Emily Salmini

Extracellular Matrix News

TYBR Health Announces FDA 510(k) Clearance for B3 GEL™ System, a Flowable Bio-Gel to Protect Healing Tissue and Preserve Function

[TYBR Health (BioSpace)] TYBR Health announced US FDA 510(k) clearance for the B3 GEL^™ System. B3 GEL^™ is a bioresorbable, flowable gel barrier designed to protect healing tissue planes and preserve mobility following surgeries involving tendons, ligaments, and skeletal muscle.

Extracellular Matrix News

Hybrid Hydrogel-Extracellular Matrix Scaffolds Identify Biochemical and Mechanical Signatures of Cardiac Aging

[Nature Materials] Scientists described a decellularized ECM–synthetic hydrogel hybrid scaffold that independently confers two distinct matrix properties—ligand presentation and stiffness—to cultured cells in vitro, allowing for the identification of their specific roles in cardiac aging.

Dermal Cell News

NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma

[Cancer Research] Researchers utilized patient-derived short-term cultures and multiomics approaches to identify molecular features that could inform the development of therapies for patients with neurofibromin 1 (NF1) mutant melanoma.

Hematopoiesis News

TP53-Mutant Variant Allele Frequency and Cytogenetics Determine Prognostic Groups in MDS/AML for Transplantation

[Blood Advances] The authors analyzed 240 patients with TP53-mutated myelodysplastic syndrome (MDS) or AML who underwent HSC transplantation.

Mesenchymal Cell News

Synergistic Potential of Bone Marrow Mesenchymal Stem Cells and mir181-A Combinational Therapy against Multiple Sclerosis

[Stem Cell Research & Therapy] Researchers proposed a synergistic therapy approach that combines the penetrative targeting capability of bone marrow MSCs (BMSCs) with the immuno-modulatory effects of miR181-a by overexpressing miR181-a to BMSCs through lentivirus packaging system.

Hepatic Cell News

The Hepatocyte Traffic Network in the Human Hepatitis a Virus Biological Cycle from an Evolutionary Perspective

[Communications Biology] Scientists proposed that hepatocytes cloaked in exosomes biogenesis may follow not only an endosomal sorting complex required for transport-mediated pathway but also the syndecan-syntenin-ALIX pathway.

1 234...479 Page 3 of 479

HepaRegeniX Doses First Patient in Phase Ib Trial with Small Molecule Inhibitor HRX-215 to Promote Liver Regeneration

[HepaRegeniX (GlobeNewswire)] HepaRegeniX announced that the first patient has been dosed in their Phase Ib clinical trial of its lead candidate HRX-215. The trial is evaluating the safety and efficacy of HRX-215, an orally available small-molecule inhibitor of MKK4, in patients undergoing partial liver resection due to liver metastases deriving from colorectal cancer.

US FDA Approves Expanded Indication for AbbVie’s MAVYRET® (Glecaprevir/Pibrentasvir) as First and Only Treatment for People with Acute Hepatitis C Virus

[AbbVie ] AbbVie announced that the US FDA approved a label expansion for MAVYRET^®, an oral pangenotypic direct acting antiviral therapy. It is now approved for the treatment of adults and pediatric patients three years and older with acute or chronic hepatitis C virus infection without cirrhosis or with compensated cirrhosis.

Small Molecule- and Cell Contact-Inducible Systems for Controlling Expression and Differentiation in Mouse Embryonic Stem Cells

[Development] Researchers presented an approach for rapid engineering of multiple inducible systems into mESCs. Small molecule- and cell contact-inducible systems work reliably and efficiently for controlling expression of arbitrary genetic payloads.

All Articles by Author:

Emily Salmini

Popular