Claudin-7 Is Essential for the Maintenance of Colonic Stem Cell Homoeostasis via the Modulation of Wnt/Notch Signalling

Researchers used intestinal epithelial cells- and intestinal stem cells-specific Cldn-7 knockout mice to investigate the regulatory effects of Cldn-7 on colonic Lgr5+ stem cells in the mediation of colonic epithelial injury and repair under physiological and inflammatory conditions.