Emily Salmini

[Nature Communications] The Src family kinase Lyn is known to be involved in the induction and maintenance of peripheral B cell tolerance. Scientists utilized a system in which Lyn deletion is tamoxifen inducible and B cell restricted, which allows acute elimination of Lyn in B cells only, minimizing confounding factors.

[Oncoimmunology] The authors underscore a dual role for B cells in melanoma, supporting antitumor immunity or promoting immune escape, and highlight opportunities to target regulatory B cells, correct isotype imbalance, and leverage B cell signatures as biomarkers.

[Science Immunology] Researchers found that epitopes derived from seed storage proteins are targets of murine intestinal Treg cells, with the most frequent response targeting the C terminus of the maize protein alpha-zein.

[Genes and Immunity] Scientists provide a comprehensive analysis of the immune imbalance of allergic rhinitis, focusing on the key role of Th17/Treg cell imbalance in the pathogenesis of diseases.

[Mbio] Using the intestinal mucosa as a paradigm, scientists explore how the gut microenvironment fosters the generation of tolerogenic antigen-presenting cells and microbe-specific Tregs to enforce immunological tolerance.

[Nature Medicine] The authors highlight insights from recent clinical trials, translational studies and preclinical models, which reveal critical factors for optimizing cancer vaccines.