Jamie Kang

Cell Therapy News

Mechanism of Action, Potency and Efficacy: Considerations for Cell Therapies

[Journal Of Translational Medicine] A logical framework for thinking about mechanism of action, potency and efficacy is presented that is consistent with the existing regulatory guidelines, but also accommodates what has been learned from the 27 US FDA-approved cell therapy products.

Endothelial Cell News

CCL4 Contributes to Aging Related Angiogenic Insufficiency through Activating Oxidative Stress and Endothelial Inflammation

[Angiogenesis] Scientists hypothesized that chemokine C-C motif ligands 4 (CCL4) might play a vital role in aging-related vascular dysfunction. Circulating CCL4 was up-regulated in elderly subjects and in aged animals.

Endothelial Cell News

Engineered Nanomicelles Targeting Proliferation and Angiogenesis Inhibit Tumour Progression by Impairing the Synthesis of Ceramide-1-Phosphate

[Nanoscale] Researchers engineered sub-100 sized nanomicelles targeting proliferation and angiogenesis using an esterase-sensitive phosphocholine-tethered docetaxel conjugate of lithocholic acid (LCA) and a poly(ethylene glycol) derivative of an LCA–combretastatin A4 conjugate.

Endothelial Cell News

Estrogen Stimulates Fetal Vascular Endothelial Growth Factor Expression and Microvascularization

[Journal Of Endocrinology] Investigators showed that estrogen upregulates skeletal muscle VEGF expression and systemic microvessel development within the fetus as an essential programming event critical for ontogenesis of systemic vascular function and insulin sensitivity/glucose homeostasis after birth in primate offspring.

Endothelial Cell News

New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases

[Journal Of Histochemistry & Cytochemistry] During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) produce lactate and ATP by aerobic glycolysis. Local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation.

Immune Regulation News

HDAC Inhibition Increases CXCL12 Secretion to Recruit Natural Killer Cells in Peripheral T Cell Lymphoma

[Cancer Research] Researchers found that high expression of histone deacetylase (HDAC)3 was associated with poor prognosis in peripheral T cell lymphoma. HDAC3 inhibition suppressed lymphoma growth in immunocompetent mice but not in immunodeficient mice.

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GLUT1 Overexpression Enhances CAR T Cell Metabolic Fitness and Anti-Tumor Efficacy

[Molecular Therapy] Using mouse models of acute lymphoblastic leukemia (ALL), renal cell carcinoma (RCC), and glioblastoma (GBM), we show that enforced expression of the glucose transporter GLUT1 enhances anti-tumor efficacy and promotes favorable CAR T cell phenotypes for two clinically relevant CAR designs, 19-28z and IL13Rα2-BBz.

BCKDK Modification Enhances the Anticancer Efficacy of CAR-T Cells by Reprogramming Branched Chain Amino Acid Metabolism

[Molecular Therapy] Investigators evaluated the efficacy of CAR T cell-mediated cancer cell lysis potential in the immune microenvironment of Branched Chain Amino Acids supplementation and deletion.

Targeting TGFβ-Activated Kinase-1 Activation in Microglia Reduces CAR T Immune Effector Cell-Associated Neurotoxicity Syndrome

[Nature Cancer] Researchers examined the role of microglia using mouse models and cohorts of individuals with ICANS. CD19-directed CAR (CAR19) T cell transfer in B cell lymphoma-bearing mice caused microglia activation and neurocognitive deficits.

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Jamie Kang

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