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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
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The Germ Layer: Foundation of Mesenchymal Stem Cell Therapeutic Destiny
[Cell Death & Disease] The authors provide a systematic comparison of stem cells originating from the surface ectoderm, neural crest ectoderm, and mesoderm, highlighting their distinct molecular signatures, functional properties, and therapeutic utility.
Mesenchymal Stem Cells Protect against Diabetic Nephropathy through Gut Microbiota-Butyrate-Mediated Inhibition of Neutrophil Extracellular Traps
[Nutrition & Diabetes] Administration of MSCs, as well as fecal microbiota transplantation from MSC-treated donors, significantly ameliorated renal injury and suppressed neutrophil extracellular trap formation in diabetic nephropathy rats.
Mesenchymal Stromal Cells Immunosuppress Osteoarthritis Synovial Fluid Modulated Monocytes via IL-6 and CCL2
[Cell Death & Disease] Investigators hypothesized that MSC soluble factors, particularly interleukin-6 (IL-6) and C-C motif chemokine ligand (CCL2) modulate monocytes in knee osteoarthritis environment.
Cysteine Preconditioning Improves Post-Freeze-Thaw Proliferative Capacity of Human Synovial Mesenchymal Stem Cells
[Scientific Reports] Researchers examined whether cysteine preconditioning improves post-freeze–thaw proliferation and whether glutathione responsiveness is associated with donor-dependent variability.
Procr+ Endothelial Progenitor Cells Govern Hematopoiesis through Fine-Tuning Mesenchymal Stem Cell Niche Signals
[Blood] Investigators showed that protein C receptor–positive (Procr+) endothelial progenitor cells sustain vascular integrity and govern MSC-dependent hematopoietic stem cell maintenance, offering targeted clinical strategies for niche regeneration.
Engineering Injectable Alginate Hydrogels for Mesenchymal Stem Cell Delivery: Comparative Evaluation of Ionic Crosslinking Strategies and Early In Vitro Outcomes
[Biomedical Materials] Scientists investigated how three ionic crosslinking strategies-internal gelation, external gelation, and combined internal-external gelation-govern the material performance of alginate hydrogels engineered for human adipose-derived MSC delivery.
Single-Cell Profiling Uncovers a Rare Mesenchymal-Like Urothelial State Associated with Sarcomatoid Bladder Cancer
[Cell Death & Disease] Researchers identified and characterized a rare population of mesenchymal-like urothelial cells, termed M-cells, representing approximately 1–3% of urothelial cells. M-cells co-express epithelial markers with mesenchymal and stemness genes and engage stem cell-associated transcriptional regulators.
Fannin Receives CDMRP and Faris Foundation Grants to Advance Targeted RapDC Therapy for Ewing Sarcoma
[Fannin Partners, LLC (PR Newswire)] Fannin Partners, LLC today announced two new grants from the Congressionally Directed Medical Research Programs (CDMRP) and the Faris Foundation to advance development of a targeted Raptamer-Drug Conjugate (RapDC) therapy for Ewing sarcoma
Ultrashort Wave Therapy Promotes the Repair of Jaw Defect by Regulating the Function of Jaw Bone Marrow Mesenchymal Stromal Cells
[Scientific Reports] Researchers evaluated the effect of ultrashort wave therapy on enhancing jaw bone marrow MSC function and promoting mandibular repair.
Mesenchymal Stromal/Stem Cells in Inflammatory Bowel Disease: Crosstalk with Innate and Adaptive Immunity
[European Journal of Pharmacology] The authors summarize the therapeutic significance of MSCs for inflammatory bowel disease in the context of their interactions with various innate and adaptive immune cells, including neutrophils, monocytes/macrophages, dendritic cells, natural killer cells, B lymphocytes, and T lymphocytes.
Intravenous Placenta-Derived Mesenchymal Stem Cells Enhance Early Survival As an Adjunct to Supportive Care in Severe Burn: A Preclinical Study
[Stem Cell Research & Therapy] Investigators proposed that placenta-derived choriodecidual MSCs may confer an additive survival benefit after severe burn injury, particularly under inadequate fluid resuscitation and thermal support.
Enhancing Pulp Regeneration through Metabolic Reprogramming of Mature Dental Pulp Stem Cells Mediated by GLUT1/HK2 mRNA Delivery
[International Journal of Oral Science] Investigators demonstrated that highly branched poly(β-amino ester)-mediated metabolic reprogramming effectively rejuvenates mature dental pulp stem cells by restoring the metabolic-ECM-angiogenesis axis.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
