Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension

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Researchers studied cyclophilin D (CypD) acetylation in patients with essential hypertension, defined a pathogenic role of CypD acetylation in deacetylation mimetic CypD-K166R mutant mice and endothelial-specific general control of amino acid synthesis 5 like 1–deficient mice using an angiotensin II model of hypertension.
[Circulation Research]
AbstractGraphical Abstract