse Model of Amyloidosis
[Nature Communications] Researchers identified microglial connexin43 hemichannels as a regulator of microglial reactivity in Alzheimer's disease, positioning them as a promising therapeutic target.
Dermal Cell News
Rutin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions by Inhibiting Oxidative Stress Injury and the Inflammatory Response in Mice via the Keap1/Nrf2 Signaling Pathway
[Scientific Reports] To investigate the protective effects of rutin in imiquimod (IMQ)-induced psoriasis model mice and its underlying molecular mechanism, IMQ was applied to mice to induce inflammatory skin that phenotypically mimics psoriasis.
Dermal Cell News
Direct Lineage Reprogramming of Fibroblasts into Functional Keratinocyte-Like Cells via BMI1 and FGFR2b for Diabetic Wound Repair
[Stem Cell Reviews and Reports] Researchers established a novel reprogramming approach using a combination of two factors, BMI1 and FGFR2b, to induce fibroblast-to-keratinocyte-like cells conversion in vitro and delivered via adeno-associated virus 9 in vivo.
Dermal Cell News
Oxyresveratrol Suppressed Melanogenesis, Dendrite Formation, and Melanosome Transport in Melanocytes via Regulation of the MC1R/cAMP/MITF Pathway
[Scientific Reports] The effects and mechanisms of oxyresveratrol on melanogenesis, dendrite formation, and melanosome transport were investigated.
Dermal Cell News
CFAP100 Couples Microtubule Glutamylation to Spindle Pole Integrity in Keratinocytes to Promote Epidermal Development
[Nature Communications] Researchers demonstrated an essential role for cilia and flagella associated protein 100 (CFAP100) in keratinocyte division.
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Pancreatic β-cell Regeneration In Situ by the ALK3 Agonist THR-123
Scientists tested the ability of THR-123, a cyclic peptide with BMP-7-like activity, to regenerate β-cell mass in diabetic mice.
[Nature Communications] Full Article
Pancreatic Islet β-cell Subtypes are Derived from Biochemically-Distinct and Nutritionally-Regulated Islet Progenitors
Researchers showed that islet progenitors with distinct gene expression and DNA methylation patterns produced β-cell subtypes of different secretory function, proliferation rate, and viability in male and female mice.
[Nature...
Non-Canonical ALK7 Pathways Promote Pancreatic Cancer Metastasis Through β-Catenin/MMP-Mediated Basement Membrane Breakdown and Intravasation
[Molecular Cancer] Researchers identify two distinct but interconnected activin receptor-like kinase 7 (ALK7)-driven non-canonical pathways that promote PDAC dissemination.