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Emily Salmini

Targeting P2Y14R Protects against Necroptosis of Intestinal Epithelial Cells through PKA/CREB/RIPK1 Axis in Ulcerative Colitis

[Nature Communications] Based on the over-expression of P2Y14R in the intestinal epithelium of mice with experimental colitis, investigators reported that male mice lacking P2Y14R in intestinal epithelial cells exhibited less intestinal injury induced by dextran sulfate sodium.

Identification of EGR4 as a Prospective Target for Inhibiting Tumor Cell Proliferation and a Novel Biomarker in Colorectal Cancer

[Cancer Gene Therapy] The authors assessed the prognosis of colorectal cancer (CRC) based on early growth response 4 (EGR4) using the Kaplan-Meier plotter tool and tissue microarray.

Isoform Alterations in the Ubiquitination Machinery Impacting Gastrointestinal Malignancies

[Cell Death & Disease] The authors highlight reported examples of direct, protein-coded isoform variation of ubiquitination enzymes influencing cancer development and progression in gastrointestinal malignancies.

Vitamin A Resolves Lineage Plasticity to Orchestrate Stem Cell Lineage Choices

[Science] Investigators discovered that without resolving lineage plasticity, skin stem cells could not effectively generate each lineage in vitro nor regrow hair and repair wounded epidermis in vivo.

Aryl Hydrocarbon Receptor Suppresses STING-Mediated Type I IFN Expression in Triple-Negative Breast Cancer

[Scientific Reports] Using TNBC systems, investigators discovered the aryl hydrocarbon receptor suppressed type I interferon (IFN-I) expression via inhibition of STImulator of Interferon Genes (STING), a key mediator of interferon production.

USask Breast Cancer Research Targets Post-Treatment Function, Rehabilitation

[University of Saskatchewan College of Medicine] Dr. Angelica Lang's research project received $348,076 over four years from the Canadian Institutes of Health Research Project Grant program. Lang’s research explores relationships between types of surgeries and subsequent movement pattern alterations, as well as their implications for post-surgery rehabilitation.

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Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.