Emily Salmini

[Nature] Scientists show that newborn babies with E. coli sepsis have selectively reduced vertically transferred natural antibodies that recognize E. coli sepsis, mechanistically explaining their susceptibility to infection.

[Nature Reviews Genetics] Advances in targeted delivery — using viral vectors, mRNA-loaded nanoparticles and virus-like particles — are expanding the toolkit for direct programming of cells within the body.

[Blood Advances] Scientists evaluated human-specific CCR4-directed CARTs previously developed for T cell malignancies and determined whether these CARTs could deplete human Tregs ex vivo and in vivo.

[Journal for Immunotherapy of Cancer] By repurposing osalmid to restore MICA/B surface presentation, researchers provided a clinically translatable strategy that specifically potentiates NKG2D CAR-T cell efficacy in multiple myeloma and could potentially enhance the efficacy of CAR-T across diverse antigens.

[Signal Transduction and Targeted Therapy] Researchers developed a combinatorial strategy integrating irreversible electroporation, a clinically approved nonthermal ablation modality capable of reshaping the TME, with glypican-3-targeted CAR-NK cells.

[Science Immunology] In murine models of lung cancer, CAR T cells down-regulated T cell factor 1, became exhausted, and were not enhanced by PD-L1 blockade.