Emily Salmini

Muscle Cell News

A Putative Structural Transition Underlies Reliable Formation of Skeletal Muscle

[Current Biology] Scientists investigated how cells shape and pack in 3D within a dense tissue with multiple cell types and spatiotemporally varying boundary constraints. They focused on the developing skeletal muscle in zebrafish.

Muscle Cell News

Clusterin, through Exercise-Mediated Liver-Heart Crosstalk, Promotes Heart Regeneration after Myocardial Infarction

[Cell Reports] Researchers demonstrated that exercise-induced exerkine clusterin mediates the pro-regenerative effects of running plasma on cardiac repair and cardiomyocyte proliferation following myocardial infarction.

Muscle Cell News

CCN1-Mediated Stress Signaling Underlies Intrinsic Cardiomyocyte Dysfunction in Spinal Muscular Atrophy

[Cell Reports] Using patient-specific iPSC-derived cardiomyocytes and engineered heart tissues, the authors identified reduced survival motor neuron expression, mitochondrial respiratory defects, and impaired contractility in spinal muscular atrophy.

Muscle Cell News

Developmental Restriction of the Jaw Skeletal Muscle Cardiogenic Potential

[Communications Biology] The authors evaluated the cardiogenic potential of satellite cells and mesenchymal progenitor cells from the masticatory muscle by reproducing, optimizing and diversifying previously described protocols.

Muscle Cell News

Challenges and Innovations in Cardiac AAV Gene Delivery as a Platform for Cardiac Regeneration

[npj Biomedical Innovations] The authors address the role of delivery in overcoming challenges in cardiac adeno-associated viral therapies. Emphasis is placed on biomaterial-based delivery approaches to improve therapeutic outcomes.

Muscle Cell News

Population-Scale Single-Nucleus Multi-Omic Profiling of Skeletal Muscle Reveals Extensive Context-Specific Genetic Regulation

[Nature Genetics] Investigators used genetic multiplexing to generate population-scale single-nucleus chromatin accessibility and transcriptome maps across 287 frozen human skeletal muscle biopsies. The results of this study illuminate the genetic regulatory architecture of human skeletal muscle.

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FibroBiologics Announces Grant of European Patent for Fibroblast Delivery of Tumor Inhibitory Agents

[FibroBiologics, Inc.] FibroBiologics, Inc. announced that the European Patent Office has granted European Patent No. EP 4454709, titled "Fibroblast Delivery of Tumor Inhibitory Agents. The patent covers methods of preparing fibroblasts as anti-cancer delivery compositions by modifying the cells to improve their ability to home to cancer cells.

Applied Biologics Announces Full Enrollment of BIOxHEAL™ Phase III Sentinel Safety Cohort

[Applied Biologics, LLC.] Applied Biologics, LLC. announced the completion of enrollment into the sentinel safety cohort of its Phase III randomized controlled clinical trial evaluating BIOxHEAL^™ in patients with chronic, nonhealing diabetic foot ulcers.

StimLabs® Announces Commercial Launch of DermaForm™, a Uniquely Engineered Collagen Scaffold Particulate Device

[StimLabs ] StimLabs announced the commercial launch of DermaForm, an FDA 510(k)-cleared porcine-derived particulate collagen scaffold that manages a range of acute and chronic wounds.

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Emily Salmini

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