Jamie Kang

[Metabolism Clinical and Experimental] Researchers studied 63 individuals undergoing partial pancreatectomy who underwent preoperative OGTT with model-based assessment of β cell function and provided pancreatic tissue for ex vivo islet isolation and glucose stimulation.

[Cancer Letters] Scientists established Foxa1-orchestrated enhancer reprogramming as a fundamental mechanism of gemcitabine resistance and unveil a promising epigenetic therapy to restore treatment efficacy in PDAC.

[Diabetes] Scientists demonstrated that replication introduces a window of genomic vulnerability in both α- and β-cells during neonatal growth, with α-cells exhibiting higher replication rates and DNA damage.

[Molecular Cell] Investigators demonstrated that histone deacetylase 5 (HDAC5) mediates the deacetylation of forkhead box A1 (FOXA1) at lysine residue 270, leading to repression of FOXA1’s global chromatin occupancy.

[Cancer Immunology Research] The authors establish cancer-associated fibroblast-stratified ductal spatial architecture as a fundamental determinant of immune exclusion in PDAC.

[Cancer Letters] Using a mCherry-tagged Gstt1 reporter system in metastatic murine PDAC cells, investigators enriched for Gstt1^High cells and observed increased tumor sphere formation, accompanied by upregulation of stemness-associated genes including PROM1 (CD133) and activation of Wnt and FGF signaling pathways.