Emily Salmini

[Cancer Research] Scientists identified upregulation of the transcriptional corepressor DRAP1 in TNBC, which was closely associated with poor recurrence-free survival in TNBC patients.

[Endocrine] The authors review the current advances and challenges faced by stem cell differentiation into functional β-cells for diabetes treatment.

[Cell Death & Disease] Investigators reported that ubiquitin-protein ligase E3 module N-recognition 5 (UBR5) was a therapeutic target against gemcitabine (GEM) resistance. Further analysis revealed that UBR5 promoted GEM resistance in pancreatic cancer cells by enhancing O-GlcNAcylation-mediated epithelial-mesenchymal transition.

[International Journal Of Biological Macromolecules] Investigators utilized biocompatible copolymers of L-lactide and D,L-lactide to manufacture a biomaterial scaffold with a mesh-like structure via 3D printing technology, providing a material foundation for encapsulating pancreatic islet cells.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists described a group of basal forebrain (BF) neurons expressing neuronal Per-Arnt-Sim (PAS) domain 1 (Npas1), a developmental transcription factor linked to neuropsychiatric disorders.

[Acta Neuropathologica] Leveraging advanced induced pluripotent stem cell technology, investigators cultivated multiple astrocyte lines to further investigate the Japanese variant of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC).