Newsletters

[Nature Nanotechnology] Through an in vitro screening of gut microbial metabolites, scientists identified 3,4-dihydroxybenzoic acid that improved adoptive T cell therapy and enhanced CD8+ T cell stemness by suppressing glycolysis and regulating the Akt-mTORC1-Myc pathway.

[Acta Biomaterialia] Investigators reported a living biohybrid strategy that simultaneously regulates lipid metabolism and oxygen availability to reprogram the TNBC microenvironment.

[Cancer Research] Scientists generated an extensive mouse model dataset comprised of 26 immunocompetent mammary tumor models spanning diverse genetic backgrounds, epithelial–mesenchymal states, the basal–luminal axis, and distinct immune microenvironments.

[Cell Death & Disease] The authors provide a systematic comparison of stem cells originating from the surface ectoderm, neural crest ectoderm, and mesoderm, highlighting their distinct molecular signatures, functional properties, and therapeutic utility.

[Nutrition & Diabetes] Administration of MSCs, as well as fecal microbiota transplantation from MSC-treated donors, significantly ameliorated renal injury and suppressed neutrophil extracellular trap formation in diabetic nephropathy rats.

[Cell Death & Disease] Investigators hypothesized that MSC soluble factors, particularly interleukin-6 (IL-6) and C-C motif chemokine ligand (CCL2) modulate monocytes in knee osteoarthritis environment.

[Scientific Reports] Researchers examined whether cysteine preconditioning improves post-freeze–thaw proliferation and whether glutathione responsiveness is associated with donor-dependent variability.

[Blood] Investigators showed that protein C receptor–positive (Procr+) endothelial progenitor cells sustain vascular integrity and govern MSC-dependent hematopoietic stem cell maintenance, offering targeted clinical strategies for niche regeneration.

[Biomedical Materials] Scientists investigated how three ionic crosslinking strategies-internal gelation, external gelation, and combined internal-external gelation-govern the material performance of alginate hydrogels engineered for human adipose-derived MSC delivery.

[Cell Death & Disease] Researchers identified and characterized a rare population of mesenchymal-like urothelial cells, termed M-cells, representing approximately 1–3% of urothelial cells. M-cells co-express epithelial markers with mesenchymal and stemness genes and engage stem cell-associated transcriptional regulators.

[Fannin Partners, LLC (PR Newswire)] Fannin Partners, LLC today announced two new grants from the Congressionally Directed Medical Research Programs (CDMRP) and the Faris Foundation to advance development of a targeted Raptamer-Drug Conjugate (RapDC) therapy for Ewing sarcoma

[Experimental & Molecular Medicine] Investigators developed a CAR-like signal-switching receptor-macrophage that recognizes IL-10, a major immunosuppressive cytokine enriched in solid tumors, and converts this inhibitory signal into a pro-inflammatory activation through the Toll-like receptor 9 (TLR9) intracellular signaling pathway.