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Emily Salmini

TRIM58 Downregulation Maintains Stemness via MYH9-GRK3-YAP Axis Activation in Triple-Negative Breast Cancer Stem Cells

[Cancer Gene Therapy] Investigators reported that TRIM58 was underexpressed in TNBC tissues and cells compared to adjacent mucosa tissue, and its downregulation was significantly associated with shorter survival.

Positive Feedback Regulation between Glycolysis and Histone Lactylation Drives Oncogenesis in Pancreatic Ductal Adenocarcinoma

[Molecular Cancer] The participation of histone lactylation in the growth and progression of PDAC was confirmed through inhibition of histone lactylation by glycolysis inhibitors or lactate dehydrogenase A knockdown both in vitro and in vivo.

Dr. Timothy Ryan Elected to National Academy of Sciences

[Weill Cornell Medicine] Dr. Timothy Ryan, professor of biochemistry in anesthesiology at Weill Cornell Medicine, has been elected to the National Academy of Sciences, one of the highest honors a scientist can receive.

Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29 T

[Applied Biochemistry And Biotechnology] A bacterial EPS from the marine bacterium Halomonas malpeensis YU-PRIM-29T was used to treat the burn wound in vivo. In vitro biocompatibility of EPS-H29 was studied in human dermal fibroblasts and keratinocytes.

Dab2 (Disabled-2), an Adaptor Protein, Regulates Self-Renewal of Hair Follicle Stem Cells

[Communications Biology] Investigators reported that Dab2 conditional knockout mice exhibited a delay in the hair follicle cycle due to perturbed activation of hair follicle stem cells.

Acinar to β-Like Cell Conversion through Inhibition of Focal Adhesion Kinase

[Nature Communications] Using lineage tracing studies along with transcriptomic characterization, scientists demonstrated that treatment of adult mice with a small molecule that inhibits kinase activity of focal adhesion kinase resulted in trans-differentiation of a subset of peri-islet acinar cells into insulin producing β-like cells.

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Local and Global Changes in Cell Density Induce Reorganization of 3D Packing in a Proliferating Epithelium

[Development] Investigators used live imaging of the sea star embryo coupled with deep learning-based segmentation to dissect the relative contributions of cell density, tissue compaction, and cell proliferation on epithelial architecture.

Generation of Allogenic and Xenogeneic Functional Muscle Stem Cells for Intramuscular Transplantation

[Journal Of Clinical Investigation] The authors investigated whether satellite cells could be derived in allogeneic or xenogeneic animal hosts.

A Mitochondrial Surveillance Mechanism Activated by SRSF2 Mutations in Hematologic Malignancies

[Journal Of Clinical Investigation] Scientists showed that the pathogenic SRSF2P95H/+ mutation disrupted the splicing of mitochondrial mRNAs, impaired mitochondrial complex I function, and robustly increased mitophagy.