Emily Salmini

Muscle Cell News

Cardiomyocyte-Specific Depletion of Integrin α3 Preserves Cardiac Function after Myocardial Infarction

[Basic Research in Cardiology] To evaluate the role of Integrin α3 (ITGA3) in vivo, scientists generated a mouse line with cardiomyocyte-specific ITGA3 depletion (ITGA3 KO). ITGA3 KO mice were characterized under baseline conditions and after permanent LAD ligation by echocardiography.

Muscle Cell News

Multiscale Analysis and Functional Validation of the Cellular and Genetic Determinants of Skeletal Disease

[Nature Genetics] Researchers exploited the value of cross-species analysis and developed single-cell methodologies in skeletal tissues to define the critical endosteal compartment that regulates bone turnover.

Muscle Cell News

The Formin Fhod3 Is Required for Sarcomere Reassembly after Mitosis in Postnatal Cardiomyocytes

[Cellular and Molecular Life Sciences] Investigators examined the effects of Fhod3 depletion in primary cultured cardiomyocytes derived from Fhod3flox neonates. Long-range time-lapse imaging revealed that Fhod3 depletion around birth using muscle creatine kinase-Cre caused sarcomere disruption only in cells that had undergone mitosis.

Muscle Cell News

An H3K18la-ALKBH5-Runx2-LDHA Positive Feedback Loop Promotes Vascular Calcification in the Osteogenic Phenotypic Transition of Vascular Smooth Muscle Cells

[Cellular Signalling] Scientists confirmed that histone H3 lysine 18 lactylation (H3K18la) is abnormally elevated in osteogenic vascular smooth muscle cells. They demonstrated that H3K18la directly binds to the promoter region of AlkB homolog 5 (ALKBH5) and positively regulates its transcription.

Muscle Cell News

USP18 Regulates Skeletal Muscle Regeneration Independently of Its deISGylation Activity

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] USP18 acts as a context-dependent regulator of muscle regeneration independent of its deISGylation function. The authors identified USP18 as a dual modulator of myogenesis and highlighted its potential as a therapeutic target in inflammatory muscle disease.

Muscle Cell News

Epicrispr Completes Enrollment and Dose Escalation in First-in-Human EPI-321 Trial for FSHD

[Epicrispr Biotechnologies] Epicrispr Biotechnologies announced the completion of enrollment and dosing in the dose-escalation portion of its first-in-human clinical trial evaluating EPI-321 for facioscapulohumeral muscular dystrophy.

12 3...876 Page 1 of 876

ALOX15 Orchestrates Mitochondrial Antiviral Immunity and Serves As a Host Target for Anti-Influenza Therapy

[Nature Immunology] Researchers identified stress-responsive protein arachidonate lipoxygenase-15 (ALOX15) is a critical component of mitochondrial antiviral innate immunity.

Molecular evidence of neuroinvasive Sindbis virus infection in humans: detection in cerebrospinal fluid by next generation sequencing.

[Emerging Microbes & Infections] Investigators provided the first unequivocal evidence of human CNS involvement by detecting Sindbis virus RNA directly in the cerebrospinal fluid of four autochthonous patients presenting with acute neurological symptoms in south eastern Tuscany, Italy, July-August 2025.

Impaired IFNγ Responsiveness of Monocyte-Derived Lung Cells Limits Immunity to Mycobacterium Tuberculosis

[Nature Communications] Scientists showed that CD11c^lo monocyte-derived cells, the subset of lung cells that is most permissive for Mtb viability during chronic infection, express lower levels of interferon-gamma (IFNγ) signaling proteins, resulting in reduced responses to IFNγ compared to alveolar macrophages and CD11c^hi monocyte-derived cells.

All Articles by Author:

Emily Salmini

Popular