Jamie Kang

[Nature Communications] Scientists investigated the effect of Amuc_1098 on acute pancreatitis in mice induced by caerulein combined with lipopolysaccharide or L-arginine.

[iScience] Investigators conducted a phosphoproteomics analysis to evaluate phosphorylation levels, and administered extracellular vesicles derived from human adipose mesenchymal stem cells in a mouse model of severe acute pancreatitis and assessed their impact on Treg differentiation.

[Molecular Cancer] The authors investigated the mechanisms underlying the interaction and influence between microvascular invasion, which contributes to metastasis and poor prognosis of PDAC, and the tumor microenvironment.

[Journal for Immunotherapy of Cancer] Researchers demonstrated that relaxin can enhance intratumoral accumulation of programmed death-ligand 1-targeted RIT (lutetium-177-labeled atezolizumab) in a multifaceted manner to elicit synergistic antitumor immune response against desmoplastic and poorly immunogenic pancreatic tumors.

[Cell Death & Disease] Scientists utilized molecular cytology techniques, animal models, and human pancreatic cancer tissues to investigate the role of FoxM1 in Smad4 stabilization and its regulation of TGF-β signaling.

[Cancer & Metabolism] Investigators suggested that SRRM1 may serve as a predictive biomarker for gemcitabine (GEM) response in pancreatic cancer. Targeting SRRM1 in conjunction with ferroptosis inducers could offer a promising strategy to overcome GEM resistance.