Jamie Kang

Hematopoiesis News

Impact of the Time Interval between End of Induction and Autologous Hematopoietic Transplantation in Newly Diagnosed Patients with Multiple Myeloma

[Bone Marrow Transplantation] Researchers evaluated the impact of the time interval between end of induction and autologous hematopoietic transplantation on progression-free survival and overall survival in multiple myeloma patients.

Hematopoiesis News

DDX41 Coordinates RNA Splicing and Transcriptional Elongation to Prevent DNA Replication Stress in Hematopoietic Cells

[Leukemia] Scientists demonstrated that loss of DEAD-Box Helicase 41 (DDX41) function impaired efficient RNA splicing, resulting in DNA replication stress with excess R-loop formation in hematopoietic cells.

Hematopoiesis News

Health-Related Quality of Life in Reduced Intensity Hematopoietic Cell Transplantation Based on Donor Availability in Patients Aged 50–75 with Advanced Myelodysplastic Syndrome: BMT CTN...

[American Journal of Hematology] The primary analysis of this Blood and Marrow Transplant Clinical Trials Network study showed the survival advantage associated with allogeneic hematopoietic cell transplantation in older adults with myelodysplastic syndromes did not come at the cost of worse quality of life.

Hematopoiesis News

Real World Outcomes in Patients with Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Undergoing Allogeneic Stem Cell Transplantation–a Single Institution Experience

[International Journal of Cancer] Researchers performed a retrospective cohort study of Ph+ acute lymphoblastic leukemia patients who received tyrosine kinase inhibitor therapy pre- and post-allogeneic hematopoietic stem cell transplant from April 2007 to November 2019.

Hematopoiesis News

Comprehensive Review on Allogeneic Stem Cell Transplantation for Patients with Myelodysplastic Syndromes

[American Journal of Hematology] The authors provide a comprehensive summary of the recent challenges and developments in allogeneic hematopoietic stem cell transplantation as a curative treatment for myelodysplastic syndromes, primarily affecting older persons.

Hematopoiesis News

Gene Editing in Human Hematopoietic Stem Cells for the Treatment of Primary Immunodeficiencies

[Molecular Diagnosis & Therapy] Investigators discuss the methods of transplantation of genetically edited human hematopoietic stem cells being explored and describe progress made so far with several primary immunodeficiencies.

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circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

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Jamie Kang

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