Emily Salmini

Hepatic Cell News

TERN-501 Monotherapy and Combination Therapy with TERN-101 in Metabolic Dysfunction-Associated Steatohepatitis: The Randomized Phase IIa DUET Trial

[Nature Medicine] DUET was a 12-week, randomized, double-blind, placebo-controlled, multicenter Phase IIa study investigating the efficacy, safety, and pharmacodynamics and pharmacokinetics of once-daily TERN-501 as monotherapy or combined with TERN-101, in patients with presumed metabolic dysfunction-associated steatohepatitis.

Hepatic Cell News

Reproductive State Controls Transcription in the Murine Liver, with Implications for Breast Cancer Liver Metastasis

[Proceedings of The National Academy of Sciences of The United States of America] Investigators employed transcriptomic profilingg and identified elevated hepatocyte proliferation and anabolic metabolism gene signatures during lactation, consistent with the liver being a major producer of substrates needed for milk production.

Hepatic Cell News

Immunopathogenic Mechanisms and Immunoregulatory Therapies in MASLD

[Cellular & Molecular Immunology] Scientists provide an in-depth discussion of current data related to the immunological mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) and summarize the effects of current and experimental therapies on immunoregulation in MASLD.

Hepatic Cell News

Endoplasmic Reticulum Stress Sensor Protein PERK in Hepatic Stellate Cells Promotes the Progression of Hepatocellular Carcinoma via P38δ MAPK/IL-1β Axis

[Scientific Reports] Researchers clarified the process of IL-1β production via PERK in hepatic stellate cells and explored the mechanism underlying MASH-related HCC progression.

Hepatic Cell News

Cholangiocytes Contribute to Hepatocyte Regeneration after Partial Liver Injury during Growth Spurt in Zebrafish

[Nature Communications] Researchers designed two partial liver injury models in zebrafish, which were investigated during growth spurts: 1) partial ablation, killing half the hepatocytes; and 2) partial hepatectomy, removing half a liver lobe. In both injuries, de novo hepatocytes emerg alongside existing ones.

Extracellular Matrix News

Wilms’ Tumor 1 Impairs Apoptotic Clearance of Fibroblasts in Distal Fibrotic Lung Lesions

[Journal of Clinical Investigation] Researchers investigated the heterogeneity of WT1-expressing mesenchymal cells using single-nucleus RNA sequencing of distal lung tissues from idiopathic pulmonary fibrosis patients (IPF) and control donors. WT1 is selectively upregulated in a subset of IPF fibroblasts that co-express several pro-survival and ECM genes.

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HepaRegeniX Doses First Patient in Phase Ib Trial with Small Molecule Inhibitor HRX-215 to Promote Liver Regeneration

[HepaRegeniX (GlobeNewswire)] HepaRegeniX announced that the first patient has been dosed in their Phase Ib clinical trial of its lead candidate HRX-215. The trial is evaluating the safety and efficacy of HRX-215, an orally available small-molecule inhibitor of MKK4, in patients undergoing partial liver resection due to liver metastases deriving from colorectal cancer.

US FDA Approves Expanded Indication for AbbVie’s MAVYRET® (Glecaprevir/Pibrentasvir) as First and Only Treatment for People with Acute Hepatitis C Virus

[AbbVie ] AbbVie announced that the US FDA approved a label expansion for MAVYRET^®, an oral pangenotypic direct acting antiviral therapy. It is now approved for the treatment of adults and pediatric patients three years and older with acute or chronic hepatitis C virus infection without cirrhosis or with compensated cirrhosis.

Small Molecule- and Cell Contact-Inducible Systems for Controlling Expression and Differentiation in Mouse Embryonic Stem Cells

[Development] Researchers presented an approach for rapid engineering of multiple inducible systems into mESCs. Small molecule- and cell contact-inducible systems work reliably and efficiently for controlling expression of arbitrary genetic payloads.

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Emily Salmini

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