KDM4B/DHX9 Promotes Chemoresistance in Small-Cell Lung Cancer through the MYCN-Driven Signaling Pathway

Researchers identified KDM4B as a key driver of chemoresistance, with immunohistochemical analysis revealing its elevated expression in chemoresistant tissues from small cell lung cancer patients. KDM4B promoted chemoresistance through the Hedgehog pathway by enhancing cell proliferation and stemness.