Jamie Kang

[Molecular Cancer] Through novel observational methods focused on human living and fixed tissue, scientists profiled the spatial and molecular features of microsatellite stable colorectal liver metastasis and the surrounding liver microenvironment.

[Nature Immunology] Researchers presented a comprehensive analysis of T cells from human lungs. They mapped the pathogen specificity of more than 87,000 lung T cells across 40 individuals, the majority of whom harbored memory T cells specific to multiple pathogens.

[Nature Communications] Scientists showed, in a nested case-control study within a low-risk, population-based pregnancy cohort, that an abnormal immune adaptation in mothers’ blood precedes spontaneous preterm births (sPTB) by weeks to months and discriminates sPTB cases from term controls.

[Cell Reports] Researchers demonstrated that human GBP4 promotes the containment of intracellular Mtb by enhancing autophagy. We identify progranulin (GRN) as a major GBP4-interacting protein and a key regulator of autophagy in Mtb-infected human macrophages.

[Nature Reviews Cancer] The authors examine the molecular mechanisms by which DNA damage response (DDR) defects potentiate immunotherapy, including recent advances in DDR-targeted combination strategies.

[Autoimmunity Reviews] Scientists summarize how apoptosis, necroptosis, pyroptosis, and ferroptosis operate as an interlocking network in autoimmune microenvironments, frequently co-existing as context-dependent mixed-death states driven by shared triggers such as cytokines, PRR ligands, and oxidative stress.