Diosgenin Improves Post-myocardial Infarction Cardiac Function via HAND2-Induced Angiogenesis

Researchers revealed that diosgenin significantly improved cardiac function in a myocardial infarction mouse model, reducing cardiac fibrosis and cell apoptosis while promoting angiogenesis. Mechanistically, diosgenin upregulated the Hand2 expression, promoting the proliferation and migration of endothelial cells under hypoxic conditions.