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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Endothelial GDF15 Deficiency Enhances Barrier Function and Mitigates Pulmonary Fibrosis
[JCI Insight] Scientists demonstrated that plasma growth differentiation factor 15 (GDF15) is elevated across diverse fibrotic lung disease subtypes and correlates with markers of elevated right heart pressures, but not pulmonary function indices, indicating a possible link to endothelial cell dysfunction.
TGF-β Coordinates Alanine Synthesis and Import for Myofibroblast Differentiation in Pulmonary Fibrosis
[JCI Insight] Researchers identified alanine as an essential metabolite for myofibroblast differentiation. Transforming growth factor–β1 (TGF-β) increases intracellular alanine levels through enhanced synthesis and import in both normal and idiopathic pulmonary fibrosis lung fibroblasts.
Discovery and Evaluation of a PROTAC Degrader Targeting SAMHD1 for the Treatment of Pulmonary Fibrosis
[Journal of Medicinal Chemistry] The authors reported the discovery of NP12, the first SAMHD1 degrader with intracellular activity. In a bleomycin-induced pulmonary fibrosis mouse model, NP12 delayed pulmonary fibrosis progression and exerted a protective effect on lung tissue.
Long Isoforms of the COPD Risk Gene FAM13A Orchestrate Human Lung Epithelial Development
[American Journal of Respiratory Cell and Molecular Biology] Investigators demonstrated that the FAM13A long isoform is critical to patterning NKX2-1 + lung progenitor cells through dysregulating Wnt/β-catenin signaling during early stages of development in vitro.
Functionalised Thin Multi-Walled Carbon Nanotubes Are Less Toxic to Lung Cells In Vitro Than Their Native Counterparts
[Archives of Toxicology] Scientists investigated the induction of the epithelial-mesenchymal transition of human bronchial epithelial cells BEAS-2B following six weeks of treatment with multi-walled carbon nanotubes ranging from 0.125 to 1 µg/cm2.
A Ginsenoside Metabolite and Its Derivative Target PRELID3B against Lung Cancer Cells
[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed an efficacious compound K (CK) derivative, CKD-4 with significantly enhanced cancer cell penetration and cytotoxicity both in vitro and in vivo.
LDHC4 Drives Lung Adenocarcinoma Progression by Inducing Lactylation of RB1 at Lysine 900 to Disrupt the RB1-E2F1 Complex
[Journal of Translational Medicine] Scientists investigated whether lactate dehydrogenase C4 (LDHC4) promotes lung adenocarcinoma by modulating protein lactylation, a lactate-derived post-translational modification, focusing on the tumor suppressor retinoblastoma protein (RB1).
Emerging Role of SIRT1 in Asthma and COPD from Molecular Mechanisms to Translational Therapy
[iScience] The authors examines challenges, compare SIRT1's divergent roles, and evaluate chronotherapy, biomarker-guided selection, and SIRT1 activators.
Nuvation Bio Announces FDA Acceptance of Supplemental New Drug Application for IBTROZI® (taletrectinib) with Updated Duration of Response in Advanced ROS1-Positive Non-Small Cell...
[Nuvation Bio Inc. ] Nuvation Bio Inc. announced today that the US FDA has accepted a supplemental New Drug Application with updated data for IBTROZI® (taletrectinib) in both TKI-naïve and TKI-pretreated advanced ROS1-positive NSCLC.
LCRF Grants Team Science Award Focused on Curing EGFR-Mutant Lung Cancers
[The Lung Cancer Research Foundation] The Lung Cancer Research Foundation (LCRF) announces the first recipients of its LCRF Team Science Award on Advancing Therapies Toward Curing EGFR Mutated Lung Cancers.
Mitophagy Promotes Lung Repair and Regeneration by Restoring Epithelial Metabolic Fitness
[Nature Communications] Scientists demonstrated that genetic depletion of Ubiquitin Specific Peptidase 30, a negative regulator of mitophagy, boosts mitophagy and restores mitochondrial function in AT2 cells, leading to protection from injury-induced apoptosis and enhanced stem cell activity.
Vitamin D Attenuates the Progression of Pulmonary Fibrosis via Inhibiting Thymidine Kinase 1/PFKFB3-Driven Glycolysis
[Journal of Translational Medicine] MRC-5 cells and mouse primary lung fibroblasts treated with TGF-β1 combined with Vitamin D were used to explore the role of vitamin D on fibroblast activation and glycolysis in vitro.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
