Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Patient-Derived Tumor Organoids Highlight the Potential of Precision Medicine in Managing Pancreatic Ductal Adenocarcinoma
[International Journal of Cancer] Scientists employed patient-derived three dimensional tumor organoid technology to assess drug sensitivities of patient-derived tumor organoids to clinically relevant drugs and combinations, evaluated culture success rates, and correlated in vitro data with clinicopathological and follow-up information.
An Organoid Library Unveils Subtype-Specific IGF-1 Dependency via a YAP-AP1 Axis in Human Small Cell Lung Cancer
[Nature Cancer] The authors established 40 patient-derived small cell lung cancer organoid lines with predominant TP53 and RB1 alterations and rare targetable genetic lesions.
Dasatinib Demonstrates Efficacy in Organoid Derived Paclitaxel-Resistant Trp53/Cdh1-Deficient Mouse Gastric Adenocarcinoma with Peritoneal Metastasis
[Cell Regeneration] Scientists derived a mouse gastric cancer (GC) cell line, called MTC, from subcutaneously transplanted mouse Trp53−/−Cdh1−/− GC organoids.
Insights into Modeling Inflammatory Bowel Disease from Stem Cell Derived Intestinal Organoids
[Stem Cell Reviews and Reports] The authors briefly consolidate current knowledge on inflammatory bowel disease pathogenesis and treatments and emphasize the pivotal potential of human intestinal organoids as a robust platform for mechanistic studies and treatment exploration.
The Potential of Brain Organoids in Addressing the Heterogeneity of Synucleinopathies
[Cellular and Molecular Life Sciences] The authors summarize current advances in investigating the mechanisms of synucleinopathies using brain organoids and discuss the scope of this platform to define mechanisms underlining the selective vulnerability of cell types and brain regions in synucleinopathies.
Transcriptional Landscape and Chromatin Accessibility Reveal Key Regulators for Liver Regenerative Initiation and Organoid Formation
[Cell Reports] Comprehensive integration of RNA sequencing and ATAC sequencing revealed that ATF3 representing “Initiation_on” TF and ONECUT2 representing “Initiation_off” TF transiently modulate the occupancy of target promoters to license liver cells for regeneration.
ErbB2/HER2-Targeted CAR-NK Cells Eliminate Breast Cancer Cells in an Organoid Model That Recapitulates Tumor Progression
[Molecular Therapy] To evaluate activity of NK-92/5.28.z cells against ErbB2-positive breast cancer, researchers developed an organoid model derived from CKP mice that allowed conditional activation of oncogenic driver mutations.
hESCs-derived Organoids Achieve Liver Zonation Features through LSEC Modulation
[Advanced Science] The authors explored the feasibility of achieving zonated organoid by co-culturing hESCs derived hepatocytes with hESCs derived liver sinusoidal endothelial cells (LSECs) exhibiting characteristics of either the liver lobule's pericentral or periportal regions.
Tumor Organoid-Immune Co-Culture Models: Exploring a New Perspective of Tumor Immunity
[Cell Death Discovery] Investigators discuss the progress achieved in co-culturing tumor organoids with immune cells.
Human iPS Cell-Derived Respiratory Organoids As a Model for Respiratory Syncytial Virus Infection
[Life Science Alliance] The authors evaluated hiPSC-derived respiratory organoids, which contained respiratory epithelial cells, immune cells, fibroblasts, and vascular endothelial cells, for their potential to model respiratory syncytial virus infection and support pharmaceutical research.
Engineering Neuronal Networks in Granular Microgels to Innervate Bioprinted Cancer Organoids On-a-Chip
[Lab On A Chip] Researchers presented a versatile organ-on-a-chip platform designed to innervate organoids across diverse tissue types.
Impact of Enzymatic Isolation on the Propagation Efficiency of Patient-Derived Colorectal Cancer Organoids
[Scientific Reports] Researchers evaluated the role of enzymatic isolation in generating patient-derived organoids from colorectal cancer tissues by comparing four enzymatic methods: TrypLE, Trypsin–EDTA, Collagenase, and Hyaluronidase.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
