VEGF-Induced Nrdp1 Deficiency in Vascular Endothelial Cells Promotes Cancer Metastasis by Degrading Vascular Basement Membrane

Scientists showed that the conditional medium from hypoxia-incubated cancer cells induces extensive Nrdp1 downregulation in human and mouse vascular endothelial cells by VEGF, which activated CHIP, followed by Nrdp1 degradation in ubiquitin-proteasome-dependent way.