Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
B Cells Modulate Lung Antiviral Inflammatory Responses via the Neurotransmitter Acetylcholine
[Nature Immunology] The authors reported that B cells are the most prevalent acetylcholine-producing leukocyte population in the respiratory tract demonstrated with choline acetyltransferase-green fluorescent protein reporter mice, both before and after infection with influenza A virus.
Variant Mutation G215C in SARS-CoV-2 Nucleocapsid Enhances Viral Infection via Altered Genomic Encapsidation
[PLOS Biology] Scientists identified a mutation (G215C), characteristic of the Delta variant, that introduces a novel cysteine into this linker domain, which results in the formation of a more stable N-N dimer.
M. tuberculosis Surface Sulfoglycolipid SL-1 Activates the Mechanosensitive Channel TRPV4 to Enhance Lysosomal Biogenesis and Exocytosis in Macrophages
[Molecular Biology of the Cell] Researchers showed that sulfolipid-1 (SL-1) induces calcium influx into macrophages and identified the mechanosensitive calcium channel TRPV4 as a crucial upstream mediator of SL-1–induced lysosomal remodeling.
Genomic Analysis of Progenitors in Viral Infection Implicates Glucocorticoids As Suppressors of Plasmacytoid Dendritic Cell Generation
[Proceedings of The National Academy of Sciences of The United States of America] Investigators characterized the transcriptional and epigenetic landscapes of dendritic cell progenitors after infection.
A Distinctive IGHV3-66 SARS-CoV-2 Neutralizing Antibody Elicited by Primary Infection with an Omicron Variant
[Structure] Scientists reported an IGHV3-66-encoding monoclonal neutralizing antibody (nAb), ConBA-998, that was elicited by primary infection with BA.1. ConBA-998 is an Omicron-dependent nAb with high binding affinity that triggers the shedding of the S1 subunit from the spike protein.
Mycobacterium marinum As a Model for Understanding Principles of Mycobacterial Pathogenesis
[Journal of Bacteriology] Scientists discuss the discovery of M. marinum as an occasional human pathogen, the shared aspects of pathogenesis with M. tuberculosis, and how M. marinum has been exploited as a model to define the molecular mechanisms of mycobacterial pathogenesis across several phases of infection.
Lucas Bio Partners with Samsung Medical Center to Develop Pediatric Cystitis Treatment
[CHOSUNBIZ] Lucas Bio will collaborate with Samsung Medical Center on the development of a treatment for pediatric viral cystitis. It was selected for the Ministry of Health and Welfare's 'Research and Development (R&D) for Overcoming Pediatric Diseases - Support for Pediatric Clinical Trials' national project.
ATG9 Inhibits Rickettsia Binding to the Host Cell Surface by Blocking the rOmpB-XRCC6/KU70 Interaction
[Autophagy] The authors reported that autophagy related 9 (ATG9) played a previously unrecognized role in inhibiting Rickettsia binding to the host cell surface.
An Intranasally Administered IgM Protects against Antigenically Distinct Subtypes of Influenza A Viruses
[Nature Communications] Investigators constructed 18 IgM antibodies from known broadly neutralizing IgGs targeting different influenza A virus (IAV) hemagglutinin epitopes and evaluated their breadth and potency of neutralization against distinct H1N1 and H3N2 IAVs.
CD8α Marks a Mycobacterium Tuberculosis-Reactive Human NK Cell Population with High Activation Potential
[Scientific Reports] To identify Mycobacterium tuberculosis (Mtb)-responsive NK cell populations, investigators analyzed the peripheral blood of healthy household contacts of active tuberculosis cases and source community donors in an endemic region of Port-au-Prince, Haiti by flow cytometry.
Identification of Immune Phenotypes and Diagnostic Biomarkers in Active and Latent Tuberculosis Infections
[Scientific Reports] Scientists identified potential immune response mechanisms by integrating gene expression analysis with immune cell distribution profiling to characterize the immune phenotypes of active tuberculosis and latent tuberculosis infection.
The Bat Influenza a Virus Subtype H18N11 Induces Nanoscale MHCII Clustering upon Host Cell Attachment
[Nature Communications] Using photoactivated localization microscopy on fixed and live cells, scientists demonstrated that bat influenza A virus particles attached to pre-existing MHCII clusters and induced a further increase in cluster size upon binding.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
