Noshin Noorjahan

[Developmental Cell] Investigators elucidated the pivotal role of Frizzled5 (Fzd5), a Wnt pathway receptor, as a determinant of murine intestinal epithelial cell fate.

[Developmental Cell] An epithelial-specific Fzd5 knockout (KO) elicited lethal pan-intestinal crypt and villus loss, whereas an Lgr5+ intestinal stem cell (ISC)-specific Fzd5 KO depleted Lgr5+ ISCs via premature differentiation and repressed Wnt target genes.

[Cellular & Molecular Biology Letters] Protocadherin gamma subfamily A, 9 (PCDHGA9) expression was detected using quantitative real-time quantitative polymerase chain reaction in 63 pairs of colorectal cancer tissues.

[Journal of Translational Medicine] Scientists identified new targets for predicting and treating colorectal cancer (CRC) liver metastasis (CRLM). Bioinformatics analysis highlighted the miR-122/NEGR1 axis as crucial in CRLM. In vitro assays explored the impact of this axis on CRC cell proliferation, invasion, and migration.

[BMC Cancer] In Ardabil, a high-risk area in North‒West Iran, 795 blood samples were collected from 396 cases and 399 controls.

[Aging Cell] Researchers utilized an aging Drosophila model screening of amino acids and found that asparagine, a nonessential amino acid in vivo, exhibited its profound anti-aging properties on intestinal stem cells.