Endothelial Cell Expression of a STING Gain-of-Function Mutation Initiates Pulmonary Lymphocytic Infiltration

To identify STING-expressing non-hematopoietic cell types required for the development of interstitial lung disease, investigators used a conditional knockin STINGV154M (VM) mutation model and direct expression of the VM allele to hematopoietic cells, fibroblasts, epithelial cells, or endothelial cells.