Newsletters

[Nature Communications] Scientists identified the stress kinase p38β (MAPK11) supports tumor-initiating cell maintenance and drug resistance in hepatocellular carcinoma (HCC). Integrated analysis of chemotherapy-enriched HCC spheroids, and DepMap data prioritized p38β as a kinase linked to stemness and chemoresistance.

[The Den] Mercer University School of Medicine has been awarded the fifth annual Collaborative Cancer Research Seed Grant of $100,000 to advance research aimed at improving treatment for one of the most aggressive forms of endometrial cancer. This grant will support a research project led by Dr. Ilana Chefetz Menaker.

[Queen's Gazette] 13 research teams at Queen’s University have received a combined $12.7 million from the Canadian Institutes of Health Research (CIHR). Awarded through CIHR's Project Grant: Spring 2026 competition, each project will work towards advancing the wellbeing of Canadians through translational research.

[Stem Cell Reviews and Reports] The authors summarize current nanotechnology-enabled strategies targeting lung cancer stem cells, with particular emphasis on tumor microenvironment remodeling, metabolic regulation, and tumor immunity.

[International Journal of Clinical Oncology] Since CSCs are the major cause of metastatic spread, emerging therapeutic modalities specifically targeting CSCs present a lucrative approach to curtail metastatic disease.

[Advanced Science] Researchers identifeid WD repeat domain 72 (WDR72) as a cancer stem cell marker that significantly correlates with high-risk of neuroblastoma and poor prognosis in neuroblastoma patients.

[Nature Cell Biology] Investigators used a fluorescent reporter that marks CSCs to show that CSCs and their more differentiated progeny display strikingly different population dynamics during metastatic lung colonization in breast cancer models.

[Acta Pharmacologica Sinica] Using triple negative breast cancer cell lines (TNBC) and CSCs enriched from these cell lines scientists revealed that the PD-1/PD-L1 pathway predominantly mediates CSC-driven immune evasion, growth, and metastasis in TNBC.

[Oncogene] Researchers identified the histone methyltransferase KMT5C as master regulator of hepatocellular carcinoma stemness and progression through integrative analyses of patient-derived organoids, murine models, and clinical cohorts.

[Journal of Advanced Research] Lineage tracing experiments revealed that Hopx+ quiescent stem cell subpopulation exhibited an enhanced regeneration, which functionally drove the recurrence of rectal cancer after irradiation.

[Acta Neuropathologica] Researchers established and extensively characterized four astrocytoma cell lines derived from IDH-mutant astrocytomas of different grades and analyzed them using multi-omics approaches.

[Science Advances] Using lipidomic profiling by mass spectrometry, investigators identified age-related changes in complex lipids in quiescent neural stem cells in vitro and in vivo.