All Articles by Author:

Emily Salmini

MLKL, a New Actor of UVB-Induced Apoptosis in Human Diploid Dermal Fibroblasts

[Cell Death Discovery] Investigators evaluated the implication of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) in ultraviolet radiation (UV) B-induced cell death in human diploid dermal fibroblasts, and reported that RIPK3 and MLKL played opposite roles in UVB-induced cell death, in a necroptosis independent pathway.

Dermal Dive: An Overview of Cutaneous Wounding Techniques in Zebrafish

[Journal Of Investigative Dermatology] Scientists review some of the techniques that have been developed for eliciting cutaneous wounds in the zebrafish, including an economical method they recently developed using a rotary tool that generates consistent and reproducible full-thickness wounds.

Sympathetic Nerve Signals: Orchestrators of Mammary Development and Stem Cell Vitality

[Journal Of Molecular Cell Biology] Using a mouse mammary gland model, investigators delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development.

Resf1 Is a Compound G4 Quadruplex-Associated Tumor Suppressor for Triple Negative Breast Cancer

[PLOS Genetics] Researchers identified Resf1 as a novel metastasis susceptibility gene in ER- breast cancer. Reduction of Resf1 resulted in a significant increase in tumor growth, a shortened overall survival time, and increased incidence and number of lung metastases, consistent with patient data.

WDR61 Ablation Triggers R-Loop Accumulation and Suppresses Breast Cancer Progression

[FEBS Journal] Researchers elucidated the role of WDR61 in breast tumor development, and reported that knockdown of WDR61 compromised the proliferation of breast tumor cells with reduced colony-forming capacity.

A Comprehensive Overview of Metaplastic Breast Cancer: Features and Treatments

[Cancer Science] The authors provide a comprehensive review on the clinical features, molecular characteristics, invasion and metastasis patterns, and prognosis of metaplastic breast cancer, as well as recent advancements in treatment strategies.


Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.