Emily Salmini

[Journal of Experimental & Clinical Cancer Research] Scientists investigated the effect of dysmetabolism on pancreatic ductal adenocarcinoma (PDAC) development in a pre-clinical PDAC model with a specific focus on the stromal compartment.

[Advances in Nutrition] The authors examine the mechanistic pathways through which dietary fatty acids and sugars contribute the development of hepatic inflammation and fibrosis, offering a nuanced understanding of their respective roles in metabolic dysfunction-associated steatotic liver disease progression.

[Advanced Healthcare Materials] Scientists introduced a modular hydrogel system featuring a small peptide sequence that was selectively cleaved by the coagulation factor FXa. In a cell culture environment, where active FXa was absent, the hydrogel remained stable, providing a conducive matrix for the growth of tissue structures or organoid.

[Gut] Emerging data indicate that steatosis can be present in children under six years of age. The intricate interplay of genetics may inform future therapeutics and prognostication, with the PNPLA3 gene showing the most evidence for association with the risk and severity of steatotic liver disease and steatohepatitis.

[Journal of Experimental & Clinical Cancer Research] Researchers investigated the role of triggering receptor expressed on myeloid cells 2 (TREM2+) macrophages in various mouse HCC models. They investigated the role of TREM2+ macrophages in promoting the malignant phenotypes of HCC cells.

[Frontiers In Oncology] The authors discuss the dual role mitophagy plays in AML survival, the importance of targeting mitophagy to treat AML, and current progress in the area.