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Jamie Kang

Crypt-Villus Scaffold Architecture for Bioengineering Functional Human Intestinal Epithelium

[ACS Biomaterials Science & Engineering] Scientists utilized 3D printing and inverse molding techniques to form 3D spongy scaffold systems that resemble the intestinal crypt-villus microarchitecture.

Morin Inhibits Colon Cancer Stem Cells by Inhibiting PUM1 Expression In Vitro

[Medical Oncology] The authors tested the potency of morin to inhibit cancer stem cells. They found that morin has significantly reduced colon cancer cell proliferation, colony formation, migration, and colonospheroid formation in a dose-dependent manner.

Constructed the ceRNA Network and Predicted a FEZF1-AS1/miR-92b-3p/ZIC5 Axis in Colon Cancer

[Molecular and Cellular Biochemistry] Researchers studied the FEZF1-AS1/miR-92b-3p/ZIC5 axis. They detected the expression of FEZF1-AS1, miR-92b-3p, and ZIC5 via quantitative reverse transcription-PCR, transfected colon cancer cell RKO with lentivirus and conducted FEZF1-AS1 knockdown, and performed cancer-related functional assays.

Signaling Pathways and Therapeutic Interventions in Gastric Cancer

[Signal Transduction and Targeted Therapy] The authors review the regulatory roles of signaling pathways in gastric cancer potential biomarkers, and therapeutic targets with an emphasis on recent discoveries.

Neurotransmitter Signaling: A New Frontier in Colorectal Cancer Biology and Treatment

[Oncogene] Investigators present an overview of the current evidence supporting the role of neurotransmitters in colorectal cancer biology and treatment.

United Therapeutics Announces First Patient Enrolled in Phase III TETON 2 Study of Tyvaso in Patients with Idiopathic Pulmonary Fibrosis

[United Therapeutics Corporation] United Therapeutics Corporation announced that the first patient has enrolled in the Phase III TETON2 study which will evaluate Tyvaso in 396 adult patients with idiopathic pulmonary fibrosis at sites outside the United States and Canada.

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Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.