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Emily Salmini

Immunology of Infectious Disease News

Type I Interferon Mitigates ZIKV-Induced Neuroinflammation and Cell Death in the Central Nervous System

[Virus Research] Researchers investigated how type I interferon signaling influences the cellular inflammatory response and immunopathology in the central nervous system during ZIKV infection.
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Immunology of Infectious Disease News

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

[Advanced Science] Scientists identified viral ORF9b as a conserved accessory protein across the Sarbecovirus subgenus that consistently suppresses innate immune responses by recruiting the protein phosphatase, Mg2+/Mn2+-dependent 1A (PPM1A).
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Immunology of Infectious Disease News

Eosinophil-Driven Immunopathology Exacerbates SARS-CoV-2 Pneumonia in an OVA-Induced Airway Allergy Mouse Model

[Msphere] To investigate how allergic airway inflammation affects SARS-CoV-2-induced pneumonia, researchers used an ovalbumin-induced airway allergy mouse model and infected mice with QHmusX, a mouse-passaged SARS-CoV-2 strain that causes severe acute pneumonia.
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Immunology of Infectious Disease News

Nanomedicine Pioneer Awarded MacArthur ‘Genius Grant’

[UC San Diego Today] Dr. Liangfang Zhang has defined his career by creating cell-mimicking nanoparticles to treat disease. For creating this technology, and pioneering its development toward potential treatment infectious diseases and inflammatory disorders, Dr. Zhang has been named a 2026 MacArthur Fellow from the John D. and Catherine T. MacArthur Foundation.
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ESC & iPSC News

Systematic Transcriptomic Evaluation of Blastoid Models of Early Human Development

[Cell Systems] The authors established a reference map of cell identity and lineage differentiation of the human blastocysts through the integration and curation of single-cell transcriptome data of ex vivo blastocysts profiled at a range of developmental time points in culture.
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ESC & iPSC News

Chemical Screening Identifies Danofloxacin As a Self-Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1-Mediated Deacetylation of Tert and Prdm1

[Advanced Science] Through compound library screening, researchers identified Danofloxacin, a small molecule, as a promoter of mESC stemness. Danofloxacin enhances the formation of undifferentiated colonies and the generation of chimeric mice.
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Peroxisome-Dependent and -independent Functions of PEX19 in Mouse Embryonic Stem Cells

[iScience] Researchers reported an unexpected role of PEX19, a chaperone and receptor for peroxisomal membrane proteins, in regulating cell cycle and cell fates of mESCs through a peroxisome-independent mechanism.

Directing GABAergic Neuronal Identity from Human iPSCs through Developmental Patterning

[Stem Cell Reports] Scientists showed that the chromatin state of the starting population constrains the neuronal identities that ASCL1 and DLX2 can specify: patterned progenitors give rise to GABAergic neurons with cortical and ganglionic eminence-associated molecular signatures, whereas naive PSCs yield neurons with mixed regional identities, including hypothalamic and thalamic signatures.

Fate Therapeutics Announces Receipt of California Institute for Regenerative Medicine (CIRM) CLIN2 Grant to Advance RECLAIM-LN

[Fate Therapeutics, Inc.] Fate Therapeutics, Inc. announced that the California Institute for Regenerative Medicine (CIRM) has awarded the Company a $15.0 million grant, through its CLIN2 program, to support the clinical development of RECLAIM-LN, the Company's Phase II, potentially registrational trial of FT819 off-the-shelf CAR T cell in patients with refractory moderate-to-severe Systemic Lupus Erythematosus (SLE) with Lupus Nephritis (LN).
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