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Poria Cocos-Derived Exosome-Like Nanoparticles Ameliorate Lymphedema by Reprogramming Fibroblast Metabolism via Enhanced TCA Cycle Flux

February 25, 2026

[Journal of Nanobiotechnology] Scientists demonstrated that plant-derived exosome-like nanoparticles represent a novel and effective nanotherapeutic strategy for lymphedema by orchestrating metabolic reprogramming and inhibiting fibrosis.

Hydrostatic Pressure Regulates Glutamine Metabolism to Promote Bladder Fibroblast Activation via the Piezo1/YAP1/GLS1 Axis

February 25, 2026

[Journal of Translational Medicine] Investigators identified a Piezo1/Yes-associated protein 1 (YAP1)/glutaminase 1 (GLS1) axis linking mechanical stress to metabolic reprogramming and fibroblast activation in bladder outlet obstruction, which may serve as a therapeutic target to prevent fibrosis and preserve bladder function.

A FGFR3 Decoy Receptor Attenuates Lung Fibroblast-to-Myofibroblast Transition and Pulmonary Fibrosis

February 25, 2026

[American Journal of Respiratory Cell and Molecular Biology] Researchers showed that fibroblast growth factor 2 stimulated proliferation and expression of various fibrotic markers in human pulmonary fibroblasts from healthy donors and idiopathic pulmonary fibrosis patients.

Cell Adhesion Molecule 1 Is Upregulated in Connective Tissue Mast Cells and Potentially Contributes in IgE-Mediated Degranulation

February 25, 2026

[Scientific Reports] Researchers investigated cell adhesion molecule 1 (CADM1) function in connective tissue mast cells (CTMCs) using a monoclonal antibody against the extracellular domain of CADM1, termed 3E1.

Androgen Dysregulates the Follicular Extracellular Matrix and Increases Pro-Fibrotic Gene Expression in the Mouse Ovary

February 25, 2026

[Scientific Reports] PCOS is characterized by hyperandrogenism and, here, scientists investigated the impact of androgens on fibrosis, cell-ECM interactions and mechanosensing. They reported an altered network of gene expression related to the genesis of fibrosis.

Choline Attenuates Bilirubin Induced Effects on Tyrosine Phosphorylation and Distribution in Lipid Rafts of L1 Cell Adhesion Molecule In Vivo

February 25, 2026

[Pediatric Research] Choline supplementation ameliorates the biochemical effects of bilirubin on L1 cell adhesion molecule in vivo on choline-deficient hyperbilirubinemic jj Gunn rat pups.

Fibroblasts As Regulators of Lung Immunity, Repair, and Fibrosis

February 25, 2026

[Nature Reviews Immunology] The authors show how loss of stromal regulation through chronic inflammation, immune dysfunction, altered tissue biomechanics and metabolic stress can tip the balance from successful tissue repair to progressive fibrosis.

PureTech Announces Orphan Drug Designations Granted by the US Food and Drug Administration and European Commission for Deupirfenidone (LYT-100) in Idiopathic Pulmonary Fibrosis

February 25, 2026

[PureTech Health (Businesswire)] PureTech Health announced that the US FDA and European Commission have granted Orphan Drug Designation to deupirfenidone for the treatment of idiopathic pulmonary fibrosis, a rare, progressive, and fatal lung disease.

Sensory Neurons Drive Immune Exclusion by Stimulating a Dense Extracellular Matrix in the Breast Cancer Tumor Microenvironment

February 12, 2026

[Cell] The authors deciphered that sensory neurons, the dominant neuron type in the triple negative breast cancer ecosystem, drive the immune-excluded tumor microenvironment by stimulating a dense extracellular matrix.

Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis

February 12, 2026

[Advanced Materials] Scientists hypothesized that ECM softening in periodontal disease contributes to inflammation by dysregulating gingival fibroblasts.

Extracellular Matrix Mediates Circulating Tumor Cell Clustering in Triple-Negative Breast Cancer Metastasis

February 12, 2026

[Nature Communications] Researchers showed that the ECM component hyaluronan mediates adherens junction-independent circulating tumor cell clustering in triple-negative breast cancers.

FOXI3 Establishes the Ectodermal Niche in Pharyngeal Arches for Cranial Neural Crest Cells and Their Lineages

February 12, 2026

[Bone Research] Deletion of Foxi3 in the mouse cranial neural crest cells (CNCCs) did not disrupt mandible and auricular development, further confirming that FOXI3 does not directly regulate CNCCs.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.