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Pulmonary Cell NewsAll Articles by Author:
Emily Salmini
Neural Cell News
Modeling of Brain Tumors Using In Vitro, In Vivo, and Microfluidic Models: A Review of the Current Developments
[Heliyon] The authors discuss some of the most important in vitro, in vivo, and microfluidic brain tumor models that aim to address challenges, including difficulty in emulating the complexity of the brain and the surrounding microenvironment.
Neural Cell News
The Vascular Contribution of Apolipoprotein E to Alzheimer’s Disease
[Brain] The authors examine the evidence elucidating the cerebrovascular impact of both central and peripheral apolipoprotein E on the pathogenesis of Alzheimer’s disease.
Neural Cell News
The Role of Cellular Senescence in Neurodegenerative Diseases
[Archives Of Toxicology] Scientists elucidate the mechanism of cellular senescence in neurodegenerative disease pathogenesis, suggesting strategies to eliminate or restore senescent cells to a normal phenotype for treating such diseases.
Dermal Cell News
A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat Following BRAF and MEK Inhibitors in BRAFV600 mutated Melanoma
[Clinical Cancer Research] Scientists assessed the anti-tumor activity of sequential treatment with vorinostat following BRAF and MEK inhibitors (BRAFi/MEKi) in patients with BRAFV600 melanoma who progressed after initial response to BRAFi/MEKi.
Dermal Cell News
H2A.Z Chaperones Converge on E2F Target Genes for Melanoma Cell Proliferation
[Genes & Development] Researchers showed that individual subunit depletion of SRCAP, P400, and VPS72 resulted in not only the loss of H2A.Z deposition into chromatin but also a reduction of H4 acetylation in melanoma cells.
Mammary Cell News
Phosphoglycerate Mutase 1 Promotes Breast Cancer Progression through Inducing Immunosuppressive M2 Macrophages
[Cancer Gene Therapy] Scientists reported that phosphoglycerate mutase 1 suppression in breast cancer cells led to a decrease in M2 polarization, migration, and interleukin-10 production of macrophages.
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Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity
[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.
Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity
[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.
Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer
[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.
