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e.g. organoids

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Emily Salmini

Cancer Stem Cell News

Nanotechnology-Enabled Precision Targeting of Lung Cancer Stem Cells: Recent Developments and Therapeutic Implications

[Stem Cell Reviews and Reports] The authors summarize current nanotechnology-enabled strategies targeting lung cancer stem cells, with particular emphasis on tumor microenvironment remodeling, metabolic regulation, and tumor immunity.
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Cancer Stem Cell News

Current Therapeutic Interventions to Target Cancer Stem Cells for Metastasis

[International Journal of Clinical Oncology] Since CSCs are the major cause of metastatic spread, emerging therapeutic modalities specifically targeting CSCs present a lucrative approach to curtail metastatic disease.
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Cancer Stem Cell News

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31-Mediated Degradation of CBX8

[Advanced Science] Researchers identifeid WD repeat domain 72 (WDR72) as a cancer stem cell marker that significantly correlates with high-risk of neuroblastoma and poor prognosis in neuroblastoma patients.
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Cancer Stem Cell News

Cancer Stem Cells Are Hyper-Responsive Sensors of the Tumor Microenvironment and Regulate Metastasis Dynamics through YAP/TAZ

[Nature Cell Biology] Investigators used a fluorescent reporter that marks CSCs to show that CSCs and their more differentiated progeny display strikingly different population dynamics during metastatic lung colonization in breast cancer models.
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Cancer Stem Cell News

Dopamine Abrogates Immunosuppression Mediated by PD-L1 of Cancer Stem Cells in a Preclinical Triple-Negative Breast Cancer Model

[Acta Pharmacologica Sinica] Using triple negative breast cancer cell lines (TNBC) and CSCs enriched from these cell lines scientists revealed that the PD-1/PD-L1 pathway predominantly mediates CSC-driven immune evasion, growth, and metastasis in TNBC.
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Cancer Stem Cell News

The Epigenetic KMT5C-HDAC1 Axis Promotes Hepatocellular Carcinoma Stemness and Progression through SERPINA4 Repression and Chromatin Compaction

[Oncogene] Researchers identified the histone methyltransferase KMT5C as master regulator of hepatocellular carcinoma stemness and progression through integrative analyses of patient-derived organoids, murine models, and clinical cohorts.
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P38β-mediated BiP Phosphorylation Drives Stemness and Chemoresistance by Suppressing UPR Activation in Hepatocellular Carcinoma

[Nature Communications] Scientists identified the stress kinase p38β (MAPK11) supports tumor-initiating cell maintenance and drug resistance in hepatocellular carcinoma (HCC). Integrated analysis of chemotherapy-enriched HCC spheroids, and DepMap data prioritized p38β as a kinase linked to stemness and chemoresistance.

Mercer School of Medicine Awarded $100,000 Cancer Research Grant

[The Den] Mercer University School of Medicine has been awarded the fifth annual Collaborative Cancer Research Seed Grant of $100,000 to advance research aimed at improving treatment for one of the most aggressive forms of endometrial cancer. This grant will support a research project led by Dr. Ilana Chefetz Menaker.

$12.7 Million for Cancer, Heart, and Health Research

[Queen's Gazette] 13 research teams at Queen’s University have received a combined $12.7 million from the Canadian Institutes of Health Research (CIHR). Awarded through CIHR's Project Grant: Spring 2026 competition, each project will work towards advancing the wellbeing of Canadians through translational research.
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