Emily Salmini

Endothelial Cell News

Meningeal Lymphatic Drainage: Novel Insights into Central Nervous System Disease

[Signal Transduction and Targeted Therapy] Scientists provide direction for future research and therapeutic strategies targeting meningeal lymphatics by critically analyzing recent advancements in the field, identifying gaps in current knowledge, and proposing innovative approaches to address these gaps.

Endothelial Cell News

Bispecific vs. Bispecific: Innovent Announces First Patient Dosed in the Phase II Clinical Study of Efdamrofusp Alfa, a First-In-Class Anti-VEGF and Anti-Complement Bispecific Fusion...

[Innovent Biologics, Inc.] Innovent Biologics, Inc. accounced the completion of first patient dosing in the Phase II clinical study of efdamrofusp alfa, a recombinant human VEGFR-antibody human complement receptor 1 fusion protein, for the treatment of diabetic macular edema.

Endothelial Cell News

Typhoid Toxin Causes Neuropathology by Disrupting the Blood-Brain Barrier

[Nature Microbiology] Utilizing mice engineered to have specific tissues protected from toxin action and an in vitro model of the blood–brain barrier (BBB), researchers demonstrated that, rather than direct action on neuronal or glial cells, typhoid toxin causes neuropathology by disrupting the BBB.

Endothelial Cell News

Endothelial Major Vault Protein Alleviates Vascular Remodeling via Promoting Parkin-Mediated Mitophagy

[Nature Communications] The authors investigated the regulatory role of major vault protein in the pathogenesis of vascular remodeling via controlling endothelial cell injury.

Endothelial Cell News

Highly Conserved Brain Vascular Receptor ALPL Mediates Transport of Engineered AAV Vectors across the Blood-Brain Barrier

[Molecular Therapy] Researchers applied an RNA-guided TRACER adeno-associated virus (AAV) capsid evolution platform to generate VCAP-102, an AAV9 variant with markedly increased brain tropism following intravenous delivery in both rodents and primates.

Endothelial Cell News

DDX24 Spatiotemporally Orchestrates VEGF and Wnt Signaling during Developmental Angiogenesis

[Proceedings of The National Academy of Sciences of The United States of America] Investigators demonstrated the pivotal role of DEAD-box RNA helicase 24 (DDX24) in the regulation of vascular development in the brain and trunk. Ddx24 deficiency in zebrafish results in ectopic vessel sprouting in the trunk but inhibits angiogenesis in the brain.

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An Integrated Transcriptomic Cell Atlas of Human Endoderm-Derived Organoids

[Nature Genetics] Researchers integrated single-cell transcriptomes from 218 samples covering organoids and other models of diverse endoderm-derived tissues to establish an initial version of a human endoderm-derived organoid cell atlas.

Organoid Morphology-Guided Classification for Oral Cancer Reveals Prognosis

[Cell Reports Medicine] Scientists presented a pioneering approach to classifying oral cancer subtypes based on the morphology of patient-derived organoids and proposed a therapeutic strategy.

Immunotherapy-Related Cognitive Impairment after CAR T Cell Therapy in Mice

[Cell] Investigators demonstrated in mouse models that CAR T cell therapy for both central nervous system and non-CNS cancers impaire cognitive function and induced a persistent CNS immune response characterized by white matter microglial reactivity, microglial chemokine expression, and elevated cerebrospinal fluid cytokines and chemokines.

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Emily Salmini

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