Jamie Kang

Extracellular Matrix News

Mechanical Properties, Collagen and Glycosaminoglycan Content of Equine Superficial Digital Flexor Tendons Are Not Affected by Training

[Journal Of Anatomy] Scientists investigated whether different training histories of horses would influence the synthesis of collagen and other matrix proteins and alter the mechanical properties of tendon.

Extracellular Matrix News

Synergistic Effects of Matrix Biophysical Properties on Gastric Cancer Cell Behavior via Integrin-Mediated Cell-ECM Interactions

[Small] By combining collagen I and alginate, researchers designed an in vitro biomimetic hydrogel platform to independently modulate matrix stiffness and structure across a physiological stiffness spectrum while preserving consistent collagen concentration and fiber topography.

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ARID1B Controls Transcriptional Programs of Axon Projection in an Organoid Model of the Human Corpus Callosum

[Cell Stem Cell] Researchers found that neurons expressing SATB2, a determinant of callosal projection neuron (CPN) identity, show impaired maturation in ARID1B+/− neural organoids.

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Cerebral Organoids Display Dynamic Clonal Growth and Tunable Tissue Replenishment

[Nature Cell Biology] Investigators implemented whole-tissue lineage tracing by genomic DNA barcoding in 3D human cerebral organoids, to show that individual stem cell clones produced progeny on a vastly variable scale.

Immune Regulation News

The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance

[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, investigators identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.

Immune Regulation News

Thymocyte Migration and Emigration

[Immunology Letters] Investigators review the contribution of the key factors mentioned above for the localization, migration and emigration of thymocytes.

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circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

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Jamie Kang

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