Noshin Noorjahan

Extracellular Matrix News

Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis

[Advanced Materials] Scientists hypothesized that ECM softening in periodontal disease contributes to inflammation by dysregulating gingival fibroblasts.

Cancer Stem Cell News

Extracellular Matrix Mediates Circulating Tumor Cell Clustering in Triple-Negative Breast Cancer Metastasis

[Nature Communications] Researchers showed that the ECM component hyaluronan mediates adherens junction-independent circulating tumor cell clustering in triple-negative breast cancers.

Extracellular Matrix News

FOXI3 Establishes the Ectodermal Niche in Pharyngeal Arches for Cranial Neural Crest Cells and Their Lineages

[Bone Research] Deletion of Foxi3 in the mouse cranial neural crest cells (CNCCs) did not disrupt mandible and auricular development, further confirming that FOXI3 does not directly regulate CNCCs.

Extracellular Matrix News

A TRPV4-Dependent Calcium Signaling Axis Regulates Lamellipodial Actin Architecture to Promote Cell Migration

[Current Biology] Investigators identified a novel calcium signaling axis involving the mechano-gated channel transient receptor potential vanilloid 4 (TRPV4), which regulates lamellipodial protrusions in various cell types.

Extracellular Matrix News

Matrix Stiffness-Induced NARF Promotes Hepatocellular Carcinoma Progression by Enhancing LEF1-Mediated Transcription

[Biochimica Et Biophysica Acta-Molecular Cell Research] Scientists identified nuclear prelamin A recognition factor (NARF) as a novel matrix stiffness-responsive gene, whose transcription is directly regulated by the mechanosensor Yes-associated protein.

Extracellular Matrix News

Esculin Improves Wound Healing in Diabetic Rats by Modulating Extracellular Matrix Remodeling and Molecular Pathways

[Scientific Reports] The authors investigated the histopathological, biochemical, and molecular effects of topical esculin on full-thickness wounds in streptozotocin-induced diabetic rats.

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Maternal Influences on Infant Gut Microbiome and Health

[Nature] Researchers metagenomically sequenced 4,526 longitudinal fecal samples from 714 mother–infant pairs. They observed that the maternal gut microbiome undergoes only subtle changes during pregnancy and postpartum, influenced by diet, infections, and pre-pregnancy smoking.

In Vivo Genome-Wide CRISPR Screens of Human T Cells in Solid Tumours

[Nature] Scientists developed an in vivo model that efficiently recovers human T cells from solid tumours, permitting genome-wide CRISPR screens with few mice. Tumor-infiltrating T cells from this model exhibit hallmarks of dysfunction compared with splenic T cells, creating an ideal screening context.

PRMT5-Mediated Intron Retention Triggers Innate and Adaptive Immunity against Cancer

[EMBO Molecular Medicine] Scientists defined a new role for PRMT5 in regulating and coordinating the interplay between the innate and adaptive immune response.

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Noshin Noorjahan

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