Emily Salmini

[Science Advances] By combining cellular and transcriptomic approaches, researchers showed that common CD8+ T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional skin of patients with vitiligo.

[Immunity] Investigators examined the heterogeneity of tumoral Treg cells in colorectal cancer and identified two distinct tumoral Treg subsets with differential Il10 expression.

[iScience] Through in vitro and in vivo approaches, scientists demonstrated that Dinutuximab beta effectively suppressed tumor growth by 60% and improved survival rate by 68% in a mouse model xenograft.

[Cell Reports] The authors used hPSC-derived cerebral organoids and human telencephalic assembloids to model early cortical development in the context of MeCP2 deficiency.

[British Journal of Cancer] Scientists performed a single-cell assay for transposase-accessible chromatin with high-throughput sequencing and single-cell RNA sequencing on pancreas tissues from KPC mice characterise myofibroblastic cancer-associated fibroblast heterogeneity.

[Journal of Translational Medicine] The authors review the preclinical and clinical advancements in the understanding of the therapeutic properties of MSCs and their subpopulations, assessing the evidence supporting their use in regenerative medicine.