Noshin Noorjahan

Mammary Cell News

Phase Separation of Phospho-HDAC6 Drives Aberrant Chromatin Architecture in Triple-Negative Breast Cancer

[Nature Cancer] Scientists demonstrated that phosphorylated histone deacetylase 6 (phospho-HDAC6) formed liquid–liquid phase separation condensates in the nuclei of TNBC cells that were essential for establishing aberrant chromatin architecture.

Human Immunology News

Sintilimab in Combination with Stereotactic Body Radiotherapy and Granulocyte-Macrophage Colony-Stimulating Factor in Metastatic Non-small Cell Lung Cancer: The Multicenter SWORD Phase II Trial

[Nature Communications] This single-arm, multicenter, Phase II trial investigated the triple combination of sintilimab, stereotactic body radiotherapy and granulocyte-macrophage colony-stimulating factor in metastatic non-small cell lung cancer.

Endothelial Cell News

AQP1 Differentially Orchestrates Endothelial Cell Senescence

[Redox Biology] The authors delineated a previously unrecognized role of aquaporin 1 (AQP1) in orchestrating extracellular hydrogen peroxide-induced cellular senescence in aortic endothelial cells.

Immunology of Infectious Disease News

NIH Grant Establishes UAB’s Global Research Resource for Human Tuberculosis

[University of Alabama at Birmingham] A $5.8 million grant led by Adrie Steyn, Ph.D., of the University of Alabama at Birmingham and the Africa Health Research Institute, will provide user-requested infected human lung tissue and analytical services to tuberculosis researchers worldwide.

Immunology of Infectious Disease News

Robust SARS-CoV-2-Neutralizing Antibodies Sustained through Six Months Post XBB.1.5 mRNA Vaccine Booster

[Cell Reports Medicine] The authors performed neutralization assays on four viral variants, D614G, BA.5, XBB.1.5, and JN.1, using sera from participants obtained at ∼one month, ∼three months, and ∼six months post an XBB.1.5 monovalent mRNA vaccine booster.

Immunology of Infectious Disease News

Conservation of Antiviral Systems across Domains of Life Reveals Immune Genes in Humans

[Cell Host & Microbe] The authors used a phylogeny-driven approach to uncover eukaryotic immune proteins by searching for homologs of bacterial antiphage systems.

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Diterpenoid DGT Alleviates Atopic Dermatitis–Like Responses In Vitro and In Vivo via Targeting IL-4Rα

[Biomedicine & Pharmacotherapy] Researchers observed anti-inflammatory effects of DGT on tumor necrosis factor-α/interferon-γ–treated human keratinocytes, and anti-allergic effects on immunoglobulin E–sensitized bone marrow–derived mast cells.

An Isoform-Resolution Transcriptomic Atlas of Colorectal Cancer from Long-Read Single-Cell Sequencing

[Cell Genomics] Investigators integrated short- and long-read scRNA-seq of colorectal cancer (CRC) samples to build an isoform-resolution CRC transcriptomic atlas. They identified 394 dysregulated transcript structures in tumor epithelial cells, including 299 resulting from various combinations of splicing events.

Nanoparticle Delivery of Innate Immune Agonists Combined with Senescence-Inducing Agents Promotes T Cell Control of Pancreatic Cancer

[Science Translational Medicine] Researchers investigated an immunotherapy approach combining delivery of stimulator of interferon genes and Toll-like receptor 4 innate immune agonists by lipid-based nanoparticle coencapsulation with senescence-inducing RAS-targeted therapies, which could remodel the immune suppressive PDAC tumor microenvironment through the senescence-associated secretory phenotype.

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Noshin Noorjahan

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